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Genome Sciences Centre

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content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--front has-carousel page"> <div class="region__header--inner region--inner"> <nav role="navigation" aria-labelledby="block-utility-menu" id="block-utility"> <h2 class="visually-hidden" id="block-utility-menu">Utility</h2> <ul class="menu"> <li class="menu-item"> <a href="https://www.bccrc.ca/dept/cid" target="_blank"><span class="nomobile">For Patients - </span>Find a Clinical Trial</a> </li> </ul> </nav> <section class="views-element-container block block--views-blockcarousel-block-1 block-views-block-carousel-block-1" id="block-views-block-carousel-block-1"> <div><div class="js-view-dom-id-bbeda3ba6ede53f0e079030346db8d4931e39bdee0487e4eb00ed20c71649961 view view--carousel"> <div class="views-row"><div class="views-field views-field-field-carousel"><div class="field-content"><div class="field field--carousel carousel" data-timeout="5000" data-slides=".layout__carousel_slide"> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_38 tinted" id="paragraph--38"> <div class="inner"> <h2 class="section__title">Canada&#039;s Michael Smith</h2> <h2 class="section__title">Genome Sciences Centre</h2> <div class="field field--summary"> <p>Excellence in genomics, proteomics and bioinformatics for precision medicine.</p> <p><a href="https://www.bcgsc.ca/about-us">About Us</a></p> </div> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_741 tinted" id="paragraph--741"> <div class="inner"> <h2 class="section__title">Canada&#039;s Michael Smith</h2> <h2 class="section__title">Genome Sciences Centre</h2> <div class="field field--summary"> <p>From Nobel roots.</p> <p><a href="https://www.bcgsc.ca/about-us/our-story">Our Story</a></p> </div> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_237 tinted" id="paragraph--237"> <div class="inner"> <h2 class="section__title">Canada&#039;s Michael Smith</h2> <h2 class="section__title">Genome Sciences Centre</h2> <div class="field field--summary"> <p>Developing new strategies to prevent, diagnose and treat cancers and other diseases.</p> <p><a href="https://www.bcgsc.ca/services/clinical-services">Clinical Services</a></p> </div> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_203 tinted" id="paragraph--203"> <div class="inner"> <h2 class="section__title">Canada&#039;s Michael Smith</h2> <h2 class="section__title">Genome Sciences Centre</h2> <div class="field field--summary"> <p>Expert assistance with experimental design and biotechnology development.</p> <p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="135724e3-2362-4712-8cc4-63f4ef7b0062" href="https://www.bcgsc.ca/services" title="Collaborative Services">Collaborative Services</a></p> </div> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_231 tinted" id="paragraph--231"> <div class="inner"> <h2 class="section__title">Canada&#039;s Michael Smith</h2> <h2 class="section__title">Genome Sciences Centre</h2> <div class="field field--summary"> <p>Harnessing cutting-edge genome sequencing and analytical techniques.</p> <p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="82165b81-8bc1-4a90-8341-651784775786" href="https://www.bcgsc.ca/about-us/technology-platforms" title="Technology Platforms">Technology Platform</a></p> </div> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_583 tinted" id="paragraph--583"> <div class="inner"> <h2 class="section__title">Canada&#039;s Michael Smith</h2> <h2 class="section__title">Genome Sciences Centre</h2> <div class="field field--summary"> <p>Enabling new ways to process, analyze and visualize genomic data.</p> <p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="0b3fb3af-15fd-4003-9ea8-a9e8d56d67fb" href="https://www.bcgsc.ca/resources/software" title="Software">Software Resources</a></p> </div> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_238 tinted" id="paragraph--238"> <div class="inner"> <h2 class="section__title">Canada&#039;s Michael Smith</h2> <h2 class="section__title">Genome Sciences Centre</h2> <div class="field field--summary"> <p>Realizing the social and economic benefits of genome science. </p> <p><a href="https://www.bcgsc.ca/research">Research Projects</a></p> </div> </div> </section> </div> </div></div></div> </div> </div> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article role="article" about="/canadas-michael-smith-genome-sciences-centre" class="node node--front full"> <div class="field field--body"><h2>Developing and deploying genomics technologies in support of cancer and life sciences research.