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значајних жена\u003C/a\u003E\u003C/b\u003E на Викицитату.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\n\u003Cdiv class=\"noticebanner\"\u003E\u003Cdiv class=\"plainlinks\" style=\"background-color: #FBEBEA; border-radius:5px; margin-top:10px; position:relative; border: 1px solid #aaa; font-family: \u0026#39;Helvetica\u0026#39;, \u0026#39;Arial\u0026#39;, sans-serif; line-height: 18px; box-shadow: 0 1px 1px rgba( 0, 0, 0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; font-size:25px; line-height:25px\"\u003E\u003Cdiv style=\"padding-left:50px;\"\u003E\u003C/div\u003E\u003C/div\u003E\u003Cdiv style=\"padding-top:2px; color:#444; font-size:1.15em; line-height:1.5;\"\u003E\u003Cdiv style=\"padding-left:8px; padding-right:8px;\"\u003EПридружите се \u003Cb\u003E\u003Ca href=\"/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%90%D0%BA%D1%86%D0%B8%D1%98%D0%B0_%D0%BF%D1%80%D0%BE%D1%88%D0%B8%D1%80%D0%B8%D0%B2%D0%B0%D1%9A%D0%B0_%D0%BA%D0%BB%D0%B8%D1%86%D0%B0\" title=\"Википедија:Акција проширивања клица\"\u003Eакцији проширивања клица\u003C/a\u003E\u003C/b\u003E.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E";}}());</script></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Сајт"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Садржај" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Садржај</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">сакриј</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Почетак</div> </a> </li> <li id="toc-Tahikininski_receptor_1" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Tahikininski_receptor_1"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Tahikininski receptor 1</span> </div> </a> <ul id="toc-Tahikininski_receptor_1-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Otkrivanje_i_razvoj_lekova" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Otkrivanje_i_razvoj_lekova"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Otkrivanje i razvoj lekova</span> </div> </a> <button aria-controls="toc-Otkrivanje_i_razvoj_lekova-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Садржај одељка Otkrivanje i razvoj lekova</span> </button> <ul id="toc-Otkrivanje_i_razvoj_lekova-sublist" class="vector-toc-list"> <li id="toc-Razvoj_prvog_leka" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Razvoj_prvog_leka"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Razvoj prvog leka</span> </div> </a> <ul id="toc-Razvoj_prvog_leka-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Druga_jedinjenja" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Druga_jedinjenja"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Druga jedinjenja</span> </div> </a> <ul id="toc-Druga_jedinjenja-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vezivanje" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Vezivanje"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>Vezivanje</span> </div> </a> <ul id="toc-Vezivanje-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Spoljašnje veze</span> </div> </a> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Садржај" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Прикажи/сакриј садржај" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Прикажи/сакриј садржај</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Antagonisti NK1 receptora</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" 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Доступан на: 4" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-4" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">4 језика</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D9%86%D8%A7%D9%87%D8%B6%D8%A7%D8%AA_%D9%85%D8%B3%D8%AA%D9%82%D8%A8%D9%84%D8%A7%D8%AA_%D8%A5%D9%86_%D9%83%D9%8A1" title="مناهضات مستقبلات إن كي1 — арапски" lang="ar" hreflang="ar" data-title="مناهضات مستقبلات إن كي1" data-language-autonym="العربية" data-language-local-name="арапски" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/NK1_receptor_antagonist" title="NK1 receptor antagonist — енглески" lang="en" hreflang="en" data-title="NK1 receptor antagonist" data-language-autonym="English" data-language-local-name="енглески" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Antagoniste_des_r%C3%A9cepteurs_NK1" title="Antagoniste des récepteurs NK1 — француски" lang="fr" hreflang="fr" data-title="Antagoniste des récepteurs NK1" data-language-autonym="Français" data-language-local-name="француски" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Antagonisti_NK1_receptora" title="Antagonisti NK1 receptora — српскохрватски" lang="sh" 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id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sr" dir="ltr"><p><b>Neurokinin 1 (NK<sub>1</sub>) antagonisti</b> su klasa lekova koja poseduje jedinstvena <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D0%B4%D0%B5%D0%BF%D1%80%D0%B5%D1%81%D0%B0%D0%BD%D1%82" class="mw-redirect" title="Антидепресант">antidepresantska</a>,<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Anksiolitik" title="Anksiolitik">anksiolitička</a>,<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> i <a href="/wiki/Antiemetici" class="mw-redirect" title="Antiemetici">antiemetička</a> svojstva. Otkriće antagonista <a href="/wiki/Neurokinin" class="mw-redirect" title="Neurokinin">neurokininskog 1</a> (<a href="/wiki/Tahikininski_receptor_1" title="Tahikininski receptor 1">NK<sub>1</sub></a>) receptora je bila prekretna tačka u prevenciji mučnine i povraćanja vezane za <a href="/wiki/Hemoterapija" title="Hemoterapija">hemoterapiju</a> raka.<sup id="cite_ref-Hesketh_2004_3-0" class="reference"><a href="#cite_note-Hesketh_2004-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>Jedan primer leka iz ove klase je <a href="/wiki/Aprepitant" title="Aprepitant">aprepitant</a>. Hemoterapijom uzrokovana <a href="/wiki/%D0%9F%D0%BE%D0%B2%D1%80%D0%B0%D1%9B%D0%B0%D1%9A%D0%B5" title="Повраћање">emesis</a> se sastoji od akutne i kasnije faze. Povraćanje akutne faze se može tretirati <a href="/wiki/5-HT3_antagonist" title="5-HT3 antagonist">5-HT<sub>3</sub> antagonistima</a>, dok se kasnija faza teško kontroliše. Antagonisti NK<sub>1</sub> receptora utiču na obe faze, a posebno na kasniju fazu.<sup id="cite_ref-Watanabe_2008_4-0" class="reference"><a href="#cite_note-Watanabe_2008-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>Prva registrovana klinička upotreba antagonista NK<sub>1</sub> receptora je bila za emesis tretman, uzrokovan <a href="/wiki/Hemoterapija" title="Hemoterapija">hemoterapijom</a>.<sup id="cite_ref-Brain_2006_5-0" class="reference"><a href="#cite_note-Brain_2006-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Tahikininski_receptor_1">Tahikininski receptor 1</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonisti_NK1_receptora&veaction=edit&section=1" title="Уредите одељак „Tahikininski receptor 1”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonisti_NK1_receptora&action=edit&section=1" title="Уреди извор одељка: Tahikininski receptor 1"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r24414138">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}</style><div role="note" class="hatnote navigation-not-searchable">Glavni članak: <a href="/wiki/Tahikininski_receptor_1" title="Tahikininski receptor 1">Tahikininski receptor 1</a></div> <p>Tahikinini su familija <a href="/wiki/Neuropeptid" class="mw-redirect" title="Neuropeptid">neuropeptida</a> koji imaju zajednički <a href="/wiki/Hidrofobnost" class="mw-redirect" title="Hidrofobnost">hidrofobni</a> <a href="/wiki/C-terminus" title="C-terminus">C-terminalni</a> region sa <a href="/wiki/%D0%90%D0%BC%D0%B8%D0%BD%D0%BE%D0%BA%D0%B8%D1%81%D0%B5%D0%BB%D0%B8%D0%BD%D0%B0" title="Аминокиселина">aminokiselinskom</a> sekvencom <a href="/wiki/%D0%A4%D0%B5%D0%BD%D0%B8%D0%BB%D0%B0%D0%BB%D0%B0%D0%BD%D0%B8%D0%BD" title="Фенилаланин">Phe</a>-X-<a href="/wiki/%D0%93%D0%BB%D0%B8%D1%86%D0%B8%D0%BD" title="Глицин">Gly</a>-<a href="/wiki/Leucin" title="Leucin">Leu</a>-<a href="/wiki/%D0%9C%D0%B5%D1%82%D0%B8%D0%BE%D0%BD%D0%B8%D0%BD" title="Метионин">Met</a>-NH<sub>2</sub>, gde X predstavlja <a href="/wiki/Hidrofobnost" class="mw-redirect" title="Hidrofobnost">hidrofobni</a> ostatak koji je bilo <a href="/wiki/Aromati%C4%8Dnost" class="mw-redirect" title="Aromatičnost">aromatičan</a> ili beta-razgranati <a href="/wiki/Alifati%C4%8Dno_jedinjenje" title="Alifatično jedinjenje">alifatik</a>. <a href="/wiki/N-terminus" title="N-terminus">N-terminalni</a> region varira između različitih tahikinina.<sup id="cite_ref-Ho_2004_6-0" class="reference"><a href="#cite_note-Ho_2004-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Page_2005_7-0" class="reference"><a href="#cite_note-Page_2005-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Datar_2004_8-0" class="reference"><a href="#cite_note-Datar_2004-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Termin tahikinin odražava brzi početak delovanja ovih peptida u glatkim mišićima.<sup id="cite_ref-Datar_2004_8-1" class="reference"><a href="#cite_note-Datar_2004-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Supstanca_P" title="Supstanca P">SP</a> je najistraženiji i najpotentniji član tahikininske familije. On je undekapeptid sa <a href="/wiki/%D0%90%D0%BC%D0%B8%D0%BD%D0%BE%D0%BA%D0%B8%D1%81%D0%B5%D0%BB%D0%B8%D0%BD%D0%B0" title="Аминокиселина">aminokiselinskom</a> sekvencom <a href="/wiki/%D0%90%D1%80%D0%B3%D0%B8%D0%BD%D0%B8%D0%BD" title="Аргинин">Arg</a>-<a href="/wiki/%D0%9F%D1%80%D0%BE%D0%BB%D0%B8%D0%BD" title="Пролин">Pro</a>-<a href="/wiki/Lizin" title="Lizin">Lys</a>-<a href="/wiki/%D0%9F%D1%80%D0%BE%D0%BB%D0%B8%D0%BD" title="Пролин">Pro</a>-<a href="/wiki/%D0%93%D0%BB%D1%83%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Глутамин">Gln</a>-<a href="/wiki/%D0%93%D0%BB%D1%83%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Глутамин">Gln</a>-<a href="/wiki/%D0%A4%D0%B5%D0%BD%D0%B8%D0%BB%D0%B0%D0%BB%D0%B0%D0%BD%D0%B8%D0%BD" title="Фенилаланин">Phe</a>-<a href="/wiki/%D0%A4%D0%B5%D0%BD%D0%B8%D0%BB%D0%B0%D0%BB%D0%B0%D0%BD%D0%B8%D0%BD" title="Фенилаланин">Phe</a>-<a href="/wiki/%D0%93%D0%BB%D0%B8%D1%86%D0%B8%D0%BD" title="Глицин">Gly</a>-<a href="/wiki/Leucin" title="Leucin">Leu</a>-<a href="/wiki/%D0%9C%D0%B5%D1%82%D0%B8%D0%BE%D0%BD%D0%B8%D0%BD" title="Метионин">Met</a>-NH<sub>2</sub>.