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title="Home">Home</a> </li> <li class="breadcrumbs__item"> <a class="breadcrumbs__link" title="Departments & Services" href="/services">Departments & Services</a> </li> <li class="breadcrumbs__item"> <a class="breadcrumbs__link" title="Neurosurgery" href="/neurosurgery">Neurosurgery</a> </li> <li class="breadcrumbs__item">Research</li> </ul> <a class="breadcrumbs__back-link" title=" Neurosurgery" href="/neurosurgery">Back to Neurosurgery</a> </div> </div> </div> </div> </div> </div> <div class="container-fluid iw_section" id="sectionj2veiogk"> <div class="row iw_row iw_container" id="rowj2veiogl"> <div class="iw_columns col-lg-12" id="colj2veiogm"> <div class="row iw_row" id="rowj2veiogo"> <div class="iw_columns col-lg-9 content-has-sidebar" id="colj2veiogq"> <div class="iw_component" id="iw_comp1495171520087"> <style>#iw_comp1495171520087{}</style><span id="skipContent"></span><h1 class="page-title">Neurosurgery Research </h1> </div> <div class="iw_placeholder" id="iw_placeholder1496845733721"> <div class="iw_component" id="iw_comp1531740563844"> <style>#iw_comp1531740563844{}</style><div class="rich-text component " style="" id="" ><span><p>The Department of Neurosurgery at Brigham and Women's Hospital is on the forefront of neuroscience and tumor biology research. With a robust research agenda and state-of-the-art technologies, our program is supported by over 20 research faculty and $10 million in funding each year.</p> <p>Our laboratories conduct both basic science and clinical research to explore a range of complex neurological diseases, such as brain tumors, spinal disorders, stroke, and epilepsy. The aim of our research is to investigate the underlying risks, treatment strategies, and outcomes associated with these diseases and translate new findings to design and optimize neurosurgical treatments for each of our patients. Our Department works collaboratively on various research projects, as well as with other local, national and international partnering institutes.</p></span></div> </div> </div> <div class="iw_placeholder" id="iw_placeholder1495171520092"></div> <div class="row iw_row" id="rowj2veioh2"> <div class="iw_columns col-lg-6" id="colj2veioh3"> <div class="iw_placeholder" id="iw_placeholder1495171520094"></div> </div> <div class="iw_columns col-lg-6" id="colj2veioh4"> <div class="iw_placeholder" id="iw_placeholder1495171520095"></div> </div> </div> <div class="iw_placeholder" id="iw_placeholder1495171520096"> <div class="iw_component" id="iw_comp1531740563845"> <style>#iw_comp1531740563845{}</style><style>#iw_comp1531740563845{}</style><section title="Physician Bios" role="region" class="physician-bio col-1-2-2"> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Nathalie Agar, PhD" src="/assets/BWH/neurosurgery/images/agar_nathalie.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Nathalie Agar, PhD</h3> <p class="physician-bio__title">Focus: Molecular diagnosis and prognosis for clinical and surgical applications</p> </div> <p class="physician-bio__desc"><a href="https://agarlab.bwh.harvard.edu/" target="_blank" rel="noopener noreferrer">Surgical Molecular Imaging Laboratory</a></p> <a class="physician-bio__learn-more" title="See Nathalie Agar, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/42626" target="_blank">See Research Profile <span class="screen-read-text">See Nathalie Agar, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Omar Arnaout, MD" src="/assets/BWH/neurosurgery/images/arnaout_omar.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Omar Arnaout, MD</h3> </div> <p class="physician-bio__desc"><a title="CNOC" href="/neurosurgery/research/computational-neuroscience-outcomes-center" rel="noopener noreferrer">Computational Neuroscience Outcomes Center</a></p> <a class="physician-bio__learn-more" title="See Omar Arnaout, MD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/152080" target="_blank">See Research Profile <span class="screen-read-text">See Omar Arnaout, MD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Fengfeng Bei, PhD" src="/assets/BWH/neurosurgery/images/bei_fengfeng.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Fengfeng Bei, PhD</h3> <p class="physician-bio__title">Focus: Re-wiring of neural circuits</p> </div> <p class="physician-bio__desc"><a title="Bei Laboratory" href="https://bei.bwh.harvard.edu/" target="_blank" rel="noopener noreferrer">Bei Laboratory</a></p> <a class="physician-bio__learn-more" title="See Fengfeng Bei, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/59962" target="_blank">See Research Profile <span class="screen-read-text">See Fengfeng Bei, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Wenya Linda Bi, MD, PhD" src="/assets/BWH/neurosurgery/images/bi_wenya.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Wenya Linda Bi, MD, PhD</h3> <p class="physician-bio__title">Focus: Translational biology of skull base tumors by integrating genomic, immunology, advanced imaging, and computational tools to improve patient and surgical outcomes</p> </div> <p class="physician-bio__desc"><a href="https://skullbase.bwh.harvard.edu/" target="_blank" rel="noopener">Bi Lab</a></p> <a class="physician-bio__learn-more" title="See Wenya Linda Bi, MD, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/91219" target="_blank">See Research Profile <span class="screen-read-text">See Wenya Linda Bi, MD, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="E. Antonio Chiocca, MD, PhD" src="/assets/BWH/neurosurgery/images/chiocca_e-antonio.