</h2> <p>Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying cutting-edge genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science. </p></div> </article> <section class="layout layout__callout layout__parent__node has-background paragraph paragraph--type--callout paragraph--view-mode--default" id="technology-platform"> <div class="section__title"><h2 class="section__title">Technology Platform</h2></div> <div class="inner"> <div class="background"> </div> <div class="field field--summary"> <p>The GSC is available to support your research. We guide experimental design, facilitate the processing of complex biological samples and provide numerous sequencing and bioinformatic services with the aim of making genomics accessible to the international scientific community. Explore our <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="82165b81-8bc1-4a90-8341-651784775786" href="https://www.bcgsc.ca/about-us/technology-platforms" title="Technology Platforms">technology platforms</a> and <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="135724e3-2362-4712-8cc4-63f4ef7b0062" href="https://www.bcgsc.ca/services" title="Collaborative Services">services</a>, and if you have questions or would like to collaborate please fill out our <a href="https://www.bcgsc.ca/form/service-request?service=526">contact form </a>or speak directly with one of our <a href="https://www.bcgsc.ca/people/directors-platform-leaders">platform leaders</a>.</p> <p>The GSC is <a href="https://www.bcgsc.ca/sites/default/files/2024-10/C0786647-IM1_certificate-2024-12-2.pdf">ISO27001</a> certified for information security management.</p> </div> </div> </section> <section class="layout layout__callout layout__parent__node has-background paragraph paragraph--type--callout paragraph--view-mode--default" id="scientific-research"> <div class="section__title"><h2 class="section__title">Scientific Research</h2></div> <div class="inner"> <div class="background"> </div> <div class="field field--summary"> <p>The 16 <a href="https://www.bcgsc.ca/people/faculty">faculty members</a> at the GSC have a diverse range of expertise in genomics, bioinformatics, proteomics, epigenomics, immunogenetics, cancer biology, computer science and <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="0b3fb3af-15fd-4003-9ea8-a9e8d56d67fb" href="https://www.bcgsc.ca/resources/software" title="Software">software development</a>. Together, we apply our knowledge to advance the global understanding of cancer and other diseases with an ultimate aim toward improving human health through disease prevention, the development of novel diagnostic strategies and by uncovering new therapeutic approaches, all the while helping the world to realize the social and economic benefits of genome <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="2b4fd57d-b796-42ff-84f8-9d8f5204ae5a" href="https://www.bcgsc.ca/research" title="Research">research</a>.</p> </div> </div> </section> <section class="layout layout__callout layout__parent__node has-background paragraph paragraph--type--callout paragraph--view-mode--default" id="clinical-programs"> <div class="section__title"><h2 class="section__title">Clinical Programs</h2></div> <div class="inner"> <div class="background"> </div> <div class="field field--summary"> <p>The GSC is unique in that it fosters close collaborations between scientists and clinicians, allowing for an unencumbered focus on direct translational research. Through the <a href="https://www.personalizedoncogenomics.org/">Personalized OncoGenomics (POG) program</a>, the GSC deploys whole genome and transcriptome sequencing to inform therapeutic and management strategies for late-stage cancer patients in real time. The GSC is also certified by the <a href="https://www.bcgsc.ca/sites/default/files/certificates/CAP%20certificate%202021.jpg">College of American Pathologists (CAP)</a> and the <a href="https://www.bcgsc.ca/sites/default/files/certificates/DAP%20Certificate%202021-2026.pdf">Diagnostic Accreditation Program (DAP) </a>to perform clinical genomic panel testing.</p> </div> </div> </section> <section class="layout layout__callout layout__parent__node paragraph paragraph--type--callout paragraph--view-mode--default" id="questions"> <div class="section__title"><h2 class="section__title">Questions?