Thieme E-Journals - Seminars in Thrombosis and Hemostasis / Abstract

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// custom KV example window._adexc.push([ '/506/3014/', 'ut', '_kv', { 'IpLoggedIn':'false', 'LoggedIn':'false', 'isFulltext':'false', 'JournalDoi': '00000077', } ]); var axd = document.createElement('script'); axd.type = 'text/javascript'; axd.async = 1; axd.src = "https://dmp.theadex.com/d/506/3014/s/adex.js"; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(axd, s); })(); </script>  <script src="https://polyfill.io/v3/polyfill.min.js?features=es6"></script> <script type="text/javascript" id="MathJax-script" async src="https://cdn.jsdelivr.net/npm/mathjax@3/es5/mml-chtml.js"></script> <meta name="page" content="abstract"/> <meta name="layout" content="main"/> <meta name="prism:publicationName" content="Seminars in Thrombosis and Hemostasis" /> <meta name="prism:issn" content="0094-6176" /> <meta name="prism:eissn" content="1098-9064" /> <meta name="prism:distributor" content="Thieme Medical Publishers" /> <meta name="prism:copyright" content="Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA." /> <meta name="prism:doi" content="10.1055/s-0036-1581105" /> <meta name="prism:academicField" content="Review Article" /> <meta name="prism:person" content="Francesco Dentali" /> <meta name="prism:person" content="Mark Crowther" /> <meta name="prism:person" content="Matteo Galli" /> <meta name="prism:person" content="Fulvio Pomero" /> <meta name="prism:person" content="David Garcia" /> <meta name="prism:person" content="Nathan Clark" /> <meta name="prism:person" content="Laura Spadafora" /> <meta name="prism:person" content="Daniel M. Witt" /> <meta name="prism:person" content="Walter Ageno" /> <meta name="prism:publicationDate" content="2016/05/27" /> <meta name="prism:volume" content="42" /> <meta name="prism:issueIdentifier" content="06" /> <meta name="prism:startingPage" content="671" /> <meta name="prism:endingPage" content="681" /> <meta name="prism:keyword" content="vitamin K" /> <meta name="prism:keyword" content="INR stability" /> <meta name="prism:keyword" content="diet" /> <meta name="prism:url" content="http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0036-1581105" /> <meta name="citation_language" content="en" /> <meta name="citation_journal_title" content="Seminars in Thrombosis and Hemostasis" /> <meta name="citation_journal_abbrev" content="Semin Thromb Hemost" /> <meta name="citation_issn" content="0094-6176" /> <meta name="citation_issn" content="1098-9064" /> <meta name="citation_publisher" content="Thieme Medical Publishers" /> <meta name="citation_doi" content="10.1055/s-0036-1581105" /> <meta name="citation_title" content="Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature" /> <meta name="citation_author" content="Francesco Dentali" /> <meta name="citation_author_institution" content="Department of Clinical Medicine, University of Insubria, Varese, Italy" /> <meta name="citation_author_email" content="fdentali@libero.it" /> <meta name="citation_author" content="Mark Crowther" /> <meta name="citation_author_institution" content="Departments of Medicine and Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada" /> <meta name="citation_author" content="Matteo Galli" /> <meta name="citation_author_institution" content="Department of Clinical Medicine, Tradate Hospital, Tradate, Italy" /> <meta name="citation_author" content="Fulvio Pomero" /> <meta name="citation_author_institution" content="Department of Clinical Medicine, Santa Croce and Carle General Hospital, Cuneo, Italy" /> <meta name="citation_author" content="David Garcia" /> <meta name="citation_author_institution" content="Division of Hematology, University of Washington, Seattle, Washington" /> <meta name="citation_author" content="Nathan Clark" /> <meta name="citation_author_institution" content="Kaiser Permanente Colorado Clinical Pharmacy Research Team, Aurora, Colorado" /> <meta name="citation_author" content="Laura Spadafora" /> <meta name="citation_author_institution" content="Department of Clinical Medicine, Santa Croce and Carle General Hospital, Cuneo, Italy" /> <meta name="citation_author" content="Daniel M. Witt" /> <meta name="citation_author_institution" content="Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City, Utah" /> <meta name="citation_author" content="Walter Ageno" /> <meta name="citation_author_institution" content="Department of Clinical Medicine, University of Insubria, Varese, Italy" /> <meta name="citation_author" content="for the