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Twenty years of therapy for HIV-1 infection - Peeref

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NATURE MEDICINE </a> </h5> <span> Volume 9, Issue 7, Pages 867-873 </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">Publisher</h4> <div class="f16"> <h5 class="title f16 text-primary"> NATURE RESEARCH </h5> <div class="my-2"> DOI: 10.1038/nm0703-867 </div> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">Keywords</h4> <div class="f16"> - </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">Categories</h4> <div class="f16"> <span class="d-block"> <a href="https://www.peeref.com/works/list?category=Biochemistry+%26+Molecular+Biology" target="_blank" class="text-dark btn btn-link p-0 text-left"> Biochemistry &amp; Molecular Biology </a> </span> <span class="d-block"> <a href="https://www.peeref.com/works/list?category=Cell+Biology" target="_blank" class="text-dark btn btn-link p-0 text-left"> Cell Biology </a> </span> <span class="d-block"> <a href="https://www.peeref.com/works/list?category=Medicine%2C+Research+%26+Experimental" target="_blank" class="text-dark btn 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<div class="col-md-8 px-0 pl-md-3"> <div id="article-summary-panel" class="mb-4"> <ul class="nav nav-tabs" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#raw_abstract" data-toggle="tab" class="abstract-tab mx-0 f16 text-dark"> <strong>Abstract</strong> </a> </li> </ul> <div class="tab-content border border-top-0"> <div id="raw_abstract" class="tab-pane active"> <div class="abstract-panel panel-box mb-0 rounded shadow-none"> <div class="f16">Antiretroviral therapy, where available, has transformed HIV-1 disease into a treatable and somewhat chronic infection. This article summarizes the accomplishments thus far and what lies ahead in our struggle to improve the treatment of, and possibly eliminate, HIV-1 infection.</div> </div> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">Authors</h4> <div class="mb-3"> <article-authors tid="71804160" list="[{&quot;name&quot;:&quot;RJ Pomerantz&quot;,&quot;sequence&quot;:1},{&quot;name&quot;:&quot;DL Horn&quot;,&quot;sequence&quot;:2}]" verified="[]" page="work" ></article-authors> </div> <div class="alert alert-warning mb-0"> <h5 class="mt-0 bg-warning text-dark px-3 rounded d-inline-block"> I am an author on this paper </h5> <div class="font-weight-bold f13"> Click your name to claim this paper and add it to your profile. </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">Reviews</h4> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="flex-grow-1"> <h4 class="f16"> Primary Rating <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="The primary rating indicates the level of overall quality for the paper."> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap align-items-center alert mb-0"> <div class="d-flex align-items-center justify-content-center"> <Rate disabled allow-half value="4.8" style="font-size: 28px;"></Rate> <strong class="f20 m-3" style="color: #f5a623;">4.8</strong> </div> <div class="text-muted mx-4"> Not enough ratings </div> </div> <h4 class="f16"> Secondary Ratings <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="Secondary ratings independently reflect strengths or weaknesses of the paper."> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap alert"> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">Novelty</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">Significance</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">Scientific rigor</h5> <strong class="mx-4">-</strong> </div> </div> </div> <div class="flex-shrink-0"> <div class="border bg-light py-2 px-4"> <h5 class="mb-1">Rate this paper</h5> <Rate class="f24" @on-change="function(value){ location.href='https://www.peeref.com/works/71804160/comments?rating='+value }"></Rate> </div> </div> </div> </div> <div id="collection" class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">Recommended</h4> <div class="my-3"> <ul class="nav nav-pills border-bottom pb-3" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#articles_from_related" data-toggle="tab" class="mx-0 f15"> <strong>Related</strong> </a> </li> <li class=""> <a href="#articles_from_authors" data-toggle="tab" class="mx-0 f15"> <strong>From Same Authors</strong> </a> </li> <li class=""> <a href="#articles_from_journal" data-toggle="tab" class="mx-0 f15"> <strong>From Same Journal</strong> </a> </li> </ul> <div class="tab-content"> <div id="articles_from_related" class="tab-pane active"> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Microbiology </span> </div> <h4> <a href="https://www.peeref.com/works/82001582" class="text-dark hover-underline">Pregnancy Management in HIV Viral Controllers: Twenty Years of Experience</a> </h4> <p class="text-ellipsis-2">Charlotte-Eve S. Short, Laura Byrne, Aishah Hagan-Bezgin, Rachael A. Quinlan, Jane Anderson, Gary Brook, Okavas De Alwis, Annemiek de Ruiter, Pippa Farrugia, Sarah Fidler, Eleanor Hamlyn, Anna Hartley, Siobhan Murphy, Heather Noble, Soonita Oomeer, Sherie Roedling, Melanie Rosenvinge, Luciana Rubinstein, Rimi Shah, Selena Singh, Elizabeth Thorne, Martina Toby, Brenton Wait, Liat Sarner, Graham P. Taylor</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10659.