CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "onlinelibrary.wiley.com",cType: 'managed',cRay: '90f9754edade9fdd',cH: '1VBwPTdj06coNMMwdpR4lZ_seTYqiEsMts3XiEBFUCY-1739162815-1.2.1.1-toRycl.WI8sJRNox3wmzTDSlIamfnAeiiAK9kyiIUoq9gu7o.SaILMIlyTQD5n5I',cUPMDTk: "\/doi\/10.1097\/01.mlg.0000149463.95950.c5\/full?__cf_chl_tk=D10yW9VJhs__buguZXgMohFywD9AwQuBs2A5X2A1sT4-1739162815-1.0.1.1-t4lnxQCIF4UUtj8Hc0eufwXU7wGw_aSFUAeTnMx1fSQ",cFPWv: 'g',cITimeS: '1739162815',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1097\/01.mlg.0000149463.95950.c5\/full?__cf_chl_f_tk=D10yW9VJhs__buguZXgMohFywD9AwQuBs2A5X2A1sT4-1739162815-1.0.1.1-t4lnxQCIF4UUtj8Hc0eufwXU7wGw_aSFUAeTnMx1fSQ",md: "dxglm9CwdyatZ51Zf.Mj3KmQ9CwEOt9kASvg0mLrDvI-1739162815-1.2.1.1-pe6c0kV8pBqjJYQBzlzi5SQlZ4DzNUgRT_xEeYJfhzlzhaNRPdS46ioiegu9NwC7FdasIXBbtPVmd7iDHvbZwWG7BenEgfESz5n89IM2ctMSruQ44qYHvpq5ihKNJjnVcU8zTz37NSpmnvZN77rPX0.9uzfB0.TOAc1L2WudguW2j_L6A84KHVp7Lz2sPxGBg_VS9CBrkgJk8dd1GBVCXOY.Pjto4YdcP2ormItyul77simix0L5edhKlpf2CS8EKEzk68MBZpRv0gojHpbXYp.LDv0hkWYRcNMKjnx9ljCQ8LejgLFlvAMldSup6JuTE.hT7uTGl0oE_C4mhspce.pYrHYqoxE46R4mAI9TPy7TnV1Dzju2vT8iCxHgkvLXsgUDFIbPucrviS1iCS5BfbqeDqZtCw23FbQ4SGe8YRSYyt4d3qAr_0.joqC7bcVoR43KbcrUa_OqZikr_7YUZd1rITGLO7oiMp1LKjhpMsXw1sZ_f4SBhd1xCajWXn_.uTOzi8n4KKKWjRSi5gTG3rwgv8aKvSFrhPrSiN79EZqweF1Akb_EFJXODxq8x2iYwqX5j3d_sLqeLW.dqjFIkRdvZgjqjAD5y7XxqHn1YWIXeXaDniHUS7t1PaEypCxWasRkjNkKT6Sfzo2BccZX4Nn9qMCu_TkKqFfk3Oon7koib5tpMmInxcEyuUN30Dhe3agwJ82J37d.3RJ3JCbdA43MMQy9pPfXmEJ1q8tgeiq3ezeHv6GsDbHebIHjXu_XRzzp.b_iKld.cMdyAfKcnlVtdHYFA.le76wC6Wvymy2IjrEtyFAn9hOgPAJwQMegDx.NnhbRDYCZB.XLiQDZ0iKonXJA29HudRyOcpK_oGy0Vc75P6gU9MH67ZCWS0KeuWyaYbh.N8ahjfIjc9l8LAMWLuuG2YTxFZk7yvzfFNWqoy94UOj4t7QnWRSX27_2aM8tNe9G..vzUse.wxJFPKEv268qrt2GXLuq.suFMbaszyEIlGkOWy58AzznU9L2xQk789iAzUzx_AC1GXYrDxq__64DTPPVC1Ng7Y3U8vEhSYQ6X33k6_5mYdD567F0qqBaJ3dpJZ9dMpcZND5AXdIkiRcLn96sTEOwnljvb3UZdLZhaz4E7m_qoC0cNYO3AtNolRaOXVfVq_1KuPUDA2LYN7xPuuU6KVaTUINb_Vy4aTWQ4N1IGwMZL8YwtijMTOqVPY01uzt6yna3oldfymqYa0lDlkCr8nMrgQMRsfvu0Vu2PkuGClgRJo2QtUADma1Hhr1UfPn4xag4i7brefXpFUmQXTbPveKW2rlugar8vC6JHZGKgjzg5U7YJHsUkjw7EAOCLVznAiJ9hoffzqYMhToZkOB2hu8DK2bAw5CgczjHA5LMFsVqDmT6i1ryULkdIA8Zlhwl.Ie5EKZYyMTWrOCGu7O7km0gv7f8DFz9yGmpy4_teQZGjHYh8kNDP0hDrC.lV3QLfIydu3c4Q8HNKXCcJhLldVH6JBHL8iDgCG0pTVNxMV5vItRGVzOMGpGl0.Rjxl0dsUaSYEkE_7bv6Yxt_DGuZXK2Wn1lzDMz7ODZYkjnO0XqbfGIy.cR50f_h160Fc2m62J5Tvwjt0lvfxhEeR39OlYWq2dQS_hgX5Z0HIJQ0GYiqUXddBBfiVdJyWUZApwevNHCcqCkwnroRsRQKdlnkFjgdGa8z_ziQGT_xV3fgZlM_weTsOM4y3aTDxgTpv0lF8KYG62cVrUgfREVwj4VZBJaYSUmrvSAuNSdMfl3JgaaNDjOojQHD15GfyeUH5xwhKmdD_CpawISP91CkY2wP3Ad7TQi455quP6fK8PmuNUVFeaahnagggwYW_htky5w0Vxr6EfJBjx0LAB.EvlezUTv78s332cL5exlueoA2HGQtgmc9Coo2pxDUWjK7VD3uVZ06BRyO2n0ekI_GWFfJONFU.o5g8XaWQYitrOl2NpvAFfZJEiKPkQjtuAFXz6F9UTN4u726unjXN0W41sldOMvp2O_tnZw83SBsmlP83tld8u_QHGEKOAoiN_x19DIsqK9BhTQFDYFc2I0tKaUPSVTBxjSGXqxlgq_fkQMmSMD1Yc0i5WzPwhMFlu0fxwgx8Vn_GlTq6xMmaH6lYRLsLyxWPdemWCt1du_WLqsk3bdSRqHY30GA3m.mdlbnXctYt6kBcjX2tfC1FYk3Ukl9UZ0mGHxeEFPmApHgGWVxf9E8R_xBsb72oAHtN2FEVXquadw1BFdIVTgbWcOxvpUBMCtn8eLuaVrK.OM7HTM6BmCo6o1uRUxChw_LdwrapxIFeXsyUGAP1h_a0_dPE3sPU_bhpeDrxy5MVoGSThm8vnWcjTFt8lSGph6RTNF4pofPv6ekee.fQQbzQRXY5cS813W0vJIqBzSGQnymsIPO9MsYRfco6sWQuz9z2TZeN3.oqjKR7s54iduZ_1yz3Ov2tGZoMmWIqJ.Po85BI78Q_hoWczbDewL7Wy3dNvpfG6NGWH_uyZy0HuwDLLO9M4bDVKyagfzl9pgQbBIYUfloBJ7goqOt.3SC0DB3MYB7gYI72lUdA6r1adiqVnT6g7fEoYDao0Sw9b5k9Yud.h7P8TB06jnOaEdWsyU3aLmhlN0o4CtdB6o5Q",mdrd: "kKdjG4QTyYAa.T8tI_WVFQtVm77x_N1J._V.rukqu64-1739162815-1.2.1.1-p4rTwVcar0_LQCOUDEY2s6KgYRfx79oBdo.pOHE7ymEzKZmWg80y9ZOBksAp0gwcrcvfTr3aoweueQqiVWztA2O_YoYLnGXpBcflCA_KZ8yykkKH4SjHU2Eh8C3BYQFrF2i6ck.3ZX_B22QHsnDj3DuCBdlnReXkb4z2dve.Msqhy79TiES4C2hB1NZBfpHxD4L0MpN7mkTTDsLIPAabIOlFsemLkyMOSxiaXPXBm.HHBkvilqtIWbfS_btRXHXzfSq.naM9Pzl3ICCLoRz5miQPu_tsvyb1dyXqjECIIWxBdyERUPe1j1rYIPB5TOTzTIfEjCuGH9IHVTpvWjP2MV0so3FdX9uQS_5aeP9RiXCMLx1UO87GFCT.9bSCdBkzpfH60W8nVyQFSrG9aqMVPNW6RjwbjyxsmuNdUAMW5z2uDh8ETxWEgvFR0CYb375mbpcGtMIwM_0NtuZa6e7sGB_FEET.tT30EO0qpmLgfC3727YuYxY5OXo6EpIYDgqxmamnusVt5.mWWb2HqZSjuIlTcfR8n1P_ZI2KmR9.A8FvZEIkDkMNaA0kFeLp_RdRsl4ve51IUQmIicWzWU4dVNfIrrqbJIiyt41P8aHaCwwF0UIR2qB9Mck0OpflNiw7bVzGTpdv9PFw2BcpycnZmF.pf4d7wpHm3F6R1BsYNA6TRA4ghstDz1UK7gJF8ubUEZShnDJBX0kV4huozWjtws8wRUaK981b.o4_vGmfPywHUlpgpE7Bl2JWiqrEez5n9RMPh5dWD38QanCBFABvY_qwX4YCvNxHCYewx0CwNliLrfUhBgVPuoqfvLHQ8GsUlumckDN6Fm1iN2AZPoCwVv9NDl9UyTwBLW9mtTC7HCTQyM5O.HKkDRpaRGUxSHGlkfl9aadckENWX0YFwKzVV830NmlcyShttFSJ0q9LF9k_2GMekK3IAJ3ZDHwHXf0e7Oo0A9uMupSzHC16EKCOwYXR.Vjl.uOkH97WVqCTqV5_Z9rrk6p6xlIbEyQ7MYbd0SVHEp2YV5V0g0BBxIO3wQxBEjJ7kRWPNrNE8noINIsdkuB6GjbWsyzemZxcEqqdET8c.IgtHxzaP.0CRe6OH32zDKokZkQvD.DwxKbd86zwoqGKn5Hy7l3UXTr2ZYwhy.Y7E8MUn9bCZNXkFujxsuaBDc4ibsoNQsxXidxLE6x1BslfAW4gmnnd.UX.rcxQT03stpGM1GG1JkTxI.tPsnmag5VBy7UgLwBcqjYbVghImJfjE9uMT_OiWXIySzhjEdTQgw7OPwfK5ZRJOcP9LEBcWz9Wro2OStdW4oIaK2.wL6JMYRHKLpjfC8p5jgyTKi3UkO3jvf.t33wySWXnrsdYcnceo1tHSYwUaSxOCJ65HaFPUzvCx7OK4hnFj229RW8Lp4u6LpcbLli2LnzcW_QHbpgf7XdnFzXR0eD1D2_ZwBs4UK1KHNwMtxJ5qrh7NIojsuUrzrZNCBLZyjw8G5ZftRRRgpxluU2PRJ5GUgWej4bpDs.fkUACq4_.aowU8hmi_IsHE1sH4IL23F2Il8oXkfTh6tVJYLllwYbqi.FyxnkbiTn.d1_43Mpwgue4goXwyiqaELUZ8WJPIrTa4x6bvvqqPeG14n8mVuHCS9k7RKzr4sBp3pwiCU6vzEdHyDd2eB_1xkh4LEvizOlAcDw5Ho2nqKtt4lFtbbOUtHqsNwRgLk2r.Syn2BZRbHp8R9yh2MgGIX..Zo2GiHLkB9_hkhHBfvlrhjqJcCdWMb.0EaFT2uZVqXZzji3LzT_fYzfpbRPEOctRKdyzw6PjJ6kg7jHgTyT395syYpbH0MjAJusuKRsBI8JKzsT9EmbnO8ggBFiz8ctvFBg2sNrLHAxVCOa9o6KG3tkYv9lpH1_K9vh6H4fMcjLodesrTmRpAKYcwK76.FuSw5.e5UD4vNJ7kG3L7fTPatYTdWzfdpYJrTTYONsxS.0MGhKtbcGqbPnqrHIZAypGliLElFgdiw"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=90f9754edade9fdd';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1097\/01.mlg.0000149463.95950.c5\/full?__cf_chl_rt_tk=D10yW9VJhs__buguZXgMohFywD9AwQuBs2A5X2A1sT4-1739162815-1.0.1.1-t4lnxQCIF4UUtj8Hc0eufwXU7wGw_aSFUAeTnMx1fSQ" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>