Indena | Custom Services

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<section class="hero-page positive white" data-bg="white"> <div class="hero-page-wrapper"> <div class="hero-page-viewport hero-variation hero-page-gradient"> <div class="img-wrapper"> <div class="padding-ratio"> <picture class="img-fill"> <source srcset="https://www.indena.com/indena_files/2024/02/cdmo_hero_1920x1080.jpg" media="(min-width: 992px)"> <source srcset="https://www.indena.com/indena_files/2024/02/cdmo_hero-mobile_750x1300.jpg" media="(min-width: 320px)"> <img class="fill" src="https://www.indena.com/indena_files/2024/02/cdmo_hero_1920x1080.jpg" alt="CDMO SERVICE"> </picture> </div> </div> <div class="hero-page-text"> <div class="hero-page-title "> <nav class="breadcrumbs"> <ul class="page-tree"><li><a href="https://www.indena.com/ja/">ホームページ</a></li> <li>CDMO</li></ul> </nav> <p class="category">CDMO SERVICE</p> <h1 class="white-text">Unlock Next-Level Health Solutions</h1> </div> <div class="hero-page-content"> <p class="">Unlock Next-Level Health Solutions</p> </div> <div 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</a> </div> </div> <script> var popupCenter = function(url, title, w, h) { // Fixes dual-screen position Most browsers Firefox var dualScreenLeft = window.screenLeft !== undefined ? window.screenLeft : screen.left; var dualScreenTop = window.screenTop !== undefined ? window.screenTop : screen.top; var width = window.innerWidth ? window.innerWidth : document.documentElement.clientWidth ? document.documentElement.clientWidth : screen.width; var height = window.innerHeight ? window.innerHeight : document.documentElement.clientHeight ? document.documentElement.clientHeight : screen.height; var left = ((width / 2) - (w / 2)) + dualScreenLeft; var top = ((height / 3) - (h / 3)) + dualScreenTop; var newWindow = window.open(url, title, 'scrollbars=yes, width=' + w + ', height=' + h + ', top=' + top + ', left=' + left); // Puts focus on the newWindow if (window.focus) { newWindow.focus(); } }; </script> <a href="mailto:marketing@indena.com"><svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-contact"></use></svg><span>お問い合わせ</span></a> </div> </div> </div> </section> <div id="part_1" class="h2-anchor-wrapper padding-top offset-left offset-right" data-bg="white"> <h2 class="js-anchor" id="section_1">A NEW GENERATION OF CDMO SERVICES</h2> </div> <section id="part_2" class="complete-text-block negative-bottom offset-left offset-right white bg-grid " data-bg="white" > <div class="complete-text-block-wrapper"> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <div class="text-row"> <div class="left"> <h2>THE FORMULA FOR YOUR SUCCESS</h2> </div> <div class="right"> <p>With more than 100 years of pharmaceutical excellence and a cutting-edge vision of the future, Indena stands as the most reliable partner to design customized solutions for the development and manufacturing of natural derivatives and complex synthetic molecules.<br><strong><br>Research and curiosity, technology and development, mastery and human genius and obsession for excellence: these are the key factors in Indena’s CDMO activity – and successful partnerships.</strong></p> </div> </div> </div> </div> </section> <section id="part_3" class="video padding-top padding-bottom offset-left offset-right white" data-bg="white" > <div class="video-wrapper"> <div class="wd-video"> <div class="video-wrapper"> <iframe src="https://www.youtube-nocookie.com/embed/pUu3vHFjY2U?rel=0&fs=1" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe> </div> </div> </div> </section> <section id="part_4" class="complete-text-block offset-left offset-right white bg-grid " data-bg="white" > <div class="complete-text-block-wrapper"> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <div class="text-row"> <div class="left"> <h2>MEET INDENA<br>GAIN A PARTNER</h2> </div> <div class="right"> <p>The expertise of our R&D team, covering analytical and process development, guarantees the kind of support and results only an expert partner with a strong foundation in science can provide.<br><br>As a privately owned company with a solid financial position, Indena has the vision and the capability to adopt new technologies, capitalizing on decades of know-how in the field of complex molecules. <strong>Our long-term strategy and vision have established us as a prominent and highly reliable strategic partner for a new generation of CDMO services.