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This is a study on the management of pregnancies in UK women with spontaneous HIV viral control. The results showed that the management approach changed after 2012, with more use of triple antiretroviral therapy, but the cesarean section rate was not significantly affected. The study also found that a certain proportion of HIV was detected positive during pregnancy, but no transmission was reported. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PATHOGENS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82001582/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Virology </span> </div> <h4> <a href="https://www.peeref.com/works/26094941" class="text-dark hover-underline">Romania, a Harbour of HIV-1 Subtype F1: Where Are We after 33 Years of HIV-1 Infection?</a> </h4> <p class="text-ellipsis-2">Madalina Preda, Loredana Cornelia Sabina Manolescu</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/8207.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> The HIV infection in Romania has been unique, with the dominance of F1 subtype and a recent increase in subtype B, which is mostly diagnosed in drug users and men having sex with men. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">VIRUSES-BASEL</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/26094941/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Virology </span> </div> <h4> <a href="https://www.peeref.com/works/28510004" class="text-dark hover-underline">HIV-DNA decrease during treatment in primary HIV-1 infection with three different drug regimens: Italian Network of Acute HIV Infection (INACTION) clinical trial</a> </h4> <p class="text-ellipsis-2">Elena Bruzzesi, Arianna Gabrieli, Davide Bernasconi, Giulia Marchetti, Andrea Calcagno, Diego Ripamonti, Andrea Antinori, Nicola Squillace, Antonella Cingolani, Antonio Muscatello, Alessandra Bandera, Andrea Gori, Stefano Rusconi, Silvia Nozza, INACTION Study Grp</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/4811.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> The introduction of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) can restrict the establishment of HIV reservoirs. This study aimed to assess the effect of three different ART regimens on HIV-DNA load in individuals living with HIV (PLWH) who started ART in PHI. The results showed that regardless of the treatment regimen, the HIV-DNA load in PLWH decreased during the treatment period. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF MEDICAL VIROLOGY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/28510004/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/28618140" class="text-dark hover-underline">HIV-PULSE: a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization</a> </h4> <p class="text-ellipsis-2">Laurens Lambrechts, Noah Bonine, Rita Verstraeten, Marion Pardons, Ytse Noppe, Sofie Rutsaert, Filip Van Nieuwerburgh, Wim Van Criekinge, Basiel Cole, Linos Vandekerckhove</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6280.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> HIV-PULSE is a high-throughput, long-read sequencing assay for characterizing the HIV-1 proviral landscape. It uses unique molecular identifiers (UMIs) to tag individual HIV-1 genomes, allowing for the omission of the limiting dilution step and enabling long-range PCR amplification of many NFL genomes in a single PCR reaction, while simultaneously overcoming poor single-read accuracy. The assay is cost-efficient and scalable, and has similar sensitivity and good concordance compared to the widely applied Full-Length Individual Proviral Sequencing assay. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NUCLEIC ACIDS RESEARCH</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/28618140/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Editorial Material </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/works/24780297" class="text-dark hover-underline">Twenty-five years of nanoscale thermodynamics</a> </h4> <p class="text-ellipsis-2">Chase P. Broedersz, Pierre Ronceray</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6054.