La creatina fa male? Ecco (TUTTI) i possibili effetti collaterali

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type='text/css'>.rp4wp-related-posts ul{width:100%;padding:0;margin:0;float:left;} .rp4wp-related-posts ul>li{clear:both;} .rp4wp-related-posts ul>li>p{margin:0;padding:0;} .rp4wp-related-post-image{width:35%;padding-right:25px;-moz-box-sizing:border-box;-webkit-box-sizing:border-box;box-sizing:border-box;float:left;}</style> <script type="application/ld+json">{"@context":"http:\/\/schema.org","@type":"Article","dateModified":"2025-01-31T08:19:18+01:00","author":{"@type":"Person","name":"Dr. Roberto Gindro","description":"Laurea in Farmacia con lode, PhD in Scienza delle sostanze bioattive.\r\n\r\nFondatore del sito, si occupa ad oggi della supervisione editoriale e scientifica."},"headline":"La creatina fa male? Ecco (TUTTI) i possibili effetti collaterali","url":"https:\/\/healthy.thewom.it\/integratori\/creatina-effetti-collaterali\/","datePublished":"2025-01-21T09:34:35+01:00","mainEntityOfPage":{"@type":"WebPage","@id":"https:\/\/healthy.thewom.it\/integratori\/creatina-effetti-collaterali\/"},"publisher":{"@type":"Organization","name":"Healthy The Wom","logo":{"@type":"ImageObject","url":"https:\/\/healthy.thewom.it\/wp-content\/uploads\/2023\/05\/TheWomBolloHealty.png","width":1001,"height":1001}},"articleBody":"La creatina \u00e8 diventata uno degli integratori alimentari pi\u00f9 utilizzati, apprezzata sia da atleti che da persone con condizioni cliniche specifiche (con recenti studi che ne hanno indagato gli effetti positivi sul cervello).\r\n\r\nMa \u00e8 davvero sicura? Nessun integratore \u00e8 mai completamente scevro da rischi (nemmeno la creatina), ma l'attuale letteratura scientifica ne supporta un elevato grado di sicurezza quando assunta alle dosi raccomandate.\r\n\r\nAnalizziamo in modo critico l'attuale letteratura, ricordando per\u00f2 che in caso di dubbi (soprattutto nel caso di patologie preesistenti) \u00e8 indispensabile il parere del proprio medico.\r\n\r\n\r\nEffetti collaterali dimostrati\r\nTra gli effetti collaterali pi\u00f9 comuni si annoverano:\r\n\r\n \tRitenzione idrica: \u00e8 l'effetto pi\u00f9 frequente, poich\u00e9 la creatina attira l'acqua nei muscoli. Questo pu\u00f2 causare un aumento temporaneo del peso corporeo (ma questo NON \u00e8 un male, anzi!, vedi sotto nel paragrafo dedicato).\r\n \tDisturbi gastrointestinali: alcuni individui possono sperimentare crampi allo stomaco, nausea o diarrea, specialmente nelle fasi iniziali dell'integrazione.\r\n\r\nPi\u00f9 raramente sono invece stati segnalati\r\n\r\n \tCrampi muscolari: sono stati aneddoticamente riportati da alcuni soggetti. Vedere sotto per una trattazione pi\u00f9 completa.\r\n\r\nDisturbi gastrointestinali (nausea, diarrea, ...)\r\nLa creatina pu\u00f2 occasionalmente causare nausea e diarrea, soprattutto quando non viene assunta correttamente. Questi effetti collaterali sono rari, generalmente lievi e legati a fattori specifici relativi al dosaggio e alla modalit\u00e0 di assunzione:\r\n\r\n \tDosaggio eccessivo: \r\n\r\n \tAssumere quantit\u00e0 elevate di creatina (come durante una fase di \"carico\", ossia 20-25 g al giorno suddivisi in dosi) pu\u00f2 sovraccaricare l'apparato digerente.\r\n \tIl tratto gastrointestinale pu\u00f2 avere difficolt\u00e0 ad assorbire grandi quantit\u00e0 di creatina in una sola volta, causando nausea o diarrea osmotica, dovuta all'effetto della creatina nel richiamare e trattenere acqua nel tratto intestinale.\r\n\r\n\r\n \tScarsa solubilit\u00e0: La creatina monoidrato non \u00e8 molto solubile in acqua. Se viene consumata in forma poco disciolta, pu\u00f2 irritare il rivestimento dello stomaco o dell'intestino, provocando fastidi digestivi.\r\n \tAssunzione a stomaco vuoto: Consumare creatina senza cibo pu\u00f2 aumentare il rischio di nausea, soprattutto in individui sensibili.\r\n \tBassa qualit\u00e0 del prodotto: Creatina contaminata o di qualit\u00e0 scadente (con impurezze come la creatinina o il dicianodiamide) potrebbe pi\u00f9 facilmente causare disturbi gastrointestinali.\r\n \tCombinazioni con altri integratori: Se la creatina viene assunta insieme ad altri integratori, come quelli contenenti caffeina o zuccheri in grandi quantit\u00e0, il rischio di disagio gastrointestinale pu\u00f2 aumentare.\r\n\r\nCome ridurre il rischio di effetti collaterali\r\n\r\n \tDose corretta: Preferire la dose di mantenimento (3-5 g al giorno) rispetto a una fase di carico pi\u00f9 aggressiva.\r\n \tDividere la dose: Se si sceglie una fase di carico (20-25 g al giorno), suddividerla in dosi pi\u00f9 piccole (4-5 g) distribuite durante la giornata per facilitare l'assorbimento.\r\n \tDisciogliere bene la creatina: Assicurarsi che la creatina sia completamente dissolta in acqua o in un'altra bevanda prima del consumo.\r\n \tAssunzione con il pasto: Consumare la creatina durante o subito dopo i pasti per ridurre l'irritazione dello stomaco (possibilmente con presenza significativa di carboidrati, per favorire l'ingresso nella cellula muscolare).\r\n \tScegliere prodotti di alta qualit\u00e0: Preferire creatina monoidrato di grado farmaceutico o certificata da enti indipendenti (ad esempio Creapure).\r\n\r\n\r\nLa creatina fa male ai reni?\r\nSebbene alcuni report di casi clinici e studi su modelli animali suggeriscano che la creatina possa compromettere la funzionalit\u00e0 renale, i trial clinici controllati non hanno mai confermato questa ipotesi.