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">E. Antonio Chiocca, MD, PhD</h3> <p class="physician-bio__title">Focus: Novel experimental therapies for malignant brain tumors</p> </div> <p class="physician-bio__desc"><a href="/neurosurgery/research/labs-and-bios/e-antonio-chiocca-md-phd-lab-and-research">Chiocca Laboratory</a></p> <a class="physician-bio__learn-more" title="See E. Antonio Chiocca, MD, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/53734" target="_blank">See Research Profile <span class="screen-read-text">See E. Antonio Chiocca, MD, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Choi-Fong Cho, PhD" src="/assets/BWH/neurosurgery/images/cho_choi-fong.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Choi-Fong Cho, PhD</h3> <p class="physician-bio__title">Focus: Drug delivery and the blood brain barrier in brain tumors </p> </div> <a class="physician-bio__learn-more" title="See Choi-Fong Cho, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/124482" target="_blank">See Research Profile <span class="screen-read-text">See Choi-Fong Cho, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Elizabeth Claus, MD, PhD" src="/assets/BWH/neurosurgery/images/claus_elizabeth.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Elizabeth Claus, MD, PhD</h3> <p class="physician-bio__title">Focus: Cancer epidemiology and statistical genetics</p> </div> <p class="physician-bio__desc"><a title="Neuro-Epidemiology Laboratory" href="/neurosurgery/research/labs-and-bios/neuro-epidemiology-elizabeth-claus-md-phd">Neuro-Epidemiology Laboratory</a></p> <a class="physician-bio__learn-more" title="See Elizabeth Claus, MD, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/50600" target="_blank">See Researcher Profile <span class="screen-read-text">See Elizabeth Claus, MD, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Rose Du, MD, PhD" src="/assets/BWH/neurosurgery/images/du_rose.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Rose Du, MD, PhD</h3> <p class="physician-bio__title">Focus: Role of genetics in stroke and cerebrovascular diseases</p> </div> <p class="physician-bio__desc"><a title="Cerebrovascular Laboratory " href="/neurosurgery/research/labs-and-bios/cerebrovascular-laboratory-rose-du-md-phd">Cerebrovascular Laboratory</a></p> <a class="physician-bio__learn-more" title="See Rose Du, MD, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/40945" target="_blank">See Research Profile <span class="screen-read-text">See Rose Du, MD, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Alexandra Golby, MD" src="/assets/BWH/neurosurgery/images/golby_alexandra.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Alexandra Golby, MD</h3> <p class="physician-bio__title">Focus: Structural and functional MRI and brain electrophysiology</p> </div> <p class="physician-bio__desc"><a href="https://golbylab.bwh.harvard.edu/" target="_blank" rel="noopener noreferrer">Surgical Brain Mapping Laboratory</a></p> <a class="physician-bio__learn-more" title="See Alexandra Golby, MD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/59505" target="_blank">See Research Profile <span class="screen-read-text">See Alexandra Golby, MD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="William Gormley, MD, MPH, MBA" src="/assets/BWH/neurosurgery/images/gormley_william.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">William Gormley, MD, MPH, MBA </h3> <p class="physician-bio__title">Focus: To harness the administrative, clinical, research and financial data streams combined with detailed outcomes tracking to inform best practices and protocols for neurosurgery.</p> </div> <p class="physician-bio__desc"><a title="CNOC" href="/neurosurgery/research/computational-neuroscience-outcomes-center" rel="noopener noreferrer">Computational Neuroscience Outcomes Center</a></p> <a class="physician-bio__learn-more" title="See William Gormley, MD, MPH, MBA, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/12522" target="_blank">See Research Profile <span class="screen-read-text">See William Gormley, MD, MPH, MBA, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Yi Lu, MD, PhD" src="/assets/BWH/neurosurgery/images/lu_yi.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Yi Lu, MD, PhD</h3> <p class="physician-bio__title">Focus: Functional recovery after spinal cord injury</p> </div> <p class="physician-bio__desc">Spinal Cord Injury Research Laboratory</p> <a class="physician-bio__learn-more" title="See Yi Lu, MD, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/21390" target="_blank">See Research Profile <span class="screen-read-text">See Yi Lu, MD, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Marco Mineo, PhD" src="/assets/BWH/neurosurgery/images/mineo_marco.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Marco Mineo, PhD</h3> <p class="physician-bio__title">Focus: Immunotherapy and non-coding RNAs in brain tumors</p> </div> <a class="physician-bio__learn-more" title="See Dr. Mineo's Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/120304" target="_blank">See Research Profile <span class="screen-read-text">See Dr. Mineo's Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Hiroshi Nakashima, PhD" src="/assets/BWH/neurosurgery/images/nakashima_hiroshi.