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vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Distribution"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Distribution</span> </div> </a> <ul id="toc-Distribution-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-AChE_gene" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#AChE_gene"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>AChE gene</span> </div> </a> <button aria-controls="toc-AChE_gene-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle AChE gene subsection</span> </button> <ul id="toc-AChE_gene-sublist" class="vector-toc-list"> <li id="toc-AChET" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#AChET"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>AChE<sub>T</sub></span> </div> </a> <ul id="toc-AChET-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-AChEH" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#AChEH"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>AChE<sub>H</sub></span> </div> </a> <ul id="toc-AChEH-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-AChER" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#AChER"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>AChE<sub>R</sub></span> </div> </a> <ul id="toc-AChER-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Nomenclature" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Nomenclature"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Nomenclature</span> </div> </a> <ul id="toc-Nomenclature-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Inhibitors" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Inhibitors"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Inhibitors</span> </div> </a> <ul id="toc-Inhibitors-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">12</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Acetylcholinesterase</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 32 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-32" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">32 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D8%B3%D8%AA%D9%8A%D8%B1%D8%A7%D8%B2_%D8%A7%D9%84%D8%A3%D8%B3%D9%8A%D8%AA%D9%8A%D9%84_%D9%83%D9%88%D9%84%D9%8A%D9%86" title="إستيراز الأسيتيل كولين – Arabic" lang="ar" hreflang="ar" data-title="إستيراز الأسيتيل كولين" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%90%D1%86%D0%B5%D1%82%D0%B8%D0%BB%D1%85%D0%BE%D0%BB%D0%B8%D0%BD%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="Ацетилхолинестераза – Bulgarian" lang="bg" hreflang="bg" data-title="Ацетилхолинестераза" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bo mw-list-item"><a href="https://bo.wikipedia.org/wiki/%E0%BD%A8%E0%BD%BA%E0%BC%8B%E0%BD%A6%E0%BD%B2%E0%BC%8B%E0%BD%8A%E0%BD%B2%E0%BD%A3%E0%BC%8B%E0%BD%81%E0%BD%BC%E0%BC%8B%E0%BD%A3%E0%BD%B2%E0%BC%8B%E0%BD%93%E0%BD%BA%E0%BC%8B%E0%BD%A6%E0%BD%B2%E0%BC%8B%E0%BD%8A%E0%BD%BA%E0%BC%8B%E0%BD%A2%E0%BD%BA%E0%BC%8B%E0%BD%A6%E0%BD%B2%E0%BC%8B%E0%BD%A6%E0%BE%A8%E0%BD%B2%E0%BD%93%E0%BC%8B%E0%BD%A2%E0%BE%AB%E0%BD%A6%E0%BC%8D" title="ཨེ་སི་ཊིལ་ཁོ་ལི་ནེ་སི་ཊེ་རེ་སི་སྨིན་རྫས། – Tibetan" lang="bo" hreflang="bo" data-title="ཨེ་སི་ཊིལ་ཁོ་ལི་ནེ་སི་ཊེ་རེ་སི་སྨིན་རྫས།" data-language-autonym="བོད་ཡིག" data-language-local-name="Tibetan" class="interlanguage-link-target"><span>བོད་ཡིག</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Acetilholinesteraza" title="Acetilholinesteraza – Bosnian" lang="bs" hreflang="bs" data-title="Acetilholinesteraza" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Acetilcolinesterasa" title="Acetilcolinesterasa – Catalan" lang="ca" hreflang="ca" data-title="Acetilcolinesterasa" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Acetylcholinester%C3%A1za" title="Acetylcholinesteráza – Czech" lang="cs" hreflang="cs" data-title="Acetylcholinesteráza" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/ACHE" title="ACHE – Welsh" lang="cy" hreflang="cy" data-title="ACHE" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Acetylcholinesterase" title="Acetylcholinesterase – Danish" lang="da" hreflang="da" data-title="Acetylcholinesterase" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Acetylcholinesterase" title="Acetylcholinesterase – German" lang="de" hreflang="de" data-title="Acetylcholinesterase" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Acetilcolinesterasa" title="Acetilcolinesterasa – Spanish" lang="es" hreflang="es" data-title="Acetilcolinesterasa" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Azetilkolinesterasa" title="Azetilkolinesterasa – Basque" lang="eu" hreflang="eu" data-title="Azetilkolinesterasa" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%D8%B3%D8%AA%DB%8C%D9%84%E2%80%8C%DA%A9%D9%88%D9%84%DB%8C%D9%86_%D8%A7%D8%B3%D8%AA%D8%B1%D8%A7%D8%B2" title="استیل‌کولین استراز – Persian" lang="fa" hreflang="fa" data-title="استیل‌کولین استراز" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Ac%C3%A9tylcholinest%C3%A9rase" title="Acétylcholinestérase – French" lang="fr" hreflang="fr" data-title="Acétylcholinestérase" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Acetilcolinesterase" title="Acetilcolinesterase – Galician" lang="gl" hreflang="gl" data-title="Acetilcolinesterase" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%95%84%EC%84%B8%ED%8B%B8%EC%BD%9C%EB%A6%B0%EC%97%90%EC%8A%A4%ED%84%B0%EB%A0%88%EC%9D%B4%EC%8A%A4" title="아세틸콜린에스터레이스 – Korean" lang="ko" hreflang="ko" data-title="아세틸콜린에스터레이스" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Acetilcolinesterasi" title="Acetilcolinesterasi – Italian" lang="it" hreflang="it" data-title="Acetilcolinesterasi" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%A6%D7%98%D7%99%D7%9C%D7%9B%D7%95%D7%9C%D7%99%D7%9F_%D7%90%D7%A1%D7%98%D7%A8%D7%90%D7%96" title="אצטילכולין אסטראז – Hebrew" lang="he" hreflang="he" data-title="אצטילכולין אסטראז" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Acetilkolin-%C3%A9szter%C3%A1z" title="Acetilkolin-észteráz – Hungarian" lang="hu" hreflang="hu" data-title="Acetilkolin-észteráz" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Asetilkolinesterase" title="Asetilkolinesterase – Malay" lang="ms" hreflang="ms" data-title="Asetilkolinesterase" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Acetylcholinesterase" title="Acetylcholinesterase – Dutch" lang="nl" hreflang="nl" data-title="Acetylcholinesterase" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Acetylocholinoesteraza" title="Acetylocholinoesteraza – Polish" lang="pl" hreflang="pl" data-title="Acetylocholinoesteraza" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Acetilcolinesteraz%C4%83" title="Acetilcolinesterază – Romanian" lang="ro" hreflang="ro" data-title="Acetilcolinesterază" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D1%86%D0%B5%D1%82%D0%B8%D0%BB%D1%85%D0%BE%D0%BB%D0%B8%D0%BD%D1%8D%D1%81%D1%82%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="Ацетилхолинэстераза – Russian" lang="ru" hreflang="ru" data-title="Ацетилхолинэстераза" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Acetilholin-esteraza" title="Acetilholin-esteraza – Slovenian" lang="sl" hreflang="sl" data-title="Acetilholin-esteraza" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Acetilholinesteraza" title="Acetilholinesteraza – Serbian" lang="sr" hreflang="sr" data-title="Acetilholinesteraza" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Acetilholinesteraza" title="Acetilholinesteraza – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Acetilholinesteraza" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Asetyylikoliiniesteraasi" title="Asetyylikoliiniesteraasi – Finnish" lang="fi" hreflang="fi" data-title="Asetyylikoliiniesteraasi" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Acetylkolinesteras" title="Acetylkolinesteras – Swedish" lang="sv" hreflang="sv" data-title="Acetylkolinesteras" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Asetilkolinesteraz" title="Asetilkolinesteraz – Turkish" lang="tr" hreflang="tr" data-title="Asetilkolinesteraz" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D1%86%D0%B5%D1%82%D0%B8%D0%BB%D1%85%D0%BE%D0%BB%D1%96%D0%BD%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="Ацетилхолінестераза – Ukrainian" lang="uk" hreflang="uk" data-title="Ацетилхолінестераза" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Acetylcholinesterase" title="Acetylcholinesterase – Vietnamese" lang="vi" hreflang="vi" data-title="Acetylcholinesterase" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E4%B9%99%E9%85%B0%E8%83%86%E7%A2%B1%E9%85%AF%E9%85%B6" title="乙酰胆碱酯酶 – Chinese" lang="zh" hreflang="zh" data-title="乙酰胆碱酯酶" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a 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data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">"ACHE" redirects here. For other uses, see <a href="/wiki/Ache_(disambiguation)" class="mw-redirect mw-disambig" title="Ache (disambiguation)">Ache</a>.</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Not to be confused with <a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a> or <a href="/wiki/Choline_acetyltransferase" title="Choline acetyltransferase">Choline acetyltransferase</a>.</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">acetylcholinesterase</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:The_reaction_catalyzed_by_acetylcholinesterase.tif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/The_reaction_catalyzed_by_acetylcholinesterase.tif/lossy-page1-220px-The_reaction_catalyzed_by_acetylcholinesterase.tif.jpg" decoding="async" width="220" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/The_reaction_catalyzed_by_acetylcholinesterase.tif/lossy-page1-330px-The_reaction_catalyzed_by_acetylcholinesterase.tif.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1d/The_reaction_catalyzed_by_acetylcholinesterase.tif/lossy-page1-440px-The_reaction_catalyzed_by_acetylcholinesterase.tif.jpg 2x" data-file-width="2840" data-file-height="306" /></a></span><div class="infobox-caption">Acetylcholinesterase catalyzes the hydrolysis of acetylcholine to acetate ion and choline</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: light-dark(#ddd, #404244) !important; color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC no.</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://www.enzyme-database.org/query.php?ec=3.1.1.7">3.1.1.7</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/CAS_registry_number" class="mw-redirect" title="CAS registry number">CAS no.</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=9000-81-1&title=">9000-81-1 </a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: light-dark(#ddd, #404244) !important; color:inherit;">Databases</th></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/IntEnz" title="IntEnz">IntEnz</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=3.1.1.7">IntEnz view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/BRENDA" title="BRENDA">BRENDA</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.7">BRENDA entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/ExPASy" class="mw-redirect" title="ExPASy">ExPASy</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/3.1.1.7">NiceZyme view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+3.1.1.7">KEGG entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/MetaCyc" title="MetaCyc">MetaCyc</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://biocyc.org/META/substring-search?type=NIL&object=3.1.1.7">metabolic pathway</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/PRIAM_enzyme-specific_profiles" title="PRIAM enzyme-specific profiles">PRIAM</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=3.1.1.7">profile</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> structures</th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:3.1.1.7">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:3.1.1.7">PDBe</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=3.1.1.7">PDBsum</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit;"><a href="/wiki/Gene_Ontology" title="Gene Ontology">Gene Ontology</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003990">AmiGO </a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/term/GO:0003990">QuickGO</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: light-dark(#ddd, #404244) !important; color:inherit;">Search</th></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit; border:light-dark(#f8f9fa, #202122) 2px solid !important; border-width:3px 2px 0 0;"><a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit; border:light-dark(#f8f9fa, #202122) 2px solid !important; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=3.1.1.7%5BEC/RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit; border:light-dark(#f8f9fa, #202122) 2px solid !important; border-width:3px 2px 0 0;"><a href="/wiki/PubMed" title="PubMed">PubMed</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit; border:light-dark(#f8f9fa, #202122) 2px solid !important; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=3.1.1.7%5BEC/RN%20Number%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: light-dark(#e7dcc3, #3b3018) !important; color:inherit; border:light-dark(#f8f9fa, #202122) 2px solid !important; border-width:3px 2px 0 0;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a></th><td class="infobox-data" style="background-color: light-dark(#eee, #27292d) !important; color:inherit; border:light-dark(#f8f9fa, #202122) 2px solid !important; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein?term=3.1.1.7%5BEC/RN%20Number%5D">proteins</a></td></tr></tbody></table></td></tr></tbody></table> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">ACHE</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:PBB_Protein_ACHE_image.