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href="/degree-charts/master-real-estate-development/">Real Estate Development (SM)</a></li> <li><a href="/degree-charts/interdisciplinary-doctoral-statistics/">Statistics (PhD)</a></li> <li><a href="/degree-charts/master-supply-chain-management/">Supply Chain Management (MEng and MASc)</a></li> <li><a href="/degree-charts/master-technology-policy/">Technology and Policy (SM)</a></li> <li><a href="/degree-charts/master-transportation/">Transportation (SM)</a></li> </ul> </li> <li class="active isparent"><div class="toggle-wrap clearfix"><a href="/subjects/">Subjects</a><button onclick="toggleNav(this); return false;" class="arrow-wrap open" aria-expanded="true"><span class="arrow open">Toggle Subjects</span></button></div> <ul class="nav levelone" id="/subjects/"> <li><a href="/subjects/16/">Aeronautics and Astronautics (Course 16)</a></li> <li><a href="/subjects/as/">Aerospace Studies (AS)</a></li> <li><a href="/subjects/21a/">Anthropology (Course 21A)</a></li> <li><a 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href="/subjects/2/">Mechanical Engineering (Course 2)</a></li> <li><a href="/subjects/mas/">Media Arts and Sciences (MAS)</a></li> <li><a href="/subjects/ms/">Military Science (MS)</a></li> <li><a href="/subjects/21m/">Music (Course 21M)</a></li> <li><a href="/subjects/ns/">Naval Science (NS)</a></li> <li><a href="/subjects/22/">Nuclear Science and Engineering (Course 22)</a></li> <li><a href="/subjects/8/">Physics (Course 8)</a></li> <li><a href="/subjects/17/">Political Science (Course 17)</a></li> <li><a href="/subjects/sts/">Science, Technology, and Society (STS)</a></li> <li><a href="/subjects/sp/">Special Programs</a></li> <li><a href="/subjects/scm/">Supply Chain Management (SCM)</a></li> <li><a href="/subjects/21t/">Theater Arts (21T)</a></li> <li><a href="/subjects/11/">Urban Studies and Planning (Course 11)</a></li> <li><a href="/subjects/wgs/">Women's and Gender Studies (WGS)</a></li> </ul> </li> </ul>  </div>  </div>  </div>  <div id="right-col"> <div id="content" role="main" class="widthfix"> <h1 class="page-title">Biological Engineering (Course 20)</h1> <div id="textcontainer" class="page_content"> </div> <div id="coursestextcontainer" class="page_content"> <a name="coursestext"></a><div id="sc_sccoursedescs"> <div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.001 Introduction to Professional Success and Leadership in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Fall)</span><br/><span class="courseblockhours">1-0-2 units</span> </p> <p class="courseblockdesc">Interactive introduction to the discipline of Biological Engineering through presentations by alumni practitioners, with additional panels and discussions on skills for professional development. Presentations emphasize the roles of communication through writing and speaking, building and maintaining professional networks, and interpersonal and leadership skills in building successful careers. Provides practical advice about how to prepare for job searches and graduate or professional school applications from an informed viewpoint. Prepares students for UROPs, internships, and selection of BE electives. Subject can count toward the 6-unit discovery-focused credit limit for first-year students.聽聽 </p> <p class="courseblockinstructors seemore"><span><i>L. Griffith</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.002 Introduction to Concepts in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">1-0-2 units</span> </p> <p class="courseblockdesc">Introduction to scientific advances in the field of biological engineering. Topics covered include drug discovery and delivery, applications of genetic engineering, creation and uses of biomaterials, and development of biological technology to mitigate human disease and environmental problems. Discusses each selected topic from different angles, highlighting research conducted from the nano- to macro- level to highlight the breadth of biological engineering applications. Students have the opportunity to select a topic of interest and explore that topic in more depth. Subject can count toward the 6-unit discovery-focused credit limit for first-year students. Preference given to first-year students.</p> <p class="courseblockinstructors seemore"><span><i>B. Meyer</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.005 Ethics for Engineers</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=1.082J" title="1.082[J]" class="bubblelink code" onclick="return showCourse(this, '1.082J');">1.082[J]</a>, <a href="/search/?P=2.900J" title="2.900[J]" class="bubblelink code" onclick="return showCourse(this, '2.900J');">2.900[J]</a>, <a href="/search/?P=6.9320J" title="6.9320[J]" class="bubblelink code" onclick="return showCourse(this, '6.9320J');">6.9320[J]</a>, <a href="/search/?P=6.9321" title="6.9321" class="bubblelink code" onclick="return showCourse(this, '6.9321');">6.9321</a>, <a href="/search/?P=10.01J" title="10.01[J]" class="bubblelink code" onclick="return showCourse(this, '10.01J');">10.01[J]</a>, <a href="/search/?P=16.676J" title="16.676[J]" class="bubblelink code" onclick="return showCourse(this, '16.676J');">16.676[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">2-0-7 units</span> </p> <p class="courseblockdesc">Explores how to be an ethical engineer. Students examine engineering case studies along with foundational ethical readings, and investigate which ethical approaches are best and how to apply them as engineers. Topics include justice, rights, cost-benefit analysis, safety, bias, genetic engineering, climate change, and the promise and peril of AI. Discussion-based. All sections cover the same core ethical frameworks, but some sections have a particular focus for engineering case studies, such as Computer Science or Bioengineering. Students are eligible to take any section of the course, regardless of their registered course number. The subject is taught in separate sections. For <a href="/search/?P=20.005" title="20.005" class="bubblelink code" onclick="return showCourse(this, '20.005');">20.005</a>, students additionally undertake an ethical-technical analysis of a BE-related topic of their choosing. </p> <p class="courseblockinstructors seemore"><span><i>D. Lauffenburger, P. Hansen</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.010 Introduction to Experimentation in BE</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">1-0-2 units</span> </p> <p class="courseblockdesc">Teaches students to ask research questions and use the steps in the experimental method to test hypotheses. Introduces best practices in basic data analysis and interpretation. Additional topics include exploring experimental failures, unexpected results, and troubleshooting. Goal is to prepare students for undergraduate research opportunities and laboratory-based coursework. This is a discussion-based subject and is dependent on group participation. Preference to first- and second-year students.</p> <p class="courseblockinstructors seemore"><span><i>N. Lyell</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.020 Introduction to Biological Engineering Design Using Synthetic Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-3-3 units</span> </p> <p class="courseblockdesc">Project-based introduction to the engineering of synthetic biological systems. Throughout the term, students develop projects that are responsive to real-world problems of their choosing, and whose solutions depend on biological technologies. Lectures, discussions, and studio exercises introduce components and control of prokaryotic and eukaryotic behavior; DNA synthesis, standards, and abstraction in biological engineering; and issues of human practice, including biological safety, security, ethics and ownership, sharing, and innovation. Students may have the option to continue projects for participation in the iGEM competition. Preference to first-year students.</p> <p class="courseblockinstructors seemore"><span><i>J. Buck</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.051 Introduction to NEET: Living Machines</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a>, <a href="/search/?P=3.091|5.111|5.112" onclick="return showCourse(this, '3.091|5.111|5.112');">Chemistry (GIR)</a>, and <a href="/search/?P=8.01|8.01L|8.011|8.012" onclick="return showCourse(this, '8.01|8.01L|8.011|8.012');">Physics I (GIR)</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">2-2-2 units</span> </p> <p class="courseblockdesc">Focuses on physiomimetics: transforming therapeutic strategy and development. Overview of development of therapies for complex diseases, including disease mechanisms in heterogeneous patient populations, developing therapeutic strategies, modeling these in vitro, and testing the therapies. Explores the five essential technological contributions to this process: computational systems biology, synthetic biology, immuno-engineering, microphysiological systems devices/tissue engineering, and microfluidic device engineering for in vitro models and analysis. Introduces disease modeling, patient stratification, and drug development processes, includes extensive examples from industry, and provides context for choosing a concentration track in the Living Machines thread. Weekly lectures from experts in the field supplemented with structured, short projects in each topic area. Limited to 24; preference to students in the NEET Living Machines thread.</p> <p class="courseblockinstructors seemore"><span><i>L. Griffith, M. Salek</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.054 NEET - Living Machines Research Immersion</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=20.051" title="20.051" class="bubblelink code" onclick="return showCourse(this, '20.051');">20.051</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">A structured lab research experience in a specific Living Machines track. Students identify a project in a participating research lab, on a topic related to the five tracks in the NEET Living Machines program, propose a project related to the drug development theme, and prepare interim and final presentations and reports while conducting the project. Links to industry-sponsored research projects at MIT are encouraged. Project proposal must be submitted and approved in the term prior to enrollment. Limited to students in the NEET Living Machines thread.</p> <p class="courseblockinstructors seemore"><span><i>L. Griffith, E. Alm, M. Salek</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.101 Metakaryotic Biology and Epidemiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with 20.A02</span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Introduces non-eukaryotic, "metakaryotic" cells with hollow bell-shaped nuclei that serve as the stem cells of human fetal/juvenile growth and development as well as of tumors and atherosclerotic plaques. Studies the relationship of lifetime growth and mutations of metakaryotic stem cells to age-specific death rates. Considers the biological bases of treatment protocols found to kill metakaryotic cancer stem cells <i>in vitro</i> and in human pancreatic cancers <i>in vivo</i>. </p> <p class="courseblockinstructors seemore"><span><i>W. G. Thilly</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.102 Metakaryotic Stem Cells in Carcinogenesis: Origins and Cures</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.215" title="20.215" class="bubblelink code" onclick="return showCourse(this, '20.215');">20.215</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a>, and <a href="/search/?P=3.091|5.111|5.112" onclick="return showCourse(this, '3.091|5.111|5.112');">Chemistry (GIR)</a> </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Metakaryotic stem cells of organogenesis, wound healing, and the pathogenic lesions of cancers and atherosclerotic plaques. Metakaryotic cell resistance to x-ray- and chemo-therapies. Common drug treatment protocols lethal to metakaryotic cancer stem cells <i>in vivo</i> first clinical trial against pancreatic cancer. Application of a hypermutable/mutator stem cell model to the age-specific mortality from clonal diseases, and the expected responses to metakaryocidal drugs in attempted cure and prevention