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class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Mohamed Ibrahim" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/6545678/9701899/10806044/s200_mohamed.ibrahim.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Mohamed Ibrahim</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://cardiff.academia.edu/">Cardiff University</a>, <a class="u-tcGrayDarker" href="https://cardiff.academia.edu/Departments/GIS_and_RS/Documents">GIS and RS</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/26174861/extraction_and_identification_of_gelatin">extraction and identification of gelatin</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://kau.academia.edu/BasitMariod">Basit Mariod</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39730b001aacc0cdff6d47af24534d27" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46501012,"asset_id":26174861,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46501012/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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The two insects showed 27.0 and 28.2% crude protein, respectively. Extraction of gelatin using hot water gave high yield followed by mild acid and distilled water extraction, respectively. SDS-PAGE pattern showed low molecular weight chains, and the two gelatins contained protein with molecular weight of 40 kDa as main component. The differential scanning calorimetry thermograms results confirm no difference between extraction methods concerning the extracted gelatin quality. FTIR spectra of melon and sorghum bug gelatins were similar and the absorption bands were situated in more than 6 bands in melon bug gelatin and only 6 bands in sorghum bug gelatin. Amide II bands of gelatins from both melon and sorghum bug appeared at around 1554 cm -1 , while Amide I bands (1734-1632 cm -1 ) appeared only in melon bug method 2 (MB2) and melon bug method3 (MB3). Microstructures of the insect gelatin examined with the scanning electron microscope showed that melon bug exhibited the finest gelatin network with very small voids. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15339879"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15339879/%CE%B1_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_%CE%BAB_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo"><img alt="Research paper thumbnail of 伪-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-魏B and Hsp70 protein modulation in vitro, and tumor reduction in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/43319190/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15339879/%CE%B1_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_%CE%BAB_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo">伪-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-魏B and Hsp70 protein modulation in vitro, and tumor reduction in vivo</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NajihahHashim10">Najihah Hashim</a></span></div><div class="wp-workCard_item"><span>Drug design, development and therapy</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. In the current ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. In the current study, 伪-Mangostin (AM) was isolated and its cell death mechanism was studied. HCS was undertaken to detect the nuclear condensation, mitochondrial membrane potential, cell permeability, and the release of cytochrome c. An investigation for reactive oxygen species formation was conducted using fluorescent analysis. To determine the mechanism of cell death, human apoptosis proteome profiler assay was conducted. In addition, using immunofluorescence and immunoblotting, the levels of Bcl-2-associated X protein (Bax) and B-cell lymphoma (Bcl)-2 proteins were also tested. Caspaces such as 3/7, 8, and 9 were assessed during treatment. Using HCS and Western blot, the contribution of nuclear factor kappa-B (NF-魏B) was investigated. AM had showed a selective cytotoxicity toward the cancer cells with no toxicity toward the normal cells even at 30 渭g/mL, thereby indicating that AM has the attribute...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23eb534c18d9988eb5451ff27d187a2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43319190,"asset_id":15339879,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43319190/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15339879"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15339879"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15339879; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15339879]").text(description); $(".js-view-count[data-work-id=15339879]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15339879; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15339879']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15339879, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "23eb534c18d9988eb5451ff27d187a2a" } } $('.js-work-strip[data-work-id=15339879]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15339879,"title":"伪-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-魏B and Hsp70 protein modulation in vitro, and tumor reduction in vivo","translated_title":"","metadata":{"abstract":"Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. 