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Cunningham virus</title> <meta name="description" content="Search results for: John Cunningham virus"> <meta name="keywords" content="John Cunningham virus"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="John Cunningham virus"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1334</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: John Cunningham virus</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1334</span> John Cunningham Virus Interaction with Multiple Sclerosis Disease Progression</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sina%20Mahdavi">Sina Mahdavi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background and Objective: Multiple sclerosis (MS) is the most common inflammatory autoimmune disease of the central nervous system (CNS) that affects the myelination process in the CNS. Complex interactions of various "environmental or infectious" factors may act as triggers in autoimmunity and disease progression. The association between viral infections, especially the John Cunningham virus (JCV) and MS is one potential cause that is not well understood. This study aims to summarize the available data on JCV infection in MS disease progression. Materials and Methods: For this study, the keywords "Multiple sclerosis", " John Cunningham virus ", and "central nervous system" in the databases PubMed, Google Scholar, Sid, and MagIran between 2019 and 2022 were searched, and 12 articles were chosen, studied, and analyzed. Results: MS patients are candidates for natalizumab therapy, which inhibits lymphocyte migration and increases the risk of progressive multifocal leukoencephalopathy (PML), a rare lytic infection of glial cells caused by JCV. Oligodendrocytes may be the target of JCV infection in the central nervous system (CNS). Conclusion: There is a high expression of JCV during the natalizumab treatment period for MS patients, suggesting that the virus may play a role in the development of MS by inducing an inflammatory state. Therefore, it is necessary to evaluate anti-JCV antibody serum as an important risk factor for the development of PML before deciding on the treatment course for these patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multiple%20sclerosis" title="multiple sclerosis">multiple sclerosis</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Cunningham%20virus" title=" John Cunningham virus"> John Cunningham virus</a>, <a href="https://publications.waset.org/abstracts/search?q=central%20nervous%20system" title=" central nervous system"> central nervous system</a>, <a href="https://publications.waset.org/abstracts/search?q=autoimmunity" title=" autoimmunity"> autoimmunity</a> </p> <a href="https://publications.waset.org/abstracts/159420/john-cunningham-virus-interaction-with-multiple-sclerosis-disease-progression" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159420.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1333</span> Diffraction-Based Immunosensor for Dengue NS1 Virus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Harriet%20Jane%20R.%20Caleja">Harriet Jane R. Caleja</a>, <a href="https://publications.waset.org/abstracts/search?q=Joel%20I.%20Ballesteros"> Joel I. Ballesteros</a>, <a href="https://publications.waset.org/abstracts/search?q=Florian%20R.%20Del%20Mundo"> Florian R. Del Mundo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The dengue fever belongs to the world’s major cause of death, especially in the tropical areas. In the Philippines, the number of dengue cases during the first half of 2015 amounted to more than 50,000. In 2012, the total number of cases of dengue infection reached 132,046 of which 701 patients died. Dengue Nonstructural 1 virus (Dengue NS1 virus) is a recently discovered biomarker for the early detection of dengue virus. It is present in the serum of the dengue virus infected patients even during the earliest stages prior to the formation of dengue virus antibodies. A biosensor for the dengue detection using NS1 virus was developed for faster and accurate diagnostic tool. Biotinylated anti-dengue virus NS1 was used as the receptor for dengue virus NS1. Using the Diffractive Optics Technology (dotTM) technique, real time binding of the NS1 virus to the biotinylated anti-NS1 antibody is observed. The dot®-Avidin sensor recognizes the biotinylated anti-NS1 and this served as the capture molecule to the analyte, NS1 virus. The increase in the signal of the diffractive intensity signifies the binding of the capture and the analyte. The LOD was found to be 3.87 ng/mL while the LOQ is 12.9 ng/mL. The developed biosensor was also found to be specific for the NS1 virus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=avidin-biotin" title="avidin-biotin">avidin-biotin</a>, <a href="https://publications.waset.org/abstracts/search?q=diffractive%20optics%20technology" title=" diffractive optics technology"> diffractive optics technology</a>, <a href="https://publications.waset.org/abstracts/search?q=immunosensor" title=" immunosensor"> immunosensor</a>, <a href="https://publications.waset.org/abstracts/search?q=NS1" title=" NS1"> NS1</a> </p> <a href="https://publications.waset.org/abstracts/38525/diffraction-based-immunosensor-for-dengue-ns1-virus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38525.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">329</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1332</span> A Psycholinguistic Analysis of John Nash’s Hallucinations as Represented in the Film “A Beautiful Mind”</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rizkia%20Shafarini">Rizkia Shafarini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The film A Beautiful Mind explores hallucination in this study. A Beautiful Mind depicts the tale of John Nash, a university student who dislikes studying in class or prefers to study alone. Throughout his life, John Nash has hallucinated, or what is known as schizophrenia, as depicted in the film A Beautiful Mind. The goal of this study was to figure out what hallucinations were, what caused them, and how John Nash managed his hallucinations. In general, this study examines the link between language and mind, or the linguistic relationship portrayed in John Nash's character's speech, as evidenced by his conduct. This study takes a psycholinguistic approach to data analysis by employing qualitative methodologies. Data sources include talks and scenes from the film A Beautiful Mind. Hearing, seeing, and feeling are the scientific results of John Nash's hallucinations in the film A Beautiful Mind. Second, dreams, aspirations, and sickness are the sources of John Nash's hallucinations. Third, John Nash's method of managing hallucinations is to see a doctor without medical or distracting assistance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=A%20Beautiful%20Mind" title="A Beautiful Mind">A Beautiful Mind</a>, <a href="https://publications.waset.org/abstracts/search?q=hallucination" title=" hallucination"> hallucination</a>, <a href="https://publications.waset.org/abstracts/search?q=psycholinguistic" title=" psycholinguistic"> psycholinguistic</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Nash" title=" John Nash"> John Nash</a> </p> <a href="https://publications.waset.org/abstracts/144856/a-psycholinguistic-analysis-of-john-nashs-hallucinations-as-represented-in-the-film-a-beautiful-mind" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/144856.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">168</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1331</span> A Comparative Study of Virus Detection Techniques</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sulaiman%20Al%20amro">Sulaiman Al amro</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Alkhalifah"> Ali Alkhalifah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The growing number of computer viruses and the detection of zero day malware have been the concern for security researchers for a large period of time. Existing antivirus products (AVs) rely on detecting virus signatures which do not provide a full solution to the problems associated with these viruses. The use of logic formulae to model the behaviour of viruses is one of the most encouraging recent developments in virus research, which provides alternatives to classic virus detection methods. In this paper, we proposed a comparative study about different virus detection techniques. This paper provides the advantages and drawbacks of different detection techniques. Different techniques will be used in this paper to provide a discussion about what technique is more effective to detect computer viruses. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=computer%20viruses" title="computer viruses">computer viruses</a>, <a href="https://publications.waset.org/abstracts/search?q=virus%20detection" title=" virus detection"> virus detection</a>, <a href="https://publications.waset.org/abstracts/search?q=signature-based" title=" signature-based"> signature-based</a>, <a href="https://publications.waset.org/abstracts/search?q=behaviour-based" title=" behaviour-based"> behaviour-based</a>, <a href="https://publications.waset.org/abstracts/search?q=heuristic-based" title=" heuristic-based "> heuristic-based </a> </p> <a href="https://publications.waset.org/abstracts/28688/a-comparative-study-of-virus-detection-techniques" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28688.