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class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-1087 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="1087"><div class="fl-row fl-row-fixed-width fl-row-bg-photo fl-node-z1yikvgne4s9 fl-row-default-height fl-row-align-center" data-node="z1yikvgne4s9"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-5a7uh0r8mw9b" data-node="5a7uh0r8mw9b"> <div class="fl-col fl-node-0tpfwrbegd7h fl-col-bg-color" data-node="0tpfwrbegd7h"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-jy4061am2uln" data-node="jy4061am2uln"> <div class="fl-module-content fl-node-content"> <h1 class="fl-heading"> <span class="fl-heading-text">SCIENTIFIC PROGRAM DAY ONE</span> </h1> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-none fl-node-5ea190634c344 fl-row-default-height fl-row-align-center" data-node="5ea190634c344"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-gw6akp431t0b" data-node="gw6akp431t0b"> <div class="fl-col fl-node-adk0onswrz8j fl-col-bg-color" data-node="adk0onswrz8j"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-separator fl-node-i489lfy2w3ot" data-node="i489lfy2w3ot"> <div class="fl-module-content fl-node-content"> <div class="fl-separator"></div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-5ea190634dbab" data-node="5ea190634dbab"> <div class="fl-col fl-node-5ea190634dce9 fl-col-bg-color fl-col-small" data-node="5ea190634dce9"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-5ea1906a0f7f4" data-node="5ea1906a0f7f4"> <div class="fl-module-content fl-node-content"> <a href="https://worldadc-usa.com/program/conferences-days/conference-day-one/" id="ee-link-5ea1906a0f7f4"> <div class="eehw-link"> <div class="link-url"> <h2>Day One </h2> </div> <div class="link-date"> <p>Tuesday | November 5, 2024</p> </div> </div> </a> </div> </div> </div> </div> <div class="fl-col fl-node-5ea190634dcf6 fl-col-bg-color fl-col-small" data-node="5ea190634dcf6"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-5ea1907f4ad61" data-node="5ea1907f4ad61"> <div class="fl-module-content fl-node-content"> <a href="https://worldadc-usa.com/program/conferences-days/conference-day-two/" id="ee-link-5ea1907f4ad61"> <div class="eehw-link"> <div class="link-url"> <h2>Day Two </h2> </div> <div class="link-date"> <p>Wednesday | November 6, 2024</p> </div> </div> </a> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-5ea1b25b0039b" data-node="5ea1b25b0039b"> <div class="fl-col fl-node-5ea1b25b00488 fl-col-bg-color" data-node="5ea1b25b00488"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-mdxlefryp4j3" data-node="mdxlefryp4j3"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 7:00 am </span> Check In, Morning Coffee & Refreshments </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 7:55 am </span> Chair’s Opening Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker23661" class="view-speaker" speaker-id="23661"><span>Robert Lutz</span></a></em> Chief Scientific Officer, Iksuda Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #990582;">Moving the Needle Forward in 2024 & Beyond: What are the Next ADCs to Re-Shape the Field?</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:00 am </span> Panel Discussion: Contextualizing the Ongoing Growth & Success of the ADC Field & Envisioning the Best Route Forward for ADC Innovation </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22296" class="view-speaker" speaker-id="22296"><span>Jeffrey Settleman</span></a></em> Senior Vice President, Chief Scientific Officer, Oncology R&D, Pfizer </li> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22298" class="view-speaker" speaker-id="22298"><span>Shawn Zhang</span></a></em> Chief Scientific Officer, Ambrx, a Johnson & Johnson Company </li> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22300" class="view-speaker" speaker-id="22300"><span>Puja Sapra</span></a></em> Senior Vice President, Biologics Engineering & Oncology Targeted Discovery, Oncology R&D, AstraZeneca </li> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22302" class="view-speaker" speaker-id="22302"><span>Mary Jane Hinrichs</span></a></em> Senior Vice President, Global Head of Early Development, Ipsen Pharma </li> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22304" class="view-speaker" speaker-id="22304"><span>Scott peterson</span></a></em> Head of ADC discovery, Pfizer </li> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker23661" class="view-speaker" speaker-id="23661"><span>Robert Lutz</span></a></em> Chief Scientific Officer, Iksuda Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Reflecting on the past and envisioning the future of the ADC field: spanning upcoming approvals, exciting targets, novel linker-payloads, conjugation technologies, and combination therapies</li> <li>Deep-diving into recent clinical trials – what ADCs have broken the perceived clinical expectations for success?</li> <li>Debating rationale of going after new targets and using novel payloads against iteratively improving the validated successes in the field – what are predictions for the next ADC breakthrough?</li> <li>Diversifying your ADC portfolio across indications, targets, and ADC components to be on top of the next wave of ADC innovation</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:00 am </span> From IND to Long Term Commercial Supply: a Step Ahead Against the Challenges of the Bioconjugates </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22289" class="view-speaker" speaker-id="22289"><span>Maria Elena Guadagno</span></a></em> Technical Operations & Business Executive Director, BSP Pharmaceuticals S.p.A </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Exploring a sustainable business model</li> <li>Discussing expertise, technology and integration of services</li> <li>Examining capacity shortage challenges: what it means going forward? </li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> TROP2 ADC Development: Exploring the Datopotamab Deruxtecan Mechanism, Clinical Efficacy, & Future Directions </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22279" class="view-speaker" speaker-id="22279"><span>Ricardo Zwirtes</span></a></em> Executive Director, Global Clinical Lead, Daiichi Sankyo, Inc. </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Delving into the intricacies of Dato-DXd mechanism of action and the innovative approach in developing ADCs with the DXd linker-payload technology</li> <li>Examining the comprehensive late-stage clinical data for Dato-DXd, highlighting its clinical efficacy and safety profile </li> <li>Discussing the critical insights gained from the development of Dato-DXd, and outline the strategic next steps for its clinical application and further development</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:00 am </span> Morning Break & Networking </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>As the ADC community is reunited all under one roof at the world’s leading and biggest industry forum, use this valuable time to reconnect with your peers, meet fresh faces, and visit exhibitor booths to make new and lasting scientific and business “linkers” with the wide range of attendees. This is a dedicated time to have face-to-face interaction with many of the brightest minds working in the ADC field and establish meaningful relationships – don’t forget to enjoy some refreshments before we split off into the six conference tracks.