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bannerWrapper bg-center " style="background-image: url(https://innovation.uci.edu/wp-content/uploads/2023/08/the_hybrid_operating_room_Perceptive-Medical.png)"> <div class="hidden 2lg:block"> </div> <div @resize.window="resize" class="banner "> <div class="banner-color opacity-70" style="background-color: #0065a5;"></div> <div class="banner-inner"> <div class="mb-3.5 md:mb-7 2lg:mb-0"> <a href="https://innovation.uci.edu/category/advancing/" class="btn btn-sm transition text-gray-750 hover:text-gray-700 bg-yellow-450 hover:bg-gray-750btn btn-sm transition text-gray-750 hover:text-gray-700 bg-yellow-450 hover:bg-gray-750 mr-4"> Advancing Towards Market </a> <a href="https://innovation.uci.edu/category/startups-uci/" class="btn btn-sm transition text-gray-100 hover:text-gray-100 bg-orange-450 hover:bg-orange-500btn btn-sm transition text-gray-100 hover:text-gray-100 bg-orange-450 hover:bg-orange-500 mr-4"> UCI Startup </a> </div> <div style="color: #ffffff;"> <div class="banner-title font-normal"> How Might Automation Assist Surgical Outcomes? </div> <div class="banner-body "> <p>UC Irvine startup Perceptive Medical seeks to positively affect 250 million surgical procedures per year by automating drug delivery.</p> </div> </div> </div> </div> <div class="banner-image relative"> <div class="block 2lg:hidden"> </div> <img src="https://innovation.uci.edu/wp-content/uploads/2023/08/the_hybrid_operating_room_Perceptive-Medical.png" alt=""> </div> </div> </div> <div class="wysiwyg-container text-gray-750 mx-8 sm:mx-0 lg:ml-16 xl:ml-0 col-start-1 sm:col-start-2 col-end-6 lg:col-start-1 xl:col-start-2 lg:col-end-4 mt-20"> <div class="info-content text-blue-700">UC Irvine startup Perceptive Medical seeks to positively affect 250 million surgical procedures per year by automating drug delivery.</div> <div class="info-content text-sm">By Jill Kato, August 11, 2023</div> </div> <style> .wysiwyg-container a { color: rgba(5, 100, 163, var(--tw-text-opacity)) !important; } </style> <div class="wysiwyg-container text-gray-750 col-start-1 mx-8 sm:mx-0 sm:col-start-2 col-end-6 lg:col-start-5 lg:col-end-9 xl:col-end-8 lg:mr-1/6 xl:mr-0 mt-20 row-span-2"> <div class="text-blue-700"><strong>Your coffee maker is automated, your car has cruise control, and even your dryer knows when your clothes are ready. So why isn’t something as important and vital as managing your blood pressure not automated?</p> <p>Meet Perceptive Medical, the company revolutionizing patient care by automating blood pressure control during surgery and in the intensive care unit (ICU). Led by visionary founders Joseph Rinehart, M.D., and Maxime Cannesson, M.D., Ph.D., Perceptive Medical is transforming healthcare through automation.</strong></div> <p> </p> <p><strong>Under Pressure</strong></p> <p>“This company grew out of looking at the literature about where there’s evidence about harm, but where our practice lags behind,” says Rinehart, an associate professor of anesthesiology and vice chair for research at UCI’s School of Medicine.</p> <p>Rinehart and the Perceptive Medical team are currently developing a device, a closed-loop vasopressor system, that not only monitors a patient’s blood pressure but adjusts medication automatically. The analogy Rinehart likes to use to explain the need for his device is baking in an oven.</p> <p>“If you wanted to bake chocolate chip cookies, you’d set your oven to 350 degrees and expect the temperature to remain there,” he explains. “But the current practice is as if we’re manually lighting a fire, blowing it out, and then watching a thermometer.”</p> <p>In this analogy, Rinehart is trying to invent the automated oven.</p> <p> </p> <p><strong>Unleashing the Power of Automation</strong></p> <p>We already know that the duration and degree of a patient’s hypotension (low blood pressure) increases the likelihood of catastrophic events (such as a heart attack, stroke, kidney injury, or septic shock). We also know the time spent in hypotension is cumulative and results in bad outcomes. But studies show that even when medical providers are informed of their patients’ hypotension, the frequency and severity of these occurrences don’t decrease.