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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="robots" content="max-image-preview:large"> <meta name="access" content="No"> <meta name="360-site-verification" content="1268d79b5e96aecf3ff2a7dac04ad990" /> <title>A meta-analysis of laparoscopy compared with open colorectal resection for colorectal cancer | Medical Oncology</title> <meta name="twitter:site" content="@SpringerLink"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:image:alt" content="Content cover image"/> <meta name="twitter:title" content="A meta-analysis of laparoscopy compared with open colorectal resection for colorectal cancer"/> <meta name="twitter:description" content="Medical Oncology - The aim of this study was to compare the outcome of the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal..."/> <meta name="twitter:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs12032-010-9549-5/MediaObjects/12032_2010_9549_Fig1_HTML.gif"/> <meta name="journal_id" content="12032"/> <meta name="dc.title" content="A meta-analysis of laparoscopy compared with open colorectal resection for colorectal cancer"/> <meta name="dc.source" content="Medical Oncology 2010 28:4"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="Springer"/> <meta name="dc.date" content="2010-05-11"/> <meta name="dc.type" content="OriginalPaper"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2010 Springer Science+Business Media, LLC"/> <meta name="dc.rights" content="2010 Springer Science+Business Media, LLC"/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="The aim of this study was to compare the outcome of the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. We searched the Medline, Embase, and Cochrane Library and systematically reviewed the randomized controlled trials by comparing the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. Fifteen trials with 4,207 patients who reported long-term outcomes of the overall complication, mortality, and recurrence rate were included. The combined results of the individual trials showed no statistically significant difference in the odds ratio (OR) for overall recurrence (OR 0.92, 95% CI, 0.77–1.11, P&nbsp;=&nbsp;0.34), local recurrence (OR 0.81, 95% CI, 0.59–1.12, P&nbsp;=&nbsp;0.20), distant metastasis (OR 1.01, 95% CI, 0.78–1.30, P&nbsp;=&nbsp;0.95), wound-site recurrence (OR 1.97, 95% CI, 0.77–5.02, P&nbsp;=&nbsp;0.16), colorectal cancer-related mortality (OR 0.82, 95% CI, 0.66–1.02, P&nbsp;=&nbsp;0.07), colon cancer-related mortality (OR 0.85, 95% CI, 0.66–1.09, P&nbsp;=&nbsp;0.20), rectal cancer-related mortality (OR 0.76, 95% CI, 0.53–1.11, P&nbsp;=&nbsp;0.16), and overall mortality (OR 0.87, 95% CI, 0.73–1.73, P&nbsp;=&nbsp;0.11) between the laparoscopic surgery and open surgery groups. The overall complications in the laparoscopic surgery group were much lower than that in the open surgery group (OR 0.71, 95% CI, 0.58–0.87, P&nbsp;=&nbsp;0.001). This meta-analysis showed that the successful laparoscopic colorectal resection for colorectal cancer was as effective as open surgery in terms of the oncological outcomes, thereby suggesting that laparoscopic surgery can be continued in patients with colorectal cancer."/> <meta name="prism.issn" content="1559-131X"/> <meta name="prism.publicationName" content="Medical Oncology"/> <meta name="prism.publicationDate" content="2010-05-11"/> <meta name="prism.volume" content="28"/> <meta name="prism.number" content="4"/> <meta name="prism.section" content="OriginalPaper"/> <meta name="prism.startingPage" content="925"/> <meta name="prism.endingPage" content="933"/> <meta name="prism.copyright" content="2010 Springer Science+Business Media, LLC"/> <meta name="prism.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="prism.url" content="https://link.springer.com/article/10.1007/s12032-010-9549-5"/> <meta name="prism.doi" content="doi:10.1007/s12032-010-9549-5"/> <meta name="citation_pdf_url" content="https://link.springer.com/content/pdf/10.1007/s12032-010-9549-5.pdf"/> <meta name="citation_fulltext_html_url" content="https://link.springer.com/article/10.1007/s12032-010-9549-5"/> <meta name="citation_journal_title" content="Medical Oncology"/> <meta name="citation_journal_abbrev" content="Med Oncol"/> <meta name="citation_publisher" content="Springer US"/> <meta name="citation_issn" content="1559-131X"/> <meta name="citation_title" content="A meta-analysis of laparoscopy compared with open colorectal resection for colorectal cancer"/> <meta name="citation_volume" content="28"/> <meta name="citation_issue" content="4"/> <meta