<p class="MsoPlainText"> 白细胞介素<span>6</span>对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响<span></span>

<!DOCTYPE html> <html> <head> <META NAME="GENERATOR" CONTENT="北京玛格泰克科技发展有限公司"> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <Meta http-equiv="Content-Language" Content="zh-CN">  <meta name="citation_issn" content="0529-1356" /> <meta name="citation_journal_title" xml:lang="zh" content="解剖学报" /> <meta name="citation_journal_title" xml:lang="en" content="Acta Anatomica Sinica" /> <meta name="citation_language" content="zh" /> <meta name="citation_volume" content="54" /> <meta name="citation_issue" content="6" /> <meta name="citation_firstpage" content="722" /> <meta name="citation_id" content="54/6/722" /> <meta name="citation_doi" content="10.16098/j.issn.052-1356.2023.06.015" /> <meta name="citation_title" xml:lang="zh" content=" 白细胞介素6对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响 " /> <meta name="citation_title" xml:lang="en" content=" Effect of interleukin-6 on nucleated erythrocytes in lipopolysaccharide induced preeclampsia rats " /> <meta name="citation_authors" xml:lang="zh" content=" 刘丽平朱梦妮徐慧 " /> <meta name="citation_authors" xml:lang="en" content="LIU Li-ping ZHU Meng-ni XU Hui " /> <meta name="citation_publication_date" content="2023-12-06" /> <meta name="citation_online_date" content="2023-12-06" /> <meta name="citation_keywords" xml:lang="zh" content="子痫前期<span>" /> <meta name="citation_keywords" xml:lang="zh" content="</span>白细胞介素<span>6" /> <meta name="citation_keywords" xml:lang="zh" content="</span>有核红细胞<span>" /> <meta name="citation_keywords" xml:lang="zh" content="</span>白细胞介素<span>1B" /> <meta name="citation_keywords" xml:lang="zh" content="</span>免疫组织化学<span>" /> <meta name="citation_keywords" xml:lang="zh" content="</span>免疫荧光<span>" /> <meta name="citation_keywords" xml:lang="zh" content="</span>人<span>" /> <meta name="citation_keywords" xml:lang="zh" content="</span>大鼠" /> <meta name="citation_keywords" xml:lang="en" content="Preeclampsia" /> <meta name="citation_keywords" xml:lang="en" content="Interleukin 6" /> <meta name="citation_keywords" xml:lang="en" content="Nucleated erythrocyte" /> <meta name="citation_keywords" xml:lang="en" content="Interleukin 1B" /> <meta name="citation_keywords" xml:lang="en" content="Immunohistochemistry" /> <meta name="citation_keywords" xml:lang="en" content="Immunofluorescence" /> <meta name="citation_keywords" xml:lang="en" content="Human" /> <meta name="citation_keywords" xml:lang="en" content="Rat" /> <meta name="Description" xml:lang="zh" content=" 目的探讨白细胞介素(IL)-6对脂多糖(LPS)诱导..." /> <meta name="Description" xml:lang="en" content=" Objective To explore the effect of interleukin (IL)-6 on nucleated ..." /> <meta name="citation_abstract_html_url" xml:lang="zh" content="https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.052-1356.2023.06.015" /> <meta name="citation_abstract_html_url" xml:lang="en" content="https://jpxb.bjmu.edu.cn/EN/10.16098/j.issn.052-1356.2023.06.015" /> <meta name="citation_pdf_url" content="https://jpxb.bjmu.edu.cn/CN/article/downloadArticleFile.do?attachType=PDF&id=2648" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="zh" /> <meta name="DC.Title" content=" 白细胞介素6对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响 " /> <meta name="DC.Identifier" content="10.16098/j.issn.052-1356.2023.06.015" /> <meta name="DC.Contributor" content="刘丽平" /> <meta name="DC.Contributor" content="徐慧" /> <meta name="DC.Contributor" content="朱梦妮" /> <meta name="DC.Date" content="2023-12-06" /> <meta name="DC.Keywords" xml:lang="zh" content="子痫前期<span>,</span>白细胞介素<span>6,</span>有核红细胞<span>,</span>白细胞介素<span>1B,</span>免疫组织化学<span>,</span>免疫荧光<span>,</span>人<span>,</span>大鼠,"/> <meta name="DC.Keywords" xml:lang="en" content="Preeclampsia,Interleukin 6,Nucleated erythrocyte,Interleukin 