of tumors or atherosclerotic plaques. Students taking <a href="/search/?P=20.215" title="20.215" class="bubblelink code" onclick="return showCourse(this, '20.215');">20.215</a> responsible for <i>de novo</i> computer modeling. </p> <p class="courseblockinstructors seemore"><span><i>E. V. Gostjeva, W. G. Thilly</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.104[J] Environmental Cancer Risks, Prevention, and Therapy</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.081J" title="1.081[J]" class="bubblelink code" onclick="return showCourse(this, '1.081J');">1.081[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a>, and <a href="/search/?P=3.091|5.111|5.112" onclick="return showCourse(this, '3.091|5.111|5.112');">Chemistry (GIR)</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Analysis of the history of cancer and vascular disease mortality rates in predominantly European- and African-American US cohorts, 1895-2016, to discover specific historical shifts. Explored in terms of contemporaneously changing environmental risk factors: air-, food- and water-borne chemicals; subclinical infections; diet and lifestyles. Special section on occupational risk factors. Considers the hypotheses that genetic and/or environmental factors affect metakaryotic stem cell mutation rates in fetuses and juveniles and/or their growth rates of preneoplastic in adults. </p> <p class="courseblockinstructors seemore"><span><i>W. Thilly, R. McCunney</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.106[J] Applied Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.084J" title="1.084[J]" class="bubblelink code" onclick="return showCourse(this, '1.084J');">1.084[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> and <a href="/search/?P=3.091|5.111|5.112" onclick="return showCourse(this, '3.091|5.111|5.112');">Chemistry (GIR)</a> </span><br/><span class="courseblockterms">U (Fall)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Introductory microbiology from a systems perspective - considers microbial diversity and the integration of data from a molecular, cellular, organismal, and ecological context to understand the interaction of microbial organisms with their environment. Special emphasis on specific viral, bacterial, and eukaryotic microorganisms and their interaction with animal hosts with focus on contemporary problems in areas such as vaccination, emerging disease, antimicrobial drug resistance, and toxicology. </p> <p class="courseblockinstructors seemore"><span><i>J. C. Niles, K. Ribbeck</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.109 Laboratory Fundamentals in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=3.091|5.111|5.112" onclick="return showCourse(this, '3.091|5.111|5.112');">Chemistry (GIR)</a>, <a href="/search/?P=6.100B" title="6.100B" class="bubblelink code" onclick="return showCourse(this, '6.100B');">6.100B</a>, <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a>, and <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">2-8-5 units. Institute LAB</span> </p> <p class="courseblockdesc">Introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. In this, students complete discovery-based experimental modules drawn from current technologies and active research projects of BE faculty. Generally, topics include DNA engineering, in which students design, construct, and use genetic material; parts engineering, emphasizing protein design and quantitative assessment of protein performance; systems engineering, which considers genome-wide consequences of genetic perturbations; and biomaterials engineering, in which students use biologically-encoded devices to design and build materials. Enrollment limited; priority to Course 20 majors.</p> <p class="courseblockinstructors seemore"><span><i>N. Lyell,聽A. Koehler, B.聽Engelward, L. McClain,聽B. Meyer,聽S. Clarke, P. Bhargava</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.110[J] Thermodynamics of Biomolecular Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.772J" title="2.772[J]" class="bubblelink code" onclick="return showCourse(this, '2.772J');">2.772[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a>, <a href="/search/?P=3.091|5.111|5.112" onclick="return showCourse(this, '3.091|5.111|5.112');">Chemistry (GIR)</a>, and <a href="/search/?P=8.01|8.01L|8.011|8.012" onclick="return showCourse(this, '8.01|8.01L|8.011|8.012');">Physics I (GIR)</a>) or permission of instructor </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">5-0-7 units. REST</span> </p> <p class="courseblockdesc">Equilibrium properties of macroscopic and microscopic systems. Basic thermodynamics: state of a system, state variables. Work, heat, first law of thermodynamics, thermochemistry. Second and third law of thermodynamics: entropy and its statistical basis, Gibbs function. Chemical equilibrium of reactions in gas and solution phase. Macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding cooperativity, solvation, titration of macromolecules. </p> <p class="courseblockinstructors seemore"><span><i>M. Birnbaum, C. Voigt</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.129[J] Biological Circuit Engineering Laboratory</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=6.4880J" title="6.4880[J]" class="bubblelink code" onclick="return showCourse(this, '6.4880J');">6.4880[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> and <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">2-8-2 units. Institute LAB</span> </p> <p class="courseblockdesc">Students assemble individual genes and regulatory elements into larger-scale circuits; they experimentally characterize these circuits in yeast cells using quantitative techniques, including flow cytometry, and model their results computationally. Emphasizes concepts and techniques to perform independent experimental and computational synthetic biology research. Discusses current literature and ongoing research in the field of synthetic biology. Instruction and practice in oral and written communication provided. Enrollment limited.</p> <p class="courseblockinstructors seemore"><span><i>T. Lu, R. Weiss</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.200 Biological Engineering Seminar</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">1-0-2 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Weekly one-hour seminars covering graduate student research and presentations by invited speakers. </p> <p class="courseblockinstructors seemore"><span><i>B. Engelward</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.201 Fundamentals of Drug Development</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Team-based exploration of the scientific basis for developing new drugs. First portion of term covers fundamentals of target identification, drug discovery, pharmacokinetics, pharmacodynamics, regulatory policy, and intellectual property. Industry experts and academic entrepreneurs then present case studies of specific drugs, drug classes, and therapeutic targets. In a term-long project, student teams develop novel therapeutics to solve major unmet medical needs, with a trajectory to a "start-up" company. Culminates with team presentations to a panel of industry and scientific leaders. </p> <p class="courseblockinstructors seemore"><span><i>P. C. Dedon, R. Sasisekharan</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.202 In vivo Models: Principles and Practices</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">1-1-4 units</span> </p> <p class="courseblockdesc">Selected aspects of anatomy, histology, immuno-cytochemistry, in situ hybridization, physiology, and cell biology of mammalian organisms and their pathogens. Subject material integrated with principles of toxicology, in vivo genetic engineering, and molecular biology. A lab/demonstration period each week involves experiments in anatomy (in vivo), physiology, and microscopy to augment the lectures. Offered first half of spring term. </p> <p class="courseblockinstructors seemore"><span><i>J. G. Fox, B. Marini, M. Whary</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.203[J] Neurotechnology in Action</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.123J" title="9.123[J]" class="bubblelink code" onclick="return showCourse(this, '9.123J');">9.123[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-6-3 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=9.123J" title="9.123[J]" class="bubblelink code" onclick="return showCourse(this, '9.123J');">9.123[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>A. Jasanoff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.205[J] Principles and Applications of Genetic Engineering for Biotechnology and Neuroscience</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.26J" title="9.26[J]" class="bubblelink code" onclick="return showCourse(this, '9.26J');">9.26[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=9.26J" title="9.26[J]" class="bubblelink code" onclick="return showCourse(this, '9.26J');">9.26[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>F. Zhang</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.213 Genome Stability and Engineering in the Context of Diseases, Drugs, and Public Health</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a>, <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>, or permission of instructor </span><br/><span class="courseblockterms">U (Spring; second half of term)</span><br/><span class="courseblockhours">4-0-5 units</span> </p> <p class="courseblockdesc">Studies how DNA damage leads to diseases, and how DNA repair modulates cancer risk and treatment. Also covers how DNA repair impacts genetic engineering, whether by targeted gene therapy or CRISPR-mediated genetic changes. Students gain a public health perspective by examining how DNA-damaging agents in our environment can lead to downstream cancer. Explores the underlying chemical, molecular and biochemical processes of DNA damage and repair, and their implications for disease susceptibility and treatment. </p> <p class="courseblockinstructors seemore"><span><i>B. P. Engelward</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.215 Macroepidemiology, Population Genetics, and Stem Cell Biology of Human Clonal Diseases</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.102" title="20.102" class="bubblelink code" onclick="return showCourse(this, '20.102');">20.102</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a> and <a href="/search/?P=1.00" title="1.00" class="bubblelink code" onclick="return showCourse(this, '1.00');">1.00</a> </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-15 units</span> </p> <p class="courseblockdesc">Studies the logic and technology needed to discover genetic and environmental risks for common human cancers and vascular diseases. Includes an introduction to metakaryotic stem cell biology. Analyzes large, organized historical public health databases using quantitative cascade computer models that include population stratification of stem cell mutation rates in fetal/juvenile tissues and growth rates in preneoplastic colonies and atherosclerotic plaques. Means to test hypotheses (CAST) that certain genes carry mutations conferring risk for common cancers via genetic analyses in large human cohorts. Involves de novo computer modeling of a lifetime disease experience or test of a student-developed hypothesis. </p> <p class="courseblockinstructors seemore"><span><i>W. G. Thilly</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.219 Selected Topics in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.230[J] Immunology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.23J" title="7.23[J]" class="bubblelink code" onclick="return showCourse(this, '7.23J');">7.23[J]</a><br/> Subject meets with <a href="/search/?P=7.63J" title="7.63[J]" class="bubblelink code" onclick="return showCourse(this, '7.63J');">7.63[J]</a>, <a href="/search/?P=20.630J" title="20.630[J]" class="bubblelink code" onclick="return showCourse(this, '20.630J');">20.630[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=7.23J" title="7.23[J]" class="bubblelink code" onclick="return showCourse(this, '7.23J');">7.23[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>S. Spranger, M. Birnbaum</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.260 Computational Analysis of Biological Data</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.460" title="20.460" class="bubblelink code" onclick="return showCourse(this, '20.460');">20.460</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=6.100A" title="6.100A" class="bubblelink code" onclick="return showCourse(this, '6.100A');">6.100A</a> or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Presents foundational methods for analysis of complex biological datasets. Covers fundamental concepts in probability, statistics, and linear algebra underlying computational tools that enable generation of biological insights. Assignments focus on practical examples spanning basic science and medical applications. Assumes basic knowledge of calculus and programming (experience with MATLAB, Python, or R is recommended). Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Lauffenburger, F. White</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.265 Genetics for Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=6.100A" title="6.100A" class="bubblelink code" onclick="return showCourse(this, '6.100A');">6.100A</a> or permission of instructor </span><br/><span class="courseblockterms">U (Spring; second half of term)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-3 units</span> </p> <p class="courseblockdesc">Covers topics in genetics from an engineering perspective. Designed to be taken before, concurrently with, or after a traditional genetics class. Focuses primarily on the quantitative methods and algorithms used in genetics and genomics. Provides a strong foundation in genomics and bioinformatics and prepares students, through real-world problem-solving, for upper-level classes in those topics. Basics of modern genomics tools and approaches -- including RNAseq, high-throughout genome sequencing, genome-wide association studies, metagenomics, and others -- presented. Requires some experience with Python programming. </p> <p class="courseblockinstructors seemore"><span><i>E. Alm</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.305[J] Principles of Synthetic Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=6.8721J" title="6.8721[J]" class="bubblelink code" onclick="return showCourse(this, '6.8721J');">6.8721[J]</a><br/> Subject meets with <a href="/search/?P=6.8720J" title="6.8720[J]" class="bubblelink code" onclick="return showCourse(this, '6.8720J');">6.8720[J]</a>, <a href="/search/?P=20.405J" title="20.405[J]" class="bubblelink code" onclick="return showCourse(this, '20.405J');">20.405[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Introduces the basics of synthetic biology, including quantitative cellular network characterization and modeling. Considers the discovery and genetic factoring of useful cellular activities into reusable functions for design. Emphasizes the principles of biomolecular system design and diagnosis of designed systems. Illustrates cutting-edge applications in synthetic biology and enhances skills in analysis and design of synthetic biological applications. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>R. Weiss</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.309[J] Instrumentation and Measurement for Biological Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.673J" title="2.673[J]" class="bubblelink code" onclick="return showCourse(this, '2.673J');">2.673[J]</a><br/> Subject meets with <a href="/search/?P=20.409" title="20.409" class="bubblelink code" onclick="return showCourse(this, '20.409');">20.409</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=8.02|8.021|8.022" onclick="return showCourse(this, '8.02|8.021|8.022');">Physics II (GIR)</a>, <a href="/search/?P=6.100B" title="6.100B" class="bubblelink code" onclick="return showCourse(this, '6.100B');">6.100B</a>, and <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a>) or permission of instructor </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">3-6-3 units</span> </p> <p class="courseblockdesc">Sensing and measurement aimed at quantitative molecular/cell/tissue analysis in terms of genetic, biochemical, and biophysical properties. Methods include light and fluorescence microscopies, and electro-mechanical probes (atomic force microscopy, optical traps, MEMS devices). Application of statistics, probability, signal and noise analysis, and Fourier techniques to experimental data. Enrollment limited; preference to Course 20 undergraduates.</p> <p class="courseblockinstructors seemore"><span><i>P. Blainey, S. Manalis, E. Frank, S. Wasserman, J. Bagnall, E. Boyden, P. So</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.310[J] Molecular, Cellular, and Tissue Biomechanics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.797J" title="2.797[J]" class="bubblelink code" onclick="return showCourse(this, '2.797J');">2.797[J]</a>, <a href="/search/?P=3.053J" title="3.053[J]" class="bubblelink code" onclick="return showCourse(this, '3.053J');">3.053[J]</a>, <a href="/search/?P=6.4840J" title="6.4840[J]" class="bubblelink code" onclick="return showCourse(this, '6.4840J');">6.4840[J]</a><br/> Subject meets with <a href="/search/?P=2.798J" title="2.798[J]" class="bubblelink code" onclick="return showCourse(this, '2.798J');">2.798[J]</a>, <a href="/search/?P=3.971J" title="3.971[J]" class="bubblelink code" onclick="return showCourse(this, '3.971J');">3.971[J]</a>, <a href="/search/?P=6.4842J" title="6.4842[J]" class="bubblelink code" onclick="return showCourse(this, '6.4842J');">6.4842[J]</a>, <a href="/search/?P=10.537J" title="10.537[J]" class="bubblelink code" onclick="return showCourse(this, '10.537J');">10.537[J]</a>, <a href="/search/?P=20.410J" title="20.410[J]" class="bubblelink code" onclick="return showCourse(this, '20.410J');">20.410[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> and <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>M. Bathe, K. Ribbeck, P. T. So</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.315 Physical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.415" title="20.415" class="bubblelink code" onclick="return showCourse(this, '20.415');">20.415</a></span><br/><span class="courseblockprereq">Prereq: 5.60, <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a>, or permission of instructor </span><br/><span class="courseblockterms">U (Fall, Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-9 units</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=8.241" title="8.241" class="bubblelink code" onclick="return showCourse(this, '8.241');">8.241</a></span> </p> <p class="courseblockdesc">Focuses on current major research topics in quantitative, physical biology. Covers synthetic structural biology, synthetic cell biology, microbial systems biology and evolution, cellular decision making, neuronal circuits, and development and morphogenesis. Emphasizes current motivation and historical background, state-of-the-art measurement methodologies and techniques, and quantitative physical modeling frameworks. Experimental techniques include structural biology, next-generation sequencing, fluorescence imaging and spectroscopy, and quantitative biochemistry. Modeling approaches include stochastic rate equations, statistical thermodynamics, and statistical inference. Students taking graduate version complete additional assignments. <a href="/search/?P=20.315" title="20.315" class="bubblelink code" onclick="return showCourse(this, '20.315');">20.315</a> and <a href="/search/?P=20.415" title="20.415" class="bubblelink code" onclick="return showCourse(this, '20.415');">20.415</a> meet with <a href="/search/?P=8.241" title="8.241" class="bubblelink code" onclick="return showCourse(this, '8.241');">8.241</a> when offered concurrently. </p> <p class="courseblockinstructors seemore"><span><i>J. Gore, I. Cisse</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.320 Analysis of Biomolecular and Cellular Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=6.100B" title="6.100B" class="bubblelink code" onclick="return showCourse(this, '6.100B');">6.100B</a>, <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a>, and <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a>; <i>Coreq: <a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a> or <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a></i> </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Analysis of molecular and cellular processes across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis on experimental methods, quantitative analysis, and computational modeling. </p> <p class="courseblockinstructors seemore"><span><i>F. White, K. D. Wittrup</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.330[J] Fields, Forces and Flows in Biological Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.793J" title="2.793[J]" class="bubblelink code" onclick="return showCourse(this, '2.793J');">2.793[J]</a>, <a href="/search/?P=6.4830J" title="6.4830[J]" class="bubblelink code" onclick="return showCourse(this, '6.4830J');">6.4830[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a>, <a href="/search/?P=8.02|8.021|8.022" onclick="return showCourse(this, '8.02|8.021|8.022');">Physics II (GIR)</a>, and <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Introduction to electric fields, fluid flows, transport phenomena and their application to biological systems. Flux and continuity laws, Maxwell's equations, electro-quasistatics, electro-chemical-mechanical driving forces, conservation of mass and momentum, Navier-Stokes flows, and electrokinetics. Applications include biomolecular transport in tissues, electrophoresis, and microfluidics. </p> <p class="courseblockinstructors seemore"><span><i>J. Han, S. Manalis</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.334 Biological Systems Modeling</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=20.330" title="20.330[J]" class="bubblelink code" onclick="return showCourse(this, '20.330');">20.330[J]</a> or permission of instructor </span><br/><span class="courseblockterms">U (Fall; first half of term)</span><br/><span class="courseblockhours">1-0-5 units</span> </p> <p class="courseblockdesc">Practices the use of modern numerical analysis tools (e.g., COMSOL) for biological systems with multi-physics behavior. Covers modeling of diffusion, reaction, convection and other transport mechanisms. Analysis of microfluidic devices as examples. Discusses practical issues and challenges in numerical modeling. No prior knowledge of modeling software required. Includes weekly modeling homework and one final modeling project. </p> <p class="courseblockinstructors seemore"><span><i>J. Han</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.345 Bioinstrumentation Project Lab</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=20.309" title="20.309[J]" class="bubblelink code" onclick="return showCourse(this, '20.309');">20.309[J]</a>, (<a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> and (<a href="/search/?P=2.004" title="2.004" class="bubblelink code" onclick="return showCourse(this, '2.004');">2.004</a> or <a href="/search/?P=6.3000" title="6.3000" class="bubblelink code" onclick="return showCourse(this, '6.3000');">6.3000</a>)), or permission of instructor </span><br/><span class="courseblockterms">U (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">2-7-3 units</span> </p> <p class="courseblockdesc">In-depth examination of instrumentation design, principles and techniques for studying biological systems, from single molecules to entire organisms. Lectures cover optics, advanced microscopy techniques, electronics for biological measurement, magnetic resonance imaging, computed tomography, MEMs, microfluidic devices, and limits of detection. Students select two lab exercises during the first half of the semester and complete a final design project in the second half. Lab emphasizes design process and skillful realization of a robust system. Enrollment limited; preference to Course 20 majors and minors.