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Collegiate Inventors Competition </li> </ol> </div> </div> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-mit-page-title"> <div class="block-inner"> <h1><span itemprop="name headline">Linzixuan (Rhoda) Zhang wins 2024 Collegiate Inventors Competition</span> </span> </h1> </div> </div> <div id="block-mit-content"> <div class="block-inner"> <article> <div> <div itemprop="description" class="news-article--dek"> <span>MIT graduate student earns top honors in Graduate and People’s Choice categories for her work on nutrient-stabilizing materials.</span> </div> <div class="news-article--indicators"> </div> <div itemprop="author" class="news-article--authored-by"> <span class="news-article--author">Nina Tamburello</span> <span class="news-article--authored-by--separator">|</span> <span class="news-article--source">Koch Institute</span> </div> <div itemprop="datePublished" class="news-article--publication-date"> <div class="visually-hidden"> <span class="label">Publication Date</span><span class="visually-hidden">:</span> </div> <time datetime="2024-11-14T21:30:00Z">November 14, 2024</time> </div> <div data-nosnippet="true" class="news-article--press-inquiries"> <div class="news-article--press-inquiries--header"><a href="#press-inquiries" class="news-article--press-inquiries--title--link"><span class="arrow down"></span><svg class="icon--info" xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 20 20"> <path id="iconfinder_icon-information_2867914" d="M12,22A10,10,0,1,1,22,12,10,10,0,0,1,12,22Zm0-2a8,8,0,1,0-8-8A8,8,0,0,0,12,20Zm0-9a1,1,0,0,1,1,1v4a1,1,0,0,1-2,0V12A1,1,0,0,1,12,11Zm0-4a1,1,0,1,1-1,1A1,1,0,0,1,12,7Z" transform="translate(-2 -2)" fill="currentColor"/> </svg> <span class="link-text">Press Inquiries</span></a></div> <div id="press-inquiries" class="news-article--press-inquiries--descr"> <div class="news-article--press-inquiries--press-contacts"> <h3 > <span class="label">Press Contact</span><span class="visually-hidden">:</span> </h3> <div class="press-contact"> <div class="news-article--press-inquiries--press-contact--name"> Bendta Schroeder </div> <div class="news-article--press-inquiries--press-contact--email"> <span class="label"> Email: </span> <a href="mailto:bendta@mit.edu">bendta@mit.edu</a> </div> <div class="news-article--press-inquiries--press-contact--phone"> <span class="label"> Phone: </span> 617-324-7795 </div> <div class="news-article--press-inquiries--press-contact--org"> Koch Institute </div> </div> </div> <div class="news-article--press-inquiries--descr--close--container"> <a href="#" class="news-article--press-inquiries--descr--close--button-link"><span class="news-article--press-inquiries--descr--close--button-icon"><svg class="icon--button--close" xmlns="http://www.w3.org/2000/svg" width="22" height="22" viewBox="0 0 22 22"> <g transform="translate(-32 -33)"> <path id="Path_2543" data-name="Path 2543" d="M43,33A11,11,0,1,0,54,44,11,11,0,0,0,43,33Zm5.318,14.708a.386.386,0,0,1,.113.275.378.378,0,0,1-.113.275l-1.061,1.066a.382.382,0,0,1-.275.113.4.4,0,0,1-.275-.113L43,45.611l-3.7,3.717a.375.375,0,0,1-.275.113.4.4,0,0,1-.275-.113l-1.061-1.066a.386.386,0,0,1-.113-.275.378.378,0,0,1,.113-.275L41.4,43.98,37.677,40.3a.394.394,0,0,1,0-.555l1.061-1.066a.391.391,0,0,1,.55,0L43,42.345l3.717-3.668a.391.391,0,0,1,.55,0l1.061,1.066a.394.394,0,0,1,0,.555L44.606,43.98Z" fill="currentColor"/> </g> </svg> </span> Close</a> </div> </div> </div> <div class="news-article--full-width-wrapper"> <div class="news-article--full-width-wrapper-inner"> <div class="news-article--images-gallery--wrapper"> <div class="news-article--images-gallery"> <div class="news-article--image-item"> <div class="news-article--media--image--file"> <img loading="lazy" src="/themes/mit/src/img/placeholder/placeholder--news-article--image-gallery.jpg" width="900" height="600" alt=" Ana Jaklenec, Robert Langer, Linzixuan (Rhoda) Zhang, and Xin Yang stand in front of a wall of framed awards. Zhang wears a medal ribbon around her neck and, together with Langer, holds a framed certificate. " class="ondemand" data-src="/sites/default/files/styles/news_article__image_gallery/public/images/202411/MIT-KI-Collegiate-Inventors-Zhang.jpg?itok=TSnYl7Pa" /> </div> <div class="news-article--media--image--descr--wrapper"> <div class="news-article--media--image--descr"> <div class="news-article--media--image--caption"> <div class="visually-hidden"> <span class="label">Caption</span><span class="visually-hidden">:</span> </div> Left to right: Koch Institute Principal Investigator Ana Jaklenec, David H. Koch (1962) Institute Professor Robert Langer, doctoral candidate Linzixuan (Rhoda) Zhang, and postdoc Xin Yang. </div> <div class="news-article--media--image--credits"> <div class="visually-hidden"> <span class="label">Credits</span><span class="visually-hidden">:</span> </div> Photo courtesy of the Jaklenec Group. </div> </div> </div> </div> </div> <div class="news-article--images-gallery--nav"> <p class="news-article--images-gallery--nav--inner"> <button class="news-article--images-gallery--nav--button news-article--images-gallery--nav--button--previous"><svg class="arrow--point-west--slider" data-name="Group 2041" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="0" viewBox="0 0 16.621 30.183"> <defs> <clipPath id="clip-path"> <path id="Path_494" data-name="Path 494" d="M0-126.293H16.621V-96.11H0Z" transform="translate(0 126.293)" /> </clipPath> </defs> <g id="Group_112" data-name="Group 112" clip-path="url(#clip-path)"> <g id="Group_111" data-name="Group 111" transform="translate(0 0)"> <path id="Path_493" data-name="Path 493" d="M-48.055-96.11a1.522,1.522,0,0,1-1.081-.448L-62.7-110.12a1.529,1.529,0,0,1,0-2.163l13.562-13.562a1.528,1.528,0,0,1,2.162,0,1.529,1.529,0,0,1,0,2.163L-59.454-111.2l12.48,12.48a1.529,1.529,0,0,1,0,2.163,1.524,1.524,0,0,1-1.081.448" transform="translate(63.146 126.293)" /> </g> </g> </svg> <span class="visually-hidden">Previous image</span></button> <button class="news-article--images-gallery--nav--button news-article--images-gallery--nav--button--next"><span class="visually-hidden">Next image</span><svg class="arrow--point-east--slider" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="0" viewBox="0 0 16.621 30.183"> <defs> <clipPath id="clip-path"> <path id="Path_496" data-name="Path 496" d="M0-126.293H16.621V-96.11H0Z" transform="translate(0 126.293)"/> </clipPath> </defs> <g id="Group_2042" data-name="Group 2042" transform="translate(16.621 30.183) rotate(180)"> <g id="Group_115" data-name="Group 115" clip-path="url(#clip-path)"> <g id="Group_114" data-name="Group 114" transform="translate(0 0)"> <path id="Path_495" data-name="Path 495" d="M-48.055-96.11a1.522,1.522,0,0,1-1.081-.448L-62.7-110.12a1.529,1.529,0,0,1,0-2.163l13.562-13.562a1.528,1.528,0,0,1,2.162,0,1.529,1.529,0,0,1,0,2.163L-59.454-111.2l12.48,12.48a1.529,1.529,0,0,1,0,2.163,1.524,1.524,0,0,1-1.081.448" transform="translate(63.146 126.293)" /> </g> </g> </g> </svg></button> </p> </div> </div> </div> </div> <div class="news-article--content"> <div class="news-article--content--body" itemprop="articleBody"> <div class="news-article--content--body--inner"> <div class="paragraph paragraph--type--content-block-text paragraph--view-mode--default"> <div><p paraid="2120210298" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{87}">Linzixuan (Rhoda) Zhang, a doctoral candidate in the MIT Department of Chemical Engineering, recently won the 2024 <a href="https://www.invent.org/collegiate-inventors">Collegiate Inventors Competition</a>, medaling in both the Graduate and People’s Choice categories for developing materials to stabilize nutrients in food with the goal of improving global health.  </p></div><div><p paraid="2073467639" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{103}">The annual competition, organized by the National Inventors Hall of Fame and United States Patent and Trademark Office (USPTO), celebrates college and university student inventors. The finalists present their inventions to a panel of final-round judges composed of National Inventors Hall of Fame inductees and USPTO officials. </p></div><div><p paraid="90185418" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{123}">No stranger to having her work in the limelight, Zhang is a three-time winner of the Koch Institute Image Awards in <a href="https://ki-images.mit.edu/2022/zhang-5" target="_blank" rel="noreferrer noopener">2022</a>, <a href="https://ki-images.mit.edu/2023/zhang-han-4" target="_blank" rel="noreferrer noopener">2023</a>, and <a href="https://ki-images.mit.edu/2024/han-3" target="_blank" rel="noreferrer noopener">2024</a>, as well as a <a href="https://news.mit.edu/2022/phd-students-shed-light-important-water-food-research-1110" target="_blank" rel="noreferrer noopener">2022 fellow</a> at the MIT Abdul Latif Jameel Water and Food Systems Lab.  </p></div><div><p paraid="1765451387" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{161}">"Rhoda is an exceptionally dedicated and creative student. Her well-deserved award recognizes the potential of her research on nutrient stabilization, which could have a significant impact on society," says Ana Jaklenec, one of Zhang’s advisors and a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. Zhang is also advised by David H. Koch (1962) Institute Professor Robert Langer. </p></div><div><p><strong>Frameworks for global health</strong></p></div><div><p paraid="1703608833" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{181}">In a world where nearly 2 billion people suffer from micronutrient deficiencies, particularly iron, the urgency for effective solutions has never been greater. Iron deficiency is especially harmful for vulnerable populations such as children and pregnant women, since it can lead to weakened immune systems and developmental delays. </p></div><div><p paraid="551083007" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{187}">The World Health Organization has highlighted food fortification as a cost-effective strategy, yet many current methods fall short. Iron and other nutrients can break down during processing or cooking, and synthetic additives often come with high costs and environmental drawbacks. </p></div><div><p paraid="981242941" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{193}">Zhang, along with her teammate, Xin Yang, a postdoc associate at Koch Institute, set out to innovate new technologies for nutrient fortification that are effective, accessible, and sustainable, leading to the invention nutritional metal-organic frameworks (NuMOFs) and the subsequent launch of MOFe Coffee, the world’s first iron-fortified coffee. NuMOFs not only protect essential nutrients such as iron while in food for long periods of time, but also make them more easily absorbed and used once consumed.</p></div><div><p paraid="1481617508" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{215}">The inspiration for the coffee came from the success of iodized salt, which significantly reduced iodine deficiency worldwide. Because coffee and tea are associated with low iron absorption, iron fortification would directly address the challenge.</p></div><div><p paraid="70175249" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{225}">However, replicating the success of iodized salt for iron fortification has been extremely challenging due to the micronutrient’s high reactivity and the instability of iron(II) salts. As researchers with backgrounds in material science, chemistry, and food technology, Zhang and Yang leveraged their expertise to develop a solution that could overcome these technical barriers. </p></div><div><p paraid="302688914" paraeid="{d990ab78-4f66-4063-b7eb-179bad887d6f}{251}">The fortified coffee serves as a practical example of how NuMOFs can help people increase their iron intake by engaging in a habit that’s already part of their daily routine, with significant potential benefits for women, who are disproportionately affected by iron deficiency. The team plans to expand the technology to incorporate additional nutrients to address a wider array of nutritional deficiencies and improve health equity globally.</p></div><div><p><strong>Fast-track to addressing global health improvements</strong></p></div><div><p paraid="2061106427" paraeid="{8e32e0dd-a7a0-46d8-a802-0c3ebab7a1f0}{12}">Looking ahead, Zhang and Yang in the Jaklenec Group are focused on both product commercialization and ongoing research, refining MOFe Coffee to enhance nutrient stability and ensuring the product remains palatable while maximizing iron absorption.</p></div><div><p paraid="399188990" paraeid="{8e32e0dd-a7a0-46d8-a802-0c3ebab7a1f0}{26}">Winning the CIC competition means that Zhang, Yang, and the team can fast-track their patent application with the USPTO. The team hopes that their fast-tracked patent will allow them to attract more potential investors and partners, which is crucial for scaling their efforts. A quicker patent process also means that the team can bring the technology to market faster, helping improve global nutrition and health for those who need it most. </p></div><div><p paraid="1731237381" paraeid="{8e32e0dd-a7a0-46d8-a802-0c3ebab7a1f0}{32}">“Our goal is to make a real difference in addressing micronutrient deficiencies around the world,” says Zhang.  </p></div> </div> </div> </div> <div class="news-article--content--side-column"> <div> <div class="block-inner"> <div class="news-article--share"> <div class="news-article--share--inner"> <h3 class="news-article--share--title">Share<span class="visually-hidden"> this news article on:</span></h3> <ul class="news-article--share--list-items"> <li class="news-article--share--item"> <a class="news-article--share--link" href="https://twitter.com/share?url=https://news.mit.edu/2024/linzixuan-rhoda-zhang-wins-collegiate-inventors-competition-1114" target="_blank"> <svg class="news-article--share--link--icon 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