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Division of Metabolism and Health Effects (DMHE) | National Institute on Alcohol Abuse and Alcoholism (NIAAA)
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xlink:href="/sites/default/themes/solstice/assets/uswds/img/sprite.svg#search"></use> </svg> </button> </form> </div> </div> </nav> </header> <div class="above-content"> <div> <div class="page-banner"> <div class="l-inner"> <p class="h1 heading-1 text-reverse">Research</p> <p class="text--reverse">The NIAAA is the lead agency for U.S. research on the causes, consequences, prevention and treatment of alcohol use disorder and alcohol-related problems.</p> </div> </div> <div id="block-solstice-breadcrumbs"> <nav role="navigation" aria-label="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <div class="breadcrumb"> <ol class="breadcrumb-list no-bullets"> <li class="breadcrumb-list-item"> <a href="/">Home</a> </li> <li class="breadcrumb-list-item"> <a href="/research">Research</a> </li> <li class="breadcrumb-list-item"> <a href="/extramural-research">Extramural Research</a> </li> <li class="breadcrumb-list-item"> Division of Metabolism and Health Effects (DMHE) </li> </ol> </div> </nav> </div> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> <div class="usa-section"> <div class="main--container"> <div class="grid-row grid-gap"> <main class="main--content" id="main-content"> <div id="block-solstice-content"> <article> <div class="content-river"> <h1> <span>Division of Metabolism and Health Effects (DMHE)</span> </h1> <div><p>The Division of Metabolism and Health Effects (DMHE) develops scientific initiatives and supports basic and translational research on the health consequences of alcohol consumption and metabolism, with the goal of improving human health and well-being. The DMHE supports research on the health effects of alcohol that may result from a single dose, chronic or binge drinking behavior emphasizing metabolic pathways, adduct formation, non-enzymatic metabolism, and various substrates that may be affected by alcohol or alcohol metabolites; identification of molecular pathways by which alcohol causes tissue and organ damage; biomarker development to detect and monitor alcohol-induced pathologies; etiology and progression of medical disorders arising from the use of alcohol; and the use of systems biology, bioinformatics, and real-time imaging methods to uncover biological pathways and networks involved in alcohol metabolism and organ damage across the lifespan.</p> <p>The DMHE encourages multidisciplinary approaches that integrate genetic, molecular, cellular, and animal models to understand mechanisms of alcohol action and injury. Research areas supported by the Division include:</p> <div class="flex-column"> <ul> <li>Alcohol Metabolism and Pharmacokinetics</li> <li>Alcohol-Induced Tissue Damage <ul> <li>Alcohol-associated Liver Disease</li> <li>Alcoholic Pancreatitis</li> <li>Alcohol and the Lung</li> <li>Alcohol and the Cardiovascular System</li> <li>Alcohol and Musculoskeletal Disorders</li> <li>Biomarkers of Alcohol Use and Alcohol-induced Tissue Injury</li> </ul> </li> <li>Fetal Alcohol Spectrum Disorders</li> <li>Alcohol and Cancer</li> </ul> <ul> <li>Alcohol and the Immune System</li> <li>Alcohol and Viral Infections</li> <li>The Role of Mitochondria in Alcohol-induced Pathology</li> <li>Alcohol, Retinoic Acid, and Stem Cells</li> <li>Alcohol and Trauma</li> <li>Genetics, Genomics and Alcohol-induced Tissue Injury</li> <li>Epigenetics: DNA Methylation, Histone Modification, and RNA-mediated Gene Regulation</li> <li>Systems Biology Approaches in Alcohol Research</li> <li>Alcohol and Aging</li> <li>Alcohol and Protein Homeostasis (Proteostasis)</li> </ul> </div></div> <h2></h2> <div class="featured-foa"> <h2>Featured Funding Opportunities</h2> <p>Below are some of our current funding opportunities. Before submitting your application, please reach out to one of our staff members to learn more.