</p> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-am560g2ld97r" data-node="am560g2ld97r"> <div class="fl-col fl-node-6ikn9bqwhc73 fl-col-bg-color" data-node="6ikn9bqwhc73"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-tabs fl-node-puwycd25g7is" data-node="puwycd25g7is"> <div class="fl-module-content fl-node-content"> <div class="fl-tabs fl-tabs-vertical fl-clearfix"> <div class="fl-tabs-labels fl-clearfix" role="tablist"> <a href="#" class="fl-tabs-label fl-tab-active" id="fl-tabs-puwycd25g7is-label-0" data-index="0" aria-selected="true" aria-controls="fl-tabs-puwycd25g7is-panel-0" aria-expanded="true" role="tab" tabindex="0"> <span style="font-size: 18px; color: #ac7194;"><strong>Discovery Chemistry</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-puwycd25g7is-label-1" data-index="1" aria-selected="false" aria-controls="fl-tabs-puwycd25g7is-panel-1" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #2B2A87;"><strong>Cellular Biology</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-puwycd25g7is-label-2" data-index="2" aria-selected="false" aria-controls="fl-tabs-puwycd25g7is-panel-2" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #E31E26;"><strong>Translational</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-puwycd25g7is-label-3" data-index="3" aria-selected="false" aria-controls="fl-tabs-puwycd25g7is-panel-3" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #015FAE;"><strong>Clinical Lessons</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-puwycd25g7is-label-4" data-index="4" aria-selected="false" aria-controls="fl-tabs-puwycd25g7is-panel-4" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #973E97;"><strong>Process & Analytical Development</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-puwycd25g7is-label-5" data-index="5" aria-selected="false" aria-controls="fl-tabs-puwycd25g7is-panel-5" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #656568;"><strong>Manufacturing & Supply Chain</strong></span> </a> </div> <div class="fl-tabs-panels fl-clearfix"> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label fl-tab-active" data-index="0" tabindex="0"> <span><span style="font-size: 18px; color: #ac7194;"><strong>Discovery Chemistry</strong></span></span> <i class="fas"></i> </div> <div class="fl-tabs-panel-content fl-clearfix fl-tab-active" id="fl-tabs-puwycd25g7is-panel-0" data-index="0" aria-labelledby="fl-tabs-puwycd25g7is-label-0" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #ac7194;"><strong>Discovery Chemistry</strong></span></p> <p style="text-align: center;"><strong>Chair</strong>: <em><strong>Thomas Nittoli</strong>, Senior Director, <strong>Regeneron</strong></em></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-usa.com/about/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="color: #000000;"><strong>Optimizing the Classics & Exploring Next Generation ADC Payloads to Guide ADC Chemistry & Design</strong></span></p> <hr /> <p><span style="color: #ac7194;"><strong>11.00 am</strong></span><strong> Evaluating Design & Optimization of Novel Exatecanbased Payloads</strong></p> <p><span style="color: #ac7194;"><strong>Paul <span style="color: #ac7194;">Hogg</span></strong>, Vice President, </span><span style="color: #ac7194;">Medicinal & Protein Chemistry, </span><strong><span style="color: #ac7194;">ADC Therapeutics</span></strong></p> <hr /> <p><strong><span style="color: #ac7194;">11.30 am<span style="color: #000000;"> Improved Efficacy & Reduced Toxicity of ADCs With OHPAS Linker, PMT, & Nexatecan<br /> </span></span></strong></p> <p><span style="color: #ac7194;"><strong>Yosup Rew</strong>, Chief Technology Officer,<strong> IntoCell</strong></span></p> <hr /> <p><strong><span style="color: #ac7194;">12.00 pm</span> Introduction to </strong><strong>Radioconjugates & the Promise </strong><strong>of Theranostics for the Delivery </strong><strong>of Molecularly Targeted </strong><strong>Radiation</strong></p> <p><span style="color: #ac7194;"><strong><span style="color: #ac7194;">Frank</span> Comer</strong>, Director, Tumor Targeted Delivery, Early Oncology Discovery,<strong> AstraZeneca </strong></span></p> <hr /> <p><strong><span style="color: #ac7194;">12.30 pm</span> Development of a Site Specific & Versatile Conjugation Approach Based on Bacterial Transglutaminase & the Diels-Alder Cycloaddition Reaction </strong></p> <p><strong><span style="color: #ac7194;">Francisco Velasquez</span></strong><span style="color: #ac7194;">, Senior Director, Chemistry,</span><strong><span style="color: #ac7194;"> Abzena</span></strong></p> <hr /> <p><span style="color: #f9af1f;"><strong>1.00 pm Lunch & Learn Presented By <span style="color: #000000;">Millipore Sigma</span></strong></span></p> <hr /> <p style="text-align: center;"><strong>Leveraging Novel Conjugation </strong><strong>Chemistries for Site-Specific </strong><strong>Conjugation</strong></p> <hr /> <p><strong><span style="color: #ac7194;">2.00 pm</span> Highlighting Novel Conjugation Technologies Spearheading the Transition Away From Stochastic Conjugation</strong></p> <p><span style="color: #ac7194;"><strong>Sayumi Yamazoe</strong>, Associate Director, ADC Discovery, <strong>Bristol Myers Squibb</strong></span></p> <hr /> <p><strong><span style="color: #ac7194;">2.30 pm</span> Leveraging Cell-Free Protein Synthesis for SiteSpecific Conjugation to Enhance ADC Therapeutic Index</strong></p> <p><span style="color: #ac7194;"><strong>Gang <span style="color: #ac7194;">Yin</span></strong>, Vice President, Research, <strong>Sutro Biopharma</strong></span></p> <hr /> <p><span style="color: #ac7194;"><strong>3.00 pm </strong></span><strong>Targeting TYRP-1 in Malignant Melanoma: Novel mavg-MMAU Linker-Payload Improves Both Efficacy & Tolerability of Auristatin ADCs </strong></p> <p><span style="color: #ac7194;"><strong>Juhani Saarinen</strong>, Chief Executive Officer, <strong>Glykos Finland Oy</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="1" tabindex="0"> <span><span style="font-size: 18px; color: #2B2A87;"><strong>Cellular Biology</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-puwycd25g7is-panel-1" data-index="1" aria-hidden="true" aria-labelledby="fl-tabs-puwycd25g7is-label-1" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #2b2a87;"><strong>Cellul<span style="color: #2b2a87;">a</span>r <span style="color: #2b2a87;">B</span>iology</strong></span></p> <p style="text-align: center;"><em><strong>Chair: Kevin Hamblett</strong></em>, Senior Director, ADC Biology, <strong>Pfizer</strong></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-usa.com/about/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><strong>ADC Target Showcase & Investigation for Novel Therapeutic Development</strong></p> <hr /> <p><strong><span