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper discusses how the Jarzynski equality updates the second law of thermodynamics by extending the physics of transformations from steam engines to molecular motors. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/24780297/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Medicine, Research &amp; Experimental </span> </div> <h4> <a href="https://www.peeref.com/works/35097577" class="text-dark hover-underline">The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memo CD4+ T cells</a> </h4> <p class="text-ellipsis-2">Gabriel Duette, Bonnie Hiener, Hannah Morgan, Fernando G. Mazur, Vennila Mathivanan, Bethany A. Horsburgh, Katie Fisher, Orion Tong, Eunok Lee, Haelee Ahn, Ansari Shaik, Remi Fromentin, Rebecca Hoh, Charline Bacchus-Souffan, Najla Nasr, Anthony L. Cunningham, Peter W. Hunt, Nicolas Chomont, Stuart G. Turville, Steven G. Deeks, Anthony D. Kelleher, Timothy E. Schlub, Sarah Palmer</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/4315.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Through studying CD4(+) T cells of HIV-1 patients, the importance of effector memory T cells in the persistence of HIV-1 has been identified, and Nef has been suggested as a potential therapeutic target. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF CLINICAL INVESTIGATION</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/35097577/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/works/24820365" class="text-dark hover-underline">Effectiveness of three delivery models for promoting access to pre-exposure prophylaxis in HIV-1 serodiscordant couples in Nigeria</a> </h4> <p class="text-ellipsis-2">Morenike Oluwatoyin Folayan, Sani Aliyu, Ayodeji Oginni, Oliver Ezechi, Grace Kolawole, Nkiru Ezeama, Nancin Dadem, James Anenih, Matthias Alagi, Etim Ekanem, Evaristus Afiadigwe, Rose Aguolu, Tinuade Oyebode, Alero Babalola-Jacobs, Atiene Sagay, Chidi Nweneka, Hadiza Kamofu, John Idoko</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6775.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study evaluated the effectiveness of three models for delivering PrEP services to HIV-1 serodiscordant couples in Nigeria. The study found that there was no significant difference in couple retention rates among the three models, indicating that all models can effectively deliver PrEP services. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PLOS ONE</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/24820365/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Mathematical &amp; Computational Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83337793" class="text-dark hover-underline">Modelling HIV-1 control and remission</a> </h4> <p class="text-ellipsis-2">Bharadwaj Vemparala, Shreya Chowdhury, Jeremie Guedj, Narendra M. Dixit</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10941.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Mathematical modelling has contributed significantly to the development of interventions for long-term remission of HIV-1 infection. It has helped elucidate mechanisms, deduce pathways of control loss, quantify effects, and develop optimization frameworks. However, important questions remain, posing challenges to the translation of these promising interventions. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NPJ SYSTEMS BIOLOGY AND APPLICATIONS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83337793/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Immunology </span> </div> <h4> <a href="https://www.peeref.com/works/25237450" class="text-dark hover-underline">Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy</a> </h4> <p class="text-ellipsis-2">Aljawharah Alrubayyi, Sarah Rowland-Jones, Dimitra Peppa</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/349.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This review focuses on the known and unknown roles of NK cell subsets in controlling acute HIV-1 infection, as well as recent advances in selectively enhancing NK cell functions through prophylactic and therapeutic interventions. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">AIDS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/25237450/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biotechnology &amp; Applied Microbiology </span> </div> <h4> <a href="https://www.peeref.com/works/83023816" class="text-dark hover-underline">Tat-dependent conditionally replicating adenoviruses expressing diphtheria toxin A for specifically killing HIV-1-infected cells</a> </h4> <p class="text-ellipsis-2">Fengfeng Ni, Kai Hu, Miaomiao Li, Mengshi Yang, Yingying Xiao, Ming Fu, Zhiyuan Zhu, Yalan Liu, Qinxue Hu</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/5989.