CINXE.COM

<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" lang="en-US"> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="viewport" content="width=device-width, initial-scale=1, user-scalable=yes">  <link rel="pingback" href="https://genetics.med.upenn.edu/xmlrpc.php" /> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' />  <title>FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity - Penn Genetics</title> <link rel="canonical" href="https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity - Penn Genetics" /> <meta property="og:description" content="FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity. Yitzhak Reizel, Ashleigh Morgan, Long Gao, Jonathan Schug, Sarmistha Mukherjee, Meil铆n Fern谩ndez Garc铆a, Greg Donahue, Joseph A. Baur, Kenneth S. Zaret, Klaus H. Kaestner." /> <meta property="og:url" content="https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/" /> <meta property="og:site_name" content="Penn Genetics" /> <meta property="article:published_time" content="2021-02-26T15:32:18+00:00" /> <meta property="article:modified_time" content="2022-05-02T19:08:55+00:00" /> <meta name="author" content="Kimberly Runyan" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:label1" content="Written by" /> <meta name="twitter:data1" content="Kimberly Runyan" /> <meta name="twitter:label2" content="Est. reading time" /> <meta name="twitter:data2" content="1 minute" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/","url":"https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/","name":"FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity - Penn Genetics","isPartOf":{"@id":"https://genetics.med.upenn.edu/#website"},"datePublished":"2021-02-26T15:32:18+00:00","dateModified":"2022-05-02T19:08:55+00:00","author":{"@id":"https://genetics.med.upenn.edu/#/schema/person/b1d553e62aea0e27398c8cca652238c4"},"breadcrumb":{"@id":"https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/"]}]},{"@type":"BreadcrumbList","@id":"https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://genetics.med.upenn.edu/"},{"@type":"ListItem","position":2,"name":"FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity"}]},{"@type":"WebSite","@id":"https://genetics.med.upenn.edu/#website","url":"https://genetics.med.upenn.edu/","name":"Penn Genetics","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://genetics.med.upenn.edu/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https://genetics.med.upenn.edu/#/schema/person/b1d553e62aea0e27398c8cca652238c4","name":"Kimberly Runyan","sameAs":["https://genetics.med.upenn.edu"],"url":"https://genetics.med.upenn.edu/author/kimberlygenetics/"}]}</script>  <link rel="alternate" type="application/rss+xml" title="Penn Genetics » FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity Comments Feed" href="https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/feed/" /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/genetics.med.upenn.edu\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style type="text/css"> #wpadminbar #wp-admin-bar-my-networks > .ab-item:first-child:before { content: "\f325"; top: 3px; } </style> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://genetics.med.upenn.edu/wp-includes/css/dist/block-library/style.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='classic-theme-styles-inline-css' type='text/css'> /*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}:where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;}:where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='ctf_styles-css' href='https://genetics.med.upenn.edu/wp-content/plugins/custom-twitter-feeds/css/ctf-styles.min.css?ver=2.2.5' type='text/css' media='all' /> <link rel='stylesheet' id='upcoming_events-css' href='https://genetics.med.upenn.edu/wp-content/plugins/livewhale_events_integration//css/style.css?ver=1.0.0' type='text/css' media='all' /> <link rel='stylesheet' id='style-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/style.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='fontawesome-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/assets/css/font-awesome.min.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='lightbox-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/css/lightbox.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='bxslidercss-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/css/jquery.bxslider.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='animations-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/css/animations.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <link rel="https://api.w.org/" href="https://genetics.med.upenn.edu/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://genetics.med.upenn.edu/wp-json/wp/v2/posts/1841" /><link rel='shortlink' href='https://genetics.med.upenn.edu/?p=1841' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://genetics.med.upenn.edu/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fgenetics.med.upenn.edu%2Ffoxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://genetics.med.upenn.edu/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fgenetics.med.upenn.edu%2Ffoxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity%2F&format=xml" /> <link rel="icon" href="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-32x32.png" sizes="32x32" /> <link rel="icon" href="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-192x192.