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Tomić</title> <meta name="description" content="Search results for: Sanja Tomić"> <meta name="keywords" content="Sanja Tomić"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Sanja Tomić"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 56</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Sanja Tomić</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">56</span> Predictors of Social Participation of Children with Cerebral Palsy in Primary Schools in Czech Republic</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marija%20Zuli%C4%87">Marija Zulić</a>, <a href="https://publications.waset.org/abstracts/search?q=Vanda%20H%C3%A1jkov%C3%A1"> Vanda Hájková</a>, <a href="https://publications.waset.org/abstracts/search?q=Nina%20Brki%C4%87-Jovanovi%C4%87"> Nina Brkić-Jovanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Linda%20Rathousov%C3%A1"> Linda Rathousová</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Tomi%C4%87"> Sanja Tomić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cerebral palsy is primarily reflected in the disorder of the development of movement and posture, which may be accompanied by sensory disturbances, disturbances of perception, cognition and communication, behavioural disorders and epilepsy. According to current inclusive attitudes towards people with disabilities implies that full social participation of children with cerebral palsy means inclusion in all activities in family, peer, school and leisure environments in the same scope and to the same extent as is the case with the children of proper development and without physical difficulties. Due to the fact that it has been established that the quality of children's participation in primary school is directly related to their social inclusion in future life, the aim of the paper is to identify predictors of social participation, respectively, and in particular, factors that could to improve the quality of social participation of children with cerebral palsy, in the primary school environment in Czech Republic. The study includes children with cerebral palsy (n = 75) in the Czech Republic, aged between six and 12 years who attend mainstream or special primary schools to the sixth grade. The main instrument used was the first and third part of the School function assessment questionnaire. It will also take into account the type of damage assessed according to a scale the Gross motor function classification system, five–level classification system for cerebral palsy. The research results will provide detailed insight into the degree of social participation of children with cerebral palsy and the factors that would be a potential cause of their levels of participation, in regular and special primary schools, in different socioeconomic environments in Czech Republic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cerebral%20palsy" title="cerebral palsy">cerebral palsy</a>, <a href="https://publications.waset.org/abstracts/search?q=Czech%20republic" title=" Czech republic"> Czech republic</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20participation" title=" social participation"> social participation</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20school%20function%20assessment" title=" the school function assessment"> the school function assessment</a> </p> <a href="https://publications.waset.org/abstracts/67841/predictors-of-social-participation-of-children-with-cerebral-palsy-in-primary-schools-in-czech-republic" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67841.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">361</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">55</span> Speech Disorders as Predictors of Social Participation of Children with Cerebral Palsy in the Primary Schools of the Czech Republic</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marija%20Zuli%C4%87">Marija Zulić</a>, <a href="https://publications.waset.org/abstracts/search?q=Vanda%20H%C3%A1jkov%C3%A1"> Vanda Hájková</a>, <a href="https://publications.waset.org/abstracts/search?q=Nina%20Brki%C4%87%E2%80%93Jovanovi%C4%87"> Nina Brkić–Jovanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Sre%C4%87ko%20Poti%C4%87"> Srećko Potić</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Tomi%C4%87"> Sanja Tomić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The name cerebral palsy comes from the word cerebrum, which means the brain and the word palsy, which means seizure, and essentially refers to the movement disorder. In the clinical picture of cerebral palsy, basic neuromotor disorders are associated with other various disorders: behavioural, intellectual, speech, sensory, epileptic seizures, and bone and joint deformities. Motor speech disorders are among the most common difficulties present in people with cerebral palsy. Social participation represents an interaction between an individual and their social environment. Quality of social participation of the students with cerebral palsy at school is an important indicator of their successful participation in adulthood. One of the most important skills for the undisturbed social participation is ability of good communication. The aim of the study was to determine relation between social participation of students with cerebral palsy and presence of their speech impairment in primary schools in the Czech Republic. The study was performed in the Czech Republic in mainstream schools and schools established for the pupils with special education needs. We analysed 75 children with cerebral palsy aged between six and twelve years attending up to sixth grade by using the first and the third part of the school function assessment questionnaire as the main instrument. The other instrument we used in the research is the Gross motor function classification system–five–level classification system, which measures degree of motor functions of children and youth with cerebral palsy. Funding for this study was provided by the Grant Agency of Charles University in Prague. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cerebral%20palsy" title="cerebral palsy">cerebral palsy</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20participation" title=" social participation"> social participation</a>, <a href="https://publications.waset.org/abstracts/search?q=speech%20disorders" title=" speech disorders"> speech disorders</a>, <a href="https://publications.waset.org/abstracts/search?q=The%20Czech%20Republic" title=" The Czech Republic"> The Czech Republic</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20school%20function%20assessment" title=" the school function assessment"> the school function assessment</a> </p> <a href="https://publications.waset.org/abstracts/76883/speech-disorders-as-predictors-of-social-participation-of-children-with-cerebral-palsy-in-the-primary-schools-of-the-czech-republic" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76883.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">285</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">54</span> Cybersecurity Awareness Among Applied Sciences Student Population</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Bracun">Sanja Bracun</a>, <a href="https://publications.waset.org/abstracts/search?q=Nikolina%20Kasunic"> Nikolina Kasunic</a> </p> <p class="card-text"><strong>Abstract:</strong></p> After graduation, the student population of applied sciences will become the population of employees on IT experts’ positions or "just" business users of certain IT technologies for which the level of awareness of existing cybersecurity risks is extremely important. This research results define the current cybersecurity awareness level of students at Zagreb University of Applied Sciences (TVZ), what can be useful not only for teaching staff to form a curriculum related to cybersecurity more accurately but also to employers to know what to expect from their future employees regarding cybersecurity awareness level. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=student%20population%20cybersecurity%20awareness" title="student population cybersecurity awareness">student population cybersecurity awareness</a>, <a href="https://publications.waset.org/abstracts/search?q=cybersecurity%20awareness" title=" cybersecurity awareness"> cybersecurity awareness</a>, <a href="https://publications.waset.org/abstracts/search?q=cybersecurity" title=" cybersecurity"> cybersecurity</a>, <a href="https://publications.waset.org/abstracts/search?q=applied%20sciences%20students" title=" applied sciences students"> applied sciences students</a> </p> <a href="https://publications.waset.org/abstracts/150938/cybersecurity-awareness-among-applied-sciences-student-population" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150938.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">254</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">53</span> Chemometric QSRR Evaluation of Behavior of s-Triazine Pesticides in Liquid Chromatography</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87">Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac-Kuzmanovi%C4%87"> Sanja O. Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87"> Strahinja Z. Kovačević</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study considers the selection of the most suitable in silico molecular descriptors that could be used for s-triazine pesticides characterization. Suitable descriptors among topological, geometrical and physicochemical are used for quantitative structure-retention relationships (QSRR) model establishment. Established models were obtained using linear regression (LR) and multiple linear regression (MLR) analysis. In this paper, MLR models were established avoiding multicollinearity among the selected molecular descriptors. Statistical quality of established models was evaluated by standard and cross-validation statistical parameters. For detection of similarity or dissimilarity among investigated s-triazine pesticides and their classification, principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used and gave similar grouping. This study is financially supported by COST action TD1305. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemometrics" title="chemometrics">chemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=classification%20analysis" title=" classification analysis"> classification analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20descriptors" title=" molecular descriptors"> molecular descriptors</a>, <a href="https://publications.waset.org/abstracts/search?q=pesticides" title=" pesticides"> pesticides</a>, <a href="https://publications.waset.org/abstracts/search?q=regression%20analysis" title=" regression analysis "> regression analysis </a> </p> <a href="https://publications.waset.org/abstracts/45198/chemometric-qsrr-evaluation-of-behavior-of-s-triazine-pesticides-in-liquid-chromatography" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45198.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">393</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">52</span> Chemometric Estimation of Inhibitory Activity of Benzimidazole Derivatives by Linear Least Squares and Artificial Neural Networks Modelling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac-Kuzmanovi%C4%87"> Sanja O. Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87"> Strahinja Z. Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87"> Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Stela%20Joki%C4%87"> Stela Jokić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The subject of this paper is to correlate antibacterial behavior of benzimidazole derivatives with their molecular characteristics using chemometric QSAR (Quantitative Structure–Activity Relationships) approach. QSAR analysis has been carried out on the inhibitory activity of benzimidazole derivatives against Staphylococcus aureus. The data were processed by linear least squares (LLS) and artificial neural network (ANN) procedures. The LLS mathematical models have been developed as a calibration models for prediction of the inhibitory activity. The quality of the models was validated by leave one out (LOO) technique and by using external data set. High agreement between experimental and predicted inhibitory acivities indicated the good quality of the derived models. These results are part of the CMST COST Action No. CM1306 "Understanding Movement and Mechanism in Molecular Machines". <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Antibacterial" title="Antibacterial">Antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=benzimidazoles" title=" benzimidazoles"> benzimidazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=chemometric" title=" chemometric"> chemometric</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR." title=" QSAR."> QSAR.</a> </p> <a href="https://publications.waset.org/abstracts/32354/chemometric-estimation-of-inhibitory-activity-of-benzimidazole-derivatives-by-linear-least-squares-and-artificial-neural-networks-modelling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32354.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">51</span> Relations among Coping with Stress, Anxiety and the Achievement Motive of Athletes and Non-Athletes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dragana%20Tomic">Dragana Tomic</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research deals with relations among strategies and styles of coping with stress, social interaction anxiety and the achievement motive of young athletes and non-athletes. The research was conducted on the sample of 402 examinees (197 female and 205 male participants) of the average age of 20.76, divided into three groups: athletes, recreationists, and non-athletes. The COPE-S questionnaire, the Social Interaction Anxiety Scale (SIAS) and the Achievement Motivation Questionnaire (MOP 2002) were used for conducting this research and they had satisfactory reliability. The results of the research indicate that athletes, recreationists and non-athletes are not different when it comes to strategies and styles of coping with stress. Non- athletes have more noticeable social interaction anxiety when compared to athletes (U=5281.5, p=.000) and also when compared to recreationists (U=7573, p=.000). There was a difference among these three groups in the achievement motive (χ2(2)=23,544, p=.000) and the three components of this motive (Competing with others, χ2(2)=31,718, p=.000, Perseverance, χ2(2)=9,415, p=.009 and Planning orientation, χ2(2)=8,171, p=.017). The research also indicates a significant difference in the relation between social interaction anxiety and the achievement motive of examinee subgroups, where the most significant difference is between athletes and non- athletes (q=-.45). Moreover, women more frequently use emotion-focused coping (U=16718, p=.003), while men more frequently use avoidance (U=14895.5, p=.000). Women have a lead when it comes to expressing social anxiety (U=17750.5, p=.036) and the achievement motive (U=17395.5, p=.020). The discussion of the results includes findings of similar previous research and theoretical concepts of the variables which were examined. Future research should be oriented towards examining the background of the differences which were (not) gained as well as towards the influence of personality dimensions on the variables which were examined in order to apply the results in practice in the best way. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=achievement%20motivation" title="achievement motivation">achievement motivation</a>, <a href="https://publications.waset.org/abstracts/search?q=athletes" title=" athletes"> athletes</a>, <a href="https://publications.waset.org/abstracts/search?q=coping%20with%20stress" title=" coping with stress"> coping with stress</a>, <a href="https://publications.waset.org/abstracts/search?q=non-athletes" title=" non-athletes"> non-athletes</a>, <a href="https://publications.waset.org/abstracts/search?q=recreationists" title=" recreationists"> recreationists</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20interaction%20anxiety" title=" social interaction anxiety"> social interaction anxiety</a> </p> <a href="https://publications.waset.org/abstracts/85173/relations-among-coping-with-stress-anxiety-and-the-achievement-motive-of-athletes-and-non-athletes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85173.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">50</span> Differences in Innovative Orientation of the Entrepreneurially Active Adults: The Case of Croatia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nata%C5%A1a%20%C5%A0arlija">Nataša Šarlija</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Pfeifer"> Sanja Pfeifer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study analyzes the innovative orientation of the Croatian entrepreneurs. Innovative orientation is represented by the perceived extent to which an entrepreneur’s product or service or technology is new, and no other businesses offer the same product. The sample is extracted from the GEM Croatia Adult Population Survey dataset for the years 2003-2013. We apply descriptive statistics, t-test, Chi-square test and logistic regression. Findings indicate that innovative orientations vary with personal, firm, meso and macro level variables, and between different stages in entrepreneurship process. Significant predictors are occupation of the entrepreneurs, size of the firm and export aspiration for both early stage and established entrepreneurs. In addition, fear of failure, expecting to start a new business and seeing an entrepreneurial career as a desirable choice are predictors of innovative orientation among early stage entrepreneurs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multilevel%20determinants%20of%20the%20innovative%20orientation" title="multilevel determinants of the innovative orientation">multilevel determinants of the innovative orientation</a>, <a href="https://publications.waset.org/abstracts/search?q=Croatian%20early%20stage%20entrepreneurs" title=" Croatian early stage entrepreneurs"> Croatian early stage entrepreneurs</a>, <a href="https://publications.waset.org/abstracts/search?q=established%20businesses" title=" established businesses"> established businesses</a>, <a href="https://publications.waset.org/abstracts/search?q=GEM%20evidence" title=" GEM evidence "> GEM evidence </a> </p> <a href="https://publications.waset.org/abstracts/18024/differences-in-innovative-orientation-of-the-entrepreneurially-active-adults-the-case-of-croatia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18024.