CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "bpspubs.onlinelibrary.wiley.com",cType: 'managed',cRay: '91c68a468e344d21',cH: 'Pu_ATjjv.MxjpI9gd90AhCX.4p_3QrZpL6Tf3QewA5s-1741313255-1.2.1.1-Lpe4fun6U_fsd78N3n5am8wzpT2ymps6UClUUED8.UmNIALE4iEIQWfbDa5SDGq5',cUPMDTk: "\/doi\/10.1038\/sj.bjp.0707332?__cf_chl_tk=Yv.shTFw4XqxuZw.s6wSUYRKDluZw2buSw2mxDmmiiY-1741313255-1.0.1.1-QUh2TYTuoPEE4GwEAu1kOBrR1F32a7wO0u9TEjXbGiI",cFPWv: 'g',cITimeS: '1741313255',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1038\/sj.bjp.0707332?__cf_chl_f_tk=Yv.shTFw4XqxuZw.s6wSUYRKDluZw2buSw2mxDmmiiY-1741313255-1.0.1.1-QUh2TYTuoPEE4GwEAu1kOBrR1F32a7wO0u9TEjXbGiI",md: "vUu9GiGHj1dT1ztS9glk_V0bvKDg67ybUUov8BqXQog-1741313255-1.2.1.1-y2fuD50fn2CZ7EcCtl1dVWOXax1K4BfecJnUUCaJMrBh0p5UP0ybblwfSpXmReXPGwbafuqitjOUIhZyJNJC2Yxqf0mka96tbGY9691MQ94Fa6Cl1.YwdxSyd4fV_n0BfxJU1x4XdiwVnNaH0agCGuBoUJU1exZumNDS1oCDQvZQw2NVn_zYOqsDGDfzqsb7i7HPPR235bQRLDNGRaliGtDmPKKtgKvnN5NtoFtvnGDoe0xj5.u3Ixsh0LU514cWmQQywaphywr2YgiP2fDI1tO0TxuebSZiSqggZ6DJkjAZcScOIGPLfhXEHrHBIvZyvbTD_vAimhVjFb9ZlU53K8DU3uATZIIo7uRmchos7oO4QcXdB62Ixj_CmIoitx7bhHsEwvBoha3witosXqsYI2PWBlvCjf7UjHqldzGoeGzbDy2GN_d6lyUHmOQLaTgZS43sHKWG35sKdVGJxuUse8vibLhMFXyr1Lx38FZrB3RqRnvjAgeAwMhZ76kxnYps2CCpl8gfiSHFehieN4ubrxN43AHSgxfgwJDslwcdiH_qXXNouFp81YKT93LFJ9Ztm18TtCQQ.Ossi4C.Hq6mpPUAhfOY5AuQ._2DNtWDHdhEpO9U.CwrK06HXphiaJXsro9AGLxVWbPhri2MNP3CpktdZCpx4uIlr9SKKXQ1Xq0Fy4hMuk_u1jHunltt2SkYw4zsR3zEzFpumr9pV5myqjD7ESYgzvLXuEUavCeCnLd95fYLTdnywSaOgbpiXwyfew3g13w9LPlgPAJfDuR.Gq9f2Of9ri.NXgA9KF4VGTtUeqXaznCP_1qxxIE0lWVzgafMrJO77XiEl2w2sLvq4JV59a0LyKq2yapTYhsRCh8GWcKN0dZfdcw7w9eRIqkemVUM2qIs6J.UWPX0Acxy.aPCERgL.DlAnS15i1GD2MavH.TwtQprYkn8pf1oOjDIxHMKb6HyBQts8fy4szAdU1YFC6vmZ91SugI6AXzSj9wK.UISnQDZoNcaKTgiaIUHfqwbrsT7YcmmvuwS9O_XrOPaj6_yQ7ik42VhZ1gzCnX4sNpp_u4VOg5yemQ5uD0JeiOb1XloxOEWO_D.7ivjv.ISsmEQHSqY66hy_5_KmqOYyLUZNiZBc3vMPrTxN0JDnspBu5.aiacDa7eqkg7H7qmTUEcca3Me1qdAVINsMj6fcSvV4_ITXy1sMZahCiqWDTloqpZGoCVD4TKXn5iwkHEEppp3wA_TwqJ5RpNREvhFpO57AeOPhuNyPnERrTNFsG3Q6itxiPejZYh97VjViHx4eFYeEFj8J8tOaUpDHfY",mdrd: "NMOCaoAMxvrTbB5rFmd4TE.CBmGvrClWhccr_6UBDVw-1741313255-1.2.1.1-muDVOCx1Ok6aFiS.v4d6aAENDHd4o6647McNnJ14WGPoH4YAnpWjueUmdGPRF2Qx6p8h3AOFPXwSrUZv.o66bAXBzPYbCW._BimehmIEpzC6pLzxs.WSGHePLTrsvZNsimk1yRBb.h3y8TJ34xvtzaXuyvTDia_Hx1t4DzUkxGaJACEB8.SCF1O8J4W51o0.1fOnCK1AiP0EIqlBJ38.qDyHcDspGXedusXP71Cbt55kBZtT84w37AFA9OOE84RlwH0vB7_ykl1GzL9dxeJKzDyvZSqIEUB175ZGwKO7ku6oZb0OkRZlXTwA4SmWKdjLISQrFR8_cvNzGaJmHSVFBq4JfESgMeHZvlwBx7wDB6zEMjdlfg8Gj1tb1nSHo2YUhSJ_gJ4dvGI6T2liEVuG.CnCkU8vkYwWJdbWzQn.mNirNAO4l5JW0MUglajU0IAEAb7h4i4HzkuokY5V.AT58xEqM2T6KidGcwYtBbu01Z_emQHxpKzFQ3eXthg2PASKm9OQ3dUW2erkRhA3u0TqmvvTvAWiKCgYQUDL50jRjBaOZPqFaEtMTem1sR63i911I35BW.nYHVG9YcuoJTp7KUe51bC3uBsoX4vGxbpjk5mn3y3CuGdUliqOMw344kirgFn1WBmOBHMPPo_TbjTru1omZzDk3hyHjAfFgivZD.oohhQTsEAJgcJB2TWuozfuyVAKlvSnkGOgGxGludyTnhRZFLYBQzIqzx1YWpnETqPxo4z0s83A.OD31_Mh7W4EN5zFQVjZtS_Y_xazS0Z3tnWrfOkUhGsndZvk8jFBUHv8iBBNi8JrVDW_cDE7xFgUQ.KaPX75PySdxMcxyOUoC7JmykJbRJPRuGNkcsFY9CjjI0S1KjEgrU0yQA2zSoBq47Fu0OHyoovi_lPl.npGRis9RmCUu1Af8MLHLurrIZxEDL16ZhYF4SZytIYCK29rxXbQ5Au8iGWo6v3RnycOewMWyhC7MLIwVAeHsJUS2DEUjXy5V0.wsbDqxNx1JAn5E3PUF1DzuG5nj9psCUSUk_IcO3PcA35hXIiuttgDSO2DeyLGAhbaCCT3qwZSyv4bJbrcivyQW7VgFb3bGWLHxLPZeOKpt82RLF9Je7QT.3.P3edkRsB8QO8bEbMSh_mP5Nc2ekSYuVJ91ZXpn2xO8M909rUNP7mX1FoP94D.LB.vEY7WmpAP_dpEjobNfGzz3GNwmzXEamsopU.PIDYE0X9PrevDNmgz8D5RMJ9qLP5_NXQXY1igyU4CzSZ0CK9hlrn1DRDRf7We9z1Sy3QodkBN9YOF3LAoRE9mYoFnPTfwzOAItVdwnVIffRPn8N4FQZz1Xq4fY_u2yplvx8.dpdwlm5JblBwNqH0nhq6qAFdcgrLTW7VeeVix2HH_mzYXChOndqBae7B_EGQRilkTxnSh8Zh.N5ND0oGp.iS9dyLEMgr3GmJD7Js8pjhF39.tV1uqTCr4uUluePLp9Ctx30P6Np84mP_s65BcMfhqXzCji67l4JBKBUSKrgWh13HBoAENToU12nbictgpBdzp5DHoyQpinoiFZZPPWEYg0PE_bOMJTiZgbIkIDBcfojrP8MtxV9c1cYf6hTAeyycA6dTes4N9_jvvMdSQ8XlqrvP_ke3vXJMSVRYRxobXN_fJPRQGSawqG87s_DNoTlcvxM0Fm4FK2gTg8Enk95rLX5VtNIIvD.wliR_QtzHzaR7FsOstViRbGSpbikZKNQjYsQXA5TmsZOe3ADR1Fp33uvFqKM3e6g_iRVfJAT3YWh1VBpCDS76VgWk2sz6geFQdP7eQlpVg29pRozVW6LDgcWSAsIMBdm5mPYs99WN7cC3AS8odf1cHgSHp.L9M4C505drz7LtvJC_vaZYJ6mUp5iVbQC9XSOxTT2V0bHAbOz7ZJcqNCu803U5YWxCwtIk.GCIB9UrAbJ07NrFJZeq5diQdeaTRoEA95j61Jl0KpHJN6FkJk2gthpnzZwWw8.fnAE2em5C.C3jDuP3hLV.TVoI"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=91c68a468e344d21';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1038\/sj.bjp.0707332?__cf_chl_rt_tk=Yv.shTFw4XqxuZw.s6wSUYRKDluZw2buSw2mxDmmiiY-1741313255-1.0.1.1-QUh2TYTuoPEE4GwEAu1kOBrR1F32a7wO0u9TEjXbGiI" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>