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study constructed a Tat-dependent conditionally replicating adenovirus Tat-CRAds-DTA, which selectively replicates and expresses diphtheria toxin A chain in HIV-1-infected cells, induces cell death and inhibits virus replication, shows no obvious cytotoxicity to HIV-1-negative cells, and demonstrates significant therapeutic efficacy in a humanized mouse model, providing a new gene therapy strategy for the treatment of HIV-1 infection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">MOLECULAR THERAPY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83023816/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biology </span> </div> <h4> <a href="https://www.peeref.com/works/81721925" class="text-dark hover-underline">Twenty years of big plant genera</a> </h4> <p class="text-ellipsis-2">Peter W. Moonlight, Ludwig Baldaszti, Domingos Cardoso, Alan Elliott, Tiina Saerkinen, Sandra Knapp</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6901.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This article uses data from the World Flora Online to update the list of large (more than 500 species) and megadiverse (more than 1000 species) flowering plant genera and highlights changes since 2004. The number of large genera has increased from 57 to 86, and the growth is mainly due to the description of new species. Although the number of large genera has increased rapidly, they still represent an important but understudied proportion of plant diversity, and should remain a priority for understanding global diversity patterns and plant evolution in general. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/81721925/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/works/26100075" class="text-dark hover-underline">S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo</a> </h4> <p class="text-ellipsis-2">Fernando Real, Aiwei Zhu, Boxin Huang, Ania Belmellat, Alexis Sennepin, Thomas Vogl, Celine Ransy, Marc Revol, Riccardo Arrigucci, Anne Lombes, Johannes Roth, Maria Laura Gennaro, Frederic Bouillaud, Sarra Cristofari, Morgane Bomsel</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/8411.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study found that tissue-resident macrophages contain active HIV-1 virus and can produce and release the virus upon stimulation with the endogenous factor S100A8. These findings have important implications for future HIV eradication strategies. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE COMMUNICATIONS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/26100075/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/works/24820766" class="text-dark hover-underline">Association between low levels of HIV-1 DNA and HLA class I molecules in chronic HIV-1 infection</a> </h4> <p class="text-ellipsis-2">Camilla Muccini, Monica Guffanti, Vincenzo Spagnuolo, Massimo Cernuschi, Laura Galli, Alba Bigoloni, Andrea Galli, Andrea Poli, Sara Racca, Antonella Castagna</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6775.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study aimed to explore the association between HLA class I molecules and HIV-1 DNA in people with chronic HIV-1 infection, and the results suggest that HLA-B39 and -B55 may be associated with lower levels of HIV-1 DNA. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PLOS ONE</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/24820766/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Organic </span> </div> <h4> <a href="https://www.peeref.com/works/83012026" class="text-dark hover-underline">Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies</a> </h4> <p class="text-ellipsis-2">Arun K. Ghosh, Daniel Lee, Ashish Sharma, Megan E. Johnson, Ajay K. Ghosh, Yuan-Fang Wang, Johnson Agniswamy, Masayuki Amano, Shin-ichiro Hattori, Irene T. Weber, Hiroaki Mitsuya</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6414.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper describes the design and synthesis of substituted tetrahydrofuran derivatives as P2 ligands for HIV-1 protease inhibitors, and their activity testing and structural analysis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ORGANIC &amp; BIOMOLECULAR CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83012026/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Microbiology </span> </div> <h4> <a href="https://www.peeref.com/works/28895705" class="text-dark hover-underline">Socio-Demographic, Clinical, and Mortality Differences between HIV-Infected and HIV/HTLV-1 Co-Infected Patients in Peru</a> </h4> <p class="text-ellipsis-2">Maria Pia Amanzo-Vargas, Tessy Arellano-Veintemilla, Elsa Gonzalez-Lagos, Juan Echevarria, Fernando Mejia, Ana Grana, Eduardo Gotuzzo</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10659.