Cancer blood test ‘enormously exciting’

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Scientist working with blood samples in a lab"/> <meta property="fb:pages" content="1143803202301544,317278538359186,1392506827668140,742734325867560,185246968166196,156060587793370,137920769558355,193435954068976,21263239760,156400551056385,929399697073756,154344434967,228735667216,80758950658,260212261199,294662213128,1086451581439054,283348121682053,295830058648,239931389545417,304314573046,310719525611571,647687225371774,1159932557403143,286567251709437,1731770190373618,125309456546,163571453661989,285361880228,512423982152360,238003846549831,176663550714,260967092113,118450564909230,100978706649892,15286229625,122103087870579,120655094632228,102814153147070,124715648647,153132638110668,150467675018739"/> <meta name="twitter:card" content="summary_large_image"> <meta name="twitter:site" content="@BBCWorld"> <meta name="twitter:title" content="Cancer blood test ‘enormously exciting’"> <meta name="twitter:description" content="Scientists move nearer to one of the biggest goals in medicine - a universal blood test for cancer."> <meta name="twitter:creator" content="@BBCWorld"> <meta name="twitter:image:src" content="https://ichef.bbci.co.uk/images/ic/1024x576/p05vfxk7.jpg"> <meta name="twitter:image:alt" content="Scientist working with blood samples in a lab"/> <meta name="twitter:domain" content="www.bbc.com"> <script type="application/ld+json"> {"@context":"https:\/\/web.archive.org\/web\/20180130002512\/http:\/\/schema.org","@type":"ReportageNewsArticle","url":"https:\/\/web.archive.org\/web\/20180130002512\/http:\/\/www.bbc.com\/news\/health-42736764","publisher":{"@type":"NewsMediaOrganization","name":"BBC News","publishingPrinciples":"https:\/\/web.archive.org\/web\/20180130002512\/http:\/\/www.bbc.co.uk\/news\/help-41670342","logo":{"@type":"ImageObject","url":"https:\/\/web.archive.org\/web\/20180130002512\/http:\/\/www.bbc.co.uk\/news\/special\/2015\/newsspec_10857\/bbc_news_logo.png?cb=1"}},"datePublished":"2018-01-19T00:25:31+00:00","dateModified":"2018-01-19T00:25:31+00:00","headline":"Cancer blood test \u2018enormously exciting\u2019","image":{"@type":"ImageObject","width":720,"height":405,"url":"https:\/\/web.archive.org\/web\/20180130002512\/https:\/\/ichef.bbci.co.uk\/images\/ic\/720x405\/p05vfxk7.jpg"},"thumbnailUrl":"https:\/\/web.archive.org\/web\/20180130002512\/https:\/\/ichef.bbci.co.uk\/images\/ic\/208x117\/p05vfxk7.jpg","author":{"@type":"Person","name":"James Gallagher","sameAs":["https:\/\/web.archive.org\/web\/20180130002512\/https:\/\/twitter.com\/JamesTGallagher"]},"mainEntityOfPage":"https:\/\/web.archive.org\/web\/20180130002512\/http:\/\/www.bbc.com\/news\/health-42736764","video":{"@type":"VideoObject","name":"Cancer blood test shows promise","description":"Scientists in the US have trialled a blood test that detects eight common forms of cancer in 1,000 patients, and found that they could pick up 70% of their cancers. \n\nThe CancerSEEK test is now being tested in people who have not yet been diagnosed with cancer, which will be the real test of its usefulness. At present, the test can only detect 40% of stage 1 cancers.\n\nIf successful, experts say in the future it could be used alongside other screening tools to catch cancer early and save lives.","duration":"PT45S","thumbnailUrl":"https:\/\/web.archive.org\/web\/20180130002512\/https:\/\/ichef.bbci.co.uk\/images\/ic\/208x117\/p05vfxk7.jpg","uploadDate":"2018-01-19T14:06:07+00:00"}} </script> <meta name="apple-mobile-web-app-title" content="BBC News"> <link rel="apple-touch-icon-precomposed" sizes="57x57" href="https://web.archive.org/web/20180130002512im_/http://static.bbci.co.uk/news/1.226.02302/apple-touch-icon-57x57-precomposed.png"> <link rel="apple-touch-icon-precomposed" sizes="72x72" href="https://web.archive.org/web/20180130002512im_/http://static.bbci.co.uk/news/1.226.02302/apple-touch-icon-72x72-precomposed.png"> <link