<sup id="cite_ref-Ho_2004_6-1" class="reference"><a href="#cite_note-Ho_2004-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> SP se vezuje za sva tri tahikininska receptora, ali se najjače vezuje za NK<sub>1</sub> receptor.<sup id="cite_ref-Page_2005_7-1" class="reference"><a href="#cite_note-Page_2005-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Otkrivanje_i_razvoj_lekova">Otkrivanje i razvoj lekova</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonisti_NK1_receptora&veaction=edit&section=2" title="Уредите одељак „Otkrivanje i razvoj lekova”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonisti_NK1_receptora&action=edit&section=2" title="Уреди извор одељка: Otkrivanje i razvoj lekova"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:Development_of_MK-869.sr.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Development_of_MK-869.sr.svg/320px-Development_of_MK-869.sr.svg.png" decoding="async" width="320" height="684" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Development_of_MK-869.sr.svg/480px-Development_of_MK-869.sr.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Development_of_MK-869.sr.svg/640px-Development_of_MK-869.sr.svg.png 2x" data-file-width="459" data-file-height="981" /></a><figcaption>Slika 3. Razvoj MK-869 / <a href="/wiki/Aprepitant" title="Aprepitant">aprepitantа</a></figcaption></figure> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:CP96345.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/CP96345.png/100px-CP96345.png" decoding="async" width="100" height="156" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/CP96345.png/150px-CP96345.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/46/CP96345.png/200px-CP96345.png 2x" data-file-width="1412" data-file-height="2202" /></a><figcaption>Slika 1. CP-96345</figcaption></figure> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:CP-99994.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/CP-99994.svg/100px-CP-99994.svg.png" decoding="async" width="100" height="128" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/CP-99994.svg/150px-CP-99994.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d3/CP-99994.svg/200px-CP-99994.svg.png 2x" data-file-width="265" data-file-height="340" /></a><figcaption>Slika 2. CP-99994</figcaption></figure> <p>Tri grupe istraživača su testirale hemijske kolekcije u potrazi za NK<sub>1</sub> antagonistima <a href="/wiki/1991" title="1991">1991</a>. Eastman Kodak i Sterling Winthrop su otkrili <a href="/wiki/%D0%A1%D1%82%D0%B5%D1%80%D0%BE%D0%B8%D0%B4" title="Стероид">steroidne</a> serije <a href="/wiki/Tahikinin" title="Tahikinin">tahikininskih</a> NK<sub>1</sub> antagonista, međutim ta jedinjenja nisu imala dovoljan <a href="/wiki/Afinitet_(farmakologija)" class="mw-redirect" title="Afinitet (farmakologija)">afinitet</a> za ovaj receptor, uprkos detaljnih <a href="/wiki/Odnos_strukture_i_aktivnosti" title="Odnos strukture i aktivnosti">SAR</a> studija. Te serije su isto tako pokazivale znatnu toksičnost.<sup id="cite_ref-Quartara_2006_9-0" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Quartara_1997_10-0" class="reference"><a href="#cite_note-Quartara_1997-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Rhone-Poulnec otkrila RP-67580, koji ima visok afinitet za NK<sub>1</sub> receptor kod pacova i miševa, ali ne kod ljudi. SAR studije koje su izvršene s ciljom poboljšanja selektivnost za ljudski NK<sub>1</sub> receptor proizvele su jedinjenje RPR-100893. To jedinjenje je pokazivalo dobru aktivnost <i>in vivo</i> i u modelima bola, i dospelo je do faze II za lečenje <a href="/wiki/%D0%9C%D0%B8%D0%B3%D1%80%D0%B5%D0%BD%D0%B0" title="Мигрена">migrene</a>, ali je onda razvoj prekinut, kao što je bio i slučaj sa drugim NK<sub>1</sub> antagonistima testiranim za istu indikaciju.<sup id="cite_ref-Quartara_2006_9-1" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Quartara_1997_10-1" class="reference"><a href="#cite_note-Quartara_1997-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Treća kompanija, <a href="/wiki/Pfizer" title="Pfizer">Pfizer</a>, je otkrila <a href="/wiki/Benzilamin" title="Benzilamin">benzilaminsku</a> <a href="/wiki/Hinuklidin" title="Hinuklidin">hinuklidinsku</a> strukturu, CP-96345 (slika 1). CP-96345 jednostavna struktura, koja sadrži krutu hinuklidinsku osnovu sa baznim azotom, benzhidrilnu <a href="/wiki/Funkcionalna_grupa" title="Funkcionalna grupa">grupu</a> i o-metoksi-benzilaminsku grupu. Ovo jedinjenje je pokazalo visok afinitet za NK<sub>1</sub> receptor, ali je takoše reagovalo sa mestom vezivanja Ca<sup>2+</sup>. Smatralo se da je jako bazni azot hinuklidina odgovoran za to vezivanje, koje uzrokuje brojne sistemske efekte, nevezane za blokiranje NK<sub>1</sub> receptora. Iz tog razloga, i da bi se struktura dodatno pojednostavila, ta pozicija je <a href="/wiki/Alkilacija" title="Alkilacija">alkilovana</a>. </p><p>Jedinjenje CP-99994 je sintetisano zamenom <a href="/wiki/Hinuklidin" title="Hinuklidin">hinuklidinskog</a> prstena <a href="/wiki/Piperidin" title="Piperidin">piperidinom</a> i <a href="/wiki/Benzhidrilna_jedinjenja" title="Benzhidrilna jedinjenja">benzhidrilne</a> <a href="/wiki/Funkcionalna_grupa" title="Funkcionalna grupa">grupe</a> <a href="/wiki/%D0%91%D0%B5%D0%BD%D0%B7%D0%B8%D0%BB" title="Бензил">benzilnom</a> grupom (slika 2).<sup id="cite_ref-Quartara_2006_9-2" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Quartara_1997_10-2" class="reference"><a href="#cite_note-Quartara_1997-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> CP-99994 ima visok afinitet za ljudski NK<sub>1</sub> receptor i znatan broj strukturno–aktivnosnih studija je urađen. One su proizvele strukturne zahteve za interakcije visokog afiniteta sa NK<sub>1</sub> receptorom, dovele do još jednostavnijih molekula sa poboljšanim fizičko-hemijskim i farmakološkim osobinama.<sup id="cite_ref-Quartara_1997_10-3" class="reference"><a href="#cite_note-Quartara_1997-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> CP-99994 umanjuje dentalni bol kod ljudi i bio je u fazi II kliničkih ispitivanja, koja su prekinuta zbog nedovoljne <a href="/wiki/%D0%91%D0%B8%D0%BE%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B8%D0%B2%D0%BE%D1%81%D1%82" title="Биорасположивост">biodostupnosti</a>. Pfizer je istražio nekoliko drugih srodnih serija NK<sub>1</sub> antagonista. CJ-11974, ili ezlopitant, je blizak <a href="/wiki/Strukturni_analog" title="Strukturni analog">analog</a> jedinjenja CP-96345, koji ima izopropilnu grupu na metoksibenzilnom prstenu. On je razvijen do faze II kliničkih ispitivanja za <a href="/wiki/%D0%9D%D0%B5%D0%B6%D0%B5%D1%99%D0%B5%D0%BD%D0%B0_%D0%B4%D0%B5%D1%98%D1%81%D1%82%D0%B2%D0%B0_%D1%85%D0%B5%D0%BC%D0%BE%D1%82%D0%B5%D1%80%D0%B0%D0%BF%D0%B8%D1%98%D0%B5" title="Нежељена дејства хемотерапије">hemoterapijom uzrokovano</a> <a href="/wiki/%D0%9F%D0%BE%D0%B2%D1%80%D0%B0%D1%9B%D0%B0%D1%9A%D0%B5" title="Повраћање">povraćanje</a> pre nego je razvoj prekinut. CP-122721 je CP-99994 analog koji ima trifluorometoksi grupu na o-metoksibenzilnom prstenu. On je bio u fazi II ispitivanja za lečenje depresije, povraćanja i inflamatornih oboljenja, ali je dalji razvoj zaustavljen.<sup id="cite_ref-Quartara_2006_9-3" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Razvoj_prvog_leka">Razvoj prvog leka</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonisti_NK1_receptora&veaction=edit&section=3" title="Уредите одељак „Razvoj prvog leka”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonisti_NK1_receptora&action=edit&section=3" title="Уреди извор одељка: Razvoj prvog leka"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Merck_%26_Co." title="Merck & Co.">Merk</a> je započeo SAR studije NK<sub>1</sub> antagonista <a href="/wiki/1993" title="1993">1993</a>, počevši od CP-96345 i CP-99994. <a href="/wiki/L-733,060" class="mw-redirect" title="L-733,060">L-733,060</a> je jedno od jedinjenja koja su razvijena. Ono ima 3,5-bis trifluorometil <a href="/wiki/%D0%91%D0%B5%D0%BD%D0%B7%D0%B8%D0%BB" title="Бензил">benzil etar</a> <a href="/wiki/Piperidin" title="Piperidin">piperidin</a> umesto 2-metoksi <a href="/w/index.php?title=Benzil_amin&action=edit&redlink=1" class="new" title="Benzil amin (страница не постоји)">benzil aminske</a> <a href="/wiki/Funkcionalna_grupa" title="Funkcionalna grupa">grupe</a> iz CP-99994 jedinjenja. Da bi se poboljšala oralna biodostupnost, supstituenti su dodati na azot piperidina. Grupa koja je proizvela najbolje efekte je 3-okso-1,2,4-triazol-5-il, i tako su nastali L-741671 i L-742694. </p><p>Za <a href="/wiki/Morfolin" title="Morfolin">morfolinsku</a> grupu koje je uvedena u L-742694 je nađeno da povećava NK<sub>1</sub> afinitet vezivanja.