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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125338049/A_Metabolomics_Study_of_Hypoxia_Ischemia_during_Mouse_Brain_Development_Using_Hyperpolarized_13C"><img alt="Research paper thumbnail of A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C" class="work-thumbnail" src="https://attachments.academia-assets.com/119400358/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125338049/A_Metabolomics_Study_of_Hypoxia_Ischemia_during_Mouse_Brain_Development_Using_Hyperpolarized_13C">A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C</a></div><div class="wp-workCard_item"><span>Developmental Neuroscience</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism. Methods: Mice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31. We used hyperpolarized 13C MRS to investigate the metabolic exchange of pyruvate to lactate in real time during brain development following HI. 13C-1-labeled pyruvate was hyperpolarized and injected into the tail vein through a tail-vein catheter. Chemical-shift imaging was performed to acquire spectral-spatial information of the metabolites in the brain. A voxel placed on each of the injured and contralateral hemispheres was chosen for comparison. The difference in pyruvate delivery and lactate to pyruvate ratio was calculated for each of the voxels at each time point. The normalized lactate level of the injured hemisphere was also calculated for each mouse at each ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="791f4c7abd6fa59f35dc7ade0d09dfe9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119400358,"asset_id":125338049,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/119400358/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125338049"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125338049"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125338049; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125338049]").text(description); $(".js-view-count[data-work-id=125338049]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125338049; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125338049']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125338049, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "791f4c7abd6fa59f35dc7ade0d09dfe9" } } $('.js-work-strip[data-work-id=125338049]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125338049,"title":"A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C","translated_title":"","metadata":{"abstract":"Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism. 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125338047/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia">HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia</a></div><div class="wp-workCard_item"><span>Developmental Neuroscience</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HI...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HIF-1α) may promote cell survival in hypoxic or ischemic brain. To help understand the role of HIF-1α in neonatal hypoxic-ischemic brain injury, mice with conditional neuron-specific inactivation of HIF-1α underwent hypoxia-ischemia (HI). Mice heterozygous for Cre recombinase under the control of the calcium/calmodulin-dependent kinase II promoter were bred with homozygous ‘floxed’ HIF-1α transgenic mice. The resulting litters produced mice with a forebrain predominant neuronal deletion of HIF-1α (HIF-1αΔ/Δ), as well as littermates without the deletion. In order to verify reduction of HIF-1α at postnatal day 7, HIF-1αΔ/Δ and wild-type mice were exposed to a hypoxic stimulus (8% oxygen) or room air for 1 h, followed by immediate collection of brain cortices for determination of HIF-1α expression. Results of Western blotting of mouse cortices exposed to hypoxia stimulus or room air confirmed...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f3c87fbfb6c7bc5d11c178647c4802f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119400357,"asset_id":125338047,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/119400357/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125338047"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125338047"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125338047; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125338047]").text(description); $(".js-view-count[data-work-id=125338047]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125338047; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125338047']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125338047, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f3c87fbfb6c7bc5d11c178647c4802f" } } $('.js-work-strip[data-work-id=125338047]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125338047,"title":"HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HIF-1α) may promote cell survival in hypoxic or ischemic brain. 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href="https://www.academia.edu/106439721/Failure_to_complete_apoptosis_following_neonatal_hypoxia_ischemia_manifests_as_continuum_phenotype_of_cell_death_and_occurs_with_multiple_manifestations_of_mitochondrial_dysfunction_in_rodent_forebrain"><img alt="Research paper thumbnail of Failure to complete apoptosis following neonatal hypoxia–ischemia manifests as “continuum” phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain" class="work-thumbnail" src="https://attachments.academia-assets.com/105637027/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" 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profile--work_container" data-work-id="61229329"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229329/The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia"><img alt="Research paper thumbnail of The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia" class="work-thumbnail" src="https://attachments.academia-assets.com/74332951/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229329/The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia">The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia</a></div><div class="wp-workCard_item"><span>Developmental Neuroscience</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular dysfunction, inflammation, and oxidative stress, followed later by tissue repair. The key enzyme of these processes in the human body is arginase (ARG) that acts via the bioavailability of nitric oxide, and the synthesis of polyamines and proline. ARG is expressed throughout the brain in different cells. However, little is known about the effect of ARG in pathophysiological states of the brain, especially hypoxia-ischemia. Here, we summarize the role of ARG during neurodevelopment as well as in various brain pathologies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7bb79997b2d30747e6d8cce36abc4851" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74332951,"asset_id":61229329,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74332951/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229329"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229329"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229329; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229329]").text(description); $(".js-view-count[data-work-id=61229329]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229329; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229329']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229329, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7bb79997b2d30747e6d8cce36abc4851" } } $('.js-work-strip[data-work-id=61229329]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229329,"title":"The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular dysfunction, inflammation, and oxidative stress, followed later by tissue repair. The key enzyme of these processes in the human body is arginase (ARG) that acts via the bioavailability of nitric oxide, and the synthesis of polyamines and proline. ARG is expressed throughout the brain in different cells. However, little is known about the effect of ARG in pathophysiological states of the brain, especially hypoxia-ischemia. Here, we summarize the role of ARG during neurodevelopment as well as in various brain pathologies.","publisher":"S. Karger AG","publication_name":"Developmental Neuroscience"},"translated_abstract":"Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular dysfunction, inflammation, and oxidative stress, followed later by tissue repair. The key enzyme of these processes in the human body is arginase (ARG) that acts via the bioavailability of nitric oxide, and the synthesis of polyamines and proline. ARG is expressed throughout the brain in different cells. However, little is known about the effect of ARG in pathophysiological states of the brain, especially hypoxia-ischemia. Here, we summarize the role of ARG during neurodevelopment as well as in various brain pathologies.","internal_url":"https://www.academia.edu/61229329/The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia","translated_internal_url":"","created_at":"2021-11-07T13:26:51.913-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74332951,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74332951/thumbnails/1.jpg","file_name":"496467.pdf","download_url":"https://www.academia.edu/attachments/74332951/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Arginase_Pathway_in_Neonatal_Brain_H.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74332951/496467-libre.pdf?1636320610=\u0026response-content-disposition=attachment%3B+filename%3DThe_Arginase_Pathway_in_Neonatal_Brain_H.pdf\u0026Expires=1732410262\u0026Signature=CiOJgsvMMeszDG~S3cAaWFjuV0QLevhhP2LUA1YI9RbMTTUfFQLLVRqLOe8mpT4-OjU-YnlwjIpEcz6XBJ~MRM7bt6ypLyP1konvW0QYDXAknq9UOSmxdxlGUDS26VirZ3R1NDxrchexYSTeOv57si-nJW5DMcvr0zZ3-waWiVZ6co1GLF8r2Yeroj2iN47CLE20q-d7Wy~fPSz7QwbPOY~bS1RzzNEwsOTUMFjENIwcQRbq9Y81-H1He6qvotpJyWpzAJv6igOzcAvQnoyDOSuT1WafpbDrNV7QQe1i0ibSfg7Jhex95ja06XHwrWkDcGPDa0C2hzrM6RwVIlXlOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74332951,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74332951/thumbnails/1.jpg","file_name":"496467.pdf","download_url":"https://www.academia.edu/attachments/74332951/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Arginase_Pathway_in_Neonatal_Brain_H.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74332951/496467-libre.pdf?1636320610=\u0026response-content-disposition=attachment%3B+filename%3DThe_Arginase_Pathway_in_Neonatal_Brain_H.pdf\u0026Expires=1732410262\u0026Signature=CiOJgsvMMeszDG~S3cAaWFjuV0QLevhhP2LUA1YI9RbMTTUfFQLLVRqLOe8mpT4-OjU-YnlwjIpEcz6XBJ~MRM7bt6ypLyP1konvW0QYDXAknq9UOSmxdxlGUDS26VirZ3R1NDxrchexYSTeOv57si-nJW5DMcvr0zZ3-waWiVZ6co1GLF8r2Yeroj2iN47CLE20q-d7Wy~fPSz7QwbPOY~bS1RzzNEwsOTUMFjENIwcQRbq9Y81-H1He6qvotpJyWpzAJv6igOzcAvQnoyDOSuT1WafpbDrNV7QQe1i0ibSfg7Jhex95ja06XHwrWkDcGPDa0C2hzrM6RwVIlXlOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":74332952,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74332952/thumbnails/1.jpg","file_name":"496467.pdf","download_url":"https://www.academia.edu/attachments/74332952/download_file","bulk_download_file_name":"The_Arginase_Pathway_in_Neonatal_Brain_H.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74332952/496467-libre.pdf?1636320609=\u0026response-content-disposition=attachment%3B+filename%3DThe_Arginase_Pathway_in_Neonatal_Brain_H.pdf\u0026Expires=1732410262\u0026Signature=I8MrJhbcqlD1A7uOM~lqNoSyCPXd40FaeMpCqe06nzXP4OEBY5jm2~cYnXW6lVuRQjp4d4ZF8V5WzwvP7b9MwpF0PX1vGoxCZKz2F0AmiRGQgh8MCBdWjN8R-0evfL~dibFFBJARiWYj1SszaYZESHJ1NrnS9vSXONer-CKGWUUlA7kINCGadgvQdamxIeJBG~-oFLWOxYowN5q7lb7N72JXUP0v2vJlpXJe1srUwyDRHjV61O2MITcaJvn5jywURhVgucVttnMBgVqYFZbpjvwOuaeQ00oueQ2lVPcByJiIPYCnnZIfrlJf0~-NHnP9z7-nmN0yJNBzhdYsRZlrTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":8322,"name":"Developmental neuroscience","url":"https://www.academia.edu/Documents/in/Developmental_neuroscience"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":14092825,"url":"https://www.karger.com/Article/Pdf/496467"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229328"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229328/Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia"><img alt="Research paper thumbnail of Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia" class="work-thumbnail" src="https://attachments.academia-assets.com/74333013/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229328/Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia">Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia</a></div><div class="wp-workCard_item"><span>Pediatric research</span><span>, Jan 3, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming. We studied those neonates with a normal/mildly abnormal EEG during the first 24 h of monitoring. A total of 331 neonates were treated with hypothermia and 323 had cEEG recordings available for review; 99 were excluded because of a moderately/severely abnormal cEEG background and/or seizure during the first 24 h of recording, and an additional eight because of early rewarming. The remaining 216 had a normal/mildly abnormal cEEG in the first 24 h. None of these patients subsequently developed seizures. A normal/mildly abnor...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0c35ae8aaa8b51b2d388a3b489a343c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333013,"asset_id":61229328,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333013/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229328"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229328"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229328; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229328]").text(description); $(".js-view-count[data-work-id=61229328]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229328; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229328']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229328, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0c35ae8aaa8b51b2d388a3b489a343c7" } } $('.js-work-strip[data-work-id=61229328]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229328,"title":"Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia","translated_title":"","metadata":{"abstract":"To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming. We studied those neonates with a normal/mildly abnormal EEG during the first 24 h of monitoring. A total of 331 neonates were treated with hypothermia and 323 had cEEG recordings available for review; 99 were excluded because of a moderately/severely abnormal cEEG background and/or seizure during the first 24 h of recording, and an additional eight because of early rewarming. The remaining 216 had a normal/mildly abnormal cEEG in the first 24 h. None of these patients subsequently developed seizures. A normal/mildly abnor...","publication_date":{"day":3,"month":1,"year":2018,"errors":{}},"publication_name":"Pediatric research"},"translated_abstract":"To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming. We studied those neonates with a normal/mildly abnormal EEG during the first 24 h of monitoring. A total of 331 neonates were treated with hypothermia and 323 had cEEG recordings available for review; 99 were excluded because of a moderately/severely abnormal cEEG background and/or seizure during the first 24 h of recording, and an additional eight because of early rewarming. The remaining 216 had a normal/mildly abnormal cEEG in the first 24 h. None of these patients subsequently developed seizures. A normal/mildly abnor...","internal_url":"https://www.academia.edu/61229328/Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia","translated_internal_url":"","created_at":"2021-11-07T13:26:51.794-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333013,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333013/thumbnails/1.jpg","file_name":"s41390-018-0040-x.pdf","download_url":"https://www.academia.edu/attachments/74333013/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Predictive_value_of_early_EEG_for_seizur.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333013/s41390-018-0040-x-libre.pdf?1636320606=\u0026response-content-disposition=attachment%3B+filename%3DPredictive_value_of_early_EEG_for_seizur.pdf\u0026Expires=1732410262\u0026Signature=J-MYMp3KTVXRRMC9gLRX7VQatno~6GGSY7WeeOP17eXscmDm7J~wCooU7P0mXsGBBE~kHSstaMbVYcdV1rZBciRYe3le6A-eMOczAhEZiLTGR~PUh5dgrNEKyfSJCu07sFmx~5bQ-qJ~HKSHGX1v0qUeIO9f2~qqoN~Y~WkztZ5DMeLAaFUmSYIaAlAd6bppxMasRkTmeB1L2faG9vNyHnmOulFVRzwrZSZVln8n5cF9YDoNy5dhlYUrZA5TsixTd7lV77Wr29HTsNNhreh~92afbIcY5smQkjEdk2yYGfiTlzEjWQbwZ0mu2tY1mjOJbYQX1F5rxqN5AD9H7teUKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333013,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333013/thumbnails/1.jpg","file_name":"s41390-018-0040-x.pdf","download_url":"https://www.academia.edu/attachments/74333013/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Predictive_value_of_early_EEG_for_seizur.