Adaptive Clinical Trial Design with nQuery

<!doctype html><html lang="en-us"><head> <meta charset="utf-8"> <title>Adaptive Clinical Trial Design with nQuery</title> <link rel="shortcut icon" href="https://www.statsols.com/hubfs/nQuery%20clinical%20trial%20design%20software%20icon.png"> <meta name="description" content="From group sequential designs to sample size re-estimation, design and analyze a wide range of adaptive designs with nQuery"> <meta name="viewport" content="width=device-width, initial-scale=1"> <script src="/hs/hsstatic/jquery-libs/static-1.4/jquery/jquery-1.11.2.js"></script> <script>hsjQuery = window['jQuery'];</script> <meta property="og:description" content="From group sequential designs to sample size re-estimation, design and analyze a wide range of adaptive designs with nQuery"> <meta property="og:title" content="Adaptive Clinical Trial Design with nQuery"> <meta name="twitter:description" content="From group sequential designs to sample size re-estimation, design and analyze a wide range of adaptive designs with nQuery"> <meta name="twitter:title" content="Adaptive Clinical Trial Design with nQuery"> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://www.statsols.com/hs-fs/hub/488764/hub_generated/template_assets/130521435988/1729287983428/nquery-theme/cli-build/css/styles.min.css"> <link rel="stylesheet" href="https://www.statsols.com/hs-fs/hub/488764/hub_generated/template_assets/130515235912/1723206765330/nquery-theme/css/main.min.css"> <link rel="stylesheet" href="https://www.statsols.com/hs-fs/hub/488764/hub_generated/template_assets/130515336359/1725989622564/nquery-theme/css/theme-overrides.min.css"> <link rel="stylesheet" href="https://www.statsols.com/hs-fs/hub/488764/hub_generated/module_assets/131433263946/1726837309233/module_131433263946_floating-texture.min.css"> <style> #hs_cos_wrapper_module_170500823504218 .button-wrapper { text-align:LEFT; } #hs_cos_wrapper_module_170500823504218 .button { border:2px solid #2ec99b; } #hs_cos_wrapper_module_170500823504218 .button:hover, #hs_cos_wrapper_module_170500823504218 .button:focus {} #hs_cos_wrapper_module_170500823504218 .button:active {} </style> <link rel="stylesheet" href="https://cdn2.hubspot.net/hub/-1/hub_generated/module_assets/-35056501883/1731934115154/module_-35056501883_Video.min.css"> <style> #oembed_container-widget_1706199325587 .oembed_custom-thumbnail_icon svg { fill: #ffffff; } </style> <style> .shadow-img img { border-radius: 8px; border: 1px solid #D9D9D9 !important; box-shadow: 4px 4px 8px 0px rgba(0, 0, 0, 0.15), 0px 0px 16px 0px rgba(0, 0, 0, 0.05); } </style> <style> #hs_cos_wrapper_module_17050080836147 .button-wrapper { text-align:CENTER; } #hs_cos_wrapper_module_17050080836147 .button {} #hs_cos_wrapper_module_17050080836147 .button:hover, #hs_cos_wrapper_module_17050080836147 .button:focus {} #hs_cos_wrapper_module_17050080836147 .button:active {} </style> <style> #oembed_container-module_170500831361813 .oembed_custom-thumbnail_icon svg { fill: #ffffff; } </style> <style> #hs_cos_wrapper_module_17050083256844 .button-wrapper { text-align:CENTER; } #hs_cos_wrapper_module_17050083256844 .button {} #hs_cos_wrapper_module_17050083256844 .button:hover, #hs_cos_wrapper_module_17050083256844 .button:focus {} #hs_cos_wrapper_module_17050083256844 .button:active {} </style> <link rel="stylesheet" href="https://www.statsols.com/hs-fs/hub/488764/hub_generated/module_assets/130951228707/1692540902652/module_130951228707_faq.min.css"> <link rel="stylesheet" href="https://www.statsols.com/hs-fs/hub/488764/hub_generated/module_assets/130696072812/1726837309422/module_130696072812_custom-card.min.css"> <style> #hs_cos_wrapper_module_170500841085417 .button-wrapper { text-align:CENTER; } #hs_cos_wrapper_module_170500841085417 .button { margin-top:24px; } #hs_cos_wrapper_module_170500841085417 .button:hover, #hs_cos_wrapper_module_170500841085417 .button:focus {} #hs_cos_wrapper_module_170500841085417 .button:active {} </style> <style> #hs_cos_wrapper_module_170500841085419 .button-wrapper { text-align:CENTER; } #hs_cos_wrapper_module_170500841085419 .button { background-color:rgba(0,0,0,0.0); border:2px solid #2ec99b; margin-top:24px; } #hs_cos_wrapper_module_170500841085419 .button:hover, #hs_cos_wrapper_module_170500841085419 .button:focus { background-color:rgba(0,0,0,0.0); } #hs_cos_wrapper_module_170500841085419 .button:active { background-color:rgba(80,80,80,0.0); } </style> <style> #hs_cos_wrapper_module_170500841085423 .button-wrapper { text-align:RIGHT; } #hs_cos_wrapper_module_170500841085423 .button { margin-top:24px; } #hs_cos_wrapper_module_170500841085423 .button:hover, #hs_cos_wrapper_module_170500841085423 .button:focus {} #hs_cos_wrapper_module_170500841085423 .button:active {} </style> <style> #hs_cos_wrapper_module_170500841085425 .button-wrapper { text-align:LEFT; } #hs_cos_wrapper_module_170500841085425 .button { background-color:rgba(0,0,0,0.0); border:2px solid #2ec99b; margin-top:24px; } #hs_cos_wrapper_module_170500841085425 .button:hover, #hs_cos_wrapper_module_170500841085425 .button:focus { background-color:rgba(0,0,0,0.0); } #hs_cos_wrapper_module_170500841085425 .button:active { background-color:rgba(80,80,80,0.0); } </style> <style> @font-face { font-family: "Public Sans"; font-weight: 500; font-style: normal; font-display: swap; src: url("/_hcms/googlefonts/Public_Sans/500.woff2") format("woff2"), url("/_hcms/googlefonts/Public_Sans/500.woff") format("woff"); } @font-face { font-family: "Public Sans"; font-weight: 400; font-style: normal; font-display: swap; src: url("/_hcms/googlefonts/Public_Sans/regular.woff2") format("woff2"), url("/_hcms/googlefonts/Public_Sans/regular.woff") format("woff"); } @font-face { font-family: "Public Sans"; font-weight: 300; font-style: normal; font-display: swap; src: url("/_hcms/googlefonts/Public_Sans/300.woff2") format("woff2"), url("/_hcms/googlefonts/Public_Sans/300.woff") format("woff"); } </style>  <style id="hs_editor_style" type="text/css"> #hs_cos_wrapper_module_170500823504215 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500823504216 { display: block !important; padding-bottom: 40px !important } #hs_cos_wrapper_module_170500827922713 { display: block !important; margin-bottom: 0px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500827922714 { display: block !important; margin-bottom: 36px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500828631415 { display: block !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500828631416 { display: block !important; margin-bottom: 36px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500829236413 { display: block !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500829236414 { display: block !important; margin-bottom: 36px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500813490115 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500813490119 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500813490123 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500814000815 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500814000819 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500814000823 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500831361810 { display: block !important; margin-bottom: 32px !important } #hs_cos_wrapper_module_170500823504215 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500823504216 { display: block !important; padding-bottom: 40px !important } #hs_cos_wrapper_module_170500827922713 { display: block !important; margin-bottom: 0px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500827922714 { display: block !important; margin-bottom: 36px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500828631415 { display: block !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500828631416 { display: block !important; margin-bottom: 36px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500829236413 { display: block !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500829236414 { display: block !important; margin-bottom: 36px !important; margin-top: 12px !important } #hs_cos_wrapper_module_170500813490123 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500813490119 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500813490115 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500814000823 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500814000819 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500814000815 { display: block !important; margin-bottom: 20px !important } #hs_cos_wrapper_module_170500831361810 { display: block !important; margin-bottom: 32px !important } .dnd_area-row-2-max-width-section-centering > .row-fluid { max-width: 1140px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-3-max-width-section-centering > .row-fluid { max-width: 1140px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-4-max-width-section-centering > .row-fluid { max-width: 1140px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-6-max-width-section-centering > .row-fluid { max-width: 900px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-7-max-width-section-centering > .row-fluid { max-width: 1200px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-8-max-width-section-centering > .row-fluid { max-width: 1200px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-12-max-width-section-centering > .row-fluid { max-width: 750px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-14-max-width-section-centering > .row-fluid { max-width: 750px !important; margin-left: auto !important; margin-right: auto !important; } .module_170500813490123-flexbox-positioning { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-align: start !important; -ms-flex-pack: start; display: flex !important; flex-direction: column !important; align-items: flex-start !important; justify-content: flex-start; } .module_170500813490123-flexbox-positioning > div { max-width: 100%; flex-shrink: 0 !important; } .module_170500813490119-flexbox-positioning { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-align: start !important; -ms-flex-pack: start; display: flex !important; flex-direction: column !important; align-items: flex-start !important; justify-content: flex-start; } .module_170500813490119-flexbox-positioning > div { max-width: 100%; flex-shrink: 0 !important; } .module_170500813490115-flexbox-positioning { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-align: start !important; -ms-flex-pack: start; display: flex !important; flex-direction: column !important; align-items: flex-start !important; justify-content: flex-start; } .module_170500813490115-flexbox-positioning > div { max-width: 100%; flex-shrink: 0 !important; } .module_170500814000823-flexbox-positioning { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-align: start !important; -ms-flex-pack: start; display: flex !important; flex-direction: column !important; align-items: flex-start !important; justify-content: flex-start; } .module_170500814000823-flexbox-positioning > div { max-width: 100%; flex-shrink: 0 !important; } .module_170500814000819-flexbox-positioning { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-align: start !important; -ms-flex-pack: start; display: flex !important; flex-direction: column !important; align-items: flex-start !important; justify-content: flex-start; } .module_170500814000819-flexbox-positioning > div { max-width: 100%; flex-shrink: 0 !important; } .module_170500814000815-flexbox-positioning { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-align: start !important; -ms-flex-pack: start; display: flex !important; flex-direction: column !important; align-items: flex-start !important; justify-content: flex-start; } .module_170500814000815-flexbox-positioning > div { max-width: 100%; flex-shrink: 0 !important; } /* HubSpot Non-stacked Media Query Styles */ @media (min-width:768px) { .dnd_area-row-0-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .dnd_area-row-2-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .dnd_area-row-3-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .dnd_area-row-4-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .cell_170500823504210-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_170500823504210-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050082350429-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_17050082350429-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050082792279-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_17050082792279-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050082792278-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_17050082792278-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050082863149-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_17050082863149-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050082863148-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_17050082863148-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050082923649-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_17050082923649-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050082923648-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_17050082923648-vertical-alignment > div { flex-shrink: 0 !important; } .cell_17050084108549-row-1-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .cell_17050084108549-row-2-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .cell_170500841085415-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_170500841085415-vertical-alignment > div { flex-shrink: 0 !important; } .cell_170500841085415-row-0-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .module_170500841085419-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .module_170500841085419-vertical-alignment > div { flex-shrink: 0 !important; } .cell_170500841085414-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_170500841085414-vertical-alignment > div { flex-shrink: 0 !important; } .cell_170500841085414-row-0-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .module_170500841085417-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .module_170500841085417-vertical-alignment > div { flex-shrink: 0 !important; } .cell_170500841085421-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_170500841085421-vertical-alignment > div { flex-shrink: 0 !important; } .cell_170500841085421-row-0-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .module_170500841085425-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .module_170500841085425-vertical-alignment > div { flex-shrink: 0 !important; } .cell_170500841085420-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_170500841085420-vertical-alignment > div { flex-shrink: 0 !important; } .cell_170500841085420-row-0-vertical-alignment > .row-fluid { display: -ms-flexbox !important; -ms-flex-direction: row; display: flex !important; flex-direction: row; } .module_170500841085423-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .module_170500841085423-vertical-alignment > div { flex-shrink: 0 !important; } } /* HubSpot Styles (default) */ .dnd_area-row-0-background-layers { background-image: linear-gradient(rgba(21, 36, 48, 1), rgba(21, 36, 48, 1)) !important; background-position: left top !important; background-size: auto !important; background-repeat: no-repeat !important; } .dnd_area-row-1-padding { padding-top: 80px !important; padding-bottom: 32px !important; } .dnd_area-row-2-padding { padding-top: 40px !important; padding-bottom: 40px !important; } .dnd_area-row-3-padding { padding-top: 40px !important; padding-bottom: 40px !important; } .dnd_area-row-4-padding { padding-top: 40px !important; padding-bottom: 40px !important; } .dnd_area-row-5-padding { padding-top: 40px !important; padding-bottom: 120px !important; } .dnd_area-row-6-padding { padding-top: 120px !important; padding-bottom: 40px !important; } .dnd_area-row-6-background-layers { background-image: linear-gradient(rgba(243, 243, 239, 1), rgba(243, 243, 239, 1)) !important; background-position: left top !important; background-size: auto !important; background-repeat: no-repeat !important; } .dnd_area-row-7-padding { padding-top: 0px !important; padding-bottom: 32px !important; } .dnd_area-row-7-background-layers { background-image: linear-gradient(rgba(243, 243, 239, 1), rgba(243, 243, 239, 1)) !important; background-position: left top !important; background-size: auto !important; background-repeat: no-repeat !important; } .dnd_area-row-8-padding { padding-top: 0px !important; padding-bottom: 120px !important; } .dnd_area-row-8-background-layers { background-image: linear-gradient(rgba(243, 243, 239, 1), rgba(243, 243, 239, 1)) !important; background-position: left top !important; background-size: auto !important; background-repeat: no-repeat !important; } .dnd_area-row-9-padding { padding-top: 120px !important; padding-bottom: 40px !important; } .dnd_area-row-10-padding { padding-top: 64px !important; padding-bottom: 0px !important; } .dnd_area-row-11-padding { padding-top: 120px !important; padding-bottom: 40px !important; } .dnd_area-row-12-padding { padding-top: 0px !important; padding-bottom: 0px !important; } .dnd_area-row-13-padding { padding-top: 80px !important; padding-bottom: 40px !important; } .dnd_area-row-14-padding { padding-top: 0px !important; padding-bottom: 0px !important; } .dnd_area-row-15-padding { padding-bottom: 48px !important; } .dnd_area-row-15-background-layers { background-image: linear-gradient(rgba(255, 255, 255, 1), rgba(255, 255, 255, 1)) !important; background-position: left top !important; background-size: auto !important; background-repeat: no-repeat !important; } .dnd_area-row-16-padding { padding-top: 0px !important; } .dnd_area-row-16-background-layers { background-image: linear-gradient(rgba(255, 255, 255, 1), rgba(255, 255, 255, 1)) !important; background-position: left top !important; background-size: auto !important; background-repeat: no-repeat !important; } .dnd_area-row-17-padding { padding-top: 80px !important; padding-bottom: 80px !important; } .dnd_area-row-17-background-layers { background-image: linear-gradient(rgba(243, 243, 239, 1), rgba(243, 243, 239, 1)) !important; background-position: left top !important; background-size: auto !important; background-repeat: no-repeat !important; } .cell_170500823504210-padding { padding-left: 0px !important; padding-right: 0px !important; } .cell_17050080620965-padding { padding-left: 0px !important; padding-right: 0px !important; } .cell_17050080620964-padding { padding-left: 0px !important; padding-right: 0px !important; } .cell_17050080620963-padding { padding-left: 0px !important; padding-right: 0px !important; } .cell_17050084108549-row-1-hidden { display: none !important; } .cell_170500841085421-padding { padding-left: 0px !important; } .cell_170500841085420-padding { padding-right: 0px !important; } /* HubSpot Styles (mobile) */ @media (max-width: 768px) { .dnd_area-row-0-padding { padding-bottom: 60px !important; } .dnd_area-row-1-padding { padding-top: 60px !important; padding-bottom: 0px !important; } .dnd_area-row-5-padding { padding-top: 0px !important; padding-bottom: 60px !important; } .dnd_area-row-6-padding { padding-top: 60px !important; } .dnd_area-row-8-padding { padding-bottom: 60px !important; } .dnd_area-row-9-padding { padding-top: 60px !important; } .dnd_area-row-10-padding { padding-top: 0px !important; padding-bottom: 60px !important; } .dnd_area-row-11-padding { padding-top: 60px !important; } .dnd_area-row-15-padding { padding-top: 40px !important; } .dnd_area-row-17-padding { padding-top: 60px !important; padding-bottom: 60px !important; } .cell_17050082350429-margin { margin-bottom: 40px !important; } .cell_17050082863148-margin { margin-bottom: 20px !important; } .cell_17050082923648-margin { margin-bottom: 20px !important; } .cell_170500813490111-padding { padding-bottom: 40px !important; } .cell_170500813490110-margin { margin-bottom: 40px !important; } .cell_170500814000811-padding { padding-bottom: 40px !important; } .cell_170500814000810-margin { margin-bottom: 40px !important; } .cell_17050080620964-padding { padding-bottom: 40px !important; } .cell_17050080620963-margin { margin-bottom: 40px !important; } .cell_17050084108549-row-1-hidden { display: block !important; } .cell_17050084108549-row-2-hidden { display: none !important; } .cell_170500841085421-row-0-hidden { display: block !important; } } </style>  <script> var _hsp = window._hsp = window._hsp || []; _hsp.push(['addPrivacyConsentListener', function(consent) { if (consent.allowed || (consent.categories && consent.categories.analytics)) { (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','ga'); ga('create','UA-48886675-1','auto'); ga('send','pageview'); }}]); </script>   <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; if (!window._hsGoogleConsentRunOnce) { window._hsGoogleConsentRunOnce = true; gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); if (useGoogleConsentModeV2) { _hsp.push(['useGoogleConsentModeV2']) } else { _hsp.push(['addPrivacyConsentListener', function(consent){ var hasAnalyticsConsent = consent && (consent.allowed || (consent.categories && consent.categories.analytics)); var hasAdsConsent = consent && (consent.allowed || (consent.categories && consent.categories.advertisement)); gtag('consent', 'update', { 'ad_storage': hasAdsConsent ? 'granted' : 'denied', 'analytics_storage': hasAnalyticsConsent ? 'granted' : 'denied', 'ad_user_data': hasAdsConsent ? 'granted' : 'denied', 'ad_personalization': hasAdsConsent ? 'granted' : 'denied' }); }]); } } gtag('js', new Date()); gtag('set', 'developer_id.dZTQ1Zm', true); gtag('config', 'G-CZWZBFX5J3'); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-CZWZBFX5J3"></script>   <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; var hsLoadGtm = function loadGtm() { if(window._hsGtmLoadOnce) { return; } if (useGoogleConsentModeV2) { gtag('set','developer_id.dZTQ1Zm',true); gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); _hsp.push(['useGoogleConsentModeV2']) } (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MW5Q269'); window._hsGtmLoadOnce = true; }; _hsp.push(['addPrivacyConsentListener', function(consent){ if(consent.allowed || (consent.categories && consent.categories.analytics)){ hsLoadGtm(); } }]); </script>  <link rel="canonical" href="https://www.statsols.com/nquery/adapt">  <script type="text/javascript"> window._vwo_code = window._vwo_code || (function(){ var account_id=581338, settings_tolerance=2000, library_tolerance=2500, use_existing_jquery=false, is_spa=1, hide_element='body', /* DO NOT EDIT BELOW THIS LINE */ f=false,d=document,code={use_existing_jquery:function(){return use_existing_jquery;},library_tolerance:function(){return library_tolerance;},finish:function(){if(!f){f=true;var a=d.getElementById('_vis_opt_path_hides');if(a)a.parentNode.removeChild(a);}},finished:function(){return f;},load:function(a){var b=d.createElement('script');b.src=a;b.type='text/javascript';b.innerText;b.onerror=function(){_vwo_code.finish();};d.getElementsByTagName('head')[0].appendChild(b);},init:function(){ window.settings_timer=setTimeout(function () {_vwo_code.finish() },settings_tolerance);var a=d.createElement('style'),b=hide_element?hide_element+'{opacity:0 !important;filter:alpha(opacity=0) !important;background:none !important;}':'',h=d.getElementsByTagName('head')[0];a.setAttribute('id','_vis_opt_path_hides');a.setAttribute('type','text/css');if(a.styleSheet)a.styleSheet.cssText=b;else a.appendChild(d.createTextNode(b));h.appendChild(a);this.load('https://dev.visualwebsiteoptimizer.com/j.php?a='+account_id+'&u='+encodeURIComponent(d.URL)+'&f='+(+is_spa)+'&r='+Math.random());return settings_timer; }};window._vwo_settings_timer = code.init(); return code; }()); </script>  <script id="Cookiebot" src="https://consent.cookiebot.com/uc.js" data-cbid="f03b883a-7303-42df-be4e-801da49824e4" data-blockingmode="auto" type="text/javascript"></script> <script data-cookieconsent="ignore"> window.dataLayer = window.dataLayer || []; function gtag() { dataLayer.push(arguments); } gtag("consent", "default", { ad_storage: "denied", analytics_storage: "denied", wait_for_update: 500 }); gtag("set", "ads_data_redaction", true); </script> <script src="https://d64a6295fb0c4c7cb2994fc6daf96e1f.js.ubembed.com" async></script>  <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MW5Q269');</script>   <script type="text/javascript"> (function(c,l,a,r,i,t,y){ c[a]=c[a]||function(){(c[a].q=c[a].q||[]).push(arguments)}; t=l.createElement(r);t.async=1;t.src="https://www.clarity.ms/tag/"+i; y=l.getElementsByTagName(r)[0];y.parentNode.insertBefore(t,y); })(window, document, "clarity", "script", "mnmqbubcow"); </script> <meta property="og:image" content="https://www.statsols.com/hubfs/nQuery%20-%20The%20complete%20trial%20design%20platform.