\r\n\r\n\u00c8 importante sottolineare che l'integrazione di creatina pu\u00f2 prevedibilmente determinare un aumento dei livelli di creatinina (nel sangue e nelle urine) in alcuni soggetti, ma questo incremento non \u00e8 necessariamente indicativo di disfunzione renale, poich\u00e9 la creatinina rappresenta un sottoprodotto naturale della conversione spontanea della creatina nell'organismo.\r\n\r\nUn'importante meta-analisi condotta nel 2019 ad opera della National Kidney Foundation ha concluso che \"l'integrazione di creatina, nelle quantit\u00e0 e per i periodi analizzati, non provoca danni ai reni\".\r\n\r\nConclusioni simili si raggiungono anche per quanto riguarda un possibile effetto favorente la precipitazione di calcoli renali, mai dimostrato.\r\nRitenzione idrica\r\nLa creatina \u00e8 una sostanza osmoticamente attiva, questo significa che tende ad attrarre acqua; un aumento del contenuto di creatina nel corpo potrebbe quindi teoricamente comportare una maggiore ritenzione idrica.\r\n\r\n\u00c8 tuttavia importante sottolineare che l'eventuale (eventuale!) aumento di liquidi potrebbe verificarsi a livello intracellulare (nella cellula muscolare), non nel liquido che circonda le cellule.\r\n\r\nQuesto significa che l'effetto complessivo, qualora si verificasse, avrebbe ricadute principalmente positive, poich\u00e9 l'aumento di acqua intracellulare \u00e8 associato a un ambiente favorevole alla sintesi proteica e alla crescita muscolare, senza causare gonfiore (tipico ad esempio della ritenzione idrica da eccesso di sale) o disidratazione sistemica.\r\nFa ingrassare?\r\nUn aumento di peso \u00e8 un possibile effetto collaterale dell'integrazione di creatina, ma non \u00e8 dovuto a un accumulo di grasso. Le cause principali del potenziale aumento di peso includono:\r\n\r\n \tAumento della ritenzione idrica intracellulare: La creatina \u00e8 una sostanza osmoticamente attiva, quindi favorisce il richiamo di acqua all'interno delle cellule muscolari, contribuendo a un aumento temporaneo del peso corporeo. Questo non rappresenta un incremento di massa grassa ma \u00e8 un fenomeno che pu\u00f2 favorire la sintesi proteica e la crescita muscolare (vedi paragrafo precedente).\r\n \tIncremento della massa muscolare: Studi dimostrano che la creatina, in combinazione con un allenamento di resistenza, pu\u00f2 favorire l'aumento della massa magra (muscoli). Questo pu\u00f2 comportare un aumento del peso corporeo, ma \u00e8 un effetto positivo, legato all'aumento della muscolatura.\r\n\r\nQuindi pu\u00f2 succedere che la bilancia indichi un peso superiore, ma entrambe le possibili spiegazioni sono positive (e hanno ricadute altrettanto positive anche davanti allo specchio, in quando il corpo apparirebbe pi\u00f9 tonico, non pi\u00f9 grasso).\r\nFa cadere i capelli? Causa alopecia?\r\nLa relazione tra creatina e alopecia nasce principalmente da uno studio del 2009 condotto su giocatori di rugby maschi, in cui si osserv\u00f2 un aumento significativo dei livelli di diidrotestosterone (DHT) dopo un regime di integrazione con creatina. Poich\u00e9 il DHT \u00e8 associato alla miniaturizzazione dei follicoli piliferi e alla calvizie androgenetica in soggetti geneticamente predisposti, si diffuse l\u2019idea che la creatina potesse contribuire alla perdita di capelli, ma di fatto:\r\n\r\n \tL\u2019aumento del DHT osservato nello studio non \u00e8 mai stato confermato da altre ricerche, e il legame tra l'integrazione di creatina e livelli di DHT non \u00e8 stato ulteriormente dimostrato. Inoltre, i livelli di DHT osservati rimasero comunque entro i limiti clinicamente normali.\r\n \tMancanza di evidenze dirette: Non ci sono studi che mostrino una correlazione diretta tra l\u2019uso di creatina e l\u2019aumento della caduta dei capelli o la progressione dell\u2019alopecia androgenetica.\r\n\r\nNon ci sono quindi prove solide che la creatina causi alopecia o favorisca la caduta dei capelli in individui sani, tuttavia in soggetti geneticamente predisposti alla calvizie androgenetica un aumento del DHT (se fosse confermato) potrebbe teoricamente influire sul processo, anche se il rischio \u00e8 probabilmente trascurabile rispetto ad altri fattori genetici e ormonali.\r\nFavorisce l'insorgenza di crampi?\r\nL'idea che la creatina possa causare crampi muscolari deriva da preoccupazioni iniziali legate alla sua capacit\u00e0 di trattenere acqua all'interno delle cellule muscolari. Si ipotizzava che ci\u00f2 potesse alterare l'equilibrio idrico ed elettrolitico, aumentando il rischio di crampi muscolari. Tuttavia, questa teoria non \u00e8 supportata da dati clinici, anche se sono possibili ovviamente casi di ipersensibilit\u00e0 individuali.