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Jay Levy, MD | UCSF Helen Diller Family Comprehensive Cancer Center

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Levy, MD </h1> <strong> Professor in Residence, Department of Medicine, UCSF </strong> <div class="people-callout__memberships"> <h2 class="people-callout__memberships-title">Cancer Center Program Membership</h2> <a href="/research/programs/affiliate">Affiliate Member</a> </div> </div> </div> <div class="column-4 sidebar last"> <div class="widget widget--people-details"> <div class="widget__content"> <p class="contact-info contact-info--phone"> <strong> <a href="/cdn-cgi/l/email-protection#a0cac1d98eccc5d6d9e0d5c3d3c68ec5c4d5"> <span class="__cf_email__" data-cfemail="147e756d3a7871626d54617767723a717061">[email&#160;protected]</span> </a> </strong> </p> <p> <strong>Phone:</strong> <a href="tel:%28415%29476-4071%28voice%29">(415) 476-4071 (voice)</a> </p> <div class="field field-address-postal field--type-address field--label-hidden field__item"> <p class="address" translate="no"> Box 1270, UCSF <br> San Francisco, CA 94143-1270 </p> </div> <p> <a class="button button--dark-blue" href="https://profiles.ucsf.edu/jaya.levy"> UCSF Profiles </a> </p> <a href="https://levylab.ucsf.edu/" class="button button--dark-blue"> Lab Site </a> </div> </div> </div> </article> </div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockperson-header-person-tabs-block" id="block-views-block-person-header-tabs-block"> <div block="block-views-block-person-header-tabs-block" region="content_header"><div class="view view-person-header view-id-person_header view-display-id-person_tabs_block js-view-dom-id-e91559a907f55e191b941d1c60e84166a7e470690c997bcaa97461e770a61f99"> <div class="view-content"> <div class="views-row"> <section about="/people/levy.jay" class="node node--type-kanopi-ucsf-person node--view-mode-default"> <div class="profile-tabs"> <div class="profile-tab-nav"> <ul> <li><a href="#research" class="active">Research</a></li> <li><a href="#education">Training</a></li> <li><a href="#honors">Awards</a></li> <li><a href="#publications">Publications</a></li> </ul> </div> </div> </section> </div> </div> </div> </div> </div> </section> </div> <a id="main-content" tabindex="-1"></a> <div class="column-8 content"> <div id="block-mainpagecontent" class="block block-system block-system-main-block"> <article about="/people/levy.jay" class="node node--type-kanopi-ucsf-person node--view-mode-full"> <div class="node__content content"> <div class="column-8 content"> <div class="profile-tab-container"> <div class="profile-tab profile-tab-active" id="research"> <div class="profile-tab-item"> <h3>Research Summary</h3> Research in the Levy laboratory is directed at understanding the interaction of viruses and the immune system in microbial pathogenesis. It focuses on HIV infection with the goal of designing novel antiviral therapies and an effective AIDS vaccine for which both innate and adaptive responses are needed. Biologic, serologic, and molecular characterization of several HIV-1 and HIV-2 strains has revealed their extensive heterogeneity and how viruses can evolve differently in the same individual in the immune system, bowel, and the brain. A major emphasis in the laboratory has been on anti-HIV innate immune responses. The research group is evaluating the role of plasmacytoid dendritic cells (PDC), the main producers of type 1 interferons. Studies are directed at understanding how HIV-infected cells induce interferon production from PDC and what cell surface molecules, including toll-like receptors (TLR), are involved in this process. An important potent innate response we have discovered is the ability of CD8+ lymphocytes to suppress HIV replication without killing the cells. This novel CD8+ cell noncytotoxic antiviral response (CNAR) is mediated by an as yet unidentified, natural CD8+ cell antiviral factor (CAF) that blocks HIV transcription. In summary, the Levy laboratory has been conducting studies to identify CAF through RNA Seq procedures, to determine the best strategy for an AIDS vaccine and to use genetically modified stem cell approaches towards a potential HIV cure. </div> <div class="profile-tab-item"> <h3>Research Funding</h3> <ul class="list-no-disc"> <li><div> March 6, 2017 - February 28, 2020 - Characterization of a New Anti-HIV Immune Protein , Principal Investigator . Sponsor: NIH/NIAID, Sponsor Award ID: R21AI129685</div></li> <li><div> May 1, 2014 - April 30, 2018 - HIV Cure with CCr5 (-) Human IPS Hematopoietic Stem Cells , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI102825</div></li> <li><div> March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614</div></li> <li><div> June 7, 2012 - August 31, 2013 - HIV cure with CCR5 (-) human IPS hematopoietic stem cells , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56AI102825</div></li> </ul> </div> </div> <div class="profile-tab" id="education"> <h3>Education</h3> <p>Wesleyan