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study compared the socio-demographic and clinical characteristics, and mortality rates between HIV-infected and HIV/HTLV-1 co-infected patients in Peru. The results showed that HIV/HTLV-1 co-infected patients had a significantly shorter survival time compared to HIV-infected patients. This suggests that the immune alterations caused by HTLV-1 in CD4 cell count may have contributed to late initiation of antiretroviral treatment and prophylaxis against opportunistic infections over the decades, and thus reducing their benefits in these patients. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PATHOGENS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/28895705/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> </div> <div id="articles_from_authors" class="tab-pane "> <div class="nodata my-4">No Data Available</div> </div> <div id="articles_from_journal" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/84530059" class="text-dark hover-underline">Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial</a> </h4> <p class="text-ellipsis-2">Zefei Jiang, Quchang Ouyang, Tao Sun, Qingyuan Zhang, Yuee Teng, Jiuwei Cui, Haibo Wang, Yongmei Yin, Xiaojia Wang, Xin Zhou, Yongsheng Wang, Gang Sun, Jingfen Wang, Lili Zhang, Jin Yang, Jun Qian, Min Yan, Xinlan Liu, Tienan Yi, Ying Cheng, Man Li, Aimin Zang, Shusen Wang, Chuan Wang, Xinhong Wu, Jing Cheng, Hui Li, Ying Lin, Cuizhi Geng, Kangsheng Gu, Chunwei Xie, Huihua Xiong, Xiaohong Wu, Junlan Yang, Qingshan Li, Yiding Chen, Fanfan Li, Anqin Zhang, Yongqiang Zhang, Yudong Wu, Jianyun Nie, Qiang Liu, Kun Wang, Xueli Mo, Lilin Chen, Yueyin Pan, Peifen Fu, Helong Zhang, Danmei Pang, Yuan Sheng, Yunwei Han, Hongxia Wang, Shundong Cang, Xianming Luo, Wenbo Yu, Rong Deng, Chaoqiang Yang, Patricia Keegan</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study evaluated the efficacy and safety of toripalimab combined with nab-paclitaxel versus placebo combined with nab-paclitaxel in women with metastatic or recurrent TNBC. The results showed that in the PD-L1 positive population, both PFS and overall survival in the experimental group were significantly improved, and the safety was acceptable. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/84530059/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/84529132" class="text-dark hover-underline">Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme</a> </h4> <p class="text-ellipsis-2">Alona Sosinsky, John Ambrose, William Cross, Clare Turnbull, Shirley Henderson, Louise Jones, Angela Hamblin, Prabhu Arumugam, Georgia Chan, Daniel Chubb, Boris Noyvert, Jonathan Mitchell, Susan Walker, Katy Bowman, Dorota Pasko, Marianna Buongermino Pereira, Nadezda Volkova, Antonio Rueda-Martin, Daniel Perez-Gil, Javier Lopez, John Pullinger, Afshan Siddiq, Tala Zainy, Tasnim Choudhury, Olena Yavorska, Tom Fowler, David Bentley, Clare Kingsley, Sandra Hing, Zandra Deans, Augusto Rendon, Sue Hill, Mark Caulfield, Nirupa Murugaesu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study evaluated the opportunities for precision cancer care within the UK NHS by analyzing WGS data from 13,880 solid tumors. The results showed that the incidence of somatic mutations varied across cancer types, and homologous recombination deficiency was associated with pathogenic germline variants. The study also found that linking genomic and clinical data for survival analysis can identify cancer genes that affect prognosis and help to understand the impact of cancer genomics on patient outcomes. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/84529132/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83554075" class="text-dark hover-underline">Data-driven risk stratification and precision management of pulmonary nodules detected on chest computed tomography</a> </h4> <p class="text-ellipsis-2">Chengdi Wang, Jun Shao, Yichu He, Jiaojiao Wu, Xingting Liu, Liuqing Yang, Ying Wei, Xiang Sean Zhou, Yiqiang Zhan, Feng Shi, Dinggang Shen, Weimin Li</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study proposes a triage-driven Chinese Lung Nodules Reporting and Data System (C-Lung-RADS) that utilizes medical checkup cohort data to precisely evaluate the malignancy risk of pulmonary nodules. The system operates in a stepwise fashion, integrating imaging