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333013/s41390-018-0040-x-libre.pdf?1636320606=\u0026response-content-disposition=attachment%3B+filename%3DPredictive_value_of_early_EEG_for_seizur.pdf\u0026Expires=1732410262\u0026Signature=J-MYMp3KTVXRRMC9gLRX7VQatno~6GGSY7WeeOP17eXscmDm7J~wCooU7P0mXsGBBE~kHSstaMbVYcdV1rZBciRYe3le6A-eMOczAhEZiLTGR~PUh5dgrNEKyfSJCu07sFmx~5bQ-qJ~HKSHGX1v0qUeIO9f2~qqoN~Y~WkztZ5DMeLAaFUmSYIaAlAd6bppxMasRkTmeB1L2faG9vNyHnmOulFVRzwrZSZVln8n5cF9YDoNy5dhlYUrZA5TsixTd7lV77Wr29HTsNNhreh~92afbIcY5smQkjEdk2yYGfiTlzEjWQbwZ0mu2tY1mjOJbYQX1F5rxqN5AD9H7teUKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229327"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229327/Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain"><img alt="Research paper thumbnail of Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain" class="work-thumbnail" src="https://attachments.academia-assets.com/74333015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229327/Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain">Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain</a></div><div class="wp-workCard_item"><span>Pediatric research</span><span>, Jan 2, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain choleste...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the impact of hypoxia-ischemia (HI) on brain cholesterol metabolism in the neonatal mice.MethodsPostnatal day 9 C57BL/6 pups were subjected to HI using the Vannucci model. CYP46A1 expression was assessed with western blotting and its cellular localization was determined using immunofluorescence staining. The amount of brain cholesterol, 24S-HC in the cortex and in the serum, was measured with enzyme-linked immunosorbent assay (ELISA).ResultsThere was a transient cholesterol loss at 6 h after HI. CYP46A1 was significantly upregulated at 6 and 24 h following HI with a concomitant increase of 24S-HC in the ipsilateral cortex and in the serum. The serum levels of 24S-HC correlated with those in the brain, a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="224438ec8049aff8ba64772433ed60ca" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333015,"asset_id":61229327,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333015/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229327"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229327"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229327; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229327]").text(description); $(".js-view-count[data-work-id=61229327]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229327; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229327']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229327, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "224438ec8049aff8ba64772433ed60ca" } } $('.js-work-strip[data-work-id=61229327]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229327,"title":"Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain","translated_title":"","metadata":{"abstract":"BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the impact of hypoxia-ischemia (HI) on brain cholesterol metabolism in the neonatal mice.MethodsPostnatal day 9 C57BL/6 pups were subjected to HI using the Vannucci model. CYP46A1 expression was assessed with western blotting and its cellular localization was determined using immunofluorescence staining. The amount of brain cholesterol, 24S-HC in the cortex and in the serum, was measured with enzyme-linked immunosorbent assay (ELISA).ResultsThere was a transient cholesterol loss at 6 h after HI. CYP46A1 was significantly upregulated at 6 and 24 h following HI with a concomitant increase of 24S-HC in the ipsilateral cortex and in the serum. The serum levels of 24S-HC correlated with those in the brain, a...","publication_date":{"day":2,"month":1,"year":2018,"errors":{}},"publication_name":"Pediatric research"},"translated_abstract":"BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the impact of hypoxia-ischemia (HI) on brain cholesterol metabolism in the neonatal mice.MethodsPostnatal day 9 C57BL/6 pups were subjected to HI using the Vannucci model. CYP46A1 expression was assessed with western blotting and its cellular localization was determined using immunofluorescence staining. The amount of brain cholesterol, 24S-HC in the cortex and in the serum, was measured with enzyme-linked immunosorbent assay (ELISA).ResultsThere was a transient cholesterol loss at 6 h after HI. CYP46A1 was significantly upregulated at 6 and 24 h following HI with a concomitant increase of 24S-HC in the ipsilateral cortex and in the serum. The serum levels of 24S-HC correlated with those in the brain, a...","internal_url":"https://www.academia.edu/61229327/Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain","translated_internal_url":"","created_at":"2021-11-07T13:26:51.680-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333015/thumbnails/1.jpg","file_name":"pr201849.pdf","download_url":"https://www.academia.edu/attachments/74333015/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Upregulation_of_cholesterol_24_hydroxyla.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333015/pr201849-libre.pdf?1636320607=\u0026response-content-disposition=attachment%3B+filename%3DUpregulation_of_cholesterol_24_hydroxyla.pdf\u0026Expires=1732410262\u0026Signature=Ow5KFEGJHKLZs~CAf23iQRy-W-0vbjaBJubuzpjz5TQZsPwvkyhuPwi2nWFdMZfeaEUR27qs1FU6-~koVp~SwB07fSqrETlHF9ZL8~Z0-CmeBkiTpKHne8NYzYnioFsnjYMrnRqeOoJ4ZzzzXyfptbAYQ6e3l1AAKTr-4ODaqY~SCgzeSr2O~vrDVOYNyzRbOucpIVwFkIOgEG~9wn5VbzKEfcmoaLBTlpqtQU~2KuL8rGYfIl9Jc44SDUHB~kmhITUEfWNpLbdgsiPAVn-3Wb7DQ-fVdq0HBj2nHJ5WGSa95HiGnsoPd1-JQ2aElo2aYWd-GIrkLi3BN6bonbbURA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333015/thumbnails/1.jpg","file_name":"pr201849.pdf","download_url":"https://www.academia.edu/attachments/74333015/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Upregulation_of_cholesterol_24_hydroxyla.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333015/pr201849-libre.pdf?1636320607=\u0026response-content-disposition=attachment%3B+filename%3DUpregulation_of_cholesterol_24_hydroxyla.pdf\u0026Expires=1732410262\u0026Signature=Ow5KFEGJHKLZs~CAf23iQRy-W-0vbjaBJubuzpjz5TQZsPwvkyhuPwi2nWFdMZfeaEUR27qs1FU6-~koVp~SwB07fSqrETlHF9ZL8~Z0-CmeBkiTpKHne8NYzYnioFsnjYMrnRqeOoJ4ZzzzXyfptbAYQ6e3l1AAKTr-4ODaqY~SCgzeSr2O~vrDVOYNyzRbOucpIVwFkIOgEG~9wn5VbzKEfcmoaLBTlpqtQU~2KuL8rGYfIl9Jc44SDUHB~kmhITUEfWNpLbdgsiPAVn-3Wb7DQ-fVdq0HBj2nHJ5WGSa95HiGnsoPd1-JQ2aElo2aYWd-GIrkLi3BN6bonbbURA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229326"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229326/Dyslipidemia_in_Children_With_Arterial_Ischemic_Stroke_Prevalence_and_Risk_Factors"><img alt="Research paper thumbnail of Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors" class="work-thumbnail" src="https://attachments.academia-assets.com/74333009/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229326/Dyslipidemia_in_Children_With_Arterial_Ischemic_Stroke_Prevalence_and_Risk_Factors">Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors</a></div><div class="wp-workCard_item"><span>Pediatric neurology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Risk factors for pediatric stroke are poorly understood and require study to improve prevention. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non-high-density lipoprotein cholesterol, and hypertriglyceridemia. Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5020d30e65d7912b379b5ae2f31bcd50" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333009,"asset_id":61229326,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333009/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229326"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229326"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229326; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229326]").text(description); $(".js-view-count[data-work-id=61229326]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229326; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229326']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229326, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5020d30e65d7912b379b5ae2f31bcd50" } } $('.js-work-strip[data-work-id=61229326]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229326,"title":"Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors","translated_title":"","metadata":{"abstract":"Risk factors for pediatric stroke are poorly understood and require study to improve prevention. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229325"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229325/Association_of_Histologic_Chorioamnionitis_With_Perinatal_Brain_Injury_and_Early_Childhood_Neurodevelopmental_Outcomes_Among_Preterm_Neonates"><img alt="Research paper thumbnail of Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates" class="work-thumbnail" src="https://attachments.academia-assets.com/74333008/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229325/Association_of_Histologic_Chorioamnionitis_With_Perinatal_Brain_Injury_and_Early_Childhood_Neurodevelopmental_Outcomes_Among_Preterm_Neonates">Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates</a></div><div class="wp-workCard_item"><span>JAMA pediatrics</span><span>, Jan 2, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the patho...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood. Prospective cohort study conducted across 3 academic centers (from April 2006 to September 2013 in Canada, from March 2007 to March 2013 in the Netherlands, and from January 2004 to August 2011 in the United States). Children who were born preterm (24-32 weeks&#39; gestation) and who had undergone a placental pathologic evaluation, magnetic resonance imaging as soon as clinically stable, and Bayley Scales of Infant and Toddler Development, Third Edit...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4200be58139ddbf079435851e2faa4df" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333008,"asset_id":61229325,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333008/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229325"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229325"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229325; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229325]").text(description); $(".js-view-count[data-work-id=61229325]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229325; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229325']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229325, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4200be58139ddbf079435851e2faa4df" } } $('.js-work-strip[data-work-id=61229325]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229325,"title":"Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates","translated_title":"","metadata":{"abstract":"Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. 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Children who were born preterm (24-32 weeks\u0026#39; gestation) and who had undergone a placental pathologic evaluation, magnetic resonance imaging as soon as clinically stable, and Bayley Scales of Infant and Toddler Development, Third Edit...","publication_date":{"day":2,"month":1,"year":2018,"errors":{}},"publication_name":"JAMA pediatrics"},"translated_abstract":"Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood. Prospective cohort study conducted across 3 academic centers (from April 2006 to September 2013 in Canada, from March 2007 to March 2013 in the Netherlands, and from January 2004 to August 2011 in the United States). Children who were born preterm (24-32 weeks\u0026#39; gestation) and who had undergone a placental pathologic evaluation, magnetic resonance imaging as soon as clinically stable, and Bayley Scales of Infant and Toddler Development, Third Edit...","internal_url":"https://www.academia.edu/61229325/Association_of_Histologic_Chorioamnionitis_With_Perinatal_Brain_Injury_and_Early_Childhood_Neurodevelopmental_Outcomes_Among_Preterm_Neonates","translated_internal_url":"","created_at":"2021-11-07T13:26:51.453-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333008,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333008/thumbnails/1.jpg","file_name":"qt4054h9v4.pdf","download_url":"https://www.academia.edu/attachments/74333008/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Association_of_Histologic_Chorioamnionit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333008/qt4054h9v4-libre.pdf?1636320612=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_of_Histologic_Chorioamnionit.pdf\u0026Expires=1732410262\u0026Signature=Tyxo0Z6hUoSdMoTaxSaNsNygLmoAYT4g0yDaWNVgdu2t1sEdshDDSwZd1vZ9laensOV49bHuw57QqZzRGYuQaJBJub2dRKHMD2rdDaDfACCpU~jI0Lz8k1nr56LFVf3l~kAa9umE8QviQ2xBaLU50dAj2Y-lV1T9Juj6ZWLs4L83w3yBc3GMFgIOcWBc~4rfu5v0cKkGqQfcF6IqR7CxdXjQrFIPJbN68DUVPOu8OGtgswg9PUossJ65m1814npKtJ2qB4pfGBKmVV8yic~YDEfpRSzSjipOl0sMbwrtWSI3wdrGGLbiSo00iQhhwH7IE4cCzakAUairPr4p8267iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Association_of_Histologic_Chorioamnionitis_With_Perinatal_Brain_Injury_and_Early_Childhood_Neurodevelopmental_Outcomes_Among_Preterm_Neonates","translated_slug":"","page_count":27,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333008,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333008/thumbnails/1.jpg","file_name":"qt4054h9v4.pdf","download_url":"https://www.academia.edu/attachments/74333008/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Association_of_Histologic_Chorioamnionit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333008/qt4054h9v4-libre.pdf?1636320612=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_of_Histologic_Chorioamnionit.pdf\u0026Expires=1732410262\u0026Signature=Tyxo0Z6hUoSdMoTaxSaNsNygLmoAYT4g0yDaWNVgdu2t1sEdshDDSwZd1vZ9laensOV49bHuw57QqZzRGYuQaJBJub2dRKHMD2rdDaDfACCpU~jI0Lz8k1nr56LFVf3l~kAa9umE8QviQ2xBaLU50dAj2Y-lV1T9Juj6ZWLs4L83w3yBc3GMFgIOcWBc~4rfu5v0cKkGqQfcF6IqR7CxdXjQrFIPJbN68DUVPOu8OGtgswg9PUossJ65m1814npKtJ2qB4pfGBKmVV8yic~YDEfpRSzSjipOl0sMbwrtWSI3wdrGGLbiSo00iQhhwH7IE4cCzakAUairPr4p8267iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229324"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229324/Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats"><img alt="Research paper thumbnail of Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229324/Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats">Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats</a></div><div class="wp-workCard_item"><span>Journal of Neuroscience Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including stroke and neonatal ischemic brain injury. Delayed intranasal administration of mesenchymal stem cells (MSCs) after experimental hypoxia-ischemia and after a transient middle cerebral artery occlusion (tMCAO) in neonatal rats has shown improvement in long-term functional outcomes, but the effects of MSCs on white matter injury (WMI) are insufficiently understood. In this study we used longitudinal T2-weighted (T2W) and diffusion tensor magnetic resonance imaging (MRI) to characterize chronic injury after tMCAO induced in postnatal day 10 (P10) rats and examined the effects of delayed MSC administration on WMI, axonal coverage, and long-term somatosensory function. We show unilateral injury- and region-dependent changes in diffusion fraction anisotropy 1 and 2 weeks after tMCAO that correspond to accumulation of degraded myelin basic protein, astrocytosis, and decreased axonal coverage. With the use of stringent T2W-based injury criteria at 72 hr after tMCAO to randomize neonatal rats to receive intranasal MSCs or vehicle, we show that a single MSC administration attenuates WMI and enhances somatosensory function 28 days after stroke. A positive correlation was found between MSC-enhanced white matter integrity and functional performance in injured neonatal rats. Collectively, these data indicate that the damage induced by tMCAO progresses over time and is halted by administration of MSCs. © 2016 Wiley Periodicals, Inc.