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We generated high-quality datasets for 81 samples, including single-cell, single-nuclear, spot-level (Visium) and single-cell resolution (CosMx) spatial-RNA expression and single-nuclear open chromatin, capturing cells from healthy, diabetic and hypertensive diseased human kidneys. Combining these data, we identify cell types and map them to their locations within the tissue. Unbiased deconvolution of the spatial data identifies the following four distinct microenvironments: glomerular, immune, tubule and fibrotic. We describe the complex organization of microenvironments in health and disease and find that the fibrotic microenvironment is able to molecularly classify human kidneys and offers an improved prognosis compared to traditional histopathology. We provide a comprehensive spatially resolved molecular roadmap of the human kidney and the fibrotic process, demonstrating the clinical utility of spatial transcriptomics.</p> <p> DOI: 10.1038/s41588-024-01802-x</p> <p> Source: <a href="https://www.nature.com/articles/s41588-024-01802-x">https://www.nature.com/articles/s41588-024-01802-x</a></p> </p> <div class="remarks">期刊信息</div> <div class="dd"><p> <span style="font-weight: bold;">Nature Genetics：</span>《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307<br /> <span style="font-weight: bold;">官方网址：</span><a href="https://www.nature.com/ng/" target="_blank">https://www.nature.com/ng/</a><br /> <span style="font-weight: bold;">投稿链接：</span><a href="https://mts-ng.nature.com/cgi-bin/main.plex" target="_blank">https://mts-ng.nature.com/cgi-bin/main.plex</a></p> </div> </div> </div> <style> #footer{ background:#890f0e; text-align:center; padding:10px; color:#FFF; font-size:12px;} #footer a{color:#FFF; font-size:12px;} </style> <div id="footer"><a href="http://www.sciencenet.cn/aboutus/" target="_blank">关于我们</a> | <a href="http://www.sciencenet.cn/shengming.aspx" target="_blank">网站声明</a> | <a href="http://www.sciencenet.cn/tiaokuang.aspx" target="_blank">服务条款</a> | <a href="http://www.sciencenet.cn/contact.aspx" target="_blank">联系方式</a> | <a href="http://www.sciencenet.cn/RSS.aspx">RSS</a> | <a href="mailto:jubao@stimes.cn">举报</a> | <a href="https://stimes.sciencenet.cn/">中国科学报社</a> <br> <a href="https://beian.miit.gov.cn" target="_blank" > 京ICP备07017567号-12 </a> 互联网新闻信息服务许可证10120230008  京公网安备 11010802032783<br>Copyright @ 2007-<script type="text/javascript">var Date22 = new Date();var year22 = Date22.getFullYear();document.write(year22);</script> 中国科学报社 All Rights Reserved<br> 地址：北京市海淀区中关村南一条乙三号  邮箱：blog@stimes.cn <br> <span style="display:none"> <script type="text/javascript"> var _bdhmProtocol = (("https:" == document.location.protocol) ? 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