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">498</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">49</span> Chemometric Estimation of Phytochemicals Affecting the Antioxidant Potential of Lettuce</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Milica%20Karadzic">Milica Karadzic</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevric"> Lidija Jevric</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovic"> Sanja Podunavac-Kuzmanovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kovacevic"> Strahinja Kovacevic</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandra%20Tepic-Horecki"> Aleksandra Tepic-Horecki</a>, <a href="https://publications.waset.org/abstracts/search?q=Zdravko%20Sumic"> Zdravko Sumic</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, the influence of six different phytochemical content (phenols, carotenoids, chlorophyll a, chlorophyll b, chlorophyll a + b and vitamin C) on antioxidant potential of Murai and Levistro lettuce varieties was evaluated. Variable selection was made by generalized pair correlation method (GPCM) as a novel ranking method. This method is used for the discrimination between two variables that almost equal correlate to a dependent variable. Fisher’s conditional exact and McNemar’s test were carried out. Established multiple linear (MLR) models were statistically evaluated. As the best phytochemicals for the antioxidant potential prediction, chlorophyll a, chlorophyll a + b and total carotenoids content stand out. This was confirmed through both GPCM and MLR, predictive ability of obtained MLR can be used for antioxidant potential estimation for similar lettuce samples. This article is based upon work from the project of the Provincial Secretariat for Science and Technological Development of Vojvodina (No. 114-451-347/2015-02). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title="antioxidant activity">antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=generalized%20pair%20correlation%20method" title=" generalized pair correlation method"> generalized pair correlation method</a>, <a href="https://publications.waset.org/abstracts/search?q=lettuce" title=" lettuce"> lettuce</a>, <a href="https://publications.waset.org/abstracts/search?q=regression%20analysis" title=" regression analysis"> regression analysis</a> </p> <a href="https://publications.waset.org/abstracts/50586/chemometric-estimation-of-phytochemicals-affecting-the-antioxidant-potential-of-lettuce" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50586.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">388</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">48</span> Application of Artificial Neural Network for Prediction of Retention Times of Some Secoestrane Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nata%C5%A1a%20Kalajd%C5%BEija">Nataša Kalajdžija</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87"> Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Davor%20Lon%C4%8Dar"> Davor Lončar</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac%20Kuzmanovi%C4%87"> Sanja Podunavac Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In order to investigate the relationship between retention and structure, a quantitative Structure Retention Relationships (QSRRs) study was applied for the prediction of retention times of a set of 23 secoestrane derivatives in a reversed-phase thin-layer chromatography. After the calculation of molecular descriptors, a suitable set of molecular descriptors was selected by using step-wise multiple linear regressions. Artificial Neural Network (ANN) method was employed to model the nonlinear structure-activity relationships. The ANN technique resulted in 5-6-1 ANN model with the correlation coefficient of 0.98. We found that the following descriptors: Critical pressure, total energy, protease inhibition, distribution coefficient (LogD) and parameter of lipophilicity (miLogP) have a significant effect on the retention times. The prediction results are in very good agreement with the experimental ones. This approach provided a new and effective method for predicting the chromatographic retention index for the secoestrane derivatives investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lipophilicity" title="lipophilicity">lipophilicity</a>, <a href="https://publications.waset.org/abstracts/search?q=QSRR" title=" QSRR"> QSRR</a>, <a href="https://publications.waset.org/abstracts/search?q=RP%20TLC%20retention" title=" RP TLC retention"> RP TLC retention</a>, <a href="https://publications.waset.org/abstracts/search?q=secoestranes" title=" secoestranes"> secoestranes</a> </p> <a href="https://publications.waset.org/abstracts/2743/application-of-artificial-neural-network-for-prediction-of-retention-times-of-some-secoestrane-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2743.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">457</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">47</span> Combined Automatic Speech Recognition and Machine Translation in Business Correspondence Domain for English-Croatian</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Seljan">Sanja Seljan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivan%20Dun%C4%91er"> Ivan Dunđer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The paper presents combined automatic speech recognition (ASR) for English and machine translation (MT) for English and Croatian in the domain of business correspondence. The first part presents results of training the ASR commercial system on two English data sets, enriched by error analysis. The second part presents results of machine translation performed by online tool Google Translate for English and Croatian and Croatian-English language pairs. Human evaluation in terms of usability is conducted and internal consistency calculated by Cronbach's alpha coefficient, enriched by error analysis. Automatic evaluation is performed by WER (Word Error Rate) and PER (Position-independent word Error Rate) metrics, followed by investigation of Pearson’s correlation with human evaluation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=automatic%20machine%20translation" title="automatic machine translation">automatic machine translation</a>, <a href="https://publications.waset.org/abstracts/search?q=integrated%20language%20technologies" title=" integrated language technologies"> integrated language technologies</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20evaluation" title=" quality evaluation"> quality evaluation</a>, <a href="https://publications.waset.org/abstracts/search?q=speech%20recognition" title=" speech recognition"> speech recognition</a> </p> <a href="https://publications.waset.org/abstracts/11845/combined-automatic-speech-recognition-and-machine-translation-in-business-correspondence-domain-for-english-croatian" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/11845.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">484</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">46</span> Hierarchical Cluster Analysis of Raw Milk Samples Obtained from Organic and Conventional Dairy Farming in Autonomous Province of Vojvodina, Serbia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87">Lidija Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Denis%20Ku%C4%8Devi%C4%87"> Denis Kučević</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovi%C4%87"> Sanja Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87"> Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Milica%20Karad%C5%BEi%C4%87"> Milica Karadžić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, the Hierarchical Cluster Analysis (HCA) was applied in order to determine the differences between the milk samples originating from a conventional dairy farm (CF) and an organic dairy farm (OF) in AP Vojvodina, Republic of Serbia. The clustering was based on the basis of the average values of saturated fatty acids (SFA) content and unsaturated fatty acids (UFA) content obtained for every season. Therefore, the HCA included the annual SFA and UFA content values. The clustering procedure was carried out on the basis of Euclidean distances and Single linkage algorithm. The obtained dendrograms indicated that the clustering of UFA in OF was much more uniform compared to clustering of UFA in CF. In OF, spring stands out from the other months of the year. The same case can be noticed for CF, where winter is separated from the other months. The results could be expected because the composition of fatty acids content is greatly influenced by the season and nutrition of dairy cows during the year. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemometrics" title="chemometrics">chemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=clustering" title=" clustering"> clustering</a>, <a href="https://publications.waset.org/abstracts/search?q=food%20engineering" title=" food engineering"> food engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=milk%20quality" title=" milk quality"> milk quality</a> </p> <a href="https://publications.waset.org/abstracts/74573/hierarchical-cluster-analysis-of-raw-milk-samples-obtained-from-organic-and-conventional-dairy-farming-in-autonomous-province-of-vojvodina-serbia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/74573.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">281</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">45</span> Digital Mapping as a Tool for Finding Cities' DNA</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Peter">Sanja Peter</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Transformation of urban environments can be compared to evolutionary processes. Systematic digital mapping of historical data can enable capturing some of these processes and their outcomes. For example, it may help reveal the structure of a city’s historical DNA. Gathering historical data for automatic processing may be giving a basis for cultural algorithms. Gothenburg City museum is trying to make city’s heritage information accessible through GIS-platforms and is now partnering with academic institutions to find appropriate methods to make accessible the knowledge on the city’s historical fabric. Hopefully, this will be carried out through a project called Digital Twin Cities. One part of this large project, concerning matters of Cultural Heritage, will be in collaboration with Chalmers University of Technology. The aim is to create a layered map showing historical developments of the city and extracting quantitative data about its built heritage, above and below the earth. It will allow interpreting the information from historic maps through, for example, names of the streets/places, geography, structural changes in urban fabric and information gathered by archaeologists’ excavations. Through the study of these geographical, historical and local metamorphoses, urban environment will reveal its metaphorical DNA or its MEM (Dawkins). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gothenburg" title="Gothenburg">Gothenburg</a>, <a href="https://publications.waset.org/abstracts/search?q=mapping" title=" mapping"> mapping</a>, <a href="https://publications.waset.org/abstracts/search?q=cultural%20heritage" title=" cultural heritage"> cultural heritage</a>, <a href="https://publications.waset.org/abstracts/search?q=city%20history" title=" city history"> city history</a> </p> <a href="https://publications.waset.org/abstracts/106822/digital-mapping-as-a-tool-for-finding-cities-dna" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106822.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">140</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">44</span> Multi-Faceted Growth in Creative Industries </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Pfeifer">Sanja Pfeifer</a>, <a href="https://publications.waset.org/abstracts/search?q=Nata%C5%A1a%20%C5%A0arlija"> Nataša Šarlija</a>, <a href="https://publications.waset.org/abstracts/search?q=Marina%20Jeger"> Marina Jeger</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Biland%C5%BEi%C4%87"> Ana Bilandžić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of this study is to explore the different facets of growth among micro, small and medium-sized firms in Croatia and to analyze the differences between models designed for <em>all</em> micro, small and medium-sized firms and those in <em>creative</em> industries. Three growth prediction models were designed and tested using the growth of sales, employment and assets of the company as dependent variables. The key drivers of sales growth are: prudent use of cash, industry affiliation and higher share of intangible assets. Growth of assets depends on retained profits, internal and external sources of financing, as well as industry affiliation. Growth in employment is closely related to sources of financing, in particular, debt and it occurs less frequently than growth in sales and assets. The findings confirm the assumption that growth strategies of small and medium-sized enterprises (SMEs) in creative industries have specific differences in comparison to SMEs in general. Interestingly, only 2.2% of growing enterprises achieve growth in employment, assets and sales simultaneously. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=creative%20industries" title="creative industries">creative industries</a>, <a href="https://publications.waset.org/abstracts/search?q=growth%20prediction%20model" title=" growth prediction model"> growth prediction model</a>, <a href="https://publications.waset.org/abstracts/search?q=growth%20determinants" title=" growth determinants"> growth determinants</a>, <a href="https://publications.waset.org/abstracts/search?q=growth%20measures" title=" growth measures"> growth measures</a> </p> <a href="https://publications.waset.org/abstracts/43741/multi-faceted-growth-in-creative-industries" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43741.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">332</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">43</span> Evaluation of QSRR Models by Sum of Ranking Differences Approach: A Case Study of Prediction of Chromatographic Behavior of Pesticides</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87">Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac-Kuzmanovi%C4%87"> Sanja O. Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87"> Strahinja Z. Kovačević</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study deals with the selection of the most suitable quantitative structure-retention relationship (QSRR) models which should be used in prediction of the retention behavior of basic, neutral, acidic and phenolic pesticides which belong to different classes: fungicides, herbicides, metabolites, insecticides and plant growth regulators. Sum of ranking differences (SRD) approach can give a different point of view on selection of the most consistent QSRR model. SRD approach can be applied not only for ranking of the QSRR models, but also for detection of similarity or dissimilarity among them. Applying the SRD analysis, the most similar models can be found easily. In this study, selection of the best model was carried out on the basis of the reference ranking (“golden standard”) which was defined as the row average values of logarithm of retention time (logtr) defined by high performance liquid chromatography (HPLC). Also, SRD analysis based on experimental logtr values as reference ranking revealed similar grouping of the established QSRR models already obtained by hierarchical cluster analysis (HCA). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemometrics" title="chemometrics">chemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=chromatography" title=" chromatography"> chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=pesticides" title=" pesticides"> pesticides</a>, <a href="https://publications.waset.org/abstracts/search?q=sum%20of%20ranking%20differences" title=" sum of ranking differences"> sum of ranking differences</a> </p> <a href="https://publications.waset.org/abstracts/41801/evaluation-of-qsrr-models-by-sum-of-ranking-differences-approach-a-case-study-of-prediction-of-chromatographic-behavior-of-pesticides" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41801.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">42</span> Artificial Neural Network Regression Modelling of GC/MS Retention of Terpenes Present in Satureja montana Extracts Obtained by Supercritical Carbon Dioxide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87">Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Jelena%20Vladi%C4%87"> Jelena Vladić</a>, <a href="https://publications.waset.org/abstracts/search?q=Senka%20Vidovi%C4%87"> Senka Vidović</a>, <a href="https://publications.waset.org/abstracts/search?q=Zoran%20Zekovi%C4%87"> Zoran Zeković</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac%20Kuzmanovi%C4%87"> Sanja Podunavac Kuzmanović</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Supercritical extracts of highly valuated medicinal plant Satureja montana were prepared by application of supercritical carbon dioxide extraction in the carbon dioxide pressure range from 125 to 350 bar and temperature range from 40 to 60°C. Using GC/MS method of analysis chemical profiles (aromatic constituents) of S. montana extracts were obtained. Self-training artificial neural networks were applied to predict the retention time of the analyzed terpenes in GC/MS system. The best ANN model obtained was multilayer perceptron (MLP 11-11-1). Hidden activation was tanh and output activation was identity with Broyden–Fletcher–Goldfarb–Shanno training algorithm. Correlation measures of the obtained network were the following: R(training) = 0.9975, R(test) = 0.9971 and R(validation) = 0.9999. The comparison of the experimental and predicted retention times of the analyzed compounds showed very high correlation (R = 0.9913) and significant predictive power of the established neural network. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ANN%20regression" title="ANN regression">ANN regression</a>, <a href="https://publications.waset.org/abstracts/search?q=GC%2FMS" title=" GC/MS"> GC/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=Satureja%20montana" title=" Satureja montana"> Satureja montana</a>, <a href="https://publications.waset.org/abstracts/search?q=terpenes" title=" terpenes"> terpenes</a> </p> <a href="https://publications.waset.org/abstracts/2742/artificial-neural-network-regression-modelling-of-gcms-retention-of-terpenes-present-in-satureja-montana-extracts-obtained-by-supercritical-carbon-dioxide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2742.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">452</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">41</span> In Silico Design of Organometallic Complexes as Potential Antibacterial Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac-Kuzmanovi%C4%87">Sanja O. Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87"> Strahinja Z. Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87"> Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Stela%20Joki%C4%87"> Stela Jokić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The complexes of transition metals with various organic ligands have been extensively studied as models of some important pharmaceutical molecules. It was found that biological properties of different substituted organic molecules are improved when they are complexed by different metals. Therefore, it is of great importance for the development of coordination chemistry to explore the assembly of functional organic ligands with metal ion and to investigate the relationship between the structure and property. In the present work, we have bioassayed the antibacterial potency of benzimidazoles and their metal salts (Cu or Zn) against yeast Sarcina lutea. In order to validate our in vitro study, we performed in silico studies using molecular docking software. The investigated compounds and their metal complexes (Cu, Zn) showed good to moderate inhibitory activity against Sarcina lutea. In silico docking studies of the synthesized compounds suggested that complexed benzimidazoles have a greater binding affinity and improved antibacterial activity in comparison with non-complexed ligands. These results are part of the CMST COST Action No. 1105 "Functional metal complexes that bind to biomolecules". <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=organometallic%20complexes" title="organometallic complexes">organometallic complexes</a>, <a href="https://publications.waset.org/abstracts/search?q=benzimidazoles" title=" benzimidazoles"> benzimidazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=chemometric%20design" title=" chemometric design"> chemometric design</a>, <a href="https://publications.waset.org/abstracts/search?q=Sarcina%20lutea" title=" Sarcina lutea "> Sarcina lutea </a> </p> <a href="https://publications.waset.org/abstracts/32233/in-silico-design-of-organometallic-complexes-as-potential-antibacterial-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32233.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">343</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">40</span> Computational Study of Chromatographic Behavior of a Series of S-Triazine Pesticides Based on Their in Silico Biological and Lipophilicity Descriptors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87">Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac-Kuzmanovi%C4%87"> Sanja O. Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87"> Strahinja Z. Kovačević</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, quantitative structure-retention relationships (QSRR) analysis was applied in order to correlate in silico biological and lipophilicity molecular descriptors with retention values for the set of selected s-triazine herbicides. In silico generated biological and lipophilicity descriptors were discriminated using generalized pair correlation method (GPCM). According to this method, the significant difference between independent variables can be noticed regardless almost equal correlation with dependent variable. Using established multiple linear regression (MLR) models some biological characteristics could be predicted. Established MLR models were evaluated statistically and the most suitable models were selected and ranked using sum of ranking differences (SRD) method. In this method, as reference values, average experimentally obtained values are used. Additionally, using SRD method, similarities among investigated s-triazine herbicides can be noticed. These analysis were conducted in order to characterize selected s-triazine herbicides for future investigations regarding their biodegradability. This study is financially supported by COST action TD1305. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=descriptors" title="descriptors">descriptors</a>, <a href="https://publications.waset.org/abstracts/search?q=generalized%20pair%20correlation%20method" title=" generalized pair correlation method"> generalized pair correlation method</a>, <a href="https://publications.waset.org/abstracts/search?q=pesticides" title=" pesticides"> pesticides</a>, <a href="https://publications.waset.org/abstracts/search?q=sum%20of%20ranking%20differences" title=" sum of ranking differences "> sum of ranking differences </a> </p> <a href="https://publications.waset.org/abstracts/45126/computational-study-of-chromatographic-behavior-of-a-series-of-s-triazine-pesticides-based-on-their-in-silico-biological-and-lipophilicity-descriptors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45126.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">39</span> Enhanced Decolourization and Biodegradation of Textile Azo and Xanthene Dyes by Using Bacterial Isolates </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gimhani%20Madhushika%20Hewayalage">Gimhani Madhushika Hewayalage</a>, <a href="https://publications.waset.org/abstracts/search?q=Thilini%20Ariyadasa"> Thilini Ariyadasa</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Gunawardena"> Sanja Gunawardena</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In Sri Lanka, the largest contribution for the industrial export earnings is governed by textile and apparel industry. However, this industry generates huge quantities of effluent consists of unfixed dyes which enhance the effluent colour and toxicity thereby leading towards environmental pollution. Therefore, the effluent should properly be treated prior to the release into the environment. The biological technique has now captured much attention as an environmental-friendly and cost-competitive effluent decolourization method due to the drawbacks of physical and chemical treatment techniques. The present study has focused on identifying dye decolourizing potential of several bacterial isolates obtained from the effluent of the local textile industry. Yellow EXF, Red EXF, Blue EXF, Nova Black WNN and Nylosan-Rhodamine-EB dyes have been selected for the study to represent different chromophore groups such as Azo and Xanthene. The rates of decolorization of each dye have been investigated by employing distinct bacterial isolates. Bacterial isolate which exhibited effective dye decolorizing potential was identified as Proteus mirabilis using 16S rRNA gene sequencing analysis. The high decolorizing rates of identified bacterial strain indicate its potential applicability in the treatment of dye-containing wastewaters. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=azo" title="azo">azo</a>, <a href="https://publications.waset.org/abstracts/search?q=bacterial" title=" bacterial"> bacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=biological" title=" biological"> biological</a>, <a href="https://publications.waset.org/abstracts/search?q=decolourization" title=" decolourization"> decolourization</a>, <a href="https://publications.waset.org/abstracts/search?q=xanthene" title=" xanthene"> xanthene</a> </p> <a href="https://publications.waset.org/abstracts/60653/enhanced-decolourization-and-biodegradation-of-textile-azo-and-xanthene-dyes-by-using-bacterial-isolates" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60653.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">252</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">38</span> Molecular Modeling of 17-Picolyl and 17-Picolinylidene Androstane Derivatives with Anticancer Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovi%C4%87">Sanja Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87"> Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Evgenija%20Djurendi%C4%87"> Evgenija Djurendić</a>, <a href="https://publications.waset.org/abstracts/search?q=Jovana%20Ajdukovi%C4%87"> Jovana Ajduković</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, the molecular modeling of a series of 24 17-picolyl and 17-picolinylidene androstane derivatives whit significant anticancer activity was carried out. Modelling of studied compounds was performed by CS ChemBioDraw Ultra v12.0 program for drawing 2D molecular structures and CS ChemBio3D Ultra v12.0 for 3D molecular modelling. The obtained 3D structures were subjected to energy minimization using molecular mechanics force field method (MM2). The cutoff for structure optimization was set at a gradient of 0.1 kcal/Åmol. Full geometry optimization was done by the Austin Model 1 (AM1) until the root mean square (RMS) gradient reached a value smaller than 0.0001 kcal/Åmol using Molecular Orbital Package (MOPAC) program. The obtained physicochemical, lipophilicity and topological descriptors were used for analysis of molecular similarities and dissimilarities applying suitable chemometric methods (principal component analysis and cluster analysis). These results are the part of the project No. 114-451-347/2015-02, financially supported by the Provincial Secretariat for Science and Technological Development of Vojvodina and CMST COST Action CM1306. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androstane%20derivatives" title="androstane derivatives">androstane derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=anticancer%20activity" title=" anticancer activity"> anticancer activity</a>, <a href="https://publications.waset.org/abstracts/search?q=chemometrics" title=" chemometrics"> chemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20descriptors" title=" molecular descriptors"> molecular descriptors</a> </p> <a href="https://publications.waset.org/abstracts/38072/molecular-modeling-of-17-picolyl-and-17-picolinylidene-androstane-derivatives-with-anticancer-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38072.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">361</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">37</span> Chromatographic Lipophilicity Determination of Newly Synthesized Steroid Derivatives for Further Biological Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Milica%20Z.%20Karadzic">Milica Z. Karadzic</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevric"> Lidija R. Jevric</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovic"> Sanja Podunavac-Kuzmanovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kovacevic"> Strahinja Z. Kovacevic</a>, <a href="https://publications.waset.org/abstracts/search?q=Anamarija%20I.