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="630"> <meta property="og:image:alt" content="From group sequential designs to sample size re-estimation, design and analyze a wide range of adaptive designs with nQuery"> <meta name="twitter:image" content="https://www.statsols.com/hubfs/nQuery%20-%20The%20complete%20trial%20design%20platform.png"> <meta name="twitter:image:alt" content="From group sequential designs to sample size re-estimation, design and analyze a wide range of adaptive designs with nQuery"> <meta property="og:url" content="https://www.statsols.com/nquery/adapt"> <meta name="twitter:card" content="summary_large_image"> <meta http-equiv="content-language" content="en-us"> <meta name="generator" content="HubSpot"></head> <body>  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MW5Q269" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div class="body-wrapper hs-content-id-6492385781 hs-site-page page hs-content-path-nquery-adapt hs-content-name-nquery-adapt-product-page-benefits "> <div data-global-resource-path="nquery-theme/cli-build/partials/header.html"> <div class="bg-nq-forest hidden lg:block relative"> <div class="container px-6 py-[12px]"> <div class="flex items-center"> <div class="lg:w-[200px]"> <a target="_blank" href="https://www.dotmatics.com/"> <svg width="101" height="16" viewbox="0 0 101 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M14.5625 10.232C14.5625 7.00104 17.136 4.44229 20.3886 4.44229C23.6177 4.44229 26.2148 6.99974 26.2148 10.232C26.2148 13.4631 23.6177 15.9984 20.3886 15.9984C17.1373 15.9984 14.5625 13.4631 14.5625 10.232ZM20.3886 13.6871C22.2621 13.6871 23.7527 12.1837 23.7527 10.232C23.7527 8.25696 22.2621 6.7535 20.3886 6.7535C18.4693 6.7535 17.0246 8.25696 17.0246 10.232C17.0246 12.2071 18.4693 13.6871 20.3886 13.6871Z" fill="white" /> <path d="M26.7891 4.73413H28.8893V1.81711H31.396V4.73413H34.3536V6.91116H31.396V11.8476C31.396 12.9693 31.961 13.5308 33.0216 13.5308H34.3536V15.7078H32.7057C30.1767 15.7078 28.8893 14.5405 28.8893 12.0274V6.91116H26.7891V4.73413Z" fill="white" /> <path d="M36.3841 4.73394H39.0717V5.72148C39.975 4.80169 41.1719 4.44211 42.1198 4.44211C43.52 4.44211 44.671 5.09222 45.3711 6.16965C46.2521 5.07007 47.7191 4.44211 49.2543 4.44211C51.761 4.44211 53.3866 6.14751 53.3866 8.86259V15.7063H50.88V9.44626C50.88 7.78516 50.0449 6.75332 48.6224 6.75332C47.3809 6.75332 46.138 7.60537 46.138 9.46841V15.7063H43.6314V9.44626C43.6314 7.76301 42.7504 6.75332 41.2834 6.75332C40.0418 6.75332 38.8895 7.65097 38.8895 9.6482V15.7063H36.3828V4.73394H36.3841Z" fill="white" /> <path d="M55.0117 12.6336C55.0117 10.4801 56.8183 8.97659 60.2046 8.97659H62.1921V8.70691C62.1921 7.33764 61.357 6.48559 59.9346 6.48559C58.7153 6.48559 57.6993 7.24904 57.6088 8.37078H55.1022C55.2149 6.05957 57.2247 4.44406 59.9791 4.44406C62.9145 4.44406 64.7211 6.21721 64.7211 8.9323V15.7083H62.2603V14.5644C61.5379 15.4165 60.3187 16.0001 59.1217 16.0001C56.6374 16.0001 55.0117 14.6765 55.0117 12.6349V12.6336ZM59.3249 14.0472C60.9729 14.0472 62.2603 12.7235 62.2603 10.996V10.8162H60.2728C58.4439 10.8162 57.4725 11.422 57.4725 12.5659C57.4725 13.4414 58.128 14.0472 59.3236 14.0472H59.3249Z" fill="white" /> <path d="M65.8516 4.73413H67.9518V1.81711H70.4585V4.73413H73.4161V6.91116H70.4585V11.8476C70.4585 12.9693 71.0235 13.5308 72.0841 13.5308H73.4161V15.7078H71.7682C69.2392 15.7078 67.9518 14.5405 67.9518 12.0274V6.91116H65.8516V4.73413Z" fill="white" /> <path d="M74.9023 0.0221863H77.5663V2.78157H74.9023V0.0221863ZM77.4995 4.7345V15.7069H74.9928V4.7345H77.4995Z" fill="white" /> <path d="M79.2148 10.2319C79.2148 6.93311 81.7661 4.44211 84.9951 4.44211C87.6591 4.44211 89.9179 6.2374 90.2562 8.66066H87.705C87.4559 7.60667 86.2825 6.77547 84.9505 6.77547C83.0994 6.77547 81.6769 8.23463 81.6769 10.2306C81.6769 12.2056 83.0994 13.6635 84.9505 13.6635C86.2825 13.6635 87.4572 12.8558 87.7272 11.6884H90.2562C89.9625 14.2459 87.6827 15.9969 84.9951 15.9969C81.7661 15.9969 79.2148 13.528 79.2148 10.2306V10.2319Z" fill="white" /> <path d="M91.6328 12.3411H94.0267C94.1172 13.3508 94.9523 14.0465 96.2174 14.0465C97.4589 14.0465 98.1813 13.4407 98.1813 12.633C98.1813 10.2996 91.836 11.9373 91.836 7.8529C91.836 5.78793 93.5744 4.44211 95.9683 4.44211C98.3845 4.44211 100.191 5.60944 100.417 7.80731H97.9558C97.8208 6.97741 97.0302 6.32599 95.946 6.32599C95.0205 6.32599 94.1853 6.72987 94.1853 7.60537C94.1853 9.78239 100.621 8.07699 100.621 12.3398C100.621 14.4934 98.8145 15.9969 96.2174 15.9969C93.6203 15.9969 91.815 14.651 91.6341 12.3398L91.6328 12.3411Z" fill="white" /> <path d="M5.70073 -9.15527e-05H0.507812V2.49221L5.85936 2.48961C8.77242 2.48961 10.8727 4.77867 10.8727 7.78559C10.8727 10.8824 8.75014 13.2158 5.85936 13.2158H3.1495V10.4017H0.507812V15.7068H5.70073C10.2617 15.7068 13.5812 12.3403 13.5812 7.78559C13.5812 3.32081 10.2617 -9.15527e-05 5.70073 -9.15527e-05Z" fill="white" /> <path d="M3.14693 5.12531H0.5V7.75571H3.14693V5.12531Z" fill="white" /> </svg> </a> </div> <div class="flex items-center group cursor-pointer universal-dropdown-trigger" id="universal-dropdown-trigger"> <div> <p class="text-white text-[14px] group-hover:text-nq-jade m-0 select-none font-p"> Explore the Scientific R&D Platform </p> </div> <div class="px-1"> <svg class="text-nq-jade duration-200 transition-transform origin-center rotate-0 universal-dropdown-caret block" width="17" height="16" viewbox="0 0 17 16" fill="none" xmlns="http://www.w3.org/2000/svg" stroke="currentColor"> <path d="M4.62109 6L8.62109 10L12.6211 6" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> </div> </div> <div class="absolute left-0 right-0 bg-nq-forest z-20 hidden border-t border-b-0 border-x-0 border-white/20 border-solid pb-8" id="universal-dropdown"> <div class="absolute right-0 bottom-0 flex justify-end"> <img class="w-1/2" alt="Top Bar background texture" classs="select-none" style="z-index:-1" src="https://flow-cytometry.net/wp-content/uploads/2024/07/nav-bg.png"> </div> <div class="container px-6"> <div class="py-[30px]"> <div class="flex flex-wrap -mx-6"> <div class="lg:w-1/5 px-6"> <img class="mb-3 w-3/4" src="https://flow-cytometry.net/wp-content/uploads/2024/07/Luma-TM.png"> <p class="text-[14px] text-white mb-[32px] font-p font-semibold">Scientific intelligence platform for AI-powered data management and workflow automation </p> <div class="mb-3"> <a target="_blank" href="https://www.dotmatics.com/luma-data-management-platform" class="btn btn-sm border-nq-jade text-white border-solid hover:bg-nq-jade hover:text-white font-bold font-p">Explore Luma   <svg class="inline-block mb-1" stroke="currentColor" fill="currentColor" stroke-width="0" viewbox="0 0 512 512" height="15px" width="15px" xmlns="http://www.w3.org/2000/svg"><path d="M432,320H400a16,16,0,0,0-16,16V448H64V128H208a16,16,0,0,0,16-16V80a16,16,0,0,0-16-16H48A48,48,0,0,0,0,112V464a48,48,0,0,0,48,48H400a48,48,0,0,0,48-48V336A16,16,0,0,0,432,320ZM488,0h-128c-21.37,0-32.05,25.91-17,41l35.73,35.73L135,320.37a24,24,0,0,0,0,34L157.67,377a24,24,0,0,0,34,0L435.28,133.32,471,169c15,15,41,4.5,41-17V24A24,24,0,0,0,488,0Z"></path></svg></a> </div> </div> <div class="lg:w-4/5 px-6"> <div class="grid grid-cols-4 gap-2 mb-6"> <div class=""> <a target="_blank" href="https://www.graphpad.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://flow-cytometry.net/wp-content/uploads/2024/07/Prism-Logo-White-2.png" alt="Prism logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Statistical analysis and graphing software for scientists </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://www.geneious.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://flow-cytometry.net/wp-content/uploads/2024/07/Geneious-Logo-White-2.png" alt="Geneious logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Bioinformatics, cloning, and antibody discovery software </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://www.snapgene.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-SnapGene.svg" alt="SnapGene logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Plan, visualize, & document core molecular biology procedures </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://proteinmetrics.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-Protein-Metrics.svg" alt="Protein Metrics logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Proteomics software for analysis of mass spec data </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://www.labarchives.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://flow-cytometry.net/wp-content/uploads/2024/07/LabArchives-Logo-White-2.png" alt="LabArchives logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Electronic Lab Notebook to organize, search and share data </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://www.omiq.ai/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-OMIQ.svg" alt="OMIQ logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Modern cytometry analysis platform </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://denovosoftware.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-FCS-Express.svg" alt="FCS Express logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Analysis, statistics, graphing and reporting of flow cytometry data </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://flow-cytometry.net/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://flow-cytometry.net/wp-content/uploads/2024/07/EasyPanel-Logo-White-2.png" alt="Easy Panel logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Intelligent panel design & inventory management for flow cytometry </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://www.statsols.com/?hsLang=en-us" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-nQuery.svg" alt="nQuery logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Software to optimize designs of clinical trials </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://www.mstarcfd.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://flow-cytometry.net/wp-content/uploads/2024/07/M-Star-Logo-White-2.png" alt="M-Star logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Computational fluid dynamics (CFD) software for engineers and researchers </p> </div> </a> </div> <div class=""> <a target="_blank" href="https://softgenetics.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar" class="p-[16px] bg-[#1a2836d9] rounded-[6px] block h-full hover:bg-white/10 border border-solid border-[#F3F3EF36] hover:border-nq-jade relative group transition-none"> <div class="mb-3 "> <img class="h-[27px] object-contain inline-block text-left" src="https://flow-cytometry.net/wp-content/uploads/2024/07/SoftGenetics-Logo-White-2.png" alt="SoftGenetics logo"> </div> <div> <p class="text-white m-0 text-[12px] font-p"> Genetic analysis software for research, forensics & healthcare applications </p> </div> </a> </div> </div> <div class="mt-6"> <a target="_blank" href="https://www.dotmatics.com/portfolio" class="btn border-nq-jade text-white border-solid hover:bg-nq-jade hover:text-white font-bold font-p btn-sm">Explore the Scientific Software   <svg class="inline-block mb-1" stroke="currentColor" fill="currentColor" stroke-width="0" viewbox="0 0 512 512" height="15px" width="15px" xmlns="http://www.w3.org/2000/svg"><path d="M432,320H400a16,16,0,0,0-16,16V448H64V128H208a16,16,0,0,0,16-16V80a16,16,0,0,0-16-16H48A48,48,0,0,0,0,112V464a48,48,0,0,0,48,48H400a48,48,0,0,0,48-48V336A16,16,0,0,0,432,320ZM488,0h-128c-21.37,0-32.05,25.91-17,41l35.73,35.73L135,320.37a24,24,0,0,0,0,34L157.67,377a24,24,0,0,0,34,0L435.28,133.32,471,169c15,15,41,4.5,41-17V24A24,24,0,0,0,488,0Z"></path></svg></a> </div> </div> </div> </div> </div> </div> </div> <nav class="bg-white relative z-10 main-nav"> <div class="container px-6"> <div class="flex items-center"> <div class="w-1/2 sm:w-1/3 md:w-1/4 lg:w-1/6"> <div class="w-full py-3 lg:py-0"> <div id="hs_cos_wrapper_header_logo" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-logo" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_header_logo_hs_logo_widget" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_logo" style="" data-hs-cos-general-type="widget" data-hs-cos-type="logo"><a href="https://www.statsols.com/?hsLang=en-us" id="hs-link-header_logo_hs_logo_widget" style="border-width:0px;border:0px;"><img src="https://www.statsols.com/hs-fs/hubfs/nquery-logo-dark.png?width=163&height=175&name=nquery-logo-dark.png" class="hs-image-widget " height="175" style="height: auto;width:163px;border-width:0px;border:0px;" width="163" alt="nQuery Logo" title="nQuery Logo" srcset="https://www.statsols.com/hs-fs/hubfs/nquery-logo-dark.png?width=82&height=88&name=nquery-logo-dark.png 82w, https://www.statsols.com/hs-fs/hubfs/nquery-logo-dark.png?width=163&height=175&name=nquery-logo-dark.png 163w, https://www.statsols.com/hs-fs/hubfs/nquery-logo-dark.png?width=245&height=263&name=nquery-logo-dark.png 245w, https://www.statsols.com/hs-fs/hubfs/nquery-logo-dark.png?width=326&height=350&name=nquery-logo-dark.png 326w, https://www.statsols.com/hs-fs/hubfs/nquery-logo-dark.png?width=408&height=438&name=nquery-logo-dark.png 408w, https://www.statsols.com/hs-fs/hubfs/nquery-logo-dark.png?width=489&height=525&name=nquery-logo-dark.png 489w" sizes="(max-width: 163px) 100vw, 163px"></a></span> </div> </div> </div> <div class="w-1/2 sm:w-2/3 md:w-3/4 lg:w-5/6"> <div class="lg:hidden flex justify-end"> <div id="mobile-nav-trigger" class="cursor-pointer pr-4"> <div id="mobile-nav-close" class="hidden"> <svg class="w-[30px]" stroke="currentColor" fill="currentColor" stroke-width="0" viewbox="0 0 24 24" xmlns="http://www.w3.org/2000/svg"><path fill="none" stroke="#000" stroke-width="2" d="M3,3 L21,21 M3,21 L21,3"></path></svg> </div> <div id="mobile-nav-open"> <svg class="w-[30px]" stroke="currentColor" fill="currentColor" stroke-width="0" viewbox="0 0 512 512" xmlns="http://www.w3.org/2000/svg"><path d="M32 96v64h448V96H32zm0 128v64h448v-64H32zm0 128v64h448v-64H32z"></path></svg> </div> </div> </div> <div class="w-full hidden lg:flex flex-col lg:flex-row items-center absolute lg:static right-0 bg-white top-[65px] lg:top-[100px] lg:bg-transparent main-nav-menu pb-32 lg:pb-0 overflow-y-scroll lg:overflow-visible h-screen lg:h-full shadow-[0_3px_3px_rgba(0,0,0,0.1)] lg:shadow-none" id="main-nav-menu"> <div class="px-6 lg:px-0 w-full lg:w-2/3 mb-6 lg:mb-0 py-6 lg:py-0"> <div id="hs_cos_wrapper_main_nav" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module">  <ul class="flex flex-col lg:flex-row lg:items-center lg:justify-center lg:space-x-6 pl-0 list-none"> <li class="group m-0"> <div class="flex items-center relative"> <a href="https://www.statsols.com/nquery?hsLang=en-us" class="text-nq-forest lg:group-hover:text-nq-jade text-[16px] block py-3 lg:py-6 menu-item before:absolute before:bottom-[2px] before:left-0 before:w-full before:h-[2px] before:invisible before:scale-x-0 before:transition-all before:duration-200 before:ease-in-out before:origin-bottom before:content-[' '] lg:group-hover:before:visible lg:group-hover:before:scale-x-100 lg:group-hover:before:bg-nq-jade font-semibold lg:font-normal mb-3 lg:mb-0"> nQuery </a> <div class="px-1 hidden lg:block"> <svg class="origin-center duration-200 ease-in-out lg:group-hover:rotate-180 transition-transform" width="16" height="16" viewbox="0 0 16 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M4 6L8 10L12 6" stroke="black" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="relative lg:absolute left-0 w-full px-0 lg:p-6 bg-white z-10 lg:hidden group-hover:block lg:shadow-[0_3px_3px_rgba(0,0,0,0.1)]"> <div class="container "> <div class="flex flex-wrap"> <div class="w-full lg:px-6 mb-6 lg:mb-0 lg:w-2/5 "> <div> <div class="mb-3"> <p class="uppercase text-[12px] text-black/50 font-semibold">Solutions</p> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Sample Size & Power Calculations </a> </div> <div> <p class="text-black/60 text-[12px] group-hover/menu-item:text-black">Calculate for a Variety of frequentist and Bayesian Design</p> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/adapt" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Adaptive Design </a> </div> <div> <p class="text-black/60 text-[12px] group-hover/menu-item:text-black">Design and Analyze a Wide Range of Adaptive Designs</p> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/predict?