</p> <p class="courseblockinstructors seemore"><span><i>E. Boyden, M. Jonas, P. So, S. Wasserman</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.352 Principles of Neuroengineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=9.422J" title="9.422[J]" class="bubblelink code" onclick="return showCourse(this, '9.422J');">9.422[J]</a>, <a href="/search/?P=20.452J" title="20.452[J]" class="bubblelink code" onclick="return showCourse(this, '20.452J');">20.452[J]</a>, <a href="/search/?P=MAS.881J" title="MAS.881[J]" class="bubblelink code" onclick="return showCourse(this, 'MAS.881J');">MAS.881[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Covers how to innovate technologies for brain analysis and engineering, for accelerating the basic understanding of the brain, and leading to new therapeutic insight and inventions. Focuses on using physical, chemical and biological principles to understand technology design criteria governing ability to observe and alter brain structure and function. Topics include optogenetics, noninvasive brain imaging and stimulation, nanotechnologies, stem cells and tissue engineering, and advanced molecular and structural imaging technologies. Includes design projects. Students taking graduate version complete additional assignments. Designed for students with engineering maturity who are ready for design. </p> <p class="courseblockinstructors seemore"><span><i>E. S. Boyden, III</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.361[J] Molecular and Engineering Aspects of Biotechnology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.37J" title="7.37[J]" class="bubblelink code" onclick="return showCourse(this, '7.37J');">7.37[J]</a>, <a href="/search/?P=10.441J" title="10.441[J]" class="bubblelink code" onclick="return showCourse(this, '10.441J');">10.441[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> and (<a href="/search/?P=2.005" title="2.005" class="bubblelink code" onclick="return showCourse(this, '2.005');">2.005</a>, 3.012, 5.60, or <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a>)) or permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: U (Spring)</span><br/><span class="courseblockhours">4-0-8 units</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.371" title="7.371" class="bubblelink code" onclick="return showCourse(this, '7.371');">7.371</a></span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=7.37J" title="7.37[J]" class="bubblelink code" onclick="return showCourse(this, '7.37J');">7.37[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.363[J] Biomaterials Science and Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=3.055J" title="3.055[J]" class="bubblelink code" onclick="return showCourse(this, '3.055J');">3.055[J]</a><br/> Subject meets with <a href="/search/?P=3.963J" title="3.963[J]" class="bubblelink code" onclick="return showCourse(this, '3.963J');">3.963[J]</a>, <a href="/search/?P=20.463J" title="20.463[J]" class="bubblelink code" onclick="return showCourse(this, '20.463J');">20.463[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a> or permission of instructor </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Covers, at a molecular scale, the analysis and design of materials used in contact with biological systems, and biomimetic strategies aimed at creating new materials based on principles found in biology. Topics include molecular interaction between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Irvine, K. Ribbeck</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.365 Engineering the Immune System in Cancer and Beyond</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.465" title="20.465" class="bubblelink code" onclick="return showCourse(this, '20.465');">20.465</a></span><br/><span class="courseblockprereq">Prereq: (5.60 or <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a>) and permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Examines strategies in clinical and preclinical development for manipulating the immune system to treat and protect against disease. Begins with brief review of immune system. Discusses interaction of tumors with the immune system, followed by approaches by which the immune system can be modulated to attack cancer. Also covers strategies based in biotechnology, chemistry, materials science, and molecular biology to induce immune responses to treat infection, transplantation, and autoimmunity. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Irvine</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.370[J] Cellular Neurophysiology and Computing</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.791J" title="2.791[J]" class="bubblelink code" onclick="return showCourse(this, '2.791J');">2.791[J]</a>, <a href="/search/?P=6.4810J" title="6.4810[J]" class="bubblelink code" onclick="return showCourse(this, '6.4810J');">6.4810[J]</a>, <a href="/search/?P=9.21J" title="9.21[J]" class="bubblelink code" onclick="return showCourse(this, '9.21J');">9.21[J]</a><br/> Subject meets with <a href="/search/?P=2.794J" title="2.794[J]" class="bubblelink code" onclick="return showCourse(this, '2.794J');">2.794[J]</a>, <a href="/search/?P=6.4812J" title="6.4812[J]" class="bubblelink code" onclick="return showCourse(this, '6.4812J');">6.4812[J]</a>, <a href="/search/?P=9.021J" title="9.021[J]" class="bubblelink code" onclick="return showCourse(this, '9.021J');">9.021[J]</a>, <a href="/search/?P=20.470J" title="20.470[J]" class="bubblelink code" onclick="return showCourse(this, '20.470J');">20.470[J]</a>, <a href="/search/?P=HST.541J" title="HST.541[J]" class="bubblelink code" onclick="return showCourse(this, 'HST.541J');">HST.541[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=8.02|8.021|8.022" onclick="return showCourse(this, '8.02|8.021|8.022');">Physics II (GIR)</a>, <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a>, and (<a href="/search/?P=2.005" title="2.005" class="bubblelink code" onclick="return showCourse(this, '2.005');">2.005</a>, <a href="/search/?P=6.2000" title="6.2000" class="bubblelink code" onclick="return showCourse(this, '6.2000');">6.2000</a>, <a href="/search/?P=6.3000" title="6.3000" class="bubblelink code" onclick="return showCourse(this, '6.3000');">6.3000</a>, <a href="/search/?P=10.301" title="10.301" class="bubblelink code" onclick="return showCourse(this, '10.301');">10.301</a>, or <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a>)) or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">5-2-5 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=6.4810J" title="6.4810[J]" class="bubblelink code" onclick="return showCourse(this, '6.4810J');">6.4810[J]</a>. Preference to juniors and seniors.</p> <p class="courseblockinstructors seemore"><span><i>J. Han, T. Heldt</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.373 Foundations of Cell Therapy Manufacturing</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.473" title="20.473" class="bubblelink code" onclick="return showCourse(this, '20.473');">20.473</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Seminar examines cell therapy manufacturing, the ex vivo production of human cells to be delivered to humans as a product for medical benefit. Includes a review of cell biology and immunology. Addresses topics such as governmental regulations applying to cell therapy production; the manufacture of cell-based therapeutics, including cell culture unit operations, genetic engineering or editing of cells; process engineering of cell therapy products; and the analytics of cell therapy manufacturing processes. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>K. Van Vliet</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.375 Applied Developmental Biology and Tissue Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.475" title="20.475" class="bubblelink code" onclick="return showCourse(this, '20.475');">20.475</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a>, <a href="/search/?P=20.320" title="20.320" class="bubblelink code" onclick="return showCourse(this, '20.320');">20.320</a>, and (<a href="/search/?P=7.003" title="7.003[J]" class="bubblelink code" onclick="return showCourse(this, '7.003');">7.003[J]</a> or <a href="/search/?P=20.109" title="20.109" class="bubblelink code" onclick="return showCourse(this, '20.109');">20.109</a>)) or permission of instructor </span><br/><span class="courseblockterms">U (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Addresses the integration of engineering and biology design principles to create human tissues and organs for regenerative medicine to drug development. Provides an overview of embryogenesis, how morphogenic phenomena are governed by biochemical and biophysical cues. Analyzes <em>in vitro</em> generation of human brain, gut, and other organoids from stem cells. Studies the roles of biomaterials and microreactors in improving organoid formation and function; organoid use in modeling disease and physiology <em>in vitro</em>; and engineering and biological principles of reconstructing tissues and organs from postnatal donor cells using biomaterials scaffolds and bioreactors. Includes select applications, such as liver disease, brain disorders, and others. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>L. Griffith</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.380 Biological Engineering Design</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a>, <a href="/search/?P=20.320" title="20.320" class="bubblelink code" onclick="return showCourse(this, '20.320');">20.320</a>, and <a href="/search/?P=20.330" title="20.330[J]" class="bubblelink code" onclick="return showCourse(this, '20.330');">20.330[J]</a> </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">Illustrates how knowledge and principles of biology, biochemistry, and engineering are integrated to create new products for societal benefit. Uses case study format to examine recently developed products of pharmaceutical and biotechnology industries: how a product evolves from initial idea, through patents, testing, evaluation, production, and marketing. Emphasizes scientific and engineering principles, as well as the responsibility scientists, engineers, and business executives have for the consequences of their technology. Instruction and practice in written and oral communication provided. Enrollment limited; preference to Course 20 undergraduates.</p> <p class="courseblockinstructors seemore"><span><i>J. Collins, A. Koehler, J. Essigmann, K. Ribbeck</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.381 Biological Engineering Design II</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=20.380" title="20.380" class="bubblelink code" onclick="return showCourse(this, '20.380');">20.380</a> or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">0-12-0 units</span> </p> <p class="courseblockdesc">Continuation of <a href="/search/?P=20.380" title="20.380" class="bubblelink code" onclick="return showCourse(this, '20.380');">20.380</a> that focuses on practical聽implementation of design proposals. Student teams choose a feasible聽scope of work related to their <a href="/search/?P=20.380" title="20.380" class="bubblelink code" onclick="return showCourse(this, '20.380');">20.380</a> design proposals and聽execute it in the聽lab. </p> <p class="courseblockinstructors seemore"><span><i>M. Jonas, J. Sutton, S. Wasserman</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.385 Design in Synthetic Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: (<a href="/search/?P=20.020" title="20.020" class="bubblelink code" onclick="return showCourse(this, '20.020');">20.020</a>, <a href="/search/?P=20.109" title="20.109" class="bubblelink code" onclick="return showCourse(this, '20.109');">20.109</a>, and <a href="/search/?P=20.320" title="20.320" class="bubblelink code" onclick="return showCourse(this, '20.320');">20.320</a>) or permission of instructor </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">3-3-3 units</span> </p> <p class="courseblockdesc">Provides an understanding of the state of research in synthetic biology and development of project management skills. Critical evaluation of primary research literature covering a range of approaches to the design, modeling and programming of cellular behaviors. Focuses on developing the skills needed to read, present and discuss primary research literature, and to manage and lead small teams. Students mentor a small undergraduate team of <a href="/search/?P=20.020" title="20.020" class="bubblelink