style="color: #2b2a87;">11.00 am</span> Targeting Mesenchymal Tumors With a Novel Antibody Drug Conjugate</strong></p> <p><strong><span style="color: #2b2a87;">Martin Steegmaier</span></strong><span style="color: #2b2a87;"><em><span style="color: #2b2a87;">, Chief</span> Scientific Officer,</em></span> <strong><span style="color: #2b2a87;">SOTIO Biotech</span></strong></p> <hr /> <p><strong><span style="color: #2b2a87;">11.30 am</span> Opening the Barn Door to ADC Discovery</strong></p> <p><span style="color: #2b2a87;"><strong>Eric Vajda</strong>, Vice President, Preclinical R&D, <strong>OmniAb</strong></span></p> <hr /> <p><strong><span style="color: #2b2a87;">12.00 pm</span> Showcasing ADC </strong><strong>Development Against Claudin </strong><strong>Family Targets – Claudin 6 & </strong><strong>Claudin 18</strong></p> <p><strong><span style="color: #2b2a87;">Martina McDermott</span></strong><span style="color: #2b2a87;">, Adjunct </span><span style="color: #2b2a87;">Assistant Professor,</span><strong><span style="color: #2b2a87;"> UCLA</span></strong></p> <hr /> <p><span style="color: #2b2a87;"><strong>12.30 pm</strong></span> <strong>Accelerating Bispecific Discovery With the Alloy Common Light Chain Fully Human Transgenic Mouse Platform</strong></p> <p><strong><span style="color: #2b2a87;">Mike Schmidt</span></strong><span style="color: #2b2a87;">, Chief Scientific Officer, </span><strong><span style="color: #2b2a87;">Alloy Therapeutics</span></strong></p> <hr /> <p><strong><span style="color: #f9af1f;">1.00 pm Lunch & Learn Presented By <span style="color: #000000;">Millipore Sigma</span></span></strong></p> <hr /> <p style="text-align: center;"><strong>Bispecific ADCs: Navigating Mechanistic & Translational Development</strong></p> <hr /> <p><strong><span style="color: #2b2a87;">2.00 pm</span> Showcasing Development </strong><strong>& Potential of a Bispecific ADC </strong><strong>vs Traditional ADCs</strong></p> <p><strong><span style="color: #2b2a87;">Jinwon Jung</span></strong><span style="color: #2b2a87;">, Senior Director, </span><span style="color: #2b2a87;">Protein Engineering, </span><strong><span style="color: #2b2a87;">ABL Bio</span></strong></p> <hr /> <p><strong><span style="color: #2b2a87;">2.30 pm</span> Highlighting Discovery & Non-Clinical Development of EGFR-B7H3 Bispecific ADC</strong></p> <p><strong><span style="color: #2b2a87;">Kaijie He</span></strong><span style="color: #2b2a87;">, Vice President, Head of </span><span style="color: #2b2a87;">Cancer Biology & ADC, </span><strong><span style="color: #2b2a87;">Innovent Biologics</span></strong></p> <hr /> <p><strong><span style="color: #2b2a87;">3.00 pm</span> A Translational Approach to ADC Evaluation: From In Vitro Organoids to Advanced In Vivo Models</strong></p> <p><span style="color: #2b2a87;"><strong>Simon Jiang</strong>, Vice President, Biology, <strong>Lide Biotech</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="2" tabindex="0"> <span><span style="font-size: 18px; color: #E31E26;"><strong>Translational</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-puwycd25g7is-panel-2" data-index="2" aria-hidden="true" aria-labelledby="fl-tabs-puwycd25g7is-label-2" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #e31e26;"><strong><span style="color: #e31e26;">Tr</span>anslational</strong></span></p> <p style="text-align: center;"><strong>Chair: Rakesh Dixit</strong>, President & Chief Executive Officer, <strong>Bionavigen Oncology</strong></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-usa.com/about/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><strong>Evaluating Best-in-Class Translational Studies to Inform ADC Preclinical Development</strong></p> <hr /> <p><span style="color: #e31e26;"><strong>11.00 am</strong></span> <strong>Raludotatug Deruxtecan (R DXd), a Cadherin-6-directed ADC With a DNA Topoisomerase I Inhibitor DXd</strong></p> <p><span style="color: #e31e26;"><strong>Shotaro Nagase</strong>, Researcher, Discovery Research Laboratories I, <strong>Daiichi Sankyo</strong></span></p> <hr /> <p><span style="color: #e31e26;"><strong>11.30 am</strong></span> <strong>Expanding ADC Therapeutic Index Through Site-Specific Bioconjugation & Tumor Selective Payload Release & Activation</strong></p> <p><strong><span style="color: #e31e26;">Stephen Slocum</span></strong><span style="color: #e31e26;">, Director, Drug Development, Project Lead,</span><strong><span style="color: #e31e26;"> LigaChem Biosciences</span></strong></p> <hr /> <p><strong><span style="color: #e31e26;">12.00 pm</span> Preclinical Development of a Novel PBD-Based ADC Against CD45 for Antigen Specific Depletion of Hematopoietic Stem Cells & Hematological Malignancies</strong></p> <p><strong><span style="color: #e31e26;">Patrick Van Berkel</span></strong><span style="color: #e31e26;">, Chief Scientific Officer,</span> <strong><span style="color: #e31e26;">ADC Therapeutics</span></strong></p> <hr /> <p><span style="color: #e31e26;"><strong>12.30 pm</strong></span><strong> Catalent SMARTag® ADCs: Innovating What’s Next </strong></p> <p><strong><span style="color: #e31e26;">Stepan Chuprakov, </span></strong><span style="color: #e31e26;">Director of Chemistry</span><strong><span style="color: #e31e26;">, Catalent Pharma Solutions</span></strong></p> <hr /> <p><strong><span style="color: #f9af1f;">1.00 pm Lunch & Learn Presented By <span style="color: #000000;">Millipore Sigma</span></span></strong></p> <hr /> <p style="text-align: center;"><strong>Getting on Top of ADC Safety & Efficacy Characterization to Maximize Translation </strong></p> <hr /> <p><strong><span style="color: #e31e26;">2.00 pm</span> Characterizing ADC Safety & Activity in Preclinical Development of STRO-004</strong></p> <p><strong><span style="color: #e31e26;">Alice Yam</span></strong><span style="color: #e31e26;">, Vice President, Drug Discovery,</span><strong><span style="color: #e31e26;"> Sutro Biopharma</span></strong></p> <hr /> <p><strong><span style="color: #e31e26;">2.30 pm</span> Translational Strategies </strong><strong>Towards the Derivation of a </strong><strong>Therapeutic Index for Early </strong><strong>ADCs</strong></p> <p><span style="color: #e31e26;"><strong>Christina Vasalou</strong>, Director, Head of ADC Translational PKPD, <strong>AstraZeneca</strong></span></p> <hr /> <p><strong><span style="color: #e31e26;">3.00 pm</span> Next-Generation Bioconjugate Therapeutics: Driving Innovation with Revolutionary Conjugation Technologies</strong></p> <p><span style="color: #e31e26;"><strong>Paul Song</strong>, Chief Scientific Officer,<strong> GeneQuantum Healthcare</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="3" tabindex="0"> <span><span style="font-size: 18px; color: #015FAE;"><strong>Clinical Lessons</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-puwycd25g7is-panel-3" data-index="3" aria-hidden="true" aria-labelledby="fl-tabs-puwycd25g7is-label-3" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #015fae;"><strong>Clini<span style="color: #015fae;">c</span>al Lessons</strong></span></p> <p style="text-align: center;"><strong><em>Chair: Patrick Zweidler-McKay</em></strong>, Executive Medical Director, <strong>AbbVie </strong></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-usa.com/about/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><strong>Showcasing Cutting-Edge Clinical Development of Latestage ADC Candidates</strong></p> <hr /> <p><strong><span style="color: #015fae;">11.00</span> Showcasing Clinical Update & Learnings for Luvelta Targeting Folate Receptor Alpha</strong></p> <p><span style="color: #015fae;"><strong>Hanspeter Gerber,</strong> Chief Scientific Officer<strong>, Sutro Biopharma</strong></span></p> <hr /> <p><span style="color: #015fae;"><strong>11.30</strong></span><strong> AI Spatial Biomarkers & Diagnostics for ADC Patient Selection </strong></p> <p><strong><span style="color: #015fae;">Jason Reeves</span></strong><span style="color: #015fae;">, Director, Application Science,</span><strong><span style="color: #015fae;"> Nucleai</span></strong></p> <hr /> <p><strong><span style="color: #015fae;">12.00</span> Evaluating the Breadth & Depth of I-DXd (Anti-B7-H3 ADC) Efficacy in Solid Tumors</strong></p> <p><span style="color: #015fae;"><strong>Caleb Lee</strong>, Executive Director,<strong> Daiichi <span style="color: #015fae;">Sankyo</span></strong></span></p> <hr /> <p><strong><span style="color: #015fae;">12.30 pm</span> Breaking Down Expanded Clinical Data of ABBV-400 ADC Targeting c-Met</strong></p> <p><span style="color: #015fae;"><strong>Hua Fang</strong>, Scientific Director, Clinical Development Oncology,<strong> AbbVie</strong></span></p> <hr /> <p><strong><span style="color: #f9af1f;">1.00 pm Lunch & Learn Presented By <span style="color: #000000;">Millipore Sigma</span></span></strong></p> <hr /> <p style="text-align: center;"><strong>Putting the Why Behind Performance in the Clinic to Set Up Early ADC Development for Success</strong></p> <hr /> <p><strong><span style="color: #015fae;">2.00 pm</span> Track Resumes at 2:30pm<br /> </strong></p> <hr /> <p><strong><span style="color: #015fae;">2.30 pm</span> Development of MYTX011, a cMET ADC: Initial Dose Escalation Results from Phase 1 KisMET-01 Study</strong></p> <p><span style="color: #015fae;"><strong><span style="color: #015fae;">G</span>illes <span style="color: #015fae;">Gallant</span></strong>, Chief Development Officer, <strong>Mythic Therapeutics</strong></span></p> <hr /> <p><span style="color: #015fae;"><strong>3.00 pm</strong> </span><strong>Advantages of Clinical-Stage GlycoConnectTM Platform Technology – Successful Application for Multiple Targets & with Different Payload Classes</strong></p> <p><strong><span style="color: #015fae;">Anette Sommer</span></strong><span style="color: #015fae;">, Head of Biochemistry, </span><strong><span style="color: #015fae;">Synaffix</span></strong></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="4" tabindex="0"> <span><span style="font-size: 18px; color: #973E97;"><strong>Process & Analytical Development</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-puwycd25g7is-panel-4" data-index="4" aria-hidden="true" aria-labelledby="fl-tabs-puwycd25g7is-label-4" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #973e97;"><strong>Proc<span style="color: #973e97;">es</span>s & Analytical Development</strong></span></p> <p style="text-align: center;"><strong><em>Chair: </em></strong><strong><em>Lisa McDermott</em></strong>, Director, Process & Analytical Development,<strong><br /> MilliporeSigma</strong></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-usa.com/about/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><strong>Analytical Technologies & Applications: Tackling Characterization of Complex ADC Molecules</strong></p> <hr /> <p><strong><span style="color: #973e97;">11.00 am</span> Assessing Analytical Methods for ADC DAR Characterization & Control Strategy</strong></p> <p><span style="color: #973e97;"><strong>Yuan Ren</strong>, Principal Scientist, Chemical Process Development, Analytical Chemistry, <strong>Bristol Myers Squibb</strong></span></p> <hr /> <p><strong><span style="color: #973e97;">11.30 am</span> Bringing Novel ADC Formats into the Clinic: Insights from the Process Development of Oligonucleotide Conjugates </strong></p> <p><strong><span style="color: #973e97;">Hanna Wagner</span></strong><span style="color: #973e97;">, Supervisor, Process Development Bioconjugates,</span> <strong><span style="color: #973e97;">Lonza</span></strong></p> <hr /> <p><strong><span style="color: #973e97;">12.00 pm</span></strong> <strong>Leveraging Machine Learning Models to Predict ADC Post-Translational Modifications</strong></p> <p><span style="color: #973e97;"><strong>Nicole Swope</strong>, Senior Scientist, Analytical Sciences, <strong>AstraZeneca</strong></span></p> <hr /> <p><span style="color: #973e97;"><strong>12.30 pm</strong></span> <strong>Phase- & Product-Appropriate Bioconjugate Development</strong></p> <p><strong><span style="color: #973e97;">Conor Barry</span></strong><span style="color: #973e97;">, Associate Vice President, Global Biologics Technical Lead, </span><strong><span style="color: #973e97;">Piramal Pharma Solutions</span></strong></p> <hr /> <p><strong><span style="color: #f9af1f;">1.00 pm Lunch & Learn Presented By <span style="color: #000000;">Millipore Sigma</span></span></strong></p> <hr /> <p style="text-align: center;"><strong>Characterizing & Controlling Impurities to Improve ADC Quality</strong></p> <hr /> <p><span style="color: #973e97;"><strong>2.00</strong></span> <strong>Undergoing Deep ADC Characterization to Identify Low-Abundance Conjugatable Impurities</strong></p> <p><strong><span style="color: #973e97;">Yuanyuan Li</span></strong><span style="color: #973e97;">, Director,</span><strong><span style="color: #973e97;"> Mersana Therapeutics</span></strong></p> <hr /> <p><span style="color: #973e97;"><strong>2.30</strong></span> <strong>Characterizing ADC Positional Isomers to Achieve a Deeper Understanding of ADC Products</strong></p> <p><strong><span style="color: #973e97;">Zhengqi Zhang</span></strong><span style="color: #973e97;">, Senior Scientist, </span><strong><span style="color: #973e97;">Merck & Co</span></strong></p> <hr /> <p><strong><span style="color: #973e97;">3.00</span> Leveraging Orthogonal icIEF-UV/MS & LC-MS Workflows for Comprehensive Characterization of Antibody-Drug Conjugates</strong></p> <p><strong><span style="color: #973e97;">Haichuan Liu</span></strong><span style="color: #973e97;">, Manager, Strategic Marketing, Protein Characterization, </span><strong><span style="color: #973e97;">SCIEX</span></strong></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="5" tabindex="0"> <span><span style="font-size: 18px; color: #656568;"><strong>Manufacturing & Supply Chain</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-puwycd25g7is-panel-5" data-index="5" aria-hidden="true" aria-labelledby="fl-tabs-puwycd25g7is-label-5" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #656568;"><strong>Manufacturing & Supply Chain</strong></span></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-usa.com/about/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><strong>Exploring Strategies & Risk Assessments for ADC Manufacturing & Development</strong></p> <hr /> <p><span style="color: #656568;"><strong>11.00 am</strong></span> <strong>Exploring Technical Challenges & Opportunities in Early-Stage ADC Development & Manufacturing</strong></p> <p><span style="color: #656568;"><strong>Engin Ayturk</strong>, Senior Director, CMC Bioconjugation, Process Development & Manufacturing, <strong>Exelixis</strong></span></p> <hr /> <p><strong><span style="color: #656568;">11.30 am</span> Assessing the Capabilities of CMOs/CDMOs for Safely Handling Payloads & ADCs for Worker & Product Protection Purposes</strong></p> <p><span style="color: #656568;"><strong>Allan Ader</strong>, Managing Director, <strong>SafeBridge Consultants</strong></span></p> <hr /> <p><span style="color: #973e97;"><strong><span style="color: #656568;">12.00 am</span> <span style="color: #000000;">Taking on Risk Factors in ADC Manufacturing – How Much is Acceptable?