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About: Dopaminergic
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href="http://dbpedia.org">dbpedia.org</a></span> </div> </div> </div> <div class="row pt-2"> <div class="col-xs-9 col-sm-10"> <p class="lead">Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter. Dopaminergic substances or actions increase dopamine-related activity in the brain. Dopaminergic brain pathways facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and dopamine receptors can be classified as dopaminergic, and neurons that synthesize or contain dopamine and synapses with dopamine receptors in them may also be labeled as dopaminergic. Enzymes that regulate the biosynthesis or metabolism of dopamine such as aromatic L-amino acid decarboxylase or DOPA decarboxylase, monoamine oxidase (MAO), and catechol O-methyl transferase (COMT) may be referred to as dopaminerg</p> </div> <div class="col-xs-3 col-sm-2"> <a href="#" class="thumbnail"> <img src="http://commons.wikimedia.org/wiki/Special:FilePath/Dopamine2.svg?width=300" alt="thumbnail" class="img-fluid" /> </a> </div> </div> </div> </section> <!-- page-header --> <!-- property-table --> <section> <div class="container-xl"> <div class="row"> <div class="table-responsive"> <table class="table table-hover table-sm table-light"> <thead> <tr> <th class="col-xs-3 ">Property</th> <th class="col-xs-9 px-3">Value</th> </tr> </thead> <tbody> <tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/abstract"><small>dbo:</small>abstract</a> </td><td class="col-10 text-break"><ul> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="ar" >دوباميني الفعل تعني «ذو صلة بالدوبامين» (وحرفيا «يعمل على الدوبامين»)، والدوبامين هو ناقل عصبي أحادي الأمين شائع. تزيد المواد أو الأفعال دوبامينية الفعل النشاط المتعلق بالدوبامين في الدماغ، وتُسهل البنى الدماغية دوبامينية الفعل النشاط المتعلق بالدوبامين. على سبيل المثال: يمكن أن تُصنَّف بعض البروتينات مثل ناقل الدوبامين (DAT)، ناقل أحادي الأمين الحويصلي 2 (VMAT2)، ومستقبلات الدوبامين عى أنها دوبامينية الفعل، وكذلك الأمر بالنسبة للعصبونات التي تخلِّق أو تحتوي على الدوبامين والمشابك التي تحتوي على مستقبلات الدوبامين. الإنزيمات التي تنظم التخليق الحيوي وأيض الدوبامين مثل نازعة كربوكسيل L-الحمض الأميني العطري (نازعة كربوكسيل دوبا)، أكسيداز أحادي الأمين (MAO)، ناقل O-ميثيل-كاتيكول (COMT) يمكن أن يشار إليها بدوبامينية الفعل كذلك. أيُّ مادة كيميائية داخلية أو خارجية المنشأ تعمل على التأثير على مستقبلات الدوبامين أو تحرير الدوبامين عبر أفعال غير مباشرة (مثل: العصبونات التي تتشابك مع عصبونات تحرر الدوبامين أو تعبر عن مستقبلات دوبامين) يمكن القول كذلك بأنها تملك تأثيرات دوبامينية الفعل، من الأمثلة على ذلك: أشباه أفيونيات التي تزيد تحرير الدوبامين بشكل غير مباشر في أنظمة المكافأة، وبعض الأمفيتامينات التي تزيد تحرير الدوبامين بشكل مباشر عبر الارتباط بـVMAT2 وتثبيطه.</span><small> (ar)</small></span></li> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="de" >Dopaminerg bedeutet so viel wie „auf Dopamin reagierend“ oder „Dopamin als Neurotransmitter enthaltend“. Gemeint sind meistens dopaminsensible Rezeptoren des Gehirns oder verhaltenssteuernde Gehirnareale, in denen Dopamin als Neurotransmitter fungiert (etwa das sogenannte Belohnungszentrum). Dopaminerge Nervenzellen befinden sich unter anderem in der schwarzen Substanz (Substantia nigra) und den Raphe-Kernen des Mittelhirns. Erstere sind insbesondere bei der Parkinson-Krankheit betroffen.</span><small> (de)</small></span></li> <li><span class="literal"><span property="dbo:abstract" lang="en" >Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter. Dopaminergic substances or actions increase dopamine-related activity in the brain. Dopaminergic brain pathways facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and dopamine receptors can be classified as dopaminergic, and neurons that synthesize or contain dopamine and synapses with dopamine receptors in them may also be labeled as dopaminergic. Enzymes that regulate the biosynthesis or metabolism of dopamine such as aromatic L-amino acid decarboxylase or DOPA decarboxylase, monoamine oxidase (MAO), and catechol O-methyl transferase (COMT) may be referred to as dopaminergic as well. Also, any endogenous or exogenous chemical substance that acts to affect dopamine receptors or dopamine release through indirect actions (for example, on neurons that synapse onto neurons that release dopamine or express dopamine receptors) can also be said to have dopaminergic effects, two prominent examples being opioids, which enhance dopamine release indirectly in the reward pathways, and some substituted amphetamines, which enhance dopamine release directly by binding to and inhibiting VMAT2.</span><small> (en)</small></span></li> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="es" >Dopaminérgico significa "relacionado con la actividad de la dopamina", siendo la dopamina uno de los neurotransmisores más comunes. El término generalmente se utiliza para describir a aquellas sustancias o acciones que incrementan la actividad relacionada con la dopamina en el cerebro. Aunque también se utiliza para describir aquellas estructuras cerebrales que se encuentran relacionadas con la actividad de la dopamina. Por ejemplo, ciertas proteínas tales como el transportador de dopamina (DAT), el (VMAT2), y los receptores de dopamina, pueden ser clasificados como dopaminérgicos. Las enzimas que regulan la biosíntesis o el metabolismo de la dopamina, tales como la L-aminoácido aromático descarboxilasa o la DOPA descarboxilasa, monoamino