name="citation_publication_date" content="2011/12"/> <meta name="citation_online_date" content="2010/05/11"/> <meta name="citation_firstpage" content="925"/> <meta name="citation_lastpage" content="933"/> <meta name="citation_article_type" content="Original Paper"/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1007/s12032-010-9549-5"/> <meta name="DOI" content="10.1007/s12032-010-9549-5"/> <meta name="size" content="152976"/> <meta name="citation_doi" content="10.1007/s12032-010-9549-5"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1007/s12032-010-9549-5&api_key="/> <meta name="description" content="The aim of this study was to compare the outcome of the overall complication, mortality, and recurrence rate between laparoscopic resection and open surger"/> <meta name="dc.creator" content="Ma, Yanlei"/> <meta name="dc.creator" content="Yang, Zhe"/> <meta name="dc.creator" content="Qin, Huanlong"/> <meta name="dc.creator" content="Wang, Yu"/> <meta name="dc.subject" content="Oncology"/> <meta name="dc.subject" content="Hematology"/> <meta name="dc.subject" content="Pathology"/> <meta name="dc.subject" content="Internal Medicine"/> <meta name="citation_reference" content="citation_journal_title=N Engl J Med; 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We searched the Medline, Embase, and Cochrane Library and systematically reviewed the randomized controlled trials by comparing the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. Fifteen trials with 4,207 patients who reported long-term outcomes of the overall complication, mortality, and recurrence rate were included. The combined results of the individual trials showed no statistically significant difference in the odds ratio (OR) for overall recurrence (OR 0.92, 95% CI, 0.77–1.11, P = 0.34), local recurrence (OR 0.81, 95% CI, 0.59–1.12, P = 0.20), distant metastasis (OR 1.01, 95% CI, 0.78–1.30, P = 0.95), wound-site recurrence (OR 1.97, 95% CI, 0.77–5.02, P = 0.16), colorectal cancer-related mortality (OR 0.82, 95% CI, 0.66–1.02, P = 0.07), colon cancer-related mortality (OR 0.85, 95% CI, 0.66–1.09, P = 0.20), rectal cancer-related mortality (OR 0.76, 95% CI, 0.53–1.11, P = 0.16), and overall mortality (OR 0.87, 95% CI, 0.73–1.73, P = 0.11) between the laparoscopic surgery and open surgery groups. The overall complications in the laparoscopic surgery group were much lower than that in the open surgery group (OR 0.71, 95% CI, 0.58–0.87, P = 0.001). This meta-analysis showed that the successful laparoscopic colorectal resection for colorectal cancer was as effective as open surgery in terms of the oncological outcomes, thereby suggesting that laparoscopic surgery can be continued in patients with colorectal cancer."/> <meta property="og:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs12032-010-9549-5/MediaObjects/12032_2010_9549_Fig1_HTML.gif"/> <meta name="format-detection" content="telephone=no"> <link rel="apple-touch-icon" sizes="180x180" href=/oscar-static/img/favicons/darwin/apple-touch-icon-92e819bf8a.png> <link rel="icon" type="image/png" sizes="192x192" href=/oscar-static/img/favicons/darwin/android-chrome-192x192-6f081ca7e5.png> <link rel="icon" type="image/png" sizes="32x32" href=/oscar-static/img/favicons/darwin/favicon-32x32-1435da3e82.png> <link rel="icon" type="image/png" sizes="16x16" href=/oscar-static/img/favicons/darwin/favicon-16x16-ed57f42bd2.png> <link rel="shortcut icon" 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We searched the Medline, Embase, and Cochrane Library and systematically reviewed the randomized controlled trials by comparing the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. Fifteen trials with 4,207 patients who reported long-term outcomes of the overall complication, mortality, and recurrence rate were included. The combined results of the individual trials showed no statistically significant difference in the odds ratio (OR) for overall recurrence (OR 0.92, 95% CI, 0.77–1.11, P = 0.34), local recurrence (OR 0.81, 95% CI, 0.59–1.12, P = 0.20), distant metastasis (OR 1.01, 95% CI, 0.78–1.30, P = 0.95), wound-site recurrence (OR 1.97, 95% CI, 0.77–5.02, P = 0.16), colorectal cancer-related mortality (OR 0.82, 95% CI, 0.66–1.02, P = 0.07), colon cancer-related mortality (OR 0.85, 95% CI, 0.66–1.09, P = 0.20), rectal cancer-related mortality (OR 0.76, 95% CI, 0.53–1.11, P = 0.16), and overall mortality (OR 0.87, 95% CI, 0.73–1.73, P = 0.11) between the laparoscopic surgery and open surgery groups. The overall complications in the laparoscopic surgery group were much lower than that in the open surgery group (OR 0.71, 95% CI, 