rel="apple-touch-icon-precomposed" sizes="114x114" href="https://web.archive.org/web/20180130002512im_/http://static.bbci.co.uk/news/1.226.02302/apple-touch-icon-114x114-precomposed.png"> <link rel="apple-touch-icon-precomposed" sizes="144x144" href="https://web.archive.org/web/20180130002512im_/http://static.bbci.co.uk/news/1.226.02302/apple-touch-icon.png"> <link rel="apple-touch-icon" href="https://web.archive.org/web/20180130002512im_/http://static.bbci.co.uk/news/1.226.02302/apple-touch-icon.png"> <link rel="apple-touch-startup-image" href="http://static.bbci.co.uk/news/1.226.02302/web-app-launch-icon.png"> <meta name="application-name" content="BBC News"> <meta name="msapplication-TileImage" content="BBC News"> <meta name="msapplication-TileColor" content="#bb1919"> <meta name="mobile-web-app-capable" content="yes"> <meta http-equiv="cleartype" content="on"> <meta name="robots" content="NOODP,NOYDIR"/> <meta name="theme-color" content="#bb1919"> <script type="text/javascript">var _sf_startpt=(new Date()).getTime()</script> <script> (function() { if (navigator.userAgent.match(/IEMobile\/10\.0/)) { var msViewportStyle = document.createElement("style"); 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class="story-body"> <h1 class="story-body__h1">Cancer blood test ‘enormously exciting’</h1> <div class="byline"> <span class="byline__name">By James Gallagher</span> <span class="byline__title">Health and science correspondent, BBC News</span> </div> <div class="with-extracted-share-icons"> <div class="story-body__mini-info-list-and-share"> <div class="story-body__mini-info-list-and-share-row"> <div class="mini-info-list-wrap"> <ul class="mini-info-list"> <li class="mini-info-list__item"><div class="date date--v2" data-seconds="1516321531" data-datetime="19 January 2018">19 January 2018</div></li> <li class="mini-info-list__item"><span id="dna-comment-count___CPS__42736764" class="js-comment-count comment-count" data-comments-id="__CPS__42736764"></span><span class="off-screen"> comments</span></li> </ul> </div> <div class="share-tools--event-tag"> <div id="comp-pattern-library-5" class="distinct-component-group container-twite"> <ul class="sharetools"> <li class="twite__channel-out 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href="https://web.archive.org/web/20180130002512/http://www.bbc.com/news/health-42736764" tabindex="-1" contenteditable="true">http://www.bbc.com/news/health-42736764</a> </div> <a class="twite__read-more" href="https://web.archive.org/web/20180130002512/http://www.bbc.co.uk/faqs/questions/bbc_online/sharing">Read more about sharing.</a> <p class="twite__new-window" aria-hidden="true">These are external links and will open in a new window</p> <button class="twite__close-button"> <span class="off-screen">Close share panel</span> <div class="twite__close-button-graphic" aria-hidden="true"></div> </button> </div> </li> </ul> </div> </div> </div> <div id="topic-tags"><div id="u7428749785758555"><noscript></noscript></div></div> </div> </div> <div class="story-body__inner" property="articleBody"> <figure class="media-with-caption"> <div class="player-with-placeholder"> <img class="media-placeholder player-with-placeholder__image lead-video-placeholder" src="https://web.archive.org/web/20180130002512im_/https://ichef.bbci.co.uk/images/ic/720x405/p05vfxk7.jpg"> <div class="player-with-placeholder__caption">Media playback is unsupported on your device</div> <div class="player-with-placeholder"> <div class="media-player-wrapper"> <figure class="js-media-player-unprocessed media-player" data-playable="{"settings":{"counterName":"news.health.story.42736764.page","edition":"US","pageType":"eav2","uniqueID":"42736764","ui":{"locale":{"lang":"en-gb"}},"externalEmbedUrl":"http:\/\/www.bbc.com\/news\/av\/embed\/p05vf6th\/42736764","insideIframe":false,"statsObject":{"clipPID":"p05vf6td"},"playlistObject":{"title":"Cancer blood test shows promise but more research is needed, says Prof Richard Marais","holdingImageURL":"https:\/\/ichef.bbci.co.uk\/images\/ic\/$recipe\/p05vfxk7.jpg","guidance":"","embedRights":"allowed","summary":"Cancer