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<div class="breadcrumbs alignfull"><div class="breadcrumbs__inner"><div class="breadcrumbs__wrapper"><div class="breadcrumbs"><span><span><a href="https://www.ppd.com/our-solutions/">Our Solutions</a></span> <span class="breadcrumb-separator"></span> <span><a href="https://www.ppd.com/our-solutions/ppd-laboratories/">PPD Laboratory Services</a></span> <span class="breadcrumb-separator"></span> <span><a href="https://www.ppd.com/our-solutions/ppd-laboratories/gmp-lab/">GMP Lab</a></span> <span class="breadcrumb-separator"></span> <span class="breadcrumb_last" aria-current="page">GMP Lab Capabilities</span></span></div></div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_a832b9-3f" class="em-row-layout-inner em-margin-top--default em-margin-bottom--none em-tablet-margin-top--default em-tablet-margin-bottom--none em-mobile-margin-top--default em-mobile-margin-bottom--none em-layout-id_a832b9-3f"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-left-golden em-tab-layout-left-golden em-m-colapse-right-to-left em-mobile-layout-row em-padding-top--default em-padding-bottom--none em-tablet-padding-top--default em-tablet-padding-bottom--none em-mobile-padding-top--default em-mobile-padding-bottom--small alignwide"> <div class="wp-block-emagine-column emagine-column8647 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--large em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--medium em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--large em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading mb-0" id="biosafety-capabilities-expertise">Biosafety capabilities and expertise</h2> <h3 class="wp-block-heading">Advanced mycoplasma and viral testing services to support development of biologics and cell and gene therapies.</h3> <p>We have expanded testing capabilities offering compendial and novel validated biosafety methods. With extensive expertise in good laboratory practice (GLP) and good manufacturing practice (GMP) regulations and polymerase chain reaction (PCR) technologies, our biosafety lab offers fast, simple, and reliable options for characterization of cell banks, and for unprocessed bulk and final products.</p> </div></div> <div class="wp-block-emagine-column emagine-column9216 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><section id="anchor-link-menu-block_5a2038ca124631633632267a17975358" class="anchor-link-menu alignfull"> <div class="anchor-link-menu__title"> On this page </div> <div class="anchor-link-menu__links"> <ul> <li><a href="#biosafety-capabilities-expertise">Biosafety Capabilities and Expertise</a></li> <li><a href="#cba">Cell-Based Assays</a></li> <li><a href="#EandL">Extractables and Leachables</a></li> <li><a href="#msse">Mass Spectrometry and Structural Elucidation </a></li> <li><a href="#micro">Microbiology</a></li> <li><a href="#pmc">Physicochemical Material Characterization</a></li> <li><a href="#raw-materials-testing">Raw Materials Testing</a></li> <li><a href="#stability">Stability</a></li> <li><a href="#reference-standard-and-specialty-services">Reference Standard and Specialty Services</a></li> </ul> </div> </section> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_ea8955-0a" class="em-row-layout-inner em-margin-top--small em-margin-bottom--default em-tablet-margin-top--small em-tablet-margin-bottom--default em-mobile-margin-top--none em-mobile-margin-bottom--default em-layout-id_ea8955-0a"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--default em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column2785 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--large em-mobile-padding-left--none"> <h4 class="wp-block-heading mb-0" style="font-size:1.31rem;font-style:normal;font-weight:500">USP/EP/JP/PTC compliant mycoplasma assays</h4> <ul class="mb-0 wp-block-list"> <li>Culture method</li> <li>Indicator cell culture method</li> <li>Mycoplasmastasis assay</li> <li>MycoSEQ Plus real-time PCR assay</li> <li>Enrichment MycoSEQ Plus real-time PCR assay</li> </ul> <div class="wp-block-emagine-button"><a class="wp-block-emagine-button__more has-purple-background-color block-btn block-btn--sm block-btn--simple" style="color:#6d44a1" href="#micro" rel=""><span class="block-btn__hover" style="color:#4f2683;background-color:transparent">Learn more about our microbiology testing capabilities<svg width="32" height="32" viewBox="0 0 1792 1792" xmlns="http://www.w3.org/2000/svg"><path fill="currentColor" d="M1171 960q0 13-10 23l-466 466q-10 10-23 10t-23-10l-50-50q-10-10-10-23t10-23l393-393-393-393q-10-10-10-23t10-23l50-50q10-10 23-10t23 10l466 466q10 10 10 23z"></path></svg></span></a></div> <h4 