<sup id="cite_ref-Humphrey_2003_11-0" class="reference"><a href="#cite_note-Humphrey_2003-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Ta grupa je zadržana u daljim modifikacijama. Da bi se sprečila moguća metabolička deaktivacija, nekoliko poboljšanja kao što su <a href="/wiki/Metilacija" title="Metilacija">metilacija</a> C alfa atoma <a href="/wiki/%D0%91%D0%B5%D0%BD%D0%B7%D0%B8%D0%BB" title="Бензил">benzilovog prstena</a> i <a href="/wiki/%D0%A5%D0%B0%D0%BB%D0%BE%D0%B3%D0%B5%D0%BD%D0%B0%D1%86%D0%B8%D1%98%D0%B0" title="Халогенација">fluorinacija</a> <a href="/w/index.php?title=Fenil_grupa&action=edit&redlink=1" class="new" title="Fenil grupa (страница не постоји)">fenilnog</a> prstena je izvršeno. Te promena su proizvele jedinjenje MK-869, koje ima visok afinitet za NK<sub>1</sub> receptor i visoku oralnu aktivnost (slika 3). MK-869 se još zove <a href="/wiki/Aprepitant" title="Aprepitant">aprepitant</a>. On je izučavan za lečenje bola, <a href="/wiki/%D0%9C%D0%B8%D0%B3%D1%80%D0%B5%D0%BD%D0%B0" title="Мигрена">migrene</a>, <a href="/wiki/%D0%9F%D0%BE%D0%B2%D1%80%D0%B0%D1%9B%D0%B0%D1%9A%D0%B5" title="Повраћање">emesisa</a> i psihijatrijskih poremećaja. Te studije su rezultovale u <a href="/wiki/FDA" class="mw-redirect" title="FDA">FDA</a> odobrenje za upotrebu ovog leka za hemoterapijom izazvanu mučninu i povraćanje. On je dostupan za oralnu upotrebu.<sup id="cite_ref-Quartara_2006_9-4" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> U vodi rastvorni fosforilni prolek za intravenoznu upotrebu, se naziva <a href="/wiki/Fosaprepitant" title="Fosaprepitant">fosaprepitant</a>, ili ivemend.<sup id="cite_ref-Navari_2007_12-0" class="reference"><a href="#cite_note-Navari_2007-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Smatra se da je <a href="/wiki/Aprepitant" title="Aprepitant">aprepitant</a> takođe efektivan u lečenju depresije. On je bio u fazi III kliničkih ispitivanja za tu indikaciju pre nego što je razvoj za tu indikaciju prekinut.<sup id="cite_ref-Quartara_2006_9-5" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Druga_jedinjenja">Druga jedinjenja</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonisti_NK1_receptora&veaction=edit&section=4" title="Уредите одељак „Druga jedinjenja”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonisti_NK1_receptora&action=edit&section=4" title="Уреди извор одељка: Druga jedinjenja"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:GR-205171.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/GR-205171.svg/120px-GR-205171.svg.png" decoding="async" width="120" height="100" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/GR-205171.svg/180px-GR-205171.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a3/GR-205171.svg/240px-GR-205171.svg.png 2x" data-file-width="408" data-file-height="340" /></a><figcaption>Slika 4. GR-205171</figcaption></figure> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:LY-303870.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/LY-303870.svg/120px-LY-303870.svg.png" decoding="async" width="120" height="150" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/LY-303870.svg/180px-LY-303870.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e5/LY-303870.svg/240px-LY-303870.svg.png 2x" data-file-width="454" data-file-height="568" /></a><figcaption>Slika 5. LY-303870 / lanepitant</figcaption></figure> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:TAK-637.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/TAK-637.svg/120px-TAK-637.svg.png" decoding="async" width="120" height="94" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/TAK-637.svg/180px-TAK-637.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/47/TAK-637.svg/240px-TAK-637.svg.png 2x" data-file-width="484" data-file-height="381" /></a><figcaption>Slika 6. TAK-637</figcaption></figure> <p>Razne druge farmaceutske kompanije su opisale mnoga druga jedinjenja pored jedinjenja koja su dovela do otkrića aprepitanta. <a href="/wiki/GlaksoSmitKlajn" class="mw-redirect" title="GlaksoSmitKlajn">Glakso</a> je razvio GR-205171 (slika 4) na osnovu CP-99994. GR-205171 sadrži <a href="/wiki/Tetrazol" title="Tetrazol">tetrazolni</a> prsten u poziciji 4 <a href="/wiki/%D0%91%D0%B5%D0%BD%D0%B7%D0%B8%D0%BB" title="Бензил">benzilnog</a> prstena. Ta grupa povišava oralnu <a href="/wiki/%D0%91%D0%B8%D0%BE%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B8%D0%B2%D0%BE%D1%81%D1%82" title="Биорасположивост">bioraspoloživost</a> i poboljšava farmakokinetičke osobine. On je razvijen do faze II kliničkih ispitivanja za lečenje postoperativne mučnine i povraćanja, <a href="/wiki/%D0%9C%D0%B8%D0%B3%D1%80%D0%B5%D0%BD%D0%B0" title="Мигрена">migrene</a> i <a href="/wiki/%D0%91%D0%BE%D0%BB%D0%B5%D1%81%D1%82_%D0%BA%D1%80%D0%B5%D1%82%D0%B0%D1%9A%D0%B0" title="Болест кретања">bolesti kretanja</a>. On je imao povoljne rezultate u <a href="/wiki/%D0%9F%D0%BE%D0%B2%D1%80%D0%B0%D1%9B%D0%B0%D1%9A%D0%B5" title="Повраћање">emesis</a> tretmanima, ali je razvoj prekinut.<sup id="cite_ref-Quartara_2006_9-6" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>LY-303870, ili <a href="/w/index.php?title=Lanepitant&action=edit&redlink=1" class="new" title="Lanepitant (страница не постоји)">lanepitant</a> (slika 5), je N-acetilisani redukovani <a href="/wiki/Amid" title="Amid">amid</a> <a href="/wiki/Triptofan" title="Triptofan">L-triptofana</a>, koji je otkrila kompanija <a href="/wiki/Eli_Lili_i_kompanija" class="mw-redirect" title="Eli Lili i kompanija">Eli Lili</a>. Ovaj lek je bio u fazi IIa kliničkih ispitivanja za tretman osteoartritisnog bola, ali nije pokazao značajne efekte. Eli Lili je izvršila dalja <a href="/wiki/Odnos_strukture_i_aktivnosti" title="Odnos strukture i aktivnosti">SAR</a> ispitivanja i razvila niz drugih jedinjenja, ali ona nisu dospela do kliničkih ispitivanja.<sup id="cite_ref-Quartara_2006_9-7" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Kompanija <a href="/w/index.php?title=Takeda&action=edit&redlink=1" class="new" title="Takeda (страница не постоји)">Takeda</a> je otkrila seriju N-benzilkarboksiamida koristeći opštu hipotezu o <a href="/wiki/Peptid" title="Peptid">peptidnom</a> vezivnom mestu na <a href="/wiki/G_protein_spregnuti_receptori" class="mw-redirect" title="G protein spregnuti receptori">G protein-spregnutim receptorima</a>. Jedno od tih jedinjenja, TAK-637 (slika 6), je bilo u fazi II kliničkih ispitivanja za urinarnu inkontinenciju, depresiju i upalnu bolest creva, ali je razvoj prekinut. Postoji niz drugih jedinjenja koja su istraživana ali koja nisu dospela do kliničkih ispitivanja. Dalja istraživanja su u toku.<sup id="cite_ref-Quartara_2006_9-8" class="reference"><a href="#cite_note-Quartara_2006-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Humphrey_2003_11-1" class="reference"><a href="#cite_note-Humphrey_2003-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Vezivanje">Vezivanje</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonisti_NK1_receptora&veaction=edit&section=5" title="Уредите одељак „Vezivanje”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonisti_NK1_receptora&action=edit&section=5" title="Уреди извор одељка: Vezivanje"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>NK<sub>1</sub> receptor sadrži više domena za vezivanje ne-peptidnih <a href="/wiki/Antagonist_(farmakologija)" title="Antagonist (farmakologija)">antagonista</a>. Glavno mesto vezivanja liganda je u <a href="/wiki/Hidrofobnost" class="mw-redirect" title="Hidrofobnost">hidrofobnom</a> jezgru između petlji i spoljašnjih segmenata <a href="/wiki/Transmembranski_domen" title="Transmembranski domen">transmembranskih domena</a> 3–7 (TM3–TM7).<sup id="cite_ref-Almeida_2004_13-0" class="reference"><a href="#cite_note-Almeida_2004-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Nekoliko ostataka, kao što su <a href="/wiki/%D0%93%D0%BB%D1%83%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Глутамин">Gln</a>165 (TM4), <a href="/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Хистидин">His</a>197 (TM5), His265 (TM6) i <a href="/wiki/%D0%A2%D0%B8%D1%80%D0%BE%D0%B7%D0%B8%D0%BD" title="Тирозин">Tyr</a>287 (TM7) učestvuju u vezivanju mnogih ne-peptidnih <a href="/wiki/Receptor_(biohemija)" title="Receptor (biohemija)">antagonista</a> NK<sub>1</sub> receptora.<sup id="cite_ref-Almeida_2004_13-1" class="reference"><a href="#cite_note-Almeida_2004-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Maggi_1994_14-0" class="reference"><a href="#cite_note-Maggi_1994-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p>Zamena His197 <a href="/wiki/%D0%90%D0%BB%D0%B0%D0%BD%D0%B8%D0%BD" title="Аланин">alaninom</a> umanjuje afinitet vezivanja CP-96345 za NK<sub>1</sub> receptor. His197 formira vezu sa njegovom <a href="/wiki/Benzhidrilna_jedinjenja" title="Benzhidrilna jedinjenja">benzhidrilnom</a> grupom. Eksperimentalno je pokazano da zamena <a href="/wiki/Valin" title="Valin">Val</a>116 (TM3) i <a href="/wiki/Izoleucin" title="Izoleucin">Ile</a>290 (TM7) umanjuje afinitet vezivanja CP-96345. Smatra se da ti ostaci nemaju direktne interakcije sa antagonistima, nego da indirektno utiču na konformaciju mesta vezivanja antagonista. </p><p>Za <a href="/wiki/%D0%93%D0%BB%D1%83%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Глутамин">Gln</a>165 (TM4) je takođe bilo pokazano da učestvuje u vezivanju nekoliko ne-peptidnih antagonista, verovatno putem formiranja <a href="/wiki/%D0%92%D0%BE%D0%B4%D0%BE%D0%BD%D0%B8%D1%87%D0%BD%D0%B0_%D0%B2%D0%B5%D0%B7%D0%B0" title="Водонична веза">vodonične veze</a>.<sup id="cite_ref-Quartara_1997_10-4" class="reference"><a href="#cite_note-Quartara_1997-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Pennefather_2004_15-0" class="reference"><a href="#cite_note-Pennefather_2004-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Za <a href="/wiki/%D0%A4%D0%B5%D0%BD%D0%B8%D0%BB%D0%B0%D0%BB%D0%B0%D0%BD%D0%B8%D0%BD" title="Фенилаланин">Phe</a>268 i <a href="/wiki/%D0%A2%D0%B8%D1%80%D0%BE%D0%B7%D0%B8%D0%BD" title="Тирозин">Tyr</a>287 se pretpostavlja da su moguće tačke kontakta za domena vezivanja agonist i antagonista.