</span></strong></span></p> <p><span style="color: #656568;"><strong>Esohe Idusogie</strong>, Head, Process Quality & CMC Analytical ADC Therapeutics, <strong>ADC Therapeutics</strong></span></p> <hr /> <p><span style="color: #656568;"><strong>12.30 pm</strong></span><strong><span style="color: #000000;"> Empowering Successful Bioconjugation Manufacturing with Process Technology Innovation</span></strong></p> <p><strong><span style="color: #656568;">Yuhua Hu</span></strong><span style="color: #656568;">, Head, US-EU CMC Management,</span><strong><span style="color: #656568;"> WuXi XDC</span></strong></p> <hr /> <p><span style="color: #f9af1f;"><strong>1.00 pm</strong> <strong>Lunch & Learn Presented By <span style="color: #000000;">Millipore Sigma</span></strong></span></p> <hr /> <p style="text-align: center;"><strong>Efficiently Juggling the Pieces to Achieve Smooth ADC Supply Chain</strong></p> <hr /> <p><strong><span style="color: #656568;">2.00 pm <span style="color: #000000;">Assessing Drug-Linker Manufacturing & Supply to Ensure Upfront Development Under Accelerated IND Timelines</span></span></strong></p> <p><span style="color: #656568;"><strong>Candice Wong</strong>, Senior Director, Engineering & External Process Development, <strong>Pfizer</strong></span></p> <hr /> <p><strong><span style="color: #656568;">2.30 pm</span> Roundtable Discussion: Assessing Bottlenecks & Opportunities to Streamline ADC Manufacturing Across Multiple Outsourced Partners</strong></p> <hr /> <p><span style="color: #656568;"><strong>3.00 pm <span style="color: #000000;">ProveoTM, an Integrated Supply Chain for ADCs: From Development to Commercial Manufacturing</span></strong></span></p> <p><strong><span style="color: #656568;">Vitor Sousa</span></strong><span style="color: #656568;">, Director, Business Development, </span><strong><span style="color: #656568;">Proveo</span></strong></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-ghebzs1vrxdu" data-node="ghebzs1vrxdu"> <div class="fl-col fl-node-s8e6ncpm0bxy fl-col-bg-color" data-node="s8e6ncpm0bxy"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-v54zai3spjyg" data-node="v54zai3spjyg"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:30 pm </span> Afternoon Break & Technology Slam<br><br>By Beacon, Quantum Si, Sony </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>As you enjoy your afternoon refreshments, you will also have the chance to be face-to-face with the field’s most innovative and exciting technology providers. Join our dedicated technology slam to identify your next technology provider and progress your antibody-drug conjugate pipeline smoothly and efficiently</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #990582;">What Makes a Clinically Effective ADC? Breaking Down Recent ADC Clinical Performance></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> Technical Excellence in Development and Manufacturing of BioConjugates </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker23915" class="view-speaker" speaker-id="23915"><span>Gary Conway</span></a></em> Principal Production Scientist, GMP Manufacturing, Merck KGaA </li> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker25358" class="view-speaker" speaker-id="25358"><span>Yomadis Ortiz</span></a></em> Manager, Process and Analytical Development, Merck KGaA </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Introduction of the techniques used during development to achieve deep process understanding and right first time transfer to Manufacturing</li> <li>Explore the established roadmap to scale up at an experienced ADC manufacturer</li> <li>Learn through case studies : seamless transfers from process and analytical development to GMP production</li> </ul> <p></p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:00 pm </span> Exploring Learnings From Translational & Clinical Development of Dolaflexin & Dolasynthen ADCs </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker22323" class="view-speaker" speaker-id="22323"><span>Timothy Lowinger</span></a></em> Chief Science & Technology Officer, Mersana Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Contrasting and sharing pre-clinical and clinical data for Dolaflexin and Dolasynthen ADCs, employing the same payload and same antibody</li> <li>Predicting and evaluating differences in clinical efficacy and tolerability performance based on preclinical data – what are the core lessons?</li> <li>Breaking down how differences in ADC design impact clinical performance</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:30 pm </span> Accelerating Novel ADC Development through WuXi XDC’s Innovative Technology & Integrated Development/Manufacturing Platform </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker25619" class="view-speaker" speaker-id="25619"><span>Marie Zhu</span></a></em> Chief Technology Officer, WuXi Biologics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Learning how 5 of 13 approved ADCs use random cysteine conjugation with MMAE, capped at 2 mg/kg to avoid TEAEs </li> <li>Discussing how WuXiDAR4's proprietary technology creates ADCs with a narrowly distributed DAR for enhanced efficacy and safety, eliminating the need to modify monoclonal antibodies or any enzymes, simplifying the process and reducing costs of goods </li> <li>Outlining how WuXi XDC CDMO platform integrates the development and manufacturing of monoclonal antibody intermediates, payload linkers, conjugation, and drug products, expediting development from DNA to IND in under 15 months with over 60 successful IND submissions</li> <li>Leveraging deep expertise and comprehensive manufacturing, WuXi XDC offers a clear strategy to secure successful BLA filings for its clients</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 6:00 pm </span> Reflecting On Phase I Termination of DHES0815A: What Were the Core Lessons Learned? </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker23286" class="view-speaker" speaker-id="23286"><span>Gail Lewis</span></a></em> Senior Principal Scientist, Genentech </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Breaking down ADC design, preclinical development, and phase I clinical trial results</li> <li>What were the main takeaways from observed clinical toxicities?