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Milestone Prediction </a> </div> <div> <p class="text-black/60 text-[12px] group-hover/menu-item:text-black">Predict Interim Analysis Timing or Study Length</p> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/randomization?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Randomization Lists </a> </div> <div> <p class="text-black/60 text-[12px] group-hover/menu-item:text-black">Generate and Save Lists for your Trial Design</p> </div> </div> </div> </div> <div class="w-full lg:px-6 mb-6 lg:mb-0 lg:w-2/5 "> <div> <div class="mb-3"> <p class="uppercase text-[12px] text-black/50 font-semibold">Capabilities</p> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/group-sequential-design?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Group Sequential and Promising Zone Designs </a> </div> <div> <p class="text-black/60 text-[12px] group-hover/menu-item:text-black">Calculate Boundaries & Find Sample Size, Evaluate Interim Data & Re-estimate Sample Size</p> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/bayes?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Sample Size for Bayesian Statistics </a> </div> <div> <p class="text-black/60 text-[12px] group-hover/menu-item:text-black">Probability of Success (Assurance), Credible Intervals, Bayes Factors and more</p> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/early-stage-designs?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Early Stage and Complex Designs </a> </div> <div> <p class="text-black/60 text-[12px] group-hover/menu-item:text-black">Sample size & operating characteristics for Phase I, II & Seamless Designs (MAMS)</p> </div> </div> </div> </div> <div class="w-full lg:px-6 mb-6 lg:mb-0 lg:w-1/5 lg:flex lg:justify-end "> <div> <div class="mb-3"> <p class="uppercase text-[12px] text-black/50 font-semibold">Software</p> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/whats-new?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> What's New </a> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/pricing?hsLang=en-us#procedures" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Procedures </a> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/templates/download?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Templates </a> </div> </div> </div> </div> </div> </div> </div> </li> <li class="group m-0"> <div class="flex items-center relative"> <a href="https://www.statsols.com/customers-and-case-studies?hsLang=en-us" class="text-nq-forest lg:group-hover:text-nq-jade text-[16px] block py-3 lg:py-6 menu-item before:absolute before:bottom-[2px] before:left-0 before:w-full before:h-[2px] before:invisible before:scale-x-0 before:transition-all before:duration-200 before:ease-in-out before:origin-bottom before:content-[' '] lg:group-hover:before:visible lg:group-hover:before:scale-x-100 lg:group-hover:before:bg-nq-jade font-semibold lg:font-normal mb-3 lg:mb-0"> Customers </a> <div class="px-1 hidden lg:block"> </div> </div> </li> <li class="group m-0"> <div class="flex items-center relative"> <a href="https://www.statsols.com/sample-size-resources?hsLang=en-us" class="text-nq-forest lg:group-hover:text-nq-jade text-[16px] block py-3 lg:py-6 menu-item before:absolute before:bottom-[2px] before:left-0 before:w-full before:h-[2px] before:invisible before:scale-x-0 before:transition-all before:duration-200 before:ease-in-out before:origin-bottom before:content-[' '] lg:group-hover:before:visible lg:group-hover:before:scale-x-100 lg:group-hover:before:bg-nq-jade font-semibold lg:font-normal mb-3 lg:mb-0"> Resources </a> <div class="px-1 hidden lg:block"> <svg class="origin-center duration-200 ease-in-out lg:group-hover:rotate-180 transition-transform" width="16" height="16" viewbox="0 0 16 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M4 6L8 10L12 6" stroke="black" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="relative lg:absolute left-0 w-full px-0 lg:p-6 bg-white z-10 lg:hidden group-hover:block lg:shadow-[0_3px_3px_rgba(0,0,0,0.1)]"> <div class="container lg:px-6"> <div class="flex flex-wrap py-3"> <div class="w-full lg:w-1/3"></div> <div class="w-full lg:w-2/3"> <div class="flex flex-wrap"> <div class="w-full lg:w-1/2 mb-6 lg:mb-0"> <div class="mb-3"> <p class="uppercase text-[12px] text-black/50 font-semibold">Learn</p> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/nquery/how-to-use-nquery?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> How To Use nQuery </a> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/templates/download?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Trial Design Templates </a> </div> </div> <div class="mb-3"> <div> <a href="https://cta-service-cms2.hubspot.com/web-interactives/public/v1/track/click?encryptedPayload=AVxigLIC%2Fp3P0yNyTmzpo6GECv0%2Fm%2BOTgslLAgnlkdS1rp0HZZZ3ZNblvyKDComlloDtYppd3tZDJA8M5C5NGkYFMBOs17aXLG5KK6vL1J3XFpR4knlyUNc1n7rh3LmIKhn5iIdqfINBrroPHwrVoetQznNQs5iOci%2FCUginozvKRdTZVNodRJ1LtWj1yHUDheXg3Dj0MAOW1BnWB2Cru3utd%2BynB6EX%2FPDZXpI4helaeqUaG93WweTFgRKvnQi0zXBnLw%3D%3D&portalId=488764" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> nQuery User Manual </a> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/articles?hsLang=en-us#video-guides" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Video Guides </a> </div> </div> </div> <div class="w-full lg:w-1/2"> <div class="bg-[#F3F3EF] p-[32px] rounded-[6px] relative"> <div class=""> <div class="mb-[16px]"> <p class="text-[18px] text-nq-forest font-semibold"> Optimize Clinical Trial Design </p> </div> <div class="mb-[64px]"> <p class="text-[14px] text-nq-forest"> Sample size resources to design efficient, informative and ethical adaptive trials </p> </div> </div> <div class="absolute left-[32px] bottom-[32px]"> <a href="https://www.statsols.com/articles?hsLang=en-us" class="text-[#36AE8A] text-[14px]">Explore Resource Center ></a> </div> </div> </div> </div> </div> </div> </div> </div> </li> <li class="group m-0"> <div class="flex items-center relative"> <a href="https://www.statsols.com/nquery-sales-faq?hsLang=en-us#question" class="text-nq-forest lg:group-hover:text-nq-jade text-[16px] block py-3 lg:py-6 menu-item before:absolute before:bottom-[2px] before:left-0 before:w-full before:h-[2px] before:invisible before:scale-x-0 before:transition-all before:duration-200 before:ease-in-out before:origin-bottom before:content-[' '] lg:group-hover:before:visible lg:group-hover:before:scale-x-100 lg:group-hover:before:bg-nq-jade font-semibold lg:font-normal mb-3 lg:mb-0"> Contact </a> <div class="px-1 hidden lg:block"> <svg class="origin-center duration-200 ease-in-out lg:group-hover:rotate-180 transition-transform" width="16" height="16" viewbox="0 0 16 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M4 6L8 10L12 6" stroke="black" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="relative lg:absolute left-0 w-full px-0 lg:p-6 bg-white z-10 lg:hidden group-hover:block lg:shadow-[0_3px_3px_rgba(0,0,0,0.1)]"> <div class="container lg:px-6"> <div class="flex flex-wrap py-3"> <div class="w-full lg:w-1/3"></div> <div class="w-full lg:w-2/3"> <div class="flex flex-wrap"> <div class="w-full lg:w-1/2 mb-6 lg:mb-0"> <div class="mb-3"> <p class="uppercase text-[12px] text-black/50 font-semibold">support</p> </div> <div class="mb-3"> <div> <a href="https://knowledgebase.statsols.com/s/topic/0TO2X000000kZQ9WAM/licensing-support" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Licensing Support </a> </div> </div> <div class="mb-3"> <div> <a href="https://knowledgebase.statsols.com/s/topic/0TO2X000000kZQAWA2/technical-support" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Technical Support </a> </div> </div> <div class="mb-3"> <div> <a href="https://knowledgebase.statsols.com/login" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Login to Support </a> </div> </div> <div class="mb-3"> <div> <a href="https://www.statsols.com/how-to-log-a-support-ticket?hsLang=en-us" class="text-nq-forest hover:text-nq-jade text-[16px] block leading-snug mb-1 "> Submit Support Ticket </a> </div> </div> </div> <div class="w-full lg:w-1/2"> <div class="bg-[#F3F3EF] p-[32px] rounded-[6px] relative"> <div class=""> <div class="mb-[16px]"> <p class="text-[18px] text-nq-forest font-semibold"> Knowledge Base </p> </div> <div class="mb-[64px]"> <p class="text-[14px] text-nq-forest"> Find solutions to technical problems & submit a ticket here </p> </div> </div> <div class="absolute left-[32px] bottom-[32px]"> <a href="https://knowledgebase.statsols.com/s/" class="text-[#36AE8A] text-[14px]">Explore Help Center ></a> </div> </div> </div> </div> </div> </div> </div> </div> </li> </ul> </div> </div> <div class="w-full lg:w-1/3"> <div class="flex items-center lg:justify-end w-full space-x-4 px-6 lg:px-0"> <div> <a href="/nquery/pricing?hsLang=en-us" class="btn border-nq-jade text-[16px] text-nq-forest hover:text-nq-forest hover:bg-nq-jade">Pricing</a> </div> <div> <a href="/nquery-demo?hsLang=en-us" class="btn border-nq-jade text-[16px] text-nq-forest bg-nq-jade hover:text-nq-forest hover:bg-nq-jade/80">Free Trial</a> </div> </div> </div> </div> </div> </div> </div> </nav></div> <main id="main-content" class="body-container-wrapper"> <div class="container-fluid dnd-empty"> <div class="row-fluid-wrapper"> <div class="row-fluid"> <div class="span12 widget-span widget-type-cell " style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-1 dnd_area-row-0-vertical-alignment dnd_area-row-0-background-color dnd_area-row-0-background-layers dnd-section dnd_area-row-0-padding"> <div class="row-fluid "> <div class="span5 widget-span widget-type-cell cell_17050082350429-margin cell_17050082350429-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="0" data-w="5"> <div class="row-fluid-wrapper row-depth-1 row-number-2 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500823504215" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500823504215_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h1><span style="color: #ffffff;">Adaptive Clinical Trial Design Software</span></h1></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-3 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500823504216" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500823504216_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p style="font-size: 19px;"><span style="color: #ffffff;">Adaptive trials can reduce the length of your trial by up to 30%</span></p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-4 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500823504217" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="relative z-0 hidden lg:block"> <div class="absolute top-0 z-0" style="transform: translate(-158%, -140%); "> <img class="block" src="https://www.statsols.com/hs-fs/hubfs/Cookie-34.png?width=140&height=140&name=Cookie-34.png" alt="Cookie-34" loading="lazy" width="140" height="140" style="max-width: 100%; height: auto;" srcset="https://www.statsols.com/hs-fs/hubfs/Cookie-34.png?width=70&height=70&name=Cookie-34.png 70w, https://www.statsols.com/hs-fs/hubfs/Cookie-34.png?width=140&height=140&name=Cookie-34.png 140w, https://www.statsols.com/hs-fs/hubfs/Cookie-34.png?width=210&height=210&name=Cookie-34.png 210w, https://www.statsols.com/hs-fs/hubfs/Cookie-34.png?width=280&height=280&name=Cookie-34.png 