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data-work-id="15339878"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15339878/Involvement_of_NF_%CE%BAB_and_HSP70_signaling_pathways_in_the_apoptosis_of_MDA_MB_231_cells_induced_by_a_prenylated_xanthone_compound_%CE%B1_mangostin_from_Cratoxylum_arborescens"><img alt="Research paper thumbnail of Involvement of NF-魏B and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, 伪-mangostin, from Cratoxylum arborescens" class="work-thumbnail" src="https://attachments.academia-assets.com/43319181/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15339878/Involvement_of_NF_%CE%BAB_and_HSP70_signaling_pathways_in_the_apoptosis_of_MDA_MB_231_cells_induced_by_a_prenylated_xanthone_compound_%CE%B1_mangostin_from_Cratoxylum_arborescens">Involvement of NF-魏B and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, 伪-mangostin, from Cratoxylum arborescens</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NajihahHashim10">Najihah Hashim</a></span></div><div class="wp-workCard_item"><span>Drug design, development and therapy</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailme...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailments. 伪-Mangostin (AM) was isolated from C. arborescens and its cell death mechanism was investigated. AM-induced cytotoxicity was observed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Acridine orange/propidium iodide staining and annexin V were used to detect cells in early phases of apoptosis. High-content screening was used to observe the nuclear condensation, cell permeability, mitochondrial membrane potential, and cytochrome c release. The role of caspases-3/7, -8, and -9, reactive oxygen species, Bcl-2 and Bax expression, and cell cycle arrest were also investigated. To determine the role of the central apoptosis-related proteins, a protein array followed by immunoblot analysis was conducted. Moreover, the involvement of nuclear factor-kappa B (NF-魏B) was also analyzed. Apoptosis was confirmed by the apoptotic cells stained with annexin V and in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e653b41a06dab0343ffe429100bec9e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43319181,"asset_id":15339878,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43319181/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15339878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15339878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15339878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15339878]").text(description); $(".js-view-count[data-work-id=15339878]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15339878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15339878']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15339878, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e653b41a06dab0343ffe429100bec9e4" } } $('.js-work-strip[data-work-id=15339878]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15339878,"title":"Involvement of NF-魏B and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, 伪-mangostin, from Cratoxylum arborescens","translated_title":"","metadata":{"abstract":"Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailments. 伪-Mangostin (AM) was isolated from C. arborescens and its cell death mechanism was investigated. AM-induced cytotoxicity was observed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Acridine orange/propidium iodide staining and annexin V were used to detect cells in early phases of apoptosis. High-content screening was used to observe the nuclear condensation, cell permeability, mitochondrial membrane potential, and cytochrome c release. The role of caspases-3/7, -8, and -9, reactive oxygen species, Bcl-2 and Bax expression, and cell cycle arrest were also investigated. To determine the role of the central apoptosis-related proteins, a protein array followed by immunoblot analysis was conducted. Moreover, the involvement of nuclear factor-kappa B (NF-魏B) was also analyzed. 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profile--work_container" data-work-id="15339877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15339877/Thymoquinone_Inhibits_Murine_Leukemia_WEHI_3_Cells_In_Vivo_and_In_Vitro"><img alt="Research paper thumbnail of Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/43319231/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15339877/Thymoquinone_Inhibits_Murine_Leukemia_WEHI_3_Cells_In_Vivo_and_In_Vitro">Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://malaya.academia.edu/PouyaHassandarvish">Pouya Hassandarvish</a></span></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="48c9c361d76d816dd78574c95a641222" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43319231,"asset_id":15339877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43319231/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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This study aimed to evaluate the in vitro and in vivo anti-leukemic effects of thymoquinone on WEHI-3 cells. Methodology/Principal Findings: The cytotoxic effect of thymoquinone was assessed using an MTT assay, while the inhibitory effect of thymoquinone on murine WEHI-3 cell growth was due to the induction of apoptosis, as evidenced by chromatin condensation dye, Hoechst 33342 and acridine orange/propidium iodide fluorescent staining. In addition, Annexin V staining for early apoptosis was performed using flowcytometric analysis. Apoptosis was found to be associated with the cell cycle arrest at the S phase. Expression of Bax, Bcl2 and HSP 70 proteins were observed by western blotting. The effects of thymoquinone on BALB/ c mice injected with WEHI-3 cells were indicated by the decrease in the