class="wp-block-heading mb-0" style="font-size:1.31rem;font-style:normal;font-weight:500">Viral safety testing</h4> <ul class="mb-0 wp-block-list"> <li>In vitro adventitious viruses assays </li> <li>ViralSEQ real-time PCR assay for minute virus of mice</li> <li>Replication-competent assay for adeno-associated virus </li> <li>Replication-competent assay for lentiviruses </li> </ul> <div class="wp-block-emagine-button"><a class="wp-block-emagine-button__more has-purple-background-color block-btn block-btn--sm block-btn--simple" style="color:#6d44a1" href="#cba" rel=""><span class="block-btn__hover" style="color:#4f2683;background-color:transparent">Learn more about our cell-based assay capabilities<svg width="32" height="32" viewBox="0 0 1792 1792" xmlns="http://www.w3.org/2000/svg"><path fill="currentColor" d="M1171 960q0 13-10 23l-466 466q-10 10-23 10t-23-10l-50-50q-10-10-10-23t10-23l393-393-393-393q-10-10-10-23t10-23l50-50q10-10 23-10t23 10l466 466q10 10 10 23z"></path></svg></span></a></div> <h4 class="wp-block-heading mb-0" style="font-size:1.31rem;font-style:normal;font-weight:500">Product type experience</h4> <ul class="wp-block-list"> <li>Analytical/master/working cell banks</li> <li>Cell and gene therapy </li> <li>Monoclonal antibodies </li> <li>Media</li> </ul> </div></div> <div class="wp-block-emagine-column emagine-column7458 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h4 class="wp-block-heading mb-0" style="font-size:1.31rem;font-style:normal;font-weight:500">Well-designed environmental control systems</h4> <ul class="wp-block-list"> <li>2,000 sq ft of HEPA filtered, restricted access lab space with dedicated areas for:  <ul class="wp-block-list"> <li>Mycoplasma testing  </li> <li>Viral testing  </li> <li>Pre- / Post-amplification PCR  </li> </ul> </li> <li>REES Scientific automated temperature monitoring system</li> </ul> <h3 class="wp-block-heading">Key instrumentation:</h3> <ul class="wp-block-list"> <li>Nikon<sup>®</sup> microscope models Upright Eclipse Ci and Inverted Ts2-FL  </li> <li>Eppendorf/BioRad PCR thermal cyclers  </li> <li>Kingfisher Automated Nucleic Acid Extraction System  </li> <li>Applied Biosystems™ 7500 Real-Time qPCR  </li> <li>Implen NanoPhotometer<sup>®</sup> NP80 Spectrometer  </li> <li>NucleoCounter<sup>®</sup> NC-202 </li> </ul> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="cba"><div id="em-layout-id_11ef1e-4b" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-row-has-bg em-layout-id_11ef1e-4b"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--none em-tablet-padding-top--xlarge em-tablet-padding-bottom--none em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column3339 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--large em-mobile-padding-left--none"> <h2 class="wp-block-heading" id="cba">Cell-based assays</h2> <p>Cell-based assays, or bioassays, are designed to measure the potency and stability of a drug substance or product and are important in establishing safety and efficacy profiles for biopharmaceuticals.</p> <p>PPD™ Laboratory services GMP lab has a 6,400-square-foot suite that is purpose-built and dedicated to bioassay development and testing. We work with customers to develop, transfer, optimize, qualify and validate potency assays that meet international regulatory and USP guidelines, in support of drug substance and drug product lot release and stability testing. Our lab can also create and maintain analytical cell banks for use in bioassay testing.</p> <p>Our cell-based assay lab operations are led by doctorate-level cell biologists, averaging 30 years of experience developing and validating biological and immunological assays to support the development and commercialization of a range of biotherapeutic products and vaccines.</p> <h3 class="wp-block-heading">Our capabilities include:</h3> <ul class="wp-block-list"> <li>Cell bank creation/qualification</li> <li>Qualification of critical reagents</li> <li>Method development/validation</li> <li>GMP release and stability testing of drug substance and drug product</li> <li>Statistical analysis (JMP, PLA)</li> </ul> <h3 class="wp-block-heading">Our methods include:</h3> <ul class="wp-block-list"> <li>Cell proliferation and cytotoxicity</li> <li>Cytokine and metabolite effector phosphorylation</li> <li>Enzyme function assays</li> <li>Reporter gene assays</li> <li>Transfection/infection efficiency</li> <li>Binding</li> <li>Protein expression</li> </ul> </div></div> <div class="wp-block-emagine-column emagine-column1962 inner-column-2"><div class="em-inside-inner-col em-padding-top--small em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Key instrumentation:</h3> <ul class="wp-block-list"> <li>Molecular