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">484</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1330</span> Zika Virus NS5 Protein Potential Inhibitors: An Enhanced in silico Approach in Drug Discovery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pritika%20Ramharack">Pritika Ramharack</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20E.%20S.%20Soliman"> Mahmoud E. S. Soliman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The re-emerging Zika virus is an arthropod-borne virus that has been described to have explosive potential as a worldwide pandemic. The initial transmission of the virus was through a mosquito vector, however, evolving modes of transmission has allowed the spread of the disease over continents. The virus already been linked to irreversible chronic central nervous system (CNS) conditions. The concerns of the scientific and clinical community are the consequences of Zika viral mutations, thus suggesting the urgent need for viral inhibitors. There have been large strides in vaccine development against the virus but there are still no FDA-approved drugs available. Rapid rational drug design and discovery research is fundamental in the production of potent inhibitors against the virus that will not just mask the virus, but destroy it completely. In silico drug design allows for this prompt screening of potential leads, thus decreasing the consumption of precious time and resources. This study demonstrates an optimized and proven screening technique in the discovery of two potential small molecule inhibitors of Zika virus Methyltransferase and RNA-dependent RNA polymerase. This in silico “per-residue energy decomposition pharmacophore” virtual screening approach will be critical in aiding scientists in the discovery of not only effective inhibitors of Zika viral targets, but also a wide range of anti-viral agents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=NS5%20protein%20inhibitors" title="NS5 protein inhibitors">NS5 protein inhibitors</a>, <a href="https://publications.waset.org/abstracts/search?q=per-residue%20decomposition" title=" per-residue decomposition"> per-residue decomposition</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacophore%20model" title=" pharmacophore model"> pharmacophore model</a>, <a href="https://publications.waset.org/abstracts/search?q=virtual%20screening" title=" virtual screening"> virtual screening</a>, <a href="https://publications.waset.org/abstracts/search?q=Zika%20virus" title=" Zika virus"> Zika virus</a> </p> <a href="https://publications.waset.org/abstracts/59456/zika-virus-ns5-protein-potential-inhibitors-an-enhanced-in-silico-approach-in-drug-discovery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59456.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">226</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1329</span> Biopsy Proven Polyoma (BK) Virus in Saudi Kidney Recipients – Prevalence, Clinicopathological Features and Clinico-Pathological Correlations </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sarah%20Hamdan%20Al-Jahdali">Sarah Hamdan Al-Jahdali</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaled%20Alsaad"> Khaled Alsaad</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20Al-Sayyari"> Abdullah Al-Sayyari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: To study the prevalence, clinicopathological features, risk factors and outcome of biopsy proven polyoma (BK) virus infection among Saudi kidney transplant recipients and compare them to negative BK virus group. Methods: We retrospectively reviewed the charts of all the patients with biopsy-proven polyoma (BK) virus infection in King Abdulaziz Medical City in Riyadh between 2005 and 2011. The details of clinical presentation, the indication for kidney biopsy, the laboratory findings at presentation, the natural history of the disease, thepathological findings, the prognosis as well as the response to therapy were all recorded. Results: Kidney biopsy was performed in 37 cases of unexplained graft dysfunction. BK virus was found in 10 (27%). Out of those 10, 3 (30%) ended with graft failure. BK virus occurred in all patients who received ATG induction therapy 100% versus 59.3% in the non BK virus patients (p=0.06). Furthermore, the risk of BK virus was much less in those who received acyclovir as an anti-viral prophylaxis as compared to those who did not receive it (p=0.01). Also, patients with BK virus weighed much less (mean 46.7±20.6 Kgs) than those without BK virus at time of transplantation (mean 64.3±12.1). Graft survival was better among deceased donor kidneys compared to living ones (P=0.016) and with older age (P=0.005). Conclusion: Our findings suggest the involvement of ATG induction therapy, the lack of antiviral prophylaxis therapy and lower weight at transplant as significant risk factors for the development of BK virus infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=BKVAN" title="BKVAN">BKVAN</a>, <a href="https://publications.waset.org/abstracts/search?q=BKV" title=" BKV"> BKV</a>, <a href="https://publications.waset.org/abstracts/search?q=kidney%20transpant" title=" kidney transpant"> kidney transpant</a>, <a href="https://publications.waset.org/abstracts/search?q=Saudi%20Arabia" title=" Saudi Arabia"> Saudi Arabia</a> </p> <a href="https://publications.waset.org/abstracts/30336/biopsy-proven-polyoma-bk-virus-in-saudi-kidney-recipients-prevalence-clinicopathological-features-and-clinico-pathological-correlations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30336.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">283</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1328</span> Household Low Temperature MS2 (ATCC15597-B1) Virus Inactivation Using a Hot Bubble Column Evaporator</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adrian%20Garrido%20Sanchis">Adrian Garrido Sanchis</a>, <a href="https://publications.waset.org/abstracts/search?q=Richard%20Pashley"> Richard Pashley</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The MS2 (ATCC15597-B1) virus was used as a surrogate to estimate the inactivation rates for enteric viruses when using a hot air bubble column evaporator (HBCE) system in the treatment of household wastewater. In this study, we have combined MS2 virus surface charging properties with thermal inactivation rates, using an improved double layer plaque assay technique, in order to assess the efficiency of the HBCE process for virus removal in water. When bubbling a continuous flow of dry air, at 200°C, only heats the aqueous solution in the bubble column to about 50°C. Viruses are not inactivated by this solution temperature, as confirmed separately from water bath heating experiments. Hence, the efficiency of the HBCE process for virus removal in water appeared to be caused entirely by collisions between the hot air bubbles and the virus organisms. This new energy efficient treatment for water reuse applications can reduce the thermal energy required to only 25% (about 113.7 kJ/L) of that required for boiling (about 450 kJ/L). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MS2%20virus%20inactivation" title="MS2 virus inactivation">MS2 virus inactivation</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20reuse" title=" water reuse"> water reuse</a>, <a href="https://publications.waset.org/abstracts/search?q=hot%20bubble%20column%20evaporator" title=" hot bubble column evaporator"> hot bubble column evaporator</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20treatment" title=" water treatment"> water treatment</a> </p> <a href="https://publications.waset.org/abstracts/84622/household-low-temperature-ms2-atcc15597-b1-virus-inactivation-using-a-hot-bubble-column-evaporator" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84622.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">210</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1327</span> Survey of Potato Viral Infection Using Das-Elisa Method in Georgia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Maia%20Kukhaleishvili">Maia Kukhaleishvili</a>, <a href="https://publications.waset.org/abstracts/search?q=Ekaterine%20Bulauri"> Ekaterine Bulauri</a>, <a href="https://publications.waset.org/abstracts/search?q=Iveta%20Megrelishvili"> Iveta Megrelishvili</a>, <a href="https://publications.waset.org/abstracts/search?q=Tamar%20Shamatava"> Tamar Shamatava</a>, <a href="https://publications.waset.org/abstracts/search?q=Tamar%20Chipashvili"> Tamar Chipashvili</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Plant viruses can cause loss of yield and quality in a lot of important crops. Symptoms of pathogens are variable depending on the cultivars and virus strain. Selection of resistant potato varieties would reduce the risk of virus transmission and significant economic impact. Other way to avoid reduced harvest yields is regular potato seed production sampling and testing for viral infection. The aim of this study was to determine the occurrence and distribution of viral diseases according potato cultivars for further selection of virus-free material in Georgia. During the summer 2015- 2016, 5 potato cultivars (Sante, Laura, Jelly, Red Sonia, Anushka) at 5 different farms located in Akhalkalaki were tested for 6 different potato viruses: Potato virus A (PVA), Potato virus M (PVM), Potato virus S (PVS), Potato virus X (PVX), Potato virus Y (PVY) and potato leaf roll virus (PLRV). A serological method, Double Antibody Sandwich-Enzyme linked Immunosorbent Assay (DASELISA) was used at the laboratory to analyze the results. The result showed that PVY (21.4%) and PLRV (19.7%) virus presence in collected samples was relatively high compared to others. Researched potato cultivars except Jelly and Laura were infected by PVY with different concentrations. PLRV was found only in three potato cultivars (Sante, Jelly, Red Sonia) and PVM virus (3.12%) was characterized with low prevalence. PVX, PVA and PVS virus infection was not reported. It would be noted that 7.9% of samples were containing PVY/PLRV mix infection. Based on the results it can be concluded that PVY and PLRV infections are dominant in all research cultivars. Therefore significant yield losses are expected. Systematic, long-term control of potato viral infection, especially seed-potatoes, must be regarded as the most important factor to increase seed productivity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=virus" title="virus">virus</a>, <a href="https://publications.waset.org/abstracts/search?q=potato" title=" potato"> potato</a>, <a href="https://publications.waset.org/abstracts/search?q=infection" title=" infection"> infection</a>, <a href="https://publications.waset.org/abstracts/search?q=diseases" title=" diseases"> diseases</a> </p> <a href="https://publications.waset.org/abstracts/100087/survey-of-potato-viral-infection-using-das-elisa-method-in-georgia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100087.