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induced Fanconi syndrome subsection</span> </button> <ul id="toc-Antiviral_induced_Fanconi_syndrome-sublist" class="vector-toc-list"> <li id="toc-Mitochondrial_inhibition" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mitochondrial_inhibition"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Mitochondrial inhibition</span> </div> </a> <ul id="toc-Mitochondrial_inhibition-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span 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data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"><span class="mw-redirectedfrom">(Redirected from <a href="/w/index.php?title=SLC22A6&redirect=no" class="mw-redirect" title="SLC22A6">SLC22A6</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Polytopic_membrane_protein.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/db/Polytopic_membrane_protein.png/400px-Polytopic_membrane_protein.png" decoding="async" width="400" height="257" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/d/db/Polytopic_membrane_protein.png 1.5x" data-file-width="501" data-file-height="322" /></a><figcaption><b>Figure 1</b> <br /> Schematic representation of transmembrane proteins: <br /> 1. a membrane protein with one transmembrane domain <br /> 2. a membrane protein with three transmembrane domains <br /> 3. OAT1 is believed to have twelve transmembrane domains.<sup id="cite_ref-pmid10954321_1-0" class="reference"><a href="#cite_note-pmid10954321-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> <br /> The membrane is represented in light brown.</figcaption></figure> <p>The <b>organic anion transporter 1</b> (OAT1) also known as <b><a href="/wiki/Solute_carrier_family" title="Solute carrier family">solute carrier family</a> 22 member 6</b> (SLC22A6) is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>SLC22A6</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid9762842_2-0" class="reference"><a href="#cite_note-pmid9762842-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9950961_3-0" class="reference"><a href="#cite_note-pmid9950961-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_4-0" class="reference"><a href="#cite_note-entrez-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> It is a member of the <a href="/wiki/Organic_anion_transporter#Organic_anion_transporter_(OAT)_family" class="mw-redirect" title="Organic anion transporter">organic anion transporter</a> (OAT) family of proteins. OAT1 is a <a href="/wiki/Transmembrane_protein" title="Transmembrane protein">transmembrane protein</a> that is expressed in the brain, the placenta, the eyes, <a href="/wiki/Smooth_muscles" class="mw-redirect" title="Smooth muscles">smooth muscles</a>, and the <a href="/wiki/Epithelial_polarity#Basolateral_membranes" title="Epithelial polarity">basolateral membrane</a> of <a href="/wiki/Proximal_convoluted_tubule" class="mw-redirect" title="Proximal convoluted tubule">proximal tubular</a> cells of the kidneys. It plays a central role in <a href="/wiki/Renal" class="mw-redirect" title="Renal">renal</a> <a href="/wiki/Organic_anion" class="mw-redirect" title="Organic anion">organic anion</a> transport. Along with <a href="/wiki/SLC22A8" title="SLC22A8">OAT3</a>, OAT1 mediates the uptake of a wide range of relatively small and <a href="/wiki/Hydrophilic" class="mw-redirect" title="Hydrophilic">hydrophilic</a> organic anions from <a href="/wiki/Blood_plasma" title="Blood plasma">plasma</a> into the <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasm</a> of the proximal tubular cells of the <a href="/wiki/Kidneys" class="mw-redirect" title="Kidneys">kidneys</a>. From there, these substrates are transported into the <a href="/wiki/Lumen_(anatomy)" title="Lumen (anatomy)">lumen</a> of the <a href="/wiki/Nephrons" class="mw-redirect" title="Nephrons">nephrons</a> of the kidneys for <a href="/wiki/Excretion" title="Excretion">excretion</a>. OAT1 <a href="/wiki/Homology_(biology)#Homology_of_sequences_in_genetics" title="Homology (biology)">homologs</a> have been identified in <a href="/wiki/Rat" title="Rat">rats</a>, <a href="/wiki/Mice" class="mw-redirect" title="Mice">mice</a>, <a href="/wiki/Rabbits" class="mw-redirect" title="Rabbits">rabbits</a>, <a href="/wiki/Pig" title="Pig">pigs</a>, <a href="/wiki/Flounder" title="Flounder">flounders</a>, and <a href="/wiki/Caenorhabditis_elegans" title="Caenorhabditis elegans">nematodes</a>.<sup id="cite_ref-pmid16403838_5-0" class="reference"><a href="#cite_note-pmid16403838-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Organic_anion_transporter_1&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">SLC22A6</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/10970">SLC22A6</a></span>, HOAT1, OAT1, PAHT, ROAT1, Organic anion transporter 1, solute carrier family 22 member 6</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/607582">607582</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:892001">892001</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=16813">16813</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC22A6">SLC22A6</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000197901">SLC22A6 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (human)"><img alt="Chromosome 11 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/300px-Ideogram_human_chromosome_11.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/450px-Ideogram_human_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/600px-Ideogram_human_chromosome_11.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_11_(human)" class="mw-redirect" title="Chromosome 11 (human)">Chromosome 11 (human)</a><sup id="cite_ref-refGRCh38Ensembl_6-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_11_ideogram.svg" class="mw-file-description" title="Chromosome 11 (human)"><img alt="Chromosome 11 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/300px-Human_chromosome_11_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/450px-Human_chromosome_11_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/600px-Human_chromosome_11_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 131.68852017962px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SLC22A6"><img alt="Genomic location for SLC22A6" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 137.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SLC22A6"><img alt="Genomic location for SLC22A6" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">11q12.3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">62,936,385 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_6-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">62,984,967 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_6-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/260px-Ideogram_house_mouse_chromosome_19.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/390px-Ideogram_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/520px-Ideogram_house_mouse_chromosome_19.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 19 (mouse)<sup id="cite_ref-refGRCm38Ensembl_7-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/300px-Ideogram_of_house_mouse_chromosome_19.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/450px-Ideogram_of_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/600px-Ideogram_of_house_mouse_chromosome_19.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 35.779192680773px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SLC22A6"><img alt="Genomic location for SLC22A6" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 41.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SLC22A6"><img alt="Genomic location for SLC22A6" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">19 A|19 5.44 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">8,595,403 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_7-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">8,605,663 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_7-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000197901">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">kidney tubule</li><br /><li style="line-height: 137%;">glomerulus</li><br /><li style="line-height: 137%;">metanephric glomerulus</li><br /><li style="line-height: 137%;">renal medulla</li><br /><li style="line-height: 137%;">human kidney</li><br /><li style="line-height: 137%;">buccal mucosa cell</li><br /><li style="line-height: 137%;">retinal pigment epithelium</li><br /><li style="line-height: 137%;">substantia nigra</li><br /><li style="line-height: 137%;">hypothalamus</li><br /><li style="line-height: 137%;">trigeminal ganglion</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000024650">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right kidney</li><br /><li style="line-height: 137%;">human kidney</li><br /><li style="line-height: 137%;">proximal tubule</li><br /><li style="line-height: 137%;">convoluted tubule</li><br /><li style="line-height: 137%;">proximal convoluted tubule</li><br /><li style="line-height: 137%;">optic nerve</li><br /><li style="line-height: 137%;">Meckel's cartilage</li><br /><li style="line-height: 137%;">inner renal medulla</li><br /><li style="line-height: 137%;">yolk sac</li><br /><li style="line-height: 