CINXE.COM
Just a moment...
<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="120"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "publications.waset.org",cType: 'non-interactive',cRay: '914a3be5be868801',cH: 'u4ukTUTMhzDNsF0larbat0LX15IbxTuKAqgSD1VD6cs-1740009810-1.2.1.1-2DXYBJUPiZI_C2xtkXgFIAfbz4RWycofn6FCf9Rz60UsA..BvkDD1maPC1cPbloD',cUPMDTk: "\/abstracts\/search?q=Down%27s%20syndrome&__cf_chl_tk=wsMT_t4LRISVCAivXBRbPeV55dxslbVLgPA0E0ZGN7I-1740009810-1.0.1.1-CKLneRSInCS7cgZ44AZ92v8vhzAFKk.ec2LeGft1sM8",cFPWv: 'g',cITimeS: '1740009810',cTTimeMs: '1000',cMTimeMs: '120000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "unsupported-browser",fa: "\/abstracts\/search?q=Down%27s%20syndrome&__cf_chl_f_tk=wsMT_t4LRISVCAivXBRbPeV55dxslbVLgPA0E0ZGN7I-1740009810-1.0.1.1-CKLneRSInCS7cgZ44AZ92v8vhzAFKk.ec2LeGft1sM8",md: "Nvazw.YHQVQTXmRt1E5GQcSlyxKlovI96PNLU2HichY-1740009810-1.2.1.1-nZNwqR06KrNoxYtiHqatWzggIsURys6LLLjQl7u05ugsobqiGDLO5S72uMzEcEXV1SBCyMKONFMwQh84JwgxOzygQ3xtb8Dxr582yTsj43vk2zYp69DY9tJ.XIbwdmltvcl3Xp.cTlGB3BRot7LQLpvI6SoABea_pqqPfAdpA2resxXJn6iarMDkeLmPqim00WaPPHFQtFb5hq92JEVmVoiioLhWgDeQHLWV0Mz37I699LM6qhH1JU.beV.aRTv9qa84UzGg2eiDz0osp2UC9A9Ud3Ofslg6mqcapNPHbQaLd7MvE4Y.tNv.oTevCZooF1u3A8bO5zybrhLqJERDukXXtP6WNCXkvGgbbfFsBtemmjATQnmY_9MIrmtARhc41T2cLTdllcnhNAlOabs6ESl4wHYJU2B_hu4ikDTQXu3aNCS0RxSQYufXqMl8V8A0__zUCi.SDWshC0TEq2tzLcN3PeQYXY3cQt8ni6QnyCChyBVUus7mFpESgOpD4SnZoqgXSIfbnwccrPihTiOuQraRLXSBR9vBroPFJdmzgWAVuaVBEmsE85PYTP_FsEGIsmvjTJYi2xWnDsKBNwmoufOOc4wYPGmIYaHnCgKUexUb33i3uz2CF_rfZy2MCwSwX2JYygMvjm5ND7vH3MG17.tJ4WemXj9JbuZHJpbn4mcviqLGD9EECR2Zauu4dVB8.lBTuej_qARDWpgbplWqNNwBZx.O0IiSxVp09Cn6YAdTqxRgUslbLImab8X9w8jmktTw5YwZR33v_GVEeCRHuqb1NKH9n5.jhxYFDkKEQQQVOLMxCQcWVdKa3bEqCDATZIYyKU47MHNXcAYhPMz_FW8uTYEB3I_Z.65xE_zkbhBpOQHdDjc9AI3fRo3K9iGFZZDvTBtdHYsHuJifymhe7A_ndayrxamCtza2HmCyjFq6BFgqKcBf2n3bNqcn_K8W9f8Q4o0n7GDT7EPlTa62WSKSJo59S_8WFry2vErVB9e4FNyIte24uACsgYC3ScW3lBoPpn0RPlu1BL7sTexscI8JVcN5ErJ2knSEN1cAhb6hxpjMax0xu0huMYej8evtfYW0z2eXkGJv5AMjbmr5gJ9IqTpufetM1O_qc_JJU.h3dyFpuE28ljmGy1EHX7cgtLwcwErB0.Z0H6TQdn.8gPZYbq3MLNQRS0SvRXLsLIJGm6sSfOoMZ2HIsHR44TArmSLp33MJkfg_tqtqNzYN_DeBx30KdVbG_VhT5FmJyBuc6BANmnmoj0r2xmCmAFCYh4OdpPE0N99YK02y.s8H5r_EjBJFu98pwRfkFFGcX8hqO9vqvuuVCcc6SjcAqiajuFw.2fl8ingfqcjThYAAYGIdgHS6Ajt8Oa_bz4WWHu3w6cXHNp2ltsL.yO_FicTQr9Typc_kjbrOQ04LMYIwGmr2yLVZ9TVsMHLHx6caX6facoNzVRpSm4X1tJbRMcUxpytxoTQaj1z8YWyW3dF4zQG0rGGfDej9.rW4_xzJywiv3JCxSpLWkJ7aqz5.dGu3CJrrIShk14XhrLlBpdqhD3QkM_lCskE1bMRvqCmxMsPruNuPUUq3uyABgvRp50vZniitwpb11sjBrxA3gli2403VMctW0fQoKYfao8A5cGsSKT.XiPfZ_LkWN8BheuEKaOhte4SU9OG1SNshghjPnXzY3UJQNw1bH6MQ8_Sum8IB5FoL0O8PTwCTsEkCf.sK487pFjvdw6.KDf3w2QDw6SMnLNyZGbEj3GYl2lP6qAYh9xvb1.xomLs7agItkoRr6CMg.dPZwQbVMkxyTvoG51IIyw.jFGHyELjsrmzixuqvZzbm9fAMqw.EXtqX9QZU1ZIDiTzk6ggKpJ3qWCffRvLJ1Q42ByuFlXSjrq7i9oNo6X6UOUmDNqR_lAwtIRh_6UVuxB_WawiBHhKwa7vT8o1K66DZGDbVvtDdTida4.8",mdrd: "aI79Y7RlqsLqS3BTHyDejh53B4oSlFrrpcGYzl7sV.E-1740009810-1.2.1.1-MjoBTSbC9OaH8dz.qerSiWd8JI8T7WAsM1FpT4wbJJ4VHvAWYau3aY6NAR0a7fLWiGRQ_PkE0mHjF8C6nLBuX5zGwVDQetE5fncEVRj8Ifgc59Vxls2FhU6j7zEcjgHyypE54C66I6ne_yA2KnbS_IBNeol6kV2iafgIlDNqdKrx3LYo2gYFtiA7tVVr6gG0zDf.8Jniu_LtXyxq5cZyYR_fJgvTY01KbH5a8KLu5iRPWxLyoS0MyHPMm9HNunsNtp3kd1y6GceALjr7172VE715uUjjFHuiHa7Rf4tcwzdd504EgdEW_qLHogI.QI5HyWCfa_S26wFq_gsiG4kKgC3u7IqnmIV9ELv6.bqPTgeXx1qigNGO8MU2lsvrkuy2bK19eU8tq4QIe1A_wqkWlTIyUwmsyUxTuiaeT15tiaL0p_lW8e5Z1_VJOwbcPNsC5mn3EaQkLL5WOQUHYZC9_49RrsJ8_pM_caDIAxx0z0s7UJTVwqhrCjk4HP0YgySAw2P98P2rJg3cdYk7XHfft5RtD_lNjchNr6unROL7JSEbtoq5yYks7N.XM0u5UM3EVynpUDP.RK1SHkySgQBbfuE5CWeCb8Bu4WJvzzt3GCoeIVcWzzuEJJcXMJJd9EuCqZrL.iGACeNLQefo_7TvYbtJMNgyniv.xwHC0I2G8dTwhPOgcrf7pzrbcv4U6NhZd4LXadhQcD2_pz_Hr2WAFyx0yOQmOA8ALldoBtV_PW74yY7YYsa7qY1agyOf8.BDred._q7ZqHMwIeKBYeFte4lhokQ3r.sv3yLKZK_MRrOFno0s3OmTN0fPCx.9oHSKZe92cbJyKq3UvZhKoKJCYny56n51km.FGwPIwnyrrYfrVSCtVeNS2OxSX0FLWPnp_6QKomn3Cu.0CYt8Wk5M4.2N_YJKddfzQvwqZcV9o5_TKIa5HUxN1NoxCtl9zWJuIcJzhHKZ6akrY9NF8wZQqphAFbACJtW_IJo0kVnlSq7TZLnFMEj1WB5nBG60qTwTGvkhdj719HkrjMfgermT1LvPLW8qoAtGXofGQPVfnN0xCufor9o91T2r1IURfYB1_TzRQDVqI1fLtLjX0EK_vDZaEVYuRKNd9IGZQpU2jFqys9g6jissO9m7jWRH7L_kGXiQmE4hvjQxBq6eJ9jUL4wf3zPxNMqwfW2m7rNRdGjPkgjnOnAmNW73SgrDdau.7tPixpBoKIumh2yUh1D5_4_L8iNjGCPI2rEDL5Cu6YNqDUWshMJXc0PqW_EmhI4Tjr4CSSCmqS8jCqO2VpG8tEbrj9TWJnz6DHh8lFB_GXL9CYAEqZTFm_sbj4rMJZFA5RTEfzTm1kRL4gd1PN1.j1ygx1krDg9x9YmMjrK0_CfPYC3BhQs1D0OoVOMGVZjUsi6GYfYHREovjdiYRGUNaouSJBOisn.2PvoELQqJTJ7kXUwI2cJD9xcx.hY3vLeMfgU9SBfiVSY5bIQrsHYwyY73TsitrCQvWkHXjo.5_3KaSwMVdvvJ_f25mf_sG9e44Op4itiAc_wwYYh3GhgwnZTAn.J5h1qJASu1AYrVBeIpQsLW3ToYtiyvd9F1x1rlfFX.PtGlCh20L7GIjcu2ml2eUv57KC27Haf9Kr4UAXMNLJgSare6F62rDEcz18rvNrm_dmzRSXv4JD_nGQ7C09B4MjMXOtsR4xhFanL1meBVapGPorFuNpZPSaqOclkMIKLiaUJ6DhdbBIouBRz2RcTeQaIRfxos54TWzXhZttYxiwctTphJUexzudVxgEUVXOy9bK8Bcu64T7js_2NOF0MDaFHnFVqJ_m2OvTQKlFK4v157dl2OILUI5YhTMPotQu8qLl4sdRZB5oEC8bh5zRR5t0WVJv4J6OhYx_WMGJBqtxtAhXTS5SSOXjrPTostbbKsYhdx2_f2Ljq1w5KN1mMlHVcWAhkqEfqQ_7PGBvbhLVqes7aBg_LvfRNRg_hy0B2t3twpfZ2TLP6W7Wmirw"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=914a3be5be868801';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/abstracts\/search?q=Down%27s%20syndrome&__cf_chl_rt_tk=wsMT_t4LRISVCAivXBRbPeV55dxslbVLgPA0E0ZGN7I-1740009810-1.0.1.1-CKLneRSInCS7cgZ44AZ92v8vhzAFKk.ec2LeGft1sM8" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>