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_Protein_ACHE_image.jpg/250px-PBB_Protein_ACHE_image.jpg" decoding="async" width="250" height="250" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_Protein_ACHE_image.jpg/375px-PBB_Protein_ACHE_image.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/0/0e/PBB_Protein_ACHE_image.jpg 2x" data-file-width="500" data-file-height="500" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P21836%20or%20P22303">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P21836,P22303">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4EY7">4EY7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4PQE">4PQE</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1F8U">1F8U</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3LII">3LII</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4BDT">4BDT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4M0E">4M0E</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4M0F">4M0F</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1VZJ">1VZJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2X8B">2X8B</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1B41">1B41</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4EY4">4EY4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4EY5">4EY5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4EY6">4EY6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4EY8">4EY8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FOQ">5FOQ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5HF9">5HF9</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5HF6">5HF6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FPQ">5FPQ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5HF8">5HF8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5HFA">5HFA</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/108">ACHE</a></span>, AChE, acetylhydrolase, acetylcholinesterase (Yt blood group), ACEE, ARN-YT, acetylcholinesterase (Cartwright blood group), true cholinesterase (dated synonym)</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/100740">100740</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:87876">87876</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=543">543</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ACHE">ACHE</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000087085">ACHE - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (human)"><img alt="Chromosome 7 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/300px-Ideogram_human_chromosome_7.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/450px-Ideogram_human_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/99/Ideogram_human_chromosome_7.svg/600px-Ideogram_human_chromosome_7.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_7_(human)" class="mw-redirect" title="Chromosome 7 (human)">Chromosome 7 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_7_ideogram.svg" class="mw-file-description" title="Chromosome 7 (human)"><img alt="Chromosome 7 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/300px-Human_chromosome_7_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/450px-Human_chromosome_7_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b5/Human_chromosome_7_ideogram.svg/600px-Human_chromosome_7_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 180.83704602857px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ACHE"><img alt="Genomic location for ACHE" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 186.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ACHE"><img alt="Genomic location for ACHE" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">7q22.1</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">100,889,994 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">100,896,974 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (mouse)"><img alt="Chromosome 5 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/390px-Ideogram_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/520px-Ideogram_house_mouse_chromosome_5.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 5 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (mouse)"><img alt="Chromosome 5 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/300px-Ideogram_of_house_mouse_chromosome_5.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/450px-Ideogram_of_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/600px-Ideogram_of_house_mouse_chromosome_5.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 260.55588496565px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ACHE"><img alt="Genomic location for ACHE" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 266.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ACHE"><img alt="Genomic location for ACHE" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">5 G2|5 76.32 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">137,285,781 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">137,292,728 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000087085">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">muscle of thigh</li><br /><li style="line-height: 137%;">right hemisphere of cerebellum</li><br /><li style="line-height: 137%;">Hypothalamus</li><br /><li style="line-height: 137%;">gastrocnemius muscle</li><br /><li style="line-height: 137%;">nucleus accumbens</li><br /><li style="line-height: 137%;">triceps brachii muscle</li><br /><li style="line-height: 137%;">Skeletal muscle tissue of rectus abdominis</li><br /><li style="line-height: 137%;">right frontal lobe</li><br /><li style="line-height: 137%;">putamen</li><br /><li style="line-height: 137%;">caudate nucleus</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000023328">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">Medulla Oblongata</li><br /><li style="line-height: 137%;">Pons</li><br /><li style="line-height: 137%;">central gray substance of midbrain</li><br /><li style="line-height: 137%;">bone marrow</li><br /><li style="line-height: 137%;">superior colliculus</li><br /><li style="line-height: 137%;">Hypothalamus</li><br /><li style="line-height: 137%;">cerebellar cortex</li><br /><li style="line-height: 137%;">striatum of neuraxis</li><br /><li style="line-height: 137%;">nucleus of stria terminalis</li><br /><li style="line-height: 137%;">inferior colliculi</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000087085">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ACHE_205377_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PBB_GE_ACHE_205377_s_at_fs.png/250px-PBB_GE_ACHE_205377_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PBB_GE_ACHE_205377_s_at_fs.png/375px-PBB_GE_ACHE_205377_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PBB_GE_ACHE_205377_s_at_fs.png/500px-PBB_GE_ACHE_205377_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ACHE_205378_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/PBB_GE_ACHE_205378_s_at_fs.png/250px-PBB_GE_ACHE_205378_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/PBB_GE_ACHE_205378_s_at_fs.png/375px-PBB_GE_ACHE_205378_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d3/PBB_GE_ACHE_205378_s_at_fs.png/500px-PBB_GE_ACHE_205378_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/43/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005518">collagen binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042166">acetylcholine binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017171">serine hydrolase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0052689">carboxylic ester hydrolase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001540">amyloid-beta binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004104">cholinesterase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043621">protein self-association</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043236">laminin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016787">hydrolase activity</a></li> <li><a href="https://www.wikidata.org/wiki/Q407983" class="extiw" title="d:Q407983">ACHE</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003990">acetylcholinesterase activity</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005794">Golgi apparatus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045202">synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">cell surface</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030054">cell junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048471">perinuclear region of cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031225">anchored component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043083">synaptic cleft</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031594">neuromuscular junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005604">basement membrane</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007517">muscle organ development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031623">receptor internalization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042136">neurotransmitter biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032223">negative regulation of synaptic transmission, cholinergic</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042982">amyloid precursor protein metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051262">protein tetramerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006581">acetylcholine catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007399">nervous system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042135">neurotransmitter catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006260">DNA replication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060041">retina development in camera-type eye</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009611">response to wounding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050714">positive regulation of protein secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002076">osteoblast development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007416">synapse assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006656">phosphatidylcholine biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001919">regulation of receptor recycling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008283">cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001507">acetylcholine catabolic process in synaptic cleft</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0120162">positive regulation of cold-induced thermogenesis</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=43&rn=1">43</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=11423&rn=1">11423</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000087085;db=core">ENSG00000087085</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000023328;db=core">ENSMUSG00000023328</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P22303">P22303</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P21836">P21836</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000665">NM_000665</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001282449">NM_001282449</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001302621">NM_001302621</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001302622">NM_001302622</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_015831">NM_015831</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367915">NM_001367915</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367917">NM_001367917</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367918">NM_001367918</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001367919">NM_001367919</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001290010">NM_001290010</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009599">NM_009599</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000656">NP_000656</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001269378">NP_001269378</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001289550">NP_001289550</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001289551">NP_001289551</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354844">NP_001354844</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354846">NP_001354846</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354847">NP_001354847</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001354848">NP_001354848</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276939">NP_001276939</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_033729">NP_033729</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr7:100889994-100896974">Chr 