%20Mandic"> Anamarija I. Mandic</a>, <a href="https://publications.waset.org/abstracts/search?q=Katarina%20Penov-Gasi"> Katarina Penov-Gasi</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrea%20R.%20Nikolic"> Andrea R. Nikolic</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandar%20M.%20Okljesa"> Aleksandar M. Okljesa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, a set of 29 newly synthesized steroid derivatives were investigated using reversed-phase high-performance liquid chromatography (RP-HPLC) as a first step in preselection of drug candidates. This analysis presents an experimental determination of chromatographic lipophilicity, and it was conducted to obtain physicochemical characterization of these molecules. As the most widely used bonded phases in RP-HPLC, octadecyl (C18) and octyl (C8) were used. Binary mixtures of water and acetonitrile or methanol were used as mobile phases. Obtained results were expressed as retention factor values logk and they were correlated with logP values. The results showed that both columns provide good estimations of the chromatographic lipophilicity of the molecules included in this study. This analysis was conducted in order to characterize newly synthesized steroid derivatives for further investigation regarding their antiproliferative and antimicrobial activity. This article is based upon work from COST Action (CM1306), supported by COST (European Cooperation in Science and Technology). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antiproliferative%20activity" title="antiproliferative activity">antiproliferative activity</a>, <a href="https://publications.waset.org/abstracts/search?q=chromatographic%20lipophilicity" title=" chromatographic lipophilicity"> chromatographic lipophilicity</a>, <a href="https://publications.waset.org/abstracts/search?q=liquid%20chromatography" title=" liquid chromatography"> liquid chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=steroids" title=" steroids"> steroids</a> </p> <a href="https://publications.waset.org/abstracts/49454/chromatographic-lipophilicity-determination-of-newly-synthesized-steroid-derivatives-for-further-biological-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49454.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">291</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">36</span> Analysis of Possible Draught Size of Container Vessels on the Lower Danube</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Todor%20Ba%C4%8Dkali%C4%87">Todor Bačkalić</a>, <a href="https://publications.waset.org/abstracts/search?q=Marinko%20Maslari%C4%87"> Marinko Maslarić</a>, <a href="https://publications.waset.org/abstracts/search?q=Milosav%20Georgijevi%C4%87"> Milosav Georgijević</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Boji%C4%87"> Sanja Bojić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Water transport could be the backbone of the future European combined transport system. The future transport policy in landlocked countries from the Danube Region has to be based on inland waterway transport (IWT). The development of the container transport on inland waterways depends directly on technical-exploitative characteristics of the network of inland waterways. Research of navigational abilities of inland waterways is the basic step in transport planning. The size of the vessel’s draught (T) is the limiting value in project tasks and it depends on the depth of the waterway. Navigation characteristics of rivers have to be determined as precise as possible, especially from the aspect of determination of the possible draught of vessels. This article outlines a rationale, why it is necessary to develop competence about infrastructure risk in water transport. Climate changes are evident and require special attention and global monitoring. Current risk assessment methods for Inland waterway transport just consider some dramatic events. We present a new method for the assessment of risk and vulnerability of inland waterway transport where river depth represents a crucial part. The analysis of water level changes in the lower Danube was done for two significant periods (1965-1979 and 1998-2012). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=container%20vessel" title="container vessel">container vessel</a>, <a href="https://publications.waset.org/abstracts/search?q=draught" title=" draught"> draught</a>, <a href="https://publications.waset.org/abstracts/search?q=probability" title=" probability"> probability</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20Danube" title=" the Danube"> the Danube</a> </p> <a href="https://publications.waset.org/abstracts/29846/analysis-of-possible-draught-size-of-container-vessels-on-the-lower-danube" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29846.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">461</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">35</span> Facility Data Model as Integration and Interoperability Platform</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nikola%20Tomasevic">Nikola Tomasevic</a>, <a href="https://publications.waset.org/abstracts/search?q=Marko%20Batic"> Marko Batic</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Vranes"> Sanja Vranes</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Emerging Semantic Web technologies can be seen as the next step in evolution of the intelligent facility management systems. Particularly, this considers increased usage of open source and/or standardized concepts for data classification and semantic interpretation. To deliver such facility management systems, providing the comprehensive integration and interoperability platform in from of the facility data model is a prerequisite. In this paper, one of the possible modelling approaches to provide such integrative facility data model which was based on the ontology modelling concept was presented. Complete ontology development process, starting from the input data acquisition, ontology concepts definition and finally ontology concepts population, was described. At the beginning, the core facility ontology was developed representing the generic facility infrastructure comprised of the common facility concepts relevant from the facility management perspective. To develop the data model of a specific facility infrastructure, first extension and then population of the core facility ontology was performed. For the development of the full-blown facility data models, Malpensa and Fiumicino airports in Italy, two major European air-traffic hubs, were chosen as a test-bed platform. Furthermore, the way how these ontology models supported the integration and interoperability of the overall airport energy management system was analyzed as well. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=airport%20ontology" title="airport ontology">airport ontology</a>, <a href="https://publications.waset.org/abstracts/search?q=energy%20management" title=" energy management"> energy management</a>, <a href="https://publications.waset.org/abstracts/search?q=facility%20data%20model" title=" facility data model"> facility data model</a>, <a href="https://publications.waset.org/abstracts/search?q=ontology%20modeling" title=" ontology modeling"> ontology modeling</a> </p> <a href="https://publications.waset.org/abstracts/21225/facility-data-model-as-integration-and-interoperability-platform" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21225.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">448</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">34</span> Forecasting Optimal Production Program Using Profitability Optimization by Genetic Algorithm and Neural Network</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Galal%20H.%20Senussi">Galal H. Senussi</a>, <a href="https://publications.waset.org/abstracts/search?q=Muamar%20Benisa"> Muamar Benisa</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Vasin"> Sanja Vasin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In our business field today, one of the most important issues for any enterprises is cost minimization and profit maximization. Second issue is how to develop a strong and capable model that is able to give us desired forecasting of these two issues. Many researches deal with these issues using different methods. In this study, we developed a model for multi-criteria production program optimization, integrated with Artificial Neural Network. The prediction of the production cost and profit per unit of a product, dealing with two obverse functions at same time can be extremely difficult, especially if there is a great amount of conflict information about production parameters. Feed-Forward Neural Networks are suitable for generalization, which means that the network will generate a proper output as a result to input it has never seen. Therefore, with small set of examples the network will adjust its weight coefficients so the input will generate a proper output. This essential characteristic is of the most important abilities enabling this network to be used in variety of problems spreading from engineering to finance etc. From our results as we will see later, Feed-Forward Neural Networks has a strong ability and capability to map inputs into desired outputs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=project%20profitability" title="project profitability">project profitability</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-objective%20optimization" title=" multi-objective optimization"> multi-objective optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20algorithm" title=" genetic algorithm"> genetic algorithm</a>, <a href="https://publications.waset.org/abstracts/search?q=Pareto%20set" title=" Pareto set"> Pareto set</a>, <a href="https://publications.waset.org/abstracts/search?q=neural%20networks" title=" neural networks"> neural networks</a> </p> <a href="https://publications.waset.org/abstracts/9868/forecasting-optimal-production-program-using-profitability-optimization-by-genetic-algorithm-and-neural-network" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9868.