뇌연구원, 초소형 뇌 내시경 결합 브레인칩 플랫폼 개발

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은종희, 김정섭 박사후연구원.[한국뇌연구원 제공]</td></tr></table><br><br>[헤럴드경제=구본혁 기자] 한국뇌연구원은 정서인지 질환 연구그룹의 추남선 박사 연구팀이 소동물의 신경에서 실시간 신경 활성을 형광 신호로 측정하기 위한 초소형 뇌 형광 내시경 시스템에 전기적 신경신호 측정 기능을 결합한 다기능 브레인칩 플랫폼을 개발했다고 26일 밝혔다.<br><br>과학자들은 뇌 기능을 심도 있게 이해하기 위해 행동에 제약이 적으면서 신경세포의 종류별 신경 활성을 측정할 수 있는 초소형 형광 뇌 내시경 시스템(micro-endoscope)을 이용하고 있다. 이러한 시스템은 현미경과 같은 시야를 가지고 있으면서 살아있는 쥐에서 신경 활동의 실시간 기록이 가능하다. 하지만 신호의 반응이 느린 형광 신호를 이용하기 때문에 신경회로 활성의 실시간 분석이 제한적이다. 이 때문에 행동에 따른 신경 활동의 실시간 분석을 위해서는 전기적 신경신호의 측정이 필수적이다. 기존에 초소형 형광 내시경 시스템은 그 구조와 무게가 커 신경 활동을 측정하기 위한 신경전극과 집적에 제한이 있었다.<br><br>추남선 박사 연구팀은 신경세포의 활동을 다각적으로 높은 시공간적 해상도로 측정하기 위해 초소형 뇌 형광 내시경 시스템과 뇌 표면에서 전기신호를 측정하는 데 쓰는 투명하고 유연한 ECoG 전극 배열체를 초소형 모듈로 결합한 ‘ECoGScope(ECoG 전극 배열체와 micro-endoscope의 합성어)’ 플랫폼을 개발했다.<br><br>연구팀은 ‘ECoGScope’ 플랫폼이 초소형 및 초경량으로 설계돼 생쥐와 같은 소형 실험동물의 뇌신경에 부착해도 행동에 미치는 영향이 매우 낮고, 높은 정밀도로 신경신호를 측정할 수 있다고 설명했다.<br><br>연구팀이 ECoGScope 플랫폼을 생쥐의 뇌 시각피질(visual cortex) 및 감각 피질(sensory cortex)에 삽입하여 빛과 통증에 따라 나타나는 신경회로의 활성도를 정밀하게 측정할 수 있음을 확인했다.<br><br>또한 코카인에 중독된 동물모델에 이 시스템을 적용하여 중독 상태에서 신경회로의 변화를 전기 및 형광 신호로 동시에 기록하고 통합적으로 분석하여 중독 현상을 심도 있게 이해할 수 있게 되었다.<br><br>추남선 박사는 “이번에 개발한 ECoGScope 플랫폼은 중독, 우울증 등 다양한 정서·인지 질환 동물모델의 신경회로 분석 연구에 광범위하게 활용할 수 있다”면서 “뇌질환 기전 규명, 신경회로 기반 진단기법 개발 및 새로운 치료제 개발에 큰 도움이 될 것”이라고 말했다.<br><br>이번 연구결과는 국제학술지 ‘Biosensors and Bioelectronics’ 최신호에 게재됐다.<br><br> </article> </div> <div class="byline"> <p class="byline_p"> <span class="byline_s">구본혁 nbgkoo@heraldcorp.com</span> </p> </div> <div class="newsct_journalist"> <div class="newsct_journalist_inner"> <h4 class="blind">기자 프로필</h4> <div class="media_journalistcard _JOURNALIST_CARD _MORE_WRAP"> <div id="JOURNALIST_CARD_LIST" class="media_journalistcard_inner"> <div class="media_journalistcard_item _SUBSCRIBE_ELE" data-subscribe-type="JOURNALIST" data-current-subscribe="true"> <div class="media_journalistcard_item_inner"> <div class="media_journalistcard_intro"> <div class="media_journalistcard_summary"> <span 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</div> </div> </div> </script> <div id="_MODAL_TOAST" style="display: none;"></div> <script type="x-tmpl-mustache" class="_MODAL_TOAST_TEMPLATE"> <div class="nds_popover_toast as_center"> <div class="nds_toast_text_area"> <div class="nds_toast_text_area"><span class="nds_toast_ellipsis_text"><strong>{{toastTitle}}</strong></span> {{toastMessage}}</div> </div> </div> </script> <div id="_TICKER_LAYER_FOR_NOTIFICATION" class="ticker" style="display: none;"></div> <script type="x-tmpl-mustache" class="_TICKER_LAYER_TEMPLATE_FOR_NOTIFICATION"> {{#officeInfos}} <p class="t_inner"><em class="t_point">{{officeName}}</em> 언론사 알림이 설정되었습니다.</p> {{/officeInfos}} </script> <script src="https://static-nnews.pstatic.net/js/min/20250220/library.min.js" crossorigin="anonymous" onerror="neloSender.sendErrorToNelo('스크립트 로딩 에러 : ' + this.src);"></script> <script src="https://static-nnews.pstatic.net/js/min/20250220/read.min.js" crossorigin="anonymous" onerror="neloSender.sendErrorToNelo('스크립트 로딩 에러 : ' + this.src);"></script> <script> window.ntm = window.ntm || []; var ntmOption = {}; if (ntmOption) { var section = {"id":"105","name":"IT"}; var redirectSection = {"id":"105","name":"IT"}; ntmOption["channelId"] = article.officeId; // 기타 또는 주요 섹션 이름 var nilSendSectionName = "기타"; var nilSendSectionId = ""; if (/100|101|102|103|104|105|106|107/.test(section.id)) { nilSendSectionName = section.name; nilSendSectionId = section.id; } // 기사 타입 var htArticleTypeName = { "0": "text", "1": "photo", "2": "tv" }; var articleTypeName = htArticleTypeName[article.type] || ""; ntmOption["hitType"] = "cv"; ntmOption["eventCategory"] = "post_view"; ntmOption["uri"] = "http://news.naver.com/main/read.nhn?oid=016&aid=0002434642"; ntmOption["gdid"] = article.gdid; ntmOption["dimension1"] = encodeURIComponent(nilSendSectionName); ntmOption["dimension4"] = articleTypeName; ntmOption["optional2"] = nilSendSectionId; var journalistIdList = []; // 기자 목록 $("._JOURNALIST_CARD ._JOURNALIST_ID").each(function (index, object) { var $this = $(object); var journalistId = $this.attr("data-journalistId"); if (journalistId && journalistIdList.indexOf(journalistId) === -1) { journalistIdList.push(journalistId); } }); if (journalistIdList.length > 0) { ntmOption["dimension3"] = journalistIdList.join("___"); } if (location.href.match(/ntype=RANKING/)) { ntmOption["dimension5"] = "y"; } if (service.sports || service.newsType) { ntmOption["dimension2"] = article.sectionInfo.secondSection + "." + article.sectionInfo.thirdSection; } var seriesComponentId = $("._VALID_SERIES").attr("data-component-id"); ntmOption["dimension6"] = seriesComponentId; var issueComponentId = $("._ISSUE_ARTICLE_INFO").attr("data-component-id"); ntmOption["dimension8"] = issueComponentId; if (/[?|&]type=breakingnews(&|$)/.test(location.href) === true) { if (/(m\.naver\.com)|(media\.naver\.com)|(news\.naver\.com\/?$)|(www\.naver\.com)/.test(document.referrer) === true) { ntmOption["dimension7"] = "breaking"; } } var ntmLeaveOption = $.extend({}, ntmOption); ntmLeaveOption["hitType"] = "event"; ntmLeaveOption["eventCategory"] = "action"; ntmLeaveOption["eventAction"] = "leave"; if (/\/article\/comment\//.test(location.href) == false && $("#contents").length > 0) { if (window.addEventListener) { window.addEventListener("load", function () { ntm.push({ event: "nilSend", ni: ntmOption }); }, false); window.addEventListener("onpagehide" in window ? "pagehide" : "beforeunload", function () { ntm.push({ event: "nilSend", ni: ntmLeaveOption }); }, false); } else if (window.attachEvent) { window.attachEvent("onload", function () { ntm.push({ event: "nilSend", ni: ntmOption }); }); window.attachEvent("onpagehide" in window ? "onpagehide" : "onbeforeunload", function () { ntm.push({ event: "nilSend", ni: ntmLeaveOption }); }); } else { var onUnloadEventName = "onpagehide" in window ? "onpagehide" : "onbeforeunload"; var fnOnUnload = window[onUnloadEventName]; window[onUnloadEventName] = function () { ntm.push({ event: "nilSend", ni: ntmLeaveOption }); if (fnOnUnload) { fnOnUnload(); } }; var fnOnload = window.onload; window.onload = function () { ntm.push({ event: "nilSend", ni: ntmOption }); if (fnOnload) { fnOnload(); } }; } } } </script> </div> <script> var eventType = "onpageshow" in window ? "pageshow" : "load"; $(window).on(eventType, function() { window.ntm = window.ntm || []; var pageviewInfo = { event: "nLogPageViewService", nlogEvt: { page_layout: window.layoutName } }; pageviewInfo.nLogPageviewSti = "news"; pageviewInfo.nLogPageviewGdid = "8800010E_000000000000000002434642"; window.ntm.push(pageviewInfo); // ma 로그 전송 var data = { "service": "news", "baseInfo": { "category": (/\/article\/comment\//.test(location.href) == true) ? "댓글" : "본문" }, "extraInfo": { "articleId": article.articleId, "sectionId": article.sectionId, "officeId": article.officeId, "articleType": article.type } }; if (typeof ma !== "undefined") { ma.init({ api: "https://ma.news.naver.com/l", data: data, contentBodyEl: document.querySelector("._article_content"), contentBodyVideoWrapperSelector: "._VIDEO_AREA" }); } if (window.matchMedia("(prefers-color-scheme)").media === "not all") { $("html").removeClass("DARK_THEME"); } setTimeout(function() { $("._OPACITY_FADE_TO").fadeTo(50, 1); }, 3000); }); </script> </body> </html>

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