CINXE.COM

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about="/products/proteins" typeof="sioc:Item foaf:Document"> <header> <span property="dc:title" content="Recombinant Proteins" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> </header> <div class="required-fields group-hero-image-wrapper field-group-html-element"><div class="field field-name-field-hero-image field-type-et-image-field field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="//resources.rndsystems.com/images/site/recombinant-proteins-header.jpg?v=1" class="et-image-image" title="recombinant proteins" alt="recombinant proteins" /> </div> </div></div></div></div><div class="product-category-search-wrapper col-xs-12 col-sm-8 col-md-9 col-lg-9 col-xl-9"><h2 class="group-search-title-wrapper field-group-html-element"><div class="field field-name-field-search-title field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Search Recombinant Proteins</div></div></div></h2><div class="group-search-wrapper field-group-div"><div class="field field-name-field-pre-faceted-search field-type-et-faceted-search field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <form action="/search" class="form-inline" method="get" id="faceted_search_bar"> <div class="form-group keyword-input"> <input type="hidden" name="category" value="Proteins and Enzymes"> <input id="pc_facet" type="textfield" name="keywords" placeholder="Keywords"/> </div> <select id="pc_species" name="species"> <option value="*">All Species</option> <option value="Human">Human</option> <option value="Mouse">Mouse</option> <option value="Rat">Rat</option> <option value="Canine">Canine</option> </select> <input type="submit" name="submit" value="Search" id="pc_submit" class="btn 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.group-hero-image-wrapper {margin:0 0 20px;} </style> <div id="recombinant-proteins" name="recombinant-proteins"> <div class="row"> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/products/rd-systems-cytokines-growth-factors"><img alt="Cytokines and Growth Factors" class="img-responsive center-block" src="//resources.rndsystems.com/images/site/rec-cytokines-growth-factors-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/products/rd-systems-cytokines-growth-factors"><strong>Cytokines and<br /> Growth Factors</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/products/good-manufacturing-practices-gmp-grade-proteins"><img alt="GMP Proteins" class="img-responsive center-block" src="//resources.rndsystems.com/images/site/rec-gmp-proteins-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/products/good-manufacturing-practices-gmp-grade-proteins"><strong>GMP<br /> Proteins</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/products/immunotherapy-purified-proteins-immunotherapy-research-and-clinical-manufacturing"><img alt="Immune Checkpoint Proteins" class="img-responsive center-block" src="//resources.rndsystems.com/images/site/rec-immune-checkpoint-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/products/immunotherapy-purified-proteins-immunotherapy-research-and-clinical-manufacturing"><strong>Immune Checkpoint<br /> Proteins</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/products/active-biotinylated-proteins"><img alt="Avi-tag Biotinylated Proteins" class="img-responsive center-block" src="//resources.rndsystems.com/images/site/rec-avi-tag-biotinylated-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/products/active-biotinylated-proteins"><strong>Avi-tag Biotinylated<br /> Proteins</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/products/enzymes"><img alt="Enzymes" class="img-responsive center-block" src="//resources.rndsystems.com/images/site/rec-enzymes-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/products/enzymes"><strong>Enzymes</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/services/bulk-quote-request"><img alt="Bulk Proteins" class="img-responsive center-block" src="//resources.rndsystems.com/images/site/rec-bulk-proteins-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/services/bulk-quote-request"><strong>Bulk<br /> Proteins</strong></a></p> </div> </div> </div> </div> </div> <p> </p> </div></div></div></p></div> </div> </div> </div></div></div></div> </div><div class="group-basic-video field-group-div"> <div class="paragraphs-items paragraphs-items-field-basic-paragraph paragraphs-items-field-basic-paragraph-full paragraphs-items-full"> <div class="field field-name-field-basic-paragraph field-type-paragraphs field-label-hidden"><div class="field-items"><div class="field-item even"><div class="entity entity-paragraphs-item paragraphs-item-title-and-basic-html" about="" typeof=""> <div class="content"> <div class="group-basic-div field-group-div"><p class="group-desc field-group-html-element"><div class="field field-name-field-teaser-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><h2 style="margin-top: 30px"><a href="/products/rd-systems-cytokines-growth-factors">Cytokines and Growth Factors</a></h2> <p>With over 30 years of experience developing and manufacturing recombinant proteins for cytokine and growth factor research, our stringent purification and production standards ensure that our proteins display the highest levels of bioactivity and purity, low endotoxin levels, and lot-to-lot consistency.</p> <h2 style="margin-top: 30px"><a href="/products/good-manufacturing-practices-gmp-grade-proteins">GMP Proteins</a></h2> <p>Manufactured under guidelines that allow for their use as ancillary materials in cell therapy or further manufacturing processes, GMP-grade cytokines and growth factors come with extensive documentation to provide cell therapy researchers with a consistent, fully transparent, and traceable source of reagents.