</li> <li>Striving for transparency on ADC clinical trial results regardless of outcome</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 6:30 pm </span> Chair’s Closing Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-usa.com/speakers/#speaker23661" class="view-speaker" speaker-id="23661"><span>Robert Lutz</span></a></em> Chief Scientific Officer, Iksuda Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #f0f0f0"> <h3> <span class="time"> 6:30 pm </span> Scientific Poster Session & Drinks Reception <br> Hosted by AsymBio </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>This is a great opportunity to showcase your latest work and get face-to-face time with attending audience of ADC experts, as well as finding out insights from ongoing ADC development by your peers. In an informal setting, you will be able to discuss, debate, and display your work in the field while enjoying a drink of your choice at our dedicated drinks reception.</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 7:30 pm </span> End of Scientific Program Day One </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-j7mtyri8bgnl fl-row-default-height fl-row-align-center" data-node="j7mtyri8bgnl"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-3owqlytbna6z" data-node="3owqlytbna6z"> <div class="fl-col fl-node-cyo6x53mp9bg fl-col-bg-color fl-col-small" data-node="cyo6x53mp9bg"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-button fl-node-5x8b2fi4vj96" data-node="5x8b2fi4vj96"> 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rel="noopener">Beacon</a></td> <p></tr> <p></p> <tr></p> <td style="width: 94.7px;"><a href="https://hansonwade.com/searchlight-life-sciences-networking-events/" target="_blank" rel="noopener">Searchlight</a></td> <p></p> <td style="width: 94.7px;"><a href="https://hansonwade.com/intelligence-life-sciences-consultancy/" target="_blank" rel="noopener">Intelligence</a></td> <p></tr> <p></tbody> <p></table> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-color fl-node-as7plnuijqhy fl-row-default-height fl-row-align-center" data-node="as7plnuijqhy"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-gvixzofwa4bj" data-node="gvixzofwa4bj"> <div class="fl-col fl-node-8o5uyna1q0g6 fl-col-bg-color fl-col-has-cols" data-node="8o5uyna1q0g6"> <div class="fl-col-content fl-node-content"> <div class="fl-col-group fl-node-jmwpc3z1ies9 fl-col-group-nested" data-node="jmwpc3z1ies9"> <div class="fl-col fl-node-nl90i72m6gea fl-col-bg-color" data-node="nl90i72m6gea"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-rich-text fl-node-bluhpvga5dez" data-node="bluhpvga5dez"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p>A Hanson Wade Group Company</p> </div> </div> </div> </div> </div> <div class="fl-col fl-node-27c9drj3tkgx fl-col-bg-color fl-col-small" data-node="27c9drj3tkgx"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-photo fl-node-1jq47zaf593l" data-node="1jq47zaf593l"> <div class="fl-module-content fl-node-content"> <div class="fl-photo fl-photo-align-right" itemscope itemtype="https://schema.org/ImageObject"> <div class="fl-photo-content fl-photo-img-png"> <a href="https://hansonwadegroup.com/" target="_blank" rel="noopener" itemprop="url"> <img loading="lazy" decoding="async" class="fl-photo-img wp-image-18434 size-full" src="https://eehw.net/images/HWG-1-1.png" alt="HWG" itemprop="image" height="176" width="300" title="HWG" /> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-color fl-node-r7xzovgpecys fl-row-default-height fl-row-align-center" data-node="r7xzovgpecys"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-6wjgtpkxne9i" data-node="6wjgtpkxne9i"> <div class="fl-col fl-node-hyikfcujpr09 fl-col-bg-color" data-node="hyikfcujpr09"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-rich-text fl-node-fx74hkdwe0og" data-node="fx74hkdwe0og"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p><small>© Copyright 2024 Hanson Wade | Design and site by <a href="https://www.eventengine.tv/" target="_blank" rel="noopener">Event Engine</a> | Hanson Wade Limited is registered in England & Wales, number 06752216.<br />Registered Office: Eastcastle House, 27/28 Eastcastle Street, London, W1W 8DH.</small></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </footer> </div> <script type="text/javascript"> // EE Custom Code document.addEventListener('DOMContentLoaded', function() { var url = new URL(window.location.href); // Get current URL var search_params = new URLSearchParams(url.search); // Get URL params // Function to remove the hash from the URL function removeHash() { if (url.hash) { var cleanUrl = window.location.origin + window.location.pathname + window.location.search; history.replaceState(null, null, cleanUrl); url = new URL(cleanUrl); // Update the URL object to the clean URL } } // Remove the hash immediately on page load removeHash(); // Check if UTM params exist if (search_params.has('utm_source') || search_params.has('utm_medium') || search_params.has('utm_campaign') || search_params.has('utm_content')) { var links = 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node.waypoint({offset:offset,handler:FLBuilderLayout._doModuleAnimation});});}},_doModuleAnimation:function(){var module='undefined'==typeof this.element?$(this):$(this.element),delay=parseFloat(module.data('animation-delay')),duration=parseFloat(module.data('animation-duration'));if(!isNaN(duration)){module.css('animation-duration',duration+'s');} if(!isNaN(delay)&&delay>0){setTimeout(function(){module.addClass('fl-animated');},delay*1000);}else{setTimeout(function(){module.addClass('fl-animated');},1);}},_initHash:function(){var hash=window.location.hash.replace('#','').split('/').shift(),element=null,tabs=null,responsiveLabel=null,tabIndex=null,label=null;if(''!==hash){try{element=$('#'+hash);if(element.length>0){if(element.hasClass('fl-accordion-item')){setTimeout(function(){element.find('.fl-accordion-button').trigger('click');},100);} if(element.hasClass('fl-tabs-panel')){setTimeout(function(){tabs=element.closest('.fl-tabs');responsiveLabel=element.find('.fl-tabs-panel-label');tabIndex=responsiveLabel.data('index');label=tabs.find('.fl-tabs-labels .fl-tabs-label[data-index='+tabIndex+']');label[0].click();FLBuilderLayout._scrollToElement(element);},100);}}} catch(e){}}},_initAnchorLinks:function(){$('a').each(FLBuilderLayout._initAnchorLink);},_initAnchorLink:function(){var link=$(this),href=link.attr('href'),loc=window.location,id=null,element=null,flNode=false;if('undefined'!