oxidasa (MAO), y la catecol-O-metiltransferasa (COMT), también pueden ser referidas como dopaminérgicas. Además cualquier sustancia química ya sea exógena o endógena que sea capaz de actuar o afectar los receptores de dopamina o la liberación de la misma a través de acciones indirectas (por ejemplo, en aquellas neuronas que hacen sinapsis sobre neuronas que liberan dopamina o expresan receptores de dopamina), se dice que tiene efectos dopaminérgicos. Entre estos últimos dos ejemplos notables son los opioides, los cuales aumentan indirectamente la liberación de dopamina en el del cerebro, y algunas que aumentan indirectamente la liberación de dopamina uniéndose e inhibiendo a la</span><small> (es)</small></span></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/thumbnail"><small>dbo:</small>thumbnail</a> </td><td class="col-10 text-break"><ul> <li><span class="literal"><a class="uri" rel="dbo:thumbnail" resource="http://commons.wikimedia.org/wiki/Special:FilePath/Dopamine2.svg?width=300" href="http://commons.wikimedia.org/wiki/Special:FilePath/Dopamine2.svg?width=300"><small>wiki-commons</small>:Special:FilePath/Dopamine2.svg?width=300</a></span></li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/wikiPageID"><small>dbo:</small>wikiPageID</a> </td><td class="col-10 text-break"><ul> <li><span class="literal"><span 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href="http://dbpedia.org/class/yago/Relation100031921"><small>yago</small>:Relation100031921</a></span></li> <li><span class="literal"><a class="uri" rel="rdf:type" resource="http://dbpedia.org/class/yago/Substance100019613" href="http://dbpedia.org/class/yago/Substance100019613"><small>yago</small>:Substance100019613</a></span></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://www.w3.org/2000/01/rdf-schema#comment"><small>rdfs:</small>comment</a> </td><td class="col-10 text-break"><ul> <li style="display:none;"><span class="literal"><span property="rdfs:comment" lang="de" >Dopaminerg bedeutet so viel wie „auf Dopamin reagierend“ oder „Dopamin als Neurotransmitter enthaltend“. Gemeint sind meistens dopaminsensible Rezeptoren des Gehirns oder verhaltenssteuernde Gehirnareale, in denen Dopamin als Neurotransmitter fungiert (etwa das sogenannte Belohnungszentrum). Dopaminerge Nervenzellen befinden sich unter anderem in der schwarzen Substanz (Substantia nigra) und den Raphe-Kernen des Mittelhirns. Erstere sind insbesondere bei der Parkinson-Krankheit betroffen.</span><small> (de)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:comment" lang="ar" >دوباميني الفعل تعني «ذو صلة بالدوبامين» (وحرفيا «يعمل على الدوبامين»)، والدوبامين هو ناقل عصبي أحادي الأمين شائع. تزيد المواد أو الأفعال دوبامينية الفعل النشاط المتعلق بالدوبامين في الدماغ، وتُسهل البنى الدماغية دوبامينية الفعل النشاط المتعلق بالدوبامين. على سبيل المثال: يمكن أن تُصنَّف بعض البروتينات مثل ناقل الدوبامين (DAT)، ناقل أحادي الأمين الحويصلي 2 (VMAT2)، ومستقبلات الدوبامين عى أنها دوبامينية الفعل، وكذلك الأمر بالنسبة للعصبونات التي تخلِّق أو تحتوي على الدوبامين والمشابك التي تحتوي على مستقبلات الدوبامين. الإنزيمات التي تنظم التخليق الحيوي وأيض الدوبامين مثل نازعة كربوكسيل L-الحمض الأميني العطري (نازعة كربوكسيل دوبا)، أكسيداز أحادي الأمين (MAO)، ناقل O-ميثيل-كاتيكول (COMT) يمكن أن يشار إليها بدوبامينية الفعل كذلك. أيُّ مادة كيميائية داخلية أو خارجية المنشأ تعمل على التأثير على م</span><small> (ar)</small></span></li> <li><span class="literal"><span property="rdfs:comment" lang="en" >Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter. Dopaminergic substances or actions increase dopamine-related activity in the brain. Dopaminergic brain pathways facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and dopamine receptors can be classified as dopaminergic, and neurons that synthesize or contain dopamine and synapses with dopamine receptors in them may also be labeled as dopaminergic. Enzymes that regulate the biosynthesis or metabolism of dopamine such as aromatic L-amino acid decarboxylase or DOPA decarboxylase, monoamine oxidase (MAO), and catechol O-methyl transferase (COMT) may be referred to as dopaminerg</span><small> (en)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:comment" lang="es" >Dopaminérgico significa "relacionado con la actividad de la dopamina", siendo la dopamina uno de los neurotransmisores más comunes. El término generalmente se utiliza para describir a aquellas sustancias o acciones que incrementan la actividad relacionada con la dopamina en el cerebro. Aunque también se utiliza para describir aquellas estructuras cerebrales que se encuentran relacionadas con la actividad de la dopamina. Por ejemplo, ciertas proteínas tales como el transportador de dopamina (DAT), el (VMAT2), y los receptores de dopamina, pueden ser clasificados como dopaminérgicos.</span><small> (es)</small></span></li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://www.w3.org/2000/01/rdf-schema#label"><small>rdfs:</small>label</a> </td><td class="col-10 text-break"><ul> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="ar" >دوباميني الفعل</span><small> (ar)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="de" >Dopaminerg</span><small> (de)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="es" >Dopaminérgico</span><small> (es)</small></span></li> <li><span class="literal"><span property="rdfs:label" lang="en" >Dopaminergic</span><small> (en)</small></span></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" 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