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-180x180.png" /> <meta name="msapplication-TileImage" content="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-270x270.png" /> </head> <body class="post-template-default single single-post postid-1841 single-format-standard">  <div class="sidenav"> <div class="sidenav-content"> <div class="closebtn"><a class="menu-close">×</a></div> <nav class="navigation"> <div class="menu-top-navigation-container"><ul id="menu-top-navigation" class="mobile-nav"><li id="menu-item-1240" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1240"><a href="https://genetics.med.upenn.edu/"><span>Home</span></a></li> <li id="menu-item-1226" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1226"><a href="https://genetics.med.upenn.edu/cores/"><span>Cores</span></a> <ul class="sub-menu"> <li id="menu-item-1243" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1243"><a href="https://genetics.med.upenn.edu/cores/cell-center-stockroom/">Cell Center Stockroom</a></li> <li id="menu-item-1242" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1242"><a href="https://genetics.med.upenn.edu/cores/cell-center-services/">Cell Center Services</a></li> <li id="menu-item-1229" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1229"><a href="https://genetics.med.upenn.edu/cores/pgsc/">Penn Genomic and Sequencing Core</a></li> <li id="menu-item-1227" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1227"><a href="https://genetics.med.upenn.edu/cores/genetic-diagnostic-laboratory/">Genetic Diagnostic Laboratory</a></li> <li id="menu-item-1230" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1230"><a href="https://genetics.med.upenn.edu/cores/tcmf/">Transgenic and Chimeric Mouse Facility</a></li> </ul> </li> <li id="menu-item-1239" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1239"><a href="https://genetics.med.upenn.edu/faculty/"><span>Faculty</span></a></li> <li id="menu-item-1231" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1231"><a href="https://genetics.med.upenn.edu/education/"><span>Education</span></a> <ul class="sub-menu"> <li id="menu-item-1237" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1237"><a href="https://genetics.med.upenn.edu/education/undergraduate/">Undergraduate Education</a></li> <li id="menu-item-1233" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1233"><a href="https://genetics.med.upenn.edu/education/graduate/">Graduate Studies</a></li> <li id="menu-item-1236" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1236"><a href="https://genetics.med.upenn.edu/education/postdoctoral/">Postdoctoral Programs</a></li> <li id="menu-item-1235" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1235"><a href="https://genetics.med.upenn.edu/education/post-baccalaureate/">Post-Baccalaureate Education</a></li> <li id="menu-item-1232" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1232"><a href="https://genetics.med.upenn.edu/education/training-grant/">Genetics Training Grant</a></li> <li id="menu-item-1234" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1234"><a href="https://genetics.med.upenn.edu/education/md-phd-program/">MD / PHD Programs</a></li> </ul> </li> <li id="menu-item-1241" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1241"><a href="https://genetics.med.upenn.edu/news/"><span>News</span></a> <ul class="sub-menu"> <li id="menu-item-1215" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1215"><a href="https://genetics.med.upenn.edu/category/announcements/">Announcements</a></li> <li id="menu-item-1217" class="menu-item menu-item-type-taxonomy menu-item-object-category current-post-ancestor current-menu-parent current-post-parent menu-item-1217"><a href="https://genetics.med.upenn.edu/category/publications/">Publications</a></li> <li id="menu-item-1216" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1216"><a href="https://genetics.med.upenn.edu/category/in-the-news/">In the News</a></li> </ul> </li> <li id="menu-item-1238" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1238"><a href="https://genetics.med.upenn.edu/events/"><span>Events</span></a></li> <li id="menu-item-1225" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1225"><a href="https://genetics.med.upenn.edu/contact/"><span>Contact</span></a></li> </ul></div> </nav> <div class="mobile-contact"> <div class="social"> <ul> <li> <a href="https://twitter.com/PennGenetics" target="_blank" title=""> <div class="social-icon"> <i class="fab fa-twitter" aria-hidden="true"></i> </div> </a> </li> </ul> </div> </div> </div> </div>   <div id="wrap" class="clear width-100"> <header> <div class="logo-title-wrap clear"> <div class="inner-container clear"> <div class="site-title"> <div class="menu-open"><i class="fa fa-bars"></i></div> <a href="https://genetics.med.upenn.edu/">Department of Genetics</a> </div> <div class="perelman-logo"> <a href="https://www.med.upenn.edu/" target="_blank"> <img