Search results for: immunotolerance

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immunotolerance</title> <meta name="description" content="Search results for: immunotolerance"> <meta name="keywords" content="immunotolerance"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="immunotolerance"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: immunotolerance</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Immunomodulation by Interleukin-10 Therapy in Mouse Airway Transplantation </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammaad%20Afzal%20Khan">Mohammaad Afzal Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghazi%20Abdulmalik%20Ashoor"> Ghazi Abdulmalik Ashoor </a>, <a href="https://publications.waset.org/abstracts/search?q=Fatimah%20Alanazi"> Fatimah Alanazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Talal%20Shamma"> Talal Shamma</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20Altuhami"> Abdullah Altuhami</a>, <a href="https://publications.waset.org/abstracts/search?q=Hala%20Abdalrahman%20Ahmed"> Hala Abdalrahman Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20Mohammed%20Assiri"> Abdullah Mohammed Assiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Dieter%20Clemens%20Broering"> Dieter Clemens Broering</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microvascular injuries during inflammation are key causes of transplant malfunctioning and permanent failure, which play a major role in the development of chronic rejection of the transplanted organ. Inflammation-induced microvascular loss is a promising area to investigate the decisive roles of regulatory and effector responses. The present study was designed to investigate the impact of IL-10 on immunotolerance, in particular, the microenvironment of the allograft during rejection. Here, we investigated the effects of IL-10 blockade/ reconstitution and serially monitored regulatory T cells (Tregs), graft microvasculature, and airway epithelium in rejecting airway transplants. We demonstrated that the blocking/reconstitution of IL-10 significantly modulates CD4+FOXP3+ Tregs, microvasculature, and airway epithelium during rejection. Our findings further highlighted that blockade of IL-10 upregulated proinflammatory cytokines, IL-2, IL-1β, IFN-γ, IL-15, and IL-23, but suppressed IL-5 secretion during rejection; however, reconstitution of IL-10 significantly upregulated CD4+FOXP3+ Tregs, tissue oxygenation/blood flow and airway repair. Collectively, these findings demonstrate a potential reparative modulation of IL-10 during microvascular and epithelial repair, which could provide a vital therapeutic window to rejecting transplants in clinical practice. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=interleukin%20-10" title="interleukin -10">interleukin -10</a>, <a href="https://publications.waset.org/abstracts/search?q=regulatory%20T%20cells" title=" regulatory T cells"> regulatory T cells</a>, <a href="https://publications.waset.org/abstracts/search?q=allograft%20rejection" title=" allograft rejection"> allograft rejection</a>, <a href="https://publications.waset.org/abstracts/search?q=immunotolerance" title=" immunotolerance"> immunotolerance</a> </p> <a href="https://publications.waset.org/abstracts/114156/immunomodulation-by-interleukin-10-therapy-in-mouse-airway-transplantation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/114156.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">174</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> iPSC-derived MSC Mediated Immunosuppression during Mouse Airway Transplantation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Afzal%20Khan">Mohammad Afzal Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatimah%20Alanazi"> Fatimah Alanazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hala%20Abdalrahman%20Ahmed"> Hala Abdalrahman Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Talal%20Shamma"> Talal Shamma</a>, <a href="https://publications.waset.org/abstracts/search?q=Kilian%20Kelly"> Kilian Kelly</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20A.%20Hammad"> Mohammed A. Hammad</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20O.%20Alawad"> Abdullah O. Alawad</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20Mohammed%20Assiri"> Abdullah Mohammed Assiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Dieter%20Clemens%20Broering"> Dieter Clemens Broering</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. Despite the remarkable short-term recovery, long-term lung survival continues to face several significant challenges, including chronic rejection and severe toxic side-effects due to global immunosuppression. Stem cell-based immunotherapy has been recognized as a crucial immunoregulatory regimen in various preclinical and clinical studies. Despite initial therapeutic outcomes, conventional stem cells face key limitations. The Cymerus™ manufacturing facilitates the production of a virtually limitless supply of consistent human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells, which could play a key role in selective immunosuppression and graft repair during rejection. Here, we demonstrated the impact of iPSC-derived human MSCs on the development of immune-tolerance and long-term graft survival in mouse orthotopic airway allografts. BALB/c→C57BL/6 allografts were reconstituted with iPSC-derived MSCs (2 million/transplant/ at d0), and allografts were examined for regulatory T cells (Tregs), oxygenation, microvascular blood flow, airway epithelium and collagen deposition during rejection. We demonstrated that iPSC-derived MSC treatment leads to significant increase in tissue expression of hTSG-6 protein, followed by an upregulation of mouse Tregs and IL-5, IL-10, IL-15 cytokines, which augments graft microvascular blood flow and oxygenation, and thereby maintained a healthy airway epithelium and prevented the subepithelial deposition of collagen at d90 post-transplantation. Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune-tolerance and rescue allograft from sustained hypoxic/ischemic phase and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=stem%20cell%20therapy" title="stem cell therapy">stem cell therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=immunotolerance" title=" immunotolerance"> immunotolerance</a>, <a href="https://publications.waset.org/abstracts/search?q=regulatory%20T%20cells" title=" regulatory T cells"> regulatory T cells</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoxia%20and%20ischemia" title=" hypoxia and ischemia"> hypoxia and ischemia</a>, <a href="https://publications.waset.org/abstracts/search?q=microvasculature" title=" microvasculature"> microvasculature</a> </p> <a href="https://publications.waset.org/abstracts/114237/ipsc-derived-msc-mediated-immunosuppression-during-mouse-airway-transplantation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/114237.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">158</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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Search results for: immunotolerance