</p> <ul class="field-foas"> <li> <div class="paragraph paragraph--type--single-foa-link paragraph--view-mode--default"> <div class="single-foa"> <p> <div> <div><a href="https://grants.nih.gov/grants/guide/pa-files/PAR-24-067.html">PAR-24-067: Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R34 Clinical Trial Optional)</a></div> </div> </p> <p><strong>Open Date</strong>: <time datetime="2024-01-16T12:00:00Z">January 16, 2024</time> </p> <p><strong>Expiration Date</strong>: <time datetime="2027-01-08T12:00:00Z">January 8, 2027</time> </p> </div> </div> </li> <li> <div class="paragraph paragraph--type--single-foa-link paragraph--view-mode--default"> <div class="single-foa"> <p> <div> <div><a href="https://grants.nih.gov/grants/guide/pa-files/PAR-24-068.html">PAR-24-068: Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)</a></div> </div> </p> <p><strong>Open Date</strong>: <time datetime="2024-01-16T12:00:00Z">January 16, 2024</time> </p> <p><strong>Expiration Date</strong>: <time datetime="2026-11-17T12:00:00Z">November 17, 2026</time> </p> </div> </div> </li> <li> <div class="paragraph paragraph--type--single-foa-link paragraph--view-mode--default"> <div class="single-foa"> <p> <div> <div><a href="https://grants.nih.gov/grants/guide/pa-files/PAR-24-071.html">PAR-24-071: Alcohol Research-Related Resource Award (R24 Clinical Trial Not Allowed)</a></div> </div> </p> <p><strong>Open Date</strong>: <time datetime="2023-12-25T12:00:00Z">December 25, 2023</time> </p> <p><strong>Expiration Date</strong>: <time datetime="2026-09-26T12:00:00Z">September 26, 2026</time> </p> </div> </div> </li> </ul> </div> <h2>Consortia and Centers</h2> <div><div> <p>DMHE supports a variety of Alcohol Research Centers and Consortia that investigate organ damage and health outcomes associated with alcohol consumption</p> <ul> <li><a href="http://www.alchepnet.org/">Alcoholic Hepatitis Network (AlcHepNet)</a><br> A network with the goal of transforming the clinical treatment of alcoholic hepatitis by rapidly translating novel and innovative basic science discoveries into clinical practice.</li> <p></p> <li><strong><a href="http://keck.usc.edu/Research/Centers_and_Programs/Research_Center_For_Alcoholic_Liver_and_Pancreatic_Disease.aspx">Southern California Research Center for ALPD and Cirrhosis</a></strong><br> The Alcohol Research Center unifies investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for alcoholic liver and pancreatic diseases (ALPD).</li> <p></p> <li><strong><a href="http://alcoholresearch.lsuhsc.edu/default.aspx">Louisiana State University Health Sciences Center (LSUHSC) New Orleans Comprehensive Alcohol-HIV/AIDS Research Center (CARC)</a></strong><br> The scientific focus of the CARC at the LSUHSC is to conduct cutting edge basic research on alcohol and HIV that can be translated into effective community-based interventions.</li> <p></p> <li><strong><a href="http://cifasd.org/">Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)</a></strong><br> A multidisciplinary consortium of domestic and international projects addressing the prevention of fetal alcohol spectrum disorders (FASD), diagnosis of the full range of birth defects associated with prenatal alcohol exposure, and ameliorative interventions for affected individuals.</li> <p></p> <li><a href="https://keck.usc.edu/alpd-and-cirrhosis-research-center/">Southern California Research Center for ALPD and Cirrhosis </a><br> A consortium focused on understanding the molecular mechanisms underlying the predisposition to advanced alcoholic liver and pancreatic diseases (ALPD).</li> <p></p> <li><strong><a href="https://louisville.edu/arc">University of Louisville Alcohol Research Center (ULARC)</a></strong><br> The ULARC serves as a regional and national resource for the study of nutrition and alcohol-induced organ injury.</li> <p></p> <li><strong><a href="https://www.lerner.ccf.org/alcohol-center/">Northeast Ohio Alcohol Center (NOAC) </a></strong><br> The NOAC focuses on understanding the genetic, molecular, cellular, and physiological responses critical to the development of alcoholic liver disease.</li> <p></p> <li><strong><a href="http://sites.bu.edu/urbanarch/">Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (Urban Arch)</a></strong><br> An international consortium conducting and disseminating interdisciplinary research aimed at understanding how alcohol use impacts people affected by HIV and develops interventions to reduce alcohol use and alcohol and HIV-related consequences in this population.</li> <p></p> <li><strong><a href="http://sharc-research.org/">Southern HIV and Alcohol Research Consortium (SHARC)</a></strong><br> The SHARC seeks to improve health outcomes and reduce HIV transmission among the diverse range of populations affected by alcohol and HIV infection in the Southeastern United States.</li> </ul> </div></div> <h2>Frequently Asked Questions</h2> <div><p><strong>Does your research proposal align with the NIAAA mission?</strong><br> <u>Answer:</u> We advise you to contact a Program Director listed either below or on a particular Notice of Funding Opportunity (NOFO) to discuss your research interests before preparing your application. This will not only help determine whether your proposal is of interest to NIAAA, but will aid in the preparation of your grant application. <span><span><span><span>Before applying, please ensure:1) that basic research questions you are asking are mechanistically and etiologically relevant to human disease; 2) that the animal model and protocol replicate human disease; and 3) that alcohol feeding model addresses physiological alcohol levels and reflects patterns of human consumption.