</p> <p>To put it simply, during surgery, an anesthesia provider is busy. They have multiple simultaneous care tasks involving medication, ventilation, fluid management, and tracking the progress of the procedure, and sustained attention to a non-cognitive task like adjusting a rate in response to blood pressure is not a human strong suit. It is, however, something that computer systems do very well, and that can both improve performance as well as free up the anesthesia provider for more high-level strategic tasks. Adjusting patients’ drug infusion rates is far from an anesthesiologist’s only task. Plus, human labor is expensive and inconsistent. And like anything that is manually maintained, there’s a potential for human error.</p> </div> <style> .wysiwyg-container a { color: rgba(5, 100, 163, var(--tw-text-opacity)) !important; } </style> <div id="" class="col-start-1 px-8 sm:col-start-2 sm:px-0 col-end-5 sm:col-end-6 lg:col-start-5 lg:col-end-9 xl:col-end-8 lg:mr-16 xl:mr-0 "> <div class="quote-block"> <div class="info-content text-xl text-blue-700">“It’s not that providers don’t know or don’t care, but they have a lot of competing tasks. This is why we thought this could be an area where we could help both providers and patients.”</div> <div class="info-content text-xl">– Joseph Rinehart, M.D.</div> </div> </div> <div class="wysiwyg-container text-gray-750 col-start-1 mx-8 sm:mx-0 sm:col-start-2 col-end-6 lg:col-start-5 lg:col-end-9 xl:col-end-8 lg:mr-1/6 xl:mr-0 mb-12 row-span-2 "> <p>But what if a human didn’t have to adjust a patient’s medication? What if a machine without any competing duties could carry out this task and improve patient outcomes at the same time? Perceptive Medical’s early results have demonstrated that this is exactly what they’ve been able to do. Their prototype has significantly reduced the time a patient spends in hypotension during and after surgery. Their device leaves medical providers in control while freeing up their time.</p> </div> <style> .wysiwyg-container a { color: rgba(5, 100, 163, var(--tw-text-opacity)) !important; } </style> <div class="mt-small-whitespace lg:mt-0 col-start-1 px-8 sm:col-start-2 sm:px-0 col-end-5 sm:col-end-6 lg:col-start-5 lg:col-end-9 xl:col-end-8 lg:mr-16 xl:mr-0 "> <figure class="post-image"> <img alt=" " src="https://innovation.uci.edu/wp-content/uploads/2023/08/Perceptive-Medical-precision-quotev2.png" > <figcaption class="leading-caption"> </figcaption> </figure> </div> <div class="wysiwyg-container text-gray-750 mx-8 sm:mx-0 lg:ml-16 xl:ml-0 col-start-1 sm:col-start-2 col-end-6 lg:col-start-1 xl:col-start-2 lg:col-end-4 mt-12 p-12 bg-blue-250 "> <div class="info-content text-blue-700"><strong>Proof of Product calibrates and accelerates the pathway to market for promising UCI discoveries</strong></div> <p>Proof of Product is a transformative resource for UC Irvine researchers, designed to infuse use-inspiration and critical funds into commercially promising research projects. Through rigorous review, feedback and selection by domain experts, researchers can seek up to $100,000 in critical funding to advance commercialization. This crucial support underwrites a spectrum of activities, including customer discovery efforts, feasibility studies, and prototype development. These pivotal phases of commercial validation enhance a project’s appeal to investors and refine its marketability with industry partners.</p> <p>For more information about Proof of Product, please visit: <a href="https://innovation.uci.edu/pop-grants/" target="blank">https://innovation.uci.edu/pop-grants/</a></p> <div class="info-content text-blue-700"><strong>Cove Fund: Investing in Innovation</strong></div> <p>Cove Fund is a seed-stage venture capital fund that provides seed-stage investments to power Southern California innovation. The fund is headquartered in “The Cove” at UC Irvine Beall Applied Innovation. The fund invests in early-stage technology and life science companies that demonstrate the potential to address large markets with highly differentiated products and services, and that can achieve significant value-creating inflection points with their seed funding.</p> <p>For more information about Cove Fund, please visit: <a href="https://www.covefund.com/" target="blank">https://www.covefund.com/</a></p> </div> <style> .wysiwyg-container a { color: rgba(5, 100, 163, var(--tw-text-opacity)) !important; } </style> <div class="wysiwyg-container text-gray-750 col-start-1 mx-8 sm:mx-0 sm:col-start-2 col-end-6 lg:col-start-5 lg:col-end-9 xl:col-end-8 lg:mr-1/6 xl:mr-0 mb-large-whitespace mt-12 row-span-2 "> <p><strong>Pumping Innovation and Investor Confidence</strong></p> <p>Rinehart is no stranger to startups. He’s launched multiple companies as a faculty member from UCI and believes the university provides a strong framework for innovation.