code" onclick="return showCourse(this, '20.020');">20.020</a> students. Open to advanced students with appropriate background in biology. Students may have the option to continue projects for participation in the iGEM competition. </p> <p class="courseblockinstructors seemore"><span><i>J. Buck</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.390[J] Computational Systems Biology: Deep Learning in the Life Sciences</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=6.8711J" title="6.8711[J]" class="bubblelink code" onclick="return showCourse(this, '6.8711J');">6.8711[J]</a><br/> Subject meets with <a href="/search/?P=6.8710J" title="6.8710[J]" class="bubblelink code" onclick="return showCourse(this, '6.8710J');">6.8710[J]</a>, <a href="/search/?P=20.490" title="20.490" class="bubblelink code" onclick="return showCourse(this, '20.490');">20.490</a>, <a href="/search/?P=HST.506J" title="HST.506[J]" class="bubblelink code" onclick="return showCourse(this, 'HST.506J');">HST.506[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=6.100B" title="6.100B" class="bubblelink code" onclick="return showCourse(this, '6.100B');">6.100B</a> and <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>) or permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: U (Spring)<br/> Acad Year 2025-2026: Not offered</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=6.8711J" title="6.8711[J]" class="bubblelink code" onclick="return showCourse(this, '6.8711J');">6.8711[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>D. K. Gifford</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.405[J] Principles of Synthetic Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=6.8720J" title="6.8720[J]" class="bubblelink code" onclick="return showCourse(this, '6.8720J');">6.8720[J]</a><br/> Subject meets with <a href="/search/?P=6.8721J" title="6.8721[J]" class="bubblelink code" onclick="return showCourse(this, '6.8721J');">6.8721[J]</a>, <a href="/search/?P=20.305J" title="20.305[J]" class="bubblelink code" onclick="return showCourse(this, '20.305J');">20.305[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Introduces the basics of synthetic biology, including quantitative cellular network characterization and modeling. Considers the discovery and genetic factoring of useful cellular activities into reusable functions for design. Emphasizes the principles of biomolecular system design and diagnosis of designed systems. Illustrates cutting-edge applications in synthetic biology and enhances skills in analysis and design of synthetic biological applications. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>R. Weiss</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.409 Biological Engineering II: Instrumentation and Measurement</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=2.673J" title="2.673[J]" class="bubblelink code" onclick="return showCourse(this, '2.673J');">2.673[J]</a>, <a href="/search/?P=20.309J" title="20.309[J]" class="bubblelink code" onclick="return showCourse(this, '20.309J');">20.309[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">2-7-3 units</span> </p> <p class="courseblockdesc">Sensing and measurement aimed at quantitative molecular/cell/tissue analysis in terms of genetic, biochemical, and biophysical properties. Methods include light and fluorescence microscopies, electronic circuits, and electro-mechanical probes (atomic force microscopy, optical traps, MEMS devices). Application of statistics, probability, signal and noise analysis, and Fourier techniques to experimental data. Limited to 5 graduate students.</p> <p class="courseblockinstructors seemore"><span><i>P. Blainey, S. Manalis, S. Wasserman, J. Bagnall, E. Frank, E. Boyden, P. So</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.410[J] Molecular, Cellular, and Tissue Biomechanics</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.798J" title="2.798[J]" class="bubblelink code" onclick="return showCourse(this, '2.798J');">2.798[J]</a>, <a href="/search/?P=3.971J" title="3.971[J]" class="bubblelink code" onclick="return showCourse(this, '3.971J');">3.971[J]</a>, <a href="/search/?P=6.4842J" title="6.4842[J]" class="bubblelink code" onclick="return showCourse(this, '6.4842J');">6.4842[J]</a>, <a href="/search/?P=10.537J" title="10.537[J]" class="bubblelink code" onclick="return showCourse(this, '10.537J');">10.537[J]</a><br/> Subject meets with <a href="/search/?P=2.797J" title="2.797[J]" class="bubblelink code" onclick="return showCourse(this, '2.797J');">2.797[J]</a>, <a href="/search/?P=3.053J" title="3.053[J]" class="bubblelink code" onclick="return showCourse(this, '3.053J');">3.053[J]</a>, <a href="/search/?P=6.4840J" title="6.4840[J]" class="bubblelink code" onclick="return showCourse(this, '6.4840J');">6.4840[J]</a>, <a href="/search/?P=20.310J" title="20.310[J]" class="bubblelink code" onclick="return showCourse(this, '20.310J');">20.310[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> and <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a> </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>M. Bathe, K. Ribbeck, P. T. So</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.415 Physical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.315" title="20.315" class="bubblelink code" onclick="return showCourse(this, '20.315');">20.315</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-9 units</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=8.241" title="8.241" class="bubblelink code" onclick="return showCourse(this, '8.241');">8.241</a></span> </p> <p class="courseblockdesc">Focuses on current major research topics in quantitative, physical biology. Topics include synthetic structural biology, synthetic cell biology, microbial systems biology and evolution, cellular decision making, neuronal circuits, and development and morphogenesis. Emphasizes current motivation and historical background, state-of-the-art measurement methodologies and techniques, and quantitative physical modeling frameworks. Experimental techniques include structural biology, next-generation sequencing, fluorescence imaging and spectroscopy, and quantitative biochemistry. Modeling approaches include stochastic rate equations, statistical thermodynamics, and statistical inference. Students taking graduate version complete additional assignments. <a href="/search/?P=20.315" title="20.315" class="bubblelink code" onclick="return showCourse(this, '20.315');">20.315</a> and <a href="/search/?P=20.415" title="20.415" class="bubblelink code" onclick="return showCourse(this, '20.415');">20.415</a> meet with <a href="/search/?P=8.241" title="8.241" class="bubblelink code" onclick="return showCourse(this, '8.241');">8.241</a> when offered concurrently. </p> <p class="courseblockinstructors seemore"><span><i>J. Gore, I. Cisse</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.416[J] Topics in Biophysics and Physical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.74J" title="7.74[J]" class="bubblelink code" onclick="return showCourse(this, '7.74J');">7.74[J]</a>, <a href="/search/?P=8.590J" title="8.590[J]" class="bubblelink code" onclick="return showCourse(this, '8.590J');">8.590[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=8.590J" title="8.590[J]" class="bubblelink code" onclick="return showCourse(this, '8.590J');">8.590[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>J. Gore, N. Fakhri</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.420[J] Principles of Molecular Bioengineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=10.538J" title="10.538[J]" class="bubblelink code" onclick="return showCourse(this, '10.538J');">10.538[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> and <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a> </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Provides an introduction to the mechanistic analysis and engineering of biomolecules and biomolecular systems. Covers methods for measuring, modeling, and manipulating systems, including biophysical experimental tools, computational modeling approaches, and molecular design. Equips students to take systematic and quantitative approaches to the investigation of a wide variety of biological phenomena. </p> <p class="courseblockinstructors seemore"><span><i>A. Jasanoff, E. Fraenkel</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.430[J] Fields, Forces, and Flows in Biological Systems</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.795J" title="2.795[J]" class="bubblelink code" onclick="return showCourse(this, '2.795J');">2.795[J]</a>, <a href="/search/?P=6.4832J" title="6.4832[J]" class="bubblelink code" onclick="return showCourse(this, '6.4832J');">6.4832[J]</a>, <a href="/search/?P=10.539J" title="10.539[J]" class="bubblelink code" onclick="return showCourse(this, '10.539J');">10.539[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Molecular diffusion, diffusion-reaction, conduction, convection in biological systems; fields in heterogeneous media; electrical double layers; Maxwell stress tensor, electrical forces in physiological systems. Fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies of membrane transport, electrode interfaces, electrical, mechanical, and chemical transduction in tissues, convective-diffusion/reaction, electrophoretic, electroosmotic flows in tissues/MEMs, and ECG. Electromechanical and physicochemical interactions in cells and biomaterials; musculoskeletal, cardiovascular, and other biological and clinical examples. Prior undergraduate coursework in transport recommended. </p> <p class="courseblockinstructors seemore"><span><i>M. Bathe, A. J. Grodzinsky</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.440 Analysis of Biological Networks</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: <a href="/search/?P=20.420" title="20.420[J]" class="bubblelink code" onclick="return showCourse(this, '20.420');">20.420[J]</a> and permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">6-0-9 units</span> </p> <p class="courseblockdesc">Explores computational and experimental approaches to analyzing complex biological networks and systems. Includes genomics, transcriptomics, proteomics, metabolomics and microscopy. Stresses the practical considerations required when designing and performing experiments. Also focuses on selection and implementation of appropriate computational tools for processing, visualizing, and integrating different types of experimental data, including supervised and unsupervised machine learning methods, and multi-omics modelling. Students use statistical methods to test hypotheses and assess the validity of conclusions. In problem sets, students read current literature, develop their skills in Python and R, and interpret quantitative results in a biological manner. In the second half of term, students work in groups to complete a project in which they apply the computational approaches covered. </p> <p class="courseblockinstructors seemore"><span><i>B. Bryson, P. Blainey</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.445[J] Methods and Problems in Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.86J" title="1.86[J]" class="bubblelink code" onclick="return showCourse(this, '1.86J');">1.86[J]</a>, <a href="/search/?P=7.492J" title="7.492[J]" class="bubblelink code" onclick="return showCourse(this, '7.492J');">7.492[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=7.492J" title="7.492[J]" class="bubblelink code" onclick="return showCourse(this, '7.492J');">7.492[J]</a>. Preference to first-year Microbiology and Biology students.