\r\n\r\n \r\n\r\nLeggi anche: La creatina fa bene al cervello?","image":[{"@type":"ImageObject","url":"https:\/\/healthy.thewom.it\/wp-content\/uploads\/2025\/01\/creatina.jpg","width":1500,"height":1000}]}</script> <script type="text/javascript">var inSpecial=false;</script>  <meta name="google-site-verification" content="V827H3VQ7l7XuXTLD8RNj4mNcLvcOXlO5vR3Ql8DEss" />  <script> function isConsentGiven(siteId, cookiePolicyId) { var cs = document.cookie.split(';'); for (var i = 0; i < cs.length; i++) { while (cs[i].charAt(0) == ' ') cs[i] = cs[i].substring(1); if (cs[i].indexOf('_iub_cs-s' + siteId) == 0 || cs[i].indexOf('_iub_cs-' + cookiePolicyId) == 0) return true; } return false; } </script>  </head> <body data-rsssl=1 class="post-template-default single single-post postid-456512 single-format-standard"> <ame-mh selector-wrapper=".sal-page" bg-mh="#2a3b58"></ame-mh> <div id="sal-page" class="site sal-page"> <header class="sal-header" id="sal-header"> <div class="sal-header-container"> <div class="sal-header-logo"> <div class="sal-header-logo"> <a href="https://healthy.thewom.it" title="The Wom Healthy - 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Ecco (TUTTI) i possibili effetti collaterali</h1> <div class="sal-heading-author-container"> <span class="sal-heading-author barlow" data-authorattribute="di"> <a href="https://healthy.thewom.it/autori/roberto-gindro/">Dr. Roberto Gindro</a> </span> </div> </div> </div> </header> <div class="sal-outer barlow sal-leaf-accessori sal-leaf-accessori-top sal-mBottom4x"> <div class="sal-leaf-accessori-lastmod barlow">Ultima modifica <time datetime="2025-01-31 08:19">31.01.2025</time></div> <div class="sal-leaf-accessori-sharebox"> <a target="_BLANK" href="mailto:?subject=La+creatina+fa+male%3F+Ecco+%28TUTTI%29+i+possibili+effetti+collaterali&body=Ti%20consiglio%20questo%20articolo:%20La+creatina+fa+male%3F+Ecco+%28TUTTI%29+i+possibili+effetti+collaterali%20-%20https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareMAIL"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareMAIL"></use> </svg> </span> </a> <a href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareFB"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareFB"></use> </svg> </span> </a> <a href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F&text=La+creatina+fa+male%3F+Ecco+%28TUTTI%29+i+possibili+effetti+collaterali" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareTW"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareTW"></use> </svg> </span> </a> <a href="whatsapp://send?text=Leggi+questo+articolo%3A+https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareWA"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareWA"></use> </svg> </span> </a> </div> </div> <div class="entry-content sal-inner sal-leaf-content "> <div class="sal-leaf-text sal-color0 barlow sal-mBottom6x"> <div class="sal-widget-section sal-mBottom5x"> <div class="sal-leaf-indice sal-leaf-indice-article"><ul class="sal-leaf-indice-items sal-leaf-indice-items-article" id="toc-content-navigation"><li class="sal-leaf-indice-item"><a title="Effetti collaterali dimostrati" href="#effetticollateralidimostrati">Effetti collaterali dimostrati</a></li><li class="sal-leaf-indice-item"><a title="Disturbi gastrointestinali (nausea, diarrea, …)" href="#disturbigastrointestinalinauseadiarrea">Disturbi gastrointestinali (nausea, diarrea, …)</a><ul><li><a title="Come ridurre il rischio di effetti collaterali" href="#comeridurreilrischiodieffetticollaterali">Come ridurre il rischio di effetti collaterali</a></li></ul></li><li class="sal-leaf-indice-item"><a title="La creatina fa male ai reni?" href="#lacreatinafamaleaireni">La creatina fa male ai reni?</a></li><li class="sal-leaf-indice-item"><a title="Ritenzione idrica" href="#ritenzioneidrica">Ritenzione idrica</a></li><li class="sal-leaf-indice-item"><a title="Fa ingrassare?" href="#faingrassare">Fa ingrassare?</a></li><li class="sal-leaf-indice-item"><a title="Fa cadere i capelli? Causa alopecia?" href="#facadereicapellicausaalopecia">Fa cadere i capelli? Causa alopecia?</a></li><li class="sal-leaf-indice-item"><a title="Favorisce l’insorgenza di crampi?" href="#favoriscelinsorgenzadicrampi">Favorisce l’insorgenza di crampi?</a></li></ul></div><div id="toc-hook"> <p>La <a href="https://healthy.thewom.it/integratori/creatina/">creatina</a> è diventata uno degli integratori alimentari più utilizzati, apprezzata sia da atleti che da persone con condizioni cliniche specifiche (con recenti studi che ne hanno indagato gli effetti positivi sul cervello).</p><div class="amePlaceholderBox sal-mBottom4x hidedesktop"><div id="adv-gpt-box-mobile-container1"></div></div><div id="nativetop" class="nativeadv"></div> <p>Ma è davvero sicura? Nessun integratore è mai completamente scevro da rischi (nemmeno la creatina), ma l’attuale letteratura scientifica ne supporta un elevato grado di sicurezza quando assunta alle dosi raccomandate.</p> <p>Analizziamo in modo critico l’attuale letteratura, ricordando però che in caso di dubbi (soprattutto nel caso di patologie preesistenti) è indispensabile il parere del proprio medico.</p> <div id="attachment_456515" style="width: 1510px" class="wp-caption alignnone"><img fetchpriority="high" decoding="async" aria-describedby="caption-attachment-456515" class="wp-image-456515 size-full" src="https://healthy.thewom.it/wp-content/uploads/2025/01/creatina.jpg" alt="Misurino colmo di creatina" width="1500" height="1000" srcset="https://healthy.thewom.it/wp-content/uploads/2025/01/creatina-300x200.jpg 300w, https://healthy.thewom.it/wp-content/uploads/2025/01/creatina-1024x683.jpg 1024w, https://healthy.thewom.it/wp-content/uploads/2025/01/creatina-768x512.jpg 768w, https://healthy.thewom.it/wp-content/uploads/2025/01/creatina.jpg 1500w" sizes="(max-width: 1500px) 100vw, 1500px"><p id="caption-attachment-456515" class="wp-caption-text">Shutterstock/xm4thx</p></div> <h2 id="effetticollateralidimostrati">Effetti collaterali dimostrati</h2> <p>Tra gli effetti collaterali più comuni si annoverano:</p> <ul> <li><strong>Ritenzione idrica</strong>: è l’effetto più frequente, poiché la creatina attira l’acqua nei muscoli. Questo può causare un aumento temporaneo del peso corporeo (ma questo NON è un male, anzi!, vedi sotto nel paragrafo dedicato).