</strong></p> </div> </div> </div> </div> </section> <div id="part_5" class="h2-anchor-wrapper padding-top offset-left offset-right" data-bg="white"> <h2 class="js-anchor" id="section_5">Research & Development</h2> </div> <section id="part_6" class="text-image-block padding-top offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>A LEADING CDMO AT YOUR SIDE</h3> <p>Since 1921, Indena has been continuously expanding its range of high-quality services for the benefit of its partners. Our goal is to offer custom development and manufacturing solutions that retain the highest quality standards while guaranteeing enhanced flexibility – processing molecules that can be naturally derived (from botanical sources or microbial fermentation), semisynthetic, or synthetic.<br /> <br /> We now manufacture 10 commercial and 12 clinical-phase HPAPIs, and continue to constantly innovate our suites for both HPAPIs and APIs to. Our plant in Settala, Italy currently handles substances with OEL as low as 1 ng/m<sup>3</sup>. <br /> <br /> We always put a dedicated CDMO division, supported by a strong R&D team, at our partners’ service, and promptly implement custom solutions for specific projects requiring dedicated equipment.</p> <a id="cta-textmedia-6" role="link" class="simple-cta" href="/innovation/rd/" target="_self"> <span class="label">DISCOVER OUR R&D</span><svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/a-leading-cdmo-at-your-side.jpg" alt="A LEADING CDMO AT YOUR SIDE"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_7" class="complete-text-block offset-left offset-right white bg-grid " data-bg="white" > <div class="complete-text-block-wrapper"> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <div class="text-row"> <div class="left"> <h2>READY FOR THE GROWING HPAPI MARKET</h2> </div> <div class="right"> <p>The increasing number of oncology NCEs and antibody-drug conjugates, coupled with a growing focus on personalized medicine, is shaping the demand for CDMO services. The HPAPI market is undergoing a shift towards NCEs characterized by higher potency, growing molecular diversity and segmentation for specific populations.<br><br>Unlike newcomers in the field, Indena can count on an extensive know-how in safely handling HPAPIs, complemented by state-of-the-art equipment and installations. Within its long-term strategy, Indena has kept ahead of the curve by timely investing in specialized containment facilities that guarantee both employees and the external environment are safe from exposure, capitalizing on more than 30 years of know-how in high containment.</p> </div> </div> </div> </div> </section> <section id="part_18" class="text-image-block padding-top small-padding-bottom-desk offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>EXPERTS IN FERMENTATION</h3> <p>Indena’s fermentation department offers advanced capabilities in bio-transformation and secondary metabolite production using living cells. This expertise allows us to produce critical components in-house, such as toxins for Antibody Drug Conjugate (ADC) payloads, ensuring a fully integrated and independent supply chain. <br /> <br /> With a deep mastery of GMP microbial fermentation and high-containment lines for downstream processing, we offer unmatched reliability and safety for precision fermentation and HPAPI development.</p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2024/11/cdmo-fermentatori_852x852.jpg" alt="EXPERTS IN FERMENTATION"> <div class="img-loader"></div> </div> </div> </div> </section> <div id="part_8" class="h2-anchor-wrapper padding-bottom offset-left offset-right" data-bg="white"> <h2 class="js-anchor" id="section_8">Technology & Know-how</h2> </div> <section id="part_9" class="complete-text-block offset-left offset-right white bg-grid " data-bg="white" > <div class="complete-text-block-wrapper"> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <div class="text-row"> <div class="left"> <h2>OUR DOUBLE COMMITMENT: TECHNOLOGY AND KNOW-HOW </h2> </div> <div class="right"> <p>In an ever-evolving context where even a universally accepted definition for HPAPI has yet to be established, contract manufacturers must continuously invest in new specific facilities for this type of substance. Well aware of this, Indena has long been committed