137%;">embryo</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000197901">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_SLC22A6_216599_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PBB_GE_SLC22A6_216599_x_at_fs.png/250px-PBB_GE_SLC22A6_216599_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PBB_GE_SLC22A6_216599_x_at_fs.png/375px-PBB_GE_SLC22A6_216599_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PBB_GE_SLC22A6_216599_x_at_fs.png/500px-PBB_GE_SLC22A6_216599_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_SLC22A6_210343_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PBB_GE_SLC22A6_210343_s_at_fs.png/250px-PBB_GE_SLC22A6_210343_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PBB_GE_SLC22A6_210343_s_at_fs.png/375px-PBB_GE_SLC22A6_210343_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PBB_GE_SLC22A6_210343_s_at_fs.png/500px-PBB_GE_SLC22A6_210343_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/9356/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0022857">transmembrane transporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005452">inorganic anion exchanger activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031404">chloride ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008514">organic anion transmembrane transporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015143">urate transmembrane transporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015347">sodium-independent organic anion transmembrane transporter activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016323">basolateral plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005901">caveola</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031427">response to methotrexate</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097254">renal tubular secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006820">anion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015742">alpha-ketoglutarate transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015711">organic anion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051260">protein homooligomerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098656">anion transmembrane transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015698">inorganic anion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0055085">transmembrane transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015747">urate transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043252">sodium-independent organic anion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903825">organic acid transmembrane transport</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=9356&rn=1">9356</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=18399&rn=1">18399</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000197901;db=core">ENSG00000197901</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000024650;db=core">ENSMUSG00000024650</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q4U2R8">Q4U2R8</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q8VC69">Q8VC69</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_153279">NM_153279</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004790">NM_004790</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_153276">NM_153276</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_153277">NM_153277</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_153278">NM_153278</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008766">NM_008766</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004781">NP_004781</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_695008">NP_695008</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_695009">NP_695009</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_695010">NP_695010</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032792">NP_032792</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr11:62936385-62984967">Chr 11: 62.94 – 62.98 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr19:8595403-8605663">Chr 19: 8.6 – 8.61 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18034026" class="extiw" title="d:Q18034026">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18252844" class="extiw" title="d:Q18252844">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p>OAT1 functions as <a href="/wiki/Organic_anion" class="mw-redirect" title="Organic anion">organic anion</a> exchanger. When the uptake of one molecule of an organic anion is transported into a cell by an OAT1 exchanger, one molecule of an <a href="/wiki/Endogenous" class="mw-redirect" title="Endogenous">endogenous</a> <a href="/wiki/Dicarboxylic_acid" title="Dicarboxylic acid">dicarboxylic acid</a> (such as <a href="/wiki/Glutarate" class="mw-redirect" title="Glutarate">glutarate</a>, <a href="/wiki/Ketoglutarate" class="mw-redirect" title="Ketoglutarate">ketoglutarate</a>, etc.) is simultaneously transported out of the cell.<sup id="cite_ref-pmid16403838_5-1" class="reference"><a href="#cite_note-pmid16403838-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> As a result of the constant removal of endogenous dicarboxylic acid, OAT1-positive cells are at risk of depleting their supply of dicarboxylates. Once the supply of dicarboxylates is depleted, the OAT1 transporter can no longer function. </p><p>To prevent the loss of endogenous dicarboxylates, OAT1-positive cells also express a sodium-dicarboxylate cotransporter called <a href="/wiki/SLC13A3" title="SLC13A3">NaDC3</a> that transports dicarboxylates back into the OAT1-positive cell. Sodium is required to drive this process. In the absence of a sodium gradient across the cell membrane, the NaDC3 cotransporter ceases to function, intra-cellular dicarboxylates are depleted, and the OAT1 transporter also grinds to a halt.<sup id="cite_ref-pmid17356845_10-0" class="reference"><a href="#cite_note-pmid17356845-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The renal organic anion transporters OAT1, <a href="/wiki/SLC22A8" title="SLC22A8">OAT3</a>, <a href="/wiki/OATP4C1" class="mw-redirect" title="OATP4C1">OATP4C1</a>, <a href="/wiki/MDR1" class="mw-redirect" title="MDR1">MDR1</a>, <a href="/wiki/ABCC2" class="mw-redirect" title="ABCC2">MRP2</a>, MRP4 and URAT1 are expressed in the <a href="/wiki/Proximal_convoluted_tubules#Divisions" class="mw-redirect" title="Proximal convoluted tubules">S2 segment</a> of the proximal convoluted tubules of the kidneys. OAT1, OAT3, and OATP4C1 transport small organic anions from the plasma into the S2 cells. MDR1, MRP2, MRP4 and URAT1 then transports these organic anions from the cytoplasm of the S2 cells into the lumen of the proximal convoluted tubules. These organic anions are then excreted in the urine.<sup id="cite_ref-pmid16403838_5-2" class="reference"><a href="#cite_note-pmid16403838-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Substrates">Substrates</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Organic_anion_transporter_1&action=edit&section=2" title="Edit section: Substrates"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Known <a href="/wiki/Substrate_(biochemistry)" class="mw-redirect" title="Substrate (biochemistry)">substrates</a> of OAT1 include <a href="/wiki/Para-aminohippurate" class="mw-redirect" title="Para-aminohippurate">para-aminohippurate</a> (PAH), <a href="/wiki/Dicarboxylic_acid" title="Dicarboxylic acid">dicarboxylates</a>, <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandins</a>, <a href="/wiki/Cyclic_nucleotide" title="Cyclic nucleotide">cyclic nucleotides</a>, <a href="/wiki/Urate" class="mw-redirect" title="Urate">urate</a>, <a href="/wiki/Folate" title="Folate">folate</a>, <a href="/wiki/Diuretic" title="Diuretic">diuretics</a>, <a href="/wiki/ACE_inhibitor" title="ACE inhibitor">ACE inhibitors</a>, <a href="/wiki/Antiviral_drug" title="Antiviral drug">antiviral</a> agents, <a href="/wiki/Beta-lactam_antibiotic" class="mw-redirect" title="Beta-lactam antibiotic">beta-lactam antibiotics</a>, <a href="/wiki/Antineoplastic" class="mw-redirect" title="Antineoplastic">antineoplastics</a>, <a href="/wiki/Mycotoxin" title="Mycotoxin">mycotoxins</a>, <a href="/wiki/Sulfate_conjugate" title="Sulfate conjugate">sulfate conjugates</a>, <a href="/wiki/Glucuronide" title="Glucuronide">glucuronide</a> conjugates, <a href="/wiki/Cysteine" title="Cysteine">cysteine</a> conjugates, <a href="/wiki/Ochratoxin_A" title="Ochratoxin A">ochratoxin A</a>, <a href="/wiki/NSAIDs" class="mw-redirect" title="NSAIDs">NSAIDs</a>, <a href="/w/index.php?title=Mercapturic_acids&action=edit&redlink=1" class="new" title="Mercapturic acids (page does not exist)">mercapturic acids</a> and <a href="/wiki/Uremic_toxin" class="mw-redirect" title="Uremic toxin">uremic toxins</a>.<sup id="cite_ref-pmid16403838_5-3" class="reference"><a href="#cite_note-pmid16403838-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Regulation">Regulation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Organic_anion_transporter_1&action=edit&section=3" title="Edit section: Regulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Alterations in the expression and function of OAT1 play important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OAT1 must be under tight regulation so as to carry out their normal functions.<sup id="cite_ref-pmid27291023_11-0" class="reference"><a href="#cite_note-pmid27291023-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The regulation of OAT transport activity in response to various stimuli can occur at several levels such as transcription, translation, and posttranslational modification. Posttranslational regulation is of particular interest, because it usually happens within a very short period of time (minutes to hours) when the body has to deal with rapidly changing amounts of substances as a consequence of variable intake of drugs, fluids, or meals as well as metabolic activity.