280w, https://www.statsols.com/hs-fs/hubfs/Cookie-34.png?width=350&height=350&name=Cookie-34.png 350w, https://www.statsols.com/hs-fs/hubfs/Cookie-34.png?width=420&height=420&name=Cookie-34.png 420w" sizes="(max-width: 140px) 100vw, 140px"> </div> </div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500823504218" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="button-wrapper"> <a class="button" href="https://www.statsols.com/nquery-demo?hsLang=en-us"> Try for Free </a> </div></div> </div> </div> </div> </div> <div class="span7 widget-span widget-type-cell cell_170500823504210-padding cell_170500823504210-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="5" data-w="7"> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1706199325587" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="hs-video-widget" data-hsv-embed-id="69ad490e-c2e6-417b-9a0a-689d3411b2a8"> <div class="hs-video-container" style="margin: 0 auto;"> <div class="hs-video-wrapper" style="position: relative; height: 0; padding-bottom: 50.99%"> <iframe data-hsv-src="https://play.hubspotvideo.com/v/488764/id/154318878810?play_button_color=ffffff&autoplay=true&loop=true&muted=true" referrerpolicy="origin" sandbox="allow-forms allow-scripts allow-same-origin allow-popups" allow="autoplay; fullscreen;" style="position: absolute !important; width: 100% !important; height: 100% !important; left: 0; top: 0; border: 0 none; pointer-events: initial" title="HubSpot Video" loading="lazy" data-hsv-id="154318878810" data-hsv-play-button-color="ffffff" data-hsv-width="1920" data-hsv-height="979" data-hsv-autoplay="true" data-hsv-loop="true" data-hsv-muted="true" data-hsv-full-width="true"></iframe> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd_area-row-1-padding dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050082246975" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_17050082246975_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="text-align: center; font-size: 39px;">More efficient, informative & ethical adaptive clinical trials</h2></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-9 dnd_area-row-2-padding dnd-section stack-reverse dnd_area-row-2-max-width-section-centering dnd_area-row-2-vertical-alignment"> <div class="row-fluid "> <div class="span4 widget-span widget-type-cell cell_17050082792278-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="0" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500827922713" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500827922713_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3>Reduce Trial Costs</h3></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-11 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500827922714" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500827922714_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p>Use adaptive designs like group sequential design to facilitate early interim decisions to ensure an efficient and ethical  conclusion to your trial.</p></span></div> </div> </div> </div> </div> <div class="span8 widget-span widget-type-cell cell_17050082792279-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="4" data-w="8"> <div class="row-fluid-wrapper row-depth-1 row-number-12 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1705623659262" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image shadow-img" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1705623659262_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/grpsqtl-1-adaptive.png?width=1504&name=grpsqtl-1-adaptive.png" class="hs-image-widget " style="width:1504px;border-width:0px;border:0px;" width="1504" alt="grpsqtl-1-adaptive" title="grpsqtl-1-adaptive" srcset="https://www.statsols.com/hs-fs/hubfs/grpsqtl-1-adaptive.png?width=752&name=grpsqtl-1-adaptive.png 752w, https://www.statsols.com/hs-fs/hubfs/grpsqtl-1-adaptive.png?width=1504&name=grpsqtl-1-adaptive.png 1504w, https://www.statsols.com/hs-fs/hubfs/grpsqtl-1-adaptive.png?width=2256&name=grpsqtl-1-adaptive.png 2256w, https://www.statsols.com/hs-fs/hubfs/grpsqtl-1-adaptive.png?width=3008&name=grpsqtl-1-adaptive.png 3008w, https://www.statsols.com/hs-fs/hubfs/grpsqtl-1-adaptive.png?width=3760&name=grpsqtl-1-adaptive.png 3760w, https://www.statsols.com/hs-fs/hubfs/grpsqtl-1-adaptive.png?width=4512&name=grpsqtl-1-adaptive.png 4512w" sizes="(max-width: 1504px) 100vw, 1504px"></span> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd_area-row-3-max-width-section-centering dnd-section dnd_area-row-3-padding dnd_area-row-3-vertical-alignment"> <div class="row-fluid "> <div class="span8 widget-span widget-type-cell cell_17050082863148-vertical-alignment cell_17050082863148-margin dnd-column" style="" data-widget-type="cell" data-x="0" data-w="8"> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1705623681118" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image shadow-img" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1705623681118_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/adapt-2-ensure.png?width=1504&name=adapt-2-ensure.png" class="hs-image-widget " style="width:1504px;border-width:0px;border:0px;" width="1504" alt="adapt-2-ensure" title="adapt-2-ensure" srcset="https://www.statsols.com/hs-fs/hubfs/adapt-2-ensure.png?width=752&name=adapt-2-ensure.png 752w, https://www.statsols.com/hs-fs/hubfs/adapt-2-ensure.png?width=1504&name=adapt-2-ensure.png 1504w, https://www.statsols.com/hs-fs/hubfs/adapt-2-ensure.png?width=2256&name=adapt-2-ensure.png 2256w, https://www.statsols.com/hs-fs/hubfs/adapt-2-ensure.png?width=3008&name=adapt-2-ensure.png 3008w, https://www.statsols.com/hs-fs/hubfs/adapt-2-ensure.png?width=3760&name=adapt-2-ensure.png 3760w, https://www.statsols.com/hs-fs/hubfs/adapt-2-ensure.png?width=4512&name=adapt-2-ensure.png 4512w" sizes="(max-width: 1504px) 100vw, 1504px"></span> </div> </div> </div> </div> </div> <div class="span4 widget-span widget-type-cell cell_17050082863149-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="8" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-15 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500828631415" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500828631415_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3>Ensure Trial Success</h3></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-16 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500828631416" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500828631416_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p>Avoid under or overpowered trials by using sample size re-estimation to  adjust the sample size based on your blinded or unblinded interim results.</p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-17 dnd-section stack-reverse dnd_area-row-4-max-width-section-centering dnd_area-row-4-padding dnd_area-row-4-vertical-alignment"> <div class="row-fluid "> <div class="span5 widget-span widget-type-cell cell_17050082923648-vertical-alignment cell_17050082923648-margin dnd-column" style="" data-widget-type="cell" data-x="0" data-w="5"> <div class="row-fluid-wrapper row-depth-1 row-number-18 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500829236413" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500829236413_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3>Design Complex Trials</h3></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-19 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500829236414" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500829236414_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p>Investigate multiple treatments and dynamically drop or add trial arms using multi-arm, multi-stage (MAMS) designs</p></span></div> </div> </div> </div> </div> <div class="span7 widget-span widget-type-cell cell_17050082923649-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="5" data-w="7"> <div class="row-fluid-wrapper row-depth-1 row-number-20 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1705623706893" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image shadow-img" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1705623706893_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/adapt-3-design.png?width=1504&name=adapt-3-design.png" class="hs-image-widget " style="width:1504px;border-width:0px;border:0px;" width="1504" alt="adapt-3-design" title="adapt-3-design" srcset="https://www.statsols.com/hs-fs/hubfs/adapt-3-design.png?width=752&name=adapt-3-design.png 752w, https://www.statsols.com/hs-fs/hubfs/adapt-3-design.png?width=1504&name=adapt-3-design.png 1504w, https://www.statsols.com/hs-fs/hubfs/adapt-3-design.png?width=2256&name=adapt-3-design.png 2256w, https://www.statsols.com/hs-fs/hubfs/adapt-3-design.png?width=3008&name=adapt-3-design.png 3008w, https://www.statsols.com/hs-fs/hubfs/adapt-3-design.png?width=3760&name=adapt-3-design.png 3760w, https://www.statsols.com/hs-fs/hubfs/adapt-3-design.png?width=4512&name=adapt-3-design.png 4512w" sizes="(max-width: 1504px) 100vw, 1504px"></span> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-21 dnd-section dnd_area-row-5-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-22 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050080836147" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="button-wrapper"> <a class="button" href="https://www.statsols.com/nquery-demo?hsLang=en-us"> Get Started </a> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-23 dnd_area-row-6-padding dnd-section dnd_area-row-6-max-width-section-centering dnd_area-row-6-background-layers dnd_area-row-6-background-color"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-24 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050081261207" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_17050081261207_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="text-align: center; font-size: 39px;">Use nQuery Adapt to optimize your sample size for sophisticated adaptive clinical trials<span style="color: #515c62;"></span></h2></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-25 dnd_area-row-7-background-color dnd_area-row-7-background-layers dnd-section dnd_area-row-7-max-width-section-centering dnd_area-row-7-padding"> <div class="row-fluid "> <div class="span4 widget-span widget-type-cell cell_170500813490110-margin dnd-column" style="" data-widget-type="cell" data-x="0" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-26 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500813490115-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500813490115" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_170500813490115_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png" class="hs-image-widget " width="48" height="48" style="max-width: 100%; height: auto;" alt="circle-check" title="circle-check" loading="lazy" srcset="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=24&height=24&name=circle-check.png 24w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png 48w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=72&height=72&name=circle-check.png 72w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=96&height=96&name=circle-check.png 96w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=120&height=120&name=circle-check.png 120w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=144&height=144&name=circle-check.png 144w" sizes="(max-width: 48px) 100vw, 48px"></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-27 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500813490116" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500813490116_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3 style="font-size: 23px; margin-bottom: 18px;">Group Sequential Design</h3> <p>Stop trials early using spending function, Wang-Tsiatis, Haybittle-Peto and more</p></span></div> </div> </div> </div> </div> <div class="span4 widget-span widget-type-cell cell_170500813490111-padding dnd-column" style="" data-widget-type="cell" data-x="4" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-28 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module module_170500813490119-flexbox-positioning" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500813490119" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_170500813490119_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png" class="hs-image-widget " width="48" height="48" style="max-width: 100%; height: auto;" alt="circle-check" title="circle-check" loading="lazy" srcset="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=24&height=24&name=circle-check.png 24w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png 48w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=72&height=72&name=circle-check.png 72w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=96&height=96&name=circle-check.png 96w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=120&height=120&name=circle-check.png 120w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=144&height=144&name=circle-check.png 144w" sizes="(max-width: 48px) 100vw, 48px"></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-29 