information, demographic characteristics, and follow-up data to identify suspicious malignant nodules and refine the risk scale. The system demonstrates excellent performance in the internal testing dataset and shows higher sensitivity in an independent cohort. Based on precise risk stratification and tailored management, this system has the potential to enhance the efficiency of lung cancer diagnosis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83554075/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/84529730" class="text-dark hover-underline">Health effects associated with exposure to secondhand smoke: a Burden of Proof study</a> </h4> <p class="text-ellipsis-2">Luisa S. Flor, Jason A. Anderson, Noah Ahmad, Aleksandr Aravkin, Sinclair Carr, Xiaochen Dai, Gabriela F. Gil, Simon Hay, Matthew J. Malloy, Susan A. McLaughlin, Erin C. Mullany, Christopher J. L. Murray, Erin M. O&#039;Connell, Chukwuma Okereke, Reed J. D. Sorensen, Joanna Whisnant, Peng Zheng, Emmanuela Gakidou</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study comprehensively reviewed the literature on the adverse effects of secondhand smoke exposure on nine health outcomes. It found that secondhand smoke is associated with various health problems, including ischemic heart disease, stroke, type 2 diabetes, lung cancer, otitis media, asthma, lower respiratory infections, breast cancer, and chronic obstructive pulmonary disease. Although the evidence is weak, the results emphasize the harmful effects of secondhand smoke on health and the need to strengthen efforts to reduce smoking. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/84529730/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/82940322" class="text-dark hover-underline">Integrated image-based deep learning and language models for primary diabetes care</a> </h4> <p class="text-ellipsis-2">Jiajia Li, Zhouyu Guan, Jing Wang, Carol Y. Cheung, Yingfeng Zheng, Lee-Ling Lim, Cynthia Ciwei Lim, Paisan Ruamviboonsuk, Rajiv Raman, Leonor Corsino, Justin B. Echouffo-Tcheugui, Andrea O. Y. Luk, Li Jia Chen, Xiaodong Sun, Haslina Hamzah, Qiang Wu, Xiangning Wang, Ruhan Liu, Ya Xing Wang, Tingli Chen, Xiao Zhang, Xiaolong Yang, Jun Yin, Jing Wan, Wei Du, Ten Cheer Quek, Jocelyn Hui Lin Goh, Dawei Yang, Xiaoyan Hu, Truong X. Nguyen, Simon K. H. Szeto, Peranut Chotcomwongse, Rachid Malek, Nargiza Normatova, Nilufar Ibragimova, Ramyaa Srinivasan, Pingting Zhong, Wenyong Huang, Chenxin Deng, Lei Ruan, Cuntai Zhang, Chenxi Zhang, Yan Zhou, Chan Wu, Rongping Dai, Sky Wei Chee Koh, Adina Abdullah, Nicholas Ken Yoong Hee, Hong Chang Tan, Zhong Hong Liew, Carolyn Shan-Yeu Tien, Shih Ling Kao, Amanda Yuan Ling Lim, Shao Feng Mok, Lina Sun, Jing Gu, Liang Wu, Tingyao Li, Di Cheng, Zheyuan Wang, Yiming Qin, Ling Dai, Ziyao Meng, Jia Shu, Yuwei Lu, Nan Jiang, Tingting Hu, Shan Huang, Gengyou Huang, Shujie Yu, Dan Liu, Weizhi Ma, Minyi Guo, Xinping Guan, Xiaokang Yang, Covadonga Bascaran, Charles R. Cleland, Yuqian Bao, Elif I. Ekinci, Alicia Jenkins, Juliana C. N. Chan, Yong Mong Bee, Sobha Sivaprasad, Jonathan E. Shaw, Rafael Simo, Pearse A. Keane, Ching-Yu Cheng, Gavin Siew Wei Tan, Weiping Jia, Yih-Chung Tham, Huating Li, Bin Sheng, Tien Yin Wong</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> The study developed an integrated image-language system, DeepDR-LLM, to assist PCPs in diabetes management. The system performed well in identifying referable DR and also improved patients&#039; self-management behaviors and adherence to DR referrals, as well as the quality and empathy level of management recommendations. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82940322/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/82998523" class="text-dark hover-underline">Outpatient reception via collaboration between nurses and a large language model: a randomized controlled trial</a> </h4> <p class="text-ellipsis-2">Peixing Wan, Zigeng Huang, Wenjun Tang, Yulan Nie, Dajun Pei, Shaofen Deng, Jing Chen, Yizhi Zhou, Hongru Duan, Qingyu Chen, Erping Long</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study presents a method of leveraging large language models to assist communication in medical center reception sites. By creating a site-specific prompt engineering chatbot, the model effectively resolves patient queries and improves patient satisfaction, reduces repeated queries and negative emotions, and enhances response quality in practical applications. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/82998523/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83099090" class="text-dark hover-underline">Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes</a> </h4> <p class="text-ellipsis-2">Zhendong Mei, Fenglei Wang, Amrisha Bhosle, Danyue Dong, Raaj Mehta, Andrew Ghazi, Yancong Zhang, Yuxi Liu, Ehud Rinott, Siyuan Ma, Eric B. Rimm, Martha Daviglus, Walter C. Willett, Rob Knight, Frank B. Hu, Qibin Qi, Andrew T. Chan, Robert D. Burk, Meir J. Stampfer, Iris Shai, Robert C. Kaplan, Curtis Huttenhower, Dong D. Wang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study comprehensively analyzed the T2D microbiome, identified microbial species and community functional changes associated with T2D, and determined the relationships between intraspecies phylogenetic diversity and T2D risk for some strains. The study also revealed the associations of some strain-specific gene carriage and new biological processes with T2D. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83099090/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83282752" class="text-dark hover-underline">Brain aging patterns in a large and diverse cohort of 49,482 individuals</a> </h4> <p class="text-ellipsis-2">Zhijian Yang, Junhao Wen, Guray Erus, Sindhuja T. Govindarajan, Randa Melhem, Elizabeth Mamourian, Yuhan Cui, Dhivya Srinivasan, Ahmed Abdulkadir, Paraskevi Parmpi, Katharina Wittfeld, Hans J. Grabe, Robin Buelow, Stefan Frenzel, Duygu Tosun, Murat Bilgel, Yang An, Dahyun Yi, Daniel S. Marcus, Pamela Lamontagne, Tammie L. S. Benzinger, Susan R. Heckbert, Thomas R. Austin, Shari R. Waldstein, Michele K. Evans, Alan B. Zonderman, Lenore J. Launer, Aristeidis Sotiras, Mark A. Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Arthur W. Toga, Sid O&#039;Bryant, Mallar M. Chakravarty, Sylvia Villeneuve, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, Kristine Yaffe, Henry Voelzke, Luigi Ferrucci, R. Nick Bryan, Russell T. Shinohara, Yong Fan, Mohamad Habes, Paris Alexandros Lalousis, Nikolaos Koutsouleris, David A. Wolk, Susan M. Resnick, Haochang Shou, Ilya M. Nasrallah, Christos Davatzikos</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A generative model identifies five dominant patterns of brain atrophy in a cohort of 49,482 individuals from 11 studies, with specific associations with biomedical, lifestyle, and genetic factors. These findings provide insights into the mechanisms of brain aging and offer new avenues for the diagnosis and treatment of diseases. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83282752/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83265032" class="text-dark hover-underline">Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety</a> </h4> <p class="text-ellipsis-2">Leonardo Tozzi, Xue Zhang, Adam Pines, Alisa M. Olmsted, Emily S. Zhai, Esther T. Anene, Megan Chesnut, Bailey Holt-Gosselin, Sarah Chang, Patrick C. Stetz, Carolina A. Ramirez, Laura M. Hack, Mayuresh S. Korgaonkar, Max Wintermark, Ian H. Gotlib, Jun Ma, Leanne M. Williams</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study used data from a standardized functional magnetic resonance imaging protocol to derive brain circuit dysfunction scores based on theoretical taxonomy and subdivided patients into six biotypes. These biotypes were distinguished by symptoms, behavioral performance, and response to treatment. The study provides a new quantitative method for parsing the biological heterogeneity of depression and anxiety and advancing precision clinical care. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83265032/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83124768" class="text-dark hover-underline">Revised criteria for the diagnosis and staging of Alzheimer&#039;s disease</a> </h4> <p class="text-ellipsis-2">Clifford R. Jack Jr, Scott J. Andrews, Thomas G. Beach, Teresa Buracchio, Billy Dunn, Ana Graf, Oskar Hansson, Carole Ho, William Jagust, Eric McDade, Jose Luis Molinuevo, Ozioma C. Okonkwo, Luca Pani, Michael S. Rafii, Philip Scheltens, Eric Siemers, Heather M. Snyder, Reisa Sperling, Charlotte E. Teunissen, Maria C. Carrillo</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Alzheimer&#039;s disease can be treated and diagnosed, with treatment targeting amyloid-beta plaques and diagnosis relying on biomarkers, which prompts the revision of criteria for its diagnosis and staging. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83124768/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/84528274" class="text-dark hover-underline">Soft robotic apparel to avert freezing of gait in Parkinson&#039;s disease</a> </h4> <p class="text-ellipsis-2">Jinsoo Kim, Franchino Porciuncula, Hee Doo Yang, Nicholas Wendel, Teresa Baker, Andrew Chin, Terry D. Ellis, Conor J. Walsh</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study demonstrated the concept of using soft robotic apparel to avoid freezing of gait in Parkinson&#039;s disease. In an n-of-1 trial with a 73-year-old male patient, the robotic apparel eliminated FoG during indoor walking, increased walking distance, speed, and improved gait quality, with repeatable effects. This provides impetus for technological advancements. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/84528274/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83071529" class="text-dark hover-underline">Evaluation and mitigation of the limitations of large language models in clinical decision-making</a> </h4> <p class="text-ellipsis-2">Paul Hager, Friederike Jungmann, Robbie Holland, Kunal Bhagat, Inga Hubrecht, Manuel Knauer, Jakob Vielhauer, Marcus Makowski, Rickmer Braren, Georgios Kaissis, Daniel Rueckert</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study shows that although large language models perform well in medical licensing exams, they have many problems in the real clinical decision-making environment, such as inaccurate diagnosis of all diseases, non-compliance with guidelines, and inability to interpret laboratory results. Therefore, they are not currently suitable for autonomous clinical decision-making. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83071529/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/84527960" class="text-dark hover-underline">Association of semaglutide with risk of suicidal ideation in a real-world cohort</a> </h4> <p class="text-ellipsis-2">William Wang, Nora D. Volkow, Nathan A. Berger, Pamela B. Davis, David C. Kaelber, Rong Xu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study aimed to assess the associations of semaglutide with suicidal ideation compared to non-GLP1R agonist anti-obesity or anti-diabetes medications. The results showed that in patients with overweight or obesity and T2DM, semaglutide was associated with a lower risk of incident and recurrent suicidal ideation, and the associations were consistent across sex, age, and ethnicity stratification. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/84527960/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83928426" class="text-dark hover-underline">Advancing global antibiotic research, development and access</a> </h4> <p class="text-ellipsis-2">Laura J. V. Piddock, Yewande Alimi, James Anderson, Damiano de Felice, Catrin E. Moore, John-Arne Rottingen, Henry Skinner, Peter Beyer</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Antibiotic R&amp;D is in trouble, with economic challenges reducing private investment and many countries facing a crisis of antibiotic shortages and unequal access. Public and philanthropic funds support antibiotic R&amp;D through partnerships, and the world&#039;s leaders need to increase their support to build a sustainable R&amp;D ecosystem and strategies to address antimicrobial resistance. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83928426/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemistry &amp; Molecular Biology </span> </div> <h4> <a href="https://www.peeref.com/works/83355931" class="text-dark hover-underline">Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations</a> </h4> <p class="text-ellipsis-2">M. Austin Argentieri, Sihao Xiao, Derrick Bennett, Laura Winchester, Alejo J. Nevado-Holgado, Upamanyu Ghose, Ashwag Albukhari, Pang Yao, Mohsen Mazidi, Jun Lv, Iona Millwood, Hannah Fry, Rodosthenis S. Rodosthenous, Jukka Partanen, Zhili Zheng, Mitja Kurki, Mark J. Daly, Aarno Palotie, Cassandra J. Adams, Liming Li, Robert Clarke, Najaf Amin, Zhengming Chen, Cornelia M. van Duijn</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A proteomic age clock was developed to predict biological age by analyzing plasma proteins, and it was found to be associated with the incidence of multiple chronic diseases, multimorbidity, and mortality risk. The clock showed similar accuracy in different populations and can be used to assess age-related functional status. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE MEDICINE</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/works/83355931/add-to-collection" target="_blank"> <strong>Add to Collection</strong> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="modal fade" id="export-citation" tabindex="-1"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal"><span>&times;</span></button> <h4 class="modal-title">Export Citation <b class="text-primary"></b></h4> </div> <div class="modal-body"> <div class="my-3 px-4 f16"> <form action="https://www.peeref.com/works/citation/download" method="GET" target="_blank"> <div class="radio"> 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