<sup id="cite_ref-pmid27291023_11-1" class="reference"><a href="#cite_note-pmid27291023-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Post-translational modification is a process where new functional group(s) are conjugated to the amino acid side chains in a target protein through reversible or irreversible biochemical reactions. The common modifications include glycosylation, phosphorylation, ubiquitination,<sup id="cite_ref-pmid27291023_11-2" class="reference"><a href="#cite_note-pmid27291023-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> sulfation, methylation, acetylation, and hydroxylation. </p> <div class="mw-heading mw-heading2"><h2 id="Antiviral_induced_Fanconi_syndrome">Antiviral induced Fanconi syndrome</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Organic_anion_transporter_1&action=edit&section=4" title="Edit section: Antiviral induced Fanconi syndrome"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nucleoside analogs are a class of antiviral drugs that work by inhibiting viral nucleic acid synthesis. The nucleoside analogs <a href="/wiki/Acyclovir" class="mw-redirect" title="Acyclovir">acyclovir</a> (ACV), <a href="/wiki/Zidovudine" title="Zidovudine">zidovudine</a> (AZT), <a href="/wiki/Didanosine" title="Didanosine">didanosine</a> (ddI), <a href="/wiki/Zalcitabine" title="Zalcitabine">zalcitabine</a> (ddC), <a href="/wiki/Lamivudine" title="Lamivudine">lamivudine</a> (3TC), <a href="/wiki/Stavudine" title="Stavudine">stavudine</a> (d4T), <a href="/wiki/Trifluridine" title="Trifluridine">trifluridine</a>,<sup id="cite_ref-pmid10945832_12-0" class="reference"><a href="#cite_note-pmid10945832-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Cidofovir" title="Cidofovir">cidofovir</a>, <a href="/wiki/Adefovir" title="Adefovir">adefovir</a>,<sup id="cite_ref-pmid10703662_13-0" class="reference"><a href="#cite_note-pmid10703662-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">tenofovir</a> (TDF) <sup id="cite_ref-Kohler_2010_14-0" class="reference"><a href="#cite_note-Kohler_2010-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> are substrates of the OAT1 transporter. This may result in the buildup of these drugs in the <a href="/wiki/Proximal_tubule" title="Proximal tubule">proximal tubule</a> cells. At high concentrations, these drugs inhibit <a href="/wiki/DNA_replication" title="DNA replication">DNA replication</a>. This, in turn, may impair the function of these cells and may be the cause of antiviral induced <a href="/wiki/Fanconi_syndrome" title="Fanconi syndrome">Fanconi syndrome</a>. The use of stavudine,<sup id="cite_ref-pmid18580619_15-0" class="reference"><a href="#cite_note-pmid18580619-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> didenosine, abacavir, adefovir,<sup id="cite_ref-pmid17102551_16-0" class="reference"><a href="#cite_note-pmid17102551-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> cidofovir <sup id="cite_ref-pmid9257778_17-0" class="reference"><a href="#cite_note-pmid9257778-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> and tenofovir has been associated with Fanconi syndrome. Clinical features of tenofovir-induced Fanconi syndrome include glycosuria in the setting of normal serum glucose levels, phosphate wasting with hypophosphatemia, proteinuria (usually mild), acidosis, and hypokalemia, with or without acute renal failure.<sup id="cite_ref-pmid19334329_18-0" class="reference"><a href="#cite_note-pmid19334329-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Mitochondrial_inhibition">Mitochondrial inhibition</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Organic_anion_transporter_1&action=edit&section=5" title="Edit section: Mitochondrial inhibition"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Since <a href="/wiki/Reverse_transcriptase_inhibitor#Nucleoside_analog_reverse_transcriptase_inhibitors_(NARTIs_or_NRTIs)" class="mw-redirect" title="Reverse transcriptase inhibitor">nucleoside analogs</a> can build up in OAT1-positive cells and can inhibit <a href="/wiki/Mitochondrial" class="mw-redirect" title="Mitochondrial">mitochondrial</a> replication, these drugs may lead to the depletion of mitochondria inside renal <a href="/wiki/Proximal_convoluted_tubule" class="mw-redirect" title="Proximal convoluted tubule">proximal tubules</a>. Renal <a href="/wiki/Biopsies" class="mw-redirect" title="Biopsies">biopsies</a> have demonstrated the depletion of tubule cell mitochondria among individuals receiving antiviral therapy with tenofovir. The remaining mitochondria were enlarged and <a href="/wiki/Dysmorphic_feature" title="Dysmorphic feature">dysmorphic</a>.<sup id="cite_ref-pmid20811330_19-0" class="reference"><a href="#cite_note-pmid20811330-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> <i><a href="/wiki/In_vitro" title="In vitro">In vitro</a></i> the antiviral drugs didanosine and zidovudine are more potent inhibitors of <a href="/wiki/Mitochondrial_DNA" title="Mitochondrial DNA">mitochondrial DNA</a> synthesis than tenofovir (ddI > AZT > TDF).<sup id="cite_ref-pmid16940060_20-0" class="reference"><a href="#cite_note-pmid16940060-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> In its non-phosphorylated form, the drug acyclovir does not significantly inhibit mitochondrial DNA synthesis, unless the cell happens to be infected with a <a href="/wiki/Herpesviridae" title="Herpesviridae">herpes virus</a>. <sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (March 2015)">citation needed</span></a></i>]</sup> </p><p>Stavudine, zidovudine and <a href="/wiki/Indinavir" title="Indinavir">indinavir</a> (IDV) cause a decrease in mitochondrial <a href="/wiki/Cellular_respiration" title="Cellular respiration">respiration</a> and an increase in mitochondrial mass in <a href="/wiki/Fat_cells" class="mw-redirect" title="Fat cells">fat cells</a>. Stavudine also causes severe mitochondrial DNA depletion. Combining zidovudine with stavudine does not increase the mitochondrial toxicity compared to stavudine alone. Both of these drugs must be <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylated</a> by host enzymes before they become active. Zidovudine inhibits the phosphorylation of stavudine. This might reduce the toxicity of the combination. Using indinavir in combination with the other two drugs did not increase the toxicity of the combination. Indinavir is a <a href="/wiki/Protease_inhibitor_(pharmacology)" title="Protease inhibitor (pharmacology)">protease inhibitor</a> and works by a different mechanism than the other antiviral drugs. (d4T+AZT+IDV = d4T+AZT = d4T+IDV > AZT+IDV = AZT = IDV). All three of these drugs inhibit the expression of respiratory chain subunits (cytochrome c oxidase [CytOx]2 and CytOx4) in white fat cells but not <a href="/wiki/Brown_fat" class="mw-redirect" title="Brown fat">brown fat</a> cells.<sup id="cite_ref-pmid17926646_21-0" class="reference"><a href="#cite_note-pmid17926646-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Since stavudine and zidovudine are OAT1 substrates, they may have similar effects on proximal renal tubule cells as they do on fat cells. </p><p>Lamivudine has reverse <a href="/wiki/Chirality_(chemistry)" title="Chirality (chemistry)">chirality</a> compared to didanosine, stavudine, zidovudine, and natural <a href="/wiki/Nucleosides" class="mw-redirect" title="Nucleosides">nucleosides</a>. Mitochondrial <a href="/wiki/DNA_polymerase" title="DNA polymerase">DNA polymerase</a> may not recognize it as a substrate. Lamivudine is not toxic to mitochondria <i><a href="/wiki/In_vivo" title="In vivo">in vivo</a></i>.<sup id="cite_ref-pmid9214472_22-0" class="reference"><a href="#cite_note-pmid9214472-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> Individuals who had been taking didanosine combined with stavudine exhibited improved mitochondrial function when they switched to lamivudine combined with tenofovir.<sup id="cite_ref-pmid9214472_22-1" class="reference"><a href="#cite_note-pmid9214472-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid18339636_23-0" class="reference"><a href="#cite_note-pmid18339636-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>Mitochondrial toxicity of OAT1 substrates: </p> <ul><li><i>in vitro</i>: <ul><li>d4T+AZT = d4T > AZT</li> <li>ddI > AZT > TDF > ACV</li></ul></li> <li><i>in vivo</i> <ul><li>d4T > AZT</li> <li>ddI > AZT > TDF</li> <li>d4T + ddI > 3TC + TDF</li></ul></li></ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Organic_anion_transporter_1&action=edit&section=6" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Solute_carrier_family" title="Solute carrier family">Solute carrier family</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Organic_anion_transporter_1&action=edit&section=7" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-pmid10954321-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10954321_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px 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"Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney". <i>Am. J. Physiol</i>. <b>276</b> (1 Pt 2): F122–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1152%2Fajprenal.1999.276.1.F122">10.1152/ajprenal.1999.276.1.F122</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9887087">9887087</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Physiol.