</span></span></span></span></p> <p><strong>Who should I contact within the Division about my research proposal?</strong><br> <u>Answer:</u> Below is a list of Program Directors and their areas of research interests. The best way to contact a Program Director whose interest aligns with your own is via email. Alternatively, if you would like to speak by phone, please indicate this in an email and a Program Director will contact you soon thereafter.</p> <p><strong>What is the process for applying for funding?</strong><br> <u>Answer:</u> When submitting a grant application to NIAAA, extramural researchers can find instructions in the <strong><a href="https://www.niaaa.nih.gov/grant-funding/funding-opportunities">Notice of Funding Opportunity</a> </strong>to which they are applying. See the NIAAA <strong><a href="https://www.niaaa.nih.gov/grant-funding/application-process">application process homepage</a> </strong>for information about grant applications, the peer review process, and understanding how applications are selected for funding.</p></div> <h2>Our Staff</h2> <div > <table class="full staff-list"> <thead> <tr> <th scope="col" class="name">Name</th> <th scope="col" class="position">Position</th> <th scope="col" class="focus-area">Focus Area<sup>*</sup></th> </tr> </thead> <tbody> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/kathy-jung-phd" rel="bookmark"> <span>Kathy Jung, Ph.D.</span> </a></td> <td class="job-title"> <div>Division Director</div> </td> <td class="focus-area"> <div> Alcohol-induced organ injury and effects of alcohol on organ-organ interactions and immune function; alcohol biomarkers; microbiome; wearable alcohol biosensors </div> </td> </tr> </article> </div> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/bill-dunty-phd" rel="bookmark"> <span>Bill Dunty, Ph.D.</span> </a></td> <td class="job-title"> <div>Program Director</div> </td> <td class="focus-area"> <div> Alcohol-associated carcinogenesis; Animal models of fetal alcohol spectrum disorders (FASD); Basic and clinical research on the consequences of prenatal alcohol exposure; Cell Biology; Fetal Alcohol Spectrum Disorder (FASD) </div> </td> </tr> </article> </div> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/peter-gao-md" rel="bookmark"> <span>Peter Gao, MD</span> </a></td> <td class="job-title"> <div>Program Director</div> </td> <td class="focus-area"> <div> Aging; Alcohol-associated Liver Disease; clinical studies on alcohol abuse and alcoholism; pancreatitis; regenerative medicine </div> </td> </tr> </article> </div> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/li-lin-phd" rel="bookmark"> <span>Li Lin, Ph.D.</span> </a></td> <td class="job-title"> <div>Program Director</div> </td> <td class="focus-area"> <div> Aging; Alcohol-associated Liver Disease; cardiovascular disease; Immune function; alcohol-induced organ injury; Immunology; lung and vascular functions; translational research </div> </td> </tr> </article> </div> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/gary-murray-phd" rel="bookmark"> <span>Gary Murray, Ph.D.</span> </a></td> <td class="job-title"> <div>Program Director</div> </td> <td class="focus-area"> <div> Alcohol and cancer; Alcohol-associated Liver Disease; Biochemistry; enzymology; kinetics; lipid metabolism; metabolism; mitochondrial diseases; pancreatitis; wearable alcohol biosensors </div> </td> </tr> </article> </div> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/liz-perruccio-ms-phd" rel="bookmark"> <span>Liz Perruccio, M.S., Ph.D.</span> </a></td> <td class="job-title"> <div>Program Director</div> </td> <td class="focus-area"> <div> Alcohol-associated carcinogenesis; Cell Biology; epigenetics; Extracellular matrix; Gut-Brain axis; liver pathology and fibrogenesis </div> </td> </tr> </article> </div> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/svetlana-radaeva-phd" rel="bookmark"> <span>Svetlana Radaeva, Ph.D.</span> </a></td> <td class="job-title"> <div>Program Director</div> </td> <td class="focus-area"> <div> Alcohol-associated Liver Disease; hepatocarcinogenesis; liver pathology and fibrogenesis; oval cell proliferation; tissue repair and regeneration </div> </td> </tr> </article> </div> <div> <article> <tr> <td class="staff-name"><a href="/about-niaaa/our-staff/h-joe-wang-phd" rel="bookmark"> <span>H. 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