<sup id="cite_ref-Almeida_2004_13-2" class="reference"><a href="#cite_note-Almeida_2004-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Učešće His265 u vezivanju antagonista NK<sub>1</sub> receptora je bilo potvrđeno. His265 ima povoljnu interakciju sa 3,5-bis-trifluorometil fenilnom grupom (TFMP grupa) CP-96345 analoga. Međutim, isto tako je pokazano da Ala-zamena His265 nema efekta na afinitet vezivanja CP-96345.<sup id="cite_ref-Humphrey_2003_11-2" class="reference"><a href="#cite_note-Humphrey_2003-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Za još neke druge ostatke se smatra da učestvuju u vezivanju ne-peptidnih antagonista za NK<sub>1</sub> receptor: <a href="/wiki/Serin" title="Serin">Ser</a>169, <a href="/wiki/Glutaminska_kiselina" title="Glutaminska kiselina">Glu</a>193, <a href="/wiki/Lizin" title="Lizin">Lys</a>194, <a href="/wiki/%D0%A4%D0%B5%D0%BD%D0%B8%D0%BB%D0%B0%D0%BB%D0%B0%D0%BD%D0%B8%D0%BD" title="Фенилаланин">Phe</a>264, <a href="/wiki/%D0%A4%D0%B5%D0%BD%D0%B8%D0%BB%D0%B0%D0%BB%D0%B0%D0%BD%D0%B8%D0%BD" title="Фенилаланин">Phe</a>267, <a href="/wiki/%D0%9F%D1%80%D0%BE%D0%BB%D0%B8%D0%BD" title="Пролин">Pro</a>271 i <a href="/wiki/%D0%A2%D0%B8%D1%80%D0%BE%D0%B7%D0%B8%D0%BD" title="Тирозин">Tyr</a>272. </p><p>Izgleda da svaka strukturna klasa ne-peptidnih NK<sub>1</sub> antagonista formira interakcija sa specifičnom grupom ostataka unutar zajedničkog aktivnog mesta.<sup id="cite_ref-Almeida_2004_13-3" class="reference"><a href="#cite_note-Almeida_2004-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Maggi_1994_14-1" class="reference"><a href="#cite_note-Maggi_1994-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonisti_NK1_receptora&veaction=edit&section=6" title="Уредите одељак „Literatura”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonisti_NK1_receptora&action=edit&section=6" title="Уреди извор одељка: Literatura"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440201">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><cite class="citation journal">Varty GB, Cohen-Williams ME, Hunter JC (2003). „The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test”. <i>Behavioural pharmacology</i>. <b>14</b> (1): 87—95. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12576885">12576885</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F01.fbp.0000055962.09493.e9">10.1097/01.fbp.0000055962.09493.e9</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=The+antidepressant-like+effects+of+neurokinin+NK1+receptor+antagonists+in+a+gerbil+tail+suspension+test&rft.au=Cohen-Williams%2C+ME&rft.au=Hunter%2C+JC&rft.aufirst=GB&rft.aulast=Varty&rft.date=2003&rft.genre=article&rft.issue=1&rft.jtitle=Behavioural+pharmacology&rft.pages=87-95&rft.volume=14&rft_id=info%3Adoi%2F10.1097%2F01.fbp.0000055962.09493.e9&rft_id=info%3Apmid%2F12576885&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><cite class="citation journal">Varty GB; 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Приступљено <span class="nowrap">16. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=Substance+P%3A+Structure%2C+Function%2C+and+Therapeutics&rft.au=Coutinho+E.&rft.au=Datar+P.&rft.au=Govil+G.&rft.au=Srivastava+S.&rft.date=2004&rft.genre=article&rft.issue=1&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.pages=75-103&rft.volume=4&rft_id=http%3A%2F%2Fweb.ebscohost.com%2Fehost%2Fdetail%3Fvid%3D3%26hid%3D14%26sid%3Dcbd0171a-72ef-47c3-bae2-063f39b1af3a%2540sessionmgr2%26bdata%3DJnNpdGU9ZWhvc3QtbGl2ZQ%253d%253d%23db%3Daph%26AN%3D12076762%3DCitation&rft_id=info%3Adoi%2F10.2174%2F1568026043451636&rft_id=info%3Apmid%2F14754378&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Quartara_2006-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-Quartara_2006_9-0"><sup><i><b>а</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-1"><sup><i><b>б</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-2"><sup><i><b>в</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-3"><sup><i><b>г</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-4"><sup><i><b>д</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-5"><sup><i><b>ђ</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-6"><sup><i><b>е</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-7"><sup><i><b>ж</b></i></sup></a> <a href="#cite_ref-Quartara_2006_9-8"><sup><i><b>з</b></i></sup></a></span> <span class="reference-text"><cite class="citation journal">Quartara L, Altamura M (2006). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110725065700/http://www.benthamdirect.org/pages/content.php?CDT%2F2006%2F00000007%2F00000008%2F0007J.SGM">„Tachykinin receptors antagonists: from research to clinic”</a>. <i>Current Drug Targets</i>. <b>7</b> (8): 975—92. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16918326">16918326</a>. Архивирано из <a rel="nofollow" class="external text" href="http://www.benthamdirect.org/pages/content.php?CDT/2006/00000007/00000008/0007J.SGM">оригинала</a> 25. 07. 2011. г<span class="reference-accessdate">. Приступљено <span class="nowrap">17. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=Tachykinin+receptors+antagonists%3A+from+research+to+clinic&rft.au=Altamura%2C+M&rft.aufirst=L&rft.aulast=Quartara&rft.date=2006&rft.genre=article&rft.issue=8&rft.jtitle=Current+Drug+Targets&rft.pages=975-92&rft.volume=7&rft_id=http%3A%2F%2Fwww.benthamdirect.org%2Fpages%2Fcontent.php%3FCDT%2F2006%2F00000007%2F00000008%2F0007J.SGM&rft_id=info%3Apmid%2F16918326&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Quartara_1997-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-Quartara_1997_10-0"><sup><i><b>а</b></i></sup></a> <a href="#cite_ref-Quartara_1997_10-1"><sup><i><b>б</b></i></sup></a> <a href="#cite_ref-Quartara_1997_10-2"><sup><i><b>в</b></i></sup></a> <a href="#cite_ref-Quartara_1997_10-3"><sup><i><b>г</b></i></sup></a> <a href="#cite_ref-Quartara_1997_10-4"><sup><i><b>д</b></i></sup></a></span> <span class="reference-text"><cite class="citation journal">Quartara L, Maggi CA (1997). <a rel="nofollow" class="external text" href="http://www.neuropeptidesjournal.com/article/S0143-4179%2897%2990001-9/abstract">„The tachykinin NK1 receptor. 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Приступљено <span class="nowrap">17. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=The+tachykinin+NK1+receptor.+Part+I%3A+ligands+and+mechanisms+of+cellular+activation&rft.au=Maggi%2C+CA&rft.aufirst=L&rft.aulast=Quartara&rft.date=1997&rft.genre=article&rft.issue=6&rft.jtitle=Neuropeptides&rft.pages=537-63&rft.volume=31&rft_id=http%3A%2F%2Fwww.neuropeptidesjournal.com%2Farticle%2FS0143-4179%252897%252990001-9%2Fabstract&rft_id=info%3Adoi%2F10.1016%2FS0143-4179%2897%2990001-9&rft_id=info%3Apmid%2F9574822&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Humphrey_2003-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-Humphrey_2003_11-0"><sup><i><b>а</b></i></sup></a> <a href="#cite_ref-Humphrey_2003_11-1"><sup><i><b>б</b></i></sup></a> <a href="#cite_ref-Humphrey_2003_11-2"><sup><i><b>в</b></i></sup></a></span> <span class="reference-text"><cite class="citation journal">Humphrey JM (2003). <a rel="nofollow" class="external text" href="http://www.benthamdirect.org/pages/content.php?CTMC/2003/00000003/00000012/0011R.SGM">„Medicinal chemistry of selective neurokinin-1 antagonists”</a>. <i>Current Topics in Medicinal Chemistry</i>. <b>3</b> (12): 1423—35. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12871173">12871173</a><span class="reference-accessdate">. Приступљено <span class="nowrap">17. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=Medicinal+chemistry+of+selective+neurokinin-1+antagonists&rft.au=Humphrey+JM&rft.date=2003&rft.genre=article&rft.issue=12&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.pages=1423-35&rft.volume=3&rft_id=http%3A%2F%2Fwww.benthamdirect.org%2Fpages%2Fcontent.php%3FCTMC%2F2003%2F00000003%2F00000012%2F0011R.SGM&rft_id=info%3Apmid%2F12871173&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%9C%D1%80%D1%82%D0%B2%D0%B0_%D0%B2%D0%B5%D0%B7%D0%B0" title="Википедија:Мртва веза"><span title=" Ова веза је мртва и треба је или поправити или уклонити (септембар 2018)">мртва веза</span></a></i>]</span></sup></span> </li> <li id="cite_note-Navari_2007-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-Navari_2007_12-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Navari RM (2007). <a rel="nofollow" class="external text" href="http://informahealthcare.com/doi/abs/10.1517/13543784.16.12.1977%20">„Fosaprepitant (MK-0517): a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting”</a>. <i>Expert Opinion on Investigational Drugs</i>. <b>16</b> (12): 1977—85. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/18042005">18042005</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1517%2F13543784.16.12.1977">10.1517/13543784.16.12.1977</a><span class="reference-accessdate">. Приступљено <span class="nowrap">17. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=Fosaprepitant+%28MK-0517%29%3A+a+neurokinin-1+receptor+antagonist+for+the+prevention+of+chemotherapy-induced+nausea+and+vomiting&rft.au=Navari+RM&rft.date=2007&rft.genre=article&rft.issue=12&rft.jtitle=Expert+Opinion+on+Investigational+Drugs&rft.pages=1977-85&rft.volume=16&rft_id=http%3A%2F%2Finformahealthcare.com%2Fdoi%2Fabs%2F10.1517%2F13543784.16.12.1977%2520&rft_id=info%3Adoi%2F10.1517%2F13543784.16.12.1977&rft_id=info%3Apmid%2F18042005&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%9C%D1%80%D1%82%D0%B2%D0%B0_%D0%B2%D0%B5%D0%B7%D0%B0" title="Википедија:Мртва веза"><span title=" Ова веза је мртва и треба је или поправити или уклонити (јул 2019)">мртва веза</span></a></i>]</span></sup></span> </li> <li id="cite_note-Almeida_2004-13"><span class="mw-cite-backlink">^ <a href="#cite_ref-Almeida_2004_13-0"><sup><i><b>а</b></i></sup></a> <a href="#cite_ref-Almeida_2004_13-1"><sup><i><b>б</b></i></sup></a> <a href="#cite_ref-Almeida_2004_13-2"><sup><i><b>в</b></i></sup></a> <a href="#cite_ref-Almeida_2004_13-3"><sup><i><b>г</b></i></sup></a></span> <span class="reference-text"><cite class="citation journal">Almeida TA, Rojo J, Nieto PM, Pinto FM, Hernandez M, Martín JD, Candenas ML (2004). <a rel="nofollow" class="external text" href="http://www.benthamdirect.org/pages/content.php?CMC/2004/00000011/00000015/0008C.SGM">„Tachykinins and tachykinin receptors: structure and activity relationships”</a>. <i>Current Medicinal Chemistry</i>. <b>11</b> (15): 2045—81. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15279567">15279567</a><span class="reference-accessdate">. Приступљено <span class="nowrap">18. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=Tachykinins+and+tachykinin+receptors%3A+structure+and+activity+relationships&rft.au=Candenas%2C+ML&rft.au=Hernandez%2C+M&rft.au=Mart%C3%ADn%2C+JD&rft.au=Nieto%2C+PM&rft.au=Pinto%2C+FM&rft.au=Rojo%2C+J&rft.aufirst=TA&rft.aulast=Almeida&rft.date=2004&rft.genre=article&rft.issue=15&rft.jtitle=Current+Medicinal+Chemistry&rft.pages=2045-81&rft.volume=11&rft_id=http%3A%2F%2Fwww.benthamdirect.org%2Fpages%2Fcontent.php%3FCMC%2F2004%2F00000011%2F00000015%2F0008C.SGM&rft_id=info%3Apmid%2F15279567&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%9C%D1%80%D1%82%D0%B2%D0%B0_%D0%B2%D0%B5%D0%B7%D0%B0" title="Википедија:Мртва веза"><span title=" Ова веза је мртва и треба је или поправити или уклонити (септембар 2018)">мртва веза</span></a></i>]</span></sup></span> </li> <li id="cite_note-Maggi_1994-14"><span class="mw-cite-backlink">^ <a href="#cite_ref-Maggi_1994_14-0"><sup><i><b>а</b></i></sup></a> <a href="#cite_ref-Maggi_1994_14-1"><sup><i><b>б</b></i></sup></a></span> <span class="reference-text"><cite class="citation journal">Maggi CA (1995). <a rel="nofollow" class="external text" href="http://linkinghub.elsevier.com/retrieve/pii/030636239400292U">„The mammalian tachykinin receptors”</a>. <i>General Pharmacology</i>. <b>26</b> (5): 911—44. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/7557266">7557266</a><span class="reference-accessdate">. Приступљено <span class="nowrap">18. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=The+mammalian+tachykinin+receptors&rft.au=Maggi+CA&rft.date=1995&rft.genre=article&rft.issue=5&rft.jtitle=General+Pharmacology&rft.pages=911-44&rft.volume=26&rft_id=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2F030636239400292U&rft_id=info%3Apmid%2F7557266&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Pennefather_2004-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-Pennefather_2004_15-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Pennefather JN, Lecci A, Candenas ML, Patak E, Pinto FM, Maggi CA (2004). <a rel="nofollow" class="external text" href="http://linkinghub.elsevier.com/retrieve/pii/S0024320503010385">„Tachykinins and tachykinin receptors: a growing family”</a>. <i>Life Sciences</i>. <b>74</b> (12): 1445—63. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/14729395">14729395</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.lfs.2003.09.039">10.1016/j.lfs.2003.09.039</a><span class="reference-accessdate">. Приступљено <span class="nowrap">18. 04. 2011</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AAntagonisti+NK1+receptora&rft.atitle=Tachykinins+and+tachykinin+receptors%3A+a+growing+family&rft.au=Candenas%2C+ML&rft.au=Lecci%2C+A&rft.au=Maggi%2C+CA&rft.au=Patak%2C+E&rft.au=Pinto%2C+FM&rft.aufirst=JN&rft.aulast=Pennefather&rft.date=2004&rft.genre=article&rft.issue=12&rft.jtitle=Life+Sciences&rft.pages=1445-63&rft.volume=74&rft_id=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0024320503010385&rft_id=info%3Adoi%2F10.1016%2Fj.lfs.2003.09.039&rft_id=info%3Apmid%2F14729395&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Antagonisti_NK1_receptora&veaction=edit&section=7" title="Уредите одељак „Spoljašnje veze”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Antagonisti_NK1_receptora&action=edit&section=7" title="Уреди извор одељка: Spoljašnje veze"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://leaddiscovery.blogspot.com/2006/02/nk1-receptor-antagonist-by-roche.html">Antagonisti NK1 receptora</a></li></ul> <div style="clear:both;"></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r25469611">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline 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transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A3%D1%80%D0%B5%D0%B4%D0%B8_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83/%C5%A0ablon:Antiemetici" title="Посебно:Уреди страницу/Šablon:Antiemetici"><abbr title="Uredite šablon" style=";;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Antiemetici_(A04)" style="font-size:114%;margin:0 4em"><a href="/wiki/Antiemetik" title="Antiemetik">Antiemetici</a> (<a href="/wiki/ATC_kod_A04" title="ATC kod A04">A04</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#fd6;"><a href="/wiki/5-HT3_antagonist" title="5-HT3 antagonist">5-HT<sub>3</sub> Antagonisti</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alosetron" title="Alosetron">Alosetron</a></li> <li><a href="/wiki/Azasetron" title="Azasetron">Azasetron</a></li> <li><a href="/wiki/Bemesetron" title="Bemesetron">Bemesetron</a></li> <li><a href="/wiki/Cilansetron" title="Cilansetron">Cilansetron</a></li> <li><a href="/wiki/Klozapin" title="Klozapin">Klozapin</a></li> <li><a href="/wiki/Dazopride" class="mw-redirect" title="Dazopride">Dazopride</a></li> <li><a href="/wiki/Dolasetron" title="Dolasetron">Dolasetron</a></li> <li><a href="/wiki/Granisetron" title="Granisetron">Granisetron</a></li> <li><a href="/wiki/Lerisetron" title="Lerisetron">Lerisetron</a></li> <li><a href="/wiki/Metoclopramide" class="mw-redirect" title="Metoclopramide">Metoclopramide</a></li> <li><a href="/wiki/Mianserin" class="mw-redirect" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapin" title="Mirtazapin">Mirtazapin</a></li> <li><a href="/wiki/Olanzapin" title="Olanzapin">Olanzapin</a></li> <li><a href="/wiki/Ondansetron" title="Ondansetron">Ondansetron</a></li> <li><a href="/wiki/Palonosetron" title="Palonosetron">Palonosetron</a></li> <li><a href="/wiki/Ramosetron" title="Ramosetron">Ramosetron</a></li> <li><a href="/wiki/Ricasetron" class="mw-redirect" title="Ricasetron">Ricasetron</a></li> <li><a href="/wiki/Tropisetron" title="Tropisetron">Tropisetron</a></li> <li><a href="/wiki/Zatosetron" title="Zatosetron">Zatosetron</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#fd6;"><a href="/wiki/Kanabinoidni_receptor_tip_1" title="Kanabinoidni receptor tip 1">CB<sub>1</sub></a> <a href="/wiki/Agonist_(farmakologija)" title="Agonist (farmakologija)">Agonisti</a> (<a href="/wiki/Kanabinoid" title="Kanabinoid">Kanabinoidi</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dronabinol" class="mw-redirect" title="Dronabinol">Dronabinol</a></li> <li><a href="/wiki/Nabilon" title="Nabilon">Nabilon</a></li> <li><a href="/wiki/Nonabin" title="Nonabin">Nonabin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#fd6;"><a href="/wiki/Antagonist_dopaminskog_receptora" title="Antagonist dopaminskog receptora">D<sub>2</sub>/D<sub>3</sub> Antagonisti</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alizaprid" title="Alizaprid">Alizaprid</a></li> <li><a href="/wiki/Bromoprid" title="Bromoprid">Bromoprid</a></li> <li><a href="/wiki/%D0%A5%D0%BB%D0%BE%D1%80%D0%BF%D1%80%D0%BE%D0%BC%D0%B0%D0%B7%D0%B8%D0%BD" title="Хлорпромазин">Hlorpromazin</a></li> <li><a href="/wiki/Kleboprid" title="Kleboprid">Kleboprid</a></li> <li><a href="/wiki/Domperidon" title="Domperidon">Domperidon</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/wiki/Itoprid" title="Itoprid">Itoprid</a></li> <li><a href="/wiki/Metoklopramid" title="Metoklopramid">Metoklopramid</a></li> <li><a href="/wiki/Metopimazin" title="Metopimazin">Metopimazin</a></li> <li><a href="/wiki/Prohlorperazin" title="Prohlorperazin">Prohlorperazin</a></li> <li><a href="/wiki/Tietilperazin" title="Tietilperazin">Tietilperazin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#fd6;"><a href="/wiki/H1_antagonist" title="H1 antagonist">H<sub>1</sub> Antagonisti</a> (<a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%85%D0%B8%D1%81%D1%82%D0%B0%D0%BC%D0%B8%D0%BD%D0%B8%D0%BA" title="Антихистаминик">Antihistamini</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ciklizin" title="Ciklizin">Ciklizin</a></li> <li><a href="/wiki/Dimenhidrinat" title="Dimenhidrinat">Dimenhidrinat</a></li> <li><a href="/wiki/Difenhidramin" title="Difenhidramin">Difenhidramin</a></li> <li><a href="/wiki/Meklizin" title="Meklizin">Meklizin</a></li> <li><a href="/wiki/Prometazin" title="Prometazin">Prometazin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#fd6;"><a href="/wiki/Muskarinski_acetilholinski_receptor" title="Muskarinski acetilholinski receptor">mACh</a> <a href="/wiki/Antagonist_(farmakologija)" title="Antagonist (farmakologija)">Antagonisti</a> (<a href="/wiki/Antiholini" class="mw-redirect" title="Antiholini">Antiholini</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/%D0%90%D1%82%D1%80%D0%BE%D0%BF%D0%B8%D0%BD" title="Атропин">Atropin</a></li> <li><a href="/wiki/Hiosciamin" title="Hiosciamin">Hiosciamin</a></li> <li><a href="/wiki/Skopolamin" title="Skopolamin">Skopolamin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#fd6;"><a class="mw-selflink selflink">q<sub>1</sub> Antagonisti</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aprepitant" title="Aprepitant">Aprepitant</a></li> <li><a