Devices instrumentation: SpectraMax<sup>®</sup> M3, M5, M5e, Flexstation and I3 plate readers</li> <li>Perkin Elmer<sup>®</sup> EnVision<sup>®</sup> XCite multi-mode plate reader</li> <li>Biotek<sup>®</sup> Cytation 5 Cell Imaging Multi-Mode Reader</li> <li>FACSCanto™ II dual laser with 3 laser lines (405, 488, 633)</li> <li>Beckman Cytoflex with 3 laser lines (488, 638, 405)</li> <li>MSD<sup>®</sup> SECTOR<sup>®</sup> 600</li> <li>Digital microscopes</li> <li>Applied Biosystems™ qPCR</li> <li>ThermoFisher Scientific QuantStudio™ 7 Flex Real-Time qPCR</li> <li>Bio-Rad QX200 Droplet Digital PCR</li> <li>Proteinsimple Wes™ Western blotting</li> <li>Vi-CELL<sup>®</sup> Counter</li> <li>Tecan<sup>®</sup> FreedomEVO<sup>®</sup> 150 liquid handler</li> <li>JMP<sup>®</sup>, StatLIA<sup>®</sup>, PLA (Stegmann) software</li> </ul> <figure class="wp-block-image size-large is-resized hide-on-mobile"><img decoding="async" src="https://www.ppd.com/wp-content/uploads/2019/12/ath_0980.png" alt="two scientists looking at lab samples" style="width:621px;height:750px"/></figure> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="EandL"><div id="em-layout-id_287ec6-20" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_287ec6-20"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column9301 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading">Extractables and leachables</h2> <p>The dedicated and highly specialized extractables and leachables (E&L) team in our GMP lab has more than 15 years of experience providing wide-ranging support for E&L studies, including overall study design/consulting, container/closure selection and manufacturing process qualification and validation. Our E&L team and toxicology experts work with you to make informed decisions on which extractable compounds will be monitored as leachables in long-term stability studies, development of extractable and leachable methods, leachable stability testing, batch extractables testing and USP compendia testing support.</p> <p>Our lab employees belong to various industry groups, participate in E&L conferences and are regular contributors to industry publications on E&L. Our extensive experience designing and conducting E&L studies across a range of container/closure and device materials and across nearly all routes of administration has positioned PPD Laboratory services as a leading industry expert in this highly technical field.</p> <p>We can deliver an integrated toxicity/safety evaluation by experienced and American Board of Toxicology-certified toxicologists familiar with the application of Product Quality Research Institute (PQRI) and other industry recommendations.</p> <h3 class="wp-block-heading">Material evaluation expertise:</h3> <ul class="wp-block-list"> <li>A wide variety of parenteral product components including devices and containers/closures</li> <li>Inhalation devices for delivery to lung and nasal mucosa: <ul class="wp-block-list"> <li>Dry powder inhalers (DPI)</li> <li>Pressurized metered-dose inhalers (pMDI)</li> <li>Nasal spray solution/suspension bottles and pumps </li> </ul> </li> <li>Materials types, product dosage forms and routes of administration: <ul class="wp-block-list"> <li>Transdermal products</li> <li>Oral products</li> <li>Labeling</li> <li>Adhesives</li> </ul> </li> <li>Medical devices including implantables</li> <li>Primary and secondary packaging and manufacturing components</li> <li>Special case compounds: <ul class="wp-block-list"> <li>N-nitrosamines</li> <li>Mercaptobenzothiazole (MBT)</li> <li>Polyaromatic hydrocarbons (PAH)</li> <li>Other genotoxic impurities</li> </ul> </li> </ul> <p></p> </div></div> <div class="wp-block-emagine-column emagine-column7245 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--medium em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Our services:</h3> <ul class="wp-block-list"> <li>Controlled extraction study (CES) for material profiling</li> <li>Leachable studies</li> <li>Unknown leachable identification</li> <li>Extractable profile and toxicological assessment</li> <li>Silicone oil testing</li> </ul> <h3 class="wp-block-heading">Key instrumentation:</h3> <ul class="wp-block-list"> <li>Liquid chromatography/mass spectrometry (LC/MS): <ul class="wp-block-list"> <li>AB SCIEX TripleTOF™ 5600</li> <li>Agilent 6545 QTOF</li> <li>Other vendor platforms and models of single- and triple-quad LC/MS systems</li> </ul> </li> <li>Gas chromatography/mass spectrometry (GC/MS): <ul class="wp-block-list"> <li>Multiple single-quad GC/MS systems with headspace, direct injection and prep station capability</li> <li>Agilent 7890B / 5977 A/B MSD and other models Inductively coupled plasma mass