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.meta-info, .td-footer-container .td_module_mx1 .td-block14-border { background-color: #666666; } .td-footer-container .widget_calendar #today { background-color: transparent; } .td-footer-container::before { background-size: cover; } .td-footer-container::before { opacity: 0.1; } </style> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "item": { "@type": "WebSite", "@id": "https://ecozen.gr/", "name": "Αρχική" } }, { "@type": "ListItem", "position": 2, "item": { "@type": "WebPage", "@id": "https://ecozen.gr/category/special-topics/", "name": "Special Topics" } } ,{ "@type": "ListItem", "position": 3, "item": { "@type": "WebPage", "@id": "https://ecozen.gr/2024/10/stop-stin-exelixi-tou-karkinou-tou-pnevmona-me-therapeia-syndyasmou-farmakon/", "name": "“Στοπ” στην εξέλιξη του καρκίνου του πνεύμονα με θεραπεία συνδυασμού φαρμάκων" } } ] } </script> <link rel="icon" href="https://ecozen.gr/wp-content/uploads/2017/12/cropped-favicon_76x76-32x32.png" sizes="32x32" /> <link rel="icon" href="https://ecozen.gr/wp-content/uploads/2017/12/cropped-favicon_76x76-192x192.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://ecozen.gr/wp-content/uploads/2017/12/cropped-favicon_76x76-180x180.png" /> <meta name="msapplication-TileImage" content="https://ecozen.gr/wp-content/uploads/2017/12/cropped-favicon_76x76-270x270.png" /> <style type="text/css" id="wp-custom-css"> /* Header */ .td-header-container { background-image: url(https://ecozen.gr/wp-content/uploads/2017/12/header.png) !important; background-repeat: no-repeat; background-size: 100% 100%; background-position: center; } .td-header-top-menu, .td-header-wrap .td-top-menu-full { background: none !important; } .td-header-sp-top-menu .top-header-menu > li > a:hover, .td-header-sp-top-menu .top-header-menu > li > a:visited { color: white; text-decoration: underline !important; } 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category-therapeies category-kosmos tag-anakoptetai tag-astheneis tag-exelixi tag-epistimi tag-iatriki tag-karkinos-tou-pnevmona tag-kliniki-meleti tag-nea-therapeia tag-nosos tag-syndyasmos tag-farmaka" itemscope itemtype="https://schema.org/Article"47> <div class="td-post-header td-pb-padding-side"> <div class="entry-crumbs"><span><a title="" class="entry-crumb" href="https://ecozen.gr/">Αρχική</a></span> <i class="td-icon-right td-bread-sep"></i> <span><a title="Προβολή Special Topics" class="entry-crumb" href="https://ecozen.gr/category/special-topics/">Special Topics</a></span> <i class="td-icon-right td-bread-sep td-bred-no-url-last"></i> <span class="td-bred-no-url-last">“Στοπ” στην εξέλιξη του καρκίνου του πνεύμονα με θεραπεία συνδυασμού φαρμάκων</span></div> <ul class="td-category"><li class="entry-category"><a href="https://ecozen.gr/category/special-topics/">Special Topics</a></li><li class="entry-category"><a href="https://ecozen.gr/category/various/">Ειδήσεις</a></li><li 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class="td-social-but-icon"><i class="td-icon-plus td-social-expand-tabs-icon"></i></div> </a></div></div></div> <div class="td-post-content td-pb-padding-side"> <div class="td-post-featured-image"><a href="https://ecozen.gr/wp-content/uploads/2024/10/karkinos-pneumona.jpg" data-caption=""><img width="640" height="417" class="entry-thumb td-modal-image" src="https://ecozen.gr/wp-content/uploads/2024/10/karkinos-pneumona-640x417.jpg" srcset="https://ecozen.gr/wp-content/uploads/2024/10/karkinos-pneumona-640x417.jpg 640w, https://ecozen.gr/wp-content/uploads/2024/10/karkinos-pneumona-300x194.jpg 300w, https://ecozen.gr/wp-content/uploads/2024/10/karkinos-pneumona-644x420.jpg 644w, https://ecozen.gr/wp-content/uploads/2024/10/karkinos-pneumona-681x444.jpg 681w, https://ecozen.gr/wp-content/uploads/2024/10/karkinos-pneumona.jpg 690w" sizes="(max-width: 640px) 100vw, 640px" alt="karkinos pneumona" title="karkinos pneumona"/></a></div> <div class="td-a-rec td-a-rec-id-content_top tdi_2 td_block_template_1"><span class="td-adspot-title">Διαφήμιση</span><script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script async src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script> <script> window.googletag = window.googletag || {cmd: []}; googletag.cmd.push(function() { googletag.defineSlot('/21969919885/ecozen--posts', [300, 250], 'div-gpt-ad-1635149522369-0').addService(googletag.pubads()); googletag.pubads().enableSingleRequest(); googletag.enableServices(); }); </script>  <div id='div-gpt-ad-1635149522369-0' style='min-width: 300px; min-height: 250px;'> <script> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1635149522369-0'); }); </script> </div></div><header class="entry-header" aria-label="Περιεχόμενο"> <p class="mt-0"><strong>Την πορεία εξέλιξης του καρκίνου του πνεύμονα κατάφερε να ανακόψει μία συνδυαστική θεραπεία με φάρμακα για μεγαλύτερο χρονικό διάστημα, δίνοντας ελπίδα στην επιστημονική κοινότητα αλλά και στους ασθενείς που πάσχουν από την επάρατη νόσο! </strong></p> <div class="mute-text my-1">Μετά από παγκόσμια κλινική δοκιμή διαπιστώθηκε ότι η θεραπεία με αμιβανταμάμπη (amivantamab) και λαζερτινίμπη (lazertinib) ανακόπτει την εξέλιξη της νόσου για 23,7 μήνες κατά μέσο όρο.