href="/wiki/Kasopitant" title="Kasopitant">Kasopitant</a></li> <li><a href="/wiki/Ezlopitant" title="Ezlopitant">Ezlopitant</a></li> <li><a href="/wiki/Fosaprepitant" title="Fosaprepitant">Fosaprepitant</a></li> <li><a href="/wiki/Maropitant" title="Maropitant">Maropitant</a></li> <li><a href="/wiki/Vestipitant" title="Vestipitant">Vestipitant</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#fd6;">Drugi</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cerijum_oksalat" title="Cerijum oksalat">Cerijum oksalat</a></li> <li><a href="/wiki/Deksametazon" title="Deksametazon">Deksametazon</a></li> <li><a href="/wiki/Lorazepam" title="Lorazepam">Lorazepam</a></li> <li><a href="/wiki/Midazolam" title="Midazolam">Midazolam</a></li> <li><a href="/wiki/%D0%9F%D1%80%D0%BE%D0%BF%D0%BE%D1%84%D0%BE%D0%BB" title="Пропофол">Propofol</a></li> <li><a href="/wiki/Trimetobenzamid" title="Trimetobenzamid">Trimetobenzamid</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background: transparent; padding: 0px;"><div> <ul><li class="mw-empty-elt"></li></ul></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0;background:transparent;color:inherit;"><div style="padding:0px;"><table class="navbox-columns-table" style="border-spacing: 0px; text-align:left;width:100%;"><tbody><tr style="vertical-align:top;"><td class="navbox-list" style="padding:0px;text-align:center;background:#efefef;;;text-align:center;background:#fd6;;width:10em;"><div> <p><a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:%D0%9C%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%D0%BD%D0%B0_%D0%BD%D0%B0%D0%B2%D1%81" class="mw-redirect" title="Шаблон:Медицина навс">M</a>: <a href="/wiki/%D0%A1%D0%B8%D1%81%D1%82%D0%B5%D0%BC_%D0%BE%D1%80%D0%B3%D0%B0%D0%BD%D0%B0_%D0%B7%D0%B0_%D0%B2%D0%B0%D1%80%D0%B5%D1%9A%D0%B5" title="Систем органа за варење">DIG</a> </p> </div></td><td class="navbox-list" style="border-left:2px solid #fdfdfd;padding:0px;text-align:center;background:#efefef;;;text-align:center;background:white;;width:10em;"><div> <p>anat(<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Digestivni_trakt&action=edit&redlink=1" class="new" title="Шаблон:Digestivni trakt (страница не постоји)">t</a>, <a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Pomo%C4%87ne_digestivne_%C5%BElezde&action=edit&redlink=1" class="new" title="Шаблон:Pomoćne digestivne žlezde (страница не постоји)">g</a>, <a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Abdomenopelvi%C4%8Dna_%C5%A1upljina&action=edit&redlink=1" class="new" title="Шаблон:Abdomenopelvična šupljina (страница не постоји)">p</a>)/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Gastrointestinalna_fiziologija&action=edit&redlink=1" class="new" title="Шаблон:Gastrointestinalna fiziologija (страница не постоји)">phys</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Razvoj_digestivnog_sistema&action=edit&redlink=1" class="new" title="Шаблон:Razvoj digestivnog sistema (страница не постоји)">devp</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Digestivni_enzimi&action=edit&redlink=1" class="new" title="Шаблон:Digestivni enzimi (страница не постоји)">enzy</a> </p> </div></td><td class="navbox-list" style="border-left:2px solid #fdfdfd;padding:0px;text-align:center;background:#efefef;;;text-align:center;background:silver;;width:10em;"><div> <p><a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Bolesti_digestivnog_sistema&action=edit&redlink=1" class="new" title="Шаблон:Bolesti digestivnog sistema (страница не постоји)">noco</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Kongenitalne_malformacije_i_deformacije_digestivnog_sistema&action=edit&redlink=1" class="new" title="Шаблон:Kongenitalne malformacije i deformacije digestivnog sistema (страница не постоји)">cong</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Neoplazija_digestivnog_sistema&action=edit&redlink=1" class="new" title="Шаблон:Neoplazija digestivnog sistema (страница не постоји)">tumr</a>, <a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Simptomi_i_znaci_digestivnog_sistema_i_abdomena&action=edit&redlink=1" class="new" title="Шаблон:Simptomi i znaci digestivnog sistema i abdomena (страница не постоји)">sysi</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Eponimni_medicinski_znaci_za_digestivni_sistem_i_generalni_abdominalni_znaci&action=edit&redlink=1" class="new" title="Шаблон:Eponimni medicinski znaci za digestivni sistem i generalni abdominalni znaci (страница не постоји)">epon</a> </p> </div></td><td class="navbox-list" style="border-left:2px solid #fdfdfd;padding:0px;text-align:center;background:#efefef;;;text-align:center;background:#ccf;;width:10em;"><div> <p><a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Procecure_digestivnog_sistema&action=edit&redlink=1" class="new" title="Шаблон:Procecure digestivnog sistema (страница не постоји)">proc</a>, <a href="/wiki/ATC_kod_A" title="ATC kod A">drug</a>(<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Antacidi&action=edit&redlink=1" class="new" title="Шаблон:Antacidi (страница не постоји)">A2A</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Lekovi_za_%C4%8Dir_na_dvanaestopala%C4%8Dnom_crevu_i_GORD&action=edit&redlink=1" class="new" title="Шаблон:Lekovi za čir na dvanaestopalačnom crevu i GORD (страница не постоји)">2B</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Lekovi_za_funkcionalne_gastrointestinalne_bolesti&action=edit&redlink=1" class="new" title="Шаблон:Lekovi za funkcionalne gastrointestinalne bolesti (страница не постоји)">3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:%D0%90%D0%BD%D1%82%D0%B8%D0%B5%D0%BC%D0%B5%D1%82%D0%B8%D1%86%D0%B8" title="Шаблон:Антиеметици">4</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Terapija_%C5%BEu%C4%8Di_i_jetre&action=edit&redlink=1" class="new" title="Шаблон:Terapija žuči i jetre (страница не постоји)">5</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:%D0%9B%D0%B0%D0%BA%D1%81%D0%B0%D1%82%D0%B8%D0%B2%D0%B8" title="Шаблон:Лаксативи">6</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Antidijarejski,_intestinalni_antiinflamatorin/antiinfektivni_agensi&action=edit&redlink=1" class="new" title="Шаблон:Antidijarejski, intestinalni antiinflamatorin/antiinfektivni agensi (страница не постоји)">7</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Anaboli%C4%8Dki_steroidi&action=edit&redlink=1" class="new" title="Шаблон:Anabolički steroidi (страница не постоји)">14</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Drugi_produkti_alimentarnog_trakta_i_metabolizma&action=edit&redlink=1" class="new" title="Шаблон:Drugi produkti alimentarnog trakta i metabolizma (страница не постоји)">16</a>), <a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Klini%C4%8Dki_biohemijski_krvni_testovi&action=edit&redlink=1" class="new" title="Шаблон:Klinički biohemijski krvni testovi (страница не постоји)">blte</a> </p> 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title="Шаблон:Антидепресиви"><abbr title="Pogledajte šablon" style=";;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">p</abbr></a></li><li class="nv-razgovor"><a href="/w/index.php?title=Razgovor_o_%C5%A1ablonu:Antidepresivi&action=edit&redlink=1" class="new" title="Razgovor o šablonu:Antidepresivi (страница не постоји)"><abbr title="Razgovarajte o šablonu" style=";;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A3%D1%80%D0%B5%D0%B4%D0%B8_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83/%C5%A0ablon:Antidepresivi" title="Посебно:Уреди страницу/Šablon:Antidepresivi"><abbr title="Uredite šablon" style=";;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Antidepresivi_(-&#123;N06A&#125;-)" style="font-size:114%;margin:0 4em"><a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D0%B4%D0%B5%D0%BF%D1%80%D0%B5%D1%81%D0%B8%D0%B2" title="Антидепресив">Antidepresivi</a> (<a href="/wiki/ATC_kod_N06#N06A" title="ATC kod N06">N06A</a>)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Specifični_inhibitori_preuzimanja_(-&#123;RI&#125;-),_pojačivači_(-&#123;RE&#125;-),_i_agensi_oslobađanja_(-&#123;RA&#125;-)" style="font-size:114%;margin:0 4em">Specifični <a href="/wiki/Inhibitor_preuzimanja" title="Inhibitor preuzimanja">inhibitori</a> <a href="/wiki/Neuronsko_preuzimanje" title="Neuronsko preuzimanje">preuzimanja</a> (RI), <a href="/wiki/Poja%C4%8Diva%C4%8Di_preuzimanja" class="mw-redirect" title="Pojačivači preuzimanja">pojačivači</a> (RE), i <a href="/wiki/Agensi_osloba%C4%91anja_neurotransmitera" class="mw-redirect" title="Agensi oslobađanja neurotransmitera">agensi oslobađanja</a> (RA)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Selektivni_inhibitor_preuzimanja_serotonina" title="Selektivni inhibitor preuzimanja serotonina">Selektivni inhibitori preuzimanja serotonina</a> (SSRI)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Alaproklat" title="Alaproklat">Alaproklat</a> • <a href="/wiki/Citalopram" title="Citalopram">Citalopram</a> • <a href="/wiki/Escitalopram" title="Escitalopram">Escitalopram</a> • <a href="/wiki/Femoksetin" title="Femoksetin">Femoksetin</a> • <a href="/wiki/Fluoksetin" title="Fluoksetin">Fluoksetin</a><sup>#</sup> • <a href="/wiki/Fluvoksamin" title="Fluvoksamin">Fluvoksamin</a> • <a href="/wiki/Indalpin" title="Indalpin">Indalpin</a> • <a href="/wiki/Ifoksetin" title="Ifoksetin">Ifoksetin</a> • <a href="/wiki/Litoksetin" title="Litoksetin">Litoksetin</a> • <a href="/wiki/Lubazodon" title="Lubazodon">Lubazodon</a> • <a href="/wiki/Panuramin" title="Panuramin">Panuramin</a> • <a href="/wiki/Paroksetin" title="Paroksetin">Paroksetin</a> • <a href="/wiki/Pirandamin" title="Pirandamin">Pirandamin</a> • <a href="/wiki/Seproksetin" title="Seproksetin">Seproksetin</a> • <a