spectrometry</li> </ul> </li> <li>Inductively coupled plasma mass spectrometry (ICP-MS): <ul class="wp-block-list"> <li>Multiple inductively coupled plasma-optical emission spectrometry (ICP-OES) and mass spectrometry (MS) systems of various models and vendor platforms</li> </ul> </li> <li>Dedicated lab areas for material extraction, preparation and analysis</li> <li>Stable Micro Systems texture analyzer model TA.XTplusC</li> </ul> <figure class="wp-block-image size-large hide-on-mobile"><img fetchpriority="high" decoding="async" width="640" height="427" src="/wp-content/uploads/2020/03/middleton-1330-Edit-1.jpeg" alt="GMP Lab" class="wp-image-7913" srcset="https://www.ppd.com/wp-content/uploads/2020/03/middleton-1330-Edit-1.jpeg 640w, https://www.ppd.com/wp-content/uploads/2020/03/middleton-1330-Edit-1-300x200.jpeg 300w, https://www.ppd.com/wp-content/uploads/2020/03/middleton-1330-Edit-1-60x40.jpeg 60w" sizes="(max-width: 640px) 100vw, 640px" /></figure> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="msse"><div id="em-layout-id_d66734-57" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-row-has-bg em-layout-id_d66734-57"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column959 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--large em-mobile-padding-left--none"> <h2 class="wp-block-heading">Mass spectrometry and structural elucidation</h2> <p>The mass spectrometry (MS) team in the GMP lab works closely with our method development and stability areas to identify critical degradation products that emerge over the course of the development cycle.</p> <p>We use advanced instrumentation to identify and characterize active components as well as process impurities during the early phases of development for small and large molecules.</p> <p>To enable the analysis of compounds not compatible with traditional LC-MS, we have developed two-dimensional liquid chromatography mass spectrometry (2D-LC/MS) methodologies for online separation and detection of compounds.</p> <h3 class="wp-block-heading">Our service offering includes:</h3> <ul class="wp-block-list"> <li>LC-MS method development and validation of small molecules and large biomolecules, e.g. oligonucleotides, proteins, and monoclonal antibodies</li> <li>Characterization of active pharmaceutical ingredients (APIs), products, reference standards and other pharmaceutical ingredients</li> <li>Quantitative analysis of APIs, drug products, impurities using LC-UV/MS (single quadrupole or triple quadrupole mass spectrometers)</li> <li>Impurity and degradation product identification and structural elucidation using high resolution mass spectrometry</li> <li>Accurate mass determination for small molecules</li> <li>Molecular weight determination for large biomolecules</li> <li>High resolution mass spectrometry since we can use both Orbitrap and ToF MS</li> <li>Sequence confirmation for oligonucleotides</li> </ul> </div></div> <div class="wp-block-emagine-column emagine-column8381 inner-column-2"><div class="em-inside-inner-col em-padding-top--small em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Key instrumentation:</h3> <ul class="wp-block-list"> <li>Thermo Scientific™ Q Exactive™ Plus with BioPharma Option mass spectrometer coupled with Vanquish UHPLC</li> <li>Obtrap Exploris™ 240 with BioPharma Option mass spectrometer coupled with Vanquish UHPLC</li> <li>Waters BioAccord LC-MS system</li> <li>Waters QDa detector coupled with ultra-high performance liquid chromatography (ACQUITY UPLC H-class Bio System)</li> <li>Waters ACQUITY<sup>®</sup> TQ Detector LC-MS/MS coupled with UPLC</li> <li>AB Sciex 5600+ Triple TOF (MS) coupled with 2D-UHPLC</li> <li>Applied Biosystems/MDS Sciex QTRAP<sup>®</sup> LC-MS/MS</li> <li>Applied Biosystems/MDS Sciex API LC-MS/MS</li> <li>Agilent single Quadrupole LC-MS</li> </ul> <figure class="wp-block-image size-large hide-on-mobile"><img decoding="async" width="640" height="427" src="/wp-content/uploads/2020/03/middleton-1955.jpeg" alt="GMP Lab" class="wp-image-7914" srcset="https://www.ppd.com/wp-content/uploads/2020/03/middleton-1955.jpeg 640w, https://www.ppd.com/wp-content/uploads/2020/03/middleton-1955-300x200.jpeg 300w, https://www.ppd.com/wp-content/uploads/2020/03/middleton-1955-60x40.jpeg 60w" sizes="(max-width: 640px) 100vw, 640px" /></figure> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="micro"><div id="em-layout-id_7195f4-ad" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_7195f4-ad"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column6699 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading">Microbiology</h2> <p>PPD Laboratory services’ GMP lab provides a wide range of microbiological testing. All tests are performed under GMP requirements and comply with applicable compendia (USP/EP/JP) requirements. We also accommodate specialty testing and projects of various sizes to suit a particular need. Our facility includes a 5,000-square-foot HEPA-filtered, restricted-access microbiology lab with a separate ISO Class 8 sterility suite.