0.58–0.87, P = 0.001). This meta-analysis showed that the successful laparoscopic colorectal resection for colorectal cancer was as effective as open surgery in terms of the oncological outcomes, thereby suggesting that laparoscopic surgery can be continued in patients with colorectal cancer.","datePublished":"2010-05-11T00:00:00Z","dateModified":"2010-05-11T00:00:00Z","pageStart":"925","pageEnd":"933","sameAs":"https://doi.org/10.1007/s12032-010-9549-5","keywords":["Meta-analysis","Colorectal cancer","Surgery","Oncology","Hematology","Pathology","Internal 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alt=""> </picture> <span class="app-article-masthead__journal-title">Medical Oncology</span> </a> <a href="https://link.springer.com/journal/12032/aims-and-scope" class="app-article-masthead__submission-link" data-track="click_aims_and_scope" data-track-action="aims and scope" data-track-context="article page" data-track-label="link"> Aims and scope <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> <a href="https://submission.springernature.com/new-submission/12032/3" class="app-article-masthead__submission-link" data-track="click_submit_manuscript" data-track-context="article masthead on springerlink article page" data-track-action="submit manuscript" data-track-label="link"> Submit manuscript <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> </div> </div> </div> </section> <div class="c-article-main u-container u-mt-24 u-mb-32 l-with-sidebar" id="main-content" data-component="article-container"> <main class="u-serif js-main-column" data-track-component="article body"> <div class="c-article-header"> <header> <ul class="c-article-author-list c-article-author-list--short" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Yanlei-Ma-Aff1" data-author-popup="auth-Yanlei-Ma-Aff1" data-author-search="Ma, Yanlei">Yanlei Ma</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Zhe-Yang-Aff1" data-author-popup="auth-Zhe-Yang-Aff1" data-author-search="Yang, Zhe" data-corresp-id="c1">Zhe Yang<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Huanlong-Qin-Aff1" data-author-popup="auth-Huanlong-Qin-Aff1" data-author-search="Qin, Huanlong" data-corresp-id="c2">Huanlong Qin<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff1">1</a></sup> & </li><li class="c-article-author-list__show-more" aria-label="Show all 4 authors for this article" title="Show all 4 authors for this article">…</li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Yu-Wang-Aff1" data-author-popup="auth-Yu-Wang-Aff1" data-author-search="Wang, Yu" data-corresp-id="c3">Yu Wang<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff1">1</a></sup> </li></ul><button aria-expanded="false" class="c-article-author-list__button"><svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-chevron-down-medium"></use></svg><span>Show authors</span></button> <div data-test="article-metrics"> <ul class="app-article-metrics-bar u-list-reset"> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-accesses-medium"></use> </svg>671 <span class="app-article-metrics-bar__label">Accesses</span></p> </li> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-citations-medium"></use> </svg>30 <span class="app-article-metrics-bar__label">Citations</span></p> </li> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-altmetric-medium"></use> </svg>9 <span class="app-article-metrics-bar__label">Altmetric</span></p> </li> <li class="app-article-metrics-bar__item app-article-metrics-bar__item--metrics"> <p class="app-article-metrics-bar__details"><a href="/article/10.1007/s12032-010-9549-5/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Explore all metrics <svg class="u-icon app-article-metrics-bar__arrow-icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg></a></p> </li> </ul> </div> <div class="u-mt-32"> </div> </header> </div> <div data-article-body="true" data-track-component="article body" class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><p>The aim of this study was to compare the outcome of the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. We searched the Medline, Embase, and Cochrane Library and systematically reviewed the randomized controlled trials by comparing the overall complication, mortality, and recurrence rate between laparoscopic resection and open surgery for colorectal cancer. Fifteen trials with 4,207 patients who reported long-term outcomes of the overall complication, mortality, and recurrence rate were included. The combined results of the individual trials showed no statistically significant difference in the odds ratio (OR) for overall