body, spleen and liver weights of the animal, as compared to the control. Conclusion: Thymoquinone promoted natural killer cell activities. This compound showed high toxicity against WEHI-3 cell line which was confirmed by an increase of the early apoptosis, followed by up-regulation of the anti-apoptotic protein, Bcl2, and down-regulation of the apoptotic protein, Bax. On the other hand, high reduction of the spleen and liver weight, and significant histopathology study of spleen and liver confirmed that thymoquinone inhibited WEHI-3 growth in the OPEN ACCESS","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"PLoS ONE","grobid_abstract_attachment_id":43319231},"translated_abstract":null,"internal_url":"https://www.academia.edu/15339877/Thymoquinone_Inhibits_Murine_Leukemia_WEHI_3_Cells_In_Vivo_and_In_Vitro","translated_internal_url":"","created_at":"2015-09-01T23:48:29.989-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":34459209,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":5358659,"work_id":15339877,"tagging_user_id":34459209,"tagged_user_id":19314028,"co_author_invite_id":null,"email":"m***n@gmail.com","display_order":0,"name":"Mohamed Ibrahim","title":"Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15437520"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15437520/Acute_Toxicity_and_Gastroprotective_Effect_of_the_Schiff_Base_Ligand_1H_Indole_3_ethylene_5_nitrosalicylaldimine_and_Its_Nickel_II_Complex_on_Ethanol_Induced_Gastric_Lesions_in_Rats"><img alt="Research paper thumbnail of Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15437520/Acute_Toxicity_and_Gastroprotective_Effect_of_the_Schiff_Base_Ligand_1H_Indole_3_ethylene_5_nitrosalicylaldimine_and_Its_Nickel_II_Complex_on_Ethanol_Induced_Gastric_Lesions_in_Rats">Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://malaya.academia.edu/PouyaHassandarvish">Pouya Hassandarvish</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IMustafa2">I. Mustafa</a></span></div><div class="wp-workCard_item"><span>Molecules</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4189e790e67c2c20f3c5cb45e1adab6b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43198249,"asset_id":15437520,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43198249/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15437520"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15437520"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15437520; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15437520]").text(description); $(".js-view-count[data-work-id=15437520]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15437520; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15437520']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15437520, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4189e790e67c2c20f3c5cb45e1adab6b" } } $('.js-work-strip[data-work-id=15437520]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15437520,"title":"Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats","translated_title":"","metadata":{"grobid_abstract":"The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats. Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and its nickel complex. Histological studies of the gastric wall of ulcer control group revealed severe damage of gastric mucosa, along with edema and leucocytes infiltration of the submucosal layer compared to rats pre-treated with either cimetidine or TNS and its nickel (II) compound, where there was marked gastric protection along with reduction of edema and leucocytes infiltration of the submucosal layer. Acute toxicity study done on mice with a higher dose of 5 g/kg of TNS and its nickel (II) complex did not manifest any toxicological signs. 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RSSI-based techniques have been the preferred method for GSM localization on the handset as RSSI information is available in all cell phones. Although the GSM standard allows for a cell phone to receive signal strength information from up to seven cell towers, many of today's cell phones are low-end phones, with limited API support, that gives only information about the associated cell tower. In addition, in many places in the world, the density of cell towers is very small and therefore, the available cell tower information for localization is very limited. This raises the challenge of accurately determining the cell phone location with very limited information, mainly the RSSI of the associated cell tower. In this paper we propose a Hidden Markov Model based solution that leverages the signal strength history from only the associated cell tower to achieve accurate GSM localization. We discuss the challenges of implementing our system and present the details of our system and how it addresses the challenges. To evaluate our proposed system, we implemented it on Androidbased phones. Results for two different testbeds, representing urban and rural environments, show that our system provides at least 156% enhancement in median error in rural areas and at least 68% enhancement in median error in urban areas compared to current RSSI-based GSM localization systems.