</p> <h3 class="wp-block-heading has-black-color has-text-color">Key instrumentation:</h3> <ul class="wp-block-list"> <li>Seven ISO class 5 biosafety cabinets</li> <li>A variety of incubators with 24/7 monitoring</li> <li>Walker Barrier Systems Half-suit Isolator</li> <li>Two Bioquell Qube sterility testing isolators</li> <li>PTI VeriPac 445 Micro Leak Detection System</li> <li>LIGHTHOUSE FMS-Oxygen Headspace Analyzer</li> <li>Two ProtoCOL SR zone readers</li> <li>Charles River EndoScan-V™</li> </ul> <figure class="wp-block-image size-large hide-on-mobile"><img decoding="async" width="834" height="1024" src="https://www.ppd.com/wp-content/uploads/2022/07/ppd-gmp-lab-834x1024.jpg" alt="" class="wp-image-23282" srcset="https://www.ppd.com/wp-content/uploads/2022/07/ppd-gmp-lab-834x1024.jpg 834w, https://www.ppd.com/wp-content/uploads/2022/07/ppd-gmp-lab-244x300.jpg 244w, https://www.ppd.com/wp-content/uploads/2022/07/ppd-gmp-lab-768x943.jpg 768w, https://www.ppd.com/wp-content/uploads/2022/07/ppd-gmp-lab-41x50.jpg 41w, https://www.ppd.com/wp-content/uploads/2022/07/ppd-gmp-lab.jpg 960w" sizes="(max-width: 834px) 100vw, 834px" /></figure> </div></div> <div class="wp-block-emagine-column emagine-column2139 inner-column-2"><div class="em-inside-inner-col em-padding-top--small em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--medium em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Our service offering includes:</h3> <p><strong>Compendial USP/EP/JP microbiology testing</strong></p> <ul class="mt-0 wp-block-list"> <li>Sterility Testing</li> <li>Microbial Limits</li> <li>Bioburden</li> <li>Antimicrobial Efficacy Testing</li> <li>Bacterial Endotoxin Testing <ul class="wp-block-list"> <li>Kinetic Chromogenic</li> <li>Kinetic Turbidimetric</li> <li>Gel Clot</li> </ul> </li> <li>Water Activity</li> <li>Dye Ingress – Qualitative probabilistic</li> <li>Laser based Oxygen Headspace Analysis – Quantitative Deterministic</li> <li>Vacuum Decay – Quantitative Deterministic</li> </ul> <p><strong>Water testing</strong></p> <ul class="mt-0 wp-block-list"> <li>Total Plate Count</li> <li>Total Organic Carbon</li> <li>Conductivity</li> <li>pH</li> </ul> <p><strong>Specialized microbiology studies</strong></p> <ul class="mt-0 wp-block-list"> <li>Intravenous (IV) Microbial Challenge Hold Time Studies</li> <li>Bacteriophage Plaque Assay</li> <li>Low Endotoxin Recovery (LER) Studies</li> <li>Antibiotic Potency Assay</li> <li>Disinfectant Efficacy Studies</li> </ul> <p><strong>Product type experience</strong></p> <ul class="mt-0 wp-block-list"> <li>Sterile injectable products</li> <li>Inhaled pharmaceuticals</li> <li>Oral and topical pharmaceuticals</li> <li>Over-the-counter (OTC) and consumer products</li> <li>Raw materials and active pharmaceutical ingredients (APIs)</li> </ul> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="pmc"><div id="em-layout-id_58d1b5-7c" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-row-has-bg em-layout-id_58d1b5-7c"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column8614 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading" id="pmc">Physical chemistry and material characterization</h2> <p>PPD Laboratory services’ GMP lab provides a complete selection of physical and chemical characterization technologies to support customers’ drug development programs. Our services support active pharmaceutical ingredient (API) analytical profiling, drug product preformulation and formulation development programs.</p> <p>Our experts can develop methods and help customers design a comprehensive program that will proactively address full characterization of a variety of materials. In addition, these services can be combined with other analytical techniques to help you solve problems observed in the later phases of the drug development process.