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">445</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">33</span> Chemometric Analysis of Raw Milk Quality Originating from Conventional and Organic Dairy Farming in AP Vojvodina, Serbia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovi%C4%87">Sanja Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Denis%20Ku%C4%8Devi%C4%87"> Denis Kučević</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87"> Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Milica%20Karad%C5%BEi%C4%87"> Milica Karadžić</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study describes the application of chemometric methods in analysis of milk samples which were collected in a conventional dairy farm and an organic dairy farm in AP Vojvodina, Republic of Serbia. The chemometric analysis included the application of univariate regression modeling and Analysis of Variance (ANOVA) method. The ANOVA was used in order to determine the differences in fatty acids content in the milk samples from conventional and organic farm. The results of the ANOVA testing indicate that there is a highly statistically significant difference between the content of fatty acid (saturated fatty acid vs. unsaturated fatty acids) in different dairy farming. Besides, the linear univariate models have been obtained as a result of modeling the linear relationships between the milk fat content and saturated fatty acids content, and the linear relationships between the milk fat content and unsaturated fatty acids content. The models obtained on the basis of the milk samples which originate from the organic farming are statistically better than the models based on the milk samples from conventional farming. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hemometrics" title="hemometrics">hemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=milk" title=" milk"> milk</a>, <a href="https://publications.waset.org/abstracts/search?q=organic%20farming" title=" organic farming"> organic farming</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20control" title=" quality control"> quality control</a> </p> <a href="https://publications.waset.org/abstracts/74572/chemometric-analysis-of-raw-milk-quality-originating-from-conventional-and-organic-dairy-farming-in-ap-vojvodina-serbia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/74572.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">237</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">32</span> Quantitative Structure–Activity Relationship Analysis of Some Benzimidazole Derivatives by Linear Multivariate Method</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87">Strahinja Z. Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87"> Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac%20Kuzmanovi%C4%87"> Sanja O. Podunavac Kuzmanović</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The relationship between antibacterial activity of eighteen different substituted benzimidazole derivatives and their molecular characteristics was studied using chemometric QSAR (Quantitative Structure–Activity Relationships) approach. QSAR analysis has been carried out on inhibitory activity towards Staphylococcus aureus, by using molecular descriptors, as well as minimal inhibitory activity (MIC). Molecular descriptors were calculated from the optimized structures. Principal component analysis (PCA) followed by hierarchical cluster analysis (HCA) and multiple linear regression (MLR) was performed in order to select molecular descriptors that best describe the antibacterial behavior of the compounds investigated, and to determine the similarities between molecules. The HCA grouped the molecules in separated clusters which have the similar inhibitory activity. PCA showed very similar classification of molecules as the HCA, and displayed which descriptors contribute to that classification. MLR equations, that represent MIC as a function of the in silico molecular descriptors were established. The statistical significance of the estimated models was confirmed by standard statistical measures and cross-validation parameters (SD = 0.0816, F = 46.27, R = 0.9791, R2CV = 0.8266, R2adj = 0.9379, PRESS = 0.1116). These parameters indicate the possibility of application of the established chemometric models in prediction of the antibacterial behaviour of studied derivatives and structurally very similar compounds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title="antibacterial">antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=benzimidazole" title=" benzimidazole"> benzimidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20descriptors" title=" molecular descriptors"> molecular descriptors</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a> </p> <a href="https://publications.waset.org/abstracts/26542/quantitative-structure-activity-relationship-analysis-of-some-benzimidazole-derivatives-by-linear-multivariate-method" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26542.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">364</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">31</span> QSRR Analysis of 17-Picolyl and 17-Picolinylidene Androstane Derivatives Based on Partial Least Squares and Principal Component Regression</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovi%C4%87">Sanja Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87"> Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Evgenija%20Djurendi%C4%87"> Evgenija Djurendić</a>, <a href="https://publications.waset.org/abstracts/search?q=Jovana%20Ajdukovi%C4%87"> Jovana Ajduković</a> </p> <p class="card-text"><strong>Abstract:</strong></p> There are several methods for determination of the lipophilicity of biologically active compounds, however chromatography has been shown as a very suitable method for this purpose. Chromatographic (C18-RP-HPLC) analysis of a series of 24 17-picolyl and 17-picolinylidene androstane derivatives was carried out. The obtained retention indices (logk, methanol (90%) / water (10%)) were correlated with calculated physicochemical and lipophilicity descriptors. The QSRR analysis was carried out applying principal component regression (PCR) and partial least squares regression (PLS). The PCR and PLS model were selected on the basis of the highest variance and the lowest root mean square error of cross-validation. The obtained PCR and PLS model successfully correlate the calculated molecular descriptors with logk parameter indicating the significance of the lipophilicity of compounds in chromatographic process. On the basis of the obtained results it can be concluded that the obtained logk parameters of the analyzed androstane derivatives can be considered as their chromatographic lipophilicity. These results are the part of the project No. 114-451-347/2015-02, financially supported by the Provincial Secretariat for Science and Technological Development of Vojvodina and CMST COST Action CM1105. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=androstane%20derivatives" title="androstane derivatives">androstane derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=chromatography" title=" chromatography"> chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20structure" title=" molecular structure"> molecular structure</a>, <a href="https://publications.waset.org/abstracts/search?q=principal%20component%20regression" title=" principal component regression"> principal component regression</a>, <a href="https://publications.waset.org/abstracts/search?q=partial%20least%20squares%20regression" title=" partial least squares regression"> partial least squares regression</a> </p> <a href="https://publications.waset.org/abstracts/38073/qsrr-analysis-of-17-picolyl-and-17-picolinylidene-androstane-derivatives-based-on-partial-least-squares-and-principal-component-regression" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38073.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">277</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">30</span> The Influence of Ligands Molecular Structure on the Antibacterial Activity of Some Metal Complexes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac-Kuzmanovi%C4%87">Sanja O. Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87"> Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87"> Strahinja Z. Kovačević</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In last decade, metal-organic complexes have captured intensive attention because of their wide range of biological activities such as antibacterial, antifungal, anticancerous, antimicrobial and antiHIV. Therefore, it is of great importance for the development of coordination chemistry to explore the assembly of functional organic ligands with metal ion and to investigate the relationship between the structure and property. In view of our studies, we reasoned that benzimidazoles complexed to metal ions could act as a potent antibacterial agents. Thus, we have bioassayed the inhibitory potency of benzimidazoles and their metal salts (Co or Ni) against Gram negative bacteria Escherichia coli. In order to validate our in vitro study, we performed in silico studies using molecular docking software’s. The investigated compounds and their metal complexes (Co, Ni) showed good antibacterial activity against Escherichia coli. In silico docking studies of the synthesized compounds suggested that complexed benzimidazoles have a greater binding affinity and enhanced antibacterial activity in comparison with noncomplexed ligands. In view of their enhanced inhibitory properties we propose that the studied complexes can be used as potential pharmaceuticals. This study is financially supported by COST action CM1306 and the project No. 114-451-347/2015-02, financially supported by the Provincial Secretariat for Science and Technological Development of Vojvodina. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=benzimidazoles" title="benzimidazoles">benzimidazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=complexes" title=" complexes"> complexes</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title=" antibacterial"> antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=Escherichia%20coli" title=" Escherichia coli"> Escherichia coli</a>, <a href="https://publications.waset.org/abstracts/search?q=metal" title=" metal"> metal</a> </p> <a href="https://publications.waset.org/abstracts/45084/the-influence-of-ligands-molecular-structure-on-the-antibacterial-activity-of-some-metal-complexes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45084.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">317</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">29</span> Antibacterial Evaluation, in Silico ADME and QSAR Studies of Some Benzimidazole Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87">Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Milo%C5%A1%20Kuzmanovi%C4%87"> Miloš Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovi%C4%87"> Sanja Podunavac-Kuzmanović </a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, various derivatives of benzimidazole have been evaluated against Gram-negative bacteria Escherichia coli. For all investigated compounds the minimum inhibitory concentration (MIC) was determined. Quantitative structure-activity relationships (QSAR) attempts to find consistent relationships between the variations in the values of molecular properties and the biological activity for a series of compounds so that these rules can be used to evaluate new chemical entities. The correlation between MIC and some absorption, distribution, metabolism and excretion (ADME) parameters was investigated, and the mathematical models for predicting the antibacterial activity of this class of compounds were developed. The quality of the multiple linear regression (MLR) models was validated by the leave-one-out (LOO) technique, as well as by the calculation of the statistical parameters for the developed models and the results are discussed on the basis of the statistical data. The results of this study indicate that ADME parameters have a significant effect on the antibacterial activity of this class of compounds. Principal component analysis (PCA) and agglomerative hierarchical clustering algorithms (HCA) confirmed that the investigated molecules can be classified into groups on the basis of the ADME parameters: Madin-Darby Canine Kidney cell permeability (MDCK), Plasma protein binding (PPB%), human intestinal absorption (HIA%) and human colon carcinoma cell permeability (Caco-2). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=benzimidazoles" title="benzimidazoles">benzimidazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a>, <a href="https://publications.waset.org/abstracts/search?q=ADME" title=" ADME"> ADME</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20silico" title=" in silico"> in silico</a> </p> <a href="https://publications.waset.org/abstracts/18974/antibacterial-evaluation-in-silico-adme-and-qsar-studies-of-some-benzimidazole-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18974.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">28</span> Quantitative Structure-Property Relationship Study of Base Dissociation Constants of Some Benzimidazoles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanja%20O.%20Podunavac-Kuzmanovi%C4%87">Sanja O. Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20R.%20Jevri%C4%87"> Lidija R. Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Z.%20Kova%C4%8Devi%C4%87"> Strahinja Z. Kovačević</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Benzimidazoles are a group of compounds with significant antibacterial, antifungal and anticancer activity. The studied compounds consist of the main benzimidazole structure with different combinations of substituens. This study is based on the two-dimensional and three-dimensional molecular modeling and calculation of molecular descriptors (physicochemical and lipophilicity descriptors) of structurally diverse benzimidazoles. Molecular modeling was carried out by using ChemBio3D Ultra version 14.0 software. The obtained 3D models were subjected to energy minimization using molecular mechanics force field method (MM2). The cutoff for structure optimization was set at a gradient of 0.1 kcal/Åmol. The obtained set of molecular descriptors was used in principal component analysis (PCA) of possible similarities and dissimilarities among the studied derivatives. After the molecular modeling, the quantitative structure-property relationship (QSPR) analysis was applied in order to get the mathematical models which can be used in prediction of pKb values of structurally similar benzimidazoles. The obtained models are based on statistically valid multiple linear regression (MLR) equations. The calculated cross-validation parameters indicate the high prediction ability of the established QSPR models. This study is financially supported by COST action CM1306 and the project No. 114-451-347/2015-02, financially supported by the Provincial Secretariat for Science and Technological Development of Vojvodina. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=benzimidazoles" title="benzimidazoles">benzimidazoles</a>, <a href="https://publications.waset.org/abstracts/search?q=chemometrics" title=" chemometrics"> chemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20modeling" title=" molecular modeling"> molecular modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20descriptors" title=" molecular descriptors"> molecular descriptors</a>, <a href="https://publications.waset.org/abstracts/search?q=QSPR" title=" QSPR"> QSPR</a> </p> <a href="https://publications.waset.org/abstracts/45055/quantitative-structure-property-relationship-study-of-base-dissociation-constants-of-some-benzimidazoles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45055.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">289</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Quantitative Structure-Activity Relationship Analysis of Binding Affinity of a Series of Anti-Prion Compounds to Human Prion Protein</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Strahinja%20Kova%C4%8Devi%C4%87">Strahinja Kovačević</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanja%20Podunavac-Kuzmanovi%C4%87"> Sanja Podunavac-Kuzmanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Lidija%20Jevri%C4%87"> Lidija Jevrić</a>, <a href="https://publications.waset.org/abstracts/search?q=Milica%20Karad%C5%BEi%C4%87"> Milica Karadžić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study is based on the quantitative structure-activity relationship (QSAR) analysis of eighteen compounds with anti-prion activity. The structures and anti-prion activities (expressed in response units, RU%) of the analyzed compounds are taken from CHEMBL database. In the first step of analysis 85 molecular descriptors were calculated and based on them the hierarchical cluster analysis (HCA) and principal component analysis (PCA) were carried out in order to detect potential significant similarities or dissimilarities among the studied compounds. The calculated molecular descriptors were physicochemical, lipophilicity and ADMET (absorption, distribution, metabolism, excretion and toxicity) descriptors. The first stage of the QSAR analysis was simple linear regression modeling. It resulted in one acceptable model that correlates Henry's law constant with RU% units. The obtained 2D-QSAR model was validated by cross-validation as an internal validation method. The validation procedure confirmed the model’s quality and therefore it can be used for prediction of anti-prion activity. The next stage of the analysis of anti-prion activity will include 3D-QSAR and molecular docking approaches in order to select the most promising compounds in treatment of prion diseases. These results are the part of the project No. 114-451-268/2016-02 financially supported by the Provincial Secretariat for Science and Technological Development of AP Vojvodina. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anti-prion%20activity" title="anti-prion activity">anti-prion activity</a>, <a href="https://publications.waset.org/abstracts/search?q=chemometrics" title=" chemometrics"> chemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20modeling" title=" molecular modeling"> molecular modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a> </p> <a href="https://publications.waset.org/abstracts/60009/quantitative-structure-activity-relationship-analysis-of-binding-affinity-of-a-series-of-anti-prion-compounds-to-human-prion-protein" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60009.pdf" 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