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"2011 IEEE International Conference on Communications 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extraction and identification of gelatin" class="work-thumbnail" src="https://attachments.academia-assets.com/46501012/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26174861/extraction_and_identification_of_gelatin">extraction and identification of gelatin</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://kau.academia.edu/BasitMariod">Basit Mariod</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39730b001aacc0cdff6d47af24534d27" class="wp-workCard--action" 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{ var workId = 26174861; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26174861]").text(description); $(".js-view-count[data-work-id=26174861]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26174861; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26174861']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26174861, container: "", }); 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Agonoscelis pubescens (sorghum bug) were studied. The two insects showed 27.0 and 28.2% crude protein, respectively. Extraction of gelatin using hot water gave high yield followed by mild acid and distilled water extraction, respectively. SDS-PAGE pattern showed low molecular weight chains, and the two gelatins contained protein with molecular weight of 40 kDa as main component. The differential scanning calorimetry thermograms results confirm no difference between extraction methods concerning the extracted gelatin quality. FTIR spectra of melon and sorghum bug gelatins were similar and the absorption bands were situated in more than 6 bands in melon bug gelatin and only 6 bands in sorghum bug gelatin. Amide II bands of gelatins from both melon and sorghum bug appeared at around 1554 cm -1 , while Amide I bands (1734-1632 cm -1 ) appeared only in melon bug method 2 (MB2) and melon bug method3 (MB3). Microstructures of the insect gelatin examined with the scanning electron microscope showed that melon bug exhibited the finest gelatin network with very small voids. 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15339879"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15339879/%CE%B1_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_%CE%BAB_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo"><img alt="Research paper thumbnail of 伪-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-魏B and Hsp70 protein modulation in vitro, and tumor reduction in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/43319190/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15339879/%CE%B1_Mangostin_from_Cratoxylum_arborescens_demonstrates_apoptogenesis_in_MCF_7_with_regulation_of_NF_%CE%BAB_and_Hsp70_protein_modulation_in_vitro_and_tumor_reduction_in_vivo">伪-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-魏B and Hsp70 protein modulation in vitro, and tumor reduction in vivo</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NajihahHashim10">Najihah Hashim</a></span></div><div class="wp-workCard_item"><span>Drug design, development and therapy</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. In the current ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. In the current study, 伪-Mangostin (AM) was isolated and its cell death mechanism was studied. HCS was undertaken to detect the nuclear condensation, mitochondrial membrane potential, cell permeability, and the release of cytochrome c. An investigation for reactive oxygen species formation was conducted using fluorescent analysis. To determine the mechanism of cell death, human apoptosis proteome profiler assay was conducted. In addition, using immunofluorescence and immunoblotting, the levels of Bcl-2-associated X protein (Bax) and B-cell lymphoma (Bcl)-2 proteins were also tested. Caspaces such as 3/7, 8, and 9 were assessed during treatment. Using HCS and Western blot, the contribution of nuclear factor kappa-B (NF-魏B) was investigated. AM had showed a selective cytotoxicity toward the cancer cells with no toxicity toward the normal cells even at 30 渭g/mL, thereby indicating that AM has the attribute...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23eb534c18d9988eb5451ff27d187a2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43319190,"asset_id":15339879,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43319190/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15339879"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15339879"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15339879; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15339879]").text(description); $(".js-view-count[data-work-id=15339879]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15339879; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15339879']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15339879, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "23eb534c18d9988eb5451ff27d187a2a" } } $('.js-work-strip[data-work-id=15339879]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15339879,"title":"伪-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-魏B and Hsp70 protein modulation in vitro, and tumor reduction in vivo","translated_title":"","metadata":{"abstract":"Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. 