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HIV/AIDS - Wikipedia

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id="toc-Signs_and_symptoms-sublist" class="vector-toc-list"> <li id="toc-First_main_stage:_acute_infection" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#First_main_stage:_acute_infection"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>First main stage: acute infection</span> </div> </a> <ul id="toc-First_main_stage:_acute_infection-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Second_main_stage:_clinical_latency" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Second_main_stage:_clinical_latency"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Second main stage: clinical latency</span> </div> </a> <ul id="toc-Second_main_stage:_clinical_latency-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Third_main_stage:_AIDS" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Third_main_stage:_AIDS"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>Third main stage: AIDS</span> </div> </a> <ul id="toc-Third_main_stage:_AIDS-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Transmission" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Transmission"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Transmission</span> </div> </a> <button aria-controls="toc-Transmission-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Transmission subsection</span> </button> <ul id="toc-Transmission-sublist" class="vector-toc-list"> <li id="toc-Sexual" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Sexual"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Sexual</span> </div> </a> <ul id="toc-Sexual-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Body_fluids" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Body_fluids"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Body fluids</span> </div> </a> <ul id="toc-Body_fluids-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mother-to-child" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mother-to-child"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>Mother-to-child</span> </div> </a> <ul id="toc-Mother-to-child-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Virology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Virology"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Virology</span> </div> </a> <ul id="toc-Virology-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pathophysiology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Pathophysiology"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Pathophysiology</span> </div> </a> <ul id="toc-Pathophysiology-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Diagnosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Diagnosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Diagnosis</span> </div> </a> <button aria-controls="toc-Diagnosis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Diagnosis subsection</span> </button> <ul id="toc-Diagnosis-sublist" class="vector-toc-list"> <li id="toc-HIV_testing" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#HIV_testing"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>HIV testing</span> </div> </a> <ul id="toc-HIV_testing-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