1B,Immunohistochemistry,Immunofluorescence,Human,Rat,"/> <meta name="robots" content="index" /> <title><p class="MsoPlainText"> 白细胞介素<span>6</span>对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响<span></span> </title>  <link href="https://jpxb.bjmu.edu.cn/js/bootstrap/css/bootstrap.min.css" rel="stylesheet"> <link rel="stylesheet" href="https://jpxb.bjmu.edu.cn/images/0529-1356/css/css.css"> <link href="https://jpxb.bjmu.edu.cn/js/bootstrap/css/font-awesome.min.css" rel="stylesheet">  <script src="https://jpxb.bjmu.edu.cn/js/jquery/jquery.min.js"></script> <script src="https://jpxb.bjmu.edu.cn/js/bootstrap/js/bootstrap.min.js"></script>   <link rel="stylesheet" href="https://jpxb.bjmu.edu.cn/js/colorbox/colorbox.css"> <script src="https://jpxb.bjmu.edu.cn/js/colorbox/jquery.colorbox.js"></script> <script type="text/javascript"> //等比缩放图片 function DrawImage(ImgD,FitWidth,FitHeight){ var image=new Image(); 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Department of Obstetrics of the Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan430015, China;  <p class="MsoPlainText">  2.Department of Obstetrics of Wuhan Children’<span>s Hospital</span>（<span>Wuhan Maternal and Child Healthcare Hospital</span>）<span>, </span> Tongji Medical College，<span>Huazhong University of Science and Technology, Wuhan 430015, China</span></li> </ol> </address> <ul class="list-unstyled code-style" style="overflow: hidden;"> <li> <span> <code>Received:</code>2022-07-21 </span> <span> <code>Revised:</code>2023-02-09 </span> <span> </span> <span> <code>Online:</code>2023-12-06 </span> <span> <code>Published:</code>2023-12-06 </span> </li> <li> <code>Contact:</code> Hui XU E-mail:xuhui@zgwhfe.com </li> <li> </li> <li> </li> </ul> </div>   <div class="group clearfix"> <div class="row diyihangdg"> <div class="col-xs-6 col-sm-4 col-md-2 col-lg-2 margin-bottom-10"> <span class="change-section"> <a href="#1" onClick="lsdy1('PDF','2648','https://jpxb.bjmu.edu.cn','2023','114');return false;" class="black-bg btn-menu"> <i class="fa fa-file-pdf-o text-danger"></i> <h2>PDF</h2> <span class="badge"> <span id="mag-getXiaZaiShu-2648"></span> <script> $("#mag-getXiaZaiShu-2648").load('/CN/article/getXiaZaiShu.jsp?articleid=2648&ajax=true'); </script> </span> </a> </span> </div>  <div class="col-xs-6 col-sm-4 col-md-2 col-lg-2 margin-bottom-10" id="knowledge_map_div" style="display:none;"> <span class="change-section" onmouseover="changeKnowledgeMapImg(2)" onmouseout="changeKnowledgeMapImg(1)"> <a href="../lexeme/showArticleByLexeme.do?articleID=2648" class="black-bg btn-menu"> <i class="fa text-muted"><img src="../../images/knowledge_map1.png" height="40" style="margin:0px;" width="36" id="knowledge_map_img"></i> <h2>可视化</h2> <span class="badge" id="knowledge_map_count">0</span> </a> </span> </div> </div>  </div>  </div> </div> </div> <div class="row" id="pin"> <div class="col-lg-11 col-md-10 col-sm-12 col-sm-12">  <div class="panel-group" id="accordion" role="tablist" aria-multiselectable="true"> <div class="panel panel-default"> <div class="panel-heading" role="tab" id="zhaiyao" onClick="xianshi(this)" style="cursor: pointer;"> <h4 class="panel-title"> <a id="abstract"> 摘要/Abstract </a> </h4> </div> <div id="collapseOne" class="panel-collapse collapse" role="tabpanel" aria-labelledby="headingOne" name="#abstract" style="display:block;"> <div class="panel-body line-height text-justify"> <p><strong>摘要： </strong><p class="MsoPlainText"> 目的探讨白细胞介素<span>(IL)-6</span>对脂多糖<span>(LPS)</span>诱导类子痫前期大鼠有核红细胞的影响。  方法采用ELISA和免疫组织化学法检测正常妊娠、轻和重度子痫前期患者外周血与胎盘中IL-6的表达；采用流式细胞术和免疫荧光法检测母体有核红细胞比例。SD妊娠大鼠随机分为3组：对照组、LPS组和LPS+anti-IL-6组，检测外周血和胎盘中IL-6、有核红细胞比例、JAK2/MEK和PI3K/Akt信号基因表达。  结果子痫前期患者的IL-6明显高于正常妊娠者。相比于对照组，LPS组外周血和胎盘中IL-6、有核红细胞比例和JAK2、P85、Akt、P65、IL1B mRNA表达明显增加，胎鼠体重明显降低；相比于LPS组，LPS+anti-IL-6组外周血和胎盘中IL-6表达、有核红细胞比例、JAK2、P85、Akt、P65和IL-1B mRNA表达明显减少。  