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500813490120" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500813490120_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3 style="font-size: 23px; margin-bottom: 18px;">Sample Size Re-estimation</h3> <p>Adjust sample size dynamically using promising zone or internal pilot designs</p></span></div> </div> </div> </div> </div> <div class="span4 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="8" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-30 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500813490123-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500813490123" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_170500813490123_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png" class="hs-image-widget " width="48" height="48" style="max-width: 100%; height: auto;" alt="circle-check" title="circle-check" loading="lazy" srcset="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=24&height=24&name=circle-check.png 24w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png 48w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=72&height=72&name=circle-check.png 72w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=96&height=96&name=circle-check.png 96w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=120&height=120&name=circle-check.png 120w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=144&height=144&name=circle-check.png 144w" sizes="(max-width: 48px) 100vw, 48px"></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-31 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500813490124" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500813490124_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3 style="font-size: 23px; margin-bottom: 18px;">Multi-Arm Multi-Stage (MAMS)</h3> <p>Evaluate multiple treatments while dropping or adding study arms</p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-32 dnd_area-row-8-max-width-section-centering dnd-section dnd_area-row-8-background-layers dnd_area-row-8-padding dnd_area-row-8-background-color"> <div class="row-fluid "> <div class="span4 widget-span widget-type-cell cell_170500814000810-margin dnd-column" style="" data-widget-type="cell" data-x="0" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-33 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500814000815-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500814000815" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_170500814000815_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png" class="hs-image-widget " width="48" height="48" style="max-width: 100%; height: auto;" alt="circle-check" title="circle-check" loading="lazy" srcset="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=24&height=24&name=circle-check.png 24w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png 48w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=72&height=72&name=circle-check.png 72w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=96&height=96&name=circle-check.png 96w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=120&height=120&name=circle-check.png 120w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=144&height=144&name=circle-check.png 144w" sizes="(max-width: 48px) 100vw, 48px"></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-34 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500814000816" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500814000816_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3 style="font-size: 23px; margin-bottom: 18px;">Adaptive Phase IIa Designs</h3> <p>Reject unpromising treatments faster using methods such as Simon’s Design</p></span></div> </div> </div> </div> </div> <div class="span4 widget-span widget-type-cell cell_170500814000811-padding dnd-column" style="" data-widget-type="cell" data-x="4" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-35 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500814000819-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500814000819" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_170500814000819_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png" class="hs-image-widget " width="48" height="48" style="max-width: 100%; height: auto;" alt="circle-check" title="circle-check" loading="lazy" srcset="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=24&height=24&name=circle-check.png 24w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png 48w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=72&height=72&name=circle-check.png 72w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=96&height=96&name=circle-check.png 96w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=120&height=120&name=circle-check.png 120w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=144&height=144&name=circle-check.png 144w" sizes="(max-width: 48px) 100vw, 48px"></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-36 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500814000820" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500814000820_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3 style="font-size: 23px; margin-bottom: 18px;">MCP-Mod</h3> <p>Combine Phase IIa/IIb evaluations for superior evidence for Phase II trials </p></span></div> </div> </div> </div> </div> <div class="span4 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="8" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-37 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500814000823-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500814000823" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_170500814000823_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png" class="hs-image-widget " width="48" height="48" style="max-width: 100%; height: auto;" alt="circle-check" title="circle-check" loading="lazy" srcset="https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=24&height=24&name=circle-check.png 24w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=48&height=48&name=circle-check.png 48w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=72&height=72&name=circle-check.png 72w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=96&height=96&name=circle-check.png 96w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=120&height=120&name=circle-check.png 120w, https://www.statsols.com/hs-fs/hubfs/circle-check.png?width=144&height=144&name=circle-check.png 144w" sizes="(max-width: 48px) 100vw, 48px"></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-38 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500814000824" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500814000824_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3 style="font-size: 23px; margin-bottom: 18px;">Conditional Power</h3> <p>Find the probability of success at each interim analysis</p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-39 dnd-section dnd_area-row-9-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-40 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500831361810" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500831361810_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="text-align: center; font-size: 39px;">Sample Size Platform for Adaptive Trials</h2> <p style="text-align: center;"><span style="color: #515c62;">From fixed to flexible group sequential designs, nQuery helps you confidently reduce the risk and cost of clinical trials</span></p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-41 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-42 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500831361813" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="hs-video-widget" data-hsv-embed-id="e5e1b019-5263-447a-98fb-87eb15dae0d2"> <div class="hs-video-container" style="max-width: 1920px; margin: 0 auto;"> <div class="hs-video-wrapper" style="position: relative; height: 0; padding-bottom: 56.25%"> <iframe data-hsv-src="https://play.hubspotvideo.com/v/488764/id/175773524663?play_button_color=ffffff" referrerpolicy="origin" sandbox="allow-forms allow-scripts allow-same-origin allow-popups" allow="autoplay; fullscreen;" style="position: absolute !important; width: 100% !important; height: 100% !important; left: 0; top: 0; border: 0 none; pointer-events: initial" title="HubSpot Video" loading="lazy" data-hsv-id="175773524663" data-hsv-play-button-color="ffffff" data-hsv-width="1920" data-hsv-height="1080" data-hsv-full-width="false"></iframe> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-43 dnd-section dnd_area-row-10-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-44 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050083256844" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="button-wrapper"> <a class="button" href="https://www.statsols.com/nquery-demo?hsLang=en-us"> Get Started </a> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-45 dnd-section dnd_area-row-11-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-46 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050081658157" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_17050081658157_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="text-align: center; font-size: 33px;">Frequently Asked Questions</h2> <p style="text-align: center;">Why nQuery is used for a wide range of adaptive designs</p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-47 dnd_area-row-12-padding dnd-section dnd_area-row-12-max-width-section-centering"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-48 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500818287510" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="bg-white faq-item px-3 py-3"> <div class="flex items-center justify-between cursor-pointer faq-question "> <div> <p class="text-[16px] font-semibold text-blue-primary"> What is nQuery Adapt? </p> </div> <div> <svg class="faq-closed" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M9 3.85254V14.3525M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> <svg class="faq-open hidden" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="hidden faq-answer text-nq-primary text-[16px] prose max-w-full prose-a:text-nq-jade mt-6"> <p>nQuery Adapt is the powerful adaptive module of the nQuery platform for clinical trial design.</p> <p>nQuery has 1000+ validated statistical procedures covering Adaptive, Bayesian and classical clinical trial designs.</p> <p>Browse the <a href="https://www.statsols.com/nquery-case-study/optimize-clinical-trials?hsLang=en-us" rel="noopener">tables for the Adaptive module in nQuery here</a>.</p> </div> </div> <div class="h-[4px] bg-nq-grey w-full"></div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-49 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500818287511" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="bg-white faq-item px-3 py-3"> <div class="flex items-center justify-between cursor-pointer faq-question "> <div> <p class="text-[16px] font-semibold text-blue-primary"> How do I take a trial? </p> </div> <div> <svg class="faq-closed" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M9 3.85254V14.3525M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> <svg class="faq-open hidden" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="hidden faq-answer text-nq-primary text-[16px] prose max-w-full prose-a:text-nq-jade mt-6"> <p><span>You can take a</span><span> </span><a href="https://www.statsols.com/nquery-demo?hsLang=en-us" rel="noopener">free 14-day nQuery here.</a></p> </div> </div> <div class="h-[4px] bg-nq-grey w-full"></div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-50 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500818287512" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="bg-white faq-item px-3 py-3"> <div class="flex items-center justify-between cursor-pointer faq-question "> <div> <p class="text-[16px] font-semibold text-blue-primary"> How do I purchase? </p> </div> <div> <svg class="faq-closed" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M9 3.85254V14.3525M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> <svg class="faq-open hidden" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="hidden faq-answer text-nq-primary text-[16px] prose max-w-full prose-a:text-nq-jade mt-6"> <p><span>nQuery Adapt is included in our <strong><em>Pro Tier</em></strong>.</span></p> <p><span>In addition to the Adapt module, you also have access to all the popular frequentists and a Bayesian trial design functionality. With access to over 1000+ sample size scenarios. </span><br><a href="https://www.statsols.com/nquery/request-a-quote?hsLang=en-us" rel="noopener">You can purchase online here.</a></p> <p><strong><span>Have A Question?</span><br></strong><a href="https://www.statsols.com/nquery-sales-faq?hsLang=en-us#question" rel="noopener">You can get in contact with us here.