</p> <p class="courseblockinstructors seemore"><span><i>M. Laub</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.446[J] Microbial Genetics and Evolution</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=1.87J" title="1.87[J]" class="bubblelink code" onclick="return showCourse(this, '1.87J');">1.87[J]</a>, <a href="/search/?P=7.493J" title="7.493[J]" class="bubblelink code" onclick="return showCourse(this, '7.493J');">7.493[J]</a>, <a href="/search/?P=12.493J" title="12.493[J]" class="bubblelink code" onclick="return showCourse(this, '12.493J');">12.493[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.03" title="7.03" class="bubblelink code" onclick="return showCourse(this, '7.03');">7.03</a>, <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>, or permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=7.493J" title="7.493[J]" class="bubblelink code" onclick="return showCourse(this, '7.493J');">7.493[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>A. D. Grossman, O. Cordero</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.450 Applied Microbiology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: (<a href="/search/?P=20.420" title="20.420[J]" class="bubblelink code" onclick="return showCourse(this, '20.420');">20.420[J]</a> and <a href="/search/?P=20.440" title="20.440" class="bubblelink code" onclick="return showCourse(this, '20.440');">20.440</a>) or permission of instructor </span><br/><span class="courseblockterms">G (Fall)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">Compares the complex molecular and cellular interactions in health and disease between commensal microbial communities, pathogens and the human or animal host. Special focus is given to current research on microbe/host interactions, infection of significant importance to public health, and chronic infectious disease. Classwork will include lecture, but emphasize critical evaluation and class discussion of recent scientific papers, and the development of new research agendas in the fields presented. </p> <p class="courseblockinstructors seemore"><span><i>J. C. Niles, K. Ribbeck</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.452[J] Principles of Neuroengineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.422J" title="9.422[J]" class="bubblelink code" onclick="return showCourse(this, '9.422J');">9.422[J]</a>, <a href="/search/?P=MAS.881J" title="MAS.881[J]" class="bubblelink code" onclick="return showCourse(this, 'MAS.881J');">MAS.881[J]</a><br/> Subject meets with <a href="/search/?P=20.352" title="20.352" class="bubblelink code" onclick="return showCourse(this, '20.352');">20.352</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=MAS.881J" title="MAS.881[J]" class="bubblelink code" onclick="return showCourse(this, 'MAS.881J');">MAS.881[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>E. S. Boyden, III</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.454[J] Revolutionary Ventures: How to Invent and Deploy Transformative Technologies</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=9.455J" title="9.455[J]" class="bubblelink code" onclick="return showCourse(this, '9.455J');">9.455[J]</a>, <a href="/search/?P=15.128J" title="15.128[J]" class="bubblelink code" onclick="return showCourse(this, '15.128J');">15.128[J]</a>, <a href="/search/?P=MAS.883J" title="MAS.883[J]" class="bubblelink code" onclick="return showCourse(this, 'MAS.883J');">MAS.883[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">2-0-7 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=MAS.883J" title="MAS.883[J]" class="bubblelink code" onclick="return showCourse(this, 'MAS.883J');">MAS.883[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>E. Boyden, J. Bonsen, J. Jacobson</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.460 Computational Analysis of Biological Data</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.260" title="20.260" class="bubblelink code" onclick="return showCourse(this, '20.260');">20.260</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Presents foundational methods for analysis of complex biological datasets. Covers fundamental concepts in probability, statistics, and linear algebra underlying computational tools that enable generation of biological insights. Assignments focus on practical examples spanning basic science and medical applications. Assumes basic knowledge of calculus and programming (experience with MATLAB, Python, or R is recommended). Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Lauffenburger, F. White</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.463[J] Biomaterials Science and Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=3.963J" title="3.963[J]" class="bubblelink code" onclick="return showCourse(this, '3.963J');">3.963[J]</a><br/> Subject meets with <a href="/search/?P=3.055J" title="3.055[J]" class="bubblelink code" onclick="return showCourse(this, '3.055J');">3.055[J]</a>, <a href="/search/?P=20.363J" title="20.363[J]" class="bubblelink code" onclick="return showCourse(this, '20.363J');">20.363[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a> or permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Covers, at a molecular scale, the analysis and design of materials used in contact with biological systems, and biomimetic strategies aimed at creating new materials based on principles found in biology. Topics include molecular interaction between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Irvine, K. Ribbeck</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.465 Engineering the Immune System in Cancer and Beyond</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.365" title="20.365" class="bubblelink code" onclick="return showCourse(this, '20.365');">20.365</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Examines strategies in clinical and preclinical development for manipulating the immune system to treat and protect against disease. Begins with brief review of immune system. Discusses interaction of tumors with the immune system, followed by approaches by which the immune system can be modulated to attack cancer. Also covers strategies based in biotechnology, chemistry, materials science, and molecular biology to induce immune responses to treat infection, transplantation, and autoimmunity. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. Irvine</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.470[J] Cellular Neurophysiology and Computing</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.794J" title="2.794[J]" class="bubblelink code" onclick="return showCourse(this, '2.794J');">2.794[J]</a>, <a href="/search/?P=6.4812J" title="6.4812[J]" class="bubblelink code" onclick="return showCourse(this, '6.4812J');">6.4812[J]</a>, <a href="/search/?P=9.021J" title="9.021[J]" class="bubblelink code" onclick="return showCourse(this, '9.021J');">9.021[J]</a>, <a href="/search/?P=HST.541J" title="HST.541[J]" class="bubblelink code" onclick="return showCourse(this, 'HST.541J');">HST.541[J]</a><br/> Subject meets with <a href="/search/?P=2.791J" title="2.791[J]" class="bubblelink code" onclick="return showCourse(this, '2.791J');">2.791[J]</a>, <a href="/search/?P=6.4810J" title="6.4810[J]" class="bubblelink code" onclick="return showCourse(this, '6.4810J');">6.4810[J]</a>, <a href="/search/?P=9.21J" title="9.21[J]" class="bubblelink code" onclick="return showCourse(this, '9.21J');">9.21[J]</a>, <a href="/search/?P=20.370J" title="20.370[J]" class="bubblelink code" onclick="return showCourse(this, '20.370J');">20.370[J]</a></span><br/><span class="courseblockprereq">Prereq: (<a href="/search/?P=8.02|8.021|8.022" onclick="return showCourse(this, '8.02|8.021|8.022');">Physics II (GIR)</a>, <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a>, and (<a href="/search/?P=2.005" title="2.005" class="bubblelink code" onclick="return showCourse(this, '2.005');">2.005</a>, <a href="/search/?P=6.2000" title="6.2000" class="bubblelink code" onclick="return showCourse(this, '6.2000');">6.2000</a>, <a href="/search/?P=6.3000" title="6.3000" class="bubblelink code" onclick="return showCourse(this, '6.3000');">6.3000</a>, <a href="/search/?P=10.301" title="10.301" class="bubblelink code" onclick="return showCourse(this, '10.301');">10.301</a>, or <a href="/search/?P=20.110" title="20.110[J]" class="bubblelink code" onclick="return showCourse(this, '20.110');">20.110[J]</a>)) or permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">5-2-5 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=6.4812J" title="6.4812[J]" class="bubblelink code" onclick="return showCourse(this, '6.4812J');">6.4812[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>J. Han, T. Heldt</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.473 Foundations of Cell Therapy Manufacturing</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.373" title="20.373" class="bubblelink code" onclick="return showCourse(this, '20.373');">20.373</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Seminar examines cell therapy manufacturing, the ex vivo production of human cells to be delivered to humans as a product for medical benefit. Includes a review of cell biology and immunology. Addresses topics such as governmental regulations applying to cell therapy production; the manufacture of cell-based therapeutics, including cell culture unit operations, genetic engineering or editing of cells; process engineering of cell therapy products; and the analytics of cell therapy manufacturing processes. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>K. Van Vliet</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.475 Applied Developmental Biology and Tissue Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=20.375" title="20.375" class="bubblelink code" onclick="return showCourse(this, '20.375');">20.375</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">This subject addresses the integration of engineering and biology design principles to create human tissues and organs for regenerative medicine to drug development. Overview of embryogenesis; how morphogenic phenomena are governed by biochemical and biophysical cues. Analysis of in vitro generation of human brain, gut, and other organoids from stem cells. Roles of biomaterials and microreactors in improving organoid formation and function. Organoid use in modeling disease and physiology in vitro. Engineering and biological principles of reconstructing tissues and organs from postnatal donor cells using biomaterials scaffolds and bioreactors. Select applications such as liver disease, brain disorders, and others. Graduate students will have additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>L. Griffith</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.486[J] Case Studies and Strategies in Drug Discovery and Development</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.549J" title="7.549[J]" class="bubblelink code" onclick="return showCourse(this, '7.549J');">7.549[J]</a>, <a href="/search/?P=15.137J" title="15.137[J]" class="bubblelink code" onclick="return showCourse(this, '15.137J');">15.137[J]</a>, <a href="/search/?P=HST.916J" title="HST.916[J]" class="bubblelink code" onclick="return showCourse(this, 'HST.916J');">HST.916[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">Aims to develop appreciation for the stages of drug discovery and development, from target identification, to the submission of preclinical and clinical data to regulatory authorities for marketing approval. Following introductory lectures on the process of drug development, students working in small teams analyze how one of four new drugs or drug candidates traversed the discovery/development landscape. For each case, an outside expert from the sponsoring drug company or pivotal clinical trial principal investigator provides guidance and critiques the teams' presentations to the class. </p> <p class="courseblockinstructors seemore"><span><i>A. W. Wood</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.487[J] Optical Microscopy and Spectroscopy for Biology and Medicine</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=2.715J" title="2.715[J]" class="bubblelink code" onclick="return showCourse(this, '2.715J');">2.715[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=2.715J" title="2.715[J]" class="bubblelink code" onclick="return showCourse(this, '2.715J');">2.715[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>P. T. So, C. Sheppard</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.490 Computational Systems Biology: Deep Learning in the Life Sciences</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Subject meets with <a href="/search/?P=6.8710J" title="6.8710[J]" class="bubblelink code" onclick="return showCourse(this, '6.8710J');">6.8710[J]</a>, <a href="/search/?P=6.8711J" title="6.8711[J]" class="bubblelink code" onclick="return