href="/wiki/Sertralin" title="Sertralin">Sertralin</a><sup>#</sup> • <a href="/wiki/Vilazodon" title="Vilazodon">Vilazodon</a> • <a href="/wiki/Zimelidin" title="Zimelidin">Zimelidin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Inhibitor_preuzimanja_serotonin-norepinefrina" title="Inhibitor preuzimanja serotonin-norepinefrina">Inhibitori preuzimanja serotonin-norepinefrina</a> (SNRI)</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Bicifadin" title="Bicifadin">Bicifadin</a> • <a href="/wiki/Klovoksamin" title="Klovoksamin">Klovoksamin</a> • <a href="/wiki/Desvenlafaksin" title="Desvenlafaksin">Desvenlafaksin</a> • <a href="/wiki/Duloksetin" title="Duloksetin">Duloksetin</a> • <a href="/wiki/Levomilnacipran" title="Levomilnacipran">Levomilnacipran</a> • <a href="/wiki/Eklanamin" title="Eklanamin">Eklanamin</a> • <a href="/wiki/Milnacipran" title="Milnacipran">Milnacipran</a> • <a href="/wiki/Sibutramin" title="Sibutramin">Sibutramin</a> • <a href="/wiki/Venlafaksin" title="Venlafaksin">Venlafaksin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Inhibitor_preuzimanja_serotonin-norepinefrin-dopamina" title="Inhibitor preuzimanja serotonin-norepinefrin-dopamina">Inhibitori preuzimanja serotonin-norepinefrin-dopamina</a> (SNDRI)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Brazofensin" class="mw-redirect" title="Brazofensin">Brazofensin</a> • <a href="/wiki/BTS-74,398" class="mw-redirect" title="BTS-74,398">BTS-74,398</a> • <a href="/wiki/%D0%9A%D0%BE%D0%BA%D0%B0%D0%B8%D0%BD" title="Кокаин">Kokain</a> • <a href="/wiki/Diklofensin" class="mw-redirect" title="Diklofensin">Diklofensin</a> • <a href="/wiki/DOV-21,947" class="mw-redirect" title="DOV-21,947">DOV-21,947</a> • <a href="/wiki/DOV-102,677" title="DOV-102,677">DOV-102,677</a> • <a href="/wiki/DOV-216,303" title="DOV-216,303">DOV-216,303</a> • <a href="/wiki/EXP-561" title="EXP-561">EXP-561</a> • <a href="/wiki/Fezolamin" title="Fezolamin">Fezolamin</a> • <a href="/wiki/JNJ-7,925,476" class="mw-redirect" title="JNJ-7,925,476">JNJ-7,925,476</a> • <a href="/wiki/NS-2359" title="NS-2359">NS-2359</a> • <a href="/wiki/PRC200-SS" class="mw-redirect" title="PRC200-SS">PRC200-SS</a> • <a href="/wiki/Pridefrin" class="mw-redirect" title="Pridefrin">Pridefrin</a> • <a href="/wiki/SEP-225,289" class="mw-redirect" title="SEP-225,289">SEP-225,289</a> • SEP-227,162 • <a href="/wiki/Tezofensin" class="mw-redirect" title="Tezofensin">Tezofensin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Inhibitori_preuzimanja_norepinefrina" class="mw-redirect" title="Inhibitori preuzimanja norepinefrina">Inhibitori preuzimanja norepinefrina</a> (NRI)</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Amedalin" title="Amedalin">Amedalin</a> • <a href="/wiki/Atomoksetin" title="Atomoksetin">Atomoksetin/Tomoksetin</a> • <a href="/wiki/Binedalin" title="Binedalin">Binedalin</a> • <a href="/wiki/Ciklazindol" title="Ciklazindol">Ciklazindol</a> • <a href="/wiki/Daledalin" title="Daledalin">Daledalin</a> • <a href="/wiki/Esreboksetin" title="Esreboksetin">Esreboksetin</a> • <a href="/wiki/Lortalamin" title="Lortalamin">Lortalamin</a> • <a href="/wiki/Mazindol" title="Mazindol">Mazindol</a> • <a href="/wiki/Nisoksetin" class="mw-redirect" title="Nisoksetin">Nisoksetin</a> • <a href="/wiki/Reboksetin" title="Reboksetin">Reboksetin</a> • <a href="/wiki/Talopram" title="Talopram">Talopram</a> • <a href="/wiki/Talsupram" title="Talsupram">Talsupram</a> • <a href="/wiki/Tandamin" title="Tandamin">Tandamin</a> • <a href="/wiki/Viloksazin" title="Viloksazin">Viloksazin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Inhibitor_preuzimanja_dopamina" title="Inhibitor preuzimanja dopamina">Inhibitori preuzimanja dopamina</a> (DRI)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Medifoksamin" title="Medifoksamin">Medifoksamin</a> • <a href="/wiki/Vanokserin" title="Vanokserin">Vanokserin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Inhibitor_preuzimanja_norepinefrin-dopamina" title="Inhibitor preuzimanja norepinefrin-dopamina">Inhibitori preuzimanja norepinefrin-dopamina</a> (NDRI)</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Amineptin" title="Amineptin">Amineptin</a> • <a href="/wiki/Bupropion" title="Bupropion">Bupropion/Amfebutamon</a><sup>#</sup> • <a href="/wiki/Cilobamin" title="Cilobamin">Cilobamin</a> • <a href="/wiki/Manifaksin" title="Manifaksin">Manifaksin</a> • <a href="/wiki/Metilfenidat" title="Metilfenidat">Metilfenidat</a> • <a href="/wiki/Nomifensin" title="Nomifensin">Nomifensin</a> • <a href="/wiki/Radafaksin" title="Radafaksin">Radafaksin</a> • <a href="/wiki/Tametralin" title="Tametralin">Tametralin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Agens_osloba%C4%91anja_norepinefrin-dopamina" title="Agens oslobađanja norepinefrin-dopamina">Agensi oslobađanja norepinefrin-dopamina</a> (NDRA)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/%D0%90%D0%BC%D1%84%D0%B5%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Амфетамин">Amfetamin</a> • <a href="/wiki/Befuralin" title="Befuralin">Befuralin</a> • <a href="/wiki/Lisdeksamfetamin" title="Lisdeksamfetamin">Lisdeksamfetamin</a> • <a href="/wiki/%D0%9C%D0%B5%D1%82%D0%B0%D0%BC%D1%84%D0%B5%D1%82%D0%B0%D0%BC%D0%B8%D0%BD" title="Метамфетамин">Metamfetamin</a> • <a href="/wiki/Fenetilamin" title="Fenetilamin">Fenetilamin</a> • <a href="/wiki/Piberalin" title="Piberalin">Piberalin</a> • <a href="/wiki/Tranilcipromin" title="Tranilcipromin">Tranilcipromin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Agens_osloba%C4%91anja_serotonin-norepinefrin-dopamina" title="Agens oslobađanja serotonin-norepinefrin-dopamina">Agensi oslobađanja serotonin-norepinefrin-dopamina</a> (SNDRA)</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/4-Me-%CE%B1MT" title="4-Me-αMT">4-Metil-αMT</a> • <a href="/wiki/Alfa-Etiltriptamin" title="Alfa-Etiltriptamin">αET/Etriptamin</a> • <a href="/wiki/Alfa-Methiltriptamin" class="mw-redirect" title="Alfa-Methiltriptamin">αMT/Metriptamin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Selektivni_poja%C4%8Diva%C4%8D_preuzimanja_serotonina" class="mw-redirect" title="Selektivni pojačivač preuzimanja serotonina">Selektivni pojačivači preuzimanja serotonina</a> (SSRE)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Tianeptin" title="Tianeptin">Tianeptin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small>Drugi</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Indeloksazin" title="Indeloksazin">Indeloksazin</a> • <a href="/wiki/%D0%A2%D1%80%D0%B0%D0%BC%D0%B0%D0%B4%D0%BE%D0%BB" title="Трамадол">Tramadol</a> • <a href="/wiki/Viqualin" class="mw-redirect" title="Viqualin">Viqualin</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Antagonisti_i/ili_inhibitori" style="font-size:114%;margin:0 4em"><a href="/wiki/Antagonist_(farmakologija)" title="Antagonist (farmakologija)">Antagonisti</a> i/ili <a href="/wiki/Inhibitor_preuzimanja" title="Inhibitor preuzimanja">inhibitori</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Antagonisti_serotonina_i_inhibitori_ponovnog_uzimanja" title="Antagonisti serotonina i inhibitori ponovnog uzimanja">Serotoninski antagonisti i inhibitori ponovnog preuzimanja</a> (SARI)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Etoperidon" title="Etoperidon">Etoperidon</a> • <a href="/wiki/Nefazodon" title="Nefazodon">Nefazodon</a> • <a href="/wiki/Trazodon" title="Trazodon">Trazodon</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Noradrenergi%C4%8Dki_i_specifi%C4%8Dni_serotonergi%C4%8Dki_antidepresant" title="Noradrenergički i specifični serotonergički antidepresant">Noradrenergički i specifični serotonergički antidepresanti</a> (NaSSA)</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Aptazapin" title="Aptazapin">Aptazapin</a> • <a href="/wiki/Esmirtazapin" title="Esmirtazapin">Esmirtazapin</a> • <a href="/wiki/Mianserin" class="mw-redirect" title="Mianserin">Mianserin</a> • <a href="/wiki/Mirtazapin" title="Mirtazapin">Mirtazapin</a> • <a href="/wiki/Setiptilin" title="Setiptilin">Setiptilin/Teciptilin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Norepinefrin-dopaminski_disinhibitor" title="Norepinefrin-dopaminski disinhibitor">Norepinefrin-dopaminski disinhibitori</a> (NDDI)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Agomelatin" title="Agomelatin">Agomelatin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small>Serotoninski modulatori i stimulatori (SMS)</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Lu_AA21004" class="mw-redirect" title="Lu AA21004">Lu AA21004</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Triciklični_i_tetraciklični_antidepresivi_(-&#123;TCA/TeCA&#125;-)" style="font-size:114%;margin:0 4em"><a href="/wiki/Tricikli%C4%8Dni_antidepresiv" title="Triciklični antidepresiv">Triciklični</a> i <a href="/wiki/Tetracikli%C4%8Dni_antidepresiv" title="Tetraciklični antidepresiv">tetraciklični antidepresivi</a> (TCA/TeCA)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Tricikli%C4%8Dni_antidepresiv" title="Triciklični antidepresiv">Triciklici</a></small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Amezepin" title="Amezepin">Amezepin</a> • <a href="/wiki/Amineptin" title="Amineptin">Amineptin</a> • <a href="/wiki/Amitriptilin" title="Amitriptilin">Amitriptilin</a><sup>#</sup> • <a href="/wiki/Amitriptilinoksid" title="Amitriptilinoksid">Amitriptilinoksid</a> • <a href="/wiki/Azepindol" title="Azepindol">Azepindol</a> • <a href="/wiki/Butriptilin" title="Butriptilin">Butriptilin</a> • <a href="/wiki/Cianopramin" class="mw-redirect" title="Cianopramin">Cianopramin</a> • <a href="/wiki/Klomipramin" title="Klomipramin">Klomipramin</a> • <a href="/wiki/Kotriptilin" title="Kotriptilin">Kotriptilin</a> • <a