</li> <li><strong>Disturbi gastrointestinali</strong>: alcuni individui possono sperimentare <a href="https://healthy.thewom.it/sintomi/crampi-stomaco/">crampi allo stomaco</a>, <a href="https://healthy.thewom.it/sintomi/nausea-vomito/">nausea</a> o <a href="https://healthy.thewom.it/sintomi/diarrea/">diarrea</a>, specialmente nelle fasi iniziali dell’integrazione.</li> </ul> <p>Più raramente sono invece stati segnalati</p><div id="adv-video-article"></div> <ul> <li><a href="https://healthy.thewom.it/sintomi/crampi-notturni/">Crampi muscolari</a>: sono stati aneddoticamente riportati da alcuni soggetti. Vedere sotto per una trattazione più completa.</li> </ul> <h2 id="disturbigastrointestinalinauseadiarrea">Disturbi gastrointestinali (nausea, diarrea, …)</h2> <p>La creatina può occasionalmente causare <strong>nausea</strong> e <strong>diarrea</strong>, soprattutto quando non viene assunta correttamente. Questi effetti collaterali sono rari, generalmente lievi e legati a fattori specifici relativi al dosaggio e alla modalità di assunzione:</p> <ol> <li><strong>Dosaggio eccessivo: </strong> <ul> <li><span style="font-size: 1rem;">Assumere quantità elevate di creatina (come durante una fase di “carico”, ossia 20-25 g al giorno suddivisi in dosi) può sovraccaricare l’apparato digerente.</span></li> <li>Il tratto gastrointestinale può avere difficoltà ad assorbire grandi quantità di creatina in una sola volta, causando <strong>nausea</strong> o <strong>diarrea osmotica</strong>, dovuta all’effetto della creatina nel richiamare e trattenere acqua nel tratto intestinale.</li> </ul> </li> <li><strong>Scarsa solubilità: </strong><span style="font-size: 1rem;">La creatina monoidrato non è molto solubile in acqua. Se viene consumata in forma poco disciolta, può irritare il rivestimento dello stomaco o dell’intestino, provocando fastidi digestivi.</span></li> <li><strong>Assunzione a stomaco vuoto: </strong><span style="font-size: 1rem;">Consumare creatina senza cibo può aumentare il rischio di </span><strong style="font-size: 1rem;">nausea</strong><span style="font-size: 1rem;">, soprattutto in individui sensibili.</span></li> <li><strong>Bassa qualità del prodotto: </strong><span style="font-size: 1rem;">Creatina contaminata o di qualità scadente (con impurezze come la creatinina o il dicianodiamide) potrebbe più facilmente causare disturbi gastrointestinali.</span></li> <li><strong>Combinazioni con altri integratori: </strong><span style="font-size: 1rem;">Se la creatina viene assunta insieme ad altri integratori, come quelli contenenti <a href="https://healthy.thewom.it/integratori/caffeina/">caffeina</a> o zuccheri in grandi quantità, il rischio di disagio gastrointestinale può aumentare.</span></li> </ol> <h3 id="comeridurreilrischiodieffetticollaterali"><strong>Come ridurre il rischio di effetti collaterali</strong></h3> <ol> <li><strong>Dose corretta: </strong><span style="font-size: 1rem;">Preferire la dose di mantenimento (3-5 g al giorno) rispetto a una fase di carico più aggressiva.</span></li> <li><strong>Dividere la dose: </strong><span style="font-size: 1rem;">Se si sceglie una fase di carico (20-25 g al giorno), suddividerla in dosi più piccole (4-5 g) distribuite durante la giornata per facilitare l’assorbimento.</span></li> <li><strong>Disciogliere bene la creatina: </strong><span style="font-size: 1rem;">Assicurarsi che la creatina sia completamente dissolta in acqua o in un’altra bevanda prima del consumo.</span></li> <li><strong>Assunzione con il pasto: </strong><span style="font-size: 1rem;">Consumare la creatina durante o subito dopo i pasti per ridurre l’irritazione dello stomaco (possibilmente con presenza significativa di <a href="https://healthy.thewom.it/alimentazione/carboidrati/">carboidrati</a>, per favorire l’ingresso nella cellula muscolare).</span></li> <li><strong>Scegliere prodotti di alta qualità: </strong><span style="font-size: 1rem;">Preferire creatina monoidrato di grado farmaceutico o certificata da enti indipendenti (ad esempio Creapure).</span></li> </ol> <ul class="modInfoCommerce modInfoCommerce-full"> <li class="modInfoCommerce__item "> <a href="https://www.amazon.it/dp/B0C2HFZKWJ?tag=pluginhealthy-21&linkCode=osi&th=1&psc=1&ascsubtag=456512-widget-desktop-womhealthy-B0C2HFZKWJ" class="modInfoCommerce__picture store-link" target="_blank" rel="nofollow" title="WFN Approved Creatine - 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Polvere - Vegano – 83 porzioni - Prodotto in Germania - Testato in laboratorio esterno" data-vars-name="WFN Approved Creatine - Creapure - Neutro - 250 g - Creatina monoidrato - Polvere - Vegano – 83 porzioni - Prodotto in Germania - Testato in laboratorio esterno" data-vars-brand="FITNESS & HEALTH GmbH" data-vars-merchant="Amazon" data-vars-linktype="txt"> WFN Approved Creatine - Creapure - Neutro - 250 g - Creatina monoidrato - Polvere - Vegano – 83 porzioni - Prodotto in Germania - Testato in laboratorio esterno </a> </div> <div class="modInfoCommerce__info"> <div class="modInfoCommerce__text__subTitle" data-company="Amazon"> <span class="modInfoCommerce__text__subTitle__company"> <img decoding="async" src="https://healthy.thewom.it/wp-content/plugins/store_affiliation/images/amazon.png" title="da