showCourse(this, '6.8711J');">6.8711[J]</a>, <a href="/search/?P=20.390J" title="20.390[J]" class="bubblelink code" onclick="return showCourse(this, '20.390J');">20.390[J]</a>, <a href="/search/?P=HST.506J" title="HST.506[J]" class="bubblelink code" onclick="return showCourse(this, 'HST.506J');">HST.506[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.012|7.013|7.014|7.015|7.016" onclick="return showCourse(this, '7.012|7.013|7.014|7.015|7.016');">Biology (GIR)</a> and (6.041 or <a href="/search/?P=18.600" title="18.600" class="bubblelink code" onclick="return showCourse(this, '18.600');">18.600</a>) </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">Presents innovative approaches to computational problems in the life sciences, focusing on deep learning-based approaches with comparisons to conventional methods. Topics include protein-DNA interaction, chromatin accessibility, regulatory variant interpretation, medical image understanding, medical record understanding, therapeutic design, and experiment design (the choice and interpretation of interventions). Focuses on machine learning model selection, robustness, and interpretation. Teams complete a multidisciplinary final research project using TensorFlow or other framework. Provides a comprehensive introduction to each life sciences problem, but relies upon students understanding probabilistic problem formulations. Students taking graduate version complete additional assignments. </p> <p class="courseblockinstructors seemore"><span><i>D. K. Gifford</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.507[J] Introduction to Biological Chemistry</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=5.07J" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07J');">5.07[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=5.12" title="5.12" class="bubblelink code" onclick="return showCourse(this, '5.12');">5.12</a> </span><br/><span class="courseblockterms">U (Fall)</span><br/><span class="courseblockhours">5-0-7 units. REST</span><br/><span class="courseblockoptional">Credit cannot also be received for <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a></span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=5.07J" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07J');">5.07[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>B. Pentelute, E. Nolan</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.535[J] Protein Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=10.535J" title="10.535[J]" class="bubblelink code" onclick="return showCourse(this, '10.535J');">10.535[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=18.03" title="18.03" class="bubblelink code" onclick="return showCourse(this, '18.03');">18.03</a> and (<a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a> or <a href="/search/?P=7.05" title="7.05" class="bubblelink code" onclick="return showCourse(this, '7.05');">7.05</a>) </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=10.535J" title="10.535[J]" class="bubblelink code" onclick="return showCourse(this, '10.535J');">10.535[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>K. D. Wittrup</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.554[J] Advances in Chemical Biology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=5.54J" title="5.54[J]" class="bubblelink code" onclick="return showCourse(this, '5.54J');">5.54[J]</a>, <a href="/search/?P=7.540J" title="7.540[J]" class="bubblelink code" onclick="return showCourse(this, '7.540J');">7.540[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=5.07" title="5.07[J]" class="bubblelink code" onclick="return showCourse(this, '5.07');">5.07[J]</a>, <a href="/search/?P=5.13" title="5.13" class="bubblelink code" onclick="return showCourse(this, '5.13');">5.13</a>, <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a>, and permission of instructor </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">3-0-9 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=5.54J" title="5.54[J]" class="bubblelink code" onclick="return showCourse(this, '5.54J');">5.54[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>L. Kiessling, M. Shoulders</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.560 Statistics for Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Spring; second half of term)<br/> Not offered regularly; consult department</span><br/><span class="courseblockhours">2-0-2 units</span> </p> <p class="courseblockdesc">Provides basic tools for analyzing experimental data, interpreting statistical reports in the literature, and reasoning under uncertain situations. Topics include probability theory, statistical tests, data exploration, Bayesian statistics, and machine learning. Emphasizes discussion and hands-on learning. Experience with MATLAB, Python, or R recommended. </p> <p class="courseblockinstructors seemore"><span><i>S. Olesen</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.561[J] Eukaryotic Cell Biology: Principles and Practice</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.61J" title="7.61[J]" class="bubblelink code" onclick="return showCourse(this, '7.61J');">7.61[J]</a></span><br/><span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">Acad Year 2024-2025: Not offered<br/> Acad Year 2025-2026: G (Fall)</span><br/><span class="courseblockhours">4-0-8 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=7.61J" title="7.61[J]" class="bubblelink code" onclick="return showCourse(this, '7.61J');">7.61[J]</a>. Enrollment limited.</p> <p class="courseblockinstructors seemore"><span><i>M. Krieger, M. Yaffe</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.586[J] Science and Business of Biotechnology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.546J" title="7.546[J]" class="bubblelink code" onclick="return showCourse(this, '7.546J');">7.546[J]</a>, <a href="/search/?P=15.480J" title="15.480[J]" class="bubblelink code" onclick="return showCourse(this, '15.480J');">15.480[J]</a></span><br/><span class="courseblockprereq">Prereq: None. <i>Coreq: <a href="/search/?P=15.401" title="15.401" class="bubblelink code" onclick="return showCourse(this, '15.401');">15.401</a></i>; permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">3-0-6 units</span> </p> <p class="courseblockdesc">Covers the new types of drugs and other therapeutics in current practice and under development, the financing and business structures of early-stage biotechnology companies, and the evaluation of their risk/reward profiles. Includes a series of live case studies with industry leaders of both established and emerging biotechnology companies as guest speakers, focusing on the underlying science and engineering as well as core financing and business issues. Students must possess a basic background in cellular and molecular biology. </p> <p class="courseblockinstructors seemore"><span><i>J. Chen, A. Koehler, A. Lo, H. Lodish</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.630[J] Immunology</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.63J" title="7.63[J]" class="bubblelink code" onclick="return showCourse(this, '7.63J');">7.63[J]</a><br/> Subject meets with <a href="/search/?P=7.23J" title="7.23[J]" class="bubblelink code" onclick="return showCourse(this, '7.23J');">7.23[J]</a>, <a href="/search/?P=20.230J" title="20.230[J]" class="bubblelink code" onclick="return showCourse(this, '20.230J');">20.230[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=7.06" title="7.06" class="bubblelink code" onclick="return showCourse(this, '7.06');">7.06</a> and permission of instructor </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">5-0-7 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=7.63J" title="7.63[J]" class="bubblelink code" onclick="return showCourse(this, '7.63J');">7.63[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>S. Spranger, M. Birnbaum</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.902 Independent Study in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Opportunity for independent study under regular supervision by a faculty member. Projects require prior approval, as well as a substantive paper. Minimum 12 units required. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.903 Independent Study in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Opportunity for independent study under regular supervision by a faculty member. Projects require prior approval, as well as a substantive paper. Minimum 6-12 units required. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.920 Practical Work Experience</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">0-1-0 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">For Course 20 students participating in off-campus professional experiences in biological engineering. Before registering for this subject, students must have an offer from a company or organization and must identify a BE advisor. Upon completion, student must submit a letter from the company or organization describing the experience, along with a substantive final report from the student approved by the MIT advisor. Subject to departmental approval. Consult departmental undergraduate office. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.930[J] Research Experience in Biopharma</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=7.930J" title="7.930[J]" class="bubblelink code" onclick="return showCourse(this, '7.930J');">7.930[J]</a>, <a href="/search/?P=CSB.930J" title="CSB.930[J]" class="bubblelink code" onclick="return showCourse(this, 'CSB.930J');">CSB.930[J]</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall)</span><br/><span class="courseblockhours">2-10-0 units</span> </p> <p class="courseblockdesc">Provides exposure to industrial science and develops skills necessary for success in such an environment. Under the guidance of an industrial mentor, students participate in on-site research at a local biopharmaceutical company where they observe and participate in industrial science. Serves as a real-time case study to internalize the factors that shape R&D in industry, including the purpose and scope of a project, key decision points in the past and future, and strategies for execution. Students utilize company resources and work with a scientific team to contribute to the goals of their assigned project; they then present project results to the company and class, emphasizing the logic that dictated their work and their ideas for future directions. Lecture component focuses on professional development. </p> <p class="courseblockinstructors seemore"><span><i>C. Burge</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.945 Practical Experience in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">0-1-0 units</span> </p> <p class="courseblockdesc">For Course 20 doctoral students participating in off-campus research, academic experiences, or internships in biological engineering. For internship experiences, an offer of employment from a company or organization is required prior to enrollment; employers must document work accomplished. A written report is required upon completion of a minimum of four weeks of off-campus experience. Proposals must be approved by department. </p> <p class="courseblockinstructors seemore"><span><i>K. Ribbeck, P. Blainey聽</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.950 Research Problems in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Directed research in the fields of bioengineering and environmental health. Limited to BE students.</p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.951 Thesis Proposal</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring, Summer)</span><br/><span class="courseblockhours">0-24-0 units</span> </p> <p class="courseblockdesc">Thesis proposal research and presentation to the thesis committee. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.960 Teaching Experience in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">For qualified graduate students interested in teaching. Tutorial, laboratory, or classroom teaching under the supervision of a faculty member. Enrollment limited by availability of suitable teaching assignments.