University, Middletown, CT, BA, 1960, Biology<br />Universite de Paris, France, 1961, Regeneration<br />Columbia University, New York, MD, 1965, Medicine and Virology</p> </div> <div class="profile-tab" id="honors"> <h3>Honors & Awards</h3> <ul> <li>UCSF 150th Anniversary Alumni Award, University of California, San Francisco, 2015</li> <li>Gold Medal for Excellence in Medical Research, Columbia University, 2008</li> <li>Fellow, American Academy of Arts and Sciences, 2004</li> <li>Fellow, American Academy of Microbiology, 2003</li> <li>UCSF 45th Faculty Research Lecturer, University of California, San Francisco, 2002</li> <li>Doctor of Science Honorary Degree, Wesleyan University, 1996</li> <li>Fellow, American Association for the Advancement of Science, 1993</li> </ul> </div> <div class="profile-tab" id="publications"> <h3>Selected Publications</h3> <ol> <li> Morvan MG, Teque F, Ye L, Moreno ME, Wang J, VandenBerg S, Stoddart CA, Kan YW, Levy JA. Genetically edited CD34+ cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells. Proc Natl Acad Sci U S A. 2021 05 18; 118(20). &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/33975958" target="_blank">View on PubMed</a> </li> <li> Morvan MG, Teque FC, Locher CP, Levy JA. The CD8+ T Cell Noncytotoxic Antiviral Responses. Microbiol Mol Biol Rev. 2021 05 19; 85(2). &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/33980586" target="_blank">View on PubMed</a> </li> <li> Levy JA, Coutinho RA, Saag MS. AIDS new editor announcement. AIDS. 2020 11 15; 34(14):1995. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/32947591" target="_blank">View on PubMed</a> </li> <li> Levy JA. The need to reassess our approaches at HIV cure and prevention. AIDS. 2020 11 15; 34(14):2141-2143. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/32991381" target="_blank">View on PubMed</a> </li> <li> Ye L, Wang J, Teque F, Xie F, Tan Y, Kan YW, Levy JA. Generation of HIV-1-infected patients&#039; gene-edited induced pluripotent stem cells using feeder-free culture conditions. AIDS. 2020 07 01; 34(8):1127-1139. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/32501846" target="_blank">View on PubMed</a> </li> <li> Teque F, Ye L, Xie F, Wang J, Morvan MG, Kan YW, Levy JA. Genetically-edited induced pluripotent stem cells derived from HIV-1-infected patients on therapy can give rise to immune cells resistant to HIV-1 infection. AIDS. 2020 07 01; 34(8):1141-1149. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/32287059" target="_blank">View on PubMed</a> </li> <li> Hecht FM, Moskowitz JT, Moran P, Epel ES, Bacchetti P, Acree M, Kemeny ME, Mendes WB, Duncan LG, Weng H, Levy JA, Deeks SG, Folkman S. A randomized, controlled trial of mindfulness-based stress reduction in HIV infection. Brain Behav Immun. 2018 10; 73:331-339. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/29842903" target="_blank">View on PubMed</a> </li> <li> Levy JA, Murphy EL. Schwab M (ed.) Encyclopedia of Cancer. Human T-Lymphotropic Virus. 2017; 3:2146 - 2149. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/" target="_blank">View on PubMed</a> </li> <li> Blazek D, Teque F, Mackewicz C, Peterlin M, Levy JA. The CD8+ cell non-cytotoxic antiviral response affects RNA polymerase II-mediated human immunodeficiency virus transcription in infected CD4+ cells. J Gen Virol. 2016 Jan; 97(1):220-224. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/26499373" target="_blank">View on PubMed</a> </li> <li> Levy JA. Discovery of another anti-HIV protein in the search for the CD8+ cell anti-HIV Factor. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):7888-9. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/26085138" target="_blank">View on PubMed</a> </li> <li> Levy JA. Dispelling myths and focusing on notable concepts in HIV pathogenesis. Trends Mol Med. 2015 Jun; 21(6):341-53. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/25883070" target="_blank">View on PubMed</a> </li> <li> Roff SR, Sanou MP, Rathore MH, Levy JA, Yamamoto JK. Conserved epitopes on HIV-1, FIV and SIV p24 proteins are recognized by HIV-1 infected subjects. Hum Vaccin Immunother. 2015; 11(6):1540-56. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/25844718" target="_blank">View on PubMed</a> </li> <li> Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5螖32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9591-6. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/24927590" target="_blank">View on PubMed</a> </li> <li> Venditto VJ, Wieczorek L, Molnar S, Teque F, Landucci G, Watson DS, Forthal D, Polonis VR, Levy JA, Szoka FC. Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits. Clin Vaccine Immunol. 2014 Aug; 21(8):1086-93. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/24872518" target="_blank">View on PubMed</a> </li> <li> Sanou MP, Roff SR, Mennella A, Sleasman JW, Rathore MH, Yamamoto JK, Levy JA. Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects. 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