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Deep Brain Stimulation for Obsessive-Compulsive Disorder | Psychiatric Annals

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Provide an overview of the history and origins of deep brain stimulation (DBS) for treatment-refractory obsessive-compulsive disorder (OCD). 2. Describe the various neuroanatomic targets of DBS implant for OCD as well as the neurocircuitry involved. 3. Explain the effects of DBS for OCD, both intended and unintended, as well as the promise the treatment holds "/><meta id="metaKeywords" name="keywords" content="Psychiatric Annals,Psychiatry,Obsessive-Compulsive Disorder,CME"/><meta id="Meta1" name="scID"/><meta id="scID" name="scID"/><meta name="designator" content="cme"/> <meta name="designators" content="cme"/> <meta name="PostedDate" content="2013-08-15"/> <meta name="specialties" content="Psychiatry"/> <meta name="specialty" content="Psychiatry"/> <meta name="primary_specialty" content="Psychiatry"/> <meta name="subspecialties" content="Obsessive-Compulsive Disorder"/> <meta name="subspecialty" content="Obsessive-Compulsive Disorder"/> <meta name="departments" content="CME"/> <meta name="department" content="CME"/> <meta name="content_type" content="Journal Article"/> <meta name="pageid" content="{1801F9CB-92C9-468C-B5DE-D519665F6C86}"/> <meta property="og:image" content="https://web.archive.org/web/20130912220906im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/healio_safe_image.png"/><meta name="pubabbv" content="PsycAnn"/><meta name="authors" content="Andrew K. 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Arulpragasam, BS, BA"/><meta name="author" content=" Navneet Kaur, BS"/><meta name="author" content=" Thilo Deckersbach, PhD"/><meta name="author" content=" Cristina Cusin, MD"/> <!-- Begin CSS --> <link href="https://web.archive.org/web/20130912220906cs_/http://c341130.r30.cf1.rackcdn.com/styles.css" rel="stylesheet" type="text/css"/> <!--<link href="http://c341130.r30.cf1.rackcdn.com/styles.css" rel="stylesheet" type="text/css" />--> <link href="https://web.archive.org/web/20130912220906cs_/http://c341130.r30.cf1.rackcdn.com/styles2.css" rel="stylesheet" type="text/css"/><link href="https://web.archive.org/web/20130912220906cs_/http://c341130.r30.cf1.rackcdn.com/tb-ec-lb-min.css" rel="stylesheet" type="text/css" media="screen"/><link href="https://web.archive.org/web/20130912220906cs_/http://0043b493b06d545127da-d7c71b4c9ba1dd44e0cf6fa474e637d7.r99.cf1.rackcdn.com/healiojobs.css" rel="stylesheet" type="text/css"/><link href="https://web.archive.org/web/20130912220906cs_/http://6af4390358a281e0b439-028b17272c3ee5c2953a93a8c54187e2.r22.cf1.rackcdn.com/MediaKits.css" rel="stylesheet" type="text/css"/> <!--[if !IE 7]><style type="text/css">#wrap {display:table;height:100%}</style><![endif]--> <link rel="shortcut icon" type="image/x-icon" href="https://web.archive.org/web/20130912220906im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/favicon.ico"/> <style type="text/css"> #wrap:before, #wrap:after { content: " "; display: table; } #wrap:after { clear: both; } </style> <script type="text/javascript" language="javascript" src="https://web.archive.org/web/20130912220906js_/http://ajax.googleapis.com/ajax/libs/jquery/1.8.2/jquery.min.js"></script> <script type="text/javascript" language="javascript" src="https://web.archive.org/web/20130912220906js_/http://cdn.jquerytools.org/1.2.7/full/jquery.tools.min.js"></script> <script type="text/javascript" language="javascript">$j = $.noConflict();</script> <script type="text/javascript" language="javascript" src="https://web.archive.org/web/20130912220906js_/http://c341136.r36.cf1.rackcdn.com/thickbox-compressed.js"></script> <script type="text/javascript"> var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; (function() { var gads = document.createElement('script'); gads.async = true; gads.type = 'text/javascript'; var useSSL = 'https:' == document.location.protocol; gads.src = (useSSL ? 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/breadcrumbs --> <!-- related links --> <!--googleoff: index--><div id="SeeAlso" class="related-links"><h3>See Also</h3><ul><li><a href="https://web.archive.org/web/20130912220906/http://www.healio.com/psychiatry/journals/psycann/%7B6ae769ea-a512-4d5e-8c59-b69ee95cf57f%7D/nature-nurture-and-deep-brain-stimulation">Nature, Nurture, and Deep Brain Stimulation</a></li><li><a href="https://web.archive.org/web/20130912220906/http://www.healio.com/psychiatry/journals/psycann/%7Baee10d8a-5b49-436f-a8ff-31293e22e3c4%7D/diagnosis-and-treatment-of-sports-related-traumatic-brain-injury">Diagnosis and Treatment of Sports-Related Traumatic Brain ...