</p> <figure class="wp-block-image size-full hide-on-mobile"><img loading="lazy" decoding="async" width="691" height="461" src="https://www.ppd.com/wp-content/uploads/2023/03/middleton-1775.Xray_.jpg" alt="" class="wp-image-24926" srcset="https://www.ppd.com/wp-content/uploads/2023/03/middleton-1775.Xray_.jpg 691w, https://www.ppd.com/wp-content/uploads/2023/03/middleton-1775.Xray_-300x200.jpg 300w, https://www.ppd.com/wp-content/uploads/2023/03/middleton-1775.Xray_-60x40.jpg 60w" sizes="(max-width: 691px) 100vw, 691px" /></figure> </div></div> <div class="wp-block-emagine-column emagine-column4704 inner-column-2"><div class="em-inside-inner-col em-padding-top--small em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--medium em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Our service offering includes:</h3> <ul class="wp-block-list"> <li>X-ray powder diffraction (XRPD) for form identification, quantitative analysis, and crystallinity/amorphous determination; both reflection and transmission mode capable; VT/RH analysis available</li> <li>Melting point, enthalpy, polymorph and phase transition determination by differential scanning calorimetry thermal analysis (DSC), thermal gravimetric analysis (TGA)</li> <li>Particle-size analysis (laser diffraction and dynamic light scatter)</li> <li>Specific surface area by gas  </li> <li>Microscopy services, including Raman-microscopy for particulate identification.</li> <li>Particulate enumeration using the Beckman HIAC liquid particle counter or the ProteinSimple MFI™ system</li> <li>Solution properties – solubility, zeta potential, viscosity, density, etc.</li> <li>Water content, water activity, and hygroscopicity</li> <li>Other assays including refractive index, total organic carbon, and FTIR</li> </ul> <h3 class="wp-block-heading">Key instrumentation:</h3> <ul class="wp-block-list"> <li>Industry standard equipment available for all testing per USP and EP recommendations and regulatory requirements</li> </ul> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="raw-materials-testing"><div id="em-layout-id_1ece5e-14" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_1ece5e-14"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column8244 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading">Raw materials testing</h2> <p>PPD Laboratory services’ GMP lab provides a comprehensive suite of compendial and raw material testing in order to support all of our clients’ programs – from pre-clinical to commercial. Our team has extensive experience in routine testing per the USP, EP, & JP, and has evaluated other compendia, including the ChP, to provide testing services to clients.</p> <h3 class="wp-block-heading">Key services</h3> <ul class="wp-block-list"> <li>Method development and validation or method transfer</li> <li>Compendial method verification</li> <li>Routine release testing</li> </ul> <h4 class="wp-block-heading">Our offerings include monograph testing and physical testing</h4> <ul class="wp-block-list"> <li>Particle size distribution</li> <li>X-ray powder diffraction</li> <li>Pharmaceutical packaging and closure testing from the various compendia.</li> </ul> <p>We offer guaranteed testing turnaround times with expedited testing options available to meet client deadlines. Our experienced raw material testing team manages programs with dedicated technical and project managers for all client studies.</p> <figure class="wp-block-image size-full hide-on-mobile"><img loading="lazy" decoding="async" width="800" height="533" src="https://www.ppd.com/wp-content/uploads/2022/11/gmp-lab-athlone-ireland_0614.jpg" alt="gmp lab athlone ireland" class="wp-image-24152" srcset="https://www.ppd.com/wp-content/uploads/2022/11/gmp-lab-athlone-ireland_0614.jpg 800w, https://www.ppd.com/wp-content/uploads/2022/11/gmp-lab-athlone-ireland_0614-300x200.jpg 300w, https://www.ppd.com/wp-content/uploads/2022/11/gmp-lab-athlone-ireland_0614-768x512.jpg 768w, https://www.ppd.com/wp-content/uploads/2022/11/gmp-lab-athlone-ireland_0614-60x40.jpg 60w" sizes="(max-width: 800px) 100vw, 800px" /></figure> </div></div> <div class="wp-block-emagine-column emagine-column8049 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--medium em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Compendial analysis: USP, EP, JP, and others</h3> <p class="mb-0 pb-0"><strong>Wet chemistry testing</strong></p> <ul class="wp-block-list"> <li>Identification</li> <li>Impurities limit tests (e.g. lead, arsenic)</li> <li>Assay by titration (manual and potentiometric)</li> <li>Gravimetric analysis (e.g. residue on ignition, loss on drying)<br></li> </ul> <p class="mb-0 pb-0"><strong>Instrument-based testing</strong></p> <ul class="wp-block-list"> <li>FTIR, UV-Vis</li> <li>TOC</li> <li>Atomic Absorption Spectroscopy (flame, furnace, and hydride generation)</li> <li>Optical rotation</li> <li>Specific gravity / density</li> <li>Refractive index</li> <li>Chromatography (LC, GC, IC), including post column derivatization for compendial ninhydrin positive substance testing of amino acids</li> <li>Water testing <ul class="wp-block-list"> <li>Karl Fisher, water activity, dynamic vapor sorption</li> </ul> </li> <li>Osmolality</li> </ul> <p