</h2></div> <div class="inner"> <div class="field field--summary"> <p>Please feel free to speak with one of our Platform Leaders directly:</p> </div> </div> </section> <section class="layout layout__profiles layout__parent__node per-row-4 paragraph paragraph--type--profiles paragraph--view-mode--default" id="paragraph--149"> <h2 class="section__title">Directors &amp; Platform Leaders</h2> <div class="profiles"><article role="article" about="/people/steven-jones" class="node node--profile teaser"> <a class="picture" href="/people/steven-jones" ><figure> <img src="/sites/default/files/styles/profile/public/2021-02/Steve%20Jones-grey.png?itok=FaK7pd34" width="580" height="460" alt="" typeof="foaf:Image" /> </figure></a> <section> <h3 class="node__title"> <a href="/people/steven-jones" rel="bookmark">Dr. Steven Jones, PhD, FRS(C), FCAHS, FRCP(Edin)</a> </h3> <div role="article" about="/people/steven-jones" class="node node--profile teaser field field--item field--field_profile_title"> Interim Department Head </div> <div role="article" about="/people/steven-jones" class="node node--profile teaser field field--item field--field_profile_title"> Co-Director </div> <div role="article" about="/people/steven-jones" class="node node--profile teaser field field--item field--field_profile_title"> Head, Bioinformatics </div> <div role="article" about="/people/steven-jones" class="node node--profile teaser field field--item field--field_profile_title"> Distinguished Scientist </div> <div class="contact"> <div class="field field--field_email_address"> <a href="mailto:sjones@bcgsc.ca">sjones@bcgsc.ca</a></div> <div class="field field--field_phone_number"><a href="tel:604-877-6083"> 604-877-6083</a></div> <a href="/people/steven-jones" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> <article role="article" about="/people/robert-holt" class="node node--profile teaser"> <a class="picture" href="/people/robert-holt" ><figure> <img src="/sites/default/files/styles/profile/public/2021-02/Photo_RHolt.png?itok=NuZq5n5W" width="580" height="460" alt="" typeof="foaf:Image" /> </figure></a> <section> <h3 class="node__title"> <a href="/people/robert-holt" rel="bookmark">Dr. Robert Holt, PhD</a> </h3> <div role="article" about="/people/robert-holt" class="node node--profile teaser field field--item field--field_profile_title"> Co-director, BC Cancer Immunotherapy Program </div> <div role="article" about="/people/robert-holt" class="node node--profile teaser field field--item field--field_profile_title"> Distinguished Scientist </div> <div class="contact"> <div class="field field--field_email_address"> <a href="mailto:rholt@bcgsc.ca">rholt@bcgsc.ca</a></div> <div class="field field--field_phone_number"><a href="tel:604-675-8165">604-675-8165</a></div> <a href="/people/robert-holt" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> <article role="article" about="/people/andy-mungall" class="node node--profile teaser"> <a class="picture" href="/people/andy-mungall" ><figure> <img src="/sites/default/files/styles/profile/public/2021-02/andy_mungall.png?itok=-dEFn6Hc" width="580" height="460" alt="" typeof="foaf:Image" /> </figure></a> <section> <h3 class="node__title"> <a href="/people/andy-mungall" rel="bookmark">Dr. Andy Mungall, PhD</a> </h3> <div role="article" about="/people/andy-mungall" class="node node--profile teaser field field--item field--field_profile_title"> Interim Co-Director </div> <div role="article" about="/people/andy-mungall" class="node node--profile teaser field field--item field--field_profile_title"> Group Leader, Biospecimen &amp; 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On October 22, 2024, we hosted our inaugural Collaborator Forum, bringing together a vibrant mix of researchers, industry experts, and both old and new colleagues to celebrate decades of collaboration and to foster new scientific partnerships.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/news/reflections-our-inaugural-gsc-collaborator-forum-2024" rel="tag" title="Reflections from our Inaugural GSC Collaborator Forum 2024" hreflang="en">Learn more<span class="visually-hidden"> about Reflections from our Inaugural GSC Collaborator Forum 2024</span></a></li></ul> </div> </article> </div><div class="teasers"><article role="article" about="/news/gsc-partners-genome-bcs-geneskool-bring-genomics-classrooms" typeof="Article" class="node--article teaser"> <a href="/news/gsc-partners-genome-bcs-geneskool-bring-genomics-classrooms" class="image"> <img src="/sites/default/files/styles/full_article/public/2020-01/GSC%20logo.png?itok=ecQ7Q1ya" width="1000" height="600" alt="" typeof="Image" /> </a> <div class="node__inner"> <footer class="node"> <article typeof="Person" about="/user/167"> </article> <div> <span property="schema:dateCreated" content="00">Sep 20, 2024</span> <span property="schema:dateCreated" content="00" class="hidden"></span> </div> </footer> <h2 class="node__title"><a href="/news/gsc-partners-genome-bcs-geneskool-bring-genomics-classrooms" rel="bookmark"><span property="schema:name">GSC Partners With Genome BC&#039;s Geneskool to