Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic D

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Many of these challenges pe..110404"/> <meta name="citation_publisher" content="国際オンライン医療評議会" /> <meta name="citation_journal_title" content="腫瘍学およびがんの症例報告"> <meta name="citation_title" content="Synchronous Cancers: Acute Myeloid Leukemia and Pancreatic Ductal Adenocarcinoma with Germline Heterozygous DDX41 and MUTYH Mutations in a Patient from Appalachia, United States"> <meta name="citation_author" content="Bhavana Bhatnagar" /> <meta name="citation_author" content="Christen Jordan" /> <meta name="citation_author" content="Cara R" /> <meta name="citation_author" content="all4" /> <meta name="citation_author" content="Andrew Gordon" /> <meta name="citation_author" content="Christinea Marino" /> <meta name="citation_author" content="Angela Burrie" /> <meta name="citation_author" content="Ashkan Emadi" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="10"> <meta name="citation_issue" content="3"> <meta name="citation_abstract" content="A diagnosis of synchronous cancers within the same individual poses a multitude of diagnostic and treatment-related challenges. Many of these challenges pertain to the vast heterogeneity in cancers and presentations, patient ineligibility for clinical trials, lack of standardized guidelines to direct management and an incomplete understanding of the molecular mechanisms that contribute to the development of these cancers. We present a case of concurrent diagnoses of Pancreatic Ductal Adenocarcinoma (PDAC) and Acute Myeloid Leukemia (AML) with a comprehensive mutational analysis of the pancreatic tumor, AML blasts, and germline DNA collected from cultured skin fibroblast samples. In addition to some commonly detected mutations (e.g. KRAS Gly12Asp in PDAC and TP53 Met237lle in AML), the genetic testing revealed the presence of DDX41 and MUTYH gene mutations in both germline DNA and tumor tissue specimens. This case underscores the importance of addressing the interplay of genetic, lifestyle and environmental factors in the development of synchronous cancers in an individual, and only by doing so, evidence-based guidelines for early detection and management may be developed."> <meta name="citation_abstract_html_url" content="https://japanese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"> </head> <body> <header>  <div class="bg-1"> <div class="container-fluid py-1"> <div class="row justify-content-between align-items-center"> <div class="col-sm-auto"> <a href="https://japanese.iomcworld.org/" title="IOMC"><img src="/assets/img/IOMC-logo-white.svg" alt="occrs" height="50" alt="IOMC"></a> </div> <div class="col-sm-auto"> <nav class="nav"> <a class="nav-link white"><i class="fa fa-whatsapp"></i> +32(800) 709-48 </a> <a href="mailto:oncology@oncologyinsights.org" class="nav-link white"><i class="fas fa-envelope-square"></i> oncology@oncologyinsights.org</a>  <div class="nav-item dropdown multi_lang j_multi_lang"> <a class="nav-link dropdown-toggle" href="#" id="multi_lang" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Language </a> <div class="dropdown-menu" aria-labelledby=""> <a class="dropdown-item" href="https://www.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="English"> <img src="https://www.longdom.org/admin/flags/usa.png">English </a> <a class="dropdown-item" href="https://spanish.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Spanish"> <img src="https://www.longdom.org/admin/flags/spain.png">Spanish </a> <a class="dropdown-item" href="https://chinese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Chinese"> <img src="https://www.longdom.org/admin/flags/china.png">Chinese </a> <a class="dropdown-item" href="https://russian.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Russian"> <img src="https://www.longdom.org/admin/flags/russia.png">Russian </a> <a class="dropdown-item" href="https://german.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="German"> <img src="https://www.longdom.org/admin/flags/germany.png">German </a> <a class="dropdown-item" href="https://french.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="French"> <img src="https://www.longdom.org/admin/flags/france.png">French </a> <a class="dropdown-item" href="https://portuguese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Portuguese"> <img src="https://www.longdom.org/admin/flags/portugal.png">Portuguese </a> <a class="dropdown-item" href="https://hindi.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Hindi"> <img src="https://www.longdom.org/admin/flags/india.png">Hindi </a> <a class="dropdown-item" href="https://telugu.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Telugu"> <img src="https://www.longdom.org/admin/flags/india.png">Telugu </a> <a class="dropdown-item" href="https://tamil.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html" title="Tamil"> <img src="https://www.longdom.org/admin/flags/india.png">Tamil </a> </div> </div>  </nav> </div> </div> </div> </div>  <div class="py-3"> <div class="container-fluid"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-auto"> <h1 class="rockwell fweight-600 mb-0">腫瘍学およびがんの症例報告</h1> <span class="float-right">ISSN - 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Many of these challenges pertain to the vast heterogeneity in cancers and presentations, patient ineligibility for clinical trials, lack of standardized guidelines to direct management and an incomplete understanding of the molecular mechanisms that contribute to the development of these cancers. We present a case of concurrent diagnoses of Pancreatic Ductal Adenocarcinoma (PDAC) and Acute Myeloid Leukemia (AML) with a comprehensive mutational analysis of the pancreatic tumor, AML blasts, and germline DNA collected from cultured skin fibroblast samples. In addition to some commonly detected mutations (e.g. KRAS Gly12Asp in PDAC and TP53 Met237lle in AML), the genetic testing revealed the presence of DDX41 and MUTYH gene mutations in both germline DNA and tumor tissue specimens. This case underscores the importance of addressing the interplay of genetic, lifestyle and environmental factors in the development of synchronous cancers in an individual, and only by doing so, evidence-based guidelines for early detection and management may be developed.</p> </p> <div class="alert alert-info text-left"><b>免責事項:</b> この要約は人工知能ツールを使用して翻訳されたものであり、まだレビューまたは検証されていません。</div> <div class="nav social-icons"> <a class="nav-link w-auto">この記事をシェアする</a> <a title="" target="_blank" href="https://www.facebook.com/sharer.php?u=https://japanese.iomcworld.org/abstract/synchronous-cancers-acute-myeloid-leukemia-and-pancreatic-ductal-adenocarcinoma-with-germline-heterozygous-ddx41-and-mut-110404.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="" target="_blank" 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