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">290</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1326</span> Eradication of Apple mosaic virus from Corylus avellana L. via Cryotherapy and Confirmation of Virus-Free Plants via Reverse Transcriptase Polymerase Chain Reaction</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ergun%20Kaya">Ergun Kaya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Apple mosaic virus (ApMV) is an ilarvirus causing harmful damages and product loses in many plant species. Because of xylem and phloem vessels absence, plant meristem tissues used for meristem cultures are virus-free, but sometimes only meristem cultures are not sufficient for virus elimination. Cryotherapy, a new method based on cryogenic techniques, is used for virus elimination. In this technique, 0.1-0.3mm meristems are excised from organized shoot apex of a selected in vitro donor plant and these meristems are frozen in liquid nitrogen (-196 °C) using suitable cryogenic technique. The aim of this work was to develop an efficient procedure for ApMV-free hazelnut via cryotherapy technique and confirmation of virus-free plants using Reverse Transcriptase-PCR technique. 100% virus free plantlets were obtained using droplet-vitrification method involved cold hardening in vitro cultures of hazelnut, 24 hours sucrose preculture of meristems on MS medium supplemented with 0.4M sucrose, and a 90 min PVS2 treatment in droplets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=droplet%20vitrification" title="droplet vitrification">droplet vitrification</a>, <a href="https://publications.waset.org/abstracts/search?q=hazelnut" title=" hazelnut"> hazelnut</a>, <a href="https://publications.waset.org/abstracts/search?q=liquid%20nitrogen" title=" liquid nitrogen"> liquid nitrogen</a>, <a href="https://publications.waset.org/abstracts/search?q=PVS2" title=" PVS2"> PVS2</a> </p> <a href="https://publications.waset.org/abstracts/89231/eradication-of-apple-mosaic-virus-from-corylus-avellana-l-via-cryotherapy-and-confirmation-of-virus-free-plants-via-reverse-transcriptase-polymerase-chain-reaction" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89231.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1325</span> Global Analysis of HIV Virus Models with Cell-to-Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Pourbashash">Hossein Pourbashash</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recent experimental studies have shown that HIV can be transmitted directly from cell to cell when structures called virological synapses form during interactions between T cells. In this article, we describe a new within-host model of HIV infection that incorporates two mechanisms: infection by free virions and the direct cell-to-cell transmission. We conduct the local and global stability analysis of the model. We show that if the basic reproduction number R0 1, the virus is cleared and the disease dies out; if R0 > 1, the virus persists in the host. We also prove that the unique positive equilibrium attracts all positive solutions under additional assumptions on the parameters. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HIV%20virus%20model" title="HIV virus model">HIV virus model</a>, <a href="https://publications.waset.org/abstracts/search?q=cell-to-cell%20transmission" title=" cell-to-cell transmission"> cell-to-cell transmission</a>, <a href="https://publications.waset.org/abstracts/search?q=global%20stability" title=" global stability"> global stability</a>, <a href="https://publications.waset.org/abstracts/search?q=Lyapunov%20function" title=" Lyapunov function"> Lyapunov function</a>, <a href="https://publications.waset.org/abstracts/search?q=second%20compound%20matrices" title=" second compound matrices"> second compound matrices</a> </p> <a href="https://publications.waset.org/abstracts/23412/global-analysis-of-hiv-virus-models-with-cell-to-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23412.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">517</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1324</span> Impact of Totiviridae L-A dsRNA Virus on Saccharomyces Cerevisiae Host: Transcriptomic and Proteomic Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Juliana%20Luk%C5%A1a">Juliana Lukša</a>, <a href="https://publications.waset.org/abstracts/search?q=Bazil%C4%97%20Ravoityt%C4%97"> Bazilė Ravoitytė</a>, <a href="https://publications.waset.org/abstracts/search?q=Elena%20Servien%C4%97"> Elena Servienė</a>, <a href="https://publications.waset.org/abstracts/search?q=Saulius%20Serva"> Saulius Serva</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Totiviridae L-A virus is a persistent Saccharomyces cerevisiae dsRNA virus. It encodes the major structural capsid protein Gag and Gag-Pol fusion protein, responsible for virus replication and encapsulation. These features also enable the copying of satellite dsRNAs (called M dsRNAs) encoding a secreted toxin and immunity to it (known as killer toxin). Viral capsid pore presumably functions in nucleotide uptake and viral mRNA release. During cell division, sporogenesis, and cell fusion, the virions remain intracellular and are transferred to daughter cells. By employing high throughput RNA sequencing data analysis, we describe the influence of solely L-A virus on the expression of genes in three different S. cerevisiae hosts. We provide a new perception into Totiviridae L-A virus-related transcriptional regulation, encompassing multiple bioinformatics analyses. Transcriptional responses to L-A infection were similar to those induced upon stress or availability of nutrients. It also delves into the connection between the cell metabolism and L-A virus-conferred demands to the host transcriptome by uncovering host proteins that may be associated with intact virions. To better understand the virus-host interaction, we applied differential proteomic analysis of virus particle-enriched fractions of yeast strains that harboreither complete killer system (L-A-lus and M-2 virus), M-2 depleted orvirus-free. Our analysis resulted in the identification of host proteins, associated with structural proteins of the virus (Gag and Gag-Pol). This research was funded by the European Social Fund under the No.09.3.3-LMT-K-712-19-0157“Development of Competences of Scientists, other Researchers, and Students through Practical Research Activities” measure. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=totiviridae" title="totiviridae">totiviridae</a>, <a href="https://publications.waset.org/abstracts/search?q=killer%20virus" title=" killer virus"> killer virus</a>, <a href="https://publications.waset.org/abstracts/search?q=proteomics" title=" proteomics"> proteomics</a>, <a href="https://publications.waset.org/abstracts/search?q=transcriptomics" title=" transcriptomics"> transcriptomics</a> </p> <a href="https://publications.waset.org/abstracts/146170/impact-of-totiviridae-l-a-dsrna-virus-on-saccharomyces-cerevisiae-host-transcriptomic-and-proteomic-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146170.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">146</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1323</span> Chikungunya Virus Infection among Patients with Febrile Illness Attending University of Maiduguri Teaching Hospital, Nigeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdul-Dahiru%20El-Yuguda">Abdul-Dahiru El-Yuguda</a>, <a href="https://publications.waset.org/abstracts/search?q=Saka%20Saheed%20Baba"> Saka Saheed Baba</a>, <a href="https://publications.waset.org/abstracts/search?q=Tawa%20Monilade%20Adisa"> Tawa Monilade Adisa</a>, <a href="https://publications.waset.org/abstracts/search?q=Mustapha%20Bala%20Abubakar"> Mustapha Bala Abubakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Chikungunya (CHIK) virus, a previously anecdotally described arbovirus, is now assuming a worldwide public health burden. The CHIK virus infection is characterized by potentially life threatening and debilitating arthritis in addition to the high fever, arthralgia, myalgia, headache and rash. Method: Three hundred and seventy (370) serum samples were collected from outpatients with febrile illness attending University of Maiduguri Teaching Hospital, Nigeria, and was used to detect for Chikungunya (CHIK) virus IgG and IgM antibodies using the Enzyme Linked Immunosorbent Assays (ELISAs). Result: Out of the 370 sera tested, 39 (10.5%) were positive for presence of CHIK virus antibodies. A total of 24 (6.5%) tested positive for