src="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/psom-logo.png" alt="Perelman School of Medicine at the University of Pennsylvania" title="Perelman School of Medicine at the University of Pennsylvania" /> </a> </div> </div> </div> <div class="nav-wrap clear"> <nav class="navigation drops"><div class="menu-top-navigation-container"><ul id="menu-top-navigation-1" class="top-nav"><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1240"><a href="https://genetics.med.upenn.edu/"><span>Home</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1226"><a href="https://genetics.med.upenn.edu/cores/"><span>Cores</span></a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1243"><a href="https://genetics.med.upenn.edu/cores/cell-center-stockroom/">Cell Center Stockroom</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1242"><a href="https://genetics.med.upenn.edu/cores/cell-center-services/">Cell Center Services</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1229"><a href="https://genetics.med.upenn.edu/cores/pgsc/">Penn Genomic and Sequencing Core</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1227"><a href="https://genetics.med.upenn.edu/cores/genetic-diagnostic-laboratory/">Genetic Diagnostic Laboratory</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1230"><a href="https://genetics.med.upenn.edu/cores/tcmf/">Transgenic and Chimeric Mouse Facility</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1239"><a href="https://genetics.med.upenn.edu/faculty/"><span>Faculty</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1231"><a href="https://genetics.med.upenn.edu/education/"><span>Education</span></a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1237"><a href="https://genetics.med.upenn.edu/education/undergraduate/">Undergraduate Education</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1233"><a href="https://genetics.med.upenn.edu/education/graduate/">Graduate Studies</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1236"><a href="https://genetics.med.upenn.edu/education/postdoctoral/">Postdoctoral Programs</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1235"><a href="https://genetics.med.upenn.edu/education/post-baccalaureate/">Post-Baccalaureate Education</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1232"><a href="https://genetics.med.upenn.edu/education/training-grant/">Genetics Training Grant</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1234"><a href="https://genetics.med.upenn.edu/education/md-phd-program/">MD / PHD Programs</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1241"><a href="https://genetics.med.upenn.edu/news/"><span>News</span></a> <ul class="sub-menu"> <li class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1215"><a href="https://genetics.med.upenn.edu/category/announcements/">Announcements</a></li> <li class="menu-item menu-item-type-taxonomy menu-item-object-category current-post-ancestor current-menu-parent current-post-parent menu-item-1217"><a href="https://genetics.med.upenn.edu/category/publications/">Publications</a></li> <li class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1216"><a href="https://genetics.med.upenn.edu/category/in-the-news/">In the News</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1238"><a href="https://genetics.med.upenn.edu/events/"><span>Events</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1225"><a href="https://genetics.med.upenn.edu/contact/"><span>Contact</span></a></li> </ul></div></nav> </div> </header><div id="page" class="body-wrap clear sub"> <main class="blogwrap"> <div class="inner-container blog-sidebar-wrap animatedParent animateOnceclear"> <div class="post-single the-content animated fadeInUpShort clear"> <h1 class="post-title">FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity</h1> <div class="date-social clear"> <div class="date">Posted On: February 26, 2021</div> <div class="social-share"> <ul class="social-links"> <li>Share:</li> <li> <a href="https://www.facebook.com/sharer/sharer.php?u=https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/" target="blank" title="Share on Facebook"> <i class="fab fa-facebook-f" aria-hidden="true"></i> </a> </li> <li> <a href="https://twitter.com/home?status=Check%20out%20this%20article:%20FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity%20https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/" target="blank" title="Share on Twitter"> <i class="fab fa-twitter" aria-hidden="true"></i> </a> </li> <li> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://genetics.med.upenn.edu/foxa-dependent-demethylation-of-dna-initiates-epigenetic-memory-of-cellular-identity/&title=FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity" target="blank" title="Share on LinkedIn"> <i class="fab fa-linkedin" aria-hidden="true"></i> </a> </li> </ul> </div> </div> <p class="article-header__title"><strong><a href="https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00116-7" target="_blank" rel="noopener">FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity.</a></strong> Yitzhak Reizel, Ashleigh Morgan, Long Gao, Jonathan Schug, Sarmistha Mukherjee, Meil铆n Fern谩ndez Garc铆a, Greg Donahue, Joseph A. Baur, Kenneth S. Zaret, Klaus H. Kaestner.