=typeof href&&href.indexOf('#')>-1&&link.closest('svg').length<1){if(loc.pathname.replace(/^\//,'')==this.pathname.replace(/^\//,'')&&loc.hostname==this.hostname){try{id=href.split('#').pop();if(!id){return;} element=$('#'+id);if(element.length>0){flNode=element.hasClass('fl-row')||element.hasClass('fl-col')||element.hasClass('fl-module');if(!element.hasClass('fl-no-scroll')&&(link.hasClass('fl-scroll-link')||flNode)){$(link).on('click',FLBuilderLayout._scrollToElementOnLinkClick);} if(element.hasClass('fl-accordion-item')){$(link).on('click',FLBuilderLayout._scrollToAccordionOnLinkClick);} if(element.hasClass('fl-tabs-panel')){$(link).on('click',FLBuilderLayout._scrollToTabOnLinkClick);}}} catch(e){}}}},_scrollToElementOnLinkClick:function(e,callback){var element=$('#'+$(this).attr('href').split('#').pop());FLBuilderLayout._scrollToElement(element,callback);e.preventDefault();},_scrollToElement:function(element,callback){var config=FLBuilderLayoutConfig.anchorLinkAnimations,dest=0,win=$(window),doc=$(document);if(element.length>0){if('fixed'===element.css('position')||'fixed'===element.parent().css('position')){dest=element.position().top;} else if(element.offset().top>doc.height()-win.height()){dest=doc.height()-win.height();} else{dest=element.offset().top-config.offset;} $('html, body').animate({scrollTop:dest},config.duration,config.easing,function(){if('undefined'!=typeof callback){callback();} if(undefined!=element.attr('id')){if(history.pushState){history.pushState(null,null,'#'+element.attr('id'));} else{window.location.hash=element.attr('id');}}});}},_scrollToAccordionOnLinkClick:function(e){var element=$('#'+$(this).attr('href').split('#').pop());if(element.length>0){var callback=function(){if(element){element.find('.fl-accordion-button').trigger('click');element=false;}};FLBuilderLayout._scrollToElementOnLinkClick.call(this,e,callback);}},_scrollToTabOnLinkClick:function(e){var element=$('#'+$(this).attr('href').split('#').pop()),tabs=null,label=null,responsiveLabel=null;if(element.length>0){tabs=element.closest('.fl-tabs');responsiveLabel=element.find('.fl-tabs-panel-label');tabIndex=responsiveLabel.data('index');label=tabs.find('.fl-tabs-labels .fl-tabs-label[data-index='+tabIndex+']');if(responsiveLabel.is(':visible')){var callback=function(){if(element){responsiveLabel.trigger($.Event('click',{which:1}));}};FLBuilderLayout._scrollToElementOnLinkClick.call(this,e,callback);} else{label[0].click();FLBuilderLayout._scrollToElement(element);} e.preventDefault();}},_initForms:function(){if(!FLBuilderLayout._hasPlaceholderSupport){$('.fl-form-field input').each(FLBuilderLayout._initFormFieldPlaceholderFallback);} $('.fl-form-field input').on('focus',FLBuilderLayout._clearFormFieldError);},_hasPlaceholderSupport:function(){var input=document.createElement('input');return'undefined'!=input.placeholder;},_initFormFieldPlaceholderFallback:function(){var field=$(this),val=field.val(),placeholder=field.attr('placeholder');if('undefined'!=placeholder&&''===val){field.val(placeholder);field.on('focus',FLBuilderLayout._hideFormFieldPlaceholderFallback);field.on('blur',FLBuilderLayout._showFormFieldPlaceholderFallback);}},_hideFormFieldPlaceholderFallback:function(){var field=$(this),val=field.val(),placeholder=field.attr('placeholder');if(val==placeholder){field.val('');}},_showFormFieldPlaceholderFallback:function(){var field=$(this),val=field.val(),placeholder=field.attr('placeholder');if(''===val){field.val(placeholder);}},_clearFormFieldError:function(){var field=$(this);field.removeClass('fl-form-error');field.siblings('.fl-form-error-message').hide();},_initRowShapeLayerHeight:function(){FLBuilderLayout._adjustRowShapeLayerHeight();$(window).on('resize',FLBuilderLayout._adjustRowShapeLayerHeight);},_initNestedColsWidth:function(){var nestedCols=$('.fl-col-has-cols');if(nestedCols.length<=0){return;} $(nestedCols).each(function(index,col){if($(col).width()<=0){$(col).css('width',FLBuilderLayoutConfig.emptyColWidth);}});},_adjustRowShapeLayerHeight:function(){var rowShapeLayers=$('.fl-builder-shape-layer');$(rowShapeLayers).each(function(index){var rowShapeLayer=$(this),shape=$(rowShapeLayer).find('svg'),height=shape.height(),excludeShapes='.fl-builder-shape-circle, .fl-builder-shape-dot-cluster, .fl-builder-shape-topography, .fl-builder-shape-rect';if(!rowShapeLayer.is(excludeShapes)){$(shape).css('height',Math.ceil(height));}});},_string_to_slug:function(str){str=str.replace(/^\s+|\s+$/g,'');if('undefined'==typeof window._fl_string_to_slug_regex){regex=new RegExp('[^a-zA-Z0-9\'":() !.,-_|]','g');}else{regex=new RegExp('[^'+window._fl_string_to_slug_regex+'\'": !.,-_|\\\p{Letter}]','ug');} str=str.replace(regex,'').replace(/\s+/g,' ');return str;},_reorderMenu:function(){if($('#wp-admin-bar-fl-builder-frontend-edit-link-default li').length>1){$('#wp-admin-bar-fl-builder-frontend-duplicate-link').appendTo('#wp-admin-bar-fl-builder-frontend-edit-link-default').css('padding-top','5px').css('border-top','2px solid #1D2125').css('margin-top','5px')}}};$(function(){FLBuilderLayout.init();});})(jQuery);;(function($){FLBuilderTabs=function(settings){this.settings=settings;this.nodeClass='.fl-node-'+settings.id;this.tabsOnMobile=settings.tabsOnMobile;this.activeTab=settings.activeTab;this._init();};FLBuilderTabs.prototype={settings:{},nodeClass:'',_init:function(){var win=$(window);$(this.nodeClass+' .fl-tabs-labels .fl-tabs-label').click($.proxy(this._labelClick,this));$(this.nodeClass+' .fl-tabs-labels .fl-tabs-label').on('keypress',$.proxy(this._labelClick,this));$(this.nodeClass+' .fl-tabs-panels .fl-tabs-label').click($.proxy(this._responsiveLabelClick,this));$(this.nodeClass+' .fl-tabs-panels .fl-tabs-label').on('keypress',$.proxy(this._responsiveLabelClick,this));win.on('resize',$.proxy(this._setupTabs,this));if($(this.nodeClass+' .fl-tabs-vertical').length>0){this._resize();win.off('resize'+this.nodeClass);win.on('resize'+this.nodeClass,$.proxy(this._resize,this));} FLBuilderLayout.preloadAudio(this.nodeClass+' .fl-tabs-panel-content');this._setupTabs();},_labelClick:function(e){var label=$(e.target).closest('.fl-tabs-label'),index=label.data('index'),wrap=label.closest('.fl-tabs'),allIcons=wrap.find('.fl-tabs-panels .fl-tabs-label .fas'),icon=wrap.find('.fl-tabs-panels .fl-tabs-label[data-index="'+index+'"] .fas');if(!this._validClick(e)){return;} allIcons.addClass('fa-plus');icon.removeClass('fa-plus');wrap.find('.fl-tabs-labels:first > .fl-tab-active').removeClass('fl-tab-active').attr('aria-selected','false').attr('aria-expanded','false');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tab-active').removeClass('fl-tab-active');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content').attr('aria-hidden','true').css('display','');wrap.find('.fl-tabs-labels:first > .fl-tabs-label[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-selected','true').attr('aria-expanded','true');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-label[data-index="'+index+'"]').addClass('fl-tab-active');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-hidden','false');FLBuilderLayout.refreshGalleries(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.refreshGridLayout(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.reloadSlider(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.resizeAudio(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));FLBuilderLayout.resizeSlideshow();FLBuilderLayout.reloadGoogleMap(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));e.preventDefault();},_responsiveLabelClick:function(e){var