结论子痫前期患者外周血和胎盘IL-6上调伴随外周血有核红细胞增多，在体中和IL-6可能通过下调有核红细胞JAK2/PI3K/Akt/NF-κB信号介导的IL-1B表达从而保护类子痫前期大鼠。 </p></p> <form name="refForm" action="showCorrelativeArticle.do" method=post target=_blank> <input type="hidden" name="searchSQL" value="" /> <input type=hidden name="keyword" value="" id="keyword"> <input type=hidden name="author" value="" id="author"> <p><strong>关键词: </strong> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','子痫前期<span>')">子痫前期<span>, </a> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','</span>白细胞介素<span>6')"></span>白细胞介素<span>6, </a> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','</span>有核红细胞<span>')"></span>有核红细胞<span>, </a> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','</span>白细胞介素<span>1B')"></span>白细胞介素<span>1B, </a> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','</span>免疫组织化学<span>')"></span>免疫组织化学<span>, </a> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','</span>免疫荧光<span>')"></span>免疫荧光<span>, </a> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','</span>人<span>')"></span>人<span>, </a> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','</span>大鼠')"></span>大鼠</a> </p> <p><strong>Abstract: </strong><p class="MsoPlainText"> Objective To explore the effect of interleukin (IL)-6 on nucleated erythrocytes in lipopolysaccharide (LPS)-induced preeclampsia rats.  Methods ELISA and immunohistochemistry were used to detect the IL-6 in peripheral blood and placenta of preeclampsia and normal pregnancy; Flow cytometry and immunofluorescence were used to detect the maternal nucleated erythrocytes. Pregnant SD rats were randomly divided into 3 groups: the control, LPS and LPS +anti-IL-6 group; IL-6, the proportion of nucleated erythrocytes, JAK2/MEK and PI3K/Akt signal-related genes were detected.  Results The IL-6 of preeclampsia was higher than that of normal patients. Compared with the Control group, IL-6, the proportion of nucleated erythrocytes and JAK2, P85, Akt, P65, IL-1B mRNA of LPS group increased, the fetal weight decreased; Compared with the LPS group, IL-6, the proportion of nucleated erythrocytes and JAK2, P85, Akt, P65 and IL-1B mRNA of the LPS+anti-IL-6 group decreased.   Conclusion The up-regulation of IL-6 of preeclampsia patients is accompanied by increased nucleated erythrocytes in peripheral blood. Neutralizing IL-6 in vivo may down-regulate JAK2/PI3K/Akt/NF-κB-signal-mediated IL-1B to protect preeclampsia rats. </p></p> <p><strong>Key words: </strong> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Preeclampsia')">Preeclampsia, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Interleukin 6')">Interleukin 6, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Nucleated erythrocyte')">Nucleated erythrocyte, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Interleukin 1B')">Interleukin 1B, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Immunohistochemistry')">Immunohistochemistry, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Immunofluorescence')">Immunofluorescence, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Human')">Human, </a> <a href="#" onClick="searchEnKeyword('https://jpxb.bjmu.edu.cn','1','Rat')">Rat</a> </p> </form>  <form name="subjectSchemeForm" action="" method=post target=_blank> <input type="hidden" name="searchSQL" /> <input type="hidden" name="language" /> </form>  <p> <strong> 中图分类号:  </strong> </p> <ul class="list-unstyled pacs"> <li> <p> <a href="#" onclick="subjectScheme('https://jpxb.bjmu.edu.cn','R285.5&nbsp','1');return false;" target="_blank"> R285.5&nbsp </a> </p> </li> </ul>  <div class="row hidden-xs hidden-sm"> <div class="col-xs-12 col-sm-2 col-md-2 col-lg-2 margin-bottom-10 text-center"> <div class="text-primary btn-menu"> <h4>引用本文</h4> </div> </div> <div class="col-xs-12 col-sm-10 col-md-10 col-lg-10 margin-bottom-10"> <div class="primary-border"> <p> 刘丽平朱梦妮徐慧 . <p class="MsoPlainText"> 白细胞介素<span>6</span>对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响<span></span> [J]. 