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229324"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229324"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229324; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229324]").text(description); $(".js-view-count[data-work-id=61229324]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229324; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229324']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229324, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=61229324]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229324,"title":"Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats","translated_title":"","metadata":{"abstract":"Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including stroke and neonatal ischemic brain injury. Delayed intranasal administration of mesenchymal stem cells (MSCs) after experimental hypoxia-ischemia and after a transient middle cerebral artery occlusion (tMCAO) in neonatal rats has shown improvement in long-term functional outcomes, but the effects of MSCs on white matter injury (WMI) are insufficiently understood. In this study we used longitudinal T2-weighted (T2W) and diffusion tensor magnetic resonance imaging (MRI) to characterize chronic injury after tMCAO induced in postnatal day 10 (P10) rats and examined the effects of delayed MSC administration on WMI, axonal coverage, and long-term somatosensory function. We show unilateral injury- and region-dependent changes in diffusion fraction anisotropy 1 and 2 weeks after tMCAO that correspond to accumulation of degraded myelin basic protein, astrocytosis, and decreased axonal coverage. With the use of stringent T2W-based injury criteria at 72 hr after tMCAO to randomize neonatal rats to receive intranasal MSCs or vehicle, we show that a single MSC administration attenuates WMI and enhances somatosensory function 28 days after stroke. A positive correlation was found between MSC-enhanced white matter integrity and functional performance in injured neonatal rats. Collectively, these data indicate that the damage induced by tMCAO progresses over time and is halted by administration of MSCs. © 2016 Wiley Periodicals, Inc.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Journal of Neuroscience Research"},"translated_abstract":"Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including stroke and neonatal ischemic brain injury. Delayed intranasal administration of mesenchymal stem cells (MSCs) after experimental hypoxia-ischemia and after a transient middle cerebral artery occlusion (tMCAO) in neonatal rats has shown improvement in long-term functional outcomes, but the effects of MSCs on white matter injury (WMI) are insufficiently understood. In this study we used longitudinal T2-weighted (T2W) and diffusion tensor magnetic resonance imaging (MRI) to characterize chronic injury after tMCAO induced in postnatal day 10 (P10) rats and examined the effects of delayed MSC administration on WMI, axonal coverage, and long-term somatosensory function. We show unilateral injury- and region-dependent changes in diffusion fraction anisotropy 1 and 2 weeks after tMCAO that correspond to accumulation of degraded myelin basic protein, astrocytosis, and decreased axonal coverage. With the use of stringent T2W-based injury criteria at 72 hr after tMCAO to randomize neonatal rats to receive intranasal MSCs or vehicle, we show that a single MSC administration attenuates WMI and enhances somatosensory function 28 days after stroke. A positive correlation was found between MSC-enhanced white matter integrity and functional performance in injured neonatal rats. Collectively, these data indicate that the damage induced by tMCAO progresses over time and is halted by administration of MSCs. © 2016 Wiley Periodicals, Inc.","internal_url":"https://www.academia.edu/61229324/Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats","translated_internal_url":"","created_at":"2021-11-07T13:26:51.341-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229323"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229323/Antenatal_Exposure_to_Magnesium_Sulfate_Is_Associated_with_Reduced_Cerebellar_Hemorrhage_in_Preterm_Newborns"><img alt="Research paper thumbnail of Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns" class="work-thumbnail" src="https://attachments.academia-assets.com/74333010/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229323/Antenatal_Exposure_to_Magnesium_Sulfate_Is_Associated_with_Reduced_Cerebellar_Hemorrhage_in_Preterm_Newborns">Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns</a></div><div class="wp-workCard_item"><span>The Journal of pediatrics</span><span>, Jan 22, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To determine the association of antenatal magnesium sulfate with cerebellar hemorrhage in a prosp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To determine the association of antenatal magnesium sulfate with cerebellar hemorrhage in a prospective cohort of premature newborns evaluated by magnetic resonance imaging (MRI). Cross-sectional analysis of baseline characteristics from a prospective cohort of preterm newborns (&lt;33 weeks gestation) evaluated with 3T-MRI shortly after birth. Exclusion criteria were clinical evidence of a congenital syndrome, congenital infection, or clinical status too unstable for transport to MRI. Antenatal magnesium sulfate exposure was abstracted from the medical records and the indication was classified as obstetric or neuroprotection. Two pediatric neuroradiologists, blinded to the clinical history, scored axial T2-weighted and iron susceptibility MRI sequences for cerebellar hemorrhage. The association of antenatal magnesium sulfate with cerebellar hemorrhage was evaluated using multivariable logistic regression, adjusting for postmenstrual age at MRI and known predictors of cerebellar hem...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="84bf176b95e45fe21a8ece0d776d667c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333010,"asset_id":61229323,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333010/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229323"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229323"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229323; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229323]").text(description); $(".js-view-count[data-work-id=61229323]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229323; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229323']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229323, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "84bf176b95e45fe21a8ece0d776d667c" } } $('.js-work-strip[data-work-id=61229323]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229323,"title":"Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns","translated_title":"","metadata":{"abstract":"To determine the association of antenatal magnesium sulfate with cerebellar hemorrhage in a prospective cohort of premature newborns evaluated by magnetic resonance imaging (MRI). Cross-sectional analysis of baseline characteristics from a prospective cohort of preterm newborns (\u0026lt;33 weeks gestation) evaluated with 3T-MRI shortly after birth. Exclusion criteria were clinical evidence of a congenital syndrome, congenital infection, or clinical status too unstable for transport to MRI. Antenatal magnesium sulfate exposure was abstracted from the medical records and the indication was classified as obstetric or neuroprotection. Two pediatric neuroradiologists, blinded to the clinical history, scored axial T2-weighted and iron susceptibility MRI sequences for cerebellar hemorrhage. The association of antenatal magnesium sulfate with cerebellar hemorrhage was evaluated using multivariable logistic regression, adjusting for postmenstrual age at MRI and known predictors of cerebellar hem...","publication_date":{"day":22,"month":1,"year":2016,"errors":{}},"publication_name":"The Journal of pediatrics"},"translated_abstract":"To determine the association of antenatal magnesium sulfate with cerebellar hemorrhage in a prospective cohort of premature newborns evaluated by magnetic resonance imaging (MRI). Cross-sectional analysis of baseline characteristics from a prospective cohort of preterm newborns (\u0026lt;33 weeks gestation) evaluated with 3T-MRI shortly after birth. Exclusion criteria were clinical evidence of a congenital syndrome, congenital infection, or clinical status too unstable for transport to MRI. Antenatal magnesium sulfate exposure was abstracted from the medical records and the indication was classified as obstetric or neuroprotection. Two pediatric neuroradiologists, blinded to the clinical history, scored axial T2-weighted and iron susceptibility MRI sequences for cerebellar hemorrhage. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229321"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229321/Neutrophil_protein_kinase_Cd_as_a_mediator_of_stroke_reperfusion_injury"><img alt="Research paper thumbnail of Neutrophil protein kinase Cd as a mediator of stroke-reperfusion injury" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229321/Neutrophil_protein_kinase_Cd_as_a_mediator_of_stroke_reperfusion_injury">Neutrophil protein kinase Cd as a mediator of stroke-reperfusion injury</a></div><div class="wp-workCard_item"><span>J Clin Invest</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229321"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229321"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229321; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229320"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229320/Delayed_erythropoietin_therapy_improves_histological_and_behavioral_outcomes_after_transient_neonatal_stroke"><img alt="Research paper thumbnail of Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229320/Delayed_erythropoietin_therapy_improves_histological_and_behavioral_outcomes_after_transient_neonatal_stroke">Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke</a></div><div class="wp-workCard_item"><span>Neurobiology of disease</span><span>, Sep 30, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Stroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Stroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted therapeutic options. The purpose of this study is to investigate the efficacy of delayed initiation of multiple dose erythropoietin (EPO) therapy in improving histological and behavioral outcomes after early transient ischemic stroke. 32 postnatal day 10 (P10) Sprague-Dawley rats underwent sham surgery or transient middle cerebral artery occlusion (tMCAO) for 3h, resulting in injury involving the striatum and parieto-temporal cortex. EPO (1000U/kg per dose×3 doses) or vehicle was administered intraperitoneally starting one week after tMCAO (at P17, P20, and P23). At four weeks after tMCAO, sensorimotor function was assessed in these four groups (6 vehicle-sham, 6 EPO-sham, 10 vehicle-tMCAO and 10 EPO-tMCAO) with forepaw preference in cylinder rearing trials. Brains were then harvested for hemispheric volume and Western blot analysis. 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EPO-tMCAO animals had significant improvement in forep...","publication_date":{"day":30,"month":9,"year":2016,"errors":{}},"publication_name":"Neurobiology of disease"},"translated_abstract":"Stroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted therapeutic options. The purpose of this study is to investigate the efficacy of delayed initiation of multiple dose erythropoietin (EPO) therapy in improving histological and behavioral outcomes after early transient ischemic stroke. 32 postnatal day 10 (P10) Sprague-Dawley rats underwent sham surgery or transient middle cerebral artery occlusion (tMCAO) for 3h, resulting in injury involving the striatum and parieto-temporal cortex. EPO (1000U/kg per dose×3 doses) or vehicle was administered intraperitoneally starting one week after tMCAO (at P17, P20, and P23). At four weeks after tMCAO, sensorimotor function was assessed in these four groups (6 vehicle-sham, 6 EPO-sham, 10 vehicle-tMCAO and 10 EPO-tMCAO) with forepaw preference in cylinder rearing trials. Brains were then harvested for hemispheric volume and Western blot analysis. EPO-tMCAO animals had significant improvement in forep...","internal_url":"https://www.academia.edu/61229320/Delayed_erythropoietin_therapy_improves_histological_and_behavioral_outcomes_after_transient_neonatal_stroke","translated_internal_url":"","created_at":"2021-11-07T13:26:50.822-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Delayed_erythropoietin_therapy_improves_histological_and_behavioral_outcomes_after_transient_neonatal_stroke","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[],"research_interests":[{"id":2214,"name":"Neurobiology Of Disease","url":"https://www.academia.edu/Documents/in/Neurobiology_Of_Disease"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":61234,"name":"Stroke","url":"https://www.academia.edu/Documents/in/Stroke"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2450733,"name":"Brain injuries","url":"https://www.academia.edu/Documents/in/Brain_injuries"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229319"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229319/Alteration_in_Downstream_Hypoxia_Gene_Signaling_in_Neonatal_Glutathione_Peroxidase_Overexpressing_Mouse_Brain_after_Hypoxia_Ischemia"><img alt="Research paper thumbnail of Alteration in Downstream Hypoxia Gene Signaling in Neonatal Glutathione Peroxidase Overexpressing Mouse Brain after Hypoxia-Ischemia" class="work-thumbnail" src="https://attachments.academia-assets.com/74333074/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229319/Alteration_in_Downstream_Hypoxia_Gene_Signaling_in_Neonatal_Glutathione_Peroxidase_Overexpressing_Mouse_Brain_after_Hypoxia_Ischemia">Alteration in Downstream Hypoxia Gene Signaling in Neonatal Glutathione Peroxidase Overexpressing Mouse Brain after Hypoxia-Ischemia</a></div><div class="wp-workCard_item"><span>Developmental neuroscience</span><span>, Jan 17, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously shown that glutathione peroxidase (GPx) overexpressing mice (hGPx-tg) have red...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously shown that glutathione peroxidase (GPx) overexpressing mice (hGPx-tg) have reduced brain injury after neonatal hypoxia-ischemia (HI) as a consequence of reduced hydrogen peroxide accumulation. However, this protection is reversed with hypoxia preconditioning, raising the question of the roles of the genes regulated by hypoxia-inducible factor-1α (HIF-1α) and their transcription products, such as erythropoietin (EPO), in both the initial protection and subsequent reversal of protection. hGPx-tg and their wild-type (WT) littermates underwent the Vannucci procedure of HI brain injury at postnatal day 9 - left carotid artery ligation followed by exposure to 10% oxygen for 50 min. Brain cortices and hippocampi were subsequently collected 0.5, 4 and 24 h later for the determination of protein expression by Western blot for GPx, HIF-1α, HIF-2α, EPO, EPO receptor, ERK1/2, phospho-ERK1/2, spectrin 145/150 (as a marker of calpain-specific necrotic cell death), and spectrin ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="af92d7318ad6c1d855a06a611c9b492e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333074,"asset_id":61229319,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333074/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229319"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229319"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229319; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229319]").text(description); $(".js-view-count[data-work-id=61229319]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229319; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229319']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229319, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "af92d7318ad6c1d855a06a611c9b492e" } } $('.js-work-strip[data-work-id=61229319]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229319,"title":"Alteration in Downstream Hypoxia Gene Signaling in Neonatal Glutathione Peroxidase Overexpressing Mouse Brain after Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"We have previously shown that glutathione peroxidase (GPx) overexpressing mice (hGPx-tg) have reduced brain injury after neonatal hypoxia-ischemia (HI) as a consequence of reduced hydrogen peroxide accumulation. However, this protection is reversed with hypoxia preconditioning, raising the question of the roles of the genes regulated by hypoxia-inducible factor-1α (HIF-1α) and their transcription products, such as erythropoietin (EPO), in both the initial protection and subsequent reversal of protection. hGPx-tg and their wild-type (WT) littermates underwent the Vannucci procedure of HI brain injury at postnatal day 9 - left carotid artery ligation followed by exposure to 10% oxygen for 50 min. Brain cortices and hippocampi were subsequently collected 0.5, 4 and 24 h later for the determination of protein expression by Western blot for GPx, HIF-1α, HIF-2α, EPO, EPO receptor, ERK1/2, phospho-ERK1/2, spectrin 145/150 (as a marker of calpain-specific necrotic cell death), and spectrin ...","publication_date":{"day":17,"month":1,"year":2015,"errors":{}},"publication_name":"Developmental neuroscience"},"translated_abstract":"We have previously shown that glutathione peroxidase (GPx) overexpressing mice (hGPx-tg) have reduced brain injury after neonatal hypoxia-ischemia (HI) as a consequence of reduced hydrogen peroxide accumulation. However, this protection is reversed with hypoxia preconditioning, raising the question of the roles of the genes regulated by hypoxia-inducible factor-1α (HIF-1α) and their transcription products, such as erythropoietin (EPO), in both the initial protection and subsequent reversal