to advancing its CDMO services in this direction, investing in know-how, personnel, and cutting-edge equipment. <br><br>Our latest expansion includes a state-of-the-art, 400-m<sup>2</sup> R&D laboratory, equipped with 12 bench-top fume hoods, 2 walk-in fume hoods, a laminar flow fume hood, and 2 gloveboxes for up to 15 of the R&D scientists in our team of 70 experts. Additionally, a new industrial GMP line with reactors up to 10,000 liters enhances our capacity to produce and commercialize a wide range of regular APIs and HPAPIs. <br><br>With this proactive approach to innovation, we continue to stay ahead of market needs, offering unparalleled technological solutions and expertise to our CDMO clients.<span></span></p> </div> </div> </div> </div> </section> <section id="part_10" class="text-image-block offset-left offset-right white specular " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>SAFETY FIRST, INNOVATION ALWAYS: FROM HPAPIs TO ADCs</h3> <p>The lower the OEL, the more potent the substance – and the greater the need for rigorous containment. Manufacturers must often adopt a conservative approach to ensure safety, particularly when dealing with early-stage NCEs, where data may be lacking to properly classify a substance as an HPAPI.<br /> <br /> Indena, as a highly reliable Western European API producer, is equipped to handle substances with an OEL as low as 1 ng/m³, irrespective of their source. This includes toxin-based payloads for ADCs, supported by backward integration on fermentation and freeze-drying in high containment. <br /> <br /> Indeed, having built a strong expertise in HPAPIs, Indena is now expanding its focus to ADCs – a promising area of targeted therapy that combines the specificity of monoclonal antibodies with the cytotoxic power of chemotherapeutic drugs, offering a more precise and potentially less toxic treatment approach.</p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/spcialized-and-versatile-all-on-one-site-2.jpg" alt="SAFETY FIRST, INNOVATION ALWAYS: FROM HPAPIs TO ADCs"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_20" class="text-image-block offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>STATE-OF-THE-ART EQUIPMENT IMPLEMENTATION</h3> <p>Indena’s main production site is equipped with a GMP Pilot plant featuring advanced capabilities, including 2 1,000-liter stainless steel reactors, 400- and 1,000-liter glass-lined reactors, a 250-liter hastelloy reactor for temperatures between -80 °C to +200 °C, a 500-liter chromatographic column, and a hastelloy centrifuge.<br /> <br /> A significant expansion of the P8 plant began in early 2024, designed to increase the capacity for chemical synthesis and reactions 10-fold by early 2025, thus enabling larger-scale production of HPAPIs, from small molecules to OEB5, as well as a greater output of products currently produced in other departments.<br /> <br /> In addition, new cutting-edge technologies for chemical synthesis and purification of APIs and HPAPIs will be introduced, including centrifugation under containment (reverse bag centrifuge), reactor loading under containment (glove boxes), isolation and drying on a filter dryer, and purification using 2,000 low/medium pressure columns (up to 9 bars). A newly acquired Biazzi hydrogenator, capable of operating at up to 10 barg, will further enhance production capabilities.</p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2024/11/cdmo-pilota-pharma_852x852.jpg" alt="STATE-OF-THE-ART EQUIPMENT IMPLEMENTATION"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_11" class="text-image-block offset-left offset-right white specular " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>SPECIALIZED AND VERSATILE, ALL ON ONE SITE </h3> <p>On top of our focus on HPAPIs, we have leading expertise in the pre-formulation of poorly soluble APIs. Our combination of multiple, highly specialized technologies in one site allows us to optimize the supply chain: for example, we are able to carry out the synthesis of an API and the subsequent spray drying step using organic solvents, also in the presence of excipients to obtain a pre-formulated drug product. Indena is equipped with development- and commercial-scale spray dryers to provide clinical and commercial volumes. These activities are fully supported by our analytical team. In addition to spray drying, we have proprietary technologies to obtain solid amorphous dispersion (such as Indena Phytosome™) available.