&rft.atitle=Molecular+cloning+and+functional+expression+of+a+multispecific+organic+anion+transporter+from+human+kidney&rft.volume=276&rft.issue=1+Pt+2&rft.pages=F122-8&rft.date=1999&rft_id=info%3Adoi%2F10.1152%2Fajprenal.1999.276.1.F122&rft_id=info%3Apmid%2F9887087&rft.aulast=Hosoyamada&rft.aufirst=M&rft.au=Sekine%2C+T&rft.au=Kanai%2C+Y&rft.au=Endou%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3AOrganic+anion+transporter+1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRaceGrasslWilliamsHoltzman1999" class="citation journal cs1">Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Solute_carrier_family" title="Template:Solute carrier family"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Solute_carrier_family" title="Template talk:Solute carrier family"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Solute_carrier_family" title="Special:EditPage/Template:Solute carrier family"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Membrane_proteins,_carrier_proteins:_membrane_transport_proteins_solute_carrier_(TC_2A)" style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_protein" title="Membrane protein">Membrane proteins</a>, <a href="/wiki/Carrier_protein" class="mw-redirect" title="Carrier protein">carrier proteins</a>: <a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">membrane transport proteins</a> <a href="/wiki/Solute_carrier_family" title="Solute carrier family">solute carrier</a> (<a href="/wiki/Transporter_Classification_Database#2.A.09Porters_(uniporters,_symporters,_antiporters)" title="Transporter Classification Database">TC 2A</a>)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="By_group" style="font-size:114%;margin:0 4em">By group</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC1–10" style="font-size:114%;margin:0 4em">SLC1–10</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(1):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Excitatory_amino-acid_transporter" class="mw-redirect" title="Excitatory amino-acid transporter">high affinity glutamate and neutral amino-acid transporter</a> <ul><li><a href="/wiki/SLC1A1" class="mw-redirect" title="SLC1A1">SLC1A1</a></li> <li><a href="/wiki/SLC1A2" class="mw-redirect" title="SLC1A2">2</a></li> <li><a href="/wiki/Glutamate_aspartate_transporter" class="mw-redirect" title="Glutamate aspartate transporter">3</a></li> <li><a href="/wiki/SLC1A4" class="mw-redirect" title="SLC1A4">4</a></li> <li><a href="/wiki/SLC1A5" class="mw-redirect" title="SLC1A5">5</a></li> <li><a href="/wiki/Excitatory_amino-acid_transporter_4" class="mw-redirect" title="Excitatory amino-acid transporter 4">6</a></li> <li><a href="/wiki/Excitatory_amino-acid_transporter_5" class="mw-redirect" title="Excitatory amino-acid transporter 5">7</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(2):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glucose_transporter" title="Glucose transporter">facilitative GLUT transporter</a> <ul><li><a href="/wiki/GLUT1" title="GLUT1">SLC2A1</a></li> <li><a href="/wiki/GLUT2" title="GLUT2">2</a></li> <li><a href="/wiki/GLUT3" title="GLUT3">3</a></li> <li><a href="/wiki/GLUT4" title="GLUT4">4</a></li> <li><a href="/wiki/GLUT5" title="GLUT5">5</a></li> <li><a href="/wiki/SLC2A6" title="SLC2A6">6</a></li> <li><a href="/wiki/SLC2A7" title="SLC2A7">7</a></li> <li><a href="/wiki/GLUT8" title="GLUT8">8</a></li> <li><a href="/wiki/SLC2A9" title="SLC2A9">9</a></li> <li><a href="/wiki/SLC2A10" title="SLC2A10">10</a></li> <li><a href="/wiki/SLC2A11" title="SLC2A11">11</a></li> <li><a href="/wiki/SLC2A12" title="SLC2A12">12</a></li> <li><a href="/wiki/SLC2A13" title="SLC2A13">13</a></li> <li><a href="/wiki/SLC2A14" title="SLC2A14">14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(3):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>heavy subunits of <a href="/wiki/Heterodimeric_amino-acid_transporter" title="Heterodimeric amino-acid transporter">heterodimeric amino-acid transporters</a> <ul><li><a href="/wiki/SLC3A1" class="mw-redirect" title="SLC3A1">SLC3A1</a></li> <li><a href="/wiki/SLC3A2" class="mw-redirect" title="SLC3A2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(4):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bicarbonate_transporter_protein" class="mw-redirect" title="Bicarbonate transporter protein">bicarbonate transporter</a> <ul><li><a href="/wiki/Band_3" class="mw-redirect" title="Band 3">SLC4A1</a></li> <li><a href="/wiki/SLC4A2" class="mw-redirect" title="SLC4A2">2</a></li> <li><a href="/wiki/SLC4A3" class="mw-redirect" title="SLC4A3">3</a></li> <li><a href="/wiki/SLC4A4" class="mw-redirect" title="SLC4A4">4</a></li> <li><a href="/wiki/SLC4A5" class="mw-redirect" title="SLC4A5">5</a></li> <li><a href="/wiki/SLC4A6" class="mw-redirect" title="SLC4A6">6</a></li> <li><a href="/wiki/SLC4A7" class="mw-redirect" title="SLC4A7">7</a></li> <li><a href="/wiki/SLC4A8" class="mw-redirect" title="SLC4A8">8</a></li> <li><a href="/w/index.php?title=SLC4A9&action=edit&redlink=1" class="new" title="SLC4A9 (page does not exist)">9</a></li> <li><a href="/w/index.php?title=SLC4A10&action=edit&redlink=1" class="new" title="SLC4A10 (page does not exist)">10</a></li> <li><a href="/wiki/SLC4A11" class="mw-redirect" title="SLC4A11">11</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(5):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium-glucose_transport_proteins" title="Sodium-glucose transport proteins">sodium glucose cotransporter</a> <ul><li><a href="/wiki/SLC5A1" class="mw-redirect" title="SLC5A1">SLC5A1</a></li> <li><a href="/wiki/SGLT2" class="mw-redirect" title="SGLT2">2</a></li> <li><a href="/wiki/SLC5A3" class="mw-redirect" title="SLC5A3">3</a></li> <li><a href="/wiki/SLC5A4" title="SLC5A4">4</a></li> <li><a href="/wiki/Sodium-iodide_symporter" class="mw-redirect" title="Sodium-iodide symporter">5</a></li> <li><a href="/wiki/SLC5A6" class="mw-redirect" title="SLC5A6">6</a></li> <li><a href="/wiki/Choline_transporter" title="Choline transporter">7</a></li> <li><a href="/wiki/SLC5A8" class="mw-redirect" title="SLC5A8">8</a></li> <li><a href="/w/index.php?title=SLC5A9&action=edit&redlink=1" class="new" title="SLC5A9 (page does not exist)">9</a></li> <li><a href="/w/index.php?title=SLC5A10&action=edit&redlink=1" class="new" title="SLC5A10 (page does not exist)">10</a></li> <li><a href="/w/index.php?title=SLC5A11&action=edit&redlink=1" class="new" title="SLC5A11 (page does not exist)">11</a></li> <li><a href="/w/index.php?title=SLC5A12&action=edit&redlink=1" class="new" title="SLC5A12 (page does not exist)">12</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(6):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium" title="Sodium">sodium</a>- and <a href="/wiki/Chloride" title="Chloride">chloride</a>- dependent <a href="/wiki/Sodium:neurotransmitter_symporter" class="mw-redirect" title="Sodium:neurotransmitter symporter">sodium:neurotransmitter symporters</a> <ul><li><a href="/wiki/GABA_transporter_1" class="mw-redirect" title="GABA transporter 1">SLC6A1</a></li> <li><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">SLC6A2</a></li> <li><a href="/wiki/Dopamine_transporter" title="Dopamine transporter">SLC6A3</a></li> <li><a href="/wiki/Serotonin_transporter" title="Serotonin transporter">SLC6A4</a></li> <li><a href="/wiki/SLC6A5" class="mw-redirect" title="SLC6A5">SLC6A5</a></li> <li><a href="/wiki/SLC6A6" class="mw-redirect" title="SLC6A6">SLC6A6</a></li> <li><a href="/w/index.php?title=SLC6A7&action=edit&redlink=1" class="new" title="SLC6A7 (page does not exist)">SLC6A7</a></li> <li><a href="/wiki/SLC6A8" class="mw-redirect" title="SLC6A8">SLC6A8</a></li> <li><a href="/wiki/SLC6A9" class="mw-redirect" title="SLC6A9">SLC6A9</a></li> <li><a href="/w/index.php?title=SLC6A10&action=edit&redlink=1" class="new" title="SLC6A10 (page does not exist)">SLC6A10</a></li> <li><a href="/wiki/SLC6A11" class="mw-redirect" title="SLC6A11">SLC6A11</a></li> <li><a href="/wiki/SLC6A12" class="mw-redirect" title="SLC6A12">SLC6A12</a></li> <li><a href="/wiki/SLC6A13" class="mw-redirect" title="SLC6A13">SLC6A13</a></li> <li><a href="/wiki/SLC6A14" title="SLC6A14">SLC6A14</a></li> <li><a href="/wiki/SLC6A15" class="mw-redirect" title="SLC6A15">SLC6A15</a></li> <li><a href="/w/index.php?title=SLC6A16&action=edit&redlink=1" class="new" title="SLC6A16 (page does not exist)">SLC6A16</a></li> <li><a href="/w/index.php?title=SLC6A17&action=edit&redlink=1" class="new" title="SLC6A17 (page does not exist)">SLC6A17</a></li> <li><a href="/wiki/SLC6A18" title="SLC6A18">SLC6A18</a></li> <li><a href="/wiki/SLC6A19" class="mw-redirect" title="SLC6A19">SLC6A19</a></li> <li><a href="/wiki/SLC6A20" title="SLC6A20">SLC6A20</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(7):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>cationic amino-acid transporter/glycoprotein-associated <ul><li><a href="/wiki/SLC7A1" class="mw-redirect" title="SLC7A1">SLC7A1</a></li> <li><a href="/wiki/SLC7A2" class="mw-redirect" title="SLC7A2">SLC7A2</a></li> <li><a href="/wiki/SLC7A3" class="mw-redirect" title="SLC7A3">SLC7A3</a></li> <li><a href="/wiki/SLC7A4" class="mw-redirect" title="SLC7A4">SLC7A4</a></li></ul></li> <li>glycoprotein-associated/light or catalytic subunits of <a href="/wiki/Heterodimeric_amino-acid_transporter" title="Heterodimeric amino-acid transporter">heterodimeric amino-acid transporters</a> <ul><li><a href="/wiki/CD98" title="CD98">SLC7A5</a></li> <li><a href="/wiki/SLC7A6" class="mw-redirect" title="SLC7A6">SLC7A6</a></li> <li><a href="/wiki/SLC7A7" class="mw-redirect" title="SLC7A7">SLC7A7</a></li> <li><a href="/wiki/SLC7A8" class="mw-redirect" title="SLC7A8">SLC7A8</a></li> <li><a href="/wiki/SLC7A9" class="mw-redirect" title="SLC7A9">SLC7A9</a></li> <li><a href="/wiki/SLC7A10" class="mw-redirect" title="SLC7A10">SLC7A10</a></li> <li><a href="/wiki/SLC7A11" class="mw-redirect" title="SLC7A11">SLC7A11</a></li> <li><a href="/w/index.php?title=SLC7A13&action=edit&redlink=1" class="new" title="SLC7A13 (page does not exist)">SLC7A13</a></li> <li><a href="/wiki/SLC7A14" title="SLC7A14">SLC7A14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(8):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Na<sup>+</sup>/Ca<sup>2+</sup> exchanger</a> <ul><li><a href="/wiki/SLC8A1" class="mw-redirect" title="SLC8A1">SLC8A1</a></li> <li><a href="/w/index.php?title=SLC8A2&action=edit&redlink=1" class="new" title="SLC8A2 (page does not exist)">SLC8A2</a></li> <li><a href="/w/index.php?title=SLC8A3&action=edit&redlink=1" class="new" title="SLC8A3 (page does not