blood test shows promise but more research is needed, says Prof Richard Marais","liveRewind":false,"simulcast":false,"items":[{"vpid":"p05vf6th","live":false,"duration":45,"kind":"programme"}]}},"otherSettings":{"advertisingAllowed":true,"continuousPlayCfg":{"enabled":false},"isAutoplayOnForAudience":false}}"></figure> </div> </div> </div> <figcaption class="media-with-caption__caption"><span class="off-screen">Media caption</span>Cancer blood test shows promise but more research is needed, says Prof Richard Marais</figcaption> </figure><p class="story-body__introduction">Scientists have taken a step towards one of the biggest goals in medicine - a universal blood test for cancer. </p><p>A team at Johns Hopkins University has trialled a method that detects eight common forms of the disease.</p><p>Their vision is an annual test designed to catch cancer early and save lives. UK experts said it was "enormously exciting".</p><p>However, one said more work was needed to assess the test's effectiveness at detecting early-stage cancers.</p><p>Tumours release tiny traces of their mutated DNA and proteins they make into the bloodstream. </p><div id="bbccom_mpu_1_2_3" class="bbccom_slot mpu-ad" aria-hidden="true"> <div class="bbccom_advert"> <script type="text/javascript"> /**/ (function() { if (window.bbcdotcom && bbcdotcom.adverts && bbcdotcom.adverts.slotAsync) { bbcdotcom.adverts.slotAsync('mpu', [1,2,3]); } })(); /**/ </script> </div> </div><p><a href="https://web.archive.org/web/20180130002512/http://www.bbc.co.uk/news/health-39658680" class="story-body__link">'Exciting' blood test spots cancer a year early</a></p><p><a href="https://web.archive.org/web/20180130002512/http://www.bbc.co.uk/news/health-39103629" class="story-body__link">Blood tests spot ovarian cancer early</a></p><p><a href="https://web.archive.org/web/20180130002512/http://www.bbc.co.uk/news/health-40302692" class="story-body__link">Prostate cancer blood test 'helps target treatment'</a></p><p>The CancerSEEK test looks for mutations in 16 genes that regularly arise in cancer and eight proteins that are often released. </p><p>It was trialled on 1,005 patients with cancers in the ovary, liver, stomach, pancreas, oesophagus, colon, lung or breast that had not yet spread to other tissues. </p><p>Overall, the test found 70% of the cancers. </p><p>Dr Cristian Tomasetti, from Johns Hopkins University School of Medicine, told the BBC: "This field of early detection is critical.</p><p>"I think this can have an enormous impact on cancer mortality." </p><p>The earlier a cancer is found, the greater the chance of being able to treat it.</p><p>Five of the eight cancers investigated have no screening programmes for early detection.</p><p>In some cases, the test also provided information about the tissue-of-origin of the cancer - but not all.</p><p>Pancreatic cancer has so few symptoms and is detected so late that <a href="https://web.archive.org/web/20180130002512/http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/pancreatic-cancer/survival#heading-Zero" class="story-body__link-external">four in five patients die in the year they are diagnosed</a>. </p><p>Finding tumours when they could still be surgically removed would be "a night and day difference" for survival, said Dr Tomasetti. </p><p>CancerSEEK is now being trialled in people who have not been diagnosed with cancer, which will be the real test of its usefulness. </p><p>The hope is it can complement other screening tools such as mammograms for breast cancer and colonoscopies for colorectal cancer. </p><p>Dr Tomasetti said: "We envision a blood test we could use once a year."</p><h2 class="story-body__crosshead">Universal test?</h2><p>The CancerSEEK test, reported in the journal <a href="https://web.archive.org/web/20180130002512/http://science.sciencemag.org/cgi/doi/10.1126/science.aar3247" class="story-body__link-external">Science</a>, is novel because it hunts for both the mutated DNA and the proteins. </p><p>Increasing the number of mutations and proteins being analysed would allow it to test for a wider range of cancers.