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data-work-id="15339878"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15339878/Involvement_of_NF_%CE%BAB_and_HSP70_signaling_pathways_in_the_apoptosis_of_MDA_MB_231_cells_induced_by_a_prenylated_xanthone_compound_%CE%B1_mangostin_from_Cratoxylum_arborescens"><img alt="Research paper thumbnail of Involvement of NF-魏B and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, 伪-mangostin, from Cratoxylum arborescens" class="work-thumbnail" src="https://attachments.academia-assets.com/43319181/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15339878/Involvement_of_NF_%CE%BAB_and_HSP70_signaling_pathways_in_the_apoptosis_of_MDA_MB_231_cells_induced_by_a_prenylated_xanthone_compound_%CE%B1_mangostin_from_Cratoxylum_arborescens">Involvement of NF-魏B and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, 伪-mangostin, from Cratoxylum arborescens</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NajihahHashim10">Najihah Hashim</a></span></div><div class="wp-workCard_item"><span>Drug design, development and therapy</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailme...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailments. 伪-Mangostin (AM) was isolated from C. arborescens and its cell death mechanism was investigated. AM-induced cytotoxicity was observed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Acridine orange/propidium iodide staining and annexin V were used to detect cells in early phases of apoptosis. High-content screening was used to observe the nuclear condensation, cell permeability, mitochondrial membrane potential, and cytochrome c release. The role of caspases-3/7, -8, and -9, reactive oxygen species, Bcl-2 and Bax expression, and cell cycle arrest were also investigated. To determine the role of the central apoptosis-related proteins, a protein array followed by immunoblot analysis was conducted. Moreover, the involvement of nuclear factor-kappa B (NF-魏B) was also analyzed. Apoptosis was confirmed by the apoptotic cells stained with annexin V and in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e653b41a06dab0343ffe429100bec9e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43319181,"asset_id":15339878,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43319181/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15339878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15339878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15339878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15339878]").text(description); $(".js-view-count[data-work-id=15339878]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15339878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15339878']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15339878, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e653b41a06dab0343ffe429100bec9e4" } } $('.js-work-strip[data-work-id=15339878]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15339878,"title":"Involvement of NF-魏B and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, 伪-mangostin, from Cratoxylum arborescens","translated_title":"","metadata":{"abstract":"Cratoxylum arborescens has been used traditionally in Malaysia for the treatment of various ailments. 伪-Mangostin (AM) was isolated from C. arborescens and its cell death mechanism was investigated. AM-induced cytotoxicity was observed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Acridine orange/propidium iodide staining and annexin V were used to detect cells in early phases of apoptosis. High-content screening was used to observe the nuclear condensation, cell permeability, mitochondrial membrane potential, and cytochrome c release. The role of caspases-3/7, -8, and -9, reactive oxygen species, Bcl-2 and Bax expression, and cell cycle arrest were also investigated. To determine the role of the central apoptosis-related proteins, a protein array followed by immunoblot analysis was conducted. Moreover, the involvement of nuclear factor-kappa B (NF-魏B) was also analyzed. 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profile--work_container" data-work-id="15339877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15339877/Thymoquinone_Inhibits_Murine_Leukemia_WEHI_3_Cells_In_Vivo_and_In_Vitro"><img alt="Research paper thumbnail of Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro" class="work-thumbnail" src="https://attachments.academia-assets.com/43319231/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15339877/Thymoquinone_Inhibits_Murine_Leukemia_WEHI_3_Cells_In_Vivo_and_In_Vitro">Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FirouzehDehghan">Firouzeh Dehghan</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://malaya.academia.edu/PouyaHassandarvish">Pouya Hassandarvish</a></span></div><div class="wp-workCard_item"><span>PLoS ONE</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="48c9c361d76d816dd78574c95a641222" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43319231,"asset_id":15339877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43319231/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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This study aimed to evaluate the in vitro and in vivo anti-leukemic effects of thymoquinone on WEHI-3 cells. Methodology/Principal Findings: The cytotoxic effect of thymoquinone was assessed using an MTT assay, while the inhibitory effect of thymoquinone on murine WEHI-3 cell growth was due to the induction of apoptosis, as evidenced by chromatin condensation dye, Hoechst 33342 and acridine orange/propidium iodide fluorescent staining. In addition, Annexin V staining for early apoptosis was performed using flowcytometric analysis. Apoptosis was found to be associated with the cell cycle arrest at the S phase. Expression of Bax, Bcl2 and HSP 70 proteins were observed by western blotting. The effects of thymoquinone on BALB/ c mice injected with WEHI-3 cells were indicated