exist)">SLC8A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(9):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium%E2%80%93hydrogen_antiporter" title="Sodium–hydrogen antiporter">Na<sup>+</sup>/H<sup>+</sup> exchanger</a> <ul><li><a href="/wiki/SLC9A1" class="mw-redirect" title="SLC9A1">SLC9A1</a></li> <li><a href="/wiki/SLC9A2" class="mw-redirect" title="SLC9A2">SLC9A2</a></li> <li><a href="/wiki/SLC9A3" class="mw-redirect" title="SLC9A3">SLC9A3</a></li> <li><a href="/w/index.php?title=SLC9A4&action=edit&redlink=1" class="new" title="SLC9A4 (page does not exist)">SLC9A4</a></li> <li><a href="/wiki/SLC9A5" class="mw-redirect" title="SLC9A5">SLC9A5</a></li> <li><a href="/wiki/SLC9A6" class="mw-redirect" title="SLC9A6">SLC9A6</a></li> <li><a href="/w/index.php?title=SLC9A7&action=edit&redlink=1" class="new" title="SLC9A7 (page does not exist)">SLC9A7</a></li> <li><a href="/wiki/SLC9A8" class="mw-redirect" title="SLC9A8">SLC9A8</a></li> <li><a href="/w/index.php?title=SLC9A9&action=edit&redlink=1" class="new" title="SLC9A9 (page does not exist)">SLC9A9</a></li> <li><a href="/wiki/SLC9A10" class="mw-redirect" title="SLC9A10">SLC9A10</a></li> <li><a href="/wiki/SLC9A11" class="mw-redirect" title="SLC9A11">SLC9A11</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(10):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Sodium_bile_salt_cotransport&action=edit&redlink=1" class="new" title="Sodium bile salt cotransport (page does not exist)">sodium bile salt cotransport</a> <ul><li><a href="/wiki/SLC10A1" class="mw-redirect" title="SLC10A1">SLC10A1</a></li> <li><a href="/wiki/SLC10A2" class="mw-redirect" title="SLC10A2">SLC10A2</a></li> <li><a href="/wiki/SLC10A3" class="mw-redirect" title="SLC10A3">SLC10A3</a></li> <li><a href="/w/index.php?title=SLC10A4&action=edit&redlink=1" class="new" title="SLC10A4 (page does not exist)">SLC10A4</a></li> <li><a href="/w/index.php?title=SLC10A5&action=edit&redlink=1" class="new" title="SLC10A5 (page does not exist)">SLC10A5</a></li> <li><a href="/w/index.php?title=SLC10A6&action=edit&redlink=1" class="new" title="SLC10A6 (page does not exist)">SLC10A6</a></li> <li><a href="/wiki/SLC10A7" class="mw-redirect" title="SLC10A7">SLC10A7</a></li></ul></li> <li><a href="/wiki/SLC10A1" class="mw-redirect" title="SLC10A1">10A1</a></li> <li><a href="/wiki/SLC10A2" class="mw-redirect" title="SLC10A2">10A2</a></li> <li><a href="/wiki/SLC10A3" class="mw-redirect" title="SLC10A3">10A3</a></li> <li><a href="/wiki/SLC10A7" class="mw-redirect" title="SLC10A7">10A7</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC11–20" style="font-size:114%;margin:0 4em">SLC11–20</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(11):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Proton_coupled_metal_ion_transporter&action=edit&redlink=1" class="new" title="Proton coupled metal ion transporter (page does not exist)">proton coupled metal ion transporter</a> <ul><li><a href="/wiki/SLC11A1" class="mw-redirect" title="SLC11A1">SLC11A1</a></li> <li><a href="/wiki/SLC11A2" class="mw-redirect" title="SLC11A2">SLC11A2</a><a href="/wiki/Ferroportin" title="Ferroportin">11A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(12):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Electroneutral_cation-Cl" title="Electroneutral cation-Cl">electroneutral cation-Cl</a> cotransporter <ul><li><a href="/wiki/Na-K-Cl_cotransporter" class="mw-redirect" title="Na-K-Cl cotransporter">SLC12A1</a></li> <li><a href="/wiki/Na-K-Cl_cotransporter" class="mw-redirect" title="Na-K-Cl cotransporter">SLC12A2</a></li> <li><a href="/wiki/Sodium-chloride_symporter" title="Sodium-chloride symporter">SLC12A3</a></li> <li><a href="/wiki/Chloride_potassium_symporter_4" title="Chloride potassium symporter 4">SLC12A4</a></li> <li><a href="/wiki/Chloride_potassium_symporter_5" title="Chloride potassium symporter 5">SLC12A5</a></li> <li><a href="/wiki/SLC12A6" title="SLC12A6">SLC12A6</a></li> <li><a href="/wiki/SLC12A7" title="SLC12A7">SLC12A7</a></li> <li><a href="/wiki/SLC12A8" title="SLC12A8">SLC12A8</a></li> <li><a href="/wiki/SLC12A9" title="SLC12A9">SLC12A9</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(13):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Human_Na%2B-sulfate/carboxylate_cotransporter&action=edit&redlink=1" class="new" title="Human Na+-sulfate/carboxylate cotransporter (page does not exist)">human Na<sup>+</sup>-sulfate/carboxylate cotransporter</a> <ul><li><a href="/w/index.php?title=SLC13A1&action=edit&redlink=1" class="new" title="SLC13A1 (page does not exist)">SLC13A1</a></li> <li><a href="/wiki/SLC13A2" title="SLC13A2">SLC13A2</a></li> <li><a href="/wiki/SLC13A3" title="SLC13A3">SLC13A3</a></li> <li><a href="/w/index.php?title=SLC13A4&action=edit&redlink=1" class="new" title="SLC13A4 (page does not exist)">SLC13A4</a></li> <li><a href="/wiki/SLC13A5" title="SLC13A5">SLC13A5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(14):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Urea_transporter" title="Urea transporter">urea transporter</a> <ul><li><a href="/wiki/SLC14A1" class="mw-redirect" title="SLC14A1">SLC14A1</a></li> <li><a href="/wiki/SLC14A2" class="mw-redirect" title="SLC14A2">SLC14A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(15):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Proton_oligopeptide_cotransporter&action=edit&redlink=1" class="new" title="Proton oligopeptide cotransporter (page does not exist)">proton oligopeptide cotransporter</a> <ul><li><a href="/wiki/Peptide_transporter_1" title="Peptide transporter 1">SLC15A1</a></li> <li><a href="/wiki/SLC15A2" title="SLC15A2">SLC15A2</a></li> <li><a href="/w/index.php?title=SLC15A3&action=edit&redlink=1" class="new" title="SLC15A3 (page does not exist)">SLC15A3</a></li> <li><a href="/wiki/SLC15A4" title="SLC15A4">SLC15A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(16):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Monocarboxylate&action=edit&redlink=1" class="new" title="Monocarboxylate (page does not exist)">monocarboxylate</a> transporter <ul><li><a href="/wiki/Monocarboxylate_transporter_1" title="Monocarboxylate transporter 1">SLC16A1</a></li> <li><a href="/wiki/Monocarboxylate_transporter_8" title="Monocarboxylate transporter 8">SLC16A2</a></li> <li><a href="/wiki/Monocarboxylate_transporter_4" title="Monocarboxylate transporter 4">SLC16A3</a></li> <li><a href="/wiki/Monocarboxylate_transporter_5" title="Monocarboxylate transporter 5">SLC16A4</a></li> <li><a href="/wiki/SLC16A5" class="mw-redirect" title="SLC16A5">SLC16A5</a></li> <li><a href="/w/index.php?title=SLC16A6&action=edit&redlink=1" class="new" title="SLC16A6 (page does not exist)">SLC16A6</a></li> <li><a href="/wiki/Monocarboxylate_transporter_2" title="Monocarboxylate transporter 2">SLC16A7</a></li> <li><a href="/wiki/Monocarboxylate_transporter_3" title="Monocarboxylate transporter 3">SLC16A8</a></li> <li><a href="/wiki/Monocarboxylate_transporter_9" title="Monocarboxylate transporter 9">SLC16A9</a></li> <li><a href="/wiki/Monocarboxylate_transporter_10" title="Monocarboxylate transporter 10">SLC16A10</a></li> <li><a href="/wiki/SLC16A11" title="SLC16A11">SLC16A11</a></li> <li><a href="/w/index.php?title=SLC16A12&action=edit&redlink=1" class="new" title="SLC16A12 (page does not exist)">SLC16A12</a></li> <li><a href="/w/index.php?title=SLC16A13&action=edit&redlink=1" class="new" title="SLC16A13 (page does not exist)">SLC16A13</a></li> <li><a href="/w/index.php?title=SLC16A14&action=edit&redlink=1" class="new" title="SLC16A14 (page does not exist)">SLC16A14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(17):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vesicular_glutamate_transporter_1" title="Vesicular glutamate transporter 1">Vesicular glutamate transporter 1</a> <ul><li><a href="/wiki/SLC17A1" class="mw-redirect" title="SLC17A1">SLC17A1</a></li> <li><a href="/w/index.php?title=SLC17A2&action=edit&redlink=1" class="new" title="SLC17A2 (page does not exist)">SLC17A2</a></li> <li><a href="/wiki/SLC17A3" title="SLC17A3">SLC17A3</a></li> <li><a href="/w/index.php?title=SLC17A4&action=edit&redlink=1" class="new" title="SLC17A4 (page does not exist)">SLC17A4</a></li> <li><a href="/wiki/SLC17A5" class="mw-redirect" title="SLC17A5">SLC17A5</a></li> <li><a href="/w/index.php?title=SLC17A6&action=edit&redlink=1" class="new" title="SLC17A6 (page does not exist)">SLC17A6</a></li> <li><a href="/wiki/SLC17A7" class="mw-redirect" title="SLC17A7">SLC17A7</a></li> <li><a href="/wiki/SLC17A8" class="mw-redirect" title="SLC17A8">SLC17A8</a></li> <li><a href="/wiki/SLC17A9" title="SLC17A9">SLC17A9</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(18):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vesicular_monoamine_transporter" title="Vesicular monoamine transporter">vesicular monoamine transporter</a> <ul><li><a href="/wiki/VMAT1" class="mw-redirect" title="VMAT1">SLC18A1</a></li> <li><a href="/wiki/VMAT2" class="mw-redirect" title="VMAT2">SLC18A2</a></li> <li><a href="/wiki/Vesicular_acetylcholine_transporter" title="Vesicular acetylcholine transporter">SLC18A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(19):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Folate" title="Folate">folate</a>/<a href="/wiki/Thiamine" title="Thiamine">thiamine</a> transporter <ul><li><a href="/wiki/SLC19A1" class="mw-redirect" title="SLC19A1">SLC19A1</a></li> <li><a href="/wiki/SLC19A2" class="mw-redirect" title="SLC19A2">SLC19A2</a></li> <li><a href="/wiki/SLC19A3" class="mw-redirect" title="SLC19A3">SLC19A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(20):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Type_III_Na%2B-phosphate" class="mw-redirect" title="Type III Na+-phosphate">type III Na<sup>+</sup>-phosphate</a> cotransporter <ul><li><a