CHIK virus IgM only while none (0.0%) was positive for presence of CHIK virus IgG only and 15 (4.1%) of the serum samples were positive for both IgG and IgM antibodies. A significant difference (p<0.0001) was observed in the distribution of CHIK virus antibodies in relation to gender. The males had prevalence of 8.5% IgM antibodies as against 4.6% observed in females. On the other hand 4.6% of the females were positive for concurrent CHIK virus IgG and IgM antibodies when compared to a prevalence of 3.4% observed in males. Only the age groups ≤ 60 years and the undisclosed age group were positive for presence of CHIK virus IgG and/or IgM antibodies. No significant difference (p>0.05) was observed in the seasonal prevalence of CHIK virus antibodies among the study subjects Analysis of the prevalence of CHIK virus antibodies in relation to clinical presentation (as observed by Clinicians) of the patients revealed that headache and fever were the most frequently encountered ailments. Conclusion: The CHIK virus IgM and concurrent IgM and IgG antibody prevalence rates of 6.5% and 4.1% observed in this study indicates a current infection and the lack of IgG antibody alone observed shows that the infection is not endemic but sporadic. Recommendation: Further studies should be carried to establish the seasonal prevalence of CHIK virus infection vis-à-vis vector dynamics in the study area. A comprehensive study need to be carried out on the molecular characterization of the CHIK virus circulating in Nigeria with a view to developing CHIK virus vaccine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chikungunya%20virus" title="Chikungunya virus">Chikungunya virus</a>, <a href="https://publications.waset.org/abstracts/search?q=IgM%20and%20IgG%20antibodies" title=" IgM and IgG antibodies"> IgM and IgG antibodies</a>, <a href="https://publications.waset.org/abstracts/search?q=febrile%20patients" title=" febrile patients"> febrile patients</a>, <a href="https://publications.waset.org/abstracts/search?q=enzyme%20linked%20immunosorbent%20assay" title=" enzyme linked immunosorbent assay"> enzyme linked immunosorbent assay</a> </p> <a href="https://publications.waset.org/abstracts/57517/chikungunya-virus-infection-among-patients-with-febrile-illness-attending-university-of-maiduguri-teaching-hospital-nigeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57517.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">389</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1322</span> DNA Vaccine Study against Vaccinia Virus Using In vivo Electroporation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jai%20Myung%20Yang">Jai Myung Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Na%20Young%20Kim"> Na Young Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Sung%20Ho%20Shin"> Sung Ho Shin </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The adverse reactions of current live smallpox vaccines and potential use of smallpox as a bioterror weapon have heightened the development of new effective vaccine for this infectious disease. In the present study, DNA vaccine vector was produced which was optimized for expression of the vaccinia virus L1 antigen in the mouse model. A plasmid IgM-tL1R, which contains codon-optimized L1R gene, was constructed and fused with an IgM signal sequence under the regulation of a SV40 enhancer. The expression and secretion of recombinant L1 protein was confirmed in vitro 293 T cell. Mice were administered the DNA vaccine by electroporation and challenged with vaccinia virus. We observed that immunization with IgM-tL1R induced potent neutralizing antibody responses and provided complete protection against lethal vaccinia virus challenge. Isotyping studies reveal that immunoglobulin G2 (IgG2) antibody predominated after the immunization, indicative of a T helper type 1 response. Our results suggest that an optimized DNA vaccine, IgM-tL1R, can be effective in stimulating anti-vaccinia virus immune response and provide protection against lethal orthopoxvirus challenge. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DNA%20vaccine" title="DNA vaccine">DNA vaccine</a>, <a href="https://publications.waset.org/abstracts/search?q=electroporation" title=" electroporation"> electroporation</a>, <a href="https://publications.waset.org/abstracts/search?q=L1R" title=" L1R"> L1R</a>, <a href="https://publications.waset.org/abstracts/search?q=vaccinia%20virus" title=" vaccinia virus"> vaccinia virus</a> </p> <a href="https://publications.waset.org/abstracts/46318/dna-vaccine-study-against-vaccinia-virus-using-in-vivo-electroporation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46318.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">266</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1321</span> Investigation of the Effects of Quercetin on Oxidative Stress in Cells Infected with Infectious Pancreatic Necrosis Virus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dilek%20Zorlu%20Kaya">Dilek Zorlu Kaya</a>, <a href="https://publications.waset.org/abstracts/search?q=Sena%20%C3%87enesiz"> Sena Çenesiz</a>, <a href="https://publications.waset.org/abstracts/search?q=Utku%20Duran"> Utku Duran</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Infectious pancreatic necrosis virus is a disease of great concern in aquaculture, causing mortality of 80 - 90% of the stocks in salmonid production. We aimed to investigate the efficacy of quercetin on oxidant and antioxidant parameters of infectious pancreatic necrosis virus, which is important for fish farming and economy in vitro. Quercetin experimental model was used in the cell culture of Oncorhynchus mykiss infected with infectious pancreatic necrosis virus. Malondialdehyde, ceruloplasmin, total oxidant capacity, total antioxidant levels, and glutathione-peroxidase were measured in the samples. As a result of the study, it was observed that quercetin can minimize the damage caused by scavenging free radicals in cells infected with infectious pancreatic necrosis virus. Thus, we think that an important development can be achieved for fish farming and the economy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=IPNV" title="IPNV">IPNV</a>, <a href="https://publications.waset.org/abstracts/search?q=oncorhynchus%20mykiss" title=" oncorhynchus mykiss"> oncorhynchus mykiss</a>, <a href="https://publications.waset.org/abstracts/search?q=TAS" title=" TAS"> TAS</a>, <a href="https://publications.waset.org/abstracts/search?q=TOS" title=" TOS"> TOS</a>, <a href="https://publications.waset.org/abstracts/search?q=quercetin" title=" quercetin"> quercetin</a> </p> <a href="https://publications.waset.org/abstracts/176688/investigation-of-the-effects-of-quercetin-on-oxidative-stress-in-cells-infected-with-infectious-pancreatic-necrosis-virus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/176688.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">65</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1320</span> The Ebola Virus Disease and Its Outbreak in Nigeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Osagiede%20Efosa%20Kelvin">Osagiede Efosa Kelvin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Ebola virus disease (EVD); also Ebola hemorrhagic fever, is a disease of humans and other primates caused by Ebola viruses. Signs and symptoms typically start between two days and three weeks after contracting the virus as a fever, sore throat, muscle pain, and headaches. Then, vomiting, diarrhoea and rash usually follow, along with decreased function of the liver and kidneys. At this time, some people begin to bleed both internally and externally. The first death in Nigeria was reported on 25 July 2014: a Liberian-American with Ebola flew from Liberia to Nigeria and died in Lagos soon after arrival. As part of the effort to contain the disease, possible contacts were monitored –353 in Lagos and 451 in Port Harcourt On 22 September, the World Health Organisation reported a total of 20 cases, including eight deaths. The WHO's representative in Nigeria officially declared Nigeria Ebola-free on 20 October after no new active cases were reported in the follow-up contact. This paper looks at the Ebola Virus in general and the measures taken by Nigeria to combat its spread. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ebola%20virus" title="Ebola virus">Ebola virus</a>, <a href="https://publications.waset.org/abstracts/search?q=hemorrhagic%20fever" title=" hemorrhagic fever"> hemorrhagic fever</a>, <a href="https://publications.waset.org/abstracts/search?q=Nigeria" title=" Nigeria"> Nigeria</a>, <a href="https://publications.waset.org/abstracts/search?q=outbreak" title=" outbreak"> outbreak</a> </p> <a href="https://publications.waset.org/abstracts/22666/the-ebola-virus-disease-and-its-outbreak-in-nigeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22666.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">503</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1319</span> In vitro Antiviral Activity of Ocimum sanctum against Animal Viruses</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anjana%20Goel">Anjana Goel</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashok%20Kumar%20Bhatia"> Ashok Kumar Bhatia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ocimum sanctum, a well known medicinal plant is used for various alignments in Ayurvedic medicines. It was found to be effective in treating the humans suffering from different viral infections like chicken pox, small pox, measles and influenza. In addition, curative effect of the plant in malignant patients was also reported. In the present study, leaves of this plant were screened against animal viruses i.e. Bovine Herpes Virus-type-1 (BHV-1), Foot and Mouth disease virus (FMDV) and Newcastle Disease Virus (NDV). BHV-1 and FMDV were screened in MDBK and BHK cell lines respectively using cytopathic inhibition test. While NDV was propagated in chick embryo fibroblast culture and tested by haemagglutination inhibition test. Maximum non toxic dose of aqueous extract of Ocimum sanctum leaves was calculated by MTT assay in all the cell cultures and nontoxic doses were used for antiviral activity against viruses. 