7: 100.89 – 100.9 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr5:137285781-137292728">Chr 5: 137.29 – 137.29 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q407983" class="extiw" title="d:Q407983">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18218493" class="extiw" title="d:Q18218493">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Acetylcholinesterase</b> (<a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a> symbol <b>ACHE</b>; EC 3.1.1.7; systematic name <b>acetylcholine acetylhydrolase</b>), also known as <b>AChE, AChase</b> or <b>acetylhydrolase</b>, is the primary <a href="/wiki/Cholinesterase" title="Cholinesterase">cholinesterase</a> in the body. It is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that <a href="/wiki/Catalysis" title="Catalysis">catalyzes</a> the breakdown of <a href="/wiki/Acetylcholine" title="Acetylcholine">acetylcholine</a> and some other <a href="/wiki/Choline" title="Choline">choline</a> esters that function as <a href="/wiki/Neurotransmitter" title="Neurotransmitter">neurotransmitters</a>: </p> <dl><dd>acetylcholine + H<sub>2</sub>O = choline + acetate</dd></dl> <p>It is found at mainly <a href="/wiki/Neuromuscular_junction" title="Neuromuscular junction">neuromuscular junctions</a> and in <a href="/wiki/Chemical_synapse" title="Chemical synapse">chemical synapses</a> of the <a href="/wiki/Cholinergic" title="Cholinergic">cholinergic</a> type, where its activity serves to terminate cholinergic <a href="/wiki/Neurotransmission" title="Neurotransmission">synaptic transmission</a>. It belongs to the <a href="/wiki/Carboxylesterase_family" class="mw-redirect" title="Carboxylesterase family">carboxylesterase family</a> of enzymes. It is the primary target of inhibition by <a href="/wiki/Organophosphorus_compound" class="mw-redirect" title="Organophosphorus compound">organophosphorus compounds</a> such as <a href="/wiki/Nerve_agent" title="Nerve agent">nerve agents</a> and <a href="/wiki/Pesticide" title="Pesticide">pesticides</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Enzyme_structure_and_mechanism">Enzyme structure and mechanism</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=1" title="Edit section: Enzyme structure and mechanism"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:AChe_mechanism_of_action.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/89/AChe_mechanism_of_action.jpg/220px-AChe_mechanism_of_action.jpg" decoding="async" width="220" height="253" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/89/AChe_mechanism_of_action.jpg/330px-AChe_mechanism_of_action.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/8/89/AChe_mechanism_of_action.jpg 2x" data-file-width="434" data-file-height="499" /></a><figcaption>AChe mechanism of action<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>AChE is a <a href="/wiki/Hydrolase" title="Hydrolase">hydrolase</a> that <a href="/wiki/Hydrolyzes" class="mw-redirect" title="Hydrolyzes">hydrolyzes</a> choline esters. It has a very high <a href="/wiki/Catalytic" class="mw-redirect" title="Catalytic">catalytic</a> activity—each molecule of AChE degrades about 5,000 molecules of <a href="/wiki/Acetylcholine" title="Acetylcholine">acetylcholine</a> (ACh) per second,<sup id="cite_ref-:0_6-0" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> approaching the limit allowed by <a href="/wiki/Diffusion" title="Diffusion">diffusion</a> of the <a href="/wiki/Enzyme_substrate_(biology)" class="mw-redirect" title="Enzyme substrate (biology)">substrate</a>.<sup id="cite_ref-Quinn_1987_7-0" class="reference"><a href="#cite_note-Quinn_1987-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Active_site" title="Active site">active site</a> of AChE comprises two subsites—the anionic site and the esteratic subsite. The structure and mechanism of action of AChE have been elucidated from the crystal structure of the enzyme.<sup id="cite_ref-pmid1678899_9-0" class="reference"><a href="#cite_note-pmid1678899-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8343975_10-0" class="reference"><a href="#cite_note-pmid8343975-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The anionic subsite accommodates the positive quaternary <a href="/wiki/Amine" title="Amine">amine</a> of acetylcholine as well as other cationic substrates and <a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">inhibitors</a>. The cationic substrates are not bound by a negatively charged amino acid in the anionic site, but by interaction of 14 <a href="/wiki/Aromatic" class="mw-redirect" title="Aromatic">aromatic</a> residues that line a gorge leading to the active site.<sup id="cite_ref-pmid1356436_11-0" class="reference"><a href="#cite_note-pmid1356436-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7836436_12-0" class="reference"><a href="#cite_note-pmid7836436-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9742217_13-0" class="reference"><a href="#cite_note-pmid9742217-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> All 14 amino acids in the aromatic gorge are highly conserved across different species.<sup id="cite_ref-pmid8349597_14-0" class="reference"><a href="#cite_note-pmid8349597-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Among the aromatic amino acids, <a href="/wiki/Tryptophan" title="Tryptophan">tryptophan</a> 84 is critical and its <a href="/wiki/Alanine_scanning" title="Alanine scanning">substitution with alanine</a> results in a 3000-fold decrease in reactivity.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> The gorge is approximately 20 <a href="/wiki/Angstrom" title="Angstrom">angstroms</a> deep and five angstroms wide.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>The esteratic subsite, where acetylcholine is hydrolyzed to acetate and choline, contains the <a href="/wiki/Catalytic_triad" title="Catalytic triad">catalytic triad</a> of three amino acids: <a href="/wiki/Serine" title="Serine">serine</a> 203, <a href="/wiki/Histidine" title="Histidine">histidine</a> 447 and <a href="/wiki/Glutamate" class="mw-redirect" title="Glutamate">glutamate</a> 334. These three amino acids are similar to the triad in other <a href="/wiki/Serine_proteases" class="mw-redirect" title="Serine proteases">serine proteases</a> except that the glutamate is the third member rather than <a href="/wiki/Aspartate" class="mw-redirect" title="Aspartate">aspartate</a>. Moreover, the triad is of opposite chirality to that of other proteases.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> The hydrolysis reaction of the carboxyl ester leads to the formation of an acyl-enzyme and free <a href="/wiki/Choline" title="Choline">choline</a>. Then, the acyl-enzyme undergoes <a href="/wiki/Nucleophilic" class="mw-redirect" title="Nucleophilic">nucleophilic</a> attack by a water molecule, assisted by the histidine 440 group, liberating <a href="/wiki/Acetic_acid" title="Acetic acid">acetic acid</a> and regenerating the free enzyme.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Species">Species</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=2" title="Edit section: Species"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>AChE is found in many biological species, including humans and other mammals, non-vertebrates, and plants.<sup id="cite_ref-s00344_20-0" class="reference"><a href="#cite_note-s00344-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-s10646-006-0075-3_22-0" class="reference"><a href="#cite_note-s10646-006-0075-3-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-s42995-020-00065-9_23-0" class="reference"><a href="#cite_note-s42995-020-00065-9-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>In humans, AChE is a cholinergic enzyme involved in the hydrolysis of the neurotransmitter acetylcholine (ACh) into its constituents, choline, and acetate.<sup id="cite_ref-s00344_20-1" class="reference"><a href="#cite_note-s00344-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Overall, in mammals, AChE is primarily involved in the termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine.<sup id="cite_ref-s00344_20-2" class="reference"><a href="#cite_note-s00344-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> In non-vertebrates, AChE plays a similar role in nerve conduction processes at the neuromuscular junction. It is usually located in the membranes of these animals and controls ionic currents in excitable membranes.<sup id="cite_ref-s10646-006-0075-3_22-1" class="reference"><a href="#cite_note-s10646-006-0075-3-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-s42995-020-00065-9_23-1" class="reference"><a href="#cite_note-s42995-020-00065-9-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>In plants, the biological functions of AChE are less clear, and its existence has been recognized by indirect evidence of its activity. For instance, a study on <a href="/wiki/Solanum_lycopersicum" class="mw-redirect" title="Solanum lycopersicum">Solanum lycopersicum</a> (tomato) identified 87 SlAChE genes containing GDSL lipase/acylhydrolase domain. The study also showed up-and down-regulation of SlAChE genes under salinity stress condition.<sup id="cite_ref-s00344_20-3" class="reference"><a href="#cite_note-s00344-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p><p>Some marine fungi have been found to produce compounds that inhibit AChE. However, the specific role and mechanisms of AChE in fungi are not as well-studied as in mammals.<sup id="cite_ref-s42995-020-00065-9_23-2" class="reference"><a href="#cite_note-s42995-020-00065-9-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> The presence and role of AChE in bacteria is not well-documented.<sup id="cite_ref-s42995-020-00065-9_23-3" class="reference"><a href="#cite_note-s42995-020-00065-9-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Biological_function">Biological function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=3" title="Edit section: Biological function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>During <a href="/wiki/Neurotransmission" title="Neurotransmission">neurotransmission</a>, ACh is released from the presynaptic neuron into the <a href="/wiki/Synapse" title="Synapse">synaptic</a> cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE is concentrated in the synaptic cleft, where it terminates the signal transmission by hydrolyzing ACh.<sup id="cite_ref-:0_6-1" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The liberated choline is taken up again by the pre-synaptic neuron and ACh is synthesized by combining with <a href="/wiki/Acetyl-CoA" title="Acetyl-CoA">acetyl-CoA</a> through the action of <a href="/wiki/Choline_acetyltransferase" title="Choline acetyltransferase">choline acetyltransferase</a>.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p><p>A <a href="/wiki/Cholinomimetic" class="mw-redirect" title="Cholinomimetic">cholinomimetic</a> drug disrupts this process by acting as a cholinergic neurotransmitter that is impervious to acetylcholinesterase's lysing action.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (May 2024)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Disease_relevance">Disease relevance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=4" title="Edit section: Disease relevance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Acetylcholinesterase_inhibitor" title="Acetylcholinesterase inhibitor">Acetylcholinesterase inhibitor</a></div> <p>Drugs or toxins that <a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">inhibit</a> AChE lead to persistence of high concentrations of ACh within synapses, leading to increased cholinergic signaling within the <a href="/wiki/Central_nervous_system" title="Central nervous system">central nervous system</a>, <a href="/wiki/Autonomic_ganglion" title="Autonomic ganglion">autonomic ganglia</a> and <a href="/wiki/Neuromuscular_junction" title="Neuromuscular junction">neuromuscular junctions</a>.