of protection. hGPx-tg and their wild-type (WT) littermates underwent the Vannucci procedure of HI brain injury at postnatal day 9 - left carotid artery ligation followed by exposure to 10% oxygen for 50 min. Brain cortices and hippocampi were subsequently collected 0.5, 4 and 24 h later for the determination of protein expression by Western blot for GPx, HIF-1α, HIF-2α, EPO, EPO receptor, ERK1/2, phospho-ERK1/2, spectrin 145/150 (as a marker of calpain-specific necrotic cell death), and spectrin ...","internal_url":"https://www.academia.edu/61229319/Alteration_in_Downstream_Hypoxia_Gene_Signaling_in_Neonatal_Glutathione_Peroxidase_Overexpressing_Mouse_Brain_after_Hypoxia_Ischemia","translated_internal_url":"","created_at":"2021-11-07T13:26:50.707-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333074,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333074/thumbnails/1.jpg","file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf","download_url":"https://www.academia.edu/attachments/74333074/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333074/Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf?1636320498=\u0026response-content-disposition=attachment%3B+filename%3DAlteration_in_Downstream_Hypoxia_Gene_Si.pdf\u0026Expires=1732410262\u0026Signature=T5aHUnkPQfUSKIIEFog8VOjCqZNZdlsTNFa9-wQ3xsw1Pw8BnG20TyosZj-5d1Foq92ejLFqRmd~~43diRIyzNXzOI2vjAF04wRlir1eRES-N899G-D~o-BHPv1nZPgceesR0pJCEtcY~Saa~E9WXRWk0Mpfg3ldbRqBJBZbZDeht-Khe3AgLLJUeoJAuW24mbdU-3eyRv~u6zlWS3RS27r0zH4fCu3PAhshXUBN-xLe1ngT-3AhhO7plwMvdfvR8dBckT9wxz4fBIjAfIMypWHsgyhP3TQNJa2mBTb4RY0I0bgM8QCWlntmwRsfJQj0M0dWEDONMb0GVHllTYidtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Alteration_in_Downstream_Hypoxia_Gene_Signaling_in_Neonatal_Glutathione_Peroxidase_Overexpressing_Mouse_Brain_after_Hypoxia_Ischemia","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333074,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333074/thumbnails/1.jpg","file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf","download_url":"https://www.academia.edu/attachments/74333074/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333074/Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf?1636320498=\u0026response-content-disposition=attachment%3B+filename%3DAlteration_in_Downstream_Hypoxia_Gene_Si.pdf\u0026Expires=1732410262\u0026Signature=T5aHUnkPQfUSKIIEFog8VOjCqZNZdlsTNFa9-wQ3xsw1Pw8BnG20TyosZj-5d1Foq92ejLFqRmd~~43diRIyzNXzOI2vjAF04wRlir1eRES-N899G-D~o-BHPv1nZPgceesR0pJCEtcY~Saa~E9WXRWk0Mpfg3ldbRqBJBZbZDeht-Khe3AgLLJUeoJAuW24mbdU-3eyRv~u6zlWS3RS27r0zH4fCu3PAhshXUBN-xLe1ngT-3AhhO7plwMvdfvR8dBckT9wxz4fBIjAfIMypWHsgyhP3TQNJa2mBTb4RY0I0bgM8QCWlntmwRsfJQj0M0dWEDONMb0GVHllTYidtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":8322,"name":"Developmental neuroscience","url":"https://www.academia.edu/Documents/in/Developmental_neuroscience"},{"id":37931,"name":"Transgenic Mice","url":"https://www.academia.edu/Documents/in/Transgenic_Mice"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":141395,"name":"Glutathione Peroxidase","url":"https://www.academia.edu/Documents/in/Glutathione_Peroxidase"},{"id":177250,"name":"ERK","url":"https://www.academia.edu/Documents/in/ERK"},{"id":213910,"name":"Mitogen Activated Protein Kinase","url":"https://www.academia.edu/Documents/in/Mitogen_Activated_Protein_Kinase"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2754174,"name":"Hypoxia inducible factor","url":"https://www.academia.edu/Documents/in/Hypoxia_inducible_factor"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229317"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229317/Patterns_and_implications_of_MR_contrast_enhancement_in_perinatal_asphyxia_a_preliminary_report"><img alt="Research paper thumbnail of Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report" class="work-thumbnail" src="https://attachments.academia-assets.com/74333067/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229317/Patterns_and_implications_of_MR_contrast_enhancement_in_perinatal_asphyxia_a_preliminary_report">Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report</a></div><div class="wp-workCard_item"><span>AJNR. American journal of neuroradiology</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To determine the presence and location of MR contrast enhancement in infants with perinatal asphy...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To determine the presence and location of MR contrast enhancement in infants with perinatal asphyxia and to evaluate the utility of enhancement in assessing extent of brain damage. Precontrast and postcontrast MR examinations within the first 10 days of life were evaluated in 10 infants with suspected hypoxic-ischemic birth injury. Findings were correlated with clinical birth history and short-term neurologic follow-up. All four infants with MR signal abnormalities and contrast enhancement in the basal ganglia and brain stem had early seizures and profound neurologic deficits at early follow-up. Two infants had abnormal scans but no contrast enhancement; one with MR signal abnormality within the basal ganglia is neurologically healthy at 10-month follow-up, whereas the other, in status epilepticus at the time of imaging at age 2 days, died. Two infants with minimal parasagittal subcortical white matter enhancement had no early seizure activity and only mild developmental delay at ea...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="359d69f21e808610a22f54f55dda6a40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333067,"asset_id":61229317,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333067/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229317"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229317"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229317; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229317]").text(description); $(".js-view-count[data-work-id=61229317]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229317; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229317']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229317, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "359d69f21e808610a22f54f55dda6a40" } } $('.js-work-strip[data-work-id=61229317]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229317,"title":"Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report","translated_title":"","metadata":{"abstract":"To determine the presence and location of MR contrast enhancement in infants with perinatal asphyxia and to evaluate the utility of enhancement in assessing extent of brain damage. Precontrast and postcontrast MR examinations within the first 10 days of life were evaluated in 10 infants with suspected hypoxic-ischemic birth injury. Findings were correlated with clinical birth history and short-term neurologic follow-up. All four infants with MR signal abnormalities and contrast enhancement in the basal ganglia and brain stem had early seizures and profound neurologic deficits at early follow-up. Two infants had abnormal scans but no contrast enhancement; one with MR signal abnormality within the basal ganglia is neurologically healthy at 10-month follow-up, whereas the other, in status epilepticus at the time of imaging at age 2 days, died. Two infants with minimal parasagittal subcortical white matter enhancement had no early seizure activity and only mild developmental delay at ea...","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"AJNR. American journal of neuroradiology"},"translated_abstract":"To determine the presence and location of MR contrast enhancement in infants with perinatal asphyxia and to evaluate the utility of enhancement in assessing extent of brain damage. Precontrast and postcontrast MR examinations within the first 10 days of life were evaluated in 10 infants with suspected hypoxic-ischemic birth injury. Findings were correlated with clinical birth history and short-term neurologic follow-up. All four infants with MR signal abnormalities and contrast enhancement in the basal ganglia and brain stem had early seizures and profound neurologic deficits at early follow-up. Two infants had abnormal scans but no contrast enhancement; one with MR signal abnormality within the basal ganglia is neurologically healthy at 10-month follow-up, whereas the other, in status epilepticus at the time of imaging at age 2 days, died. Two infants with minimal parasagittal subcortical white matter enhancement had no early seizure activity and only mild developmental delay at 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Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":119259,"name":"Magnetic Resonance","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":258680,"name":"Cardiopulmonary Resuscitation","url":"https://www.academia.edu/Documents/in/Cardiopulmonary_Resuscitation"},{"id":386290,"name":"Gadolinium","url":"https://www.academia.edu/Documents/in/Gadolinium"},{"id":484219,"name":"Basal ganglia","url":"https://www.academia.edu/Documents/in/Basal_ganglia"},{"id":797418,"name":"Gestational Age","url":"https://www.academia.edu/Documents/in/Gestational_Age"},{"id":879600,"name":"Developmental delay","url":"https://www.academia.edu/Documents/in/Developmental_delay"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1279814,"name":"Heterocyclic compounds","url":"https://www.academia.edu/Documents/in/Heterocyclic_compounds"},{"id":1407305,"name":"Contrast Media","url":"https://www.academia.edu/Documents/in/Contrast_Media"},{"id":1431361,"name":"Brain Damage","url":"https://www.academia.edu/Documents/in/Brain_Damage"},{"id":1554834,"name":"Asphyxia neonatorum","url":"https://www.academia.edu/Documents/in/Asphyxia_neonatorum"},{"id":2426000,"name":"Brain stem","url":"https://www.academia.edu/Documents/in/Brain_stem"},{"id":2463663,"name":"Neurologic Examination","url":"https://www.academia.edu/Documents/in/Neurologic_Examination"},{"id":3544613,"name":"Heart arrest","url":"https://www.academia.edu/Documents/in/Heart_arrest"},{"id":3842849,"name":"Meconium Aspiration Syndrome","url":"https://www.academia.edu/Documents/in/Meconium_Aspiration_Syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229316"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229316/Nucleated_red_blood_cell_counts_not_associated_with_brain_injury_or_outcome"><img alt="Research paper thumbnail of Nucleated red blood cell counts: not associated with brain injury or outcome" class="work-thumbnail" src="https://attachments.academia-assets.com/74333088/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229316/Nucleated_red_blood_cell_counts_not_associated_with_brain_injury_or_outcome">Nucleated red blood cell counts: not associated with brain injury or outcome</a></div><div class="wp-workCard_item"><span>Pediatric neurology</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective was to determine whether an elevated nucleated red blood cell count at birth after ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective was to determine whether an elevated nucleated red blood cell count at birth after perinatal depression is associated with brain injury as measured by (1) proton magnetic resonance spectroscopy and (2) abnormal neurodevelopmental outcome at 30 months of age. The nucleated red blood cell counts from the first 24 hours of life were statistically analyzed in 33 term infants enrolled in a prospective study of the value of magnetic resonance imaging for the determination of neurodevelopmental outcome after perinatal depression. Nucleated red blood cell counts were elevated in 13/33 (39%). Abnormal outcome (19/33, 54%) was associated with Score for Neonatal Acute Physiology-Perinatal Extension (P = 0.04), decreased N-acetylaspartate to choline ratio in the basal ganglia (P = 0.009), and increased lactate to choline ratio in the basal ganglia (P = 0.02), but not with cord pH, Apgar score, or nucleated red blood cell value. In a logistic regression model, increasing nucleated ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb21518c78963f8d35abf107d80a576d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333088,"asset_id":61229316,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333088/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229316"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229316"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229316; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229316]").text(description); $(".js-view-count[data-work-id=61229316]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229316; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229316']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229316, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb21518c78963f8d35abf107d80a576d" } } $('.js-work-strip[data-work-id=61229316]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229316,"title":"Nucleated red blood cell counts: not associated with brain injury or outcome","translated_title":"","metadata":{"abstract":"The objective was to determine whether an elevated nucleated red blood cell count at birth after perinatal depression is associated with brain injury as measured by (1) proton magnetic resonance spectroscopy and (2) abnormal neurodevelopmental outcome at 30 months of age. The nucleated red blood cell counts from the first 24 hours of life were statistically analyzed in 33 term infants enrolled in a prospective study of the value of magnetic resonance imaging for the determination of neurodevelopmental outcome after perinatal depression. Nucleated red blood cell counts were elevated in 13/33 (39%). Abnormal outcome (19/33, 54%) was associated with Score for Neonatal Acute Physiology-Perinatal Extension (P = 0.04), decreased N-acetylaspartate to choline ratio in the basal ganglia (P = 0.009), and increased lactate to choline ratio in the basal ganglia (P = 0.02), but not with cord pH, Apgar score, or nucleated red blood cell value. In a logistic regression model, increasing nucleated ...","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Pediatric neurology"},"translated_abstract":"The objective was to determine whether an elevated nucleated red blood cell count at birth after perinatal depression is associated with brain injury as measured by (1) proton magnetic resonance spectroscopy and (2) abnormal neurodevelopmental outcome at 30 months of age. The nucleated red blood cell counts from the first 24 hours of life were statistically analyzed in 33 term infants enrolled in a prospective study of the value of magnetic resonance imaging for the determination of neurodevelopmental outcome after perinatal depression. Nucleated red blood cell counts were elevated in 13/33 (39%). Abnormal outcome (19/33, 54%) was associated with Score for Neonatal Acute Physiology-Perinatal Extension (P = 0.04), decreased N-acetylaspartate to choline ratio in the basal ganglia (P = 0.009), and increased lactate to choline ratio in the basal ganglia (P = 0.02), but not with cord pH, Apgar score, or nucleated red blood cell value. In a logistic regression model, increasing nucleated ...","internal_url":"https://www.academia.edu/61229316/Nucleated_red_blood_cell_counts_not_associated_with_brain_injury_or_outcome","translated_internal_url":"","created_at":"2021-11-07T13:26:50.507-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333088,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333088/thumbnails/1.jpg","file_name":"s0887-8994_2803_2900266-220211107-2191-1rsgigx.pdf","download_url":"https://www.academia.edu/attachments/74333088/download_file?st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Nucleated_red_blood_cell_counts_not_asso.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333088/s0887-8994_2803_2900266-220211107-2191-1rsgigx-libre.pdf?1636320603=\u0026response-content-disposition=attachment%3B+filename%3DNucleated_red_blood_cell_counts_not_asso.pdf\u0026Expires=1732410262\u0026Signature=eOmRIj2IBdUk15Yoy4GKbnbun5Fq6BzWnI~UHS7trSPhssKH1zywVlSPrmJvuO6-~f7SeAhcqZIrgXNWSDbL-Tlska9twHI1ge5qj1TTnIwrvJDtKFW5KrLLnowPNoLhcbF4iC1kACRQ94byQ5Rf0tRx5mKW~onQAWL4W4I5CleL42jjlsv8QdyOJYL4ikHGqLR14KuTCd-ruX90xp9YeoJfuP4ZTRN05D3~-EdI-EoStHsiV2qdE1ri3AWVJVRVCshsiyzgdaA81nEq3c21~f9P03IK77KhaEFkJJ~ryWmKRINDMbdgny4NPAkIA8fdY-vpTVgDtAH3vhkckdKccg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Nucleated_red_blood_cell_counts_not_associated_with_brain_injury_or_outcome","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna 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Model","url":"https://www.academia.edu/Documents/in/Logistic_Regression_Model"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models"},{"id":1312754,"name":"Prospective Study","url":"https://www.academia.edu/Documents/in/Prospective_Study"},{"id":2177050,"name":"Perinatal Care","url":"https://www.academia.edu/Documents/in/Perinatal_Care"},{"id":2439414,"name":"Magnetic resonance image","url":"https://www.academia.edu/Documents/in/Magnetic_resonance_image"},{"id":2450733,"name":"Brain injuries","url":"https://www.academia.edu/Documents/in/Brain_injuries"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"},{"id":3080132,"name":"Erythrocyte Count","url":"https://www.academia.edu/Documents/in/Erythrocyte_Count"},{"id":3760355,"name":"erythroblasts","url":"https://www.academia.edu/Documents/in/erythroblasts"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229315"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229315/NR2B_Phosphorylation_at_Tyrosine_1472_Contributes_to_Brain_Injury_in_a_Rodent_Model_of_Neonatal_Hypoxia_Ischemia"><img alt="Research paper thumbnail of NR2B Phosphorylation at Tyrosine 1472 Contributes to Brain Injury in a Rodent Model of Neonatal Hypoxia-Ischemia" class="work-thumbnail" src="https://attachments.academia-assets.com/74333023/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229315/NR2B_Phosphorylation_at_Tyrosine_1472_Contributes_to_Brain_Injury_in_a_Rodent_Model_of_Neonatal_Hypoxia_Ischemia">NR2B Phosphorylation at Tyrosine 1472 Contributes to Brain Injury in a Rodent Model of Neonatal Hypoxia-Ischemia</a></div><div class="wp-workCard_item"><span>Stroke</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphory...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. Although Y1472 phosphorylation is important for synaptic plasticity, it is unknown whether it is involved in NMDA receptor–mediated excitotoxicity in neonatal brain hypoxia-ischemia (HI). This study was designed to elucidate the specific role of Y1472 phosphorylation of NR2B in neonatal HI in vivo and in NMDA-mediated neuronal death in vitro. Methods— Neonatal mice with a knockin mutation of Y1472 to phenylalanine (YF-KI) and their wild-type littermates were subjected to HI using the Vannucci model. Brains were scored 5 days later for damage using cresyl violet and iron staining. Western blotting and immunoprecipitation were performed to determine NR2B tyrosine phosphorylation. Expression of NADPH oxidase subunits and superoxide production were measured in vivo. NMDA-induced calcium res...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c53a3754a82448aefd5d9ca469644861" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333023,"asset_id":61229315,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333023/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229315"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229315"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229315; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229315]").text(description); $(".js-view-count[data-work-id=61229315]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229315; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229315']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229315, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c53a3754a82448aefd5d9ca469644861" } } $('.js-work-strip[data-work-id=61229315]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229315,"title":"NR2B Phosphorylation at Tyrosine 1472 Contributes to Brain Injury in a Rodent Model of Neonatal Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. 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NMDA-induced calcium res...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Stroke"},"translated_abstract":"Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. Although Y1472 phosphorylation is important for synaptic plasticity, it is unknown whether it is involved in NMDA receptor–mediated excitotoxicity in neonatal brain hypoxia-ischemia (HI). This study was designed to elucidate the specific role of Y1472 phosphorylation of NR2B in neonatal HI in vivo and in NMDA-mediated neuronal death in vitro. Methods— Neonatal mice with a knockin mutation of Y1472 to phenylalanine (YF-KI) and their wild-type littermates were subjected to HI using the Vannucci model. Brains were scored 5 days later for damage using cresyl violet and iron staining. Western blotting and immunoprecipitation were performed to determine NR2B tyrosine phosphorylation. Expression of NADPH oxidase subunits and superoxide production were measured in vivo. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3203679" id="papers"><div class="js-work-strip profile--work_container" data-work-id="125338049"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125338049/A_Metabolomics_Study_of_Hypoxia_Ischemia_during_Mouse_Brain_Development_Using_Hyperpolarized_13C"><img alt="Research paper thumbnail of A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C" class="work-thumbnail" src="https://attachments.academia-assets.com/119400358/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125338049/A_Metabolomics_Study_of_Hypoxia_Ischemia_during_Mouse_Brain_Development_Using_Hyperpolarized_13C">A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C</a></div><div class="wp-workCard_item"><span>Developmental Neuroscience</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism. Methods: Mice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31. We used hyperpolarized 13C MRS to investigate the metabolic exchange of pyruvate to lactate in real time during brain development following HI. 13C-1-labeled pyruvate was hyperpolarized and injected into the tail vein through a tail-vein catheter. Chemical-shift imaging was performed to acquire spectral-spatial information of the metabolites in the brain. A voxel placed on each of the injured and contralateral hemispheres was chosen for comparison. The difference in pyruvate delivery and lactate to pyruvate ratio was calculated for each of the voxels at each time point. The normalized lactate level of the injured hemisphere was also calculated for each mouse at each ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="791f4c7abd6fa59f35dc7ade0d09dfe9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119400358,"asset_id":125338049,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/119400358/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125338049"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125338049"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125338049; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125338049]").text(description); $(".js-view-count[data-work-id=125338049]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125338049; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125338049']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125338049, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "791f4c7abd6fa59f35dc7ade0d09dfe9" } } $('.js-work-strip[data-work-id=125338049]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125338049,"title":"A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C","translated_title":"","metadata":{"abstract":"Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism. Methods: Mice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31. We used hyperpolarized 13C MRS to investigate the metabolic exchange of pyruvate to lactate in real time during brain development following HI. 13C-1-labeled pyruvate was hyperpolarized and injected into the tail vein through a tail-vein catheter. Chemical-shift imaging was performed to acquire spectral-spatial information of the metabolites in the brain. A voxel placed on each of the injured and contralateral hemispheres was chosen for comparison. The difference in pyruvate delivery and lactate to pyruvate ratio was calculated for each of the voxels at each time point. The normalized lactate level of the injured hemisphere was also calculated for each mouse at each ...","publisher":"S. Karger AG","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Developmental Neuroscience"},"translated_abstract":"Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism. Methods: Mice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31. We used hyperpolarized 13C MRS to investigate the metabolic exchange of pyruvate to lactate in real time during brain development following HI. 13C-1-labeled pyruvate was hyperpolarized and injected into the tail vein through a tail-vein catheter. Chemical-shift imaging was performed to acquire spectral-spatial information of the metabolites in the brain. A voxel placed on each of the injured and contralateral hemispheres was chosen for comparison. The difference in pyruvate delivery and lactate to pyruvate ratio was calculated for each of the voxels at each time point. 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href="https://www.academia.edu/125338048/Erythropoietin_promotes_hippocampal_neurogenesis_in_in_vitro_models_of_neonatal_stroke"><img alt="Research paper thumbnail of Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke" class="work-thumbnail" src="https://attachments.academia-assets.com/119400375/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125338048/Erythropoietin_promotes_hippocampal_neurogenesis_in_in_vitro_models_of_neonatal_stroke">Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke</a></div><div class="wp-workCard_item"><span>Neurobiology of Disease</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125338047/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia">HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia</a></div><div class="wp-workCard_item"><span>Developmental Neuroscience</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HI...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HIF-1α) may promote cell survival in hypoxic or ischemic brain. To help understand the role of HIF-1α in neonatal hypoxic-ischemic brain injury, mice with conditional neuron-specific inactivation of HIF-1α underwent hypoxia-ischemia (HI). Mice heterozygous for Cre recombinase under the control of the calcium/calmodulin-dependent kinase II promoter were bred with homozygous ‘floxed’ HIF-1α transgenic mice. The resulting litters produced mice with a forebrain predominant neuronal deletion of HIF-1α (HIF-1αΔ/Δ), as well as littermates without the deletion. In order to verify reduction of HIF-1α at postnatal day 7, HIF-1αΔ/Δ and wild-type mice were exposed to a hypoxic stimulus (8% oxygen) or room air for 1 h, followed by immediate collection of brain cortices for determination of HIF-1α expression. Results of Western blotting of mouse cortices exposed to hypoxia stimulus or room air confirmed...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f3c87fbfb6c7bc5d11c178647c4802f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119400357,"asset_id":125338047,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/119400357/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125338047"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="125338047"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 125338047; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125338047]").text(description); $(".js-view-count[data-work-id=125338047]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 125338047; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='125338047']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 125338047, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f3c87fbfb6c7bc5d11c178647c4802f" } } $('.js-work-strip[data-work-id=125338047]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":125338047,"title":"HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HIF-1α) may promote cell survival in hypoxic or ischemic brain. 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profile--work_container" data-work-id="61229329"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229329/The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia"><img alt="Research paper thumbnail of The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia" class="work-thumbnail" src="https://attachments.academia-assets.com/74332951/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229329/The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia">The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia</a></div><div class="wp-workCard_item"><span>Developmental Neuroscience</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular dysfunction, inflammation, and oxidative stress, followed later by tissue repair. The key enzyme of these processes in the human body is arginase (ARG) that acts via the bioavailability of nitric oxide, and the synthesis of polyamines and proline. ARG is expressed throughout the brain in different cells. However, little is known about the effect of ARG in pathophysiological states of the brain, especially hypoxia-ischemia. Here, we summarize the role of ARG during neurodevelopment as well as in various brain pathologies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7bb79997b2d30747e6d8cce36abc4851" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74332951,"asset_id":61229329,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74332951/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229329"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229329"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229329; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229329]").text(description); $(".js-view-count[data-work-id=61229329]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229329; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229329']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229329, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7bb79997b2d30747e6d8cce36abc4851" } } $('.js-work-strip[data-work-id=61229329]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229329,"title":"The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular dysfunction, inflammation, and oxidative stress, followed later by tissue repair. The key enzyme of these processes in the human body is arginase (ARG) that acts via the bioavailability of nitric oxide, and the synthesis of polyamines and proline. ARG is expressed throughout the brain in different cells. However, little is known about the effect of ARG in pathophysiological states of the brain, especially hypoxia-ischemia. Here, we summarize the role of ARG during neurodevelopment as well as in various brain pathologies.","publisher":"S. Karger AG","publication_name":"Developmental Neuroscience"},"translated_abstract":"Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular dysfunction, inflammation, and oxidative stress, followed later by tissue repair. The key enzyme of these processes in the human body is arginase (ARG) that acts via the bioavailability of nitric oxide, and the synthesis of polyamines and proline. ARG is expressed throughout the brain in different cells. However, little is known about the effect of ARG in pathophysiological states of the brain, especially hypoxia-ischemia. Here, we summarize the role of ARG during neurodevelopment as well as in various brain pathologies.","internal_url":"https://www.academia.edu/61229329/The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia","translated_internal_url":"","created_at":"2021-11-07T13:26:51.913-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74332951,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74332951/thumbnails/1.jpg","file_name":"496467.pdf","download_url":"https://www.academia.edu/attachments/74332951/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Arginase_Pathway_in_Neonatal_Brain_H.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74332951/496467-libre.pdf?1636320610=\u0026response-content-disposition=attachment%3B+filename%3DThe_Arginase_Pathway_in_Neonatal_Brain_H.pdf\u0026Expires=1732410262\u0026Signature=CiOJgsvMMeszDG~S3cAaWFjuV0QLevhhP2LUA1YI9RbMTTUfFQLLVRqLOe8mpT4-OjU-YnlwjIpEcz6XBJ~MRM7bt6ypLyP1konvW0QYDXAknq9UOSmxdxlGUDS26VirZ3R1NDxrchexYSTeOv57si-nJW5DMcvr0zZ3-waWiVZ6co1GLF8r2Yeroj2iN47CLE20q-d7Wy~fPSz7QwbPOY~bS1RzzNEwsOTUMFjENIwcQRbq9Y81-H1He6qvotpJyWpzAJv6igOzcAvQnoyDOSuT1WafpbDrNV7QQe1i0ibSfg7Jhex95ja06XHwrWkDcGPDa0C2hzrM6RwVIlXlOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Arginase_Pathway_in_Neonatal_Brain_Hypoxia_Ischemia","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74332951,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74332951/thumbnails/1.jpg","file_name":"496467.pdf","download_url":"https://www.academia.edu/attachments/74332951/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Arginase_Pathway_in_Neonatal_Brain_H.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74332951/496467-libre.pdf?1636320610=\u0026response-content-disposition=attachment%3B+filename%3DThe_Arginase_Pathway_in_Neonatal_Brain_H.pdf\u0026Expires=1732410262\u0026Signature=CiOJgsvMMeszDG~S3cAaWFjuV0QLevhhP2LUA1YI9RbMTTUfFQLLVRqLOe8mpT4-OjU-YnlwjIpEcz6XBJ~MRM7bt6ypLyP1konvW0QYDXAknq9UOSmxdxlGUDS26VirZ3R1NDxrchexYSTeOv57si-nJW5DMcvr0zZ3-waWiVZ6co1GLF8r2Yeroj2iN47CLE20q-d7Wy~fPSz7QwbPOY~bS1RzzNEwsOTUMFjENIwcQRbq9Y81-H1He6qvotpJyWpzAJv6igOzcAvQnoyDOSuT1WafpbDrNV7QQe1i0ibSfg7Jhex95ja06XHwrWkDcGPDa0C2hzrM6RwVIlXlOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":74332952,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74332952/thumbnails/1.jpg","file_name":"496467.pdf","download_url":"https://www.academia.edu/attachments/74332952/download_file","bulk_download_file_name":"The_Arginase_Pathway_in_Neonatal_Brain_H.