</p> <div class="article-header__wrapper"> <div class="article-header__bottom clearfix row"> <div class="col-md-6 static-md"> <div class="plum-jbs-theme"> <div class="PlumX-Popup"> <div class="ppp-container ppp-small ppp-badge"></div> </div> </div> </div> </div> </div> <div class="article-header__dropZone pb-dropzone" data-pb-dropzone="articleNavigation-Dropzone"> <div class="content-navigation clearfix" data-widget-id="54733c81-009b-4b22-b588-f003dedf997f" data-widget-name="UX3ArticleNavigation"> <div class="content-navigation__btn__wrapper--prev"></div> </div> </div> <div class="previous-next clear"> <div class="previous-post"><div class="left-arrow"><i class="fa fa-chevron-left"></i></div> Previous Post<br/> <a href="https://genetics.med.upenn.edu/variability-within-rare-cell-states-enables-multiple-paths-toward-drug-resistance/" rel="prev">Variability within rare cell states enables multiple paths toward drug resistance</a></div> <div class="next-post"><div class="right-arrow"><i class="fa fa-chevron-right"></i></div>Next Post<br/> <a href="https://genetics.med.upenn.edu/single-cell-transcriptomic-analysis-of-mihc-images-via-antigen-mapping/" rel="next">Single-cell transcriptomic analysis of mIHC images via antigen mapping</a></div> </div> </div> <aside class="animated fadeInLeftShort"> <div class="latest-posts the-content"> <h3>Latest News</h3> <ul> <li> <a href="https://genetics.med.upenn.edu/new-department-of-genetics-website-in-progress/">Genetics Website in Progress</a> </li> <li> <a href="https://genetics.med.upenn.edu/single-cell-multi-omics-analysis-of-human-pancreatic-islets-reveals-novel-cellular-states-in-type-1-diabetes/">Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes</a> </li> <li> <a href="https://genetics.med.upenn.edu/single-cell-analysis-of-the-human-pancreas-in-type-2-diabetes-using-multi-spectral-imaging-mass-cytometry/">Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry</a> </li> <li> <a href="https://genetics.med.upenn.edu/temporal-manipulation-of-cdkl5-reveals-essential-postdevelopmental-functions-and-reversible-cdkl5-deficiency-disorder-related-deficits/">Temporal manipulation of Cdkl5 reveals essential postdevelopmental functions and reversible CDKL5 deficiency disorder鈥搑elated deficits</a> </li> </ul> </div> <div class="categories the-content"> <h3>Categories</h3> <ul class="archive"> <li class="cat-item cat-item-2"><a href="https://genetics.med.upenn.edu/category/announcements/">Announcements</a> </li> <li class="cat-item cat-item-3"><a href="https://genetics.med.upenn.edu/category/in-the-news/">In the News</a> </li> <li class="cat-item cat-item-4"><a href="https://genetics.med.upenn.edu/category/news/">News</a> </li> <li class="cat-item cat-item-5"><a href="https://genetics.med.upenn.edu/category/publications/">Publications</a> </li> <li class="cat-item cat-item-1"><a href="https://genetics.med.upenn.edu/category/uncategorized/">Uncategorized</a> </li> </ul> </div> </aside> </div> </main> </div> <footer class="clear">  <section class="footer-main clear"> <div class="columns-wrap clear"> <div class="map-info" style="background-image: url('https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/footer-bg.jpg');"> <div class="trans-bg clear"> <div class="map-info-wrap"> <div class="map"></div> <div class="info"><p>Department of Genetics<br /> Perelman School of Medicine<br /> Clinical Research Building 500<br /> 415 Curie Blvd.<br /> University of Pennsylvania<br /> Philadelphia, PA 19104</p> </div> </div> </div> </div> <div class="search-wrap the-content"> <div class="search clear"> <h4>Search</h4> <form role="search" method="get" id="searchform" class="searchform" action="https://genetics.med.upenn.edu/"> <div class="search-fields"> <input type="text" value="" name="s" id="s" placeholder="Search Penn Genetics..." /> <button type="submit" class="search-submit" title="Search"><i class="fa fa-search" aria-hidden="true"></i></button> </div> </form> </div> <div class="social clear"> <h4>Follow Us</h4> <ul> <li> <a href="https://twitter.com/PennGenetics" target="_blank" title=""> <div class="social-icon"> <i class="fab fa-twitter" aria-hidden="true"></i> </div> </a> </li> </ul> </div> </div> </div>  <div class="copyright clear"> <div>Copyright © 2024</div> <div><p>The Trustees of the University of Pennsylvania. All Rights Reserved. Privacy Policy.</p> </div> </div>  </section>  </footer> </div>  <a href="#0" class="cd-top" title="Return to Top" alt="Return to Top">Top</a> <link rel='stylesheet' id='font-awesome-css' href='https://use.fontawesome.com/releases/v5.15.4/css/all.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/classie.js?ver=6.6.2" id="classie-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/jquery.bxslider.min.js?ver=6.6.2" id="bxslider-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/main.js?ver=6.6.2" id="main-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/jquery.min.js?ver=6.6.2" id="jquery-new-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/css3-animate-it.js?ver=6.6.2" id="animate-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/lightbox.js?ver=6.6.2" id="lightbox-js-js"></script> </body> </html>