</p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.BME Undergraduate Research in Biomedical Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Individual research project with biomedical or clinical focus, arranged with appropriate faculty member or approved advisor. Forms and instructions for the proposal and final report are available in the BE Undergraduate Office. </p> <p class="courseblockinstructors seemore"><span><i>Consult Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.C01[J] Machine Learning for Molecular Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=3.C01J" title="3.C01[J]" class="bubblelink code" onclick="return showCourse(this, '3.C01J');">3.C01[J]</a>, <a href="/search/?P=10.C01J" title="10.C01[J]" class="bubblelink code" onclick="return showCourse(this, '10.C01J');">10.C01[J]</a><br/> Subject meets with <a href="/search/?P=3.C51J" title="3.C51[J]" class="bubblelink code" onclick="return showCourse(this, '3.C51J');">3.C51[J]</a>, <a href="/search/?P=7.C01" title="7.C01" class="bubblelink code" onclick="return showCourse(this, '7.C01');">7.C01</a>, <a href="/search/?P=7.C51" title="7.C51" class="bubblelink code" onclick="return showCourse(this, '7.C51');">7.C51</a>, <a href="/search/?P=10.C51J" title="10.C51[J]" class="bubblelink code" onclick="return showCourse(this, '10.C51J');">10.C51[J]</a>, <a href="/search/?P=20.C51J" title="20.C51[J]" class="bubblelink code" onclick="return showCourse(this, '20.C51J');">20.C51[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a>, <a href="/search/?P=6.100A" title="6.100A" class="bubblelink code" onclick="return showCourse(this, '6.100A');">6.100A</a>, and <a href="/search/?P=6.C01" title="6.C01" class="bubblelink code" onclick="return showCourse(this, '6.C01');">6.C01</a> </span><br/><span class="courseblockterms">U (Spring)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=3.C01J" title="3.C01[J]" class="bubblelink code" onclick="return showCourse(this, '3.C01J');">3.C01[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>R. Gomez-Bombarelli, C. Coley, E. Fraenkel</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.C51[J] Machine Learning for Molecular Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Same subject as <a href="/search/?P=3.C51J" title="3.C51[J]" class="bubblelink code" onclick="return showCourse(this, '3.C51J');">3.C51[J]</a>, <a href="/search/?P=10.C51J" title="10.C51[J]" class="bubblelink code" onclick="return showCourse(this, '10.C51J');">10.C51[J]</a><br/> Subject meets with <a href="/search/?P=3.C01J" title="3.C01[J]" class="bubblelink code" onclick="return showCourse(this, '3.C01J');">3.C01[J]</a>, <a href="/search/?P=7.C01" title="7.C01" class="bubblelink code" onclick="return showCourse(this, '7.C01');">7.C01</a>, <a href="/search/?P=7.C51" title="7.C51" class="bubblelink code" onclick="return showCourse(this, '7.C51');">7.C51</a>, <a href="/search/?P=10.C01J" title="10.C01[J]" class="bubblelink code" onclick="return showCourse(this, '10.C01J');">10.C01[J]</a>, <a href="/search/?P=20.C01J" title="20.C01[J]" class="bubblelink code" onclick="return showCourse(this, '20.C01J');">20.C01[J]</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=18.02|18.02A|18.022|18.024" onclick="return showCourse(this, '18.02|18.02A|18.022|18.024');">Calculus II (GIR)</a>, <a href="/search/?P=6.100A" title="6.100A" class="bubblelink code" onclick="return showCourse(this, '6.100A');">6.100A</a>, and <a href="/search/?P=6.C51" title="6.C51" class="bubblelink code" onclick="return showCourse(this, '6.C51');">6.C51</a> </span><br/><span class="courseblockterms">G (Spring)</span><br/><span class="courseblockhours">2-0-4 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=3.C51J" title="3.C51[J]" class="bubblelink code" onclick="return showCourse(this, '3.C51J');">3.C51[J]</a>. </p> <p class="courseblockinstructors seemore"><span><i>R. Gomez-Bombarelli, C. Coley, E. Fraenkel</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.EPE UPOP Engineering Practice Experience</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Engineering School-Wide Elective Subject.<br/> Offered under: <a href="/search/?P=1.EPE" title="1.EPE" class="bubblelink code" onclick="return showCourse(this, '1.EPE');">1.EPE</a>, <a href="/search/?P=2.EPE" title="2.EPE" class="bubblelink code" onclick="return showCourse(this, '2.EPE');">2.EPE</a>, <a href="/search/?P=3.EPE" title="3.EPE" class="bubblelink code" onclick="return showCourse(this, '3.EPE');">3.EPE</a>, <a href="/search/?P=6.EPE" title="6.EPE" class="bubblelink code" onclick="return showCourse(this, '6.EPE');">6.EPE</a>, <a href="/search/?P=8.EPE" title="8.EPE" class="bubblelink code" onclick="return showCourse(this, '8.EPE');">8.EPE</a>, <a href="/search/?P=10.EPE" title="10.EPE" class="bubblelink code" onclick="return showCourse(this, '10.EPE');">10.EPE</a>, <a href="/search/?P=15.EPE" title="15.EPE" class="bubblelink code" onclick="return showCourse(this, '15.EPE');">15.EPE</a>, <a href="/search/?P=16.EPE" title="16.EPE" class="bubblelink code" onclick="return showCourse(this, '16.EPE');">16.EPE</a>, <a href="/search/?P=20.EPE" title="20.EPE" class="bubblelink code" onclick="return showCourse(this, '20.EPE');">20.EPE</a>, <a href="/search/?P=22.EPE" title="22.EPE" class="bubblelink code" onclick="return showCourse(this, '22.EPE');">22.EPE</a></span><br/><span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">0-0-1 units</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=2.EPE" title="2.EPE" class="bubblelink code" onclick="return showCourse(this, '2.EPE');">2.EPE</a>. Application required; consult UPOP website for more information.</p> <p class="courseblockinstructors seemore"><span><i>K. Tan-Tiongco, D. Fordell</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.EPW UPOP Engineering Practice Workshop</strong></span></h4> <p class="courseblockextra"> <span class="courseblockcluster">Engineering School-Wide Elective Subject.<br/> Offered under: <a href="/search/?P=1.EPW" title="1.EPW" class="bubblelink code" onclick="return showCourse(this, '1.EPW');">1.EPW</a>, <a href="/search/?P=2.EPW" title="2.EPW" class="bubblelink code" onclick="return showCourse(this, '2.EPW');">2.EPW</a>, <a href="/search/?P=3.EPW" title="3.EPW" class="bubblelink code" onclick="return showCourse(this, '3.EPW');">3.EPW</a>, <a href="/search/?P=6.EPW" title="6.EPW" class="bubblelink code" onclick="return showCourse(this, '6.EPW');">6.EPW</a>, <a href="/search/?P=10.EPW" title="10.EPW" class="bubblelink code" onclick="return showCourse(this, '10.EPW');">10.EPW</a>, <a href="/search/?P=16.EPW" title="16.EPW" class="bubblelink code" onclick="return showCourse(this, '16.EPW');">16.EPW</a>, <a href="/search/?P=20.EPW" title="20.EPW" class="bubblelink code" onclick="return showCourse(this, '20.EPW');">20.EPW</a>, <a href="/search/?P=22.EPW" title="22.EPW" class="bubblelink code" onclick="return showCourse(this, '22.EPW');">22.EPW</a></span><br/><span class="courseblockprereq">Prereq: <a href="/search/?P=2.EPE" title="2.EPE" class="bubblelink code" onclick="return showCourse(this, '2.EPE');">2.EPE</a> </span><br/><span class="courseblockterms">U (Fall, IAP, Spring)</span><br/><span class="courseblockhours">1-0-0 units</span> </p> <p class="courseblockdesc">See description under subject <a href="/search/?P=2.EPW" title="2.EPW" class="bubblelink code" onclick="return showCourse(this, '2.EPW');">2.EPW</a>. Enrollment limited to those in the UPOP program.</p> <p class="courseblockinstructors seemore"><span><i>K. Tan-Tiongco, D. Fordell</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.S900 Special Subject in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.S901 Special Subject in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.S940 Special Subject in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">U (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.S947 Special Subject in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.S948 Special Subject in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.S949 Special Subject in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.S952 Special Subject in Biological Engineering</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, Spring)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Detailed discussion of selected topics of current interest. Classwork in various areas not covered by regular subjects. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.THG Graduate Thesis</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: Permission of instructor </span><br/><span class="courseblockterms">G (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of research leading to the writing of an SM or PhD thesis; to be arranged by the student and the MIT faculty advisor. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.THU Undergraduate BE Thesis</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, IAP, Spring)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Program of research leading to the writing of an SB thesis; to be arranged by the student under approved supervision. </p> <p class="courseblockinstructors seemore"><span><i>Staff</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.UR Undergraduate Research Opportunities</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged [P/D/F]</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Laboratory research in the fields of bioengineering or environmental health. May be extended over multiple terms. </p> <p class="courseblockinstructors seemore"><span><i>S. Manalis</i></span></p> </div><div class="courseblock"> <h4 class="courseblocktitle"><span font="Meta Pro"><strong>20.URG Undergraduate Research Opportunities</strong></span></h4> <p class="courseblockextra"> <span class="courseblockprereq">Prereq: None </span><br/><span class="courseblockterms">U (Fall, IAP, Spring, Summer)</span><br/><span class="courseblockhours">Units arranged</span><br/><span class="courseblockoptional">Can be repeated for credit.</span> </p> <p class="courseblockdesc">Emphasizes direct and active involvement in laboratory research in bioengineering or environmental health. May be extended over multiple terms. </p> <p class="courseblockinstructors seemore"><span><i>Consult S. Manalis</i></span></p> </div></div> </div> </div>  </div> </div>  <div id="footer" role="contentinfo"> <div class="wrap"> <div id="footer-links"> <a href="http://mitadmissions.org/apply" target="_blank">Admissions</a><a href="http://sfs.mit.edu/" target="_blank">Financial Aid</a><a href="http://web.mit.edu/registrar/" target="_blank">Registrar</a><a href="http://web.mit.edu/iap/" target="_blank">IAP</a><a href="/summer/">Summer</a><a href="http://professional.mit.edu" target="_blank">Professional Education</a><a href="https://www.edx.org/school/mitx" class="mitx" target="_blank">MITx</a><a href="https://outreach.mit.edu/" target="_blank">K-12</a><a href="http://whereis.mit.edu/" target="_blank">Campus Map</a><br/><a href="https://officesdirectory.mit.edu/" target="_blank">Directories</a><a href="/about-bulletin/">About the Bulletin</a><a href="/nondiscrimination-policy/">Nondiscrimination Policy</a><a href="/changelog/">Changes</a><a href="/help/">Help</a><a href="https://accessibility.mit.edu/" target="_blank">Accessibility</a> </div> <div id="footer-branding" class="clearfix"> <div class="foot-col" id="right"> <div id="footer-mit-logo"><img src="/images/mit-logo-footer.svg" alt="MIT" width="185px" /></div> </div> <div class="foot-col" id="left"> <div id="footer-bulletin"><img src="/images/mit-bulletin-logo-footer-24-25.png" alt="MIT Academic Bulletin" /></div> <div id="footer-contact">77 Massachusetts Avenue<br/>Cambridge, MA 02139-4307</div> </div> </div> </div> <a href="#header" id="totop"><span class="sr-only">Back to top</span></a> </div>  <div id="print-dialog" class="screen noscript" role="dialog"> <div class="print-header"> Print Options </div> <div class="print-body"> <div class="print-option"> <div class="option-head"> <a href="#" onclick="hidePrintDialog();window.print();return false">Send Page to Printer</a> </div> <p> <em>Print this page.</em> </p> </div> <div class="print-option"><div class="option-head"><a href="20.pdf" target="_blank">Download PDF of this Page</a></div><p><em>The PDF includes all information on this page and its related tabs. 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