</p> <p><a class="btn btn-primary" href="https://calendly.com/cell-and-gene-therapy-specialists/lets-talk-gmp-1" target="_blank">Let’s talk GMP</a></p> <h2 style="color: rgb(55, 55, 55); margin-top: 30px;"><a href="/products/animal-free-recombinant-proteins">Animal-Free RUO Proteins</a></h2> <p>For researchers who need defined culture conditions, for those whose preclinical work has the potential of progressing to clinical trials, or for those concerned with animal components due to ethical or regulatory issues, we offer Animal-Free RUO proteins. Our Animal-Free RUO proteins are produced using identical expression systems and manufacturing methods as our Animal-Free GMP-Grade proteins.</p> <h2 style="color: rgb(55, 55, 55); margin-top: 30px;"><a href="/product-highlights/proteins-for-stem-cell-culture">Proteins for Stem Cell Culture</a></h2> <p>Achieve robust, reproducible stem cell cultures with R&D Systems proteins. Our proteins provide high levels of bioactivity and lot-to-lot consistency to promote optimal stem cell expansion and differentiation, with minimal variability between cultures.</p> <h2 style="margin-top: 30px"><a href="/products/immunotherapy-purified-proteins-immunotherapy-research-and-clinical-manufacturing">Immune Checkpoint Proteins</a></h2> <p>Take advantage of our wide range of bioactive recombinant immune checkpoint proteins. From common targets like PD-L1 and CTLA-4 to emerging targets such as butyrophilins and LILRB receptors, we offer a variety of tags and species for studying immune checkpoints.</p> <h2 style="color: rgb(55, 55, 55); margin-top: 30px;"><a href="/products/proteins-coronavirus-research">Proteins for Coronavirus Research</a></h2> <p>View our proteins and enzymes for researching SARS-CoV-2 and other coronaviruses. Our growing list includes spike proteins, papain-like proteases, 3CL proteases and the SARS-Cov-2 nucleocapsid protein. If <a href="/services/bulk-quote-request">bulk quantities</a> or <a href="/services/protein-services/proteins-in-a-plate">proteins prepared in a plate</a> will help with your research, we are happy to explore options and we welcome your request for a quote!</p> <h2 style="margin-top: 30px"><a href="/products/active-biotinylated-proteins">Avi-tag and Amine-Labeled Biotinylated Proteins</a></h2> <p>Explore our expanding catalog of Avi-tag and amine-labeled biotinylated proteins. Our rigorous quality standards ensure that all of our biotinylated proteins display the same level of bioactivity as their unlabeled counterparts and exhibit minimal lot-to-lot variability, so they provide you with the performance and the consistency that you need to optimize your assay.</p> <h2 style="margin-top: 30px"><a href="/product-highlights/fluorescent-labeled-recombinant-proteins">Fluorokines™ Fluorescent-labeled Recombinant Proteins</a></h2> <p>Utilize our wide selection of fluorescent-labeled recombinant proteins to evaluate the expression of specific chimeric antigen receptors (CARs) on CAR-T or CAR-NK cells, detect cells expressing specific immune checkpoint receptors, or assess SARS-CoV-2 sensitive ACE-2+ cells or immune responses. Fluorescent-labeled proteins allow target cells to be directly stained and detected by flow cytometry.</p> <h2 style="margin-top: 30px"><a href="/products/enzymes">Enzymes</a></h2> <p>From proteases and bioprocessing enzymes to glycobiology- and ubiquitin-related enzymes, we offer a large selection of enzymes for various applications. Additionally, we provide a range of enzyme inhibitors, substrates, and enzyme activity kits to further your research.</p> <p> </p> <h2><a href="/fluorescent-glycan-labeling-and-detection">Fluorescent Glycan Labeling and Detection Reagents</a></h2> <p>Explore our reagents for Fluorescent Glycan Labeling and Detection. We provide kits and individually packaged labeling enzymes and fluorescent-labeled donor substrates that make it possible to label and detect glycans using SDS-PAGE and a fluorescence imaging system.</p> <h2 style="margin-top: 30px"><a href="/products/ubiquitin-related-products">Ubiquitin Related Products</a></h2> <p>Formerly Boston Biochem, R&D Systems is the worldwide leader in providing quality ubiquitin and ubiquitin-related products for targeted protein degradation and ubiquitin proteasome research.</p> <h2 style="margin-top: 30px"><a href="/services/protein-services">Custom Protein Services</a></h2> <p>If you don’t see what you need listed on our website, contact us. From scratch protein development to customizing a protein that we already offer, our custom services team will create the protein that fits your experimental needs.</p> <h2 style="margin-top: 30px"><a href="/services/proteins-beyond-our-catalog">Proteins Beyond Our Catalog</a></h2> <p>Only a fraction of the recombinant proteins we make end up as products. We have amassed a huge library of non-catalog proteins that are in stock and available to the customer. <a href="/services/proteins-beyond-our-catalog">Learn more about our available proteins</a>.</p> <h2 style="margin-top: 30px"><a href="/services/bulk-quote-request">Bulk Proteins</a></h2> <p>Are you in need of large quantities of a particular protein? Contact us for a bulk quote. We have the capacity and expertise to scale up the production of any protein to meet your needs, and we offer economical pricing on bulk orders.</p> <h4 style="margin-top: 30px">How are recombinant proteins made?