</p><p>Dr Gert Attard, team leader in the Centre for Evolution and Cancer at the Institute of Cancer Research, London, and consultant medical oncologist at the Royal Marsden NHS Foundation Trust, told the BBC: "This is of massive potential.</p><figure class="media-landscape has-caption full-width"> <span class="image-and-copyright-container"> <div class="js-delayed-image-load" data-alt="breast cancer cells" data-src="https://web.archive.org/web/20180130002512oe_/https://ichef.bbci.co.uk/news/320/cpsprodpb/A9FE/production/_98681534_m1220387-breast_cancer_cells_sem-spl.jpg" data-width="976" data-height="549"></div> <span class="off-screen">Image copyright</span> <span class="story-image-copyright">Science Photo Library</span> </span> <figcaption class="media-caption"> <span class="off-screen">Image caption</span> <span class="media-caption__text"> Breast cancer can be detected by the new test </span> </figcaption> </figure><p>"I'm enormously excited. This is the Holy Grail - a blood test to diagnose cancer without all the other procedures like scans or colonoscopy."</p><p>He said "we're very close" to using blood tests to screen for cancer as "we have the technology".</p><p>But he cautioned there was still uncertainty about what to do when a cancer was diagnosed. </p><p>In some cases, the treatment may be worse than living with a cancer that is not immediately life-threatening.</p><p>Men can already have slow growing prostate cancers closely monitored rather than treated.</p><p>"When we detect cancer in a different way, we can't take for granted that everyone will need treatment," Dr Attard said.</p><h2 class="story-body__crosshead">Early stage cancers</h2><p>Prof Richard Marais, from Cancer Research UK, said it would take time to prove that it worked as an early diagnosis for cancer - at least five to six years.</p><p>"Detecting cancer early, before the disease has spread is one of the most powerful ways to improve cancer survival and this interesting research is a step towards being able to do this earlier than is currently possible." </p><p>Paul Pharoah, professor of cancer epidemiology at the University of Cambridge, said more work was needed to assess how the test performs when cancers are less advanced.</p><p>He said: "Demonstrating that a test can detect advanced cancers does not mean that the test will be useful in detecting early stage symptomatic cancer, much less pre-symptomatic cancer. The sensitivity for the stage 1 cancers in the study was only 40%."</p><p>And Dr Mangesh Thorat from the Centre for Cancer Prevention, Queen Mary University of London, said it looked promising "but with several caveats"</p><p>"A significant amount of further research is needed before we can even contemplate how this might play out in screening settings," he said. </p><p>"This is only a case-control study, and therefore needs further evaluation in large cohorts more representative of general population where such screening might be introduced."</p><p>The cost of CancerSEEK is less than $500 (£360) per patient, which is around the same price as a colonoscopy. </p><p>Follow James on <a href="https://web.archive.org/web/20180130002512/https://twitter.com/JamesTGallagher" class="story-body__link-external">twitter</a>.</p> </div> </div> <div id="comp-comments-button" data-comp-meta="{"id":"comp-comments-button","type":"comments-button","handler":"commentsButton","deviceGroups":null,"opts":{"assetId":"42736764","treatment":"ghost_column","jsEnabled":true,"commentsId":"__CPS__42736764","commentsUrl":"https:\/\/ssl.live.bbc.co.uk\/modules\/comments\/?siteId=newscommentsmodule&parentUri=http%3A%2F%2Fwww.bbc.com%2Fnews%2Fhealth-42736764%2Fcomments&forumId=__CPS__42736764&loc=en-GB&preset=responsive&title=Cancer+blood+test+%E2%80%98enormously+exciting%E2%80%99&timezone=Europe%2FLondon&isAjax=1","errormessage":"Sorry, we are unable to load the comments at this time. 