解剖学报, 2023, 54(6): 722-729. </p> <p>LIU Li-ping ZHU Meng-ni XU Hui . <p class="MsoPlainText"> Effect of interleukin-6 on nucleated erythrocytes in lipopolysaccharide induced preeclampsia rats [J]. Acta Anatomica Sinica, 2023, 54(6): 722-729.</p> </div> </div> </div> <div class="row hidden-xs hidden-sm"> <div class="col-xs-12 col-sm-2 col-md-2 col-lg-2 margin-bottom-10 text-center"> <div class="btn-menu bs-callout-warning"> <h4>使用本文</h4> </div> </div> <div class="col-xs-12 col-sm-10 col-md-10 col-lg-10 margin-bottom-10"> <div class="primary-border"> <p> <b> <form name=mail action="https://jpxb.bjmu.edu.cn/CN/article/sendMail.jsp" method=post target=_blank> <div class="bshare-custom pull-left"><div class="bsPromo bsPromo2"></div><a title="分享到微信" class="bshare-weixin" href="javascript:void(0);"></a><a title="分享到新浪微博" class="bshare-sinaminiblog" href="javascript:void(0);"></a><a title="分享到QQ空间" class="bshare-qzone"></a><a title="分享到腾讯微博" class="bshare-qqmb"></a><a title="更多平台" class="bshare-more bshare-more-icon more-style-addthis"></a><span class="BSHARE_COUNT bshare-share-count" style="float: none;">0</span></div><script type="text/javascript" charset="utf-8" src="https://static.bshare.cn/b/buttonLite.js#style=-1&uuid=&pophcol=2&lang=zh"></script><script type="text/javascript" charset="utf-8" src="https://static.bshare.cn/b/bshareC0.js"></script>     /   <a href="#" id="collectArticle" class="shouc"></a> <span id="collectCount"></span> /   <a onclick="mail.submit()" href="javascript:void(null)" class="tuij">推荐</a> <input type="hidden" value='我在《解剖学报》上发现了关于“<p class="MsoPlainText"> 白细胞介素<span>6</span>对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响<span></span> ”的文章，特向您推荐。请打开下面的网址：https://jpxb.bjmu.edu.cn/CN/abstract/abstract2648.shtml' name="neirong"> <input type="hidden" name="thishref" value="https://jpxb.bjmu.edu.cn/CN/abstract/abstract2648.shtml"> <input type="hidden" name="jname" value="解剖学报"> <input type="hidden" name="title" value='<p class="MsoPlainText"> 白细胞介素<span>6</span>对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响<span></span> '> <form> </b> </p> <p><b>导出引用管理器</b> <span class="daochu"><a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=EndNote&id=2648" id="ris_export">EndNote</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=Ris&id=2648">Reference Manager</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=ProCite&id=2648">ProCite</a>|<a id="bibtex_export" href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=BibTeX&id=2648">BibTeX</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=RefWorks&id=2648">RefWorks</a></span> </p> <p><strong>链接本文:</strong> <a href="https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.052-1356.2023.06.015" class="txt_zhaiyao1">https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.052-1356.2023.06.015</a> </p> <p> <strong> </strong>              <a href="https://jpxb.bjmu.edu.cn/CN/Y2023/V54/I6/722" class="txt_zhaiyao1"> https://jpxb.bjmu.edu.cn/CN/Y2023/V54/I6/722</a> </p> </div> </div> </div> </div> </div> </div> <div class="panel panel-default" > <div class="panel-heading" role="tab" id="cankaowenxian" onClick="xianshi(this)"> <a name="reference"></a> <h4 class="panel-title"> <a id="reference" class="collapsed" href="javascript:;"> 参考文献 </a> </h4> </div> <div id="collapseThree" class="panel-collapse collapse" role="tabpanel" aria-labelledby="headingThree" style="display: none;"> <div class="panel-body">  <table width="98%" border="0" align="center" cellpadding="0" cellspacing="8"> <tr> <td class="J_author"> <p class="MsoPlainText"> ［<span>1</span>］<span>Ives CW, Sinkey R, Rajapreyar I, et al. 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