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74332952/496467-libre.pdf?1636320609=\u0026response-content-disposition=attachment%3B+filename%3DThe_Arginase_Pathway_in_Neonatal_Brain_H.pdf\u0026Expires=1732410262\u0026Signature=I8MrJhbcqlD1A7uOM~lqNoSyCPXd40FaeMpCqe06nzXP4OEBY5jm2~cYnXW6lVuRQjp4d4ZF8V5WzwvP7b9MwpF0PX1vGoxCZKz2F0AmiRGQgh8MCBdWjN8R-0evfL~dibFFBJARiWYj1SszaYZESHJ1NrnS9vSXONer-CKGWUUlA7kINCGadgvQdamxIeJBG~-oFLWOxYowN5q7lb7N72JXUP0v2vJlpXJe1srUwyDRHjV61O2MITcaJvn5jywURhVgucVttnMBgVqYFZbpjvwOuaeQ00oueQ2lVPcByJiIPYCnnZIfrlJf0~-NHnP9z7-nmN0yJNBzhdYsRZlrTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":8322,"name":"Developmental neuroscience","url":"https://www.academia.edu/Documents/in/Developmental_neuroscience"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":14092825,"url":"https://www.karger.com/Article/Pdf/496467"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229328"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229328/Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia"><img alt="Research paper thumbnail of Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia" class="work-thumbnail" src="https://attachments.academia-assets.com/74333013/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229328/Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia">Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia</a></div><div class="wp-workCard_item"><span>Pediatric research</span><span>, Jan 3, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming. We studied those neonates with a normal/mildly abnormal EEG during the first 24 h of monitoring. A total of 331 neonates were treated with hypothermia and 323 had cEEG recordings available for review; 99 were excluded because of a moderately/severely abnormal cEEG background and/or seizure during the first 24 h of recording, and an additional eight because of early rewarming. The remaining 216 had a normal/mildly abnormal cEEG in the first 24 h. None of these patients subsequently developed seizures. A normal/mildly abnor...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0c35ae8aaa8b51b2d388a3b489a343c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333013,"asset_id":61229328,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333013/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229328"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229328"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229328; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229328]").text(description); $(".js-view-count[data-work-id=61229328]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229328; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229328']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229328, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0c35ae8aaa8b51b2d388a3b489a343c7" } } $('.js-work-strip[data-work-id=61229328]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229328,"title":"Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia","translated_title":"","metadata":{"abstract":"To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming. We studied those neonates with a normal/mildly abnormal EEG during the first 24 h of monitoring. A total of 331 neonates were treated with hypothermia and 323 had cEEG recordings available for review; 99 were excluded because of a moderately/severely abnormal cEEG background and/or seizure during the first 24 h of recording, and an additional eight because of early rewarming. The remaining 216 had a normal/mildly abnormal cEEG in the first 24 h. None of these patients subsequently developed seizures. A normal/mildly abnor...","publication_date":{"day":3,"month":1,"year":2018,"errors":{}},"publication_name":"Pediatric research"},"translated_abstract":"To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming. We studied those neonates with a normal/mildly abnormal EEG during the first 24 h of monitoring. A total of 331 neonates were treated with hypothermia and 323 had cEEG recordings available for review; 99 were excluded because of a moderately/severely abnormal cEEG background and/or seizure during the first 24 h of recording, and an additional eight because of early rewarming. The remaining 216 had a normal/mildly abnormal cEEG in the first 24 h. None of these patients subsequently developed seizures. A normal/mildly abnor...","internal_url":"https://www.academia.edu/61229328/Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia","translated_internal_url":"","created_at":"2021-11-07T13:26:51.794-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333013,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333013/thumbnails/1.jpg","file_name":"s41390-018-0040-x.pdf","download_url":"https://www.academia.edu/attachments/74333013/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Predictive_value_of_early_EEG_for_seizur.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333013/s41390-018-0040-x-libre.pdf?1636320606=\u0026response-content-disposition=attachment%3B+filename%3DPredictive_value_of_early_EEG_for_seizur.pdf\u0026Expires=1732410262\u0026Signature=J-MYMp3KTVXRRMC9gLRX7VQatno~6GGSY7WeeOP17eXscmDm7J~wCooU7P0mXsGBBE~kHSstaMbVYcdV1rZBciRYe3le6A-eMOczAhEZiLTGR~PUh5dgrNEKyfSJCu07sFmx~5bQ-qJ~HKSHGX1v0qUeIO9f2~qqoN~Y~WkztZ5DMeLAaFUmSYIaAlAd6bppxMasRkTmeB1L2faG9vNyHnmOulFVRzwrZSZVln8n5cF9YDoNy5dhlYUrZA5TsixTd7lV77Wr29HTsNNhreh~92afbIcY5smQkjEdk2yYGfiTlzEjWQbwZ0mu2tY1mjOJbYQX1F5rxqN5AD9H7teUKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Predictive_value_of_early_EEG_for_seizures_in_neonates_with_hypoxic_ischemic_encephalopathy_undergoing_therapeutic_hypothermia","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333013,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333013/thumbnails/1.jpg","file_name":"s41390-018-0040-x.pdf","download_url":"https://www.academia.edu/attachments/74333013/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Predictive_value_of_early_EEG_for_seizur.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333013/s41390-018-0040-x-libre.pdf?1636320606=\u0026response-content-disposition=attachment%3B+filename%3DPredictive_value_of_early_EEG_for_seizur.pdf\u0026Expires=1732410262\u0026Signature=J-MYMp3KTVXRRMC9gLRX7VQatno~6GGSY7WeeOP17eXscmDm7J~wCooU7P0mXsGBBE~kHSstaMbVYcdV1rZBciRYe3le6A-eMOczAhEZiLTGR~PUh5dgrNEKyfSJCu07sFmx~5bQ-qJ~HKSHGX1v0qUeIO9f2~qqoN~Y~WkztZ5DMeLAaFUmSYIaAlAd6bppxMasRkTmeB1L2faG9vNyHnmOulFVRzwrZSZVln8n5cF9YDoNy5dhlYUrZA5TsixTd7lV77Wr29HTsNNhreh~92afbIcY5smQkjEdk2yYGfiTlzEjWQbwZ0mu2tY1mjOJbYQX1F5rxqN5AD9H7teUKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229327"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229327/Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain"><img alt="Research paper thumbnail of Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain" class="work-thumbnail" src="https://attachments.academia-assets.com/74333015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229327/Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain">Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain</a></div><div class="wp-workCard_item"><span>Pediatric research</span><span>, Jan 2, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain choleste...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the impact of hypoxia-ischemia (HI) on brain cholesterol metabolism in the neonatal mice.MethodsPostnatal day 9 C57BL/6 pups were subjected to HI using the Vannucci model. CYP46A1 expression was assessed with western blotting and its cellular localization was determined using immunofluorescence staining. The amount of brain cholesterol, 24S-HC in the cortex and in the serum, was measured with enzyme-linked immunosorbent assay (ELISA).ResultsThere was a transient cholesterol loss at 6 h after HI. CYP46A1 was significantly upregulated at 6 and 24 h following HI with a concomitant increase of 24S-HC in the ipsilateral cortex and in the serum. The serum levels of 24S-HC correlated with those in the brain, a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="224438ec8049aff8ba64772433ed60ca" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333015,"asset_id":61229327,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333015/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229327"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229327"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229327; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229327]").text(description); $(".js-view-count[data-work-id=61229327]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229327; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229327']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229327, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "224438ec8049aff8ba64772433ed60ca" } } $('.js-work-strip[data-work-id=61229327]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229327,"title":"Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain","translated_title":"","metadata":{"abstract":"BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the impact of hypoxia-ischemia (HI) on brain cholesterol metabolism in the neonatal mice.MethodsPostnatal day 9 C57BL/6 pups were subjected to HI using the Vannucci model. CYP46A1 expression was assessed with western blotting and its cellular localization was determined using immunofluorescence staining. The amount of brain cholesterol, 24S-HC in the cortex and in the serum, was measured with enzyme-linked immunosorbent assay (ELISA).ResultsThere was a transient cholesterol loss at 6 h after HI. CYP46A1 was significantly upregulated at 6 and 24 h following HI with a concomitant increase of 24S-HC in the ipsilateral cortex and in the serum. The serum levels of 24S-HC correlated with those in the brain, a...","publication_date":{"day":2,"month":1,"year":2018,"errors":{}},"publication_name":"Pediatric research"},"translated_abstract":"BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the impact of hypoxia-ischemia (HI) on brain cholesterol metabolism in the neonatal mice.MethodsPostnatal day 9 C57BL/6 pups were subjected to HI using the Vannucci model. CYP46A1 expression was assessed with western blotting and its cellular localization was determined using immunofluorescence staining. The amount of brain cholesterol, 24S-HC in the cortex and in the serum, was measured with enzyme-linked immunosorbent assay (ELISA).ResultsThere was a transient cholesterol loss at 6 h after HI. CYP46A1 was significantly upregulated at 6 and 24 h following HI with a concomitant increase of 24S-HC in the ipsilateral cortex and in the serum. The serum levels of 24S-HC correlated with those in the brain, a...","internal_url":"https://www.academia.edu/61229327/Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain","translated_internal_url":"","created_at":"2021-11-07T13:26:51.680-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333015/thumbnails/1.jpg","file_name":"pr201849.pdf","download_url":"https://www.academia.edu/attachments/74333015/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Upregulation_of_cholesterol_24_hydroxyla.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333015/pr201849-libre.pdf?1636320607=\u0026response-content-disposition=attachment%3B+filename%3DUpregulation_of_cholesterol_24_hydroxyla.pdf\u0026Expires=1732410262\u0026Signature=Ow5KFEGJHKLZs~CAf23iQRy-W-0vbjaBJubuzpjz5TQZsPwvkyhuPwi2nWFdMZfeaEUR27qs1FU6-~koVp~SwB07fSqrETlHF9ZL8~Z0-CmeBkiTpKHne8NYzYnioFsnjYMrnRqeOoJ4ZzzzXyfptbAYQ6e3l1AAKTr-4ODaqY~SCgzeSr2O~vrDVOYNyzRbOucpIVwFkIOgEG~9wn5VbzKEfcmoaLBTlpqtQU~2KuL8rGYfIl9Jc44SDUHB~kmhITUEfWNpLbdgsiPAVn-3Wb7DQ-fVdq0HBj2nHJ5WGSa95HiGnsoPd1-JQ2aElo2aYWd-GIrkLi3BN6bonbbURA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Upregulation_of_cholesterol_24_hydroxylase_following_hypoxia_ischemia_in_neonatal_mouse_brain","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333015/thumbnails/1.jpg","file_name":"pr201849.pdf","download_url":"https://www.academia.edu/attachments/74333015/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Upregulation_of_cholesterol_24_hydroxyla.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333015/pr201849-libre.pdf?1636320607=\u0026response-content-disposition=attachment%3B+filename%3DUpregulation_of_cholesterol_24_hydroxyla.pdf\u0026Expires=1732410262\u0026Signature=Ow5KFEGJHKLZs~CAf23iQRy-W-0vbjaBJubuzpjz5TQZsPwvkyhuPwi2nWFdMZfeaEUR27qs1FU6-~koVp~SwB07fSqrETlHF9ZL8~Z0-CmeBkiTpKHne8NYzYnioFsnjYMrnRqeOoJ4ZzzzXyfptbAYQ6e3l1AAKTr-4ODaqY~SCgzeSr2O~vrDVOYNyzRbOucpIVwFkIOgEG~9wn5VbzKEfcmoaLBTlpqtQU~2KuL8rGYfIl9Jc44SDUHB~kmhITUEfWNpLbdgsiPAVn-3Wb7DQ-fVdq0HBj2nHJ5WGSa95HiGnsoPd1-JQ2aElo2aYWd-GIrkLi3BN6bonbbURA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229326"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229326/Dyslipidemia_in_Children_With_Arterial_Ischemic_Stroke_Prevalence_and_Risk_Factors"><img alt="Research paper thumbnail of Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors" class="work-thumbnail" src="https://attachments.academia-assets.com/74333009/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229326/Dyslipidemia_in_Children_With_Arterial_Ischemic_Stroke_Prevalence_and_Risk_Factors">Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors</a></div><div class="wp-workCard_item"><span>Pediatric neurology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Risk factors for pediatric stroke are poorly understood and require study to improve prevention. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non-high-density lipoprotein cholesterol, and hypertriglyceridemia. Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5020d30e65d7912b379b5ae2f31bcd50" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333009,"asset_id":61229326,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333009/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229326"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229326"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229326; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229326]").text(description); $(".js-view-count[data-work-id=61229326]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229326; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229326']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229326, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5020d30e65d7912b379b5ae2f31bcd50" } } $('.js-work-strip[data-work-id=61229326]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229326,"title":"Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors","translated_title":"","metadata":{"abstract":"Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non-high-density lipoprotein cholesterol, and hypertriglyceridemia. Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Pediatric neurology"},"translated_abstract":"Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non-high-density lipoprotein cholesterol, and hypertriglyceridemia. Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol...","internal_url":"https://www.academia.edu/61229326/Dyslipidemia_in_Children_With_Arterial_Ischemic_Stroke_Prevalence_and_Risk_Factors","translated_internal_url":"","created_at":"2021-11-07T13:26:51.564-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333009,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333009/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/74333009/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dyslipidemia_in_Children_With_Arterial_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333009/pdf-libre.pdf?1636320607=\u0026response-content-disposition=attachment%3B+filename%3DDyslipidemia_in_Children_With_Arterial_I.pdf\u0026Expires=1732410262\u0026Signature=Vrshi2WAp6brY1UFxQyeoEhuio-syHuS0OnOfRBA3C1UlrHlm1eJQ~ysqeeOAjBUKSys9CjJ7uDYkmGUIth58Fs1vemNzjNdUXNic-Kwl~5KKT4KRyLStufPcsiFJi3ZL8bxK15qn2MWizXz0jncnlM-rYNBPlD5K1iOn~AjaF3R7hbaVC7bo6qf-mFjbsuOuzuSqgRo4f6XkenwsA-fjYEgqJa~CdeiGrmYg7tTdtuqF3rJZ0j6OnpfqLiPvIG2XcMCvtopDXuQIuE~cU2Dd6hsFTTPofeIj6EPCvm~KxvoVRC1R3zHfa0KNowGY5k2Sg6qX4gTItizfg1reCdjcQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dyslipidemia_in_Children_With_Arterial_Ischemic_Stroke_Prevalence_and_Risk_Factors","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333009,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333009/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/74333009/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dyslipidemia_in_Children_With_Arterial_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333009/pdf-libre.pdf?1636320607=\u0026response-content-disposition=attachment%3B+filename%3DDyslipidemia_in_Children_With_Arterial_I.pdf\u0026Expires=1732410262\u0026Signature=Vrshi2WAp6brY1UFxQyeoEhuio-syHuS0OnOfRBA3C1UlrHlm1eJQ~ysqeeOAjBUKSys9CjJ7uDYkmGUIth58Fs1vemNzjNdUXNic-Kwl~5KKT4KRyLStufPcsiFJi3ZL8bxK15qn2MWizXz0jncnlM-rYNBPlD5K1iOn~AjaF3R7hbaVC7bo6qf-mFjbsuOuzuSqgRo4f6XkenwsA-fjYEgqJa~CdeiGrmYg7tTdtuqF3rJZ0j6OnpfqLiPvIG2XcMCvtopDXuQIuE~cU2Dd6hsFTTPofeIj6EPCvm~KxvoVRC1R3zHfa0KNowGY5k2Sg6qX4gTItizfg1reCdjcQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":37791,"name":"Pediatric Neurology","url":"https://www.academia.edu/Documents/in/Pediatric_Neurology"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229325"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229325/Association_of_Histologic_Chorioamnionitis_With_Perinatal_Brain_Injury_and_Early_Childhood_Neurodevelopmental_Outcomes_Among_Preterm_Neonates"><img alt="Research paper thumbnail of Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates" class="work-thumbnail" src="https://attachments.academia-assets.com/74333008/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229325/Association_of_Histologic_Chorioamnionitis_With_Perinatal_Brain_Injury_and_Early_Childhood_Neurodevelopmental_Outcomes_Among_Preterm_Neonates">Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates</a></div><div class="wp-workCard_item"><span>JAMA pediatrics</span><span>, Jan 2, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the patho...