</h4> <p>Recombinant proteins are made using an engineered DNA sequence that contains genetic instructions to synthesize the protein of interest. This DNA is delivered to a host cell where the cell’s internal machinery is used to synthesize the recombinant protein. The cells are cultured at scale to increase production, and then the recombinant protein is purified.</p> <p>R&D Systems’ rich history in the recombinant protein industry began over 30 years ago. Today, we are fast approaching 5000 recombinant proteins. Our stringent quality control specifications lead to industry-leading bioactivity and lot-to-lot consistency. R&D Systems proteins are the most cited proteins in the scientific literature. Today, we continue to innovate so that we can provide the research community with the best proteins on the market.</p> <h2 style="margin-top: 30px">Additional Resources:</h2> <p style="margin-top: 30px"><a href="/resources/faqs/proteins-and-enzymes">Proteins and Enzymes Frequently Asked Questions</a></p> <p><a href="/resources/technical-information/unit-conversion-table">Unit conversion table</a></p> <p><a href="/products/recombinant-protein-quality">Quality Control</a></p> <p><a href="https://www.bio-techne.com/gmp-capabilities" target="_blank">GMP Capabilities at Bio-Techne</a></p> <p><a href="/services/bioactivity-testing-services">Bioassay Testing Services</a></p> <p><a href="/resources/calculators">Molarity and Reconstitution Calculators</a></p> <p style="margin-bottom: 30px"><a href="/services/protein-services/proteins-in-a-plate">Proteins in a Plate for High Throughput Screening</a></p> </div></div></div></p></div> </div> </div> </div></div></div></div> </div></div><div class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3 group-featured-content-wrapper field-group-div"><h2 class="field-group-html-element"><div class="field field-name-field-featured-content-title field-type-text field-label-hidden"><div class="field-items"><div class="field-item even"> Featured Content</div></div></div></h2> <div class="paragraphs-items paragraphs-items-field-featured-content paragraphs-items-field-featured-content-full paragraphs-items-full"> <div class="field field-name-field-featured-content field-type-paragraphs field-label-hidden"><div class="field-items"><div class="field-item even"><div class="entity entity-paragraphs-item paragraphs-item-featured-content" about="" typeof=""> <div class="content"> <div class="collapsible group-featured-content field-group-div m-featured-product speed-fast effect-none"> <h3><span class="field-group-format-toggler">Featured Content</span></h3> <div class="field-group-format-wrapper" style="display: block;"><h4 class="group-title-wrapper field-group-html-element"><div class="field field-name-field-featured-title field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.bio-techne.com/resources/literature/development-of-il2-heat-stable-agonist-protein-using-artificial-intelligence" target="_blank">Application Note: Development of an AI Modified IL-2 Heat Stable Agonist Protein</a></div></div></div></h4><div class="required-fields group-img-wrapper field-group-html-element"><div class="field field-name-field-img field-type-et-image-field field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="https://resources.rndsystems.com/images/products/aim-homepage-featured-box-750x471.jpg" class="et-image-image" alt=" IL-2 protein ribbon structure shown on top of a computer circuit board with a thumbnail of the IL-2 Heat Stable Agonist Protein Application Note" /> </div> </div></div></div></div><p class="group-featured-content-text field-group-html-element"><div class="field field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Explore the benefits of IL-2 Heat Stable Agonist Protein, which can withstand high temperatures and extended culture durations.</div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.bio-techne.com/resources/literature/development-of-il2-heat-stable-agonist-protein-using-artificial-intelligence" target="_blank">View Application Note</a></div></div></div></div></div></div> </div> </div> </div><div class="field-item odd"><div class="entity entity-paragraphs-item paragraphs-item-featured-content" about="" typeof=""> <div class="content"> <div class="collapsible group-featured-content field-group-div m-featured-product speed-fast effect-none"> <h3><span class="field-group-format-toggler">Featured Content</span></h3> <div class="field-group-format-wrapper" style="display: block;"><h4 class="group-title-wrapper field-group-html-element"><div class="field field-name-field-featured-title field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.bio-techne.com/reagents/proteins/sec-mals" target="_blank">SEC-MALS for Protein Characterization</a></div></div></div></h4><div class="required-fields group-img-wrapper field-group-html-element"><div class="field field-name-field-img field-type-et-image-field field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="//resources.rndsystems.com/images/banners/sec-mals-banner-478x300.jpg" class="et-image-image" title="Magnified 3D purple image of a protein molecule on a blue background. " alt="Magnified 3D purple image of a protein molecule on a blue background. " /> </div> </div></div></div></div><p class="group-featured-content-text field-group-html-element"><div class="field field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Discover how Bio-Techne prioritizes your success with cutting-edge techniques like SEC-MALS for protein