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}); var loadDiscoveryLayer = function (fig) { if (fig.geo.isUK()) { require(['disco-layer'], function (discoLayer) { discoLayer.run("//web.archive.org/web/20180130002512/http://nav.files.bbci.co.uk/discovery-layer/content/", "//web.archive.org/web/20180130002512/http://nav.files.bbci.co.uk/discovery-layer/0.0.1-117.f862de7/main.css"); }); } }; var orbFig = window.orb.fig; if (typeof orbFig.load === 'function') { // Use new async API from Orbit orbFig.load(loadDiscoveryLayer); } else { // Use old sync-only API from PAL orbfig project loadDiscoveryLayer(orbFig); } } </script> <script type="text/javascript">require(["megavolt-client","istats-1","orb/cookies"],function(t,e,i){function o(){return"true"===l&&a&&t&&"function"==typeof t.getMVTIStatsLabels}function n(){!c&&o()?setTimeout(function(){e.invoke()},"500"):e.invoke()}var s=navigator.userAgent.toLowerCase(),a=!(s.indexOf("msie")>-1)||parseInt(s.split("msie")[1],10)>10,c=!1,l="true";if(i.isAllowed("s1"))try{if(o()&&t.getMVTIStatsLabels(function(t){e.addLabels(t),c=!0}),!require.s.contexts._.config.paths.idcta)return void n();require(["idcta/idcta-1"],function(t){t&&"function"==typeof t.getIStatsLabels&&e.addLabels(t.getIStatsLabels()),n()},function(t){throw t})}catch(t){console&&"function"==typeof console.log&&console.log("an exception occurred while adding idcta labels to istats, invoking istats without them",t),n()}});</script> <img alt="" id="livestats" src="https://web.archive.org/web/20180130002512im_/http://stats.bbc.co.uk/o.gif?~RS~s~RS~News~RS~t~RS~HighWeb_Story~RS~i~RS~42736764~RS~p~RS~99108~RS~a~RS~US~RS~u~RS~/news/health-42736764~RS~r~RS~0~RS~q~RS~0~RS~z~RS~3559~RS~"> </div> <script> window.old_onload = window.onload; window.onload = function() { if(window.old_onload) { window.old_onload(); } window.loaded = true; }; </script>  <script type="text/javascript"> /** CONFIGURATION START **/ var _sf_async_config = {}; _sf_async_config.uid = "50924"; _sf_async_config.domain = "www.bbc.co.uk"; _sf_async_config.sections = "News, News - health, News - STY, News - health - STY, News - news-category";  _sf_async_config.path = "bbc.co.uk/news/health-42736764"; (function() { var noCookies = true; var cookiePrefix = '_chartbeat'; if ("object" === typeof bbccookies && typeof bbccookies.readPolicy == 'function') { noCookies = !bbccookies.readPolicy().performance; } if (noCookies && document.cookie.indexOf(cookiePrefix) !== -1) { //Find and remove cookies whose names begin with '_chartbeat' var cookieSplit = document.cookie.split(';'); var cookieLength = cookieSplit.length; while (cookieLength--) { var cookie = cookieSplit[cookieLength].replace(/^\s+|\s+$/g, ''); var cookieName = cookie.split('=')[0]; if (cookieName.indexOf(cookiePrefix) === 0) { document.cookie = cookieName + '=; expires=Thu, 01 Jan 1970 00:00:00 GMT; path=/;'; } } } _sf_async_config.noCookies = noCookies; }()); /** CONFIGURATION END **/ (function(){ function loadChartbeat() { window._sf_endpt=(new Date()).getTime(); var e = document.createElement("script"); e.setAttribute("language", "javascript"); e.setAttribute("type", "text/javascript"); e.setAttribute('src', '//web.archive.org/web/20180130002512/http://static.chartbeat.com/js/chartbeat.js'); document.body.appendChild(e); } var oldonload = window.onload; window.onload = (typeof window.onload != "function") ? loadChartbeat : function() { oldonload(); loadChartbeat(); }; }()); </script>   <script> (function(){ window.bbcnewsperformance = {}; var perf = window.performance; function firstScrollTimer() { document.removeEventListener('scroll', firstScrollTimer); perf.mark('firstScroll'); perf.measure('scrolltime', 'firstScroll'); var timing = perf.getEntriesByName('scrolltime'); bbcnewsperformance.firstScrollTime = timing[0].startTime; } if (perf && perf.mark && perf.measure) { document.addEventListener('scroll', firstScrollTimer); 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Cancer blood test ‘enormously exciting’ - BBC News