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Lack of canine COVID-19 data fuels persisting concerns over dog-human interactions - Purdue University News
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<div class="container"> <p style="padding-top:.5em;">March 20, 2023</p> <h1>Lack of canine COVID-19 data fuels persisting concerns over dog-human interactions</h1> <div class="row"> <div class="maincontent col-sm-8 col-xs-12"> <div class="flex-container no-pad--xs"> <div class="flex-item" id="article-photo"> <div class="inner-content"> <img alt="dogs-covid" class="banner" src="https://web.archive.org/web/20230321003009im_/https://www.purdue.edu/uns/images/2023/dogs-covidLO.jpg"/> </div> </div> <!-- end article photo--> <div class="flex-item" id="sidebar"> <div class="inner-content"> <p>A research literature review by Purdue University researchers published in the journal Animals highlights unanswered questions about the COVID-19 virus dynamics between dogs and humans. (Purdue Agricultural Communications photo/Tom Campbell) </p> <div align="center" class="buttons"> <a href="https://web.archive.org/web/20230321003009/https://www.purdue.edu/uns/images/2023/dogs-covidLO.jpg" target="_blank"> <button class="btn btn--photo" type="button"> Download Image </button></a> </div> </div> </div> </div> <!-- end flex-container --> <div> <p>WEST LAFAYETTE, Ind. — Early COVID-19 pandemic suspicions about dogs’ resistance to the disease have given way to a long-haul clinical data gap as new variants of the virus have emerged.</p> <p>“It is not confirmed that the virus can be transmitted from one dog to another dog or from dogs to humans,” said veterinarian Mohamed Kamel, a postdoctoral fellow at <a href="https://web.archive.org/web/20230321003009/http://purdue.edu/" rel="noopener" target="_blank">Purdue University</a>.</p> <p>During the pandemic’s early days, dogs seemed resistant to the coronavirus, showing little evidence of infection or transmission, said <a href="https://web.archive.org/web/20230321003009/https://engineering.purdue.edu/ABE/people/ptProfile?resource_id=172745" rel="noopener" target="_blank">Mohit Verma</a>, assistant professor of <a href="https://web.archive.org/web/20230321003009/https://engineering.purdue.edu/ABE" rel="noopener" target="_blank">agricultural and biological engineering</a> and Purdue’s <a href="https://web.archive.org/web/20230321003009/https://engineering.purdue.edu/BME" rel="noopener" target="_blank">Weldon School of Biomedical Engineering</a>. “As the virus evolved, or maybe the surveillance technology advanced, there seem to be more instances of potentially asymptomatic dogs.”</p> <p>These are among the findings that Kamel, Verma and two co-authors summarized in <a href="https://web.archive.org/web/20230321003009/https://www.mdpi.com/2076-2615/13/3/524" rel="noopener" target="_blank">a research literature review</a> “Interactions Between Humans and Dogs in the COVID-19 Pandemic.” The summary, with recent updates and future perspectives, recently appeared in a special issue of the journal <a href="https://web.archive.org/web/20230321003009/https://www.mdpi.com/journal/animals" rel="noopener" target="_blank">Animals</a> on <a href="https://web.archive.org/web/20230321003009/https://www.mdpi.com/journal/animals/special_issues/Animals_SARS-CoV-2" rel="noopener" target="_blank">Susceptibility of Animals to SARS-CoV-2</a><span>.</span></p> <p>Additional co-authors are Rachel Munds, a research scientist at <a href="https://web.archive.org/web/20230321003009/https://krishidiagnostics.com/" rel="noopener" target="_blank">Krishi Inc.</a> and a Purdue visiting scholar in the Department of Agricultural and Biological Engineering, and Amr El-Sayed of Egypt’s Cairo University.</p> <p><span>Last June the </span><a href="https://web.archive.org/web/20230321003009/http://usda.gov/" rel="noopener" target="_blank">U.S. Department of Agriculture</a><span>’s </span><a href="https://web.archive.org/web/20230321003009/https://www.aphis.usda.gov/aphis/home/" rel="noopener" target="_blank">Animal and Plant Health Inspection Service</a> <span>announced it was committing up to $24 million for research related to SARS-CoV-2. The funding, provided by the </span><a href="https://web.archive.org/web/20230321003009/https://www.usda.gov/arp" rel="noopener" target="_blank">American Rescue Plan Act</a><span>, focuses on the </span><a href="https://web.archive.org/web/20230321003009/https://www.aphis.usda.gov/aphis/ourfocus/onehealth/one-health-sarscov2-in-animals" rel="noopener" target="_blank">One Health concept</a><span>, which recognizes the link between the health of people, animals and the environment.</span></p> <p><span>The SARS-CoV-2 virus that originated in Wuhan, China, in 2019 has infected more than 600 million people globally and had claimed more than 6.5 million lives by October 2022.</span></p> <p><span>“COVID-19 has become one of the most important economic, health and humanitarian problems of the 21st century,” the co-authors wrote in the Animals article. Studies have documented the movement of the SARS-CoV-2 virus through various animal species. And about 75 percent of infectious diseases in humans start in animals.