CINXE.COM

Just a moment...

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.science.org",cType: 'managed',cRay: '8e9122269f0c5fce',cH: 'Jxd.GJnSZQeN6INHjeomCxtqQTgzroxaXTf2EwPb38w-1732700181-1.2.1.1-xuLF_p8_HnGciKcDXdWiNeahyllmXVfKytAlzh7tVLnlZJGq0AIPb7s9DxpjzakP',cUPMDTk: "\/doi\/10.1126\/science.2841759?__cf_chl_tk=zre21r_QLheQy0FaEc10w_IVYg9lnCBQGO2Dsqj4gaM-1732700181-1.0.1.1-FhuSRdDqikD6AH397A7QEr7Xs9PTgaJZFqzkPvJ9P4c",cFPWv: 'b',cITimeS: '1732700181',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1126\/science.2841759?__cf_chl_f_tk=zre21r_QLheQy0FaEc10w_IVYg9lnCBQGO2Dsqj4gaM-1732700181-1.0.1.1-FhuSRdDqikD6AH397A7QEr7Xs9PTgaJZFqzkPvJ9P4c",md: "NqrlI9UuBgRkfmgpN63VRLlMghA9zDitxapXYzOZtu4-1732700181-1.2.1.1-.tv619X1uwjcMnlXJ9EKJUUVpmAMtGafzuryoaRZEkrAzwmnTeasEQhaHqRW3dQxMnIkuRguUqH0vpfI4mzl.g5FsYjdvBuiLcnx5..L_v7YQm8T.V3Ic73oFnSVekUEHsNtnQcVgkNJ8V9U_3Z9ajZVRhwQ0ai.zboqBtIXbA2aWoSMzrgEIXf4xYqDUyPRbH21V3mNCsDY3PrkB_IMNoe_4XJ3ZmnU7rhQretIwzp0WCK2LY0OpHz69JzKHf1zo9EU.yKBJNpaKSQh6XJMKJ3JPbaD76BOx9ClBDlBx6JGpniCvb1dqKTMg_vjG3x7_M7fq8t1J2D_2VuBXIjSijxO4lcX5fTAD_nw._DGxpu2Cq0Q6cIxhHcwzaKO5ZwzLo6cVCdBMubJzVFfhRwSezRyx6faIGJ8dIP3xlA6UCqLZMwhAktNwrlkcMEI7f1FUnkTnkGpb7mZLtsikDeRIIyuJPVqZmdm8N1qxNCZXu0IduxDvcADepmJZ4n9T46OHfzWjO8qV1li9wsdvvjUtALFK3P1ecUy_FlNc_lw5k_8crUw.GU3Jy8JTR1UuTVSUE1V5rrTaYTNB4v_2fOF2z5qxOou8uB_w3doqKf11k7ZaszwuBFfBmhdeytVxw5URIGiclbkFljOciKVoUZF9j9I.HcZtP5F74eCgtcxbjMDWs.DKkreisxGf1VxpUSbwSMOtc3iLlVqm638CSmxk_6HsCFlPQ6y4pt1M2B0Jwf_v7skNm9WOia7Dra7zy4hJA9ergUOYOKlKaboDgK.B06RsbG2U6Nxcv41M5GhsTPkanPtrLW0Yo3FlzA63mbLUwJlQT950ypJMfLLnVrC8NEjJ7R6toaC9Hd51wBfgzpFULcXuTyYuMwFBqniQ.ePGu4Bccaf7OaKN.ePRgqJwutyYZ273A6u_CG79cCr.wDsTGYHZAdPvbpdEidLhkHu4kKO2RcAhV4P_C.Wh4Ebw4HSpu0uL46zonEC2vOGyE6biU3t4_A4c.6BTuVmPdgC4S9YlTwX5yNNrAAQWE0bnaICkq.Q3f4IXqU9o57miShz1xwR6TJkPssXiTlP6Qdn0gdDXi0Izao9QpjveUBW2WN92PHyefttMvMOfg710ZhN5uBAyVAbpzsUksmc7Zfpfcl1gUceBFKjkAqUM14YezM2_AreCvqdbVzpfljpuDZXcE6SEjW2GpIsXWarXlhD_55A8mbtRt6ddlbMp.DnoqVppVXIULcIEqQYYOoQWlZTgcIfDHxOxOw_F.EsWkx.8wziM0j9GCo2XTd4kithnqJGryraRiQj4gSqtLXoCoBNX688JgqLMOl6hFV8.UCwBK4Xy_7HEI2KAIAbRVToZXcW_3E523PTzKYe2MFr.SfqvWXgqpBNZuOCoWu1zORZys8zsSp.UjBi_BaMvey.teZTl7_0uLcOoo.ZQivGx1kqU22w3h9kP5pA.QWt.9TcbL9n6aIWyFsrROM02qwwYBq4u2NoyFHdXAG_McImDynb80QU9erkb9BX4J17W0Tki_G76vOPVwCkjKt_uqoK1feD_k32.ArmByjquYmwpH9RbMO1u62VWmqFDPjrHN3AyTgjgW1fZqw.1c3nU.7ZNq9uZ8LUXG4FAuB7eMRbOZF0nhr_Eo405804NEuSYy_EDaFbK9B60kvJA5Fws1gG_lX6ryvIgeeMxjGvsQSS5m86lMseeBrCjd_HfYnMdjOTYUoxfyZa4ADU8cBcQEV.i8wfCdzcUjUvOA9OUuE4aUk_kWLl2SUgvTtMU25qHKzAhHnSSuZaMbX9mzAC0JT8Z7l7v0zbOTh1oA1fuCt4DYxlfJsgqanP6QIdYvS76HgLtmfNVWm2tUPN4N26EGDXcvqBeYkuJ43dsP4UXtLoYqX4A0F76KOXOmAWZ3BIXDKp1SDpUF4gUZLcja2TlIbCqgrs_DHHVmu0x8D3JOGkvO3oAPaizYA3eHsRSRPQt6R7kmrmF.apkasqwnSSjcdFtA.pU89cfQDaFSFELo8qsWQLnl_8_sJsYwa9zN2n5TMBGPvy4J.1AI59mrHYeApeEONvyeLQyKWS8Sn.jScin50wKQwyJ2F15RaGwMK8WzbrEO1pN4E9OwXtSFB1L8JK32IfPB0TveR5aieUc3D9FGnmbczEk1z3talryu8QF0sVAebYgynADzqheQ8RAU6ItbwtVvUnAH_9Fb9MyeQWUa86.gyXRx.rsybVo.7.2XPhKW5guaoGQBptPXU.YbhTRWrIrZLpOcT1wLlpWNA0D0aQZa4KSBJudfjYK64kjQFhMfy6nwqr5IjmU1AU4ky7SV2B_sGGnfDnMZ1PC7BcpAxu69F1PKwHo5pAJLC0lDW4aXsDSSo6EaOYlPxS.81jd6K4KayEd9eNL7qB_.jqTa6EmP_dxNVoq1ieNItvp.2qqCQMyxfqPKJGvta2072o1ktN5lMy7UxDSNb9DE1MEU8gALTF0S2eJfivAiJeS1SN_gcist4k2Sbkn_EDn8mdrX.b3wBcs1aH5Xna9UGEfHBHz9M7Lqlr64ag0I0WSe0zaz3_ItKKkZ.RrDXi8adrWUfx7qKzVoHAbhzkxrVCxqE6.59Bladn_3DzUqUdsxcKnYFmcvUTL0tLM5dFBOAGiWR4kPkT75Q5t8D69bQnGoAwQOWYIpKJ64jcQWzD63uh02NYyW8hGwrxzt4GDVuTuuPv_4wDLlXaTQ6LX97lPWsxeQx1PQ6yFs3ONJtuZER3Vq5CDxYSPRQSS6bd_yCYHQtLLosVq8qZca_ov51QuvRyVopS14GhbMmZDtfJbIiNdYwxDy.IgyIxNG9q.KYEm7bBJG4qI29OcbLSv7Dsz0QPEbos4ctWfKzgGVzN9S19yGvW3UAea3T9g7IoubpQEU4VZW.ElClXs99gOo4O7VcqWWgvUaPIGieDdEFuufckxYScTI5JBG6JsEyl8rigB.CfgE0gpDI5LpBJarEhYZI",mdrd: "8cXps2wF48_kam68Vs7C6WUvLbgD3FqSe4ock.c78VA-1732700181-1.2.1.1-Q2cDCBePTAyE0dVH.280NyxbFfOwSKabxb7o0A_LTuZUVsU_rr._3lfe.jyrf3nCLHcUSjmM4kJipO.5A6hJtGsefuGFuqZ4AswH.lHTzInktO_q2WsLeot_zbdbnMu8XWjqL5AA2K6KhbMY8gfhNQ5P38_4tM0yX4t9rs9bhsvnUmD3Ge9eCDmuIejdClX9cVD4cM.BZxKYO5jUZwJY0VNXhhHaI.c0vhxtDBbyd0nOWWkyRijUeDhH3bOGf102kQ6OzbdREAKb.8cP4ebA61AWfdmvAFtaLg1JlW.Sszc1EiDbSlAkN2vFW2uZAvE2UGTTbWFLo7L6vztWMx3qGj2FGUlvi0UrIjjM_zs53Mli8HvBN1SEUByMqSmgaelu8MT4mgtY.xOvAlWQtBPzEp4A11fi2qkYkwvD9mDmjSOFJSxXrwNY99qpjRGM_aODJ5fBybvuBTiq0PSfF5VTSSYu4D32PpyHyOoKfYHj39MfXRD4U8rDSrSs_0IQNDyRLMlep3ZjpdeTXCFtk.hMvS62YopoPlNCAD9LfRmkIftesgwMTrEHyBXkumbL6m8jIWDGpDNq1shpg_BPuiZktxgRk42YBXlaIc0UYpMK0sxx6vRzwN5DuCyKvWHGLXxiSObiT17PDg3hMvnbXblIFD4iAK9YKo6iRU93GQftPiZgadypRI.u.V07Ou0Kks7H00vN2zeqC8yc7RVtNGI2ppn1DZCr031GWLWL0lCtDY69_geYHkSpEhi4JvNLNTmgKSRUlxI6zYqJqEWwM9SQH4vMQwTzRSDq8Nm_xXBuL33ih72xJAy5uJ9myB_fLegkpRqM1gB._CWZrnNalbDb25C4x2kqpW4c6b4Gk8YGdBaFS3pTcMLl6QuaYlzQPuHj4_v4jlbtuFqd10saff_sJEXvxfuUwpCbkcA4PehIGq7C3yE_DASNTXEFcLVLJ5wy_mAivs8tehxoWz6AsQzj.Yp_LebdkgA8r895hBBESw_efuC7058ZA0VA80bGuzCi907g3IW8S85bSKn_NmgBr95vJ37m.E0BqJxamkVrdpIke3w86yVkHkwXJMZshljJZv9EGu2AnQzNu7FHNwJ_xU4xaXsnggKPKXESz.vFOyFR9plu7SYWTKUolWkP1KCnR7eWsCTh4Jf4M7TuS3ot8VpN65NPqrOLml2QpG6U3w2qBBBB2shv1b9.5bJUn_3NjC1gvTx6i40PcvFiiUNg4Jf6WS4VzAgROFTF4oXc3wqeNkFFD2mOgWHREXWyHqEQaO6gn.wd_YSDcoWr9jwm2hwy869Zlzv4v4JUU1GaSA6pP2vWu7Y4tdPVhE7O5rL564b6qSg58_MtxAESI7MYzZACPXU3fG6B8ZPzjtQ9R7Q1is0EDdoiV69VLv_6LKTooZGK2XZVssYGIqWVsnCQ53XVEJVJl5v92_rqHmRVUcH_N1GGMlNGAwIj3TMx7l0AxT34RNxSxhSXfq9cGDw6_agTofW20bNOMtOM5SFlCfaHH7H4RJHn4ZCJVYKUjotWM4GsI6en9.FMAi2JS2nFvxcusGsovcCath0SwMUgVVq85rK7z07SElL6jN6XE9yQrJWMgjE1FCsPcahk3jkpowKAop5n.tRegPAxhiANkzeoFX2NO4RdPLpIgp3303V6DN.VJiI_80L.Xz0TSCm7.mo.J7j4jLskpuYOySaGiVSojivX2el9lTRUHp19d7K9hgBun7CFQ_g_bm.CkRHqUxoVMe7BxLCKdDMj5jEejUA7uSam5Q7UoQdKSS3lUiZOqSh_a85UMKYQHq6Nf.xOjZcPhMG.Ysc6XOBkxgfaOvz06ez5nbGKPrSfKOJuMADJxwhD9fh7YXOkEYpJcGABLAEe1cRJb9l9On0JN_616UAMCD1yXZC3BlsHWRexEFcO3.5Smfyym95.JXqL7u1siHiLAP7zmPOR7g9sGYx9WduB9MN4EYc_j771psE8v2KQ"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8e9122269f0c5fce';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1126\/science.2841759?__cf_chl_rt_tk=zre21r_QLheQy0FaEc10w_IVYg9lnCBQGO2Dsqj4gaM-1732700181-1.0.1.1-FhuSRdDqikD6AH397A7QEr7Xs9PTgaJZFqzkPvJ9P4c" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>