<sup id="cite_ref-English_26-0" class="reference"><a href="#cite_note-English-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:AChe_inhibitors_pic.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/AChe_inhibitors_pic.jpg/220px-AChe_inhibitors_pic.jpg" decoding="async" width="220" height="277" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/AChe_inhibitors_pic.jpg/330px-AChe_inhibitors_pic.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/0/08/AChe_inhibitors_pic.jpg 2x" data-file-width="434" data-file-height="546" /></a><figcaption>Mechanism of Inhibitors of AChE</figcaption></figure> <p>Irreversible inhibitors of AChE may lead to muscular <a href="/wiki/Paralysis" title="Paralysis">paralysis</a>, convulsions, <a href="/wiki/Bronchial" class="mw-redirect" title="Bronchial">bronchial</a> constriction, and death by <a href="/wiki/Asphyxiation" class="mw-redirect" title="Asphyxiation">asphyxiation</a>. <a href="/wiki/Organophosphates" class="mw-redirect" title="Organophosphates">Organophosphates</a> (OP), esters of phosphoric acid, are a class of irreversible AChE inhibitors.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Cleavage of OP by AChE leaves a phosphoryl group in the esteratic site, which is slow to be hydrolyzed (on the order of days) and can become <a href="/wiki/Covalently" class="mw-redirect" title="Covalently">covalently</a> bound. Irreversible AChE inhibitors have been used in <a href="/wiki/Insecticides" class="mw-redirect" title="Insecticides">insecticides</a> (e.g., <a href="/wiki/Malathion" title="Malathion">malathion</a>) and nerve gases for chemical warfare (e.g., <a href="/wiki/Sarin" title="Sarin">Sarin</a> and <a href="/wiki/VX_(nerve_agent)" title="VX (nerve agent)">VX</a>). <a href="/wiki/Carbamates" class="mw-redirect" title="Carbamates">Carbamates</a>, esters of N-methyl carbamic acid, are AChE inhibitors that hydrolyze in hours and have been used for medical purposes (e.g., <a href="/wiki/Physostigmine" title="Physostigmine">physostigmine</a> for the treatment of <a href="/wiki/Glaucoma" title="Glaucoma">glaucoma</a>). Reversible inhibitors occupy the esteratic site for short periods of time (seconds to minutes) and are used to treat of a range of central nervous system diseases. Tetrahydroaminoacridine (THA) and <a href="/wiki/Donepezil" title="Donepezil">donepezil</a> are FDA-approved to improve cognitive function in <a href="/wiki/Alzheimer%27s_disease" title="Alzheimer's disease">Alzheimer's disease</a>. <a href="/wiki/Rivastigmine" title="Rivastigmine">Rivastigmine</a> is also used to treat Alzheimer's and <a href="/wiki/Lewy_body_dementia" title="Lewy body dementia">Lewy body dementia</a>, and <a href="/wiki/Pyridostigmine" title="Pyridostigmine">pyridostigmine</a> bromide is used to treat <a href="/wiki/Myasthenia_gravis" title="Myasthenia gravis">myasthenia gravis</a>.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-isbn0-07-146804-8_31-0" class="reference"><a href="#cite_note-isbn0-07-146804-8-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p><p>An endogenous inhibitor of AChE in neurons is <a href="/wiki/Mir-132_microRNA" class="mw-redirect" title="Mir-132 microRNA">Mir-132 microRNA</a>, which may limit inflammation in the brain by silencing the expression of this protein and allowing ACh to act in an anti-inflammatory capacity.<sup id="cite_ref-pmid20005135_34-0" class="reference"><a href="#cite_note-pmid20005135-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p><p>It has also been shown that the main active ingredient in cannabis, <a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">tetrahydrocannabinol</a>, is a competitive inhibitor of acetylcholinesterase.<sup id="cite_ref-pmid17140265_35-0" class="reference"><a href="#cite_note-pmid17140265-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Distribution">Distribution</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=5" title="Edit section: Distribution"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>AChE is found in many types of conducting tissue: nerve and muscle, central and peripheral tissues, motor and sensory fibers, and cholinergic and noncholinergic fibers. The activity of AChE is higher in motor neurons than in sensory neurons.<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> </p><p>Acetylcholinesterase is also found on the <a href="/wiki/Red_blood_cell" title="Red blood cell">red blood cell</a> membranes, where different forms constitute the <a href="/wiki/Yt_blood_group" class="mw-redirect" title="Yt blood group">Yt blood group</a> <a href="/wiki/Antigen" title="Antigen">antigens</a>.<sup id="cite_ref-pmid8488842_39-0" class="reference"><a href="#cite_note-pmid8488842-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> Acetylcholinesterase exists in multiple molecular forms, which possess similar catalytic properties, but differ in their <a href="/wiki/Oligomeric" class="mw-redirect" title="Oligomeric">oligomeric</a> assembly and mode of attachment to the cell surface.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (May 2024)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="AChE_gene">AChE gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=6" title="Edit section: AChE gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In mammals, acetylcholinesterase is encoded by a single AChE gene while some invertebrates have multiple acetylcholinesterase genes. Note higher vertebrates also encode a closely related paralog BCHE (butyrylcholinesterase) with 50% amino acid identity to ACHE.<sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> Diversity in the transcribed products from the sole mammalian gene arises from alternative <a href="/wiki/Alternative_splicing" title="Alternative splicing">mRNA splicing</a> and <a href="/wiki/Post-translational" class="mw-redirect" title="Post-translational">post-translational</a> associations of catalytic and structural subunits. There are three known forms: T (tail), R (read through), and H (hydrophobic).<sup id="cite_ref-pmid18541228_41-0" class="reference"><a href="#cite_note-pmid18541228-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="AChET">AChE<sub>T</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=7" title="Edit section: AChET"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The major form of acetylcholinesterase found in brain, muscle, and other tissues, known as is the hydrophilic species, which forms disulfide-linked oligomers with <a href="/wiki/Collagen" title="Collagen">collagenous</a>, or <a href="/wiki/Lipid" title="Lipid">lipid</a>-containing structural subunits. In the neuromuscular junctions AChE expresses in asymmetric form which associates with <a href="/wiki/COLQ" title="COLQ">ColQ</a> or subunit. In the central nervous system it is associated with <a href="/wiki/PRIMA1" title="PRIMA1">PRiMA</a> which stands for Proline Rich Membrane anchor to form symmetric form. In either case, the ColQ or PRiMA anchor serves to maintain the enzyme in the intercellular junction, <a href="/wiki/ColQ" class="mw-redirect" title="ColQ">ColQ</a> for the neuromuscular junction and PRiMA for synapses. </p> <div class="mw-heading mw-heading3"><h3 id="AChEH">AChE<sub>H</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=8" title="Edit section: AChEH"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The other, alternatively spliced form expressed primarily in the <a href="/wiki/Red_blood_cell" title="Red blood cell">erythroid</a> tissues, differs at the <a href="/wiki/C-terminus" title="C-terminus">C-terminus</a>, and contains a cleavable <a href="/wiki/Hydrophobic" class="mw-redirect" title="Hydrophobic">hydrophobic</a> <a href="/wiki/Peptide" title="Peptide">peptide</a> with a <a href="/wiki/Glycophosphatidylinositol" class="mw-redirect" title="Glycophosphatidylinositol">PI-anchor</a> site. It associates with <a href="/wiki/Cell_membrane" title="Cell membrane">membranes</a> through the <a href="/wiki/Phosphoinositide" class="mw-redirect" title="Phosphoinositide">phosphoinositide</a> (PI) moieties added post-translationally.<sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="AChER">AChE<sub>R</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=9" title="Edit section: AChER"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The third type has, so far, only been found in <i>Torpedo</i> sp. and mice although it is hypothesized in other species. It is thought to be involved in the stress response and, possibly, inflammation.<sup id="cite_ref-pmid17379257_43-0" class="reference"><a href="#cite_note-pmid17379257-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Nomenclature">Nomenclature</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=10" title="Edit section: Nomenclature"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The nomenclatural variations of ACHE and of cholinesterases generally are discussed at <i><a href="/wiki/Cholinesterase#Types_and_nomenclature" title="Cholinesterase">Cholinesterase § Types and nomenclature</a></i>. </p> <div class="mw-heading mw-heading2"><h2 id="Inhibitors">Inhibitors</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=11" title="Edit section: Inhibitors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Acetylcholinesterase_inhibitor" title="Acetylcholinesterase inhibitor">Acetylcholinesterase inhibitor</a></div> <p>For acetylcholine esterase (AChE), <b>reversible inhibitors</b> are those that do not irreversibly bond to and deactivate AChE.<sup id="cite_ref-Millard_1999_44-0" class="reference"><a href="#cite_note-Millard_1999-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> Drugs that reversibly inhibit acetylcholine esterase are being explored as treatments for <a href="/wiki/Alzheimer%27s_disease" title="Alzheimer's disease">Alzheimer's disease</a> and <a href="/wiki/Myasthenia_gravis" title="Myasthenia gravis">myasthenia gravis</a>, among others. Examples include <a href="/wiki/Tacrine" title="Tacrine">tacrine</a> and <a href="/wiki/Donepezil" title="Donepezil">donepezil</a>.<sup id="cite_ref-45" class="reference"><a href="#cite_note-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </p><p>Exposure to acetylcholinesterase inhibitors is one of several studied explanations for the chronic cognitive symptoms veterans displayed after returning from the <a href="/wiki/Gulf_War" title="Gulf War">Gulf War</a>. Soldiers were dosed with AChEI <a href="/wiki/Pyridostigmine" title="Pyridostigmine">pyridostigmine</a> bromide (PB) as protection from nerve agent weapons. Studying acetylcholine levels using microdialysis and <a href="/wiki/HPLC" class="mw-redirect" title="HPLC">HPLC</a>-ECD, researchers at the University of South Carolina School of Medicine determined PB, when combined with a stress element can lead to cognitive responses.<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Cannabinoid" title="Cannabinoid">Phytocannabinoids</a><sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> <ul><li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/%CE%94-8-Tetrahydrocannabinol" title="Δ-8-Tetrahydrocannabinol">Δ<sup>8</sup>-Tetrahydrocannabinol</a></li> <li><a href="/wiki/Cannabigerol" title="Cannabigerol">Cannabigerol</a></li> <li><a href="/wiki/Cannabigerolic_acid" title="Cannabigerolic acid">Cannabigerolic acid</a></li> <li><a href="/wiki/Cannabicitran" title="Cannabicitran">Cannabicitran</a></li> <li><a href="/wiki/Cannabidivarin" title="Cannabidivarin">Cannabidivarin</a></li> <li><a href="/wiki/Cannabichromene" title="Cannabichromene">Cannabichromene</a></li> <li><a href="/wiki/Cannabinol" title="Cannabinol">Cannabinol</a></li></ul></li></ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=12" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterases</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=13" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output 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0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon 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href="https://pubmed.ncbi.nlm.nih.gov/30953774">30953774</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Brain%2C+Behavior%2C+and+Immunity&rft.atitle=Pyridostigmine+bromide+and+stress+interact+to+impact+immune+function%2C+cholinergic+neurochemistry+and+behavior+in+a+rat+model+of+Gulf+War+Illness&rft.volume=80&rft.pages=%3Cspan+class%3D%22nowrap%22%3E384-%3C%2Fspan%3E393&rft.date=2019-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6790976%23id-name%3DPMC&rft_id=info%3Apmid%2F30953774&rft_id=info%3Adoi%2F10.1016%2Fj.bbi.2019.04.015&rft.aulast=Macht&rft.aufirst=VA&rft.au=Woodruff%2C+JL&rft.au=Maissy%2C+ES&rft.au=Grillo%2C+CA&rft.au=Wilson%2C+MA&rft.au=Fadel%2C+JR&rft.au=Reagan%2C+LP&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6790976&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAcetylcholinesterase" class="Z3988"></span></span> </li> <li id="cite_note-47"><span class="mw-cite-backlink"><b><a href="#cite_ref-47">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPuopoloLiuMaSeeram2022" class="citation journal cs1">Puopolo T, Liu C, Ma H, Seeram NP (April 19, 2022). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149358">"Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities"</a>. <i>Medical Cannabis and Cannabinoids</i>. <b>5</b> (1): <span class="nowrap">85–</span>94. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000524086">10.1159/000524086</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149358">9149358</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/35702400">35702400</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Medical+Cannabis+and+Cannabinoids&rft.atitle=Inhibitory+Effects+of+Cannabinoids+on+Acetylcholinesterase+and+Butyrylcholinesterase+Enzyme+Activities&rft.volume=5&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E85-%3C%2Fspan%3E94&rft.date=2022-04-19&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9149358%23id-name%3DPMC&rft_id=info%3Apmid%2F35702400&rft_id=info%3Adoi%2F10.1159%2F000524086&rft.aulast=Puopolo&rft.aufirst=T&rft.au=Liu%2C+C&rft.au=Ma%2C+H&rft.au=Seeram%2C+NP&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9149358&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAcetylcholinesterase" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=14" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 32em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSilmanFuterman1988" class="citation journal cs1">Silman I, Futerman AH (1988). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1432-1033.1987.tb13662.x">"Modes of attachment of acetylcholinesterase to the surface membrane"</a>. <i>Eur. J. 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Prog.+Brain+Res.&rft.atitle=Molecular+and+Cellular+Biology+of+Cholinesterases&rft.volume=41&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E31-%3C%2Fspan%3E91&rft.date=1993&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A21601586%23id-name%3DS2CID&rft_id=info%3Apmid%2F8321908&rft_id=info%3Adoi%2F10.1016%2F0301-0082%2893%2990040-Y&rft.aulast=Massouli%C3%A9&rft.aufirst=J&rft.au=Pezzementi%2C+L&rft.au=Bon%2C+S&rft.au=Krejci%2C+E&rft.au=Vallette%2C+FM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAcetylcholinesterase" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Acetylcholinesterase&action=edit&section=15" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://www.atsdr.cdc.gov/csem/cholinesterase-inhibitors/inhibitors.html">ATSDR Case Studies in Environmental Medicine: Cholinesterase Inhibitors, Including Insecticides and Chemical Warfare Nerve Agents</a> U.S. <a href="/wiki/Department_of_Health_and_Human_Services" class="mw-redirect" title="Department of Health and Human Services">Department of Health and Human Services</a></li> <li><i><a href="/wiki/Proteopedia" title="Proteopedia">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/Acetylcholinesterase">Acetylcholinesterase</a></i></li> <li><i><a href="/wiki/Proteopedia" title="Proteopedia">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/AChE_inhibitors_and_substrates">AChE_inhibitors_and_substrates</a></i></li> <li><i><a href="/wiki/Proteopedia" title="Proteopedia">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/AChE_inhibitors_and_substrates_(Part_II)">AChE_inhibitors_and_substrates_(Part_II)</a></i></li> <li><i><a href="/wiki/Proteopedia" title="Proteopedia">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/AChE_bivalent_inhibitors">AChE bivalent inhibitors AChE_bivalent_inhibitors AChE bivalent inhibitors</a></i></li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20190301095524/http://www.ebi.ac.uk/pdbe/quips?story=AChE">Acetylcholinesterase: A gorge-ous enzyme</a>—PDBe</li> <li><a rel="nofollow" class="external text" href="https://pdb101.rcsb.org/motm/54">Acetylcholinesterase</a>—RCSB PDB</li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ACHE"><i>ACHE</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ACHE"><i>ACHE</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P22303">P22303</a></i> (Human Acetylcholinesterase) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output 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rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes_involved_in_neurotransmission167" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Neurotransmitter_metabolism_enzymes" title="Template:Neurotransmitter metabolism enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Neurotransmitter_metabolism_enzymes" title="Template 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href="/wiki/Histidine" title="Histidine">histidine</a> → <a href="/wiki/Histamine" title="Histamine">histamine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histidine_decarboxylase" title="Histidine decarboxylase">Histidine decarboxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histamine_N-methyltransferase" title="Histamine N-methyltransferase">Histamine N-methyltransferase</a></li> <li><a href="/wiki/Diamine_oxidase" title="Diamine oxidase">Diamine oxidase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine" title="Tyrosine">tyrosine</a>→<a href="/wiki/Dopamine" title="Dopamine">dopamine</a>→<a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">epinephrine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine_hydroxylase" title="Tyrosine hydroxylase">Tyrosine hydroxylase</a></li> <li><a href="/wiki/Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">Aromatic <small>L</small>-amino acid decarboxylase</a></li> <li><a href="/wiki/Dopamine_beta-hydroxylase" title="Dopamine beta-hydroxylase">Dopamine beta-hydroxylase</a></li> <li><a href="/wiki/Phenylethanolamine_N-methyltransferase" title="Phenylethanolamine N-methyltransferase">Phenylethanolamine N-methyltransferase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Catechol-O-methyl_transferase" class="mw-redirect" title="Catechol-O-methyl transferase">Catechol-O-methyl transferase</a></li> <li><a href="/wiki/Monoamine_oxidase" title="Monoamine oxidase">Monoamine oxidase</a> <ul><li><a href="/wiki/Monoamine_oxidase_A" title="Monoamine oxidase A">A</a></li> <li><a href="/wiki/Monoamine_oxidase_B" title="Monoamine oxidase B">B</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Glutamic_acid" title="Glutamic acid">glutamate</a>→<a href="/wiki/Gamma-Aminobutyric_acid" class="mw-redirect" title="Gamma-Aminobutyric acid">GABA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glutamate_decarboxylase" title="Glutamate decarboxylase">Glutamate decarboxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4-aminobutyrate_transaminase" title="4-aminobutyrate transaminase">4-aminobutyrate transaminase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tryptophan" title="Tryptophan">tryptophan</a>→<a href="/wiki/Serotonin" title="Serotonin">serotonin</a>→<a href="/wiki/Melatonin" title="Melatonin">melatonin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tryptophan_hydroxylase" title="Tryptophan hydroxylase">Tryptophan hydroxylase</a></li> <li><a href="/wiki/Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">Aromatic <small>L</small>-amino acid decarboxylase</a></li> <li><a href="/wiki/Aralkylamine_N-acetyltransferase" title="Aralkylamine N-acetyltransferase">Aralkylamine N-acetyltransferase</a></li> <li><a href="/wiki/Acetylserotonin_O-methyltransferase" title="Acetylserotonin O-methyltransferase">Acetylserotonin O-methyltransferase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Arginine" title="Arginine">arginine</a>→<a href="/wiki/Nitric_oxide" title="Nitric oxide">NO</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthase</a> (<a href="/wiki/NOS1" title="NOS1">NOS1</a>, <a href="/wiki/Nitric_oxide_synthase_2_(inducible)" title="Nitric oxide synthase 2 (inducible)">NOS2</a>, <a href="/wiki/Endothelial_NOS" title="Endothelial NOS">NOS3</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Choline" title="Choline">choline</a>→<a href="/wiki/Acetylcholine" title="Acetylcholine">Acetylcholine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Choline_acetyltransferase" title="Choline acetyltransferase">Choline acetyltransferase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a> (<a class="mw-selflink selflink">Acetylcholinesterase</a>, <a href="/wiki/Butyrylcholinesterase" title="Butyrylcholinesterase">Butyrylcholinesterase</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Hydrolase:_esterases_(EC_3.1)635" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Esterases" title="Template:Esterases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Esterases" title="Template talk:Esterases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Esterases" title="Special:EditPage/Template:Esterases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Hydrolase:_esterases_(EC_3.1)635" style="font-size:114%;margin:0 4em"><a href="/wiki/Hydrolase" title="Hydrolase">Hydrolase</a>: <a href="/wiki/Esterase" title="Esterase">esterases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 3.1)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.1:_Carboxylic_Ester_Hydrolases" title="List of EC numbers (EC 3)">3.1.1</a>: <a href="/wiki/Carboxylic_acid" title="Carboxylic acid">Carboxylic</a><br />ester hydrolases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a> <ul><li><a class="mw-selflink selflink">Acetylcholinesterase</a></li> <li><a href="/wiki/Butyrylcholinesterase" title="Butyrylcholinesterase">Butyrylcholinesterase</a></li></ul></li> <li><a href="/wiki/Pectinesterase" title="Pectinesterase">Pectinesterase</a></li> <li><a href="/wiki/6-phosphogluconolactonase" title="6-phosphogluconolactonase">6-phosphogluconolactonase</a></li> <li><a href="/wiki/PAF_acetylhydrolase" class="mw-redirect" title="PAF acetylhydrolase">PAF acetylhydrolase</a></li></ul> <ul><li><a href="/wiki/Lipase" title="Lipase">Lipase</a> <ul><li><a href="/wiki/Bile_salt-dependent_lipase" title="Bile salt-dependent lipase">Bile salt-dependent</a></li> <li><a href="/wiki/Gastric_lipase" title="Gastric lipase">Gastric</a>/<a href="/wiki/Lingual_lipase" title="Lingual lipase">Lingual</a></li> <li><a href="/wiki/Pancreatic_lipase" class="mw-redirect" title="Pancreatic lipase">Pancreatic</a></li> <li><a href="/wiki/Lysosomal_lipase" title="Lysosomal lipase">Lysosomal</a></li> <li><a href="/wiki/Hormone-sensitive_lipase" title="Hormone-sensitive lipase">Hormone-sensitive</a></li> <li><a href="/wiki/Endothelial_lipase" title="Endothelial lipase">Endothelial</a></li> <li><a href="/wiki/Hepatic_lipase" title="Hepatic lipase">Hepatic</a></li> <li><a href="/wiki/Lipoprotein_lipase" title="Lipoprotein lipase">Lipoprotein</a></li> <li><a href="/wiki/Monoacylglycerol_lipase" title="Monoacylglycerol lipase">Monoacylglycerol</a></li> <li><a href="/wiki/Diacylglycerol_lipase" title="Diacylglycerol lipase">Diacylglycerol</a></li></ul></li></ul> <ul><li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_A1" title="Phospholipase A1">A1</a></li> <li><a href="/wiki/Phospholipase_A2" title="Phospholipase A2">A2</a></li> <li><a href="/wiki/Phospholipase_B" title="Phospholipase B">B</a></li></ul></li></ul> <ul><li><a href="/wiki/Cutinase" title="Cutinase">Cutinase</a></li> <li><a href="/wiki/PETase" title="PETase">PETase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.2:_Thioester_Hydrolases" title="List of EC numbers (EC 3)">3.1.2</a>: <a href="/wiki/Thioesterase" title="Thioesterase">Thioesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Palmitoyl_protein_thioesterase" class="mw-redirect" title="Palmitoyl protein thioesterase">Palmitoyl protein thioesterase</a></li> <li><a href="/wiki/Ubiquitin_carboxy-terminal_hydrolase_L1" title="Ubiquitin carboxy-terminal hydrolase L1">Ubiquitin carboxy-terminal hydrolase L1</a></li> <li><a href="/wiki/4-hydroxybenzoyl-CoA_thioesterase" title="4-hydroxybenzoyl-CoA thioesterase">4-hydroxybenzoyl-CoA thioesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.3:_Phosphoric_Monoester_Hydrolases" title="List of EC numbers (EC 3)">3.1.3</a>: <a href="/wiki/Phosphatase" title="Phosphatase">Phosphatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alkaline_phosphatase" title="Alkaline phosphatase">Alkaline phosphatase</a> <ul><li><a href="/wiki/ALPI" title="ALPI">ALPI</a></li> <li><a href="/wiki/ALPL" title="ALPL">ALPL</a></li> <li><a href="/wiki/Placental_alkaline_phosphatase" class="mw-redirect" title="Placental alkaline phosphatase">ALPP</a></li></ul></li> <li><a href="/wiki/Acid_phosphatase" title="Acid phosphatase">Acid phosphatase</a> (<a