</p> <p>“UCI has done a good job of growing the startup ecosystem,” Rinehart says. “What you receive is worth much more than what the university asks for in return. I’ve used many of the available resources and some of my time as a faculty member to build something. That’s pretty incredible. What other job can you do that?”</p> <p>Another vital part of the startup ecosystem is funding. Procuring enough funding to get a startup up and running can feel a bit like a Catch-22. You must prove to investors that your technology has commercial promise, but in order to produce the evidence to convince them, you need money.</p> <p>This is where UCI’s <a href="https://innovation.uci.edu/pop-grants/" target="blank"><u>Proof of Product (PoP)</u></a> grant, distributed through UCI Beall Applied Innovation plays a pivotal function in the early stages of a startup. Beall provides often hard-to-procure seed funding to propel start-ups past the idea stage. The PoP grants help de-risk commercially promising technology by showing “proof of product” for larger investors and granting agencies down the road.</p> <p>Rinehart received a PoP grant for Perceptive Medical, as well as a UC Center for Accelerated Innovation grant. He used the funds to hire engineers to create the initial design for patent filing.</p> <p>“The first thing investors want to know is whether you have a patent. UCI will pay for the filing of the patents, but you need funds to pay for the expertise to develop those patents. You can’t just submit a drawing on the back of a napkin,” Rinehart explains.</p> <p>Last year was an especially stressful year financially for many in the startup world. According to Rinehart, fundraising has been Perceptive Medical’s biggest challenge so far. Fortunately, the <a href="https://www.covefund.com/" target="blank"><u>Cove Fund</u></a>, a seed-stage venture capital fund headquartered in “The Cove” at UCI Beall Applied Innovation came through as an anchor investor and helped Perceptive Medical get over this funding hump.</p> <p> </p> <p><strong>Unlocking Personalized Target Research</strong></p> <p>“Rinehart is aiming to start a clinical trial under FDA IDE approval next year with a commercial-ready system. (Class III is the highest risk category for devices approved by the FDA. Pacemakers and heart valves fall in this category.) The level of regulatory scrutiny Perceptive Medical will undergo will be intense. But through it all, Rinehart maintains his sense of humor.</p> <p>“I think for my next company, I want to do something totally unregulated, like a holiday village. I could put some LEDs in a house and sell it. Maybe I’ll go with Halloween villages first. Halloween is way more fun than Christmas anyway,” he says.</p> <p>Halloween villages aside, Rinehart hopes to collect data from his clinical study next year and later apply for FDA approval. Not only will he and the Perceptive Medical team make monumental strides with their closed-loop vasopressor, but the data they collect may have even larger implications for patient health. With the data Perceptive Medical’s device collects, they will be able to open the doors for creating personalized target research for blood pressure.</p> <p>“We will be able to answer questions about what blood pressure is best for patients with a degree of certainty that hasn’t been possible before,” he says.</p> <p>Discover More at: <a href="https://www.perceptivemedical.com/">https://www.perceptivemedical.com/</a></p> </div> <style> .wysiwyg-container a { color: rgba(5, 100, 163, var(--tw-text-opacity)) !important; } </style> </div> </main> <footer class="bg-gray-750 py-10 text-white px-12 lg:px-6 xl:px-12 pt-24 lg:pt-64"> <p class="font-bold mb-8">You've Come This Far, <span class="whitespace-nowrap">Now Go All the Way</span></p> <div class="menu-footer-container grid grid-cols-1 md:grid-cols-2 lg:grid-cols-5 mb-8 lg:gap-4 xl:gap-0"> <div class="order-first"> <div class="mb-8"> <a href="https://techtransfer.universityofcalifornia.edu/default.aspx?campus=IR" 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