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood. Prospective cohort study conducted across 3 academic centers (from April 2006 to September 2013 in Canada, from March 2007 to March 2013 in the Netherlands, and from January 2004 to August 2011 in the United States). Children who were born preterm (24-32 weeks&#39; gestation) and who had undergone a placental pathologic evaluation, magnetic resonance imaging as soon as clinically stable, and Bayley Scales of Infant and Toddler Development, Third Edit...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4200be58139ddbf079435851e2faa4df" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333008,"asset_id":61229325,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333008/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229325"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229325"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229325; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229325]").text(description); $(".js-view-count[data-work-id=61229325]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229325; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229325']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229325, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4200be58139ddbf079435851e2faa4df" } } $('.js-work-strip[data-work-id=61229325]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229325,"title":"Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates","translated_title":"","metadata":{"abstract":"Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood. Prospective cohort study conducted across 3 academic centers (from April 2006 to September 2013 in Canada, from March 2007 to March 2013 in the Netherlands, and from January 2004 to August 2011 in the United States). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229324"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229324/Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats"><img alt="Research paper thumbnail of Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229324/Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats">Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats</a></div><div class="wp-workCard_item"><span>Journal of Neuroscience Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including stroke and neonatal ischemic brain injury. Delayed intranasal administration of mesenchymal stem cells (MSCs) after experimental hypoxia-ischemia and after a transient middle cerebral artery occlusion (tMCAO) in neonatal rats has shown improvement in long-term functional outcomes, but the effects of MSCs on white matter injury (WMI) are insufficiently understood. In this study we used longitudinal T2-weighted (T2W) and diffusion tensor magnetic resonance imaging (MRI) to characterize chronic injury after tMCAO induced in postnatal day 10 (P10) rats and examined the effects of delayed MSC administration on WMI, axonal coverage, and long-term somatosensory function. We show unilateral injury- and region-dependent changes in diffusion fraction anisotropy 1 and 2 weeks after tMCAO that correspond to accumulation of degraded myelin basic protein, astrocytosis, and decreased axonal coverage. With the use of stringent T2W-based injury criteria at 72 hr after tMCAO to randomize neonatal rats to receive intranasal MSCs or vehicle, we show that a single MSC administration attenuates WMI and enhances somatosensory function 28 days after stroke. A positive correlation was found between MSC-enhanced white matter integrity and functional performance in injured neonatal rats. Collectively, these data indicate that the damage induced by tMCAO progresses over time and is halted by administration of MSCs. © 2016 Wiley Periodicals, Inc.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229324"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229324"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229324; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229324]").text(description); $(".js-view-count[data-work-id=61229324]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229324; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229324']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229324, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=61229324]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229324,"title":"Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats","translated_title":"","metadata":{"abstract":"Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including stroke and neonatal ischemic brain injury. Delayed intranasal administration of mesenchymal stem cells (MSCs) after experimental hypoxia-ischemia and after a transient middle cerebral artery occlusion (tMCAO) in neonatal rats has shown improvement in long-term functional outcomes, but the effects of MSCs on white matter injury (WMI) are insufficiently understood. In this study we used longitudinal T2-weighted (T2W) and diffusion tensor magnetic resonance imaging (MRI) to characterize chronic injury after tMCAO induced in postnatal day 10 (P10) rats and examined the effects of delayed MSC administration on WMI, axonal coverage, and long-term somatosensory function. We show unilateral injury- and region-dependent changes in diffusion fraction anisotropy 1 and 2 weeks after tMCAO that correspond to accumulation of degraded myelin basic protein, astrocytosis, and decreased axonal coverage. With the use of stringent T2W-based injury criteria at 72 hr after tMCAO to randomize neonatal rats to receive intranasal MSCs or vehicle, we show that a single MSC administration attenuates WMI and enhances somatosensory function 28 days after stroke. A positive correlation was found between MSC-enhanced white matter integrity and functional performance in injured neonatal rats. Collectively, these data indicate that the damage induced by tMCAO progresses over time and is halted by administration of MSCs. © 2016 Wiley Periodicals, Inc.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Journal of Neuroscience Research"},"translated_abstract":"Cell therapy has emerged as a potential treatment for many neurodegenerative diseases including stroke and neonatal ischemic brain injury. Delayed intranasal administration of mesenchymal stem cells (MSCs) after experimental hypoxia-ischemia and after a transient middle cerebral artery occlusion (tMCAO) in neonatal rats has shown improvement in long-term functional outcomes, but the effects of MSCs on white matter injury (WMI) are insufficiently understood. In this study we used longitudinal T2-weighted (T2W) and diffusion tensor magnetic resonance imaging (MRI) to characterize chronic injury after tMCAO induced in postnatal day 10 (P10) rats and examined the effects of delayed MSC administration on WMI, axonal coverage, and long-term somatosensory function. We show unilateral injury- and region-dependent changes in diffusion fraction anisotropy 1 and 2 weeks after tMCAO that correspond to accumulation of degraded myelin basic protein, astrocytosis, and decreased axonal coverage. With the use of stringent T2W-based injury criteria at 72 hr after tMCAO to randomize neonatal rats to receive intranasal MSCs or vehicle, we show that a single MSC administration attenuates WMI and enhances somatosensory function 28 days after stroke. A positive correlation was found between MSC-enhanced white matter integrity and functional performance in injured neonatal rats. Collectively, these data indicate that the damage induced by tMCAO progresses over time and is halted by administration of MSCs. © 2016 Wiley Periodicals, Inc.","internal_url":"https://www.academia.edu/61229324/Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats","translated_internal_url":"","created_at":"2021-11-07T13:26:51.341-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Mesenchymal_stem_cells_attenuate_MRI_identifiable_injury_protect_white_matter_and_improve_long_term_functional_outcomes_after_neonatal_focal_stroke_in_rats","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229323"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229323/Antenatal_Exposure_to_Magnesium_Sulfate_Is_Associated_with_Reduced_Cerebellar_Hemorrhage_in_Preterm_Newborns"><img alt="Research paper thumbnail of Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns" class="work-thumbnail" src="https://attachments.academia-assets.com/74333010/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229323/Antenatal_Exposure_to_Magnesium_Sulfate_Is_Associated_with_Reduced_Cerebellar_Hemorrhage_in_Preterm_Newborns">Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns</a></div><div class="wp-workCard_item"><span>The Journal of pediatrics</span><span>, Jan 22, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To determine the association of antenatal magnesium sulfate with cerebellar hemorrhage in a prosp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To determine the association of antenatal magnesium sulfate with cerebellar hemorrhage in a prospective cohort of premature newborns evaluated by magnetic resonance imaging (MRI). Cross-sectional analysis of baseline characteristics from a prospective cohort of preterm newborns (&lt;33 weeks gestation) evaluated with 3T-MRI shortly after birth. Exclusion criteria were clinical evidence of a congenital syndrome, congenital infection, or clinical status too unstable for transport to MRI. Antenatal magnesium sulfate exposure was abstracted from the medical records and the indication was classified as obstetric or neuroprotection. Two pediatric neuroradiologists, blinded to the clinical history, scored axial T2-weighted and iron susceptibility MRI sequences for cerebellar hemorrhage. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229320"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229320/Delayed_erythropoietin_therapy_improves_histological_and_behavioral_outcomes_after_transient_neonatal_stroke"><img alt="Research paper thumbnail of Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229320/Delayed_erythropoietin_therapy_improves_histological_and_behavioral_outcomes_after_transient_neonatal_stroke">Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke</a></div><div class="wp-workCard_item"><span>Neurobiology of disease</span><span>, Sep 30, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Stroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Stroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted therapeutic options. The purpose of this study is to investigate the efficacy of delayed initiation of multiple dose erythropoietin (EPO) therapy in improving histological and behavioral outcomes after early transient ischemic stroke. 32 postnatal day 10 (P10) Sprague-Dawley rats underwent sham surgery or transient middle cerebral artery occlusion (tMCAO) for 3h, resulting in injury involving the striatum and parieto-temporal cortex. EPO (1000U/kg per dose×3 doses) or vehicle was administered intraperitoneally starting one week after tMCAO (at P17, P20, and P23). At four weeks after tMCAO, sensorimotor function was assessed in these four groups (6 vehicle-sham, 6 EPO-sham, 10 vehicle-tMCAO and 10 EPO-tMCAO) with forepaw preference in cylinder rearing trials. Brains were then harvested for hemispheric volume and Western blot analysis. EPO-tMCAO animals had significant improvement in forep...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229320"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229320"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229320; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229320]").text(description); $(".js-view-count[data-work-id=61229320]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229320; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229320']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229320, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=61229320]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229320,"title":"Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke","translated_title":"","metadata":{"abstract":"Stroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted therapeutic options. 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EPO-tMCAO animals had significant improvement in forep...","publication_date":{"day":30,"month":9,"year":2016,"errors":{}},"publication_name":"Neurobiology of disease"},"translated_abstract":"Stroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted therapeutic options. The purpose of this study is to investigate the efficacy of delayed initiation of multiple dose erythropoietin (EPO) therapy in improving histological and behavioral outcomes after early transient ischemic stroke. 32 postnatal day 10 (P10) Sprague-Dawley rats underwent sham surgery or transient middle cerebral artery occlusion (tMCAO) for 3h, resulting in injury involving the striatum and parieto-temporal cortex. EPO (1000U/kg per dose×3 doses) or vehicle was administered intraperitoneally starting one week after tMCAO (at P17, P20, and P23). At four weeks after tMCAO, sensorimotor function was assessed in these four groups (6 vehicle-sham, 6 EPO-sham, 10 vehicle-tMCAO and 10 EPO-tMCAO) with forepaw preference in cylinder rearing trials. Brains were then harvested for hemispheric volume and Western blot analysis. 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However, this protection is reversed with hypoxia preconditioning, raising the question of the roles of the genes regulated by hypoxia-inducible factor-1α (HIF-1α) and their transcription products, such as erythropoietin (EPO), in both the initial protection and subsequent reversal of protection. hGPx-tg and their wild-type (WT) littermates underwent the Vannucci procedure of HI brain injury at postnatal day 9 - left carotid artery ligation followed by exposure to 10% oxygen for 50 min. Brain cortices and hippocampi were subsequently collected 0.5, 4 and 24 h later for the determination of protein expression by Western blot for GPx, HIF-1α, HIF-2α, EPO, EPO receptor, ERK1/2, phospho-ERK1/2, spectrin 145/150 (as a marker of calpain-specific necrotic cell death), and spectrin ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="af92d7318ad6c1d855a06a611c9b492e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333074,"asset_id":61229319,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333074/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229319"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229319"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229319; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229319]").text(description); $(".js-view-count[data-work-id=61229319]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229319; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229319']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229319, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "af92d7318ad6c1d855a06a611c9b492e" } } $('.js-work-strip[data-work-id=61229319]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229319,"title":"Alteration in Downstream Hypoxia Gene Signaling in Neonatal Glutathione Peroxidase Overexpressing Mouse Brain after Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"We have previously shown that glutathione peroxidase (GPx) overexpressing mice (hGPx-tg) have reduced brain injury after neonatal hypoxia-ischemia (HI) as a consequence of reduced hydrogen peroxide accumulation. However, this protection is reversed with hypoxia preconditioning, raising the question of the roles of the genes regulated by hypoxia-inducible factor-1α (HIF-1α) and their transcription products, such as erythropoietin (EPO), in both the initial protection and subsequent reversal of protection. hGPx-tg and their wild-type (WT) littermates underwent the Vannucci procedure of HI brain injury at postnatal day 9 - left carotid artery ligation followed by exposure to 10% oxygen for 50 min. Brain cortices and hippocampi were subsequently collected 0.5, 4 and 24 h later for the determination of protein expression by Western blot for GPx, HIF-1α, HIF-2α, EPO, EPO receptor, ERK1/2, phospho-ERK1/2, spectrin 145/150 (as a marker of calpain-specific necrotic cell death), and spectrin ...","publication_date":{"day":17,"month":1,"year":2015,"errors":{}},"publication_name":"Developmental neuroscience"},"translated_abstract":"We have previously shown that glutathione peroxidase (GPx) overexpressing mice (hGPx-tg) have reduced brain injury after neonatal hypoxia-ischemia (HI) as a consequence of reduced hydrogen peroxide accumulation. 