Amazon" alt="da Amazon"> </span> </div> <div class="modInfoCommerce__info__price"> € 23,90 </div> </div> <div class="modInfoCommerce__action"> <a role="button" href="https://www.amazon.it/dp/B0C2HFZKWJ?tag=pluginhealthy-21&linkCode=osi&th=1&psc=1&ascsubtag=456512-widget-desktop-womhealthy-B0C2HFZKWJ" class="modInfoCommerce__button store-link" target="_blank" rel="nofollow" title="WFN Approved Creatine - Creapure - Neutro - 250 g - Creatina monoidrato - Polvere - Vegano – 83 porzioni - Prodotto in Germania - Testato in laboratorio esterno" data-vars-name="WFN Approved Creatine - Creapure - Neutro - 250 g - Creatina monoidrato - Polvere - Vegano – 83 porzioni - Prodotto in Germania - Testato in laboratorio esterno" data-vars-brand="FITNESS & HEALTH GmbH" data-vars-merchant="Amazon" data-vars-linktype="btn"> Vedi l'offerta </a> </div> </li> </ul> <script> (function () { function isMobile() { try { document.createEvent("TouchEvent"); return screen.width < 1440; } catch (e) { return false; } } var is_mobile = isMobile(); var links = document.getElementsByClassName("store-link"); for (var i = 0; i < links.length; i++) { var link = links.item(i); var item_href = link.getAttribute('href'); if (is_mobile) { link.setAttribute('href', item_href.replace(/(ascsubtag=[^&=]*-)(desktop)/, '$1mobile')); } else { link.setAttribute('href', item_href.replace(/(ascsubtag=[^&=]*-)(mobile)/, '$1desktop')); } } })(); </script> <h2 id="lacreatinafamaleaireni">La creatina fa male ai reni?</h2> <p>Sebbene alcuni report di casi clinici e studi su modelli animali suggeriscano che la creatina possa compromettere la funzionalità renale, i trial clinici controllati <span style="text-decoration: underline;">non</span> hanno mai confermato questa ipotesi.</p> <p>È importante sottolineare che l’integrazione di creatina può prevedibilmente determinare un aumento dei livelli di <a href="https://healthy.thewom.it/esami-e-analisi/creatinina/">creatinina</a> (nel sangue e nelle urine) in alcuni soggetti, ma questo incremento <a href="https://pubmed.ncbi.nlm.nih.gov/36986197/">non è necessariamente indicativo di disfunzione renale</a>, poiché la creatinina rappresenta un sottoprodotto naturale della conversione spontanea della creatina nell’organismo.</p> <p>Un’importante <a href="https://www.jrnjournal.org/article/S1051-2276(19)30228-6/abstract">meta-analisi</a> condotta nel 2019 ad opera della National Kidney Foundation ha concluso che “<strong>l’integrazione di creatina, nelle quantità e per i periodi analizzati, non provoca danni ai reni</strong>“.</p> <p>Conclusioni simili si raggiungono anche per quanto riguarda un possibile effetto favorente la precipitazione di <a href="https://healthy.thewom.it/salute/calcoli-coliche-renali/">calcoli renali</a>, <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9585689/">mai dimostrato</a>.</p> <h2 id="ritenzioneidrica">Ritenzione idrica</h2> <p>La creatina è una sostanza osmoticamente attiva, questo significa che tende ad <em>attrarre</em> acqua; un aumento del contenuto di creatina nel corpo potrebbe quindi teoricamente comportare una maggiore <a href="https://healthy.thewom.it/sintomi/ritenzione-idrica/">ritenzione idrica</a>.</p><div id="relatedSearchesLeaf" class="sal-mBottom2x"></div> <p>È tuttavia importante sottolineare che l’eventuale (eventuale!) aumento di liquidi potrebbe verificarsi a livello intracellulare (nella cellula muscolare), non nel liquido che circonda le cellule.</p> <p>Questo significa che l’effetto complessivo, <span style="text-decoration: underline;">qualora si verificasse</span>, avrebbe ricadute principalmente positive, poiché l’aumento di acqua intracellulare è associato a un ambiente favorevole alla sintesi proteica e alla crescita muscolare, senza causare gonfiore (tipico ad esempio della ritenzione idrica da eccesso di sale) o <a href="https://healthy.thewom.it/sintomi/disidratazione/">disidratazione</a> sistemica.</p> <h2 id="faingrassare">Fa ingrassare?</h2> <p>Un aumento di peso è un possibile effetto collaterale dell’integrazione di creatina, ma <strong>non è dovuto a un accumulo di grasso</strong>. Le cause principali del potenziale aumento di peso includono:</p> <ul> <li><strong>Aumento della ritenzione idrica intracellulare</strong>: La creatina è una sostanza osmoticamente attiva, quindi favorisce il richiamo di acqua all’interno delle cellule muscolari, contribuendo a un aumento temporaneo del peso corporeo. Questo non rappresenta un incremento di massa grassa ma è un fenomeno che può favorire la sintesi proteica e la crescita muscolare (vedi paragrafo precedente).</li> <li><strong>Incremento della massa muscolare</strong>: Studi dimostrano che la creatina, <span style="text-decoration: underline;">in combinazione con un allenamento di resistenza</span>, può favorire l’aumento della massa magra (muscoli). Questo può comportare un aumento del peso corporeo, ma è un effetto positivo, legato all’aumento della muscolatura.</li> </ul> <p>Quindi può succedere che la bilancia indichi un peso superiore, ma entrambe le possibili spiegazioni sono positive (e hanno ricadute altrettanto positive anche davanti allo specchio, in quando il corpo apparirebbe più tonico, non più grasso).</p> <h2 id="facadereicapellicausaalopecia">Fa cadere i capelli? Causa alopecia?