Bring Genomics to Classrooms</span> </a></h2> <span property="schema:name" content="GSC Partners With Genome BC&#039;s Geneskool to Bring Genomics to Classrooms" class="hidden"></span> <div property="schema:text" class="field field--body"><p><img alt="Geneskool logo" data-entity-type="" data-entity-uuid="" src="https://www.bcgsc.ca/sites/default/files/2024-08/Geneskool-Emblem-2022-ROUND_RGB-1024px.jpg" class="align-center" /></p> <p>The GSC is excited to partner with Genome BC (GBC)’s <a href="https://www.genomebc.ca/education/what-is-geneskool">Geneskool</a> to bring real-world genomics into the classroom as we re-open our doors to students and their teachers for educational tours. </p></div> <ul class="links inline"><li class="node-readmore"><a href="/news/gsc-partners-genome-bcs-geneskool-bring-genomics-classrooms" rel="tag" title="GSC Partners With Genome BC&#039;s Geneskool to Bring Genomics to Classrooms" hreflang="en">Learn more<span class="visually-hidden"> about GSC Partners With Genome BC&#039;s Geneskool to Bring Genomics to Classrooms</span></a></li></ul> </div> </article> <article role="article" about="/news/registration-now-open-inaugural-gsc-collaborator-forum" typeof="Article" class="node--article teaser"> <a href="/news/registration-now-open-inaugural-gsc-collaborator-forum" class="image"> <img src="/sites/default/files/styles/full_article/public/2020-01/GSC%20logo.png?itok=ecQ7Q1ya" width="1000" height="600" alt="" typeof="Image" /> </a> <div class="node__inner"> <footer class="node"> <article typeof="Person" about="/user/167"> </article> <div> <span property="schema:dateCreated" content="00">Sep 20, 2024</span> <span property="schema:dateCreated" content="00" class="hidden"></span> </div> </footer> <h2 class="node__title"><a href="/news/registration-now-open-inaugural-gsc-collaborator-forum" rel="bookmark"><span property="schema:name">Registration Now Open for Inaugural GSC Collaborator Forum</span> </a></h2> <span property="schema:name" content="Registration Now Open for Inaugural GSC Collaborator Forum" class="hidden"></span> <div property="schema:text" class="field field--body"><p>Registrations are now open for the Inaugural GSC Collaborator Forum on Tuesday, October 22nd!</p> <p>An exciting line-up of invited speakers will share insights into topics ranging from plant genomes to the latest advances in cancer research. Join us for a day of sharing technical expertise and networking with Vancouver’s vibrant genomic research community!</p> <p>Register here: <a href="https://www.eventbrite.com/e/gsc-collaborator-forum-tickets-1005351151357?aff=oddtdtcreator">https://www.eventbrite.com/e/gsc-collaborator-forum-tickets-1005351151357?aff=oddtdtcreator</a></p></div> <ul class="links inline"><li class="node-readmore"><a href="/news/registration-now-open-inaugural-gsc-collaborator-forum" rel="tag" title="Registration Now Open for Inaugural GSC Collaborator Forum" hreflang="en">Learn more<span class="visually-hidden"> about Registration Now Open for Inaugural GSC Collaborator Forum</span></a></li></ul> </div> </article> <article role="article" about="/news/two-bc-cancer-research-teams-awarded-2024-competition-prestigious-terry-fox-new-frontiers" typeof="Article" class="node--article teaser"> <a href="/news/two-bc-cancer-research-teams-awarded-2024-competition-prestigious-terry-fox-new-frontiers" class="image"><figure class="remote-image"><img src="//www.bccrc.ca/sites/bccrc.ca/files/styles/large/public/2024-09/Nelson%20Karsan.png?itok=Puua2Ch_" alt=""></figure></a> <div class="node__inner"> <footer class="node"> <article typeof="Person" about="/user/1"> </article> <div> <span property="schema:dateCreated" content="00">Sep 10, 2024</span> <span property="schema:dateCreated" content="00" class="hidden"></span> </div> </footer> <h2 class="node__title"><a href="/news/two-bc-cancer-research-teams-awarded-2024-competition-prestigious-terry-fox-new-frontiers" rel="bookmark"><span property="schema:name">Two BC Cancer research teams awarded in 2024 competition for prestigious Terry Fox New Frontiers Program Project Grants </span> </a></h2> <span property="schema:name" content="Two BC Cancer research teams awarded in 2024 competition for prestigious Terry Fox New Frontiers Program Project Grants " class="hidden"></span> <div property="schema:text" class="field field--body"><p>Two BC Cancer research teams are 2024 recipients of the Terry Fox New Frontiers Program Project Grants (PPG), receiving new and renewal funding to advance cancer research and improve treatments. </p><p><strong>Project: Integrated Immunotherapy for Ovarian Cancer</strong></p><p>One of this year’s newly funded teams is based in Victoria