href="/wiki/SLC20A1" title="SLC20A1">SLC20A1</a></li> <li><a href="/wiki/SLC20A2" title="SLC20A2">SLC20A2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC21–30" style="font-size:114%;margin:0 4em">SLC21–30</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(21):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Organic_anion-transporting_polypeptide" class="mw-redirect" title="Organic anion-transporting polypeptide">Organic anion-transporting polypeptide</a> <ul><li><a href="/wiki/SLCO1A2" class="mw-redirect" title="SLCO1A2">SLCO1A2</a></li> <li><a href="/wiki/SLCO1B1" class="mw-redirect" title="SLCO1B1">SLCO1B1</a></li> <li><a href="/wiki/SLCO1B3" class="mw-redirect" title="SLCO1B3">SLCO1B3</a></li> <li><a href="/w/index.php?title=SLCO1B4&action=edit&redlink=1" class="new" title="SLCO1B4 (page does not exist)">SLCO1B4</a></li> <li><a href="/wiki/SLCO1C1" class="mw-redirect" title="SLCO1C1">SLCO1C1</a></li></ul></li> <li> <ul><li><a href="/wiki/SLCO2A1" class="mw-redirect" title="SLCO2A1">SLCO2A1</a></li> <li><a href="/wiki/SLCO2B1" class="mw-redirect" title="SLCO2B1">SLCO2B1</a></li></ul></li> <li> <ul><li><a href="/wiki/SLCO3A1" class="mw-redirect" title="SLCO3A1">SLCO3A1</a></li></ul></li> <li> <ul><li><a href="/wiki/SLCO4A1" class="mw-redirect" title="SLCO4A1">SLCO4A1</a></li> <li><a href="/w/index.php?title=SLCO4C1&action=edit&redlink=1" class="new" title="SLCO4C1 (page does not exist)">SLCO4C1</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLCO5A1&action=edit&redlink=1" class="new" title="SLCO5A1 (page does not exist)">SLCO5A1</a>(<a href="/w/index.php?title=SLCO6A1&action=edit&redlink=1" class="new" title="SLCO6A1 (page does not exist)">SLCO6A1</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(22):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Organic_cation/anion/zwitterion_transporter" class="mw-redirect" title="Organic cation/anion/zwitterion transporter">organic cation/anion/zwitterion transporter</a> <ul><li><a href="/wiki/SLC22A1" title="SLC22A1">SLC22A1</a></li> <li><a href="/wiki/SLC22A2" title="SLC22A2">SLC22A2</a></li> <li><a href="/wiki/SLC22A3" title="SLC22A3">SLC22A3</a></li> <li><a href="/wiki/SLC22A4" title="SLC22A4">SLC22A4</a></li> <li><a href="/wiki/SLC22A5" title="SLC22A5">SLC22A5</a></li> <li><a href="/wiki/SLC22A6" class="mw-redirect" title="SLC22A6">SLC22A6</a></li> <li><a href="/wiki/SLC22A7" title="SLC22A7">SLC22A7</a></li> <li><a href="/wiki/SLC22A8" title="SLC22A8">SLC22A8</a></li> <li><a href="/wiki/SLC22A9" title="SLC22A9">SLC22A9</a></li> <li><a href="/wiki/SLC22A10" title="SLC22A10">SLC22A10</a></li> <li><a href="/wiki/SLC22A11" title="SLC22A11">SLC22A11</a></li> <li><a href="/wiki/SLC22A12" title="SLC22A12">SLC22A12</a></li> <li><a href="/wiki/SLC22A13" title="SLC22A13">SLC22A13</a></li> <li><a href="/wiki/SLC22A14" title="SLC22A14">SLC22A14</a></li> <li><a href="/wiki/SLC22A15" class="mw-redirect" title="SLC22A15">SLC22A15</a></li> <li><a href="/w/index.php?title=SLC22A16&action=edit&redlink=1" class="new" title="SLC22A16 (page does not exist)">SLC22A16</a></li> <li><a href="/w/index.php?title=SLC22A17&action=edit&redlink=1" class="new" title="SLC22A17 (page does not exist)">SLC22A17</a></li> <li><a href="/wiki/SLC22A18" title="SLC22A18">SLC22A18</a></li> <li><a href="/wiki/SLC22A19" class="mw-redirect" title="SLC22A19">SLC22A19</a></li> <li><a href="/w/index.php?title=SLC22A20&action=edit&redlink=1" class="new" title="SLC22A20 (page does not exist)">SLC22A20</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(23):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Na%2B-dependent_ascorbic_acid_transporter&action=edit&redlink=1" class="new" title="Na+-dependent ascorbic acid transporter (page does not exist)">Na+-dependent ascorbic acid transporter</a> <ul><li><a href="/wiki/SLC23A1" title="SLC23A1">SLC23A1</a></li> <li><a href="/wiki/SLC23A2" title="SLC23A2">SLC23A2</a></li> <li><a href="/w/index.php?title=SLC23A3&action=edit&redlink=1" class="new" title="SLC23A3 (page does not exist)">SLC23A3</a></li> <li><a href="/w/index.php?title=SLC23A4&action=edit&redlink=1" class="new" title="SLC23A4 (page does not exist)">SLC23A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(24):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Na%2B/(Ca2%2B-K%2B)_exchanger" class="mw-redirect" title="Na+/(Ca2+-K+) exchanger">Na<sup>+</sup>/(Ca<sup>2+</sup>-K<sup>+</sup>) exchanger</a> <ul><li><a href="/w/index.php?title=SLC24A1&action=edit&redlink=1" class="new" title="SLC24A1 (page does not exist)">SLC24A1</a></li> <li><a href="/w/index.php?title=SLC24A2&action=edit&redlink=1" class="new" title="SLC24A2 (page does not exist)">SLC24A2</a></li> <li><a href="/w/index.php?title=SLC24A3&action=edit&redlink=1" class="new" title="SLC24A3 (page does not exist)">SLC24A3</a></li> <li><a href="/wiki/SLC24A4" class="mw-redirect" title="SLC24A4">SLC24A4</a></li> <li><a href="/wiki/SLC24A5" class="mw-redirect" title="SLC24A5">SLC24A5</a></li> <li><a href="/w/index.php?title=SLC24A6&action=edit&redlink=1" class="new" title="SLC24A6 (page does not exist)">SLC24A6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(25):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mitochondrial_carrier" title="Mitochondrial carrier">mitochondrial carrier</a> <ul><li><a href="/wiki/SLC25A1" class="mw-redirect" title="SLC25A1">SLC25A1</a></li> <li><a href="/w/index.php?title=SLC25A2&action=edit&redlink=1" class="new" title="SLC25A2 (page does not exist)">SLC25A2</a></li> <li><a href="/wiki/SLC25A3" class="mw-redirect" title="SLC25A3">SLC25A3</a></li> <li><a href="/wiki/SLC25A4" class="mw-redirect" title="SLC25A4">SLC25A4</a></li> <li><a href="/wiki/SLC25A5" class="mw-redirect" title="SLC25A5">SLC25A5</a></li> <li><a href="/wiki/SLC25A6" class="mw-redirect" title="SLC25A6">SLC25A6</a></li> <li><a href="/wiki/Thermogenin" title="Thermogenin">SLC25A7</a></li> <li><a href="/wiki/SLC25A8" class="mw-redirect" title="SLC25A8">SLC25A8</a></li> <li><a href="/wiki/SLC25A9" class="mw-redirect" title="SLC25A9">SLC25A9</a></li> <li><a href="/wiki/SLC25A10" class="mw-redirect" title="SLC25A10">SLC25A10</a></li> <li><a href="/wiki/SLC25A11" class="mw-redirect" title="SLC25A11">SLC25A11</a></li> <li><a href="/wiki/SLC25A12" class="mw-redirect" title="SLC25A12">SLC25A12</a></li> <li><a href="/wiki/Citrin" title="Citrin">SLC25A13</a></li> <li><a href="/wiki/SLC25A14" class="mw-redirect" title="SLC25A14">SLC25A14</a></li> <li><a href="/wiki/Ornithine_translocase" title="Ornithine translocase">SLC25A15</a></li> <li><a href="/wiki/SLC25A16" title="SLC25A16">SLC25A16</a></li> <li><a href="/wiki/SLC25A17" class="mw-redirect" title="SLC25A17">SLC25A17</a></li> <li><a href="/w/index.php?title=SLC25A18&action=edit&redlink=1" class="new" title="SLC25A18 (page does not exist)">SLC25A18</a></li> <li><a href="/wiki/SLC25A19" class="mw-redirect" title="SLC25A19">SLC25A19</a></li> <li><a href="/wiki/Carnitine-acylcarnitine_translocase" title="Carnitine-acylcarnitine translocase">SLC25A20</a></li> <li><a href="/wiki/SLC25A21" class="mw-redirect" title="SLC25A21">SLC25A21</a></li> <li><a href="/wiki/SLC25A22" title="SLC25A22">SLC25A22</a></li> <li><a href="/w/index.php?title=SLC25A23&action=edit&redlink=1" class="new" title="SLC25A23 (page does not exist)">SLC25A23</a></li> <li><a href="/wiki/SLC25A24" class="mw-redirect" title="SLC25A24">SLC25A24</a></li> <li><a href="/w/index.php?title=SLC25A25&action=edit&redlink=1" class="new" title="SLC25A25 (page does not exist)">SLC25A25</a></li> <li><a href="/w/index.php?title=SLC25A26&action=edit&redlink=1" class="new" title="SLC25A26 (page does not exist)">SLC25A26</a></li> <li><a href="/wiki/SLC25A27" class="mw-redirect" title="SLC25A27">SLC25A27</a></li> <li><a href="/w/index.php?title=SLC25A28&action=edit&redlink=1" class="new" title="SLC25A28 (page does not exist)">SLC25A28</a></li> <li><a href="/wiki/SLC25A29" title="SLC25A29">SLC25A29</a></li> <li><a href="/w/index.php?title=SLC25A30&action=edit&redlink=1" class="new" title="SLC25A30 (page does not exist)">SLC25A30</a></li> <li><a href="/wiki/SLC25A31" class="mw-redirect" title="SLC25A31">SLC25A31</a></li> <li><a href="/wiki/SLC25A32" class="mw-redirect" title="SLC25A32">SLC25A32</a></li> <li><a href="/w/index.php?title=SLC25A33&action=edit&redlink=1" class="new" title="SLC25A33 (page does not exist)">SLC25A33</a></li> <li><a href="/w/index.php?title=SLC25A34&action=edit&redlink=1" class="new" title="SLC25A34 (page does not exist)">SLC25A34</a></li> <li><a href="/w/index.php?title=SLC25A35&action=edit&redlink=1" class="new" title="SLC25A35 (page does not exist)">SLC25A35</a></li> <li><a href="/w/index.php?title=SLC25A36&action=edit&redlink=1" class="new" title="SLC25A36 (page does not exist)">SLC25A36</a></li> <li><a href="/wiki/SLC25A37" class="mw-redirect" title="SLC25A37">SLC25A37</a></li> <li><a href="/wiki/SLC25A38" class="mw-redirect" title="SLC25A38">SLC25A38</a></li> <li><a href="/wiki/SLC25A39" title="SLC25A39">SLC25A39</a></li> <li><a href="/w/index.php?title=SLC25A40&action=edit&redlink=1" class="new" title="SLC25A40 (page does not exist)">SLC25A40</a></li> <li><a href="/w/index.php?title=SLC25A41&action=edit&redlink=1" class="new" title="SLC25A41 (page does not exist)">SLC25A41</a></li> <li><a href="/w/index.php?title=SLC25A42&action=edit&redlink=1" class="new" title="SLC25A42 (page does not exist)">SLC25A42</a></li> <li><a href="/w/index.php?title=SLC25A43&action=edit&redlink=1" class="new" title="SLC25A43 (page does not exist)">SLC25A43</a></li> <li><a href="/w/index.php?title=SLC25A44&action=edit&redlink=1" class="new" title="SLC25A44 (page does not exist)">SLC25A44</a></li> <li><a href="/w/index.php?title=SLC25A45&action=edit&redlink=1" class="new" title="SLC25A45 (page does not exist)">SLC25A45</a></li> <li><a