</h2> <p>La relazione tra creatina e <a href="https://healthy.thewom.it/salute/alopecia/">alopecia</a> nasce principalmente da uno <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19741313">studio</a> del 2009 condotto su giocatori di rugby maschi, in cui si osservò un aumento significativo dei livelli di diidrotestosterone (DHT) dopo un regime di integrazione con creatina. Poiché il DHT è associato alla miniaturizzazione dei follicoli piliferi e alla calvizie androgenetica in soggetti geneticamente predisposti, si diffuse l’idea che la creatina potesse contribuire alla perdita di capelli, ma di fatto:</p> <ul> <li>L’aumento del DHT osservato nello studio non è mai stato confermato da altre ricerche, e il legame tra l’integrazione di creatina e livelli di DHT non è stato ulteriormente dimostrato. Inoltre, i livelli di DHT osservati rimasero comunque entro i limiti clinicamente normali.</li> <li>Mancanza di evidenze dirette: Non ci sono studi che mostrino una correlazione diretta tra l’uso di creatina e l’aumento della caduta dei capelli o la progressione dell’alopecia androgenetica.</li> </ul> <p>Non ci sono quindi prove solide che la creatina causi alopecia o favorisca la caduta dei capelli in individui sani, tuttavia in soggetti geneticamente predisposti alla calvizie androgenetica un aumento del DHT (se fosse confermato) potrebbe teoricamente influire sul processo, anche se <a href="https://healthy.thewom.it/integratori/creatina-caduta-capelli/">il rischio è probabilmente trascurabile</a> rispetto ad altri fattori genetici e ormonali.</p> <h2 id="favoriscelinsorgenzadicrampi">Favorisce l’insorgenza di crampi?</h2> <p>L’idea che la creatina possa causare crampi muscolari deriva da preoccupazioni iniziali legate alla sua capacità di trattenere acqua all’interno delle cellule muscolari. Si ipotizzava che ciò potesse alterare l’equilibrio idrico ed elettrolitico, aumentando il rischio di crampi muscolari. Tuttavia, questa teoria non è supportata da dati clinici, anche se sono possibili ovviamente casi di ipersensibilità individuali.</p> <p> </p> <p>Leggi anche: <a href="https://healthy.thewom.it/integratori/creatina-cervello/">La creatina fa bene al cervello?</a></p> </div> </div> </div> <div class="entry-footer">  <ins class="adsbygoogle fluid" style="display:block; text-align:center;" data-ad-layout="in-article" data-ad-format="fluid" data-ad-client="ca-pub-0820544532937748" data-ad-slot="9043543599"></ins> <div class="clearfix"></div> <div class="sal-leaf-accessori sal-leaf-accessori-bottom sal-mBottom4x"> <div class="sal-leaf-accessori-sharebox"> <a target="_BLANK" href="mailto:?subject=La+creatina+fa+male%3F+Ecco+%28TUTTI%29+i+possibili+effetti+collaterali&body=Ti%20consiglio%20questo%20articolo:%20La+creatina+fa+male%3F+Ecco+%28TUTTI%29+i+possibili+effetti+collaterali%20-%20https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareMAIL"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareMAIL"></use> </svg> </span> </a> <a href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareFB"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareFB"></use> </svg> </span> </a> <a href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F&text=La+creatina+fa+male%3F+Ecco+%28TUTTI%29+i+possibili+effetti+collaterali" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareTW"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareTW"></use> </svg> </span> </a> <a href="whatsapp://send?text=Leggi+questo+articolo%3A+https%3A%2F%2Fhealthy.thewom.it%2Fintegratori%2Fcreatina-effetti-collaterali%2F" class="sal-leaf-accessori-shareitem sal-leaf-accessori-shareWA"> <span class="sal-icon"> <svg viewBox="0 0 28 28"> <use xlink:href="https://healthy.thewom.it/wp-content/themes/farmacoecura/css/images/min/icons.svg#foglia-shareWA"></use> </svg> </span> </a> </div> </div> <section class="sal-author-block sal-mBottom4x barlow"> <h3 class="sal-list-separator sal-list-heading barlow-cond sal-mBottom3x"><span>Autore</span></h3> <div class="sal-author-container sal-author-container sal-mBottom4x"> <div class="sal-author-item"> <div class="sal-author-data barlow-cond"> <h3 class="sal-author-name"><a href="https://healthy.thewom.it/autori/roberto-gindro/">Dr. Roberto Gindro</a></h3> <small class="sal-author-jobtitle">Divulgatore</small> </div> </div> <span class="sal-author-bio"><p>Laurea in Farmacia con lode, PhD in Scienza delle sostanze bioattive.</p> <p>Fondatore del sito, si occupa ad oggi della supervisione editoriale e scientifica.</p> </span> </div> </section> </div> <div class="clearfix"></div> </div>  <div class="entry-navigation"> <section class="sal-list sal-mBottom4x barlow"> <div class="sal-list-separator sal-list-heading barlow-cond sal-mBottom3x"><span>Articoli Correlati</span></div> <a id="0"></a> <div class=""> <ul> <li> <div class="sal-list-item sal-mBottom5x"> <a href="https://healthy.thewom.it/integratori/creatina/" class="sal-list-item-pictorial"> <picture> <source srcset="https://healthy.thewom.it/wp-content/uploads/2023/06/creatina-cover.jpg"> <img src="/wp-content/themes/farmacoecura/css/images/sal-img-placeholder.svg" alt="Creatina: cos'è, a cosa serve, come si assume e altre domande" class="" loading="lazy"> </picture> </a> <div class="sal-list-item-text barlow-cond"> <a class="sal-list-item-title" href="https://healthy.thewom.it/integratori/creatina/" title="Creatina: cos'è, a cosa serve, come si assume e altre domande">Creatina: cos'è, a cosa serve, come si assume e altre domande</a> <p class="sal-list-item-summary sal-line-clamp sal-mBottom1x barlow"><a href="https://healthy.thewom.it/integratori/creatina/" title="Creatina: cos'è, a cosa serve, come si assume e altre domande">Cos'è la creatina? 