href="/wiki/Prostatic_acid_phosphatase" title="Prostatic acid phosphatase">Prostatic</a>)/<a href="/wiki/Tartrate-resistant_acid_phosphatase" title="Tartrate-resistant acid phosphatase">Tartrate-resistant acid phosphatase</a>/<a href="/wiki/Purple_acid_phosphatases" title="Purple acid phosphatases">Purple acid phosphatases</a></li> <li><a href="/wiki/Nucleotidase" title="Nucleotidase">Nucleotidase</a></li> <li><a href="/wiki/Glucose_6-phosphatase" title="Glucose 6-phosphatase">Glucose 6-phosphatase</a></li> <li><a href="/wiki/Fructose_1,6-bisphosphatase" title="Fructose 1,6-bisphosphatase">Fructose 1,6-bisphosphatase</a> <ul><li><a href="/wiki/Calcineurin" title="Calcineurin">Calcineurin</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a> <ul><li><a href="/wiki/PP2A" class="mw-redirect" title="PP2A">PP2A</a></li></ul></li> <li><a href="/wiki/OCRL" title="OCRL">OCRL</a></li> <li><a href="/wiki/Pyruvate_dehydrogenase_phosphatase" title="Pyruvate dehydrogenase phosphatase">Pyruvate dehydrogenase phosphatase</a></li> <li><a href="/wiki/Phosphofructokinase_2" title="Phosphofructokinase 2">Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase</a></li> <li><a href="/wiki/PTEN_(gene)" title="PTEN (gene)">PTEN</a></li> <li><a href="/wiki/Phytase" title="Phytase">Phytase</a> <ul><li><a href="/wiki/Beta-propeller_phytase" title="Beta-propeller phytase">Beta-propeller phytase</a></li></ul></li> <li><a href="/wiki/Inositol-phosphate_phosphatase" title="Inositol-phosphate phosphatase">Inositol-phosphate phosphatase</a> <ul><li><a href="/wiki/Inositol_monophosphatase_1" title="Inositol monophosphatase 1">IMPA1</a>, <a href="/wiki/Inositol_monophosphatase_2" title="Inositol monophosphatase 2">IMPA2</a>, <a href="/wiki/Inositol_monophosphatase_3" title="Inositol monophosphatase 3">IMPA3</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a>: <a href="/wiki/Protein_tyrosine_phosphatase" title="Protein tyrosine phosphatase">Protein tyrosine phosphatase</a></li> <li><a href="/wiki/Protein_serine/threonine_phosphatase" title="Protein serine/threonine phosphatase">Protein serine/threonine phosphatase</a></li> <li><a href="/wiki/Dual-specificity_phosphatase" title="Dual-specificity phosphatase">Dual-specificity phosphatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.4:_Phosphoric_Diester_Hydrolases" title="List of EC numbers (EC 3)">3.1.4</a>:<br /><a href="/wiki/Phosphodiesterase" title="Phosphodiesterase">Phosphodiesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autotaxin" title="Autotaxin">Autotaxin</a></li> <li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_C" title="Phospholipase C">C</a></li> <li><a href="/wiki/Phospholipase_D" title="Phospholipase D">D</a></li></ul></li> <li><a href="/wiki/Sphingomyelin_phosphodiesterase" title="Sphingomyelin phosphodiesterase">Sphingomyelin phosphodiesterase</a> <ul><li><a href="/wiki/Sphingomyelin_phosphodiesterase_1" title="Sphingomyelin phosphodiesterase 1">1</a></li></ul></li> <li><a href="/wiki/PDE1" title="PDE1">PDE1</a></li> <li><a href="/wiki/Phosphodiesterase_2" title="Phosphodiesterase 2">PDE2</a></li> <li><a href="/wiki/Phosphodiesterase_3" title="Phosphodiesterase 3">PDE3</a></li> <li><a href="/wiki/PDE4A" title="PDE4A">PDE4A</a>/<a href="/wiki/PDE4B" title="PDE4B">PDE4B</a></li> <li><a href="/wiki/CGMP-specific_phosphodiesterase_type_5" title="CGMP-specific phosphodiesterase type 5">PDE5</a></li> <li><a href="/wiki/Lecithinase" title="Lecithinase">Lecithinase</a> (<a href="/wiki/Clostridium_perfringens_alpha_toxin" title="Clostridium perfringens alpha toxin">Clostridium perfringens alpha toxin</a>)</li> <li><a href="/wiki/Cyclic_nucleotide_phosphodiesterase" title="Cyclic nucleotide phosphodiesterase">Cyclic nucleotide phosphodiesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.6:_Sulfuric_Ester_Hydrolases" title="List of EC numbers (EC 3)">3.1.6</a>: <a href="/wiki/Sulfatase" title="Sulfatase">Sulfatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Arylsulfatase" title="Arylsulfatase">arylsulfatase</a></i> <ul><li><a href="/wiki/Arylsulfatase_A" title="Arylsulfatase A">Arylsulfatase A</a></li> <li><a href="/wiki/Arylsulfatase_B" title="Arylsulfatase B">Arylsulfatase B</a></li> <li><a href="/wiki/Arylsulfatase_L" title="Arylsulfatase L">Arylsulfatase L</a></li> <li><a href="/wiki/Steroid_sulfatase" title="Steroid sulfatase">Steroid sulfatase</a></li></ul></li> <li><a href="/wiki/Galactosamine-6_sulfatase" title="Galactosamine-6 sulfatase">Galactosamine-6 sulfatase</a></li> <li><a href="/wiki/Iduronate-2-sulfatase" title="Iduronate-2-sulfatase">Iduronate-2-sulfatase</a></li> <li><a href="/wiki/N-acetylglucosamine-6-sulfatase" title="N-acetylglucosamine-6-sulfatase">N-acetylglucosamine-6-sulfatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nuclease" title="Nuclease">Nuclease</a> (includes<br /><a href="/wiki/Deoxyribonuclease" title="Deoxyribonuclease">deoxyribonuclease</a><br />and <a href="/wiki/Ribonuclease" title="Ribonuclease">ribonuclease</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.11:_Exodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.11</a>-16:<br /><a href="/wiki/Exonuclease" title="Exonuclease">Exonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exodeoxyribonuclease" title="Exodeoxyribonuclease">Exodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RecBCD" title="RecBCD">RecBCD</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exoribonuclease" title="Exoribonuclease">Exoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oligonucleotidase" title="Oligonucleotidase">Oligonucleotidase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.21:_Endodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.21</a>-31:<br /><a href="/wiki/Endonuclease" title="Endonuclease">Endonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endodeoxyribonuclease" title="Endodeoxyribonuclease">Endodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Deoxyribonuclease_I" title="Deoxyribonuclease I">Deoxyribonuclease I</a></li> <li><a href="/wiki/Deoxyribonuclease_II" title="Deoxyribonuclease II">Deoxyribonuclease II</a></li> <li><a href="/wiki/Deoxyribonuclease_IV" title="Deoxyribonuclease IV">Deoxyribonuclease IV</a></li> <li><a href="/wiki/Restriction_enzyme" title="Restriction enzyme">Restriction enzyme</a>;see <span class="nowrap">{{</span><a href="/wiki/Template:Restriction_enzyme" title="Template:Restriction enzyme">Restriction enzyme</a><span class="nowrap">}}</span></li> <li><a href="/wiki/UvrABC_endonuclease" title="UvrABC endonuclease">UvrABC endonuclease</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endoribonuclease" title="Endoribonuclease">Endoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RNase_III" class="mw-redirect" title="RNase III">RNase III</a> <ul><li><a href="/wiki/Drosha" title="Drosha">Drosha</a>: <a href="/wiki/Microprocessor_complex" title="Microprocessor complex">Microprocessor complex</a></li> <li><a href="/wiki/Dicer" title="Dicer">Dicer</a>: <a href="/wiki/RNA-induced_silencing_complex" title="RNA-induced silencing complex">RNA-induced silencing complex</a></li></ul></li> <li><a href="/wiki/RNase_H" class="mw-redirect" title="RNase H">RNase H</a> <ul><li><a href="/wiki/RNASEH1" title="RNASEH1">1</a></li> <li><a href="/wiki/RNASEH2A" title="RNASEH2A">2A</a></li> <li><a href="/wiki/RNASEH2B" title="RNASEH2B">2B</a></li> <li><a href="/wiki/RNASEH2C" title="RNASEH2C">2C</a></li></ul></li> <li><a href="/wiki/RNase_P" class="mw-redirect" title="RNase P">RNase P</a></li> <li><a href="/wiki/Ribonuclease_A" class="mw-redirect" title="Ribonuclease A">RNase A</a></li> <li><a href="/wiki/Ribonuclease_Z" title="Ribonuclease Z">RNase Z</a></li> <li><a href="/wiki/Ribonuclease_E" title="Ribonuclease E">RNase E</a> <ul><li><a href="/wiki/RNASE1" title="RNASE1">1</a></li> <li><a href="/wiki/Eosinophil-derived_neurotoxin" title="Eosinophil-derived neurotoxin">2</a></li> <li><a href="/wiki/Eosinophil_cationic_protein" title="Eosinophil cationic protein">3</a></li> <li><a href="/wiki/Angiogenin" title="Angiogenin">4/5</a></li></ul></li> <li><a href="/wiki/Ribonuclease_T1" title="Ribonuclease T1">RNase T1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">either deoxy- or ribo-    </th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclease_S1" title="Nuclease S1">Nuclease S1</a> <ul><li><a href="/wiki/Mung_bean_nuclease" title="Mung bean nuclease">Mung bean nuclease</a></li></ul></li> <li><a href="/wiki/Serratia_marcescens_nuclease" title="Serratia marcescens nuclease">Serratia marcescens nuclease</a></li> <li><a href="/wiki/Micrococcal_nuclease" title="Micrococcal nuclease">Micrococcal nuclease</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes56" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes56" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Acetylcholine_metabolism_and_transport_modulators653" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Acetylcholine_metabolism_and_transport_modulators" title="Template:Acetylcholine metabolism and transport modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Acetylcholine_metabolism_and_transport_modulators" title="Template talk:Acetylcholine metabolism and transport modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Acetylcholine_metabolism_and_transport_modulators" title="Special:EditPage/Template:Acetylcholine metabolism and transport modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Acetylcholine_metabolism_and_transport_modulators653" style="font-size:114%;margin:0 4em"><a href="/wiki/Acetylcholine" title="Acetylcholine">Acetylcholine</a> <a href="/wiki/Metabolism" title="Metabolism">metabolism</a> and <a href="/wiki/Neurotransmitter_transporter" title="Neurotransmitter transporter">transport</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Enzyme" title="Enzyme">Enzyme</a><br /><small>(<a href="/wiki/Enzyme_modulator" title="Enzyme modulator">modulators</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Choline_acetyltransferase" title="Choline acetyltransferase"><abbr title="Choline acetyltransferase">ChAT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Choline acetyltransferase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/w/index.php?title=1-(-Benzoylethyl)pyridinium&action=edit&redlink=1" class="new" title="1-(-Benzoylethyl)pyridinium (page does not exist)">1-(-Benzoylethyl)pyridinium</a></li> <li><a href="/w/index.php?title=2-(%CE%B1-Naphthoyl)ethyltrimethylammonium&action=edit&redlink=1" class="new" title="2-(α-Naphthoyl)ethyltrimethylammonium (page does not exist)">2-(α-Naphthoyl)ethyltrimethylammonium</a></li> <li><a href="/w/index.php?title=3-Chloro-4-stillbazole&action=edit&redlink=1" class="new" title="3-Chloro-4-stillbazole (page does not exist)">3-Chloro-4-stillbazole</a></li> <li><a href="/w/index.php?title=4-(1-Naphthylvinyl)pyridine&action=edit&redlink=1" class="new" title="4-(1-Naphthylvinyl)pyridine (page does not exist)">4-(1-Naphthylvinyl)pyridine</a></li> <li><a href="/w/index.php?title=Acetylseco_hemicholinium-3&action=edit&redlink=1" class="new" title="Acetylseco hemicholinium-3 (page does not exist)">Acetylseco hemicholinium-3</a></li> <li><a href="/w/index.php?title=Acryloylcholine&action=edit&redlink=1" class="new" title="Acryloylcholine (page does not exist)">Acryloylcholine</a></li> <li><a href="/wiki/AF64A" class="mw-redirect" title="AF64A">AF64A</a></li> <li><a href="/w/index.php?title=(E)-1-Methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine&action=edit&redlink=1" class="new" title="(E)-1-Methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine (page does not exist)">B115</a></li> <li><a href="/w/index.php?title=(2-Benzoylethyl)trimethylammonium&action=edit&redlink=1" class="new" title="(2-Benzoylethyl)trimethylammonium (page does not exist)">BETA</a></li> <li><a href="/w/index.php?title=N,N-Dimethylamino-2-ethoxyimino-2-adamantane&action=edit&redlink=1" class="new" title="N,N-Dimethylamino-2-ethoxyimino-2-adamantane (page does not exist)">CM-54,903</a></li> <li><a href="/w/index.php?title=N,N-Dimethylaminoethylacrylate&action=edit&redlink=1" class="new" title="N,N-Dimethylaminoethylacrylate (page does not exist)">N,N-Dimethylaminoethylacrylate</a></li> <li><a href="/w/index.php?title=N,N-Dimethylaminoethylchloroacetate&action=edit&redlink=1" class="new" title="N,N-Dimethylaminoethylchloroacetate (page does not exist)">N,N-Dimethylaminoethylchloroacetate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a class="mw-selflink selflink"><abbr title="Acetylcholinesterase">AChE</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Acetylcholinesterase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/Acetylcholinesterase_inhibitor" title="Acetylcholinesterase inhibitor">Inhibitors</a>:</b> <i>Reversible:</i> Carbamates: <a href="/wiki/Aldicarb" title="Aldicarb">Aldicarb</a></li> <li><a href="/wiki/Aminocarb" title="Aminocarb">Aminocarb</a></li> <li><a href="/wiki/Bendiocarb" title="Bendiocarb">Bendiocarb</a></li> <li><a href="/w/index.php?title=Bufencarb&action=edit&redlink=1" class="new" title="Bufencarb (page does not exist)">Bufencarb</a></li> <li><a href="/wiki/Carbaryl" title="Carbaryl">Carbaryl</a></li> <li><a href="/wiki/Carbendazim" title="Carbendazim">Carbendazim</a></li> <li><a href="/w/index.php?title=Carbetamide&action=edit&redlink=1" class="new" title="Carbetamide (page does not exist)">Carbetamide</a></li> <li><a href="/wiki/Carbofuran" title="Carbofuran">Carbofuran</a></li> <li><a href="/wiki/Carbosulfan" title="Carbosulfan">Carbosulfan</a></li> <li><a href="/w/index.php?title=Chlorbufam&action=edit&redlink=1" class="new" title="Chlorbufam (page does not exist)">Chlorbufam</a></li> <li><a href="/w/index.php?title=Chloropropham&action=edit&redlink=1" class="new" title="Chloropropham (page does not exist)">Chloropropham</a></li> <li><a href="/wiki/Dimetilan" title="Dimetilan">Dimetilan</a></li> <li><a href="/wiki/Ethienocarb" class="mw-redirect" title="Ethienocarb">Ethienocarb</a></li> <li><a href="/wiki/Ethiofencarb" title="Ethiofencarb">Ethiofencarb</a></li> <li><a href="/wiki/Fenobucarb" title="Fenobucarb">Fenobucarb</a></li> <li><a href="/wiki/Formetanate" title="Formetanate">Formetanate</a></li> <li><a href="/wiki/Formparanate" title="Formparanate">Formparanate</a></li> <li><a href="/wiki/Methiocarb" title="Methiocarb">Methiocarb</a></li> <li><a href="/wiki/Methomyl" title="Methomyl">Methomyl</a></li> <li><a href="/wiki/Metolcarb" title="Metolcarb">Metolcarb</a></li> <li><a href="/wiki/Miotine" title="Miotine">Miotine</a></li> <li><a href="/wiki/Oxamyl" title="Oxamyl">Oxamyl</a></li> <li><a href="/w/index.php?title=Phenmedipham&action=edit&redlink=1" class="new" title="Phenmedipham (page does not exist)">Phenmedipham</a></li> <li><a href="/w/index.php?title=Pinmicarb&action=edit&redlink=1" class="new" title="Pinmicarb (page does not exist)">Pinmicarb</a></li> <li><a href="/wiki/Pirimicarb" title="Pirimicarb">Pirimicarb</a></li> <li><a href="/wiki/Promecarb" title="Promecarb">Promecarb</a></li> <li><a href="/wiki/Propamocarb" title="Propamocarb">Propamocarb</a></li> <li><a href="/w/index.php?title=Propham&action=edit&redlink=1" class="new" title="Propham (page does not exist)">Propham</a></li> <li><a href="/wiki/Propoxur" title="Propoxur">Propoxur</a></li> <li><a href="/w/index.php?title=Thiodicarb&action=edit&redlink=1" class="new" title="Thiodicarb (page does not exist)">Thiodicarb</a></li> <li><a href="/wiki/Thiofanox" title="Thiofanox">Thiofanox</a>; Stigmines: <a href="/wiki/Distigmine" title="Distigmine">Distigmine</a></li> <li><a href="/w/index.php?title=Eptastigmine&action=edit&redlink=1" class="new" title="Eptastigmine (page does not exist)">Eptastigmine</a></li> <li><a href="/w/index.php?title=Ganstigmine&action=edit&redlink=1" class="new" title="Ganstigmine (page does not exist)">Ganstigmine</a></li> <li><a href="/wiki/Neostigmine" title="Neostigmine">Neostigmine</a> <a href="/wiki/Neostigmine/glycopyrronium_bromide" title="Neostigmine/glycopyrronium bromide">+glycopyrronium bromide</a></li> <li><a href="/wiki/Phenserine" title="Phenserine">Phenserine</a></li> <li><a href="/wiki/Physostigmine" title="Physostigmine">Physostigmine</a></li> <li><a href="/wiki/Pyridostigmine" title="Pyridostigmine">Pyridostigmine</a></li> <li><a href="/w/index.php?title=Quilostigmine&action=edit&redlink=1" class="new" title="Quilostigmine (page does not exist)">Quilostigmine</a></li> <li><a href="/wiki/Rivastigmine" title="Rivastigmine">Rivastigmine</a></li> <li><a href="/w/index.php?title=Terestigmine&action=edit&redlink=1" class="new" title="Terestigmine (page does not exist)">Terestigmine</a>; Others: <a href="/wiki/Acotiamide" title="Acotiamide">Acotiamide</a></li> <li><a href="/wiki/Ambenonium" class="mw-redirect" title="Ambenonium">Ambenonium</a></li> <li><a href="/wiki/Caffeine" title="Caffeine">Caffeine</a></li> <li><a href="/wiki/Donepezil" title="Donepezil">Donepezil</a></li> <li><a href="/wiki/EA-3990" title="EA-3990">EA-3990</a></li> <li><a href="/wiki/EA-4056" title="EA-4056">EA-4056</a></li> <li><a href="/wiki/Edrophonium" title="Edrophonium">Edrophonium</a></li> <li><a href="/wiki/Galantamine" title="Galantamine">Galantamine</a></li> <li><a href="/wiki/Huperzine_A" title="Huperzine A">Huperzine A</a></li> <li><a href="/w/index.php?title=Huprine_W&action=edit&redlink=1" class="new" title="Huprine W (page does not exist)">Huprine W</a></li> <li><a href="/wiki/Huprine_X" title="Huprine X">Huprine X</a></li> <li><a href="/w/index.php?title=Huprine_Y&action=edit&redlink=1" class="new" title="Huprine Y (page does not exist)">Huprine Y</a></li> <li><a href="/wiki/Ipidacrine" title="Ipidacrine">Ipidacrine</a></li> <li><a href="/wiki/Itopride" title="Itopride">Itopride</a></li> <li><a href="/wiki/Ladostigil" title="Ladostigil">Ladostigil</a></li> <li><a href="/wiki/Minaprine" title="Minaprine">Minaprine</a></li> <li><a href="/wiki/Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium_bromide)" title="Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)">Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)</a></li> <li><a href="/wiki/T-1123" title="T-1123">T-1123</a></li> <li><a href="/wiki/T-1152" title="T-1152">T-1152</a></li> <li><a href="/wiki/T-1194" title="T-1194">T-1194</a></li> <li><a href="/wiki/TL-599" title="TL-599">TL-599</a></li> <li><a href="/wiki/TL-1238" title="TL-1238">TL-1238</a></li> <li><a href="/wiki/Tacrine" title="Tacrine">Tacrine</a></li> <li><a href="/w/index.php?title=Zanapezil&action=edit&redlink=1" class="new" title="Zanapezil (page does not exist)">Zanapezil</a></li></ul> <ul><li><i>Irreversible:</i> Organophosphates: <a href="/wiki/2-Ethoxycarbonyl-1-methylvinyl_cyclohexyl_methylphosphonate" title="2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate">2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate</a></li> <li><a href="/wiki/Acephate" title="Acephate">Acephate</a></li> <li><a href="/wiki/Armine_(chemical)" title="Armine (chemical)">Armine</a></li> <li><a href="/wiki/Azinphos-ethyl" title="Azinphos-ethyl">Azinphos-ethyl</a></li> <li><a href="/wiki/Azinphos-methyl" title="Azinphos-methyl">Azinphos-methyl</a></li> <li><a href="/wiki/BAY-29952" title="BAY-29952">BAY-29952</a></li> <li><a href="/wiki/Bensulide" title="Bensulide">Bensulide</a></li> <li><a href="/wiki/Cadusafos" title="Cadusafos">Cadusafos</a></li> <li><a href="/wiki/Carbophenothion" title="Carbophenothion">Carbophenothion</a></li> <li><a href="/wiki/Chlorethoxyfos" title="Chlorethoxyfos">Chlorethoxyfos</a></li> <li><a href="/wiki/Chlorfenvinphos" title="Chlorfenvinphos">Chlorfenvinphos</a></li> <li><a href="/wiki/Chlorpyrifos" title="Chlorpyrifos">Chlorpyrifos</a></li> <li><a href="/wiki/Chlorpyrifos-methyl" class="mw-redirect" title="Chlorpyrifos-methyl">Chlorpyrifos-methyl</a></li> <li><a href="/wiki/Coumaphos" title="Coumaphos">Coumaphos</a></li> <li><a href="/wiki/Crotylsarin" title="Crotylsarin">Crotylsarin</a></li> <li><a href="/wiki/Cyanophos" title="Cyanophos">Cyanophos</a></li> <li><a href="/wiki/Cyclosarin" title="Cyclosarin">Cyclosarin (GF)</a></li> <li><a href="/wiki/Demephion" title="Demephion">Demephion</a></li> <li><a href="/wiki/Demeton" title="Demeton">Demeton</a></li> <li><a href="/wiki/Demeton-S-methyl" title="Demeton-S-methyl">Demeton-S-methyl</a></li> <li><a href="/wiki/Dialifor" title="Dialifor">Dialifor</a></li> <li><a href="/wiki/Diazinon" title="Diazinon">Diazinon</a></li> <li><a href="/wiki/Dichlorvos" title="Dichlorvos">Dichlorvos</a></li> <li><a href="/wiki/Dicrotophos" title="Dicrotophos">Dicrotophos</a></li> <li><a href="/wiki/Dicyclohexyl_phosphorofluoridate" title="Dicyclohexyl phosphorofluoridate">Dicyclohexyl phosphorofluoridate</a></li> <li><a href="/wiki/Diisopropylphosphate" title="Diisopropylphosphate">Diisopropylphosphate</a></li> <li><a href="/wiki/Diisopropyl_fluorophosphate" title="Diisopropyl fluorophosphate">Diisopropyl fluorophosphate</a></li> <li><a href="/wiki/Dimefox" title="Dimefox">Dimefox</a></li> <li><a href="/wiki/Dimethoate" title="Dimethoate">Dimethoate</a></li> <li><a href="/wiki/Dimethyl_4-(methylthio)phenyl_phosphate" title="Dimethyl 4-(methylthio)phenyl phosphate">Dimethyl 4-(methylthio)phenyl phosphate</a></li> <li><a href="/wiki/Dioxathion" title="Dioxathion">Dioxathion</a></li> <li><a href="/wiki/Disulfoton" title="Disulfoton">Disulfoton</a></li> <li><a href="/wiki/EA-2012" title="EA-2012">EA-2012</a></li> <li><a href="/wiki/EA-2054" title="EA-2054">EA-2054</a></li> <li><a href="/wiki/EA-2098" title="EA-2098">EA-2098</a></li> <li><a href="/wiki/EA-2192" title="EA-2192">EA-2192</a></li> <li><a href="/wiki/EA-2613" title="EA-2613">EA-2613</a></li> <li><a href="/wiki/EA-3148" title="EA-3148">EA-3148</a></li> <li><a href="/wiki/EA-4352" title="EA-4352">EA-4352</a></li> <li><a href="/wiki/Echothiophate" title="Echothiophate">Echothiophate</a></li> <li><a href="/wiki/Ethylsarin" title="Ethylsarin">Ethylsarin (GE)</a></li> <li><a href="/wiki/Endothion" title="Endothion">Endothion</a></li> <li><a href="/wiki/EPN_(insecticide)" title="EPN (insecticide)">EPN</a></li> <li><a href="/wiki/Ethion" title="Ethion">Ethion</a></li> <li><a href="/wiki/Ethoprop" class="mw-redirect" title="Ethoprop">Ethoprop</a></li> <li><a href="/wiki/Fenamiphos" title="Fenamiphos">Fenamiphos</a></li> <li><a href="/wiki/Fenitrothion" title="Fenitrothion">Fenitrothion</a></li> <li><a href="/wiki/Fenthion" title="Fenthion">Fenthion</a></li> <li><a href="/wiki/Fluorotabun" title="Fluorotabun">Fluorotabun</a></li> <li><a href="/wiki/Fonofos" title="Fonofos">Fonofos</a></li> <li><a href="/wiki/Formothion" title="Formothion">Formothion</a></li> <li><a href="/w/index.php?title=Fosthiazate&action=edit&redlink=1" class="new" title="Fosthiazate (page does not exist)">Fosthiazate</a></li> <li><a href="/wiki/GD-42" title="GD-42">GD-42</a></li> <li><a href="/wiki/GH_(nerve_agent)" title="GH (nerve agent)">GH</a></li> <li><a href="/w/index.php?title=GT-45&action=edit&redlink=1" class="new" title="GT-45 (page does not exist)">GT-45</a></li> <li><a href="/wiki/GV_(nerve_agent)" title="GV (nerve agent)">GV</a></li> <li><a href="/wiki/Guanitoxin" title="Guanitoxin">Guanitoxin</a></li> <li><a href="/wiki/Hexaethyl_tetraphosphate" title="Hexaethyl tetraphosphate">Hexaethyl tetraphosphate (HETP)</a></li> <li><a href="/wiki/Isofluorophate" class="mw-redirect" title="Isofluorophate">Isofluorophate</a></li> <li><a href="/wiki/Isoxathion" title="Isoxathion">Isoxathion</a></li> <li><a href="/wiki/Leptophos" title="Leptophos">Leptophos</a></li> <li><a href="/wiki/Malaoxon" title="Malaoxon">Malaoxon</a></li> <li><a href="/wiki/Malathion" title="Malathion">Malathion</a></li> <li><a href="/w/index.php?title=Mazidox&action=edit&redlink=1" class="new" title="Mazidox (page does not exist)">Mazidox</a></li> <li><a href="/wiki/Methamidophos" title="Methamidophos">Methamidophos</a></li> <li><a href="/wiki/Methidathion" title="Methidathion">Methidathion</a></li> <li><a href="/wiki/Methyl_phenkapton" title="Methyl phenkapton">Methyl phenkapton</a></li> <li><a href="/wiki/Methylfluorophosphonylcholine" title="Methylfluorophosphonylcholine">Methylfluorophosphonylcholine (MFPCh)</a></li> <li><a href="/wiki/Metrifonate" title="Metrifonate">Metrifonate</a></li> <li><a href="/wiki/Mevinphos" title="Mevinphos">Mevinphos</a></li> <li><a href="/wiki/Mipafox" title="Mipafox">Mipafox</a></li> <li><a href="/wiki/Monocrotophos" title="Monocrotophos">Monocrotophos</a></li> <li><a href="/wiki/MSPI_(nerve_agent)" title="MSPI (nerve agent)">MSPI</a></li> <li><a href="/wiki/Naled" title="Naled">Naled</a></li> <li><a href="/wiki/Novichok_agent" class="mw-redirect" title="Novichok agent">Novichok agent</a></li> <li><a href="/wiki/Omethoate" title="Omethoate">Omethoate</a></li> <li><a href="/wiki/Oxydemeton-methyl" title="Oxydemeton-methyl">Oxydemeton-methyl</a></li> <li><a href="/wiki/Paraoxon" title="Paraoxon">Paraoxon</a></li> <li><a href="/wiki/Parathion" title="Parathion">Parathion</a></li> <li><a href="/wiki/Parathion-methyl" class="mw-redirect" title="Parathion-methyl">Parathion-methyl</a></li> <li><a href="/wiki/Phorate" title="Phorate">Phorate</a></li> <li><a href="/wiki/Phosalone" title="Phosalone">Phosalone</a></li> <li><a href="/wiki/Phosfolan" title="Phosfolan">Phosfolan</a></li> <li><a href="/wiki/Phosmet" title="Phosmet">Phosmet</a></li> <li><a href="/wiki/Phosphamidon" title="Phosphamidon">Phosphamidon</a></li> <li><a href="/wiki/Phoxim" title="Phoxim">Phoxim</a></li> <li><a href="/wiki/Pirimiphos-methyl" title="Pirimiphos-methyl">Pirimiphos-methyl</a></li> <li><a