and led by Dr. Brad Nelson. </p><p>Dr. Nelson, a BC Cancer Research Institute distinguished scientist and director of the Deeley Research Centre, will lead a team studying the immune system to improve treatments for high-grade serous ovarian cancer. </p></div> <ul class="links inline"><li class="node-readmore"><a href="/news/two-bc-cancer-research-teams-awarded-2024-competition-prestigious-terry-fox-new-frontiers" rel="tag" title="Two BC Cancer research teams awarded in 2024 competition for prestigious Terry Fox New Frontiers Program Project Grants " hreflang="en">Learn more<span class="visually-hidden"> about Two BC Cancer research teams awarded in 2024 competition for prestigious Terry Fox New Frontiers Program Project Grants </span></a></li></ul> </div> </article> </div></div> </section> </section> <section id="block-twitterfeed" class="block block--block-content8c04dfe8-d900-4520-8032-bd9d352357f1 block-twitterfeed"> <div class="field field--body"><style> <!--/*--><![CDATA[/* ><!--*/ #twitter-wrapper { text-align: center; /*--><!]]>*/ </style><div id="twitter-wrapper"> <a class="twitter-timeline" data-height="500" data-width="750" href="https://twitter.com/BCCancer_GSC?ref_src=twsrc%5Etfw">Tweets by BCCancer_GSC</a> <script async="" src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div></div> </section> <section class="views-element-container block block--views-blockpublications-block-2 block--publications block-views-block-publications-block-2" id="block-views-block-publications-block-2"> <h2 class="section__title">Publications</h2> <div><div class="js-view-dom-id-aa8ce7c66414a1a1f9842c8809af7d99f9067489eb55f16ea488114f68533c61 view view--publications"> <div class="views-view-grid view--publications cols-3"> <article role="article" about="/publications/mining-amphibian-and-insect-transcriptomes-antimicrobial-peptide-sequences-rampage"> <p class="node__title"><a href="https://www.ncbi.nlm.nih.gov/pubmed/35884206" target="_blank" rel="bookmark"><span>Mining Amphibian and Insect Transcriptomes for Antimicrobial Peptide Sequences with rAMPage</span> </a></p> <div class="field field--field_journal">Antibiotics</div> <div class="field field--field_authors">Diana Lin, Darcy Sutherland, Sambina Islam Aninta, Nathan Louie, Ka Ming Nip, Chenkai Li, Anat Yanai, Lauren Coombe, René L. Warren, Caren C. Helbing, Linda M. N. Hoang, Inanc Birol</div> </article> <article role="article" about="/publications/deep-whole-genome-ctdna-chronology-treatment-resistant-prostate-cancer"> <p class="node__title"><a href="https://www.ncbi.nlm.nih.gov/pubmed/35859180" target="_blank" rel="bookmark"><span>Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer</span> </a></p> <div class="field field--field_journal">Nature</div> <div class="field field--field_authors">Cameron Herberts, Matti Annala, Joonatan Sipola, Sarah W S Ng, Xinyi E Chen, Anssi Nurminen, Olga V Korhonen, Aslı D Munzur, Kevin Beja, Elena Schönlau, Cecily Q Bernales, Elie Ritch, Jack V W Bacon, Nathan A Lack, Matti Nykter, Rahul Aggarwal, Eric J Small, Martin E Gleave, David A Quigley, Felix Y Feng, Kim N Chi, Alexander W Wyatt</div> </article> <article role="article" about="/publications/super-enhancer-hypermutation-alters-oncogene-expression-b-cell-lymphoma"> <p class="node__title"><a href="https://www.ncbi.nlm.nih.gov/pubmed/35794478" target="_blank" rel="bookmark"><span>Super-enhancer hypermutation alters oncogene expression in B cell lymphoma</span> </a></p> <div class="field field--field_journal">Nature</div> <div class="field field--field_authors">Elodie Bal, Rahul Kumar, Mohammad Hadigol, Antony B Holmes, Laura K Hilton, Jui Wan Loh, Kostiantyn Dreval, Jasper C H Wong, Sofija Vlasevska, Clarissa Corinaldesi, Rajesh Kumar Soni, Katia Basso, Ryan D Morin, Hossein Khiabanian, Laura Pasqualucci, Riccardo Dalla-Favera. </div> </article> </div> <nav role="navigation" aria-labelledby="pagination-heading"> <h4 class="visually-hidden">Pagination</h4> <ul class="js-pager__items pager__items mini"> <li> <a href="/canadas-michael-smith-genome-sciences-centre?page=1" title="Go to next page" rel="next"> <span class="visually-hidden">Next page</span> <span aria-hidden="true">››</span> </a> </li> </ul> </nav> </div> </div> </section> </div> </section> </div> <a class="top" href="#main-content">Back to top</a> </main> <section class="region region__cta"> <div class="region__cta--inner region--inner"> <section id="block-sitecalltoaction" class="block block--block-contenta8a59224-4648-42d5-b71c-294b3c630d8a block-sitecalltoaction"> <div class="field field--body"><p>BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. 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