</div> <div class="post-info row wrap start-center"></div> <div class="featured-media">Η επιστημονική κοινότητα χαιρετίζει τα εντυπωσιακά αποτελέσματα μιας παγκόσμιας <strong>κλινικής δοκιμής </strong>που δείχνουν ότι ένας νέος συνδυασμός φαρμάκων σταμάτησε την πρόοδο του <a href="https://ecozen.gr/2024/08/karkinos-tou-pnevmona-klinikes-dokimes-emvoliou-stin-ellada-kai-alles-6-chores-dinoun-elpida-vinteo/" target="_blank" rel="noopener"><strong>καρκίνου του πνεύμονα</strong></a> για περισσότερο από 40% περισσότερο από τη θεραπεία που χρησιμοποιείται σήμερα. Συγκεκριμένα, η παγκόσμια κλινική δοκιμή έδειξε ότι η θεραπεία με <strong>αμιβανταμάμπη </strong>(amivantamab) και <strong>λαζερτινίμπη</strong> (lazertinib) ανακόπτει την εξέλιξη για <strong>23,7 μήνες κατά μέσο όρο.</strong></div> </header> <div class="entry-content"> <p>Ο καρκίνος του πνεύμονα είναι η <strong>κύρια αιτία θανάτου</strong> από καρκίνο παγκοσμίως, προκαλώντας περίπου <strong>1,8 εκατομμύρια θανάτους </strong>κάθε χρόνο. Τα ποσοστά επιβίωσης σε όσους πάσχουν από προχωρημένες μορφές της νόσου, όπου οι όγκοι έχουν εξαπλωθεί, είναι ιδιαίτερα χαμηλά.</p> <p>Η παγκόσμια κλινική δοκιμή έδειξε ότι ο συνδυασμός των δυο φαρμάκων σταματά την εξέλιξη της νόσου για <strong>23,7 μήνες, </strong>κατά μέσο όρο. Η μέση επιβίωση χωρίς εξέλιξη της νόσου σε ασθενείς που λάμβαναν το φάρμακο <strong>οσιμερτινίμπη</strong> (osimertinib)- το σύνηθες φάρμακο για τη θεραπεία προχωρημένου καρκίνου του πνεύμονα ήταν <strong>16,6 μήνες,</strong> σύμφωνα με τη μελέτη.</p> <p><img fetchpriority="high" decoding="async" class="alignnone size-full wp-image-221723" src="https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona.webp" alt="karkinow toy pmeumona" width="1024" height="1024" srcset="https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona.webp 1024w, https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona-300x300.webp 300w, https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona-150x150.webp 150w, https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona-768x768.webp 768w, https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona-420x420.webp 420w, https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona-640x640.webp 640w, https://ecozen.gr/wp-content/uploads/2024/10/karkinow-toy-pmeumona-681x681.webp 681w" sizes="(max-width: 1024px) 100vw, 1024px" /></p> <p>«Η καλύτερη κατανόηση της βιολογίας που ωθεί τους καρκίνους του πνεύμονα έχει συμβάλλει στην ανάπτυξη αυτών των στοχευμένων θεραπειών» δήλωσε ο Μάρτιν Φόρστερ, ογκολόγος στο νοσοκομείο University College και επικεφαλής ερευνητής της κλινικής δοκιμής στο Ηνωμένο Βασίλειο.</p> <p>Στη δοκιμή φάσης 3, στρατολογήθηκαν <strong>1.074 ασθενείς </strong>μεταξύ 2020 και 2022 από το Ηνωμένο Βασίλειο, τις ΗΠΑ, την Αυστραλία, τη Γαλλία, τη Βραζιλία, την Ινδία και την Κίνα. Όλοι οι εθελοντές έπασχαν από μια προχωρημένη μορφή <strong>μη μικροκυτταρικού καρκίνου του πνεύμονα</strong> (NSCLC), την πιο κοινή μορφή της νόσου. Όλοι όσοι συμμετείχαν στην κλινική δοκιμή έφεραν επίσης μια <strong>μετάλλαξη </strong>του γονιδίου του υποδοχέα του επιδερμικού αυξητικού παράγοντα (EGFR), που βρέθηκε στο 1/4 των παγκόσμιων περιπτώσεων καρκίνου του πνεύμονα και περίπου στο 40% των περιπτώσεων στην Ασία. Η μετάλλαξη EGFR είναι πιο συχνή στις γυναίκες παρά στους άνδρες και σε άτομα που δεν έχουν καπνίσει ποτέ ή που κάπνιζαν λίγο.</p> <p>Οι ασθενείς χωρίστηκαν τυχαία σε ομάδες και είτε έλαβαν τον συνδυασμό των δυο φαρμάκων, είτε την συμβατική θεραπεία με οσιμερτινίμπη. Η αμιβανταμάμπη είναι ένα μονοκλωνικό αντίσωμα ενώ η λαζερτινίμπη είναι ένας αναστολέας της τυροσινικής κινάσης. Και τα δύο φάρμακα στοχεύουν στα καρκινικά κύτταρα προκειμένου να σταματήσουν την εξέλιξή τους.</p> <p>Τον Αύγουστο, η Υπηρεσία Τροφίμων και Φαρμάκων των ΗΠΑ ενέκρινε τον συνδυασμό φαρμάκων. 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