</a></p> </div> </div> <div class="h-[4px] bg-nq-grey w-full"></div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-51 dnd_area-row-13-padding dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-52 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050081716915" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_17050081716915_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="text-align: center; font-size: 33px;">More about the Adaptive module in nQuery</h2></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-53 dnd_area-row-14-max-width-section-centering dnd-section dnd_area-row-14-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-54 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500819703713" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="bg-white faq-item px-3 py-3"> <div class="flex items-center justify-between cursor-pointer faq-question "> <div> <p class="text-[16px] font-semibold text-blue-primary"> Are Adaptive designs more efficient? </p> </div> <div> <svg class="faq-closed" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M9 3.85254V14.3525M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> <svg class="faq-open hidden" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="hidden faq-answer text-nq-primary text-[16px] prose max-w-full prose-a:text-nq-jade mt-6"> <h4><span>Are Adaptive designs more efficient?</span></h4> <p><span>Adaptive designs allow clinical trials to be more flexible by utilising results accumulated in the trial to change the trial’s course. <em><strong>Trials with an adaptive design are usually more efficient, informative and can be more ethical than trials that have a traditional fixed design because they often make better use of resources such as time and money, and may require fewer participants.</strong></em><br><br>Adaptive designs can also be potentially less efficient than a fixed term trial or simple adaptive design if designed poorly. For example, sample size re-estimation designs lead to higher average sample sizes for minimal success rate increases or adaptive selection designs which include additional arms with minimal prior chance of succeeding.<br><br>Overall, adaptive designs when properly considered and well-planned have considerable scope for increasing trial efficiency but the additional flexibility could mean more opportunities for making poor design decisions.</span></p> <p><span><strong>Recommended:<br><a href="https://blog.statsols.com/an-introduction-to-adaptive-clinical-trial-designs?hsLang=en-us" rel="noopener">An Introduction to Adaptive Clinical Trial Designs</a></strong></span></p> </div> </div> <div class="h-[4px] bg-nq-grey w-full"></div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-55 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500819703714" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="bg-white faq-item px-3 py-3"> <div class="flex items-center justify-between cursor-pointer faq-question "> <div> <p class="text-[16px] font-semibold text-blue-primary"> What is a Group Sequential Design? </p> </div> <div> <svg class="faq-closed" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M9 3.85254V14.3525M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> <svg class="faq-open hidden" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="hidden faq-answer text-nq-primary text-[16px] prose max-w-full prose-a:text-nq-jade mt-6"> <h5><span>What is a Group Sequential Design?</span></h5> <p><span><a href="/nquery/group-sequential-design?hsLang=en-us" rel="noopener">Group sequential designs</a> are the most widely used type of adaptive trial in confirmatory Phase III clinical trials. </span><span>Group sequential designs differ from a standard fixed term trial by allowing a trial to end early based on pre-specified interim analyses for efficacy or futility. Group sequential designs achieve this by using an error spending method that allows a set amount of the total Type I (efficacy) or Type II (futility) error at each interim analysis. The ability to end the trial can help reduce costs by creating an opportunity to get early approval for highly effective treatments and abandoning trials that have shown very poor results thus far.</span></p> <h5><span>What is the assessment of futility in clinical trials?</span></h5> <p><span>The term 'futility' refers to the inability of a clinical trial to achieve its aims, such as, ending a clinical trial when the interim results suggest that it is highly unlikely to achieve statistical significance. This can save resources which can then be used in other more promising studies.</span><br><br></p> <p><span><strong>Recommended:</strong></span><br><span><a href="https://blog.statsols.com/an-introduction-to-adaptive-clinical-trial-designs?hsLang=en-us" rel="noopener">An Introduction to Adaptive Clinical Trial Designs</a></span></p> </div> </div> <div class="h-[4px] bg-nq-grey w-full"></div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-56 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500819703715" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="bg-white faq-item px-3 py-3"> <div class="flex items-center justify-between cursor-pointer faq-question "> <div> <p class="text-[16px] font-semibold text-blue-primary"> What is sample size re-estimation (SSR)? </p> </div> <div> <svg class="faq-closed" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M9 3.85254V14.3525M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> <svg class="faq-open hidden" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="hidden faq-answer text-nq-primary text-[16px] prose max-w-full prose-a:text-nq-jade mt-6"> <h4><span>What is sample size re-estimation (SSR)?</span></h4> <h5><span>Sample size r-estimation (SSR) is a type of adaptive trial where one can change the sample size if required. Sample size determination is a pre-trial process that will be conducted on the basis of inherently uncertain planning parameters (e.g. variance, effect size) and thus changing the sample size based on improved interim estimates for these parameters is an obvious adaptation target.</span><br><br><span>SSR can ensure that sufficient power is obtained for promising results in an underpowered study or could ensure more patients receive the superior treatment or transition directly from one trial phase to another. Combined this may reduce the use of resources and time or improve the likelihood of success of the trial.</span><br><br><span>There are two primary types of SSR: Unblinded SSR and Blinded SSR. The main differences between these designs are that they differ on whether the data is blinded or not and the planning parameter targeted to for an improved interim estimate.</span><br><br></h5> <p><span><strong>Recommended Viewing:</strong></span><br><strong><a href="https://blog.statsols.com/how-to-calculate-blinded-sample-size-re-estimation-in-clinical-trials?hsLang=en-us" rel="noopener">Blinded Sample Size Re-Estimation in Clinical Trials</a></strong></p> </div> </div> <div class="h-[4px] bg-nq-grey w-full"></div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-57 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500819703716" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="bg-white faq-item px-3 py-3"> <div class="flex items-center justify-between cursor-pointer faq-question "> <div> <p class="text-[16px] font-semibold text-blue-primary"> Conditional vs Predictive power? </p> </div> <div> <svg class="faq-closed" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M9 3.85254V14.3525M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> <svg class="faq-open hidden" width="18" height="19" viewbox="0 0 18 19" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M3.75 9.10254H14.25" stroke="#152430" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </div> <div class="hidden faq-answer text-nq-primary text-[16px] prose max-w-full prose-a:text-nq-jade mt-6"> <h4><span><strong>What is conditional power?</strong></span></h4> <p><span>Conditional power is the probability that the trial will reject the null hypothesis at a subsequent look given the current test statistic and the assumed “true”  parameter values, which are usually assumed to equal their interim estimates or their initial planning values. </span></p> <h4><span><strong>What is predictive power?</strong></span></h4> <p><span>Predictive power (also known as Bayesian Predictive Power) is the conditional power averaged over the posterior distribution of the effect size. It is commonly used to quantify the probability of success of a clinical trial. It has been suggested as a superior alternative to conditional power as it treats the “true” estimates as uncertain rather than fixed.</span></p> <h4><strong><span>Recommended:</span><br><span><a href="https://blog.statsols.com/an-introduction-to-adaptive-clinical-trial-designs?hsLang=en-us" rel="noopener">An Introduction to Adaptive Clinical Trial Designs</a></span></strong></h4> </div> </div> <div class="h-[4px] bg-nq-grey w-full"></div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-58 dnd-section dnd_area-row-15-background-color dnd_area-row-15-padding dnd_area-row-15-background-layers"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-59 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050080566475" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_17050080566475_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="text-align: center;">Recommended Resources</h2></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-60 dnd_area-row-16-background-layers dnd_area-row-16-padding dnd-section dnd_area-row-16-background-color"> <div class="row-fluid "> <div class="span4 widget-span widget-type-cell cell_17050080620963-margin dnd-column cell_17050080620963-padding" style="" data-widget-type="cell" data-x="0" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-61 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050080620967" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="overflow-hidden border border-[#DBDFD4] relative max-w-[380px] mx-auto"> <div> <div class="md:h-[200px]"> <a href="https://blog.statsols.com/?hsLang=en-us"> <img class="w-full h-full object-cover" src="https://www.statsols.com/hubfs/Expert%20Insights-3.png" alt="Expert Insights" loading="lazy"> </a> </div> <div class="p-[24px] bg-white relative"> <div class="mb-3"> <p class="m-0 text-xs text-nq-forest font-semibold bg-[#DBDFD4] px-[8px] py-[4px] inline-block">Expert Insights</p> </div> <div class="mb-3"> <p class=" font-semibold text-nq-forest max-lines max-lines-2 leading-normal"> </p> </div> <a href="https://blog.statsols.com/?hsLang=en-us" class="flex items-center mt-3 group"> <div class=""> <p class="text-sm text-nq-forest font-semibold">Watch Now</p> </div> <div class="px-1"><svg class="group-hover:translate-x-0.5 transition-transform duration-200" width="17" height="16" viewbox="0 0 17 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.5 4L10.5 8L6.5 12" stroke="#2EC99B" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="span4 widget-span widget-type-cell cell_17050080620964-padding dnd-column" style="" data-widget-type="cell" data-x="4" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-62 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17050080620969" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="overflow-hidden border border-[#DBDFD4] relative max-w-[380px] mx-auto"> <div> <div class="md:h-[200px]"> <a href="https://www.statsols.com/templates/download?hsLang=en-us"> <img class="w-full h-full object-cover" src="https://www.statsols.com/hubfs/Trial%20Design%20Templates-2-1.png" alt="Trial Design Templates-" loading="lazy"> </a> </div> <div class="p-[24px] bg-white relative"> <div class="mb-3"> <p class="m-0 text-xs text-nq-forest font-semibold bg-[#DBDFD4] px-[8px] py-[4px] inline-block">Trial Design Templates</p> </div> <div class="mb-3"> <p class=" font-semibold text-nq-forest max-lines max-lines-2 leading-normal"> </p> </div> <a href="https://www.statsols.com/templates/download?hsLang=en-us" class="flex items-center mt-3 group"> <div class=""> <p class="text-sm text-nq-forest font-semibold">Trial Design Templates</p> </div> <div class="px-1"><svg class="group-hover:translate-x-0.5 transition-transform duration-200" width="17" height="16" viewbox="0 0 17 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.5 4L10.5 8L6.5 12" stroke="#2EC99B" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="span4 widget-span widget-type-cell cell_17050080620965-padding dnd-column" style="" data-widget-type="cell" data-x="8" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-63 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500806209611" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="overflow-hidden border border-[#DBDFD4] relative max-w-[380px] mx-auto"> <div> <div class="md:h-[200px]"> <a href="https://blog.statsols.com/designing-robust-group-sequential-trials?hsLang=en-us"> <img class="w-full h-full object-cover" src="https://www.statsols.com/hubfs/Free%20Training-3.png" alt="Free Training" loading="lazy"> </a> </div> <div class="p-[24px] bg-white relative"> <div class="mb-3"> <p class="m-0 text-xs text-nq-forest font-semibold bg-[#DBDFD4] px-[8px] py-[4px] inline-block">Free Training</p> </div> <div class="mb-3"> <p class=" font-semibold text-nq-forest max-lines max-lines-2 leading-normal"> </p> </div> <a href="https://blog.statsols.com/designing-robust-group-sequential-trials?hsLang=en-us" class="flex