WARPED Investigators" /> <meta name="citation_online_date" content="2016/05/27" /> <meta name="citation_publication_date" content="2016/09" /> <meta name="citation_volume" content="42" /> <meta name="citation_issue" content="06" /> <meta name="citation_firstpage" content="671" /> <meta name="citation_lastpage" content="681" /> <meta name="citation_keyword" content="vitamin K" /> <meta name="citation_keyword" content="INR stability" /> <meta name="citation_keyword" content="diet" /> <meta name="citation_pdf_url" content="http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1581105.pdf" /> <meta name="citation_fulltext_html_url" content="http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0036-1581105" /> <meta name="citation_xml_url" content="http://www.thieme-connect.de/products/ejournals/xml/10.1055/s-0036-1581105.xml" format_fulltext="schema1.3" /> <meta name="citation_abstract_html_url" content="http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1581105" /> <meta name="citation_license" content="[null, null]" /> <meta name="citation_abstract" content="<p>Vitamin K antagonists (VKA) are highly effective for the primary and secondary prevention of arterial and venous thromboembolic events. However, patients treated with VKA have on average only 60% of their international normalized ratio (INR) values within the therapeutic range and INR instability is associated with an increased risk of thrombosis and bleeding events. Recent evidence suggests that poor dietary vitamin K intake may affect anticoagulation control, but the role of vitamin K in INR stability remains to be established. We performed a systematic review of the literature to assess the role of vitamin K dietary intake on the stability of VKA and the potential effect of daily vitamin K supplementation on VKA therapy. After a search in Medline and EMBASE databases, 15 studies for a total of 1,838 patients were included in our systematic review. Observational studies suggest an increased risk of unstable anticoagulation control in patients with lower daily vitamin K intake. On the other hand, the role of daily vitamin K supplementation or a diet with controlled vitamin K content in patients on VKA treatment remains to be established. Use of daily vitamin K supplementation may be associated with a clinically relevant increase in the time in therapeutic range in patients with unstable anticoagulation control. Conversely, this effect appears small and not clinically relevant when vitamin K was administered to an unselected population receiving VKA. Other large prospective studies are necessary to confirm our preliminary findings.</p> " /> <meta name="dc:medium" content="Seminars in Thrombosis and Hemostasis" /> <meta name="dc:language" content="en" /> <meta name="dc:rights" content="Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA." /> <meta name="dc:publisher" content="Thieme Medical Publishers" /> <meta name="dc:identifier" content="10.1055/s-0036-1581105" /> <meta name="dc:subject" content="Review Article" /> <meta name="dc:title" content="Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature" /> <meta name="dc:creator" content="Francesco Dentali" /> <meta name="dc:creator" content="Mark Crowther" /> <meta name="dc:creator" content="Matteo Galli" /> <meta name="dc:creator" content="Fulvio Pomero" /> <meta name="dc:creator" content="David Garcia" /> <meta name="dc:creator" content="Nathan Clark" /> <meta name="dc:creator" content="Laura Spadafora" /> <meta name="dc:creator" content="Daniel M. Witt" /> <meta name="dc:creator" content="Walter Ageno" /> <meta name="dc:creator" content="for the WARPED Investigators" /> <meta name="dc:date" content="2016/05/27" /> <meta name="dcterms:abstract" content="Vitamin K antagonists (VKA) are highly effective for the primary and secondary prevention of arterial and venous thromboembolic events. However, patients treated with VKA have on average only 60% of their international normalized ratio (INR) values within the therapeutic range and INR instability is associated with an increased risk of thrombosis and bleeding events. Recent evidence suggests that poor dietary vitamin K intake may affect anticoagulation control, but the role of vitamin K in INR stability remains to be established. We performed a systematic review of the literature to assess the role of vitamin K dietary intake on the stability of VKA and the potential effect of daily vitamin K supplementation on VKA therapy. After a search in Medline and EMBASE databases, 15 studies for a total of 1,838 patients