</span></p> <p><span>“This spread raises concerns about the possibility of pet animals serving as reservoirs for the virus,” the co-authors wrote. </span></p> <p>More than two dozen animal species have been infected by SARS-CoV-2 virus, ranging from cats, dogs and rabbits to deer, cattle and gorillas. <span>More than 470 million dogs were owned worldwide before the COVID-19 outbreak. Their </span>susceptibility to the virus remains poorly understood because they are infrequently tested, said Kamel, who is also a faculty member at Cairo University.</p> <p>“Compared to cats or other animals, the susceptibility is less,” Kamel said. He cautioned, however, that the susceptibility of dogs to the new variants may have changed to a lesser or greater extent.</p> <p>“There are a lot of variants. It’s not only one virus,” Kamel said. “The infections differ from the old variant to the new variant.”</p> <p>Dogs’ apparent resistance to COVID-19 could result from their general low levels of the angiotensin converting enzyme (ACE2), target receptors in their lung cells and related mutations.</p> <p>“ACE2 is the main part of the virus attachment found on the cells,” Kamel noted.</p> <p>The Animals journal article also discusses how the spread of an epidemic can be tracked, predicted and contained through a combination of geographic information systems, molecular biology and even detection dogs. Because of their heightened sense of smell, dogs can be trained to detect a wide range of human diseases, Kamel said. Using dogs to detect COVID-19, as reported in the journal article, is fast and less expensive compared to other methods where screening large crowds may be needed.</p> <p>Verma’s startup, Krishi Inc.<span>, is already developing innovative paper-based, rapid-result tests for </span><a href="https://web.archive.org/web/20230321003009/https://link.springer.com/article/10.1186/s13567-021-00997-9" rel="noopener" target="_blank">bovine respiratory disease</a><span>, </span><span>antimicrobial resistance </span>and <a href="https://web.archive.org/web/20230321003009/https://www.sciencedirect.com/science/article/pii/S2590137021000121" rel="noopener" target="_blank">COVID-19</a>. The testing system uses a method called loop-mediated isothermal amplification (LAMP) and is under development in Verma’s lab for <a href="https://web.archive.org/web/20230321003009/https://ag.purdue.edu/news/2023/01/innovative-risk-assessment-tool-for-produce-industry-continues-advancing.html" rel="noopener" target="_blank">produce safety applications</a>. Adapting LAMP for animal testing of SARS-CoV-2 may come next.</p> <p>Krishi Inc. received an initial investment from Ag-Celerator. Created in 2015, Ag-Celerator is a $2 million innovation fund designed to provide critical startup support for Purdue innovators who bring Purdue’s patented intellectual property or “know-how” technologies to market. The fund is operated by <a href="https://web.archive.org/web/20230321003009/https://purduefoundry.com/ventures/overview/">Purdue Ventures</a> with assistance from the <a href="https://web.archive.org/web/20230321003009/https://ag.purdue.edu/" rel="noopener" target="_blank">Purdue University College of Agriculture</a>, the <a href="https://web.archive.org/web/20230321003009/https://otc.prf.org/" rel="noopener" target="_blank">Purdue Research Foundation Office of Technology Commercialization</a> and the agriculture industry.</p> <p>The Animals journal article cites multiple studies from Purdue and elsewhere validating the usefulness of LAMP testing. Krishi’s focus thus far has been developing a test for antimicrobial resistance in animals, but the LAMP assay has broader potential, Verma said.</p> <p>“If we want to do widespread surveillance, can we make our test versatile for any species? LAMP is portable,” Verma said. “Because it can be done in a simple manner and provide results without a lab setup, we can potentially do this on a wider scale and make it cost-effective.”</p> <p>Currently available commercial at-home coronavirus tests for humans can also be used on dogs and cats. However, these tests may not be sensitive enough to detect the lower viral loads in animals.</p> <p>“They’re not validated for animals, so we don’t know how well they would work. That’s the gap we’re hoping to bridge with the test that we are developing – better tools of surveillance,” Verma said. </p> <p><strong>Writer:</strong> Steve Koppes</p> <p><strong>Media contact:</strong> Maureen Manier, <a href="https://web.archive.org/web/20230321003009/mailto:mmanier@purdue.edu">mmanier@purdue.edu</a></p> <p><strong>Sources:</strong> Mohit Verma, <a href="https://web.archive.org/web/20230321003009/mailto:msverma@purdue.edu">msverma@purdue.edu</a>; Mohamed Kamel, <a href="https://web.archive.org/web/20230321003009/mailto:mkamalka@purdue.edu">mkamalka@purdue.edu</a></p> <p><strong>Agricultural Communications:</strong> 765-494-8415;</p> <p>Maureen Manier, Department Head, <a href="https://web.archive.org/web/20230321003009/mailto:mmanier@purdue.edu" rel="noopener" target="_blank">mmanier@purdue.edu</a></p> <p><a href="https://web.archive.org/web/20230321003009/https://ag.purdue.edu/agcomm/pages/news.aspx" rel="noopener" target="_blank">Agriculture News Page</a></p> 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