href="/wiki/SLC25A46" title="SLC25A46">SLC25A46</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(26):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Multifunctional_anion_exchanger&action=edit&redlink=1" class="new" title="Multifunctional anion exchanger (page does not exist)">multifunctional anion exchanger</a> <ul><li><a href="/w/index.php?title=SLC26A1&action=edit&redlink=1" class="new" title="SLC26A1 (page does not exist)">SLC26A1</a></li> <li><a href="/wiki/SLC26A2" class="mw-redirect" title="SLC26A2">SLC26A2</a></li> <li><a href="/wiki/SLC26A3" class="mw-redirect" title="SLC26A3">SLC26A3</a></li> <li><a href="/wiki/Pendrin" title="Pendrin">SLC26A4</a></li> <li><a href="/wiki/SLC26A5" class="mw-redirect" title="SLC26A5">SLC26A5</a></li> <li><a href="/wiki/SLC26A6" title="SLC26A6">SLC26A6</a></li> <li><a href="/wiki/SLC26A7" class="mw-redirect" title="SLC26A7">SLC26A7</a></li> <li><a href="/wiki/SLC26A8" title="SLC26A8">SLC26A8</a></li> <li><a href="/w/index.php?title=SLC26A9&action=edit&redlink=1" class="new" title="SLC26A9 (page does not exist)">SLC26A9</a></li> <li><a href="/w/index.php?title=SLC26A10&action=edit&redlink=1" class="new" title="SLC26A10 (page does not exist)">SLC26A10</a></li> <li><a href="/w/index.php?title=SLC26A11&action=edit&redlink=1" class="new" title="SLC26A11 (page does not exist)">SLC26A11</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(27):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">fatty acid transport proteins</a> <ul><li><a href="/wiki/SLC27A1" class="mw-redirect" title="SLC27A1">SLC27A1</a></li> <li><a href="/wiki/SLC27A2" class="mw-redirect" title="SLC27A2">SLC27A2</a></li> <li><a href="/wiki/SLC27A3" title="SLC27A3">SLC27A3</a></li> <li><a href="/wiki/SLC27A4" class="mw-redirect" title="SLC27A4">SLC27A4</a></li> <li><a href="/wiki/SLC27A5" title="SLC27A5">SLC27A5</a></li> <li><a href="/wiki/SLC27A6" title="SLC27A6">SLC27A6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(28):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Na%2B-coupled_nucleoside_transport&action=edit&redlink=1" class="new" title="Na+-coupled nucleoside transport (page does not exist)">Na<sup>+</sup>-coupled nucleoside transport</a> (<a href="/wiki/SLC28A1" class="mw-redirect" title="SLC28A1">SLC28A1</a> <ul><li><a href="/wiki/SLC28A2" class="mw-redirect" title="SLC28A2">SLC28A2</a></li> <li><a href="/w/index.php?title=SLC28A3&action=edit&redlink=1" class="new" title="SLC28A3 (page does not exist)">SLC28A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(29):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Facilitative_nucleoside_transporter&action=edit&redlink=1" class="new" title="Facilitative nucleoside transporter (page does not exist)">facilitative nucleoside transporter</a> <ul><li><a href="/wiki/SLC29A1" class="mw-redirect" title="SLC29A1">SLC29A1</a></li> <li><a href="/wiki/SLC29A2" class="mw-redirect" title="SLC29A2">SLC29A2</a></li> <li><a href="/w/index.php?title=SLC29A3&action=edit&redlink=1" class="new" title="SLC29A3 (page does not exist)">SLC29A3</a></li> <li><a href="/wiki/SLC29A4" class="mw-redirect" title="SLC29A4">SLC29A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(30):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Zinc_efflux" class="mw-redirect" title="Zinc efflux">zinc efflux</a> <ul><li><a href="/wiki/SLC30A1" class="mw-redirect" title="SLC30A1">SLC30A1</a></li> <li><a href="/w/index.php?title=SLC30A2&action=edit&redlink=1" class="new" title="SLC30A2 (page does not exist)">SLC30A2</a></li> <li><a href="/wiki/SLC30A3" class="mw-redirect" title="SLC30A3">SLC30A3</a></li> <li><a href="/wiki/SLC30A4" class="mw-redirect" title="SLC30A4">SLC30A4</a></li> <li><a href="/w/index.php?title=SLC30A5&action=edit&redlink=1" class="new" title="SLC30A5 (page does not exist)">SLC30A5</a></li> <li><a href="/w/index.php?title=SLC30A6&action=edit&redlink=1" class="new" title="SLC30A6 (page does not exist)">SLC30A6</a></li> <li><a href="/wiki/SLC30A7" class="mw-redirect" title="SLC30A7">SLC30A7</a></li> <li><a href="/wiki/SLC30A8" class="mw-redirect" title="SLC30A8">SLC30A8</a></li> <li><a href="/w/index.php?title=SLC30A9&action=edit&redlink=1" class="new" title="SLC30A9 (page does not exist)">SLC30A9</a></li> <li><a href="/wiki/SLC30A10" class="mw-redirect" title="SLC30A10">SLC30A10</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC31–40" style="font-size:114%;margin:0 4em">SLC31–40</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(31):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Copper" title="Copper">copper</a> transporter <ul><li><a href="/wiki/SLC31A1" class="mw-redirect" title="SLC31A1">SLC31A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(32):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vesicular_glutamate_transporter_1" title="Vesicular glutamate transporter 1">Vesicular glutamate transporter 1</a> <ul><li><a href="/wiki/SLC32A1" class="mw-redirect" title="SLC32A1">SLC32A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(33):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetyl-CoA" title="Acetyl-CoA">Acetyl-CoA</a> transporter <ul><li><a href="/wiki/SLC33A1" class="mw-redirect" title="SLC33A1">SLC33A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(34):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Type_II_Na%2B-phosphate_cotransporter&action=edit&redlink=1" class="new" title="Type II Na+-phosphate cotransporter (page does not exist)">type II Na<sup>+</sup>-phosphate cotransporter</a> <ul><li><a href="/wiki/SLC34A1" class="mw-redirect" title="SLC34A1">SLC34A1</a></li> <li><a href="/wiki/SLC34A2" class="mw-redirect" title="SLC34A2">SLC34A2</a></li> <li><a href="/wiki/SLC34A3" class="mw-redirect" title="SLC34A3">SLC34A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(35):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Nucleoside-sugar_transporter&action=edit&redlink=1" class="new" title="Nucleoside-sugar transporter (page does not exist)">nucleoside-sugar transporter</a> <ul><li><a href="/wiki/SLC35A1" class="mw-redirect" title="SLC35A1">SLC35A1</a></li> <li><a href="/wiki/SLC35A2" class="mw-redirect" title="SLC35A2">SLC35A2</a></li> <li><a href="/w/index.php?title=SLC35A3&action=edit&redlink=1" class="new" title="SLC35A3 (page does not exist)">SLC35A3</a></li> <li><a href="/w/index.php?title=SLC35A4&action=edit&redlink=1" class="new" title="SLC35A4 (page does not exist)">SLC35A4</a></li> <li><a href="/w/index.php?title=SLC35A5&action=edit&redlink=1" class="new" title="SLC35A5 (page does not exist)">SLC35A5</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLC35B1&action=edit&redlink=1" class="new" title="SLC35B1 (page does not exist)">SLC35B1</a></li> <li><a href="/wiki/SLC35B2" class="mw-redirect" title="SLC35B2">SLC35B2</a></li> <li><a href="/w/index.php?title=SLC35B3&action=edit&redlink=1" class="new" title="SLC35B3 (page does not exist)">SLC35B3</a></li> <li><a href="/wiki/SLC35B4" class="mw-redirect" title="SLC35B4">SLC35B4</a></li></ul></li> <li> <ul><li><a href="/wiki/SLC35C1" class="mw-redirect" title="SLC35C1">SLC35C1</a></li> <li><a href="/wiki/SLC35C2" title="SLC35C2">SLC35C2</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLC35D1&action=edit&redlink=1" class="new" title="SLC35D1 (page does not exist)">SLC35D1</a></li> <li><a href="/w/index.php?title=SLC35D2&action=edit&redlink=1" class="new" title="SLC35D2 (page does not exist)">SLC35D2</a></li> <li><a href="/w/index.php?title=SLC35D3&action=edit&redlink=1" class="new" title="SLC35D3 (page does not exist)">SLC35D3</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLC35E1&action=edit&redlink=1" class="new" title="SLC35E1 (page does not exist)">SLC35E1</a></li> <li><a href="/w/index.php?title=SLC35E2&action=edit&redlink=1" class="new" title="SLC35E2 (page does not exist)">SLC35E2</a></li> <li><a href="/w/index.php?title=SLC35E3&action=edit&redlink=1" class="new" title="SLC35E3 (page does not exist)">SLC35E3</a></li> <li><a href="/w/index.php?title=SLC35E4&action=edit&redlink=1" class="new" title="SLC35E4 (page does not exist)">SLC35E4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(36):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proton-coupled_amino-acid_transporter" class="mw-redirect" title="Proton-coupled amino-acid transporter">proton-coupled amino-acid transporter</a> <ul><li><a href="/wiki/SLC36A1" class="mw-redirect" title="SLC36A1">SLC36A1</a></li> <li><a href="/wiki/SLC36A2" class="mw-redirect" title="SLC36A2">SLC36A2</a></li> <li><a href="/w/index.php?title=SLC36A3&action=edit&redlink=1" class="new" title="SLC36A3 (page does not exist)">SLC36A3</a></li> <li><a href="/w/index.php?title=SLC36A4&action=edit&redlink=1" class="new" title="SLC36A4 (page does not exist)">SLC36A4</a><a href="/wiki/SLC36A2" class="mw-redirect" title="SLC36A2">36A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(37):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Sugar-phosphate/phosphate_exchanger&action=edit&redlink=1" class="new" title="Sugar-phosphate/phosphate exchanger (page does not exist)">sugar-phosphate/phosphate exchanger</a> <ul><li><a href="/wiki/SLC37A1" class="mw-redirect" title="SLC37A1">SLC37A1</a></li> <li><a href="/wiki/SLC37A2" class="mw-redirect" title="SLC37A2">SLC37A2</a></li> <li><a href="/w/index.php?title=SLC37A3&action=edit&redlink=1" class="new" title="SLC37A3 (page does not exist)">SLC37A3</a></li> <li><a href="/wiki/SLC37A4" class="mw-redirect" title="SLC37A4">SLC37A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(38):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=System_A_%26_N,_sodium-coupled_neutral_amino-acid_transporter&action=edit&redlink=1" class="new" title="System A & N, sodium-coupled neutral amino-acid transporter (page does not exist)">System A & N, sodium-coupled neutral amino-acid