were included in our systematic review. Observational studies suggest an increased risk of unstable anticoagulation control in patients with lower daily vitamin K intake. On the other hand, the role of daily vitamin K supplementation or a diet with controlled vitamin K content in patients on VKA treatment remains to be established. Use of daily vitamin K supplementation may be associated with a clinically relevant increase in the time in therapeutic range in patients with unstable anticoagulation control. Conversely, this effect appears small and not clinically relevant when vitamin K was administered to an unselected population receiving VKA. Other large prospective studies are necessary to confirm our preliminary findings. 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var request = $.ajax({ type : 'GET', dataType : 'json', async : true, cache: false, url : url, success : function(data) { } }); } </script> </div>   <div class="articleHeader"> <div xmlns:m="http://www.w3.org/1998/Math/MathML" xmlns:exsl="http://exslt.org/common" class="doi">Semin Thromb Hemost 2016; 42(06): 671-681<br>DOI: 10.1055/s-0036-1581105</div> <div class="articleType"> <div>Review Article</div> </div> <span class="articleCategories">Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.</span> <h1>Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature</h1> <span id="authorlist"><span class="author"> <div class="name">Francesco Dentali</div> <div class="affiliation"> <sup>1   </sup>Department of Clinical Medicine, University of Insubria, Varese, Italy</div> <div class="affiliation"></div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">Mark Crowther</div> <div class="affiliation"> <sup>2   </sup>Departments of Medicine and Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada</div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">Matteo Galli</div> <div class="affiliation"> <sup>3   </sup>Department of Clinical Medicine, Tradate Hospital, Tradate, Italy</div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">Fulvio Pomero</div> <div class="affiliation"> <sup>4   </sup>Department of Clinical Medicine, Santa Croce and Carle General Hospital, Cuneo, Italy</div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">David Garcia</div> <div class="affiliation"> <sup>5   </sup>Division of Hematology, University of Washington, Seattle, Washington</div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">Nathan Clark</div> <div class="affiliation"> <sup>6   </sup>Kaiser Permanente Colorado Clinical Pharmacy Research Team, Aurora, Colorado</div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">Laura Spadafora</div> <div class="affiliation"> <sup>4   </sup>Department of Clinical Medicine, Santa Croce and Carle General Hospital, Cuneo, Italy</div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">Daniel M. Witt</div> <div class="affiliation"> <sup>7   </sup>Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City, Utah</div> <div class="authorseparator">, </div> </span><span class="author"> <div class="name">Walter Ageno</div> <div class="affiliation"> <sup>1   </sup>Department of Clinical Medicine, University of Insubria, Varese, Italy</div> <div class="authorseparator">, </div> </span> <collab-name xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">for the WARPED Investigators</collab-name> <a class="toggle-affiliation-infos" href="#">&rsaquo; Author Affiliations<span class="verbum"></span></a></span> <div class="toggleMenu articleToggleMenu"> <div class="toggleButton">Further Information<div class="toggleContent"> <div class="wrapper twoCols"> <div class="col"> <h3>Publication History</h3> <p>Publication Date:<br>27 May 2016 (online)</p> </div> </div> </div> </div> </div> </div><ul class="tabBar borderBottom" id="articleTabs"> <li class="tab active"> <a href="#abstract">Abstract</a> </li> <li class="tab"> <a href="/products/ejournals/html/10.1055/s-0036-1581105">Full Text</a> </li> <li class="tab"> <a href="#references">References</a> </li> </ul><div id="sections"> <section id="abstract"> <div class="articleFunctions"> <input value="ai10.1055/s-0036-1581105,10.1055/s-0036-1581105" name="ai" type="hidden"> <div style="display: none" id="sfx10.1055/s-0036-1581105"> <a id="sfxServer" data-href="?id=doi:10.1055/s-0036-1581105&sid=Thieme:Connect&jtitle=Seminars in Thrombosis and Hemostasis&issue=06&volume=42&date=2016&issn=0094-6176&spage=671&epage=681&aulast=Dentali&aufirst=Francesco&__char_set=utf8&atitle=Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature" target="sfx"><span