href="/w/index.php?title=Cianodotiepin&action=edit&redlink=1" class="new" title="Cianodotiepin (страница не постоји)">Cianodotiepin</a> • <a href="/wiki/Demeksiptilin" title="Demeksiptilin">Demeksiptilin</a> • <a href="/wiki/Depramin" title="Depramin">Depramin</a>/<a href="/w/index.php?title=Balipramin&action=edit&redlink=1" class="new" title="Balipramin (страница не постоји)">Balipramin</a> • <a href="/wiki/Desipramin" title="Desipramin">Desipramin</a> • <a href="/wiki/Dibenzepin" title="Dibenzepin">Dibenzepin</a> • <a href="/wiki/Dimetakrin" title="Dimetakrin">Dimetakrin</a> • <a href="/wiki/Dosulepin" title="Dosulepin">Dosulepin/Dotiepin</a> • <a href="/wiki/Doksepin" title="Doksepin">Doksepin</a> • <a href="/wiki/Enprazepin" title="Enprazepin">Enprazepin</a> • <a href="/wiki/Fluotracen" title="Fluotracen">Fluotracen</a> • <a href="/wiki/Hepzidin" title="Hepzidin">Hepzidin</a> • <a href="/wiki/Homopipramol" title="Homopipramol">Homopipramol</a> • <a href="/wiki/Imipramin" title="Imipramin">Imipramin</a> • <a href="/wiki/Imipraminoksid" title="Imipraminoksid">Imipraminoksid</a> • <a href="/wiki/Intriptilin" title="Intriptilin">Intriptilin</a> • <a href="/wiki/Iprindol" title="Iprindol">Iprindol</a> • <a href="/wiki/Ketipramin" title="Ketipramin">Ketipramin</a> • <a href="/wiki/Litracen" title="Litracen">Litracen</a> • <a href="/wiki/Lofepramin" title="Lofepramin">Lofepramin</a> • <a href="/wiki/Losindol" title="Losindol">Losindol</a> • <a href="/wiki/Mariptilin" title="Mariptilin">Mariptilin</a> • <a href="/wiki/Melitracen" title="Melitracen">Melitracen</a> • <a href="/wiki/Metapramin" title="Metapramin">Metapramin</a> • <a href="/wiki/Mezepin" title="Mezepin">Mezepin</a> • <a href="/wiki/Naranol" title="Naranol">Naranol</a> • <a href="/wiki/Nitroksazepin" title="Nitroksazepin">Nitroksazepin</a> • <a href="/wiki/Nortriptilin" title="Nortriptilin">Nortriptilin</a> • <a href="/wiki/Noksiptilin" title="Noksiptilin">Noksiptilin</a> • <a href="/w/index.php?title=Octriptilin&action=edit&redlink=1" class="new" title="Octriptilin (страница не постоји)">Octriptilin</a> • <a href="/wiki/Opipramol" title="Opipramol">Opipramol</a> • <a href="/wiki/Pipofezin" title="Pipofezin">Pipofezin</a> • <a href="/wiki/Propizepin" title="Propizepin">Propizepin</a> • <a href="/wiki/Protriptilin" title="Protriptilin">Protriptilin</a> • <a href="/w/index.php?title=Kinupramin&action=edit&redlink=1" class="new" title="Kinupramin (страница не постоји)">Kinupramin</a> • <a href="/wiki/Tampramin" title="Tampramin">Tampramin</a> • <a href="/wiki/Tianeptin" title="Tianeptin">Tianeptin</a> • <a href="/wiki/Tienopramin" title="Tienopramin">Tienopramin</a> • <a href="/wiki/Trimipramin" title="Trimipramin">Trimipramin</a>;</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small><a href="/wiki/Tetracikli%C4%8Dni_antidepresiv" title="Tetraciklični antidepresiv">Tetraciklici</a></small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/7-Hidroksiamoksapin" title="7-Hidroksiamoksapin">7-OH-Amoksapin</a> • <a href="/wiki/Amoksapin" title="Amoksapin">Amoksapin</a> • <a href="/wiki/Aptazapin" title="Aptazapin">Aptazapin</a> • <a href="/wiki/Azipramin" title="Azipramin">Azipramin</a> • <a href="/wiki/Ciklazindol" title="Ciklazindol">Ciklazindol</a> • <a href="/wiki/Ciklopramin" title="Ciklopramin">Ciklopramin</a> • <a href="/wiki/Esmirtazapin" title="Esmirtazapin">Esmirtazapin</a> • <a href="/wiki/Loksapin" title="Loksapin">Loksapin</a> • <a href="/wiki/Maprotilin" title="Maprotilin">Maprotilin</a> • <a href="/wiki/Mazindol" title="Mazindol">Mazindol</a> • <a href="/wiki/Mianserin" class="mw-redirect" title="Mianserin">Mianserin</a> • <a href="/wiki/Mirtazapin" title="Mirtazapin">Mirtazapin</a> • <a href="/wiki/Oksaprotilin" title="Oksaprotilin">Oksaprotilin</a> • <a href="/wiki/Setiptilin" title="Setiptilin">Setiptilin/Teciptilin</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Inhibitori_monoamin_oksidaze_(-&#123;MAOI&#125;-)" style="font-size:114%;margin:0 4em"><a href="/wiki/Inhibitor_monoamin_oksidaze" class="mw-redirect" title="Inhibitor monoamin oksidaze">Inhibitori monoamin oksidaze</a> (MAOI)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><small>Neselektivni</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><i>Ireverzibilni:</i> <a href="/wiki/Benmoksin" title="Benmoksin">Benmoksin</a> • <a href="/wiki/Echinopsidin" class="mw-redirect" title="Echinopsidin">Echinopsidin</a> • <a href="/wiki/Iproklozid" title="Iproklozid">Iproklozid</a> • <a href="/wiki/Iproniazid" title="Iproniazid">Iproniazid</a> • <a href="/w/index.php?title=Isokarboksazid&action=edit&redlink=1" class="new" title="Isokarboksazid (страница не постоји)">Isokarboksazid</a> • <a href="/wiki/Mebanazin" title="Mebanazin">Mebanazin</a> • <a href="/wiki/Metfendrazin" title="Metfendrazin">Metfendrazin</a> • <a href="/wiki/Nialamid" title="Nialamid">Nialamid</a> • <a href="/wiki/Oktamoksin" title="Oktamoksin">Oktamoksin</a> • <a href="/wiki/Fenelzin" title="Fenelzin">Fenelzin</a> • <a href="/wiki/Feniprazin" title="Feniprazin">Feniprazin</a> • <a href="/wiki/Fenoksipropazin" title="Fenoksipropazin">Fenoksipropazin</a> • <a href="/wiki/Pivalilbenzhidrazin" title="Pivalilbenzhidrazin">Pivalilbenzhidrazin</a> • <a href="/wiki/Safrazin" title="Safrazin">Safrazin</a> • <a href="/wiki/Tranilcipromin" title="Tranilcipromin">Tranilcipromin</a>; <i>Reverzibilni:</i> <a href="/wiki/Karoksazon" title="Karoksazon">Karoksazon</a> • <a href="/wiki/Paraksazon" title="Paraksazon">Paraksazon</a>;</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small>MAO<sub>A</sub>-Selektivni</small></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><i>Ireverzibilni:</i> <a href="/wiki/Klorgilin" title="Klorgilin">Klorgilin</a>; <i>Reverzibilni:</i> <a href="/wiki/Amiflamin" title="Amiflamin">Amiflamin</a> • <a href="/wiki/Bazinaprin" title="Bazinaprin">Bazinaprin</a> • <a href="/wiki/Befloksaton" title="Befloksaton">Befloksaton</a> • <a href="/wiki/Befol" class="mw-disambig" title="Befol">Befol</a> • <a href="/wiki/Brofaromin" title="Brofaromin">Brofaromin</a> • <a href="/wiki/Cimoksaton" title="Cimoksaton">Cimoksaton</a> • <a href="/w/index.php?title=Esuperon&action=edit&redlink=1" class="new" title="Esuperon (страница не постоји)">Esuperon</a> • <a href="/wiki/Harmala_alkaloid" title="Harmala alkaloid">Harmala Alkaloidi</a> (<a href="/wiki/Harmin" title="Harmin">Harmin</a>, <a href="/wiki/Harmalin" title="Harmalin">Harmalin</a>, <a href="/wiki/Tetrahidroharmin" title="Tetrahidroharmin">Tetrahidroharmin</a>, <a href="/wiki/Harmala_alkaloid#Hemijske_Forme" title="Harmala alkaloid">Harman</a>, <a href="/w/index.php?title=Norharman&action=edit&redlink=1" class="new" title="Norharman (страница не постоји)">Norharman</a>, itd) • <a href="/w/index.php?title=Metilen_plavo&action=edit&redlink=1" class="new" title="Metilen plavo (страница не постоји)">Metilen plavo</a> • <a href="/wiki/Metralindol" title="Metralindol">Metralindol</a> • <a href="/wiki/Minaprin" title="Minaprin">Minaprin</a> • <a href="/wiki/Moklobemid" title="Moklobemid">Moklobemid</a> • <a href="/wiki/Pirlindol" title="Pirlindol">Pirlindol</a> • <a href="/wiki/Serkloremin" title="Serkloremin">Serkloremin</a> • <a href="/wiki/Tetrindol" title="Tetrindol">Tetrindol</a> • <a href="/wiki/Toloksaton" title="Toloksaton">Toloksaton</a> • <a href="/wiki/%D0%A2%D0%B8%D1%80%D0%B8%D0%BC%D0%B0" title="Тирима">Tirima</a>;</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><small>MAO<sub>B</sub>-Selektivni</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><i>Ireverzibilni:</i> <a href="/wiki/Ladostigil" title="Ladostigil">Ladostigil</a> • <a href="/wiki/Mofegilin" title="Mofegilin">Mofegilin</a> • <a href="/wiki/Pargilin" title="Pargilin">Pargilin</a> • <a href="/wiki/Rasagilin" title="Rasagilin">Rasagilin</a> • <a href="/wiki/Selegilin" title="Selegilin">Selegilin</a>; <i>Reverzibilni:</i> <a href="/wiki/Lazabemid" title="Lazabemid">Lazabemid</a> • <a href="/wiki/Milacemid" title="Milacemid">Milacemid</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Azapironi_i_drugi_agonisti_-&#123;5-HT1A&#125;-_receptora" style="font-size:114%;margin:0 4em"><a href="/wiki/Azapiron" title="Azapiron">Azapironi</a> i drugi <a href="/wiki/Agonist_serotoninskog_receptora" title="Agonist serotoninskog receptora">agonisti</a> <a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT<sub>1A</sub> receptora</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Alnespiron" title="Alnespiron">Alnespiron</a> • <a href="/wiki/Aripiprazol" title="Aripiprazol">Aripiprazol</a> • <a href="/wiki/Befiradol" title="Befiradol">Befiradol</a> • <a href="/wiki/Buspiron" title="Buspiron">Buspiron</a> • <a href="/wiki/Eptapiron" title="Eptapiron">Eptapiron</a> • <a href="/wiki/Flesinoksan" title="Flesinoksan">Flesinoksan</a> • <a href="/wiki/Flibanserin" class="mw-redirect" title="Flibanserin">Flibanserin</a> • <a href="/wiki/Gepiron" title="Gepiron">Gepiron</a> • <a href="/wiki/Ipsapiron" title="Ipsapiron">Ipsapiron</a> • <a href="/wiki/Oksaflozan" title="Oksaflozan">Oksaflozan</a> • <a href="/wiki/Tandospiron" title="Tandospiron">Tandospiron</a> • <a href="/wiki/Vilazodon" title="Vilazodon">Vilazodon</a> • <a href="/wiki/Zalospiron" title="Zalospiron">Zalospiron</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Преузето из „<a dir="ltr" href="https://sr.wikipedia.org/w/index.php?title=Antagonisti_NK1_receptora&oldid=26727930">https://sr.wikipedia.org/w/index.php?title=Antagonisti_NK1_receptora&oldid=26727930</a>”</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%9A%D0%B0%D1%82%D0%B5%D0%B3%D0%BE%D1%80%D0%B8%D1%98%D0%B5" 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