label=$(e.target).closest('.fl-tabs-label'),wrap=label.closest('.fl-tabs'),index=label.data('index'),content=label.siblings('.fl-tabs-panel-content'),activeContent=wrap.find('.fl-tabs-panel-content.fl-tab-active'),activeIndex=activeContent.data('index'),allIcons=wrap.find('.fl-tabs-panels .fl-tabs-label > .fas'),icon=label.find('.fas');if(!this._validClick(e)){return;} if(label.hasClass('fl-tab-active')||wrap.hasClass('fl-tabs-animation')){return;} allIcons.addClass('fa-plus');icon.removeClass('fa-plus');wrap.addClass('fl-tabs-animation');activeContent.slideUp('normal');content.slideDown('normal',function(){wrap.find('.fl-tab-active').removeClass('fl-tab-active').attr('aria-hidden','true');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content').attr('aria-hidden','true');wrap.find('.fl-tabs-label[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-hidden','false');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content[data-index="'+index+'"]').attr('aria-hidden','false');content.addClass('fl-tab-active');wrap.removeClass('fl-tabs-animation');FLBuilderLayout.refreshGalleries(content);FLBuilderLayout.refreshGridLayout(content);FLBuilderLayout.reloadSlider(content);FLBuilderLayout.resizeAudio(content);FLBuilderLayout.reloadGoogleMap(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));if(label.offset().top<$(window).scrollTop()+100){$('html, body').animate({scrollTop:label.offset().top-100},500,'swing');}});},_resize:function(){$(this.nodeClass+' .fl-tabs-vertical').each($.proxy(this._resizeVertical,this));},_resizeVertical:function(e){var wrap=$(this.nodeClass+' .fl-tabs-vertical'),labels=wrap.find('.fl-tabs-labels'),panels=wrap.find('.fl-tabs-panels');panels.css('min-height',labels.height()+'px');},_validClick:function(e){return(e.which==1||e.which==13||e.which==32)?true:false;},_setupTabs:function(){index=this.activeTab-1;if(index<0){index=0;} var winWidth=$(window).width(),activeTabContent=$(this.nodeClass+' .fl-tabs-panel-content.fl-tab-active'),activeTabPanel=activeTabContent.parent(),activeTabLabelIcon=activeTabPanel.find('i'),smallBreakPoint=FLBuilderLayoutConfig.breakpoints.small,mediumBreakPoint=FLBuilderLayoutConfig.breakpoints.medium;if(winWidth<=smallBreakPoint&&'close-all'==this.tabsOnMobile){activeTabContent.hide();activeTabLabelIcon.addClass('fa-plus');activeTabPanel.find('.fl-tab-active').removeClass('fl-tab-active').attr('aria-hidden','true');}else if(winWidth>=smallBreakPoint){activeTabContent.show();activeTabLabelIcon.removeClass('fa-plus');}},};})(jQuery);;(function($){$(function(){new FLBuilderTabs({id:'puwycd25g7is',tabsOnMobile:'open-active',activeTab:'1',});});})(jQuery);;;;jQuery(function($){$(function(){$('.fl-node-jn9zdl60gob5 .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-5cfe705e4d20d .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){FLBuilderMenu=function(settings){this.nodeId=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-menu';this.type=settings.type;this.mobileToggle=settings.mobile;this.mobileBelowRow=settings.mobileBelowRow;this.mobileFlyout=settings.mobileFlyout;this.breakPoints=settings.breakPoints;this.mobileBreakpoint=settings.mobileBreakpoint;this.currentBrowserWidth=$(window).width();this.postId=settings.postId;this.mobileStacked=settings.mobileStacked;this._initMenu();$(window).on('resize',$.proxy(function(e){var width=$(window).width();if(width!=this.currentBrowserWidth){this.currentBrowserWidth=width;this._initMenu();this._clickOrHover();} this._resizeFlyoutMenuPanel();},this));$(window).on('scroll',$.proxy(function(e){this._resizeFlyoutMenuPanel();},this));$('body').on('click',$.proxy(function(e){if('undefined'!==typeof FLBuilderConfig){return;} var activeMobileMenu=$(this.wrapperClass+' .fl-menu-mobile-toggle.fl-active');if(activeMobileMenu.length&&('expanded'!==this.mobileToggle)){$(activeMobileMenu).trigger('click');} $(this.wrapperClass).find('.fl-has-submenu').removeClass('focus');$(this.wrapperClass).find('.fl-has-submenu .sub-menu').removeClass('focus');},this));$(this.wrapperClass+' ul.menu > li:last-child').on('focusout',$.proxy(function(e){if($(this.wrapperClass).find('.fl-menu-mobile-toggle').hasClass('fl-active')&&('expanded'!==this.mobileToggle)){if(!$(e.relatedTarget).parent().hasClass('menu-item')){$(this.wrapperClass).find('.fl-menu-mobile-toggle').trigger('click');}}},this));};FLBuilderMenu.prototype={nodeClass:'',wrapperClass:'',type:'',breakPoints:{},$submenus:null,_isMobile:function(){return this.currentBrowserWidth<=this.breakPoints.small?true:false;},_isMedium:function(){return this.currentBrowserWidth<=this.breakPoints.medium?true:false;},_isLarge:function(){return this.currentBrowserWidth<=this.breakPoints.large?true:false;},_isMenuToggle:function(){if(('always'==this.mobileBreakpoint||(this._isMobile()&&'mobile'==this.mobileBreakpoint)||(this._isMedium()&&'medium-mobile'==this.mobileBreakpoint)||(this._isLarge()&&'large-mobile'==this.mobileBreakpoint))&&($(this.wrapperClass).find('.fl-menu-mobile-toggle').is(':visible')||'expanded'==this.mobileToggle)){return true;} return false;},_initMenu:function(){this._setupSubmenu();this._menuOnFocus();this._menuOnEscape();this._submenuOnClick();if($(this.nodeClass).length&&this.type=='horizontal'){this._initMegaMenus();} if(this._isMenuToggle()||this.type=='accordion'){$(this.wrapperClass).off('mouseenter mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cfe705e4d219',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'198',mobileStacked:true,});});})(jQuery);;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} if(this.hasAdminBar&&this.win.width()<=600){wpAdminBarHeight=Math.floor($('#wpadminbar').outerHeight());} totalHeaderHeight=Math.floor(beforeHeaderHeight+headerHeight);if(headerHeight>0){var headerParent=this.header.parent(),headerParentTopPadding=0;if($(headerParent).is('body')){headerParentTopPadding=Math.floor(headerHeight-wpAdminBarHeight);}else{headerParentTopPadding=Math.floor(headerHeight-bodyTopPadding-wpAdminBarHeight);} $(headerParent).css('padding-top',(headerParentTopPadding-beforeHeaderFix)+'px');this.header.css({'-webkit-transform':'translate(0px, -'+totalHeaderHeight+'px)','-ms-transform':'translate(0px, -'+totalHeaderHeight+'px)','transform':'translate(0px, -'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var image=$(this),maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.css('max-height',shrinkImageHeight);}});this.header.find('.fl-row-content-wrap').each(function(){var row=$(this);if(parseInt(row.css('padding-bottom'))>5){row.addClass('fl-theme-builder-header-shrink-row-bottom');} if(parseInt(row.css('padding-top'))>5){row.addClass('fl-theme-builder-header-shrink-row-top');}});this.header.find('.fl-module-content').each(function(){var module=$(this);if(parseInt(module.css('margin-bottom'))>5){module.addClass('fl-theme-builder-header-shrink-module-bottom');} if(parseInt(module.css('margin-top'))>5){module.addClass('fl-theme-builder-header-shrink-module-top');}});}}else if(hasClass){this.header.find('img').css('max-height','');this._removeShrink();} 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