class="articleAccessLabel sfx"><img id="sfxImageUrl" src="" alt="SFX Search" height="15" width="52"></span></a> </div> <a style="display: none" href="/products/ejournals/buyDocument/10.1055/s-0036-1581105" class="gotoLink" id="sasLink">Buy Article</a> <a onClick="RightslinkPopUp("1098-9064", "Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature", "05/27/2016", "Francesco Dentali, Mark Crowther, Matteo Galli, Fulvio Pomero, David Garcia, Nathan Clark, Laura Spadafora, Daniel M. Witt, Walter Ageno, ", "", "10.1055/s-0036-1581105", "671", "681", "42", "06", "")" class="gotoLink" href="javascript:;">Permissions and Reprints</a> </div> <figure style="margin-left: 30px" class="floatRight"> <a data-doi="10.1055/s-0036-1581105" data-caption="" data-id="10-1055-s-0036-1581105_02324-1.jpg" data-cssClass="previewOverlay" href="https://www.thieme-connect.de/media/sth/201606/lookinside/10-1055-s-0036-1581105_02324-1.jpg" class="zoomFunction alignLeft"><img src="https://www.thieme-connect.de/media/sth/201606/lookinside/thumbnails/10-1055-s-0036-1581105_02324-1.jpg"></a> <figcaption></figcaption> </figure> <p> <a name="N10D14"></a> <h3>Abstract</h3> <p>Vitamin K antagonists (VKA) are highly effective for the primary and secondary prevention of arterial and venous thromboembolic events. However, patients treated with VKA have on average only 60% of their international normalized ratio (INR) values within the therapeutic range and INR instability is associated with an increased risk of thrombosis and bleeding events. Recent evidence suggests that poor dietary vitamin K intake may affect anticoagulation control, but the role of vitamin K in INR stability remains to be established. We performed a systematic review of the literature to assess the role of vitamin K dietary intake on the stability of VKA and the potential effect of daily vitamin K supplementation on VKA therapy. After a search in Medline and EMBASE databases, 15 studies for a total of 1,838 patients were included in our systematic review. Observational studies suggest an increased risk of unstable anticoagulation control in patients with lower daily vitamin K intake. On the other hand, the role of daily vitamin K supplementation or a diet with controlled vitamin K content in patients on VKA treatment remains to be established. Use of daily vitamin K supplementation may be associated with a clinically relevant increase in the time in therapeutic range in patients with unstable anticoagulation control. Conversely, this effect appears small and not clinically relevant when vitamin K was administered to an unselected population receiving VKA. Other large prospective studies are necessary to confirm our preliminary findings.</p> </p> <i></i><i></i> <div class="articleKeywords"> <a name="N10D1F"></a> <h3>Keywords</h3> vitamin K - INR stability - diet </div> <div id="trendmd-suggestions"></div> </section> <section id="htmlfulltext"> </section> <section id="references"> <a name=""></a> <ul class="literaturliste"> <a name="N11A59"></a> <li> <h3>References</h3> </li> <li> <a name="JR02324-1"></a><strong>1</strong> Kakkar AK, Mueller I, Bassand JP , et al; GARFIELD Registry Investigators. Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: perspectives from the international, observational, prospective GARFIELD registry. 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// URL zum Abholen der Ausgaben zusammenbauen var url = jsContextPath + '/json/issues?shortname=' + shortname + '&year=' + year; // Request vorbereiten var xmlHttp = null; // Mozilla, Opera, Safari sowie Internet Explorer (ab v7) if (typeof XMLHttpRequest != 'undefined') { xmlHttp = new XMLHttpRequest(); } if (!xmlHttp) { // Internet Explorer 6 und älter try { xmlHttp = new ActiveXObject("Msxml2.XMLHTTP"); } catch (e) { try { xmlHttp = new ActiveXObject("Microsoft.XMLHTTP"); } catch (e) { xmlHttp = null; } } } // URL abschicken und Dropdownbox fuellen if (xmlHttp) { xmlHttp.open('GET', url, true); xmlHttp.onreadystatechange = function() { if (xmlHttp.readyState == 4) { var issues = eval('(' + xmlHttp.responseText + ')'); if (isDisplayVolume == true) { if (issues.length > 1) { var showVolume = false; var comparedIssue = null; var ids = []; for (var i = 0; i < issues.length; i++) { if (issues[i]['number'].indexOf('S ') > -1 || issues[i]['number'].toLowerCase() == issues[i]['number'].toUpperCase()) { if (comparedIssue == null) { comparedIssue = issues[i]; 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Thieme E-Journals - Seminars in Thrombosis and Hemostasis / Abstract