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Brain cortices and hippocampi were subsequently collected 0.5, 4 and 24 h later for the determination of protein expression by Western blot for GPx, HIF-1α, HIF-2α, EPO, EPO receptor, ERK1/2, phospho-ERK1/2, spectrin 145/150 (as a marker of calpain-specific necrotic cell death), and spectrin ...","internal_url":"https://www.academia.edu/61229319/Alteration_in_Downstream_Hypoxia_Gene_Signaling_in_Neonatal_Glutathione_Peroxidase_Overexpressing_Mouse_Brain_after_Hypoxia_Ischemia","translated_internal_url":"","created_at":"2021-11-07T13:26:50.707-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33003560,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":74333074,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333074/thumbnails/1.jpg","file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf","download_url":"https://www.academia.edu/attachments/74333074/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333074/Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf?1636320498=\u0026response-content-disposition=attachment%3B+filename%3DAlteration_in_Downstream_Hypoxia_Gene_Si.pdf\u0026Expires=1732410262\u0026Signature=T5aHUnkPQfUSKIIEFog8VOjCqZNZdlsTNFa9-wQ3xsw1Pw8BnG20TyosZj-5d1Foq92ejLFqRmd~~43diRIyzNXzOI2vjAF04wRlir1eRES-N899G-D~o-BHPv1nZPgceesR0pJCEtcY~Saa~E9WXRWk0Mpfg3ldbRqBJBZbZDeht-Khe3AgLLJUeoJAuW24mbdU-3eyRv~u6zlWS3RS27r0zH4fCu3PAhshXUBN-xLe1ngT-3AhhO7plwMvdfvR8dBckT9wxz4fBIjAfIMypWHsgyhP3TQNJa2mBTb4RY0I0bgM8QCWlntmwRsfJQj0M0dWEDONMb0GVHllTYidtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Alteration_in_Downstream_Hypoxia_Gene_Signaling_in_Neonatal_Glutathione_Peroxidase_Overexpressing_Mouse_Brain_after_Hypoxia_Ischemia","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":33003560,"first_name":"Donna","middle_initials":null,"last_name":"Ferriero","page_name":"DonnaFerriero","domain_name":"ucsf","created_at":"2015-07-12T08:19:22.794-07:00","display_name":"Donna Ferriero","url":"https://ucsf.academia.edu/DonnaFerriero"},"attachments":[{"id":74333074,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/74333074/thumbnails/1.jpg","file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf","download_url":"https://www.academia.edu/attachments/74333074/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alteration_in_Downstream_Hypoxia_Gene_Si.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/74333074/Alteration_in_Downstream_Hypoxia_Gene_Si20211107-18288-1profam.pdf?1636320498=\u0026response-content-disposition=attachment%3B+filename%3DAlteration_in_Downstream_Hypoxia_Gene_Si.pdf\u0026Expires=1732410262\u0026Signature=T5aHUnkPQfUSKIIEFog8VOjCqZNZdlsTNFa9-wQ3xsw1Pw8BnG20TyosZj-5d1Foq92ejLFqRmd~~43diRIyzNXzOI2vjAF04wRlir1eRES-N899G-D~o-BHPv1nZPgceesR0pJCEtcY~Saa~E9WXRWk0Mpfg3ldbRqBJBZbZDeht-Khe3AgLLJUeoJAuW24mbdU-3eyRv~u6zlWS3RS27r0zH4fCu3PAhshXUBN-xLe1ngT-3AhhO7plwMvdfvR8dBckT9wxz4fBIjAfIMypWHsgyhP3TQNJa2mBTb4RY0I0bgM8QCWlntmwRsfJQj0M0dWEDONMb0GVHllTYidtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":8322,"name":"Developmental neuroscience","url":"https://www.academia.edu/Documents/in/Developmental_neuroscience"},{"id":37931,"name":"Transgenic Mice","url":"https://www.academia.edu/Documents/in/Transgenic_Mice"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":141395,"name":"Glutathione Peroxidase","url":"https://www.academia.edu/Documents/in/Glutathione_Peroxidase"},{"id":177250,"name":"ERK","url":"https://www.academia.edu/Documents/in/ERK"},{"id":213910,"name":"Mitogen Activated Protein Kinase","url":"https://www.academia.edu/Documents/in/Mitogen_Activated_Protein_Kinase"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":2754174,"name":"Hypoxia inducible factor","url":"https://www.academia.edu/Documents/in/Hypoxia_inducible_factor"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229317"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229317/Patterns_and_implications_of_MR_contrast_enhancement_in_perinatal_asphyxia_a_preliminary_report"><img alt="Research paper thumbnail of Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report" class="work-thumbnail" src="https://attachments.academia-assets.com/74333067/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229317/Patterns_and_implications_of_MR_contrast_enhancement_in_perinatal_asphyxia_a_preliminary_report">Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report</a></div><div class="wp-workCard_item"><span>AJNR. American journal of neuroradiology</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To determine the presence and location of MR contrast enhancement in infants with perinatal asphy...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To determine the presence and location of MR contrast enhancement in infants with perinatal asphyxia and to evaluate the utility of enhancement in assessing extent of brain damage. Precontrast and postcontrast MR examinations within the first 10 days of life were evaluated in 10 infants with suspected hypoxic-ischemic birth injury. Findings were correlated with clinical birth history and short-term neurologic follow-up. All four infants with MR signal abnormalities and contrast enhancement in the basal ganglia and brain stem had early seizures and profound neurologic deficits at early follow-up. Two infants had abnormal scans but no contrast enhancement; one with MR signal abnormality within the basal ganglia is neurologically healthy at 10-month follow-up, whereas the other, in status epilepticus at the time of imaging at age 2 days, died. Two infants with minimal parasagittal subcortical white matter enhancement had no early seizure activity and only mild developmental delay at ea...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="359d69f21e808610a22f54f55dda6a40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333067,"asset_id":61229317,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333067/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229317"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229317"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229317; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229317]").text(description); $(".js-view-count[data-work-id=61229317]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229317; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229317']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229317, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "359d69f21e808610a22f54f55dda6a40" } } $('.js-work-strip[data-work-id=61229317]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229317,"title":"Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report","translated_title":"","metadata":{"abstract":"To determine the presence and location of MR contrast enhancement in infants with perinatal asphyxia and to evaluate the utility of enhancement in assessing extent of brain damage. Precontrast and postcontrast MR examinations within the first 10 days of life were evaluated in 10 infants with suspected hypoxic-ischemic birth injury. Findings were correlated with clinical birth history and short-term neurologic follow-up. All four infants with MR signal abnormalities and contrast enhancement in the basal ganglia and brain stem had early seizures and profound neurologic deficits at early follow-up. Two infants had abnormal scans but no contrast enhancement; one with MR signal abnormality within the basal ganglia is neurologically healthy at 10-month follow-up, whereas the other, in status epilepticus at the time of imaging at age 2 days, died. Two infants with minimal parasagittal subcortical white matter enhancement had no early seizure activity and only mild developmental delay at ea...","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"AJNR. American journal of neuroradiology"},"translated_abstract":"To determine the presence and location of MR contrast enhancement in infants with perinatal asphyxia and to evaluate the utility of enhancement in assessing extent of brain damage. Precontrast and postcontrast MR examinations within the first 10 days of life were evaluated in 10 infants with suspected hypoxic-ischemic birth injury. Findings were correlated with clinical birth history and short-term neurologic follow-up. All four infants with MR signal abnormalities and contrast enhancement in the basal ganglia and brain stem had early seizures and profound neurologic deficits at early follow-up. Two infants had abnormal scans but no contrast enhancement; one with MR signal abnormality within the basal ganglia is neurologically healthy at 10-month follow-up, whereas the other, in status epilepticus at the time of imaging at age 2 days, died. Two infants with minimal parasagittal subcortical white matter enhancement had no early seizure activity and only mild developmental delay at 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arrest","url":"https://www.academia.edu/Documents/in/Heart_arrest"},{"id":3842849,"name":"Meconium Aspiration Syndrome","url":"https://www.academia.edu/Documents/in/Meconium_Aspiration_Syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="61229316"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/61229316/Nucleated_red_blood_cell_counts_not_associated_with_brain_injury_or_outcome"><img alt="Research paper thumbnail of Nucleated red blood cell counts: not associated with brain injury or outcome" class="work-thumbnail" src="https://attachments.academia-assets.com/74333088/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229316/Nucleated_red_blood_cell_counts_not_associated_with_brain_injury_or_outcome">Nucleated red blood cell counts: not associated with brain injury or outcome</a></div><div class="wp-workCard_item"><span>Pediatric neurology</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective was to determine whether an elevated nucleated red blood cell count at birth after ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective was to determine whether an elevated nucleated red blood cell count at birth after perinatal depression is associated with brain injury as measured by (1) proton magnetic resonance spectroscopy and (2) abnormal neurodevelopmental outcome at 30 months of age. The nucleated red blood cell counts from the first 24 hours of life were statistically analyzed in 33 term infants enrolled in a prospective study of the value of magnetic resonance imaging for the determination of neurodevelopmental outcome after perinatal depression. Nucleated red blood cell counts were elevated in 13/33 (39%). Abnormal outcome (19/33, 54%) was associated with Score for Neonatal Acute Physiology-Perinatal Extension (P = 0.04), decreased N-acetylaspartate to choline ratio in the basal ganglia (P = 0.009), and increased lactate to choline ratio in the basal ganglia (P = 0.02), but not with cord pH, Apgar score, or nucleated red blood cell value. In a logistic regression model, increasing nucleated ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb21518c78963f8d35abf107d80a576d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333088,"asset_id":61229316,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333088/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229316"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229316"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229316; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229316]").text(description); $(".js-view-count[data-work-id=61229316]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229316; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229316']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229316, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb21518c78963f8d35abf107d80a576d" } } $('.js-work-strip[data-work-id=61229316]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229316,"title":"Nucleated red blood cell counts: not associated with brain injury or outcome","translated_title":"","metadata":{"abstract":"The objective was to determine whether an elevated nucleated red blood cell count at birth after perinatal depression is associated with brain injury as measured by (1) proton magnetic resonance spectroscopy and (2) abnormal neurodevelopmental outcome at 30 months of age. 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class="work-thumbnail" src="https://attachments.academia-assets.com/74333023/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/61229315/NR2B_Phosphorylation_at_Tyrosine_1472_Contributes_to_Brain_Injury_in_a_Rodent_Model_of_Neonatal_Hypoxia_Ischemia">NR2B Phosphorylation at Tyrosine 1472 Contributes to Brain Injury in a Rodent Model of Neonatal Hypoxia-Ischemia</a></div><div class="wp-workCard_item"><span>Stroke</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphory...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. Although Y1472 phosphorylation is important for synaptic plasticity, it is unknown whether it is involved in NMDA receptor–mediated excitotoxicity in neonatal brain hypoxia-ischemia (HI). This study was designed to elucidate the specific role of Y1472 phosphorylation of NR2B in neonatal HI in vivo and in NMDA-mediated neuronal death in vitro. Methods— Neonatal mice with a knockin mutation of Y1472 to phenylalanine (YF-KI) and their wild-type littermates were subjected to HI using the Vannucci model. Brains were scored 5 days later for damage using cresyl violet and iron staining. Western blotting and immunoprecipitation were performed to determine NR2B tyrosine phosphorylation. Expression of NADPH oxidase subunits and superoxide production were measured in vivo. NMDA-induced calcium res...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c53a3754a82448aefd5d9ca469644861" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":74333023,"asset_id":61229315,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/74333023/download_file?st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjY2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="61229315"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="61229315"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61229315; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61229315]").text(description); $(".js-view-count[data-work-id=61229315]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61229315; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='61229315']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 61229315, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c53a3754a82448aefd5d9ca469644861" } } $('.js-work-strip[data-work-id=61229315]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":61229315,"title":"NR2B Phosphorylation at Tyrosine 1472 Contributes to Brain Injury in a Rodent Model of Neonatal Hypoxia-Ischemia","translated_title":"","metadata":{"abstract":"Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. Although Y1472 phosphorylation is important for synaptic plasticity, it is unknown whether it is involved in NMDA receptor–mediated excitotoxicity in neonatal brain hypoxia-ischemia (HI). This study was designed to elucidate the specific role of Y1472 phosphorylation of NR2B in neonatal HI in vivo and in NMDA-mediated neuronal death in vitro. Methods— Neonatal mice with a knockin mutation of Y1472 to phenylalanine (YF-KI) and their wild-type littermates were subjected to HI using the Vannucci model. Brains were scored 5 days later for damage using cresyl violet and iron staining. Western blotting and immunoprecipitation were performed to determine NR2B tyrosine phosphorylation. Expression of NADPH oxidase subunits and superoxide production were measured in vivo. NMDA-induced calcium res...","publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Stroke"},"translated_abstract":"Background and Purpose— The NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. Although Y1472 phosphorylation is important for synaptic plasticity, it is unknown whether it is involved in NMDA receptor–mediated excitotoxicity in neonatal brain hypoxia-ischemia (HI). This study was designed to elucidate the specific role of Y1472 phosphorylation of NR2B in neonatal HI in vivo and in NMDA-mediated neuronal death in vitro. Methods— Neonatal mice with a knockin mutation of Y1472 to phenylalanine (YF-KI) and their wild-type littermates were subjected to HI using the Vannucci model. Brains were scored 5 days later for damage using cresyl violet and iron staining. Western blotting and immunoprecipitation were performed to determine NR2B tyrosine phosphorylation. Expression of NADPH oxidase subunits and superoxide production were measured in vivo. 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