98.4% and 85.3% protection were recorded against NDV and BHV-1 respectively. However, Ocimum sanctum extract failed to show any inhibitory effect on the cytopathic effect caused by FMD virus. It can be concluded that Ocimum sanctum is a very effective remedy for curing viral infections in animals also. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bovine%20herpes%20virus-type-1" title="bovine herpes virus-type-1">bovine herpes virus-type-1</a>, <a href="https://publications.waset.org/abstracts/search?q=foot%20and%20mouth%20disease%20virus" title=" foot and mouth disease virus"> foot and mouth disease virus</a>, <a href="https://publications.waset.org/abstracts/search?q=newcastle%20disease%20virus" title=" newcastle disease virus"> newcastle disease virus</a>, <a href="https://publications.waset.org/abstracts/search?q=Ocimum%20sanctum" title=" Ocimum sanctum"> Ocimum sanctum</a> </p> <a href="https://publications.waset.org/abstracts/69775/in-vitro-antiviral-activity-of-ocimum-sanctum-against-animal-viruses" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69775.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">271</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1318</span> Negative RT-PCR in a Newborn Infected with Zika Virus: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vallejo%20Michael">Vallejo Michael</a>, <a href="https://publications.waset.org/abstracts/search?q=Acu%C3%B1a%20Edgar"> Acuña Edgar</a>, <a href="https://publications.waset.org/abstracts/search?q=Roa%20Juan%20David"> Roa Juan David</a>, <a href="https://publications.waset.org/abstracts/search?q=Pe%C3%B1uela%20Rosa"> Peñuela Rosa</a>, <a href="https://publications.waset.org/abstracts/search?q=Parra%20Alejandra"> Parra Alejandra</a>, <a href="https://publications.waset.org/abstracts/search?q=Casallas%20Daniela"> Casallas Daniela</a>, <a href="https://publications.waset.org/abstracts/search?q=Rodriguez%20Sheyla"> Rodriguez Sheyla </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Congenital Zika Virus Syndrome is an entity composed by a variety of birth defects presented in newborns that have been exposed to the Zika Virus during pregnancy. The syndrome characteristic features are severe microcephaly, cerebral tissue abnormalities, ophthalmological abnormalities such as uveitis and chorioretinitis, arthrogryposis, clubfoot deformity and muscular tone abnormalities. The confirmatory test is the Reverse transcription polymerase chain reaction (RT-PCR) associated to the physical findings. Here we present the case of a newborn with microcephaly whose mother presented a confirmed Zika Virus infection during the third trimester of pregnancy, despite of the evident findings and the history of Zika infection the RT-PCR in amniotic and cerebrospinal fluid of the newborn was negative. RT-PCR has demonstrated a low sensibility in samples with low viral loads, reason why, we propose a clinical diagnosis in patients with clinical history of Zika Virus infection during pregnancy accompanied by evident clinical manifestations of the child. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=congenital" title="congenital">congenital</a>, <a href="https://publications.waset.org/abstracts/search?q=Zika%20virus" title=" Zika virus"> Zika virus</a>, <a href="https://publications.waset.org/abstracts/search?q=microcephaly" title=" microcephaly"> microcephaly</a>, <a href="https://publications.waset.org/abstracts/search?q=reverse%20transcriptase%20polymerase%20chain%20reaction" title=" reverse transcriptase polymerase chain reaction"> reverse transcriptase polymerase chain reaction</a> </p> <a href="https://publications.waset.org/abstracts/84563/negative-rt-pcr-in-a-newborn-infected-with-zika-virus-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84563.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">211</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1317</span> Inhibition of Mixed Infection Caused by Human Immunodeficiency Virus and Herpes Virus by Fullerene Compound</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dmitry%20Nosik">Dmitry Nosik</a>, <a href="https://publications.waset.org/abstracts/search?q=Nickolay%20Nosik"> Nickolay Nosik</a>, <a href="https://publications.waset.org/abstracts/search?q=Elli%20Kaplina"> Elli Kaplina</a>, <a href="https://publications.waset.org/abstracts/search?q=Olga%20Lobach"> Olga Lobach</a>, <a href="https://publications.waset.org/abstracts/search?q=Marina%20Chataeva"> Marina Chataeva</a>, <a href="https://publications.waset.org/abstracts/search?q=Lev%20Rasnetsov"> Lev Rasnetsov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background and aims: Human Immunodeficiency Virus (HIV) infection is very often associated with Herpes Simplex Virus (HSV) infection but HIV patients are treated with a cocktail of antiretroviral drugs which are toxic. The use of an antiviral drug which will be active against both viruses like ferrovir found in our previous studies is rather actual. Earlier we had shown that Fullerene poly-amino capronic acid (FPACA) was active in case of monoinfection of HIV-1 or HSV-1. The aim of the study was to analyze the efficiency of FPACA against mixed infection of HIV and HSV. Methods: The peripheral blood lymphocytes, CEM, MT-4 cells were simultaneously infected with HIV-1 and HSV-1. FPACA was added 1 hour before infection. Cells viability was detected by MTT assay, virus antigens detected by ELISA, syncytium formation detected by microscopy. The different multiplicity of HIV-1/HSV-1 ratio was used. Results: The double viral HIV-1/HSV-1 infection was more cytopathic comparing with monoinfections. In mixed infection by the HIV-1/HSV-1 concentration of HIV-1 antigens and syncytium formations increased by 1,7 to 2,3 times in different cells in comparison with the culture infected with HIV-1 alone. The concentration of HSV-1 increased by 1,5-1,7 times, respectively. Administration of FPACA (1 microg/ml) protected cells: HIV-1/HSV-1 (1:1) – 80,1%; HIV-1/HSV-1 (1:4) – 57,2%; HIV-1/HSV-1 (1:8) – 46,3 %; HIV-1/HSV-1 (1:16) – 17,0%. Virus’s antigen levels were also reduced. Syncytium formation was totally inhibited in all cases of mixed infection. Conclusion: FPACA showed antiviral activity in case of mixed viral infection induced by Human Immunodeficiency Virus and Herpes Simplex Virus. The effect of viral inhibition increased with the multiplicity of HIV-1 in the inoculum. The mechanism of FPACA action is connected with the blocking of the virus particles adsorption to the cells and it could be suggested that it can have an antiviral activity against some other viruses too. Now FPACA could be considered as a potential drug for treatment of HIV disease complicated with opportunistic herpes viral infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20drug" title="antiviral drug">antiviral drug</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20immunodeficiency%20virus%20%28hiv%29" title=" human immunodeficiency virus (hiv)"> human immunodeficiency virus (hiv)</a>, <a href="https://publications.waset.org/abstracts/search?q=herpes%20simplex%20virus%20%28hsv%29" title=" herpes simplex virus (hsv)"> herpes simplex virus (hsv)</a>, <a href="https://publications.waset.org/abstracts/search?q=mixed%20viral%20infection" title=" mixed viral infection"> mixed viral infection</a> </p> <a href="https://publications.waset.org/abstracts/29635/inhibition-of-mixed-infection-caused-by-human-immunodeficiency-virus-and-herpes-virus-by-fullerene-compound" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29635.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">343</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1316</span> Frequency of Hepatitis C Virus in Diagnosed Tuberculosis Cases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Farooq%20Baig">Muhammad Farooq Baig</a>, <a href="https://publications.waset.org/abstracts/search?q=Saleem%20Qadeer"> Saleem Qadeer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: The frequency of hepatitis C virus infection along with tuberculosis has not been widely investigated and very low statistics on rates of hepatitis C virus co-infection in tuberculosis patients. Hepatotoxicity is the major side effect of anti-tuberculosis therapy hepatitis HCVliver disease elevates the chances of hepatotoxicity up-to five folds. Objectives & Aim: To see the frequency of Hepatitis Cvirus infection amongst people with diagnosed Tuberculosis using gene X-pert technique. To evaluate the factors associated with HCVinfection in patients with MTBtuberculosis and to determine sensitivity and specificity of the tests. Study design: Comparative analytical study. Methodology: Three hundred and thirteen patients of tuberculosis diagnosed by Genexpert included while testing hepatitis C virus using immunochromotography rapid test technique, enzyme linked immunosorbent assay method and polymerase chain reaction test for confirmation. Results:Higher frequency of tuberculosis infection in males 57.8%, 42.5% between 20-39 years and 22% of hepatitis C virus infection in tuberculosis patients.The sensitivity of rapid test and enzyme-linked immunosorbent assay was 79% and 96% respectively while the specificity of rapid test and enzyme-linked immunosorbent assay was 91% and 99% respectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mycobactrium%20Tuberculosis" title="Mycobactrium Tuberculosis">Mycobactrium Tuberculosis</a>, <a href="https://publications.waset.org/abstracts/search?q=PC%27R" title=" PC'R"> PC'R</a>, <a href="https://publications.waset.org/abstracts/search?q=Gene%20x%20pert" title=" Gene x pert"> Gene x pert</a>, <a href="https://publications.waset.org/abstracts/search?q=Hepatitis%20C%20virus" title=" Hepatitis C virus"> Hepatitis C virus</a> </p> <a href="https://publications.waset.org/abstracts/170292/frequency-of-hepatitis-c-virus-in-diagnosed-tuberculosis-cases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170292.