<br /> <br /> Indena has recently opened a multipurpose pilot GMP plant for productions of clinical and commercial small-scale; we are also currently implementing additional synthetic capacity, to anticipate future market demand.<br /> In the past few years, Indena has upgraded its fermentation capacity, in a multipurpose plant that can also handle toxic compounds. Currently, the plant is equipped with 100-, 1,000- and 20,000-liter fermenters. A dedicated biotech team now supports development and scale-up activities, assisting the technology transfer to production. <br /> </p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/spcialized-and-versatile-all-on-one-site-1.jpg" alt="SPECIALIZED AND VERSATILE, ALL ON ONE SITE "> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_12" class="text-image-block offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>EMPOWERING EXCELLENCE THROUGH OUR PEOPLE</h3> <p>At Indena, we see ourselves as strategic partners, going beyond the traditional client-supplier relationship by fully committing to the development of new HPAPIs and APIs, from early clinical stages through to commercial-scale manufacturing. This commitment is supported by continuous investments in innovative technologies and services, ensuring we meet and exceed our clients’ expectations.<br /> <br /> However, the true strength of our CDMO services lies in our people. At Indena, we combine the lifelong professional experience of seasoned experts with the fresh perspectives and enthusiasm of young scientists. This unique blend of talent ensures that we deliver exceptional results, backed by a corporate culture rooted in quality and rigorous HSE (Health, Safety, and Environment) policies.</p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/our-commitment-to-you.jpg" alt="EMPOWERING EXCELLENCE THROUGH OUR PEOPLE"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_21" class="complete-text-block offset-left offset-right white " data-bg="white" > <div class="complete-text-block-wrapper"> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <div class="text-row"> <div class="left"> <h2>COMPREHENSIVE REGULATORY ENGAGEMENT</h2> </div> <div class="right"> <p>Our strong regulatory department is a cornerstone of our ability to deliver high-quality services to clients, navigating complex and ever-evolving global health regulations. <br><br>By maintaining ongoing interactions with key authorities such as the FDA (U.S. Food and Drug Administration), EMA (European Medicines Agency), AIFA (Italian Medicines Agency), ANSN (French National Agency for Medicines and Health Products Safety), and PDMA (Pharmaceuticals and Medical Devices Agency in Japan), our experts ensure that all aspects of our operations are not only safe and efficient but also fully compliant with the highest industry standards.<span></span></p> </div> </div> </div> </div> </section> <section id="part_19" class="text-image-block small-padding-bottom-desk offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>SUSTAINABILITY & BUSINESS CONTINUITY</h3> <p>Sustainability is at the heart of all our operations, not only to benefit the environment but also to ensure business continuity through efficient resource management and compliance with EU climate change policies. <br /> <br /> Our commitment to reducing fossil fuel consumption and enhancing energy efficiency is evident across our facilities, equipped with over 4 MW of photovoltaic systems, projected to generate 4,000,000 kWh of clean energy annually. We also invest in high-efficiency chillers, nitrogen production systems, and heat pumps to optimize water and heat usage, contributing to our broader sustainability goals.<br /> <br /> As further evidence of our environmental stewardship, our portfolio includes innovative, sustainable products such as plant-based squalene, produced from Amaranthus seeds instead of shark liver; resiniferatoxin, derived from the sustainable cultivation of the Euphorbia plant; and cytisine, supported by a controlled, certified, and fully traced supply chain. <br /> <br /> These efforts, along with our EcoVadis Bronze Medal certification, position Indena as a leader in sustainability, ensuring long-term reliability and success for our clients.