class="mb-0 pb-0"><strong>Performance characteristic testing</strong></p> <ul class="wp-block-list"> <li>Specific surface area</li> <li>Viscosity</li> </ul> <p class="mb-0 pb-0"><strong>Container, closure and packaging testing</strong></p> <ul class="wp-block-list"> <li>Glass containers (USP <660>, EP 3.2.1, JP 7.01)</li> <li>Plastic containers (USP <661>, EP 3.2.2, JP 7.02) <ul class="wp-block-list"> <li>Early adoption of USP <661.2> and <661.2></li> </ul> </li> <li>Elastomeric closures (USP <381>, EP 3.2.2, JP 7.03) <ul class="wp-block-list"> <li><a href="https://www.ppd.com/our-solutions/ppd-laboratories/gmp-lab/capabilities/#pmc">Physical chemistry</a></li> <li><a href="https://www.ppd.com/our-solutions/ppd-laboratories/gmp-lab/capabilities/#micro">Microbiology</a></li> </ul> </li> </ul> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="stability"><div id="em-layout-id_6f2c5a-56" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-row-has-bg em-layout-id_6f2c5a-56"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column1674 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading">Stability</h2> <p>We provide a full complement of GMP analytical testing resources and expertise to support development as well as commercial stability studies for APIs and drug products in virtually all dosage forms and delivery systems. Whether your program requires stability studies that follow the guidelines of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) or you need a customized program, our experts can help. We’ll work closely with you to design a program that meets your requirements.</p> <h3 class="wp-block-heading">Our service offering includes:</h3> <ul class="wp-block-list"> <li>ICH and customized testing for stability programs for APIs and finished product for small molecules and biologics in any dosage form/device/delivery system</li> <li>Drug Enforcement Agency (DEA)-compliant stability programs</li> <li>Photostability studies</li> <li>Temperature cycling, freeze-thaw and shipping studies</li> <li>Excipient and prototype formulation stability testing</li> <li>Evaluation of stability data using ICH Guideline Q1E</li> </ul> </div></div> <div class="wp-block-emagine-column emagine-column1325 inner-column-2"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--large em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Key instrumentation and facilities:</h3> <ul class="wp-block-list"> <li>ICH- and DEA-compliant facilities</li> <li>More than 100,000 cubic feet of walk-in and reach-in stability storage space at two geographic locations with space for an additional 75,000 sq. ft. of storage chambers</li> <li>Customized electronic sample tracking tool monitored by computerized alarm system</li> <li>Chamber condition limit alarm with automatic telephone call-out to staff (24/7)</li> <li>Full generator backup</li> <li>Standard chamber conditions range from -80°C to 50°C with 15% to 75% relative humidity (RH)</li> <li>Customized temperature and relative humidity conditions can be accommodated upon request</li> <li>Photostability chamber with white (visible) and near UV (UV-A) exposure options</li> </ul> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull" id="reference-material-fill-and-distribution"><div id="em-layout-id_674d8d-c1" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_674d8d-c1"><div class="em-row-column-wrap em-has-2-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--xlarge em-mobile-padding-bottom--default alignwide"> <div class="wp-block-emagine-column emagine-column6982 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading">Reference material fill and distribution</h2> <p>PPD Laboratory services’ GMP lab has more than 25 years of experience in supply chain management and logistics, including material storage, dispensing, inventory management and distribution. We have performed storage, portioning and distribution services for more than 100 pharmaceutical customers with compounds at various storage conditions and compound type, including active pharmaceutical ingredients (APIs), raw materials, finished goods and materials, selective dangerous goods/hazardous materials and controlled substance classes I-V.</p> <p>Our dedicated and highly trained team provides comprehensive services for aliquoting and repackaging  diverse liquid and dry materials in the following environments: aseptic technique fills with sterile materials, N2, Biosafety Level 2 (BSL2), controlled substances within a dedicated laboratory space, and ISO class 5 biosafety cabinets with GMP quality control. We can accommodate all types of containers and sizes.