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">76</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1315</span> Prevalence Determination of Hepatitis D Virus Genotypes among HBsAg Positive Patients in Kerman Province of Iran</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khabat%20Barkhordari">Khabat Barkhordari</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Mohammad%20Arabzadeh"> Ali Mohammad Arabzadeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hepatitis delta virus (HDV) is a RNA virus that needs the function of hepatitis B virus (HBV) for its propagation and assembly. Infection by HDV can occur spontaneously with HBV infection and cause acute hepatitis or develop as secondary infection in HBV suffering patients. Based on genome sequence analysis, HDV has several genotypes which show broad geographic and diverse clinical features. The aim of current study is determine the prevalence of hepatitis delta virus genotype in patients with positive HBsAg in Kerman province of Iran. This cross-sectional study a total of 400 patients with HBV infection attending the clinic center of Besat from 2012 to 2014 were included. We carried out ELISA to detect anti-HDV antibodies. Those testing positive were analyzed further for HDV-RNA and for genotyping using restriction fragment length polymorphism (RFLP) and RT-nested PCR- sequencing. Among 400 patients in this study, 67 cases (16.75 %) were containing anti-HDV antibody which we found HDV RNA in just 7 (1.75%) serum samples. Analysis of these 7 positive HDV showed that all of them have genotype I. According to current study the HDV prevalence in Kerman is higher than the reported prevalence of 6.6% for Iran as a whole and clade 1 (genotype 1) is the predominant clade of HDV in Kerman. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=genotyping" title="genotyping">genotyping</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatitis%20delta%20virus" title=" hepatitis delta virus"> hepatitis delta virus</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20epidemiology" title=" molecular epidemiology"> molecular epidemiology</a>, <a href="https://publications.waset.org/abstracts/search?q=Kerman" title=" Kerman"> Kerman</a>, <a href="https://publications.waset.org/abstracts/search?q=Iran" title=" Iran"> Iran</a> </p> <a href="https://publications.waset.org/abstracts/36576/prevalence-determination-of-hepatitis-d-virus-genotypes-among-hbsag-positive-patients-in-kerman-province-of-iran" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36576.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1314</span> Infectivity of Glossina pallidipes Salivary Gland Hypertrophy Virus (GpSGHV) to Various Tsetse Species</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Guler%20D.%20Uzel">Guler D. Uzel</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrew%20G.%20Parker"> Andrew G. Parker</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20L.%20Mach"> Robert L. Mach</a>, <a href="https://publications.waset.org/abstracts/search?q=Adly%20Abd-Alla"> Adly Abd-Alla</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Several tsetse fly species (Diptera: Glossinidae) in natural or colonized populations can be infected with the salivary gland hypertrophy virus (SGHV), a circular dsDNA virus (Hytrosaviridae). The virus infection is mainly asymptomatic but, in some species under certain conditions, the infection can produce salivary gland hypertrophy (SGH) symptoms. In the laboratory colonized tsetse, flies with SGH have reduced fertility, which negatively affects colony performance. Therefore, a high prevalence of SGH in insect mass rearing represents a major challenge for tsetse control using the sterile insect technique. The main objective of this study is to analyze the impact of Glossina pallidipes SGHV infection in various tsetse species on mortality and productivity and its impact on the symbiotic bacteria. Hypertropied salivary glands (SG) were collected from G. pallidipes into phosphate buffered saline (PBS) to prepare suspension; 2 µl aliquots were injected into adults of several tsetse species (G. pallidipes (Gp), G. p. gambiensis (Gpg), G. brevipalpis (Gb), G. morsitans morsitans (Gmm), G. morsitans centralis (Gmc) and G. fuscipes (Gf)) and the change in virus and symbiont titers were analyzed using qPCR. The development of SGH in the F1 was detected by dissection 10 days after emergence and virus infection was confirmed by PCR. The impact of virus infection on fly mortality and productivity was recorded. 2 µl aliquots were also injected into 3rd instar larvae of the different species and the adult SGs assayed by PCR for virus. Virus positive SGs from each species were homogenized in PBS and pooled within species for injection into larvae of the same species. Flies injected with PBS were used as control. Injecting teneral flies with SGHV caused increasing virus titer over time in all species but no SGH was detected. Dissection of the F1 also showed no development of SGH except in Gp (the homologous host). Injection of SGHV did not have any impact on the prevalence of the tsetse symbionts, but an increase in Sodalis titer was observed correlated with fly age regardless of virus infection. The virus infection had a negative impact on productivity and mortality. SGHV injection into larvae of the different species produced SGHV infected glands in the adults determined by PCR with a rate of 60%, 27%, 16%, 7% and 7% for Gp, Gf, Gpg, Gmm and Gmc, respectively. Virus positive SGs observed in the heterologous species were smaller than SGH found in Gp. No virus positive SG was detected by PCR in Gb and no SGH was observed in any adults except in Gp. Injecting virus suspension from the virus positive SGs into conspecific larvae did not produce any adults with infected SGs (except in Gp). SGHV can infect all tested tsetse species. Although the virus can infect and increase in titer in other tsetse species and affect fly mortality and productivity, no vertical virus transmission was observed in other tsetse species with might indicate a transmission barrier in these species, and virus collected from flies injected as larvae was not infective by injection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DNA%20viruses" title="DNA viruses">DNA viruses</a>, <a href="https://publications.waset.org/abstracts/search?q=glossina" title=" glossina"> glossina</a>, <a href="https://publications.waset.org/abstracts/search?q=hytrosaviridae" title=" hytrosaviridae"> hytrosaviridae</a>, <a href="https://publications.waset.org/abstracts/search?q=symbiotic%20bacteria" title=" symbiotic bacteria"> symbiotic bacteria</a>, <a href="https://publications.waset.org/abstracts/search?q=tsetse" title=" tsetse"> tsetse</a> </p> <a href="https://publications.waset.org/abstracts/55189/infectivity-of-glossina-pallidipes-salivary-gland-hypertrophy-virus-gpsghv-to-various-tsetse-species" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55189.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">216</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1313</span> Deformed Wing Virus and Varroa Destructor in the Local Honey Bee Colonies Apis mellifera intermissa in Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Noureddine%20Adjlane">Noureddine Adjlane</a>, <a href="https://publications.waset.org/abstracts/search?q=Nizar%20Haddad"> Nizar Haddad </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Deformed Wing Virus (DWV) is considered as the most prevalent virus that dangerous the honeybee health worldwide today. In this study we aimed to evaluate the impact of the virus on honeybees (Apis mellifera intermissa) mortality in Algeria and we conducted the study on samples collected from the central area in the country. We used PCR for the diagnoses of the (DWV) in the diagnosis. The results had shown a high infestation in the sampled colonies and it represented 42% of the total sample. In this study, we found a clear role of both Varroa destructor mite and DWV on hive mortality in the experimented apiary. Further studies need to be conducted in order to give soled recommendations to the beekeepers, decision makers and stockholders of the Algerian beekeeping sector. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=honey%20bee" title="honey bee">honey bee</a>, <a href="https://publications.waset.org/abstracts/search?q=DWV" title=" DWV"> DWV</a>, <a href="https://publications.waset.org/abstracts/search?q=Varroa%20destructor" title=" Varroa destructor"> Varroa destructor</a>, <a href="https://publications.waset.org/abstracts/search?q=mortality" title=" mortality"> mortality</a>, <a href="https://publications.waset.org/abstracts/search?q=prevalence" title=" prevalence"> prevalence</a>, <a href="https://publications.waset.org/abstracts/search?q=infestation" title=" infestation "> infestation </a> </p> <a href="https://publications.waset.org/abstracts/2195/deformed-wing-virus-and-varroa-destructor-in-the-local-honey-bee-colonies-apis-mellifera-intermissa-in-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2195.