characterization. </div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.bio-techne.com/reagents/proteins/sec-mals" target="_blank">See SEC-MALS Data</a></div></div></div></div></div></div> </div> </div> </div><div class="field-item even"><div class="entity entity-paragraphs-item paragraphs-item-featured-content" about="" typeof=""> <div class="content"> <div class="collapsible group-featured-content field-group-div m-featured-product speed-fast effect-none"> <h3><span class="field-group-format-toggler">Featured Content</span></h3> <div class="field-group-format-wrapper" style="display: block;"><h4 class="group-title-wrapper field-group-html-element"><div class="field field-name-field-featured-title field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.rndsystems.com/resources/articles/fluorokine-app-note">Application Note: Evaluating CAR Expression on CAR-T Cells Using Fluorokines™</a></div></div></div></h4><div class="required-fields group-img-wrapper field-group-html-element"><div class="field field-name-field-img field-type-et-image-field field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="https://resources.rndsystems.com/images/frontpage/new/fluorokine-app-note-featured-content.png" class="et-image-image" alt="Fluorokine App Note" /> </div> </div></div></div></div><p class="group-featured-content-text field-group-html-element"><div class="field field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Learn about the advantages of using fluorescent-labeled proteins to directly stain and detect CAR+ cells by flow cytometry.</div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.rndsystems.com/resources/articles/fluorokine-app-note">Read Fluorokines App Note</a></div></div></div></div></div></div> </div> </div> </div><div class="field-item odd"><div class="entity entity-paragraphs-item paragraphs-item-featured-content" about="" typeof=""> <div class="content"> <div class="collapsible group-featured-content field-group-div m-featured-product speed-fast effect-none"> <h3><span class="field-group-format-toggler">Featured Content</span></h3> <div class="field-group-format-wrapper" style="display: block;"><h4 class="group-title-wrapper field-group-html-element"><div class="field field-name-field-featured-title field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.bio-techne.com/resources/literature/organoids-model-systems-of-tissue-development-and-disease-poster" target="_blank">Organoids Wall Poster</a></div></div></div></h4><div class="required-fields group-img-wrapper field-group-html-element"><div class="field field-name-field-img field-type-et-image-field field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="//resources.rndsystems.com/images/research-areas/rnd-organoid-wall-poster-featured-content-v4.jpg" class="et-image-image" alt="Snapshot of the new organoids wall poster" /> </div> </div></div></div></div><p class="group-featured-content-text field-group-html-element"><div class="field field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Decorate your lab with some visually stunning organoid images generated by our 3-D cell culture specialists.</div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.bio-techne.com/resources/literature/organoids-model-systems-of-tissue-development-and-disease-poster" target="_blank">Request Organoids Poster</a></div></div></div></div></div></div> </div> </div> </div><div 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even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="https://resources.rndsystems.com/images/design/750x471-io-poster.jpg" class="et-image-image" alt="Immune Checkpoint Targets for Cancer Immunotherapy Research Poster" /> </div> </div></div></div></div><p class="group-featured-content-text field-group-html-element"><div class="field field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Use our new wall poster to explore the current and emerging immune checkpoint molecules being targeted for cancer immunotherapy </div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a 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on current and emerging immune checkpoint targets for cancer immunotherapy</div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.bio-techne.com/resources/literature/current-and-emerging-immune-checkpoint-targets-immuno-oncology-research-ebook" target="_blank">Request Immuno-Oncology ebook</a></div></div></div></div></div></div> </div> </div> </div><div class="field-item even"><div class="entity entity-paragraphs-item paragraphs-item-featured-content" about="" typeof=""> <div class="content"> <div class="collapsible group-featured-content field-group-div m-featured-product speed-fast effect-none"> <h3><span class="field-group-format-toggler">Featured Content</span></h3> <div class="field-group-format-wrapper" style="display: block;"><h4 class="group-title-wrapper 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field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Learn the importance of growth factor bioactivity and reagent consistency for achieving robust, reproducible organoid growth</div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.rndsystems.com/resources/articles/optimizing-organoid-culture-conditions-importance-growth-factor-bioactivity-and-reagent-consistency">Read Organoid Culture App Note</a></div></div></div></div></div></div> </div> </div> </div></div></div></div> </div></div> </article> </section> <section id="block-block-26" class="block block-block clearfix">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: 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