by the decrease in the body, spleen and liver weights of the animal, as compared to the control. Conclusion: Thymoquinone promoted natural killer cell activities. This compound showed high toxicity against WEHI-3 cell line which was confirmed by an increase of the early apoptosis, followed by up-regulation of the anti-apoptotic protein, Bcl2, and down-regulation of the apoptotic protein, Bax. On the other hand, high reduction of the spleen and liver weight, and significant histopathology study of spleen and liver confirmed that thymoquinone inhibited WEHI-3 growth in the OPEN ACCESS","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"PLoS ONE","grobid_abstract_attachment_id":43319231},"translated_abstract":null,"internal_url":"https://www.academia.edu/15339877/Thymoquinone_Inhibits_Murine_Leukemia_WEHI_3_Cells_In_Vivo_and_In_Vitro","translated_internal_url":"","created_at":"2015-09-01T23:48:29.989-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":34459209,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":5358659,"work_id":15339877,"tagging_user_id":34459209,"tagged_user_id":19314028,"co_author_invite_id":null,"email":"m***n@gmail.com","display_order":0,"name":"Mohamed Ibrahim","title":"Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="15437520"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/15437520/Acute_Toxicity_and_Gastroprotective_Effect_of_the_Schiff_Base_Ligand_1H_Indole_3_ethylene_5_nitrosalicylaldimine_and_Its_Nickel_II_Complex_on_Ethanol_Induced_Gastric_Lesions_in_Rats"><img alt="Research paper thumbnail of Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/15437520/Acute_Toxicity_and_Gastroprotective_Effect_of_the_Schiff_Base_Ligand_1H_Indole_3_ethylene_5_nitrosalicylaldimine_and_Its_Nickel_II_Complex_on_Ethanol_Induced_Gastric_Lesions_in_Rats">Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://malaya.academia.edu/PouyaHassandarvish">Pouya Hassandarvish</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://cardiff.academia.edu/MohamedIbrahim">Mohamed Ibrahim</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IMustafa2">I. Mustafa</a></span></div><div class="wp-workCard_item"><span>Molecules</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4189e790e67c2c20f3c5cb45e1adab6b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43198249,"asset_id":15437520,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43198249/download_file?st=MTczMjM5MzkwNiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="15437520"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="15437520"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15437520; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15437520]").text(description); $(".js-view-count[data-work-id=15437520]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15437520; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='15437520']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 15437520, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4189e790e67c2c20f3c5cb45e1adab6b" } } $('.js-work-strip[data-work-id=15437520]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":15437520,"title":"Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats","translated_title":"","metadata":{"grobid_abstract":"The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats. Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and its nickel complex. Histological studies of the gastric wall of ulcer control group revealed severe damage of gastric mucosa, along with edema and leucocytes infiltration of the submucosal layer compared to rats pre-treated with either cimetidine or TNS and its nickel (II) compound, where there was marked gastric protection along with reduction of edema and leucocytes infiltration of the submucosal layer. Acute toxicity study done on mice with a higher dose of 5 g/kg of TNS and its nickel (II) complex did not manifest any toxicological signs. 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RSSI-based techniques have been the preferred method for GSM localization on the handset as RSSI information is available in all cell phones. Although the GSM standard allows for a cell phone to receive signal strength information from up to seven cell towers, many of today's cell phones are low-end phones, with limited API support, that gives only information about the associated cell tower. In addition, in many places in the world, the density of cell towers is very small and therefore, the available cell tower information for localization is very limited. This raises the challenge of accurately determining the cell phone location with very limited information, mainly the RSSI of the associated cell tower. In this paper we propose a Hidden Markov Model based solution that leverages the signal strength history from only the associated cell tower to achieve accurate GSM localization. We discuss the challenges of implementing our system and present the details of our system and how it addresses the challenges. To evaluate our proposed system, we implemented it on Androidbased phones. Results for two different testbeds, representing urban and rural environments, show that our system provides at least 156% enhancement in median error in rural areas and at least 68% enhancement in median error in urban areas compared to current RSSI-based GSM localization systems.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"2011 IEEE International Conference on Communications 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