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">455</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1312</span> The Detection of Antibodies Against Shuni Virus in Cattle From Western Kenya</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Barbra%20Bhebhe">Barbra Bhebhe</a>, <a href="https://publications.waset.org/abstracts/search?q=Melvyn%20Quan"> Melvyn Quan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A serological survey was done to detect antibodies against Shuni virus (SHUV) from cattle in Western Kenya. In Kenya the disease status of SHUV in cattle has never been established. It is a zoonotic virus and even though studies have been carried out as early as the 1960s, little research has been published and SHUV is still not a well-recognised Orthobunyavirus. One hundred serum samples were collected from healthy cattle in Kenya and tested for antibodies against SHUV by a serum neutralization assay. All antibody titre values were greater than 1:160, with most of the samples greater than 1:320. Of the samples tested, 87 % had titres greater than 1:320, 12% had a titre of 1:320 and 2% had a titre of 1:160. Samples were classified as positive if the antibody titre was ≥ 1:10 and negative if < 1:10. This study suggests that cattle are exposed commonly to SHUV, which may be endemic in Kenya. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shuni%20virus" title="Shuni virus">Shuni virus</a>, <a href="https://publications.waset.org/abstracts/search?q=Orthobunyavuruses" title=" Orthobunyavuruses"> Orthobunyavuruses</a>, <a href="https://publications.waset.org/abstracts/search?q=serum%20neutralization%20test" title=" serum neutralization test"> serum neutralization test</a>, <a href="https://publications.waset.org/abstracts/search?q=cell-culture" title=" cell-culture"> cell-culture</a> </p> <a href="https://publications.waset.org/abstracts/161488/the-detection-of-antibodies-against-shuni-virus-in-cattle-from-western-kenya" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/161488.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">75</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1311</span> Molecular Detection of Viruses Causing Hemorrhagic Fevers in Rodents in the South-West of Korea</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sehrish%20Jalal">Sehrish Jalal</a>, <a href="https://publications.waset.org/abstracts/search?q=Choon-Mee%20Kim"> Choon-Mee Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Dong-Min%20Kim"> Dong-Min Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Many pathogens causing hemorrhagic fevers of medical and veterinary importance have been identified and isolated from rodents in the Republic of Korea (ROK). Objective: We investigated the prevalence of emerging viruses causing hemorrhagic fevers, such as hemorrhagic fever with renal syndrome (HFRS), severe fever with thrombocytopenia syndrome (SFTS) and flaviviruses, from wild rodents. Methods: Striped field mice, Apodemus agrarius, (n=39) were captured during 2014-2015 in the south-west of ROK. Using molecular methods, lung samples were evaluated for SFTS virus, HFRS virus and flavivirus, and seropositivity was evaluated in the blood. Results: A high positive rate of Hantavirus (46.2%) was detected in A.agrarius lungs by reverse transcription-nested polymerase chain reaction (RT-N-PCR). The monthly prevalence of HFRS virus was 16.7% in October, 86.7% in November and 25% in August of the following year (p < 0.001). Moreover, 17.9% of blood samples were serologically positive for Hantavirus antibodies. The most prevalent strain in A. agrarius was Hantaan virus. All samples were positive for neither SFTS nor flavivirus. Conclusion: Hantan virus was detected in 86.7% of A. agrarius in November (autumn), and thus, virus shedding from A. agrarius can increase the risk of humans contracting HFRS. These findings may help to predict and prevent disease outbreaks in ROK. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hemorrhagic%20fever%20virus" title="hemorrhagic fever virus">hemorrhagic fever virus</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20diagnostic%20technique" title=" molecular diagnostic technique"> molecular diagnostic technique</a>, <a href="https://publications.waset.org/abstracts/search?q=rodents" title=" rodents"> rodents</a>, <a href="https://publications.waset.org/abstracts/search?q=Korea" title=" Korea"> Korea</a> </p> <a href="https://publications.waset.org/abstracts/101213/molecular-detection-of-viruses-causing-hemorrhagic-fevers-in-rodents-in-the-south-west-of-korea" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/101213.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">159</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1310</span> Multi-Walled Carbon Nanotube Based Water Filter for Virus Pathogen Removal</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Domagala">K. Domagala</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Kata"> D. Kata</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Graule"> T. Graule</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diseases caused by contaminated drinking water are the worldwide problem, which leads to the death and severe illnesses for hundreds of millions million people each year. There is an urgent need for efficient water treatment techniques for virus pathogens removal. The aim of the research was to develop safe and economic solution, which help with the water treatment. In this study, the synthesis of copper-based multi-walled carbon nanotube composites is described. Proposed solution utilize combination of a low-cost material with a high active surface area and copper antiviral properties. Removal of viruses from water was possible by adsorption based on electrostatic interactions of negatively charged virus with a positively charged filter material. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multi%20walled%20carbon%20nanotubes" title="multi walled carbon nanotubes">multi walled carbon nanotubes</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20purification" title=" water purification"> water purification</a>, <a href="https://publications.waset.org/abstracts/search?q=virus%20removal" title=" virus removal"> virus removal</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20treatment" title=" water treatment"> water treatment</a> </p> <a href="https://publications.waset.org/abstracts/106514/multi-walled-carbon-nanotube-based-water-filter-for-virus-pathogen-removal" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106514.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">131</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1309</span> Dual-functional Peptide With Defective Interfering Genes Protecting Mice From Avian and Seasonal Influenza Virus Infection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hanjun%20Zhao">Hanjun Zhao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Limited efficacy of current antivirals and antiviral-resistant mutations impair anti-influenza treatment. Here, we evaluated the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Virus replication was significantly reduced in 293T and A549 cells transfected with DIG-3. Mice transfected with DIG-3 encoded by jetPEI-vector, as prophylaxis and therapeutics against A(H7N7) virus respectively, had significantly better survivals (80% and 50%) than control mice (0%). We further developed a dual-functional peptide TAT-P1, which delivers DIG-3 with high transfection efficiency and concomitantly exerts antiviral activity by preventing endosomal acidification. TAT-P1/DIG-3 was more effective than jetPEI/DIG-3 in treating A(H7N7) or A(H1N1)pdm09-infected mice and showed potent prophylactic protection on A(H7N7) or A(H1N1)pdm09-infected mice. The addition of P1 peptide, preventing endosomal acidification, could enhance the protection of TAT-P1/DIG-3 on A(H1N1)pdm09-infected mice. Dual-functional TAT-P1 with DIG-3 can effectively protect or treat mice infected by avian and seasonal influenza virus infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiviral%20peptide" title="antiviral peptide">antiviral peptide</a>, <a href="https://publications.waset.org/abstracts/search?q=dual-functional%20peptide" title=" dual-functional peptide"> dual-functional peptide</a>, <a href="https://publications.waset.org/abstracts/search?q=defective%20interfering%20genes" title=" defective interfering genes"> defective interfering genes</a>, <a href="https://publications.waset.org/abstracts/search?q=influenza%20virus" title=" influenza virus"> influenza virus</a> </p> <a href="https://publications.waset.org/abstracts/98170/dual-functional-peptide-with-defective-interfering-genes-protecting-mice-from-avian-and-seasonal-influenza-virus-infection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98170.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1308</span> Molecular Epidemiologic Distribution of HDV Genotypes among Different Ethnic Groups in Iran: A Systematic Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khabat%20Barkhordari">Khabat Barkhordari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hepatitis delta virus (HDV) is a RNA virus that needs the function of hepatitis B virus (HBV) for its propagation and assembly. Infection by HDV can occur spontaneously with HBV infection and cause acute hepatitis or develop as secondary infection in HBV suffering patients. Based on genome sequence analysis, HDV has several genotypes which show broad geographic and diverse clinical features. The aim of current study is determine the molecular epidemiology of hepatitis delta virus genotype in patients with positive HBsAg among different ethnic groups of Iran. This systematic review study reviews the results of different studies which examined 2000 Iranian patients with HBV infection from 2010 to 2015. Among 2000 patients in this study, 16.75 % were containing anti-HDV antibody and HDV RNA was found in just 1.75% cases. All of positive cases also have genotype I. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HDV" title="HDV">HDV</a>, <a href="https://publications.waset.org/abstracts/search?q=genotype" title=" genotype"> genotype</a>, <a href="https://publications.waset.org/abstracts/search?q=epidemiology" title=" epidemiology"> epidemiology</a>, <a href="https://publications.waset.org/abstracts/search?q=distribution" title=" distribution "> distribution </a> </p> <a href="https://publications.waset.org/abstracts/37480/molecular-epidemiologic-distribution-of-hdv-genotypes-among-different-ethnic-groups-in-iran-a-systematic-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37480.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">275</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1307</span> Identification of COVID-SARS Variants Based on Lactate Test Results</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zoltan%20Horvath">Zoltan Horvath</a>, <a href="https://publications.waset.org/abstracts/search?q=Dora%20Nagy"> Dora Nagy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this research, it was examined whether individual COVID variants cause differences in the lactate curve of cyclists. After all, the virus variants attacked different organs in our body during the infections. During our tests, we used a traditional lactate step test, the results of which were compared with the values before the infection. In the tests, it has been proven that different virus variants show unique lactate curves. In this way, based on the lactate curve, it is possible to identify which variant caused the disease. Thanks to this, it has been shorten the return time, because we can apply the best return protocol after infection to the competitors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=COVID-Sars19" title="COVID-Sars19">COVID-Sars19</a>, <a href="https://publications.waset.org/abstracts/search?q=lactate" title=" lactate"> lactate</a>, <a href="https://publications.waset.org/abstracts/search?q=virus%20mutation" title=" virus mutation"> virus mutation</a>, <a href="https://publications.waset.org/abstracts/search?q=lactate%20profile" title=" lactate profile"> lactate profile</a> </p> <a href="https://publications.waset.org/abstracts/171056/identification-of-covid-sars-variants-based-on-lactate-test-results" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171056.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">66</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1306</span> The Prevalence of Blood-Borne Viral Infections among Autopsy Cases in Jordan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emad%20Al-Abdallat">Emad Al-Abdallat</a>, <a href="https://publications.waset.org/abstracts/search?q=Faris%20G.%20Bakri"> Faris G. Bakri</a>, <a href="https://publications.waset.org/abstracts/search?q=Azmi%20Mahafza"> Azmi Mahafza</a>, <a href="https://publications.waset.org/abstracts/search?q=Rayyan%20Al%20Ali"> Rayyan Al Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Nidaa%20Ababneh"> Nidaa Ababneh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Idhair"> Ahmed Idhair </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Morgues are high-risk areas for the spread of infection from the cadavers to the staff during the postmortem examination. Infection can spread from corpses to workers by the airborne route, by direct contact, or from needle and sharp object injuries. Objective: Knowledge about the prevalence of these infections among autopsies is prudent to appreciate any risk of transmission and to further enforce safety measures. Method: A total of 242 autopsies were tested. Age ranged from 3 days to 94 years (median 75.5 years, mean 45.3 (21.9 ± SD)). There were 172 (71%) males. Results: The cause of death was considered natural in 137 (56.6%) cases, accidental in 89 (36.8%), homicidal in 9 (3.7%), suicidal in 4 (1.7%), and unknown in 3 (1.2%). Hepatitis B surface antigen was positive in 5 (2.1%) cases. Hepatitis C virus antibody was detected in 5 (2.1%) cases and the hepatitis C virus polymerase chain reaction was positive in 2 of them (0.8%). HIV antibody was not detected in any of the cases. Conclusions: Autopsies can be associated with exposure to blood borne viruses. Autopsies performed during the study period were tested for hepatitis B surface antigen, hepatitis C virus antibody, and human immunodeficiency virus antibody. Positive tests were subsequently confirmed by polymerase chain reaction. There is low prevalence of infections with these viruses in our autopsy cases. However, the risk of transmission remains a threat. Healthcare workers in the forensic departments should adhere to standard precautions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autopsy" title="autopsy">autopsy</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatitis%20B%20virus" title=" hepatitis B virus"> hepatitis B virus</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatitis%20C%20virus" title=" hepatitis C virus"> hepatitis C virus</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20immunodeficiency%20virus" title=" human immunodeficiency virus"> human immunodeficiency virus</a>, <a href="https://publications.waset.org/abstracts/search?q=Jordan" title=" Jordan"> Jordan</a> </p> <a href="https://publications.waset.org/abstracts/52932/the-prevalence-of-blood-borne-viral-infections-among-autopsy-cases-in-jordan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52932.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">379</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1305</span> Changed Behavior of the Porcine Hemagglutinating Encephalomyelitis Virus (Betacoronavirus) in Respiratory Epithelial Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ateeqa%20Aslam">Ateeqa Aslam</a>, <a href="https://publications.waset.org/abstracts/search?q=Hans%20J.%20Nauwynck"> Hans J. Nauwynck</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Porcine hemagglutinating encephalomyelitis virus (PHEV) is a betacoronavirus that has been studied in the past as a cause of vomiting and wasting disease (VWD) in young piglets (<3 weeks). Nowadays, the virus is still circulating on most farms in Belgium, but there are no descriptions anymore of VWD. Therefore, we are interested in differences between the old and new strains. We compared the replication kinetics of the old well-studied strain VW572 (1972) and the recent isolate P412 (2020) in a susceptible continuous cell line (RPD cells) and in primary porcine respiratory epithelial cells (PoRECs). The RPD cell line was inoculated with each PHEV strain at an m.o.i. of 1 the supernatant was collected, and the cells were fixed at different time points post-inoculation. The supernatant was titrated (extracellular virus titer), and the infected cells were revealed by immunofluorescence staining and quantitated by fluorescence microscopy. We found that VW572 replicated better in the RPD cell line at earlier time points when compared to P412. Porcine respiratory epithelial cells (PoREC) were isolated, grown at air-liquid interphase in transwells and inoculated with both strains of PHEV at a virus titer of 106.6TCID50 per 200 µl either at the apical side or at the basal side of the cells. At different time points after inoculation, the transwells were fixed and stained for infected cells. VW572 preferentially infected the epithelial cells via the basolateral side of porcine nasal epithelial cells, whereas P412 preferred the apical side. These findings suggest that there has been an evolution of PHEV in its interaction with the respiratory epithelial cells. In the future, more virus strains will be enclosed and the tropism of the strains for different neuronal cell types will be examined for the change in virus neurotropism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=porcine%20hemagglutinating%20encephalomyelitis%20virus%20%28PHEV%29" title="porcine hemagglutinating encephalomyelitis virus (PHEV)">porcine hemagglutinating encephalomyelitis virus (PHEV)</a>, <a href="https://publications.waset.org/abstracts/search?q=primary%20porcine%20respiratory%20epithelial%20cells%20%28PoRECs%29" title=" primary porcine respiratory epithelial cells (PoRECs)"> primary porcine respiratory epithelial cells (PoRECs)</a>, <a href="https://publications.waset.org/abstracts/search?q=virus%20tropism" title=" virus tropism"> virus tropism</a>, <a href="https://publications.waset.org/abstracts/search?q=vomiting%20and%20wasting%20disease%20%28VWD%29" title=" vomiting and wasting disease (VWD)"> vomiting and wasting disease (VWD)</a> </p> <a href="https://publications.waset.org/abstracts/186511/changed-behavior-of-the-porcine-hemagglutinating-encephalomyelitis-virus-betacoronavirus-in-respiratory-epithelial-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186511.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">59</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=John%20Cunningham%20virus&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=John%20Cunningham%20virus&page=3">3</a></li> <li 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