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Su safari mobile entra in questo caso subito, quindi lo escludo window.history.back(); } else { const trackEvent = false; // accende / spegne gli eventi GA console.log("trackBack init - eventi tracciati:", (trackEvent? 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Questo evita l'apertura della modal su safari in caso di back da un articolo window.removeEventListener("popstate", popstateEventAction); window.history.back(); return; } postTcfReady(()=>{ showModalBack(); document.querySelector(".modal-back-btn").addEventListener("click", () => { if(trackEvent) { gtag("event", "Modale Back", { "event_action": "x" }); } closeModalBack(); }); }); postConsentRejected(()=>{ if(trackEvent) { gtag("event", "Modale Back", { "event_action": "view NO consent", "non_interaction": true }); } window.history.back(); }); } const initModalBack = () => { document.body.removeEventListener("click", initModalBack); window.history.pushState("modalForward", null, ""); historyLenghtRef = window.history.length; postTcfReady(()=>{ if(!document.location.href.includes("/ricerca?")){ pageOptions.relatedSearchTargeting = "content"; _googCsa('relatedsearch', pageOptions, rsblock1); if(trackEvent) { gtag("event", "Modale Back", { "event_action": "call ads", "non_interaction": true }); } } }); window.addEventListener("popstate", popstateEventAction); console.log("trackBack pushState"); } document.body.addEventListener("click", initModalBack); } } })(); //startPushNoConsent (function(){ //Le variabili website e targetElementId sono inizializzate a template e sono comuni per initPush e PushNoConsent /*let iframeVideo = document.querySelector('.tw-container-video'); if(iframeVideo != null) { console.log('[pushNoConsent] bloccata per presenza video in pagina'); return false; }*/ let trackAnalytics = false; function startPushNoConsent() { window.initStartPushNoConsent = 1; console.log('[pushNoConsent] track init'); if (typeof gtag === "function" && trackAnalytics == true) { gtag("event", 'pushNoConsentV1', { event_action: 'init', event_label: document.location.href, non_interaction: true }); } window.GlobalPusTimerStart = new Date().getTime(); let pushConfObj = { website, type: "flyfirst", flyMode: "fade", closeFlyingAfter: 7000, adServer: 'freewheel', targetElementId, eventListener: (eventName, eventData) => { const eventBlocking = [ "adblocker_detected", "preroll_not_served", "autoplay_denied", "triggered_fallback", "preroll_error" ]; if(eventName === 'preroll_started'){ console.log('[pushNoConsent]', 'track preroll started'); if (typeof gtag === "function" && trackAnalytics == true) { gtag("event", 'pushNoConsentV1', { event_action: 'preroll_started', event_label: document.location.href, non_interaction: true }); } } // [ NPA ] event listeners per interstital ADK (adv fill se non c'è preroll) // if (eventBlocking.includes(eventName)) { // if (typeof AdKaora.loadInterstitial === 'function' && !adkPageSlots.displayed.adk_interstitial) { // console.debug('[ NPA ] init interstitial ADK causa preroll non erogato'); // AdKaora.loadInterstitial("adk_death-div"); // } // } } }; (function (a, l, t, e, r) { a[e] = a[e] || function (s) { (a[e].run = a[e].run || []).push(s) }; let g, z = l.getElementsByTagName(t)[0]; if (l.getElementById(e)) { return; } g = l.createElement(t); g.id = e; g.src = r; g.async = 1; z.parentNode.insertBefore(g, z); }(window, document, 'script', 'AVPushLoader', "https://ptp.stbm.it/pushdown/loader/av/pushdown-loader.js")); console.log('[pushNoConsent]', pushConfObj); AVPushLoader(pushConfObj); } // let startInterstitialNoConsent = () => { // // [ NPA ] event listeners per interstital ADK (adv fill se non c'è preroll) // const eventBlocking = [ // "adblocker_detected", // "preroll_not_served", // "autoplay_denied", // "triggered_fallback", // "preroll_error" // ]; // eventBlocking.forEach(function(e) { // window.addEventListener(e, function() { // if (typeof AdKaora.loadInterstitial === 'function' && !adkPageSlots.displayed.adk_interstitial) { // console.debug('[ NPA ] init interstitial ADK causa preroll non erogato'); // AdKaora.loadInterstitial("adk_death-div"); // } // }); // }) // } const ADVNoConsentFlow = () => { // let NPAtarget = window.innerWidth < 1000 ? 'adv-gpt-box-mobile-container1' : 'adv-gpt-box-container1'; // let NPAtargetBox = document.getElementById(NPAtarget); // if(NPAtargetBox != 'undefined' && NPAtargetBox != null) { // NPAtargetBox.parentNode.parentNode.setAttribute('id','box300NPA'); // } setTimeout(function() { mmLoader({ src: "https://cdn.adkaora.space/mondadori/generic/prod/adk-init.js", async: true, type: 'module' }, "ADVNoConsentFlow") // .then(element => { // document.addEventListener("PWTBidComplete", function(e) { // console.debug('PWTBid completed.') // // check slot vuoti: // let emptyNPASlots = {}; // if(ifrmAdvMh.offsetHeight === 0){ // Object.assign(emptyNPASlots, { 'masthead': divslotnameStrip }); // } else { // AmeMh.strip_animation(); // } // if(ifrmAdvBox.offsetHeight === 0){ // Object.assign(emptyNPASlots, { 'box300': divslotnameBox }); // } // document.dispatchEvent(new CustomEvent("EmptyNPASlot", { // detail: emptyNPASlots // })); // }); // }, "ADVNoConsentFlow") // .then( element => mmLoader({ // src: "https://adv.mediamond.it/librerie/js-no-consent/ame/adv_no_consent.js", // async: true // }, "ADVNoConsentFlow")) .then(element => { startPushNoConsent(); // startInterstitialNoConsent(); }, "ADVNoConsentFlow"); },500); } postConsentRejected(ADVNoConsentFlow); // debug only: // document.addEventListener("EmptyNPASlot", function(e) { // console.debug('[NPA] EmptyNPASlot event:', e.detail); // }); })(); function startAdsense() { setTimeout(() => { mmLoader({ "data-ad-client": "ca-pub-7835681492882497", src: "https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js", async: true }, "AdsenseChain").then( element => { let blankAdSlots = document.querySelectorAll(".adsbygoogle:not([data-adsbygoogle-status='done'])"); if(blankAdSlots.length > 0){ for (var i = 0; i < blankAdSlots.length; i++) { (adsbygoogle = window.adsbygoogle || []).push({}); } } } ); }, 2000); } postTcfReady(startAdsense); /*postTcfReady*/ async function postTcfReady(cb) { if(typeof tcfIsReady !== 'undefined') { console.log('[Ame consent] cb by variable:',cb.name); await yieldToMain(); cb(); } else { window.addEventListener('tcf2Ready', async function() { console.log('[Ame consent] cb by listener:',cb.name); await yieldToMain(); cb(); }) } } /*postTcfRejected*/ async function postConsentRejected(cb) { if (typeof window.ameConsentGiven !== 'undefined' && window.ameConsentGiven === false) { console.log('[Ame consent rejected] cb by variable:', cb.name); await yieldToMain(); cb(); } else { window.addEventListener('consentRejected', async function () { console.log('[Ame consent rejected] cb by listener:', cb.name); await yieldToMain(); cb(); }); } } /*MM LOADER*/ function mmLoader(objAttr, chainId = null, elementType = "script", target = document.body) { return new Promise(async function (resolve, reject) { let element = document.createElement(elementType); for (const property in objAttr) { element.setAttribute(property, objAttr[property]); } let path = objAttr.src || objAttr.href; element.onload = async () => { await yieldToMain(); resolve(element); console.log(`[mmLoader] ${path} caricato!`, "chainId_" + chainId + " Time: " + performance.now()); }; element.onerror = e => { reject( new Error(`[mmLoader] Errore sul caricamento di ${path}`) ); console.log(e); }; await yieldToMain(); target.appendChild(element); }); } function wait(ms) { return new Promise(resolve => setTimeout(resolve, ms)); } function loadJsbyIO (src, targetSelector, rootMargin) { let options = { root: null, rootMargin: rootMargin || "0px", threshold: 1.0, }; const callback = (entries, observer) => { entries.forEach((entry) => { if (entry.isIntersecting) { console.log(`[loadJsbyIO] loading ${src} by intersection of ${targetSelector}`); mmLoader({ src: src, async: true }); obs.disconnect(); } }); }; let obs = new IntersectionObserver(callback, options); let target = document.querySelector(targetSelector); obs.observe(target); }; async function yieldToMain () { if ('scheduler' in window && 'yield' in scheduler) { return scheduler.yield(); } return new Promise(resolve => { setTimeout(resolve, 0); }); } /*END MM LOADER*/ </script> <script type='text/javascript'> window.addEventListener('load', function() { console.log("subtag check"); var ABtest_subtab_part='noads'; if (typeof ABtest_showads !== 'undefined') { if (ABtest_showads) { ABtest_subtab_part='showads'; } } else { ABtest_subtab_part='showads'; } console.log("ABtest_subtab_part: "+ABtest_subtab_part); var subtag_ads=ABtest_subtab_part; var arr = [], collegamenti = document.links; var count_progressivo_prodotto=0; var old_amazon_link=''; var posizione_prodotto='P0'; for(var i=0; i<collegamenti.length; i++) { var text=collegamenti[i].href; if((text.startsWith('https://www.amazon.it')) && (text.includes('tag='))){ var url = text; if(url != old_amazon_link) { count_progressivo_prodotto++; posizione_prodotto='P' + count_progressivo_prodotto old_amazon_link=url; } var linktype = collegamenti[i].getAttribute('data-vars-linktype'); if(linktype) { posizione_prodotto='P' + count_progressivo_prodotto +'T' + linktype; } else{ var linkclass = collegamenti[i].getAttribute('class'); if(linkclass=='btn-offerte-amazon'){ linktype='btn' posizione_prodotto='P' + count_progressivo_prodotto +'T' + linktype; } else { posizione_prodotto = 'P' + count_progressivo_prodotto + 'Tnd'; } } var expression ='(?:[/dp/]|$)([A-Z0-9]{10})'; var regex = new RegExp(expression); var id_prodotto_amazon='nd'; m = url.match(regex); if (m) { id_prodotto_amazon=m[1] } var stringa_subtag_corretta= '456512-widget-desktop-womhealthy' + '-' + id_prodotto_amazon + '-' + posizione_prodotto + '-' + subtag_ads; console.log("Subtag corretta: " + stringa_subtag_corretta); var posizione_get = text.indexOf("?"); if(posizione_get > -1){ var valori_get = text.slice((posizione_get + 1)); if(valori_get.includes('tag=')){ if(valori_get.includes('ascsubtag=')){ var parametri=valori_get.split("&"); var parametri_nosubtag=[]; parametri.forEach(function(chiave_valore){ var splitta_chiave_valore=chiave_valore.split("="); if(splitta_chiave_valore[0]=='ascsubtag'){ var stringa_subtag=splitta_chiave_valore[1]; collegamenti[i].href=text.replace(stringa_subtag, stringa_subtag_corretta); } else{ parametri_nosubtag.push(chiave_valore) } }); parametri_nosubtag.push('ascsubtag=' + stringa_subtag_corretta) var valori_get_nosubtag=parametri_nosubtag.join("&") collegamenti[i].href=text.replace(valori_get, valori_get_nosubtag); 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