href="/wiki/Profenofos" title="Profenofos">Profenofos</a></li> <li><a href="/wiki/Prothoate" title="Prothoate">Prothoate</a></li> <li><a href="/wiki/R-16661" title="R-16661">R-16661</a></li> <li><a href="/w/index.php?title=Ro_3-0340&action=edit&redlink=1" class="new" title="Ro 3-0340 (page does not exist)">Ro 3-0340</a></li> <li><a href="/w/index.php?title=Ro_3-0346&action=edit&redlink=1" class="new" title="Ro 3-0346 (page does not exist)">Ro 3-0346</a></li> <li><a href="/w/index.php?title=Ro_3-0347&action=edit&redlink=1" class="new" title="Ro 3-0347 (page does not exist)">Ro 3-0347</a></li> <li><a href="/w/index.php?title=Ro_3-0351&action=edit&redlink=1" class="new" title="Ro 3-0351 (page does not exist)">Ro 3-0351</a></li> <li><a href="/w/index.php?title=Ro_3-0352&action=edit&redlink=1" class="new" title="Ro 3-0352 (page does not exist)">Ro 3-0352</a></li> <li><a href="/w/index.php?title=Ro_3-0397&action=edit&redlink=1" class="new" title="Ro 3-0397 (page does not exist)">Ro 3-0397</a></li> <li><a href="/w/index.php?title=Ro_3-0411&action=edit&redlink=1" class="new" title="Ro 3-0411 (page does not exist)">Ro 3-0411</a></li> <li><a href="/wiki/Ro_3-0412" title="Ro 3-0412">Ro 3-0412</a></li> <li><a href="/w/index.php?title=Ro_3-0417&action=edit&redlink=1" class="new" title="Ro 3-0417 (page does not exist)">Ro 3-0417</a></li> <li><a href="/wiki/Ro_3-0419" title="Ro 3-0419">Ro 3-0419</a></li> <li><a href="/wiki/Ro_3-0422" title="Ro 3-0422">Ro 3-0422</a></li> <li><a href="/w/index.php?title=Ro_3-0433&action=edit&redlink=1" class="new" title="Ro 3-0433 (page does not exist)">Ro 3-0433</a></li> <li><a href="/w/index.php?title=Ronnel&action=edit&redlink=1" class="new" title="Ronnel (page does not exist)">Ronnel</a></li> <li><a href="/wiki/Sarin" title="Sarin">Sarin (GB)</a></li> <li><a href="/wiki/Schradan" title="Schradan">Schradan</a></li> <li><a href="/wiki/Soman" title="Soman">Soman (GD)</a></li> <li><a href="/wiki/Sulfotep" title="Sulfotep">Sulfotep (TEDP)</a></li> <li><a href="/wiki/Tabun_(nerve_agent)" title="Tabun (nerve agent)">Tabun (GA)</a></li> <li><a href="/wiki/Tebupirimfos" title="Tebupirimfos">Tebupirimfos</a></li> <li><a href="/wiki/Temefos" title="Temefos">Temefos</a></li> <li><a href="/wiki/Terbufos" title="Terbufos">Terbufos</a></li> <li><a href="/wiki/Tetrachlorvinphos" title="Tetrachlorvinphos">Tetrachlorvinphos</a></li> <li><a href="/wiki/Tetraethyl_pyrophosphate" title="Tetraethyl pyrophosphate">Tetraethyl pyrophosphate (TEPP)</a></li> <li><a href="/wiki/Triazofos" title="Triazofos">Triazofos</a></li> <li><a href="/w/index.php?title=Tribufos&action=edit&redlink=1" class="new" title="Tribufos (page does not exist)">Tribufos</a></li> <li><a href="/wiki/Trichlorfon" class="mw-redirect" title="Trichlorfon">Trichlorfon</a></li> <li><a href="/wiki/Trichloronate" title="Trichloronate">Trichloronate</a></li> <li><a href="/wiki/Tricresyl_phosphate" title="Tricresyl phosphate">Tricresyl phosphate</a></li> <li><a href="/wiki/VE_(nerve_agent)" title="VE (nerve agent)">VE</a></li> <li><a href="/wiki/VG_(nerve_agent)" title="VG (nerve agent)">VG</a></li> <li><a href="/wiki/VM_(nerve_agent)" title="VM (nerve agent)">VM</a></li> <li><a href="/wiki/VP_(nerve_agent)" class="mw-redirect" title="VP (nerve agent)">VP</a></li> <li><a href="/wiki/VS_(nerve_agent)" title="VS (nerve agent)">VS</a></li> <li><a href="/wiki/VR_(nerve_agent)" title="VR (nerve agent)">VR</a></li> <li><a href="/wiki/VX_(nerve_agent)" title="VX (nerve agent)">VX</a>; Others: <a href="/wiki/Demecarium" class="mw-redirect" title="Demecarium">Demecarium</a></li> <li><a href="/wiki/Fasciculin" title="Fasciculin">Fasciculins (green mamba toxins)</a> (<a href="/w/index.php?title=Fasciculin_1&action=edit&redlink=1" class="new" title="Fasciculin 1 (page does not exist)">1</a>, <a href="/w/index.php?title=Fasciculin_2&action=edit&redlink=1" class="new" title="Fasciculin 2 (page does not exist)">2</a>, <a href="/w/index.php?title=Fasciculin_3&action=edit&redlink=1" class="new" title="Fasciculin 3 (page does not exist)">3</a>, <a href="/w/index.php?title=Fasciculin_4&action=edit&redlink=1" class="new" title="Fasciculin 4 (page does not exist)">4</a>)</li> <li><a href="/wiki/Onchidal" title="Onchidal">Onchidal</a> (<i><a href="/wiki/Onchidella_binneyi" title="Onchidella binneyi">Onchidella binneyi</a></i>)</li> <li><a href="/wiki/Methanesulfonyl_fluoride" title="Methanesulfonyl fluoride">Methanesulfonyl fluoride</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/%CE%91-Pinene" title="Α-Pinene">α-Pinene</a></li> <li><a href="/wiki/%CE%91-Viniferin" title="Α-Viniferin">α-Viniferin</a></li> <li><a href="/wiki/Affinine" title="Affinine">Affinine</a></li> <li><a href="/wiki/Affinisine" title="Affinisine">Affinisine</a></li> <li><a href="/wiki/Arisugacin_A" title="Arisugacin A">Arisugacin A</a></li> <li><a href="/wiki/Bulbocapnine" title="Bulbocapnine">Bulbocapnine</a></li> <li><a href="/wiki/Conodurine" title="Conodurine">Conodurine</a></li> <li><a href="/wiki/Coronaridine" title="Coronaridine">Coronaridine</a></li> <li><a href="/wiki/Corydaline" title="Corydaline">Corydaline</a></li> <li><a href="/wiki/Corynoline" title="Corynoline">Corynoline</a></li> <li><a href="/wiki/Crimidine" title="Crimidine">Crimidine</a></li> <li><a href="/wiki/Cyclanoline" title="Cyclanoline">Cyclanoline</a></li> <li><a href="/wiki/Cymserine" title="Cymserine">Cymserine</a></li> <li><a href="/wiki/Harmaline" title="Harmaline">Harmaline</a></li> <li><a href="/wiki/Kobophenol_A" title="Kobophenol A">Kobophenol A</a></li> <li><a href="/wiki/Lactucopicrin" title="Lactucopicrin">Lactucopicrin</a></li> <li><a href="/wiki/Lycorine" title="Lycorine">Lycorine</a></li> <li><a href="/wiki/Phosacetim" title="Phosacetim">Phosacetim</a></li> <li><a href="/wiki/Rosmarinic_acid" title="Rosmarinic acid">Rosmarinic acid</a></li> <li><a href="/wiki/Stercuronium_iodide" title="Stercuronium iodide">Stercuronium iodide</a></li> <li><a href="/wiki/Taspine" title="Taspine">Taspine</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">Tetrahydrocannabinol</a></li> <li><a href="/wiki/Ungeremine" title="Ungeremine">Ungeremine</a></li> <li><a href="/wiki/Ungiminorine" title="Ungiminorine">Ungiminorine</a></li> <li><a href="/wiki/Dimethylcarbamoyl_fluoride" title="Dimethylcarbamoyl fluoride">Dimethylcarbamoyl fluoride</a></li> <li><a href="/wiki/BW284C51" title="BW284C51">BW284C51</a></li> <li><a href="/wiki/TMTFA" title="TMTFA">TMTFA</a></li> <li><a href="/wiki/3152_CT" title="3152 CT">3152 CT</a></li></ul> <ul><li><a href="/wiki/Cholinesterase_reactivator" title="Cholinesterase reactivator">Reactivators</a>: <a href="/wiki/Asoxime_chloride" title="Asoxime chloride">Asoxime chloride</a></li> <li><a href="/w/index.php?title=Methoxime&action=edit&redlink=1" class="new" title="Methoxime (page does not exist)">Methoxime</a></li> <li><a href="/wiki/Obidoxime" title="Obidoxime">Obidoxime</a></li> <li><a href="/wiki/Pralidoxime" title="Pralidoxime">Pralidoxime</a></li> <li><a href="/wiki/Trimedoxime_bromide" title="Trimedoxime bromide">Trimedoxime bromide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Butyrylcholinesterase" title="Butyrylcholinesterase"><abbr title="Butyrylcholinesterase">BChE</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Butyrylcholinesterase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/Affinine" title="Affinine">Affinine</a></li> <li><a href="/wiki/Affinisine" title="Affinisine">Affinisine</a></li> <li><a href="/wiki/Conodurine" title="Conodurine">Conodurine</a></li> <li><a href="/wiki/Cymserine" title="Cymserine">Cymserine</a></li> <li><a href="/wiki/Ladostigil" title="Ladostigil">Ladostigil</a></li> <li><a href="/wiki/Profenamine" title="Profenamine">Profenamine (ethopropazine)</a></li> <li><a href="/wiki/Rivastigmine" title="Rivastigmine">Rivastigmine</a></li> <li><a href="/wiki/Tacrine" title="Tacrine">Tacrine</a></li> <li><a href="/w/index.php?title=ZINC-12613047&action=edit&redlink=1" class="new" title="ZINC-12613047 (page does not exist)">ZINC-12613047</a></li> <li>Many of the other AChE inhibitors listed above</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Neurotransmitter_transporter" title="Neurotransmitter transporter">Transporter</a><br /><small>(<a href="/wiki/Transporter_modulator" class="mw-redirect" title="Transporter modulator">modulators</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Choline_transporter" title="Choline transporter"><abbr title="Choline transporter">CHT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Choline transporter</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/Hemicholinium-3" title="Hemicholinium-3">Hemicholinium-3 (hemicholine)</a></li> <li><a href="/wiki/Triethylcholine" title="Triethylcholine">Triethylcholine</a></li></ul> <ul><li><b>Enhancers:</b> <a href="/wiki/Coluracetam" title="Coluracetam">Coluracetam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Vesicular_acetylcholine_transporter" title="Vesicular acetylcholine transporter"><abbr title="Vesicular acetylcholine transporter">VAChT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Vesicular acetylcholine transporter</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/Vesamicol" title="Vesamicol">Vesamicol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Neurotransmitter_release" class="mw-redirect" title="Neurotransmitter release">Release</a><br /><small>(<a href="/wiki/Release_modulator" title="Release modulator">modulators</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Release_inhibitor" class="mw-redirect" title="Release inhibitor">Inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/Synaptosomal-associated_protein_25" class="mw-redirect" title="Synaptosomal-associated protein 25"><abbr title="Synaptosomal-associated protein 25">SNAP-25</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Synaptosomal-associated protein 25</span> inactivators:</b> <a href="/wiki/Botulinum_toxin" title="Botulinum toxin">Botulinum toxin</a> (<a href="/wiki/Botulinum_toxin_A" class="mw-redirect" title="Botulinum toxin A">A</a>, <a href="/wiki/Botulinum_toxin_C" class="mw-redirect" title="Botulinum toxin C">C</a>, <a href="/wiki/Botulinum_toxin_E" class="mw-redirect" title="Botulinum toxin E">E</a>)</li></ul> <ul><li><b><a href="/wiki/Vesicle-associated_membrane_protein" title="Vesicle-associated membrane protein"><abbr title="Vesicle-associated membrane protein">VAMP</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Vesicle-associated membrane protein</span> inactivators:</b> <a href="/wiki/Botulinum_toxin" title="Botulinum toxin">Botulinum toxin</a> (<a href="/wiki/Botulinum_toxin_B" class="mw-redirect" title="Botulinum toxin B">B</a>, <a href="/wiki/Botulinum_toxin_D" class="mw-redirect" title="Botulinum toxin D">D</a>, <a href="/wiki/Botulinum_toxin_F" class="mw-redirect" title="Botulinum toxin F">F</a>, <a href="/wiki/Botulinum_toxin_G" class="mw-redirect" title="Botulinum toxin G">G</a>)</li></ul> <ul><li><b>Others:</b> <a href="/wiki/Bungarotoxin" title="Bungarotoxin">Bungarotoxins</a> (<a href="/wiki/Beta-Bungarotoxin" class="mw-redirect" title="Beta-Bungarotoxin">β-bungarotoxin</a>, <a href="/wiki/%CE%93-bungarotoxin" class="mw-redirect" title="Γ-bungarotoxin">γ-bungarotoxin</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;"><a href="/wiki/Release_enhancer" class="mw-redirect" title="Release enhancer">Enhancers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/Latrophilin" title="Latrophilin"><abbr title="Latrophilin">LPHN</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Latrophilin</span> agonists:</b> <a href="/wiki/Alpha-Latrotoxin" class="mw-redirect" title="Alpha-Latrotoxin">α-Latrotoxin</a></li></ul> <ul><li><b>Others:</b> Atracotoxins (e.g., <a href="/wiki/Robustoxin" class="mw-redirect" title="Robustoxin">robustoxin</a>, <a href="/wiki/Versutoxin" title="Versutoxin">versutoxin</a>)</li> <li><a href="/wiki/Crotoxin" title="Crotoxin">Crotoxin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></dd> <dd><a href="/wiki/Template:Muscarinic_acetylcholine_receptor_modulators" title="Template:Muscarinic acetylcholine receptor modulators">Muscarinic acetylcholine receptor modulators</a></dd> <dd><a href="/wiki/Template:Nicotinic_acetylcholine_receptor_modulators" title="Template:Nicotinic acetylcholine receptor modulators">Nicotinic acetylcholine receptor modulators</a></dd></dl> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Acetylcholinesterase&oldid=1258617513">https://en.wikipedia.org/w/index.php?title=Acetylcholinesterase&oldid=1258617513</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_7" title="Category:Genes on human chromosome 7">Genes on human chromosome 7</a></li><li><a href="/wiki/Category:Acetylcholine" 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