</a></li><li><a href="https://web.archive.org/web/20130912220906/http://www.healio.com/psychiatry/journals/psycann/%7B0439bd6b-a182-4481-887d-a4c1a87b8d20%7D/this-issue-deep-brain-stimulation">This issue: Deep Brain Stimulation</a></li></ul></div><!-- /related links --><!--googleon: index> <!-- /related links --> <input name="layout_0$maincontent_0$seeAlsoInsertUnderParagraph" type="hidden" id="layout_0_maincontent_0_seeAlsoInsertUnderParagraph" value="1"/> <div class="journals-content"><div class="journal-tab-group"><ul class="journal-tabs"><li><a href="/web/20130912220906/http://www.healio.com/journals/psycann">Current Issue</a></li><li><a href="/web/20130912220906/http://www.healio.com/journals/psycann/m/past-issues">Past Issues</a></li></ul><div class="journal-panes"><div class="abstract-content"><p class="kicker-top">CME&nbsp;</p><h2><a href="#">Deep Brain Stimulation for Obsessive-Compulsive Disorder</a></h2><p class="authors">Andrew K. Corse, BA; Tina Chou, BA; Amanda R. Arulpragasam, BS, BA; Navneet Kaur, BS; Thilo Deckersbach, PhD; Cristina Cusin, MD</p><div class="journal-info"><ul class="full-text"><li class="header">Read Full Text Article</li><li class="html"><a class="active" title="View Html Version" alt="View Html Version" rel="nofollow" href="/web/20130912220906/http://www.healio.com/buy-journal-or-article?a={1801F9CB-92C9-468C-B5DE-D519665F6C86}&amp;amp;returnUrl=%2fpsychiatry%2fjournals%2fpsycann%2f%7b1801f9cb-92c9-468c-b5de-d519665f6c86%7d%2fdeep-brain-stimulation-for-obsessive-compulsive-disorder&amp;amp;jrnl=J0213">Html Icon</a></li><li class="pdf"><a id="pdf" href="/web/20130912220906/http://www.healio.com/buy-journal-or-article?a={1801F9CB-92C9-468C-B5DE-D519665F6C86}&amp;amp;returnUrl=%2fpsychiatry%2fjournals%2fpsycann%2f%7b1801f9cb-92c9-468c-b5de-d519665f6c86%7d%2fdeep-brain-stimulation-for-obsessive-compulsive-disorder'%3Fpdf%3D1'&amp;amp;jrnl=J0213" class="active" title="View Pdf Version" alt="View Pdf Version" rel="nofollow">Pdf Icon</a></li></ul><ul class="article-citation"><li>Psychiatric Annals</li><li>August 2013 - Volume 43 &middot; Issue 8: 351-357</li><li class="doi">DOI: 10.3928/00485713-20130806-03</li></ul></div><div class="copyrights" style="float:right;"><a onclick="RightsLinkPopUpV2();" href="#"><img alt="Rights and Permissions" title="Rights and Permissions" border="0" src="https://web.archive.org/web/20130912220906im_/http://213a1ca8842e5e699a80-05ce35571e92a3f7383a191aa5840bba.r66.cf1.rackcdn.com/request-permissions.gif"></img></a><script type="text/javascript" language="javascript">function RightsLinkPopUpV2() { var location="https://web.archive.org/web/20130912220906/https://s100.copyright.com/AppDispatchServlet?publisherName=slack&publication=0048-5713&contentID=10.3928/00485713-20130806-03&publicationDate=2013&copyright=Copyright%20%26copy%3B%202013%2C%20Slack%20Inc.&title=Deep%20Brain%20Stimulation%20for%20Obsessive-Compulsive%20Disorder&volumeNum=43&issueNum=8&author=Andrew%20K.%20Corse%2C%20BA%3B%20Tina%20Chou%2C%20BA%3B%20Amanda%20R.%20Arulpragasam%2C%20BS%2C%20BA%3B%20Navneet%20Kaur%2C%20BS%3B%20Thilo%20Deckersbach%2C%20PhD%3B%20Cristina%20Cusin%2C%20MD%26orderBeanReset%3DTRUE"; window.open(location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); } </script></div><div class="article-tab-group"><ul class="article-tabs"><li><a id="anchor-tab-abstract" href="#">Abstract</a></li><li><a id="anchor-tab-article" href="/web/20130912220906/http://www.healio.com/buy-journal-or-article?a={1801F9CB-92C9-468C-B5DE-D519665F6C86}&amp;amp;returnUrl=%2fpsychiatry%2fjournals%2fpsycann%2f%7b1801f9cb-92c9-468c-b5de-d519665f6c86%7d%2fdeep-brain-stimulation-for-obsessive-compulsive-disorder'%3Ffulltext%3D1'&amp;amp;jrnl=J0213">Article</a></li><li><a id="anchor-tab-figures" href="/web/20130912220906/http://www.healio.com/buy-journal-or-article?a={1801F9CB-92C9-468C-B5DE-D519665F6C86}&amp;amp;returnUrl=%2fpsychiatry%2fjournals%2fpsycann%2f%7b1801f9cb-92c9-468c-b5de-d519665f6c86%7d%2fdeep-brain-stimulation-for-obsessive-compulsive-disorder'%3Ffulltext%3D1'&amp;amp;jrnl=J0213">Figures/Tables</a></li><li class="last"><a id="anchor-tab-refs" href="/web/20130912220906/http://www.healio.com/buy-journal-or-article?a={1801F9CB-92C9-468C-B5DE-D519665F6C86}&amp;amp;returnUrl=%2fpsychiatry%2fjournals%2fpsycann%2f%7b1801f9cb-92c9-468c-b5de-d519665f6c86%7d%2fdeep-brain-stimulation-for-obsessive-compulsive-disorder'%3Ffulltext%3D1'&amp;amp;jrnl=J0213">References</a></li><li class="cite-link"><a href="#" onclick="showCitation();">Get Citation</a><script type="text/javascript">function showCitation() {var w = window.open('', '', 'width=400,height=400,resizeable,scrollbars');w.document.write('Corse A, Chou T, Arulpragasam A, Kaur N, Deckersbach T, Cusin C. Deep Brain Stimulation for Obsessive-Compulsive Disorder. <i>Psychiatr Ann.