recurrence (OR 0.92, 95% CI, 0.77–1.11, <i>P</i> = 0.34), local recurrence (OR 0.81, 95% CI, 0.59–1.12, <i>P</i> = 0.20), distant metastasis (OR 1.01, 95% CI, 0.78–1.30, <i>P</i> = 0.95), wound-site recurrence (OR 1.97, 95% CI, 0.77–5.02, <i>P</i> = 0.16), colorectal cancer-related mortality (OR 0.82, 95% CI, 0.66–1.02, <i>P</i> = 0.07), colon cancer-related mortality (OR 0.85, 95% CI, 0.66–1.09, <i>P</i> = 0.20), rectal cancer-related mortality (OR 0.76, 95% CI, 0.53–1.11, <i>P</i> = 0.16), and overall mortality (OR 0.87, 95% CI, 0.73–1.73, <i>P</i> = 0.11) between the laparoscopic surgery and open surgery groups. The overall complications in the laparoscopic surgery group were much lower than that in the open surgery group (OR 0.71, 95% CI, 0.58–0.87, <i>P</i> = 0.001). This meta-analysis showed that the successful laparoscopic colorectal resection for colorectal cancer was as effective as open surgery in terms of the oncological outcomes, thereby suggesting that laparoscopic surgery can be continued in patients with colorectal cancer.</p></div></div></section> <div class="c-notes"> <p class="c-notes__text c-status-message--info"> <svg width="24" height="24" focusable="false" role="img" aria-hidden="true" class="c-status-message__icon"> <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-info-filled-medium"></use> </svg> This is a preview of subscription content, <a id="test-login-banner-link" href="//wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12032-010-9549-5%3Ferror%3Dcookies_not_supported%26code%3D6bd65465-36f9-4480-ae27-9e62a274353e" data-track="click" data-track-action="login" data-track-label="link" class="c-preview-message__link">log in via an institution</a> <svg width="16" 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srcset="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12032-010-9549-5/MediaObjects/12032_2010_9549_Fig5_HTML.gif?as=webp"><img src="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12032-010-9549-5/MediaObjects/12032_2010_9549_Fig5_HTML.gif" alt="" loading="lazy"></picture></div></div></figure></div> </div> <div data-test="cobranding-download"> </div> <section aria-labelledby="inline-recommendations" data-title="Inline Recommendations" class="c-article-recommendations" data-track-component="inline-recommendations"> <h3 class="c-article-recommendations-title" id="inline-recommendations">Similar content being viewed by others</h3> <div class="c-article-recommendations-list"> <div class="c-article-recommendations-list__item"> <article class="c-article-recommendations-card" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-article-recommendations-card__img"><img 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University, 600 Yishan Road, 200233, Shanghai, People’s Republic of China</p><p class="c-article-author-affiliation__authors-list">Yanlei Ma, Zhe Yang, Huanlong Qin & Yu Wang</p></li></ol><div class="u-js-hide u-hide-print" data-test="author-info"><span class="c-article__sub-heading">Authors</span><ol class="c-article-authors-search u-list-reset"><li id="auth-Yanlei-Ma-Aff1"><span class="c-article-authors-search__title u-h3 js-search-name">Yanlei Ma</span><div class="c-article-authors-search__list"><div class="c-article-authors-search__item c-article-authors-search__list-item--left"><a href="/search?dc.creator=Yanlei%20Ma" class="c-article-button" data-track="click" data-track-action="author link - publication" data-track-label="link" rel="nofollow">View author publications</a></div><div class="c-article-authors-search__item c-article-authors-search__list-item--right"><p class="search-in-title-js c-article-authors-search__text">You can also search for this author in <span 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class="c-bibliographic-information"><div class="c-bibliographic-information__column"><h3 class="c-article__sub-heading" id="citeas">Cite this article</h3><p class="c-bibliographic-information__citation">Ma, Y., Yang, Z., Qin, H. <i>et al.</i> A meta-analysis of laparoscopy compared with open colorectal resection for colorectal cancer. <i>Med Oncol</i> <b>28</b>, 925–933 (2011). https://doi.org/10.1007/s12032-010-9549-5</p><p class="c-bibliographic-information__download-citation u-hide-print"><a data-test="citation-link" data-track="click" data-track-action="download article citation" data-track-label="link" data-track-external="" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1007/s12032-010-9549-5?format=refman&flavour=citation">Download citation<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p><ul 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