transporter</a> <ul><li><a href="/wiki/SLC38A1" title="SLC38A1">SLC38A1</a></li> <li><a href="/wiki/SLC38A2" class="mw-redirect" title="SLC38A2">SLC38A2</a></li> <li><a href="/wiki/SLC38A3" class="mw-redirect" title="SLC38A3">SLC38A3</a></li> <li><a href="/w/index.php?title=SLC38A4&action=edit&redlink=1" class="new" title="SLC38A4 (page does not exist)">SLC38A4</a></li> <li><a href="/wiki/SLC38A5" title="SLC38A5">SLC38A5</a></li> <li><a href="/w/index.php?title=SLC38A6&action=edit&redlink=1" class="new" title="SLC38A6 (page does not exist)">SLC38A6</a></li> <li><a href="/wiki/SLC38A10" class="mw-redirect" title="SLC38A10">SLC38A10</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(39):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Metal_ion_transporter" class="mw-redirect" title="Metal ion transporter">metal ion transporter</a> <ul><li><a href="/wiki/SLC39A1" class="mw-redirect" title="SLC39A1">SLC39A1</a></li> <li><a href="/wiki/SLC39A2" class="mw-redirect" title="SLC39A2">SLC39A2</a></li> <li><a href="/wiki/SLC39A3" class="mw-redirect" title="SLC39A3">SLC39A3</a></li> <li><a href="/wiki/SLC39A4" class="mw-redirect" title="SLC39A4">SLC39A4</a></li> <li><a href="/w/index.php?title=SLC39A5&action=edit&redlink=1" class="new" title="SLC39A5 (page does not exist)">SLC39A5</a></li> <li><a href="/wiki/SLC39A6" class="mw-redirect" title="SLC39A6">SLC39A6</a></li> <li><a href="/wiki/SLC39A7" class="mw-redirect" title="SLC39A7">SLC39A7</a></li> <li><a href="/wiki/SLC39A8" class="mw-redirect" title="SLC39A8">SLC39A8</a></li> <li><a href="/wiki/SLC39A9" class="mw-redirect" title="SLC39A9">SLC39A9</a></li> <li><a href="/wiki/SLC39A10" class="mw-redirect" title="SLC39A10">SLC39A10</a></li> <li><a href="/wiki/SLC39A11" title="SLC39A11">SLC39A11</a></li> <li><a href="/wiki/SLC39A12" class="mw-redirect" title="SLC39A12">SLC39A12</a></li> <li><a href="/w/index.php?title=SLC39A13&action=edit&redlink=1" class="new" title="SLC39A13 (page does not exist)">SLC39A13</a></li> <li><a href="/w/index.php?title=SLC39A14&action=edit&redlink=1" class="new" title="SLC39A14 (page does not exist)">SLC39A14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(40):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Basolateral_iron_transporter&action=edit&redlink=1" class="new" title="Basolateral iron transporter (page does not exist)">basolateral iron transporter</a> <ul><li><a href="/wiki/Ferroportin" title="Ferroportin">SLC40A1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC41–48" style="font-size:114%;margin:0 4em">SLC41–48</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(41):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Magnesium_transporter_E" title="Magnesium transporter E">Magnesium transporter E</a> <ul><li><a href="/wiki/SLC41A1" title="SLC41A1">SLC41A1</a></li> <li><a href="/w/index.php?title=SLC41A2&action=edit&redlink=1" class="new" title="SLC41A2 (page does not exist)">SLC41A2</a></li> <li><a href="/wiki/SLC41A3" title="SLC41A3">SLC41A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(42):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ammonia_transporter" title="Ammonia transporter">Ammonia transporter</a> <ul><li><a href="/wiki/RHAG" title="RHAG">RhAG</a></li> <li><a href="/wiki/RHBG" title="RHBG">RhBG</a></li> <li><a href="/wiki/RHCG" title="RHCG">RhCG</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(43):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Na%2B-independent,_system-L_like_amino-acid_transporter&action=edit&redlink=1" class="new" title="Na+-independent, system-L like amino-acid transporter (page does not exist)">Na<sup>+</sup>-independent, system-L like amino-acid transporter</a> <ul><li><a href="/wiki/SLC43A1" class="mw-redirect" title="SLC43A1">SLC43A1</a></li> <li><a href="/w/index.php?title=SLC43A2&action=edit&redlink=1" class="new" title="SLC43A2 (page does not exist)">SLC43A2</a></li> <li><a href="/w/index.php?title=SLC43A3&action=edit&redlink=1" class="new" title="SLC43A3 (page does not exist)">SLC43A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(44):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Choline-like_transporter&action=edit&redlink=1" class="new" title="Choline-like transporter (page does not exist)">Choline-like transporter</a> <ul><li><a href="/wiki/SLC44A1" class="mw-redirect" title="SLC44A1">SLC44A1</a></li> <li><a href="/wiki/SLC44A2" class="mw-redirect" title="SLC44A2">SLC44A2</a></li> <li><a href="/w/index.php?title=SLC44A3&action=edit&redlink=1" class="new" title="SLC44A3 (page does not exist)">SLC44A3</a></li> <li><a href="/wiki/SLC44A4" class="mw-redirect" title="SLC44A4">SLC44A4</a></li> <li><a href="/w/index.php?title=SLC44A5&action=edit&redlink=1" class="new" title="SLC44A5 (page does not exist)">SLC44A5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(45):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Putative_sugar_transporter&action=edit&redlink=1" class="new" title="Putative sugar transporter (page does not exist)">Putative sugar transporter</a> <ul><li><a href="/wiki/SLC45A1" title="SLC45A1">SLC45A1</a></li> <li><a href="/wiki/SLC45A2" class="mw-redirect" title="SLC45A2">SLC45A2</a></li> <li><a href="/w/index.php?title=SLC54A3&action=edit&redlink=1" class="new" title="SLC54A3 (page does not exist)">SLC54A3</a></li> <li><a href="/wiki/SLC45A4" title="SLC45A4">SLC45A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(46):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Folate_transporter&action=edit&redlink=1" class="new" title="Folate transporter (page does not exist)">Folate transporter</a> <ul><li><a href="/wiki/SLC46A1" class="mw-redirect" title="SLC46A1">SLC46A1</a></li> <li><a href="/w/index.php?title=SLC46A2&action=edit&redlink=1" class="new" title="SLC46A2 (page does not exist)">SLC46A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(47):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Multi-antimicrobial_extrusion_protein" title="Multi-antimicrobial extrusion protein">multidrug and toxin extrusion</a> <ul><li><a href="/wiki/SLC47A1" class="mw-redirect" title="SLC47A1">SLC47A1</a></li> <li><a href="/wiki/SLC47A2" class="mw-redirect" title="SLC47A2">SLC47A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(48):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Heme_transporter" title="Heme transporter">Heme transporter</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLCO1–4" style="font-size:114%;margin:0 4em">SLCO1–4</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SLCO1A2" class="mw-redirect" title="SLCO1A2">O1A2</a></li> <li><a href="/wiki/SLCO1B1" class="mw-redirect" title="SLCO1B1">O1B1</a></li> <li><a href="/wiki/SLCO1B3" class="mw-redirect" title="SLCO1B3">O1B3</a></li> <li><a href="/wiki/SLCO2B1" class="mw-redirect" title="SLCO2B1">O2B1</a></li> <li><a href="/wiki/SLCO3A1" class="mw-redirect" title="SLCO3A1">O431</a></li> <li><a href="/wiki/SLCO4A1" class="mw-redirect" title="SLCO4A1">O4A1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Ion_pumps" style="font-size:114%;margin:0 4em"><a href="/wiki/Ion_transporter" title="Ion transporter">Ion pumps</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Symporter" title="Symporter">Symporter</a>, <a href="/wiki/Cotransporter" title="Cotransporter">Cotransporter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Na-K-Cl_cotransporter" class="mw-redirect" title="Na-K-Cl cotransporter">Na<sup>+</sup>/K<sup>+</sup>,Cl<sup>−</sup></a></li> <li><a href="/wiki/Sodium/phosphate_cotransporter" title="Sodium/phosphate cotransporter">Na<sup>+</sup>/P<sub>i</sub>3</a></li> <li><a href="/wiki/Sodium-chloride_symporter" title="Sodium-chloride symporter">Na<sup>+</sup>/Cl<sup>−</sup></a></li> <li><a href="/wiki/Sodium-glucose_transport_proteins" title="Sodium-glucose transport proteins">Na<sup>+</sup>/glucose</a></li> <li><a href="/wiki/Sodium-iodide_symporter" class="mw-redirect" title="Sodium-iodide symporter">Na<sup>+</sup>/I<sup>−</sup></a></li> <li><a href="/wiki/Chloride_potassium_symporter" title="Chloride potassium symporter">Cl<sup>−</sup>/K<sup>+</sup></a> <ul><li><a href="/wiki/Chloride_potassium_symporter_4" title="Chloride potassium symporter 4">4</a></li> <li><a href="/wiki/Chloride_potassium_symporter_5" title="Chloride potassium symporter 5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Antiporter" title="Antiporter">Antiporter (exchanger)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium%E2%80%93hydrogen_antiporter" title="Sodium–hydrogen antiporter">Na<sup>+</sup>/H<sup>+</sup></a></li> <li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Na<sup>+</sup>/Ca<sup>2+</sup></a> <ul><li><a href="/wiki/Potassium-dependent_sodium-calcium_exchanger" title="Potassium-dependent sodium-calcium exchanger">Na<sup>+</sup>/(Ca<sup>2+</sup>-K<sup>+</sup></a>) - <a href="/wiki/Band_3" class="mw-redirect" title="Band 3">Cl<sup>−</sup>/<span class="chemf nowrap">HCO<span class="nowrap"><span style="display:inline-block;margin-bottom:-0.3em;vertical-align:-0.4em;line-height:1em;font-size:80%;text-align:left"><sup style="font-size:inherit;line-height:inherit;vertical-align:baseline">−</sup><br /><sub style="font-size:inherit;line-height:inherit;vertical-align:baseline">3</sub></span></span></span> (Band 3)</a></li></ul></li> <li><a href="/wiki/Cl-formate_exchanger" class="mw-redirect" title="Cl-formate exchanger">Cl<sup>−</sup>-formate</a></li> <li><a href="/wiki/Cl-oxalate_exchanger" title="Cl-oxalate exchanger">Cl<sup>−</sup>-oxalate</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite; padding: 0px;"><div><i>see also <a href="/wiki/Template:Solute_carrier_disorders" title="Template:Solute carrier disorders">solute carrier disorders</a></i></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" 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