</p> <p>We store or ship your critical materials at a full range of temperatures, from ambient through cryogenic, in controlled, GMP environments with full audit trail and material traceability, minimizing time-out-of-environment. All storage units are validated, and temperatures are mapped and controlled with ongoing maintenance from our in-house metrology group. Our storage and distribution facilities have controlled access with 24/7 temperature monitoring.</p> <figure class="wp-block-image size-full hide-on-mobile"><img loading="lazy" decoding="async" width="760" height="475" src="https://www.ppd.com/wp-content/uploads/2023/12/reference-material-fill-and-distribution.jpg" alt="Trained team in reference material fill and distribution GMP lab." class="wp-image-27184" srcset="https://www.ppd.com/wp-content/uploads/2023/12/reference-material-fill-and-distribution.jpg 760w, https://www.ppd.com/wp-content/uploads/2023/12/reference-material-fill-and-distribution-300x188.jpg 300w, https://www.ppd.com/wp-content/uploads/2023/12/reference-material-fill-and-distribution-60x38.jpg 60w" sizes="(max-width: 760px) 100vw, 760px" /></figure> </div></div> <div class="wp-block-emagine-column emagine-column3794 inner-column-2"><div class="em-inside-inner-col em-padding-top--small em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--large em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h3 class="wp-block-heading">Our services include:</h3> <p><strong>Secure storage</strong></p> <ul class="mt-0 wp-block-list"> <li>150,000+ cubic feet of storage capacity</li> <li>Shared or client-dedicated storage options; dedicated units can be set for any storage condition</li> <li>Option to split material across storage units for risk mitigation</li> <li>Inventory monitoring with low quantity alert limits applied</li> </ul> <p><strong>Bulk material aliquoting</strong></p> <ul class="mt-0 wp-block-list"> <li>Biosafety cabinet (BSC) hoods for aliquoting GMP fills of up to 50,000 vials per week</li> <li>Accommodate volumes as low as 10µl</li> <li>Package and label ambient and temperature sensitive materials up to -130 C on demand using unique IDs with electronic tracking. Inventory can be recorded in customer laboratory information management system (LIMS).</li> </ul> <p><strong>Global distribution</strong></p> <ul class="mt-0 wp-block-list"> <li>All packaging conducted at temperature with zero time out of environment pack and ship capabilities; client-specified packaging and shipping containers supported</li> <li>Accommodate customs and import regulations across Europe, APAC and Latin America</li> <li>Communication with customs brokers and secure clearance of international shipments prior to shipment</li> </ul> </div></div> </div></div></div> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_aabfa3-1f" class="em-row-layout-inner em-margin-top--none em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_aabfa3-1f"><div class="em-row-column-wrap em-has-1-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-inherit em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--xlarge em-padding-bottom--xlarge em-tablet-padding-top--xlarge em-tablet-padding-bottom--xlarge em-mobile-padding-top--default em-mobile-padding-bottom--xlarge alignwide"> <div class="wp-block-emagine-column emagine-column6110 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"> <h2 class="wp-block-heading has-text-align-center">Related resources</h2> <p class="has-text-align-center">Learn more about PPD Laboratory services’ GMP lab capabilities. </p> <div class="wp-block-emagine-columns alignfull"><div id="em-layout-id_2b3ce4-be" class="em-row-layout-inner em-margin-top--default em-margin-bottom--none em-tablet-margin-top--none em-tablet-margin-bottom--none em-mobile-margin-top--none em-mobile-margin-bottom--none em-layout-id_2b3ce4-be"><div class="em-row-column-wrap em-has-3-columns em-gutter-default em-row-valign-top em-row-layout-equal em-tab-layout-equal em-m-colapse-left-to-right em-mobile-layout-row em-padding-top--default em-padding-bottom--default em-tablet-padding-top--default em-tablet-padding-bottom--default em-mobile-padding-top--none em-mobile-padding-bottom--default alignfull"> <div class="wp-block-emagine-column emagine-column5351 inner-column-1"><div class="em-inside-inner-col em-padding-top--none em-padding-right--none em-padding-bottom--none em-padding-left--none em-tablet-padding-top--none em-tablet-padding-right--none em-tablet-padding-bottom--none em-tablet-padding-left--none em-mobile-padding-top--none em-mobile-padding-right--none em-mobile-padding-bottom--none em-mobile-padding-left--none"><a href="/resource/gmp-lab-overview-tech-sheet/" target="_blank" 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