items-center mt-3 group"> <div class=""> <p class="text-sm text-nq-forest font-semibold">Watch Now</p> </div> <div class="px-1"><svg class="group-hover:translate-x-0.5 transition-transform duration-200" width="17" height="16" viewbox="0 0 17 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M6.5 4L10.5 8L6.5 12" stroke="#2EC99B" stroke-width="2" stroke-linecap="square" stroke-linejoin="round" /> </svg> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-64 dnd_area-row-17-padding dnd_area-row-17-background-color dnd-section dnd_area-row-17-background-layers"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-65 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500841085413" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_170500841085413_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="text-align: center; font-size: 33px;">Get started with nQuery today</h2> <p style="text-align: center;">Start for free and upgrade as your team grows</p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-66 cell_17050084108549-row-1-vertical-alignment cell_17050084108549-row-1-hidden dnd-row"> <div class="row-fluid "> <div class="span6 widget-span widget-type-cell cell_170500841085414-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="0" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-67 cell_170500841085414-row-0-vertical-alignment dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module module_170500841085417-vertical-alignment" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500841085417" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="button-wrapper"> <a class="button" href="https://www.statsols.com/nquery-demo?hsLang=en-us"> Get Started </a> </div></div> </div> </div> </div> </div> <div class="span6 widget-span widget-type-cell cell_170500841085415-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="6" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-68 cell_170500841085415-row-0-vertical-alignment dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500841085419-vertical-alignment dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500841085419" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="button-wrapper"> <a class="button" href="https://www.statsols.com/nquery-sales-faq?hsLang=en-us"> Contact Us </a> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-69 cell_17050084108549-row-2-vertical-alignment cell_17050084108549-row-2-hidden dnd-row"> <div class="row-fluid "> <div class="span6 widget-span widget-type-cell cell_170500841085420-padding dnd-column cell_170500841085420-vertical-alignment" style="" data-widget-type="cell" data-x="0" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-70 cell_170500841085420-row-0-vertical-alignment dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500841085423-vertical-alignment dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500841085423" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="button-wrapper"> <a class="button" href="https://www.statsols.com/nquery-demo?hsLang=en-us"> Get Started </a> </div></div> </div> </div> </div> </div> <div class="span6 widget-span widget-type-cell cell_170500841085421-padding dnd-column cell_170500841085421-vertical-alignment" style="" data-widget-type="cell" data-x="6" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-71 cell_170500841085421-row-0-vertical-alignment dnd-row cell_170500841085421-row-0-hidden"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_170500841085425-vertical-alignment dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_170500841085425" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="button-wrapper"> <a class="button" href="https://www.statsols.com/nquery-sales-faq?hsLang=en-us"> Contact Us </a> </div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <div data-global-resource-path="nquery-theme/cli-build/partials/footer.html"> <footer class="bg-white py-20 relative border-t"> <div class="container relative px-6"> <div class="flex flex-wrap pb-12 border-b"> <div class="w-full lg:w-10/12"> <div class="flex flex-wrap justify-between"> <div class="w-1/2 sm:w-1/3 md:w-1/6 mb-6"> <p class="text-nq-forest hover:text-nq-forest text-[16px] no-underline font-bold block mb-3 hover:no-underline"> Product </p> <ul class="m-0 p-0 list-none"> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/whats-new?hsLang=en-us">What's new </a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery/pricing?hsLang=en-us">Plans</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="/nquery/pricing#procedures">Procedures</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery-demo?hsLang=en-us"> Get started</a> </li> </ul> </div> <div class="w-1/2 sm:w-1/3 md:w-1/6 mb-6"> <p class="text-nq-forest hover:text-nq-forest text-[16px] no-underline font-bold block mb-3 hover:no-underline"> Trial Solutions </p> <ul class="m-0 p-0 list-none"> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery?hsLang=en-us">Classical</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery/bayes?hsLang=en-us">Bayesian</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery/adapt">Adaptive</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery/predict?hsLang=en-us">Prediction</a> </li> </ul> </div> <div class="w-1/2 sm:w-1/3 md:w-1/6 mb-6"> <p class="text-nq-forest hover:text-nq-forest text-[16px] no-underline font-bold block mb-3 hover:no-underline"> Contact </p> <ul class="m-0 p-0 list-none"> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery/pricing?hsLang=en-us">Pricing</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery-sales-faq?hsLang=en-us">Talk to us</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery-sales-faq?hsLang=en-us#faq">FAQ</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://knowledgebase.statsols.com/s/support">Support</a> </li> </ul> </div> <div class="w-1/2 sm:w-1/3 md:w-1/6 mb-6"> <p class="text-nq-forest hover:text-nq-forest text-[16px] no-underline font-bold block mb-3 hover:no-underline"> Resources </p> <ul class="m-0 p-0 list-none"> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/nquery/how-to-use-nquery?hsLang=en-us">Training</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/templates/download?hsLang=en-us">Templates </a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/guides?hsLang=en-us">Webinars</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/articles?hsLang=en-us">Blog</a> </li> </ul> </div> <div class="w-1/2 sm:w-1/3 md:w-1/6 mb-6"> <p class="text-nq-forest hover:text-nq-forest text-[16px] no-underline font-bold block mb-3 hover:no-underline"> Company </p> <ul class="m-0 p-0 list-none"> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.statsols.com/statsols-about?hsLang=en-us">About us </a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.dotmatics.com/about-careers">Careers </a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.dotmatics.com/portfolio">Portfolio</a> </li> <li class="mb-2"> <a class="text-nq-forest text-[16px] inline-block no-underline hover:no-underline hover:text-nq-jade leading-normal" href="https://www.dotmatics.com/">Dotmatics</a> </li> </ul> </div> </div> </div> <div class="w-1/3 sm:w-1/2 md:w-5/12 lg:w-2/12"> <div class="mb-4"> <div id="hs_cos_wrapper_footer_logo" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-logo" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_footer_logo_hs_logo_widget" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_logo" style="" data-hs-cos-general-type="widget" data-hs-cos-type="logo"><a href="https://www.statsols.com/?hsLang=en-us" id="hs-link-footer_logo_hs_logo_widget" style="border-width:0px;border:0px;"><img src="https://www.statsols.com/hs-fs/hubfs/nQuery%20Logo.png?width=798&height=175&name=nQuery%20Logo.png" class="hs-image-widget " height="175" style="height: auto;width:798px;border-width:0px;border:0px;" width="798" alt="nQuery Logo" title="nQuery Logo" srcset="https://www.statsols.com/hs-fs/hubfs/nQuery%20Logo.png?width=399&height=88&name=nQuery%20Logo.png 399w, https://www.statsols.com/hs-fs/hubfs/nQuery%20Logo.png?width=798&height=175&name=nQuery%20Logo.png 798w, https://www.statsols.com/hs-fs/hubfs/nQuery%20Logo.png?width=1197&height=263&name=nQuery%20Logo.png 1197w, https://www.statsols.com/hs-fs/hubfs/nQuery%20Logo.png?width=1596&height=350&name=nQuery%20Logo.png 1596w, https://www.statsols.com/hs-fs/hubfs/nQuery%20Logo.png?width=1995&height=438&name=nQuery%20Logo.png 1995w, https://www.statsols.com/hs-fs/hubfs/nQuery%20Logo.png?width=2394&height=525&name=nQuery%20Logo.png 2394w" sizes="(max-width: 798px) 100vw, 798px"></a></span> </div> </div> <div class="mb-2"> <div id="hs_cos_wrapper_footer_copyright" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_footer_copyright_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p class="text-[16px]"><a href="https://www.statsols.com/privacy-policy?hsLang=en-us" class="text-[16px] text-nq-forest" rel="noopener">Privacy Policy</a></p></span></div> </div> <div class="mb-2"> <div id="hs_cos_wrapper_footer_privacy_policy" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_footer_privacy_policy_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p class="text-[16px]"><a href="https://www.statsols.com/license-agreement?hsLang=en-us" class="text-[16px] text-nq-forest" rel="noopener">License Agreement</a></p></span></div> </div> <div class="mb-2"> <div id="hs_cos_wrapper_footer_legal" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_footer_legal_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><a href="https://www.statsols.com/legal-disclaimers?hsLang=en-us" class="text-[16px] text-nq-forest" rel="noopener">Legal Disclaimers</a></span></div> </div> <div> <div id="hs_cos_wrapper_footer_security" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_footer_security_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><a href="https://www.dotmatics.com/trademarks" class="text-[16px] text-nq-forest" rel="noopener">Trademarks</a></span></div> </div> </div> </div> <div class="pt-6"> <div id="hs_cos_wrapper_location" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_location_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p class="text-sm mb-3"><strong>Location</strong>: GraphPad Software DBA Statistical Solutions, 225 Franklin St FL 26 Boston, MA, 02110-2853, United States</p></span></div> <p class="text-xs mb-3"> Copyright © 2024 Statsols. All Rights Reserved. </p> <div id="hs_cos_wrapper_footer_legal_links" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_footer_legal_links_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p class="text-xs"><a href="https://donotsell.dotmatics.com/hc/en-us/requests/new" rel="noopener" target="_blank" class="underline ">Do Not Sell or Share My Personal Information</a></p></span></div> </div> </div> </footer></div> </div>  <script defer src="/hs/hsstatic/content-cwv-embed/static-1.1293/embed.js"></script> <script src="https://www.statsols.com/hs-fs/hub/488764/hub_generated/template_assets/130521435917/1723206764894/nquery-theme/cli-build/js/main.min.js"></script> <script> var hsVars = hsVars || {}; hsVars['language'] = 'en-us'; </script> <script src="/hs/hsstatic/cos-i18n/static-1.53/bundles/project.js"></script> <script src="https://www.statsols.com/hs-fs/hub/488764/hub_generated/module_assets/160559318289/1726837308998/module_160559318289_main-nav.min.js"></script> <script src="https://cdn2.hubspot.net/hub/-1/hub_generated/module_assets/-35056501883/1731934114504/module_-35056501883_Video.min.js"></script>  <script async data-hs-portal-id="488764" data-hs-ignore="true" data-cookieconsent="ignore" data-hs-page-id="6492385781" src="https://static.hsappstatic.net/video-embed/ex/loader.js"></script> <script src="https://www.statsols.com/hs-fs/hub/488764/hub_generated/module_assets/130951228707/1692540901848/module_130951228707_faq.min.js"></script>  <script type="text/javascript"> var _hsq = _hsq || []; _hsq.push(["setContentType", "standard-page"]); _hsq.push(["setCanonicalUrl", "https:\/\/www.statsols.com\/nquery\/adapt"]); _hsq.push(["setPageId", "6492385781"]); _hsq.push(["setContentMetadata", { "contentPageId": 6492385781, "legacyPageId": "6492385781", "contentFolderId": null, "contentGroupId": null, "abTestId": null, "languageVariantId": 6492385781, "languageCode": "en-us", }]); </script> <script type="text/javascript" id="hs-script-loader" async defer src="/hs/scriptloader/488764.js"></script>  <script type="text/javascript"> var hsVars = { render_id: "80ed3209-9063-4749-bed9-2f0b953d14a3", ticks: 1731949506932, page_id: 6492385781, content_group_id: 0, portal_id: 488764, app_hs_base_url: "https://app.hubspot.com", cp_hs_base_url: "https://cp.hubspot.com", language: "en-us", analytics_page_type: "standard-page", scp_content_type: "", analytics_page_id: "6492385781", category_id: 1, folder_id: 0, is_hubspot_user: false } </script> <script defer src="/hs/hsstatic/HubspotToolsMenu/static-1.354/js/index.js"></script>  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MW5Q269" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>    </body></html>

CINXE.COM

Adaptive Clinical Trial Design with nQuery