</i> 2013; 43: 351-357. doi: 10.3928/00485713-20130806-03 <a href="https://web.archive.org/web/20130912220906/http://www.healio.com/psychiatry/journals/psycann/{1801f9cb-92c9-468c-b5de-d519665f6c86}/deep-brain-stimulation-for-obsessive-compulsive-disorder">[link]</a>');w.document.close(); }</script></li></ul></div><div id="abstractPortion"><h4>Abstract</h4><div class="ftSection"> <strong> <span class="ftInlineSubsectionTitle">CME Educational Objectives</span> </strong> <label></label> <p>1. Provide an overview of the history and origins of deep brain stimulation (DBS) for treatment-refractory obsessive-compulsive disorder (OCD).</p> <label>2.</label> Describe the various neuroanatomic targets of DBS implant for OCD as well as the neurocircuitry involved.</p> <label></label> <p>3. Explain the effects of DBS for OCD, both intended and unintended, as well as the promise the treatment holds for select treatment-resistant OCD patients.</p> </div> <p class="ftSection"> </p> <p>Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder that affects approximately 2% to 3% of the population. OCD is characterized by persistent, intrusive, and distressing thoughts (obsessions) and ritualistic behaviors (compulsions), such as counting, organizing, or cleaning, which are used to lessen anxiety caused by the obsessive thoughts. The symptoms of OCD generally manifest in childhood or adolescence and may result in significant impairment in everyday functioning. The etiology of OCD is hypothesized to involve a combination of genetic and environmental factors.</p></div><h5>Authors</h5><p>Andrew K. Corse, BA, is Clinical Research Coordinator, Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital. Tina Chou, BA, is a graduate student within the Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, and Department of Psychology, Harvard University. Amanda R. Arulpragasam, BS, BA, is Clinical Research Coordinator, Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital. Navneet Kaur, BS, is Clinical Research Coordinator, Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital. Thilo Deckersbach, PhD, is Director of Research, Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, Associate Professor, Harvard Medical School. Cristina Cusin, MD, is Instructor, Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School and Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School.</p> <p>Address correspondence to: Cristina Cusin, MD, Depression Clinical and Research Program, Massachusetts General Hospital, One Bowdoin Square, Suite 634, Boston, MA 02114; email: ccusin@partners.org.</p> <p>Disclosure: The authors have no relevant financial relationships to disclose.</p><p>10.3928/00485713-20130806-03</p></div></div></div></div> <div class="social-links"> <div class="fb-like" data-send="false" data-width="300" data-show-faces="true" data-action="recommend"></div> <ul class="share"> <li><a href="javascript:void(0)" id="twitter" class="twitter-link" target="_new">Tweet</a></li> <li><a href="javascript:void(0)" id="facebook" class="facebook-link" target="_new">Share</a></li> <li class="linkedin"><a href="javascript:void(0)" id="linkedin" class="linkedin-link">Link</a></li> <li><span class="db-wrapper"><span class="g-plusone" data-size="tall" data-annotation="none"></span></span></li> <li><a href="javascript:void(0)" id="email">Email</a></li> <li class="last"><a href="javascript:void(0)" id="print">Print</a></li> </ul> <input name="layout_0$maincontent_1$SocialMedia$articleItemForTweet" type="hidden" id="layout_0_maincontent_1_SocialMedia_articleItemForTweet" value="{1801F9CB-92C9-468C-B5DE-D519665F6C86}"/> </div> <!-- comment form --> <div id="respond"> <h4> Comments</h4> <script language="javascript" type="text/javascript"> var idcomments_acct = 'aa6ff53f9870e40f92f83e1b5df3cddf'; var idcomments_post_id = 'ac60939f-ce47-4a26-8926-b0df2ad05a09'; var idcomments_post_url; </script> <span id="IDCommentsPostTitle" style="display: none"></span> <script type="text/javascript" src="https://web.archive.org/web/20130912220906js_/http://www.intensedebate.com/js/genericCommentWrapperV2.js"></script> <p class="comment-notes"> Healio is intended for health care provider use and all comments will be posted at the discretion of the editors. 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