<br /> <br /> <strong>A few examples of recent developments</strong> <br /> • A new API to treat hematologic malignancies<br /> • Constantly innovating the HPAPI market<br /> </p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2024/11/cdmo-pannelli_852x852.jpg" alt="SUSTAINABILITY & BUSINESS CONTINUITY"> <div class="img-loader"></div> </div> </div> </div> </section> <div id="part_13" class="h2-anchor-wrapper padding-top padding-bottom offset-left offset-right" data-bg="white"> <h2 class="js-anchor" id="section_13">Download</h2> </div> <section id="part_14" class="downloads offset-left offset-right white" data-bg="white" > <div class="downloads-wrapper"> <div class="download-row"> <a id="open-file-14-1" role="link" target="_blank" href="https://www.indena.com/indena_files/2024/03/wp_cdmo_2024.pdf"> <div class="left"><span class="title">Whitepaper CDMO</span><span class="text"><br>[PDF - 3.26 MB]</span></div> <div class="right"> <span class="dl-pill"> <span class="label">ダウンロード</span><svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-download"></use></svg> </span> </div> </a> </div> <div class="download-row"> <a id="open-file-14-2" role="link" target="_blank" href="https://www.indena.com/indena_files/2021/01/white_paper_pharma.pdf"> <div class="left"><span class="title">Whitepaper Pharma</span><span class="text"><br>[PDF - 1.16 MB]</span></div> <div class="right"> <span class="dl-pill"> <span class="label">ダウンロード</span><svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-download"></use></svg> </span> </div> </a> </div> </div> </section> <section id="part_15" class="text-page offset-left white " data-bg="white" > <div class="text-page-wrapper"> <div class="container-fluid"> <div class="row"> <div class="col-10 offset-1"> <h2>Few examples recently developed:</h2> </div> </div> </div> </div> </section> <section id="part_16" class="carousel-full-card offset-left offset-right white" data-bg="white" > <div class="carousel-full-card-wrapper"> <div class="carousel-full-card-content autoplay"> <div class="swiper-container"> <div class="swiper-wrapper"> <div class="swiper-slide carousel-full-card-slide"> <div class="full-card-wrapper"> <div class="full-card-content"> <div class="img-zone"> <div class="img-wrapper"> <picture> <source data-srcset="https://www.indena.com/indena_files/2020/12/highlights-slider-lg-2.jpg" media="(min-width: 768px)"> <source data-srcset="https://www.indena.com/indena_files/2020/12/highlights-slider-sm-2.jpg" media="(min-width: 320px)"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/highlights-slider-lg-2.jpg" alt="highlights-slider-lg-2"> <div class="img-loader"></div> </picture> </div> </div> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <div class="text-wrapper"> <h3>A new API to treat hematologic malignancies.</h3> <p class="text">A REPURPOSED API TO TREAT HEMATOLOGIC MALIGNANCIES AND SUPPORT STEM CELL TRANSPLANTATION<br><br /> Leveraging research capabilities, technical infrastructure and our team’s specialized know-how, Indena joined forces with one of its outstanding partners to redesign the synthesis of a repurposed, totally synthetic API that helps fight cancers affecting the production and function of blood cells. The project allowed us to develop and validate a robust process and to provide a sustainable supply of this highly potent API.</p> </div> </div> </div> </div> </div> <div class="swiper-slide carousel-full-card-slide"> <div class="full-card-wrapper"> <div class="full-card-content"> <div class="img-zone"> <div class="img-wrapper"> <picture> <source data-srcset="https://www.indena.com/indena_files/2020/12/highlights-slider-lg-3-1.jpg" media="(min-width: 768px)"> <source data-srcset="https://www.indena.com/indena_files/2020/12/highlights-slider-sm-3.jpg" media="(min-width: 320px)"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/highlights-slider-lg-3-1.jpg" alt="highlights-slider-lg-3"> <div class="img-loader"></div> </picture> </div> </div> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <div class="text-wrapper"> <h3>Constantly innovating the HPAPI market.</h3> <p class="text">Recently, Indena successfully developed the manufacturing process of a non-opiate, naturally derived NCE for the treatment of severe pain, establishing and consolidating at the same time the supply chain of a unique biomass. 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