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Hiroshi Nakashima, PhD</h3> <p class="physician-bio__title">Focus: Oncolytic viruses and immunotherapy in glioblastoma </p> </div> <a class="physician-bio__learn-more" title="See Hiroshi Nakashima, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/112954" target="_blank">See Research Profile <span class="screen-read-text">See Hiroshi Nakashima, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Pier Paolo Peruzzi, MD, PhD" src="/assets/BWH/neurosurgery/images/peruzzi_pier-paolo.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Pier Paolo Peruzzi, MD, PhD</h3> <p class="physician-bio__title">Focus: The biology of small non-coding RNAs and the pioneering of their genetic engineering for a cure against brain cancer. </p> </div> <a class="physician-bio__learn-more" title="See Pier Paolo Peruzzi, MD, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/142243" target="_blank">See Research Profile <span class="screen-read-text">See Pier Paolo Peruzzi, MD, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Image of a caduceus (no photo available)" src="/assets/BWH/neurosurgery/images/rolston_john.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">John Rolston, MD, PhD</h3> <p class="physician-bio__title">Focus: Applying neural engineering and neuromodulation to understand the brain and treat neurological and psychiatric diseases</p> </div> <p class="physician-bio__desc"><a href="https://www.rolstonlab.com/" target="_blank" rel="noopener">Mapping & Engineering Neural Dynamics (MEND) Laboratory</a></p> <a class="physician-bio__learn-more" title="" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/207078" target="_blank">See Research Profile <span class="screen-read-text"></span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Khalid Shah, PhD, MS" src="/assets/BWH/neurosurgery/images/shah_khalid.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Khalid Shah, PhD, MS</h3> <p class="physician-bio__title">Focus: Develop and test novel targeted stem cell based therapies for cancer</p> </div> <p class="physician-bio__desc">Vice Chair for Research<br /><br /><a href="http://csti.bwh.harvard.edu/" target="_blank" rel="noopener noreferrer">Center for Stem Cell Therapeutics and Imaging</a></p> <a class="physician-bio__learn-more" title="See Khalid Shah, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/58726" target="_blank">See Research Profile <span class="screen-read-text">See Khalid Shah, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Timothy R. Smith, MD, PhD, MPH" src="/assets/BWH/neurosurgery/images/smith_timothy.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Timothy R. Smith, MD, PhD, MPH</h3> </div> <p class="physician-bio__desc"><a title="CNOC" href="/neurosurgery/research/computational-neuroscience-outcomes-center" rel="noopener noreferrer">Computational Neuroscience Outcomes Center</a></p> <a class="physician-bio__learn-more" title="See Timothy Smith, MD, MPH, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/12858" target="_blank">See Research Profile <span class="screen-read-text">See Timothy Smith, MD, MPH, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Yanmei Tie, PhD" src="/assets/BWH/neurosurgery/images/tie_yanmei.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Yanmei Tie, PhD</h3> <p class="physician-bio__title">Focus: Developing neuroimaging approaches for presurgical brain mapping and investigation of brain function alterations in neurological conditions.</p> </div> <a class="physician-bio__learn-more" title="See Yanmei Tie, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/2081" target="_blank">See Research Profile <span class="screen-read-text">See Yanmei Tie, PhD, Research Profile</span></a> </div> </div> <div class="physician-bio__item col"> <img class="physician-bio__image" alt="Xin Wang, PhD" src="/assets/BWH/neurosurgery/images/wang_xin.jpg"><div class="physician-bio__side"> <div class="physician-bio__upper"> <h3 class="physician-bio__name">Xin Wang, PhD</h3> <p class="physician-bio__title">Focus: Identification of candidate therapeutics for neurodegenerative disorders</p> </div> <p class="physician-bio__desc"><a href="/neurosurgery/research/labs-and-bios/neuroapoptosis-drug-discovery-laboratory-overview">Neuroapoptosis Drug Discovery Laboratory</a></p> <a class="physician-bio__learn-more" title="See Xin Wang, PhD, Research Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/49926" target="_blank">See Research Profile <span class="screen-read-text">See Xin Wang, PhD, Research Profile</span></a> </div> </div> </section> </div> </div> <div class="iw_placeholder" id="iw_placeholder1495171520097"></div> <div class="iw_placeholder" id="iw_placeholder1495171520098"></div> <div class="iw_placeholder" id="iw_placeholder1495171520099"></div> <div class="iw_placeholder" id="iw_placeholder1495171520100"></div> <div class="iw_placeholder" id="iw_placeholder1508806660228"></div> <div class="iw_placeholder" id="iw_placeholder1508806660229"></div> <div class="iw_placeholder" id="iw_placeholder1676475010693"></div> <div class="iw_placeholder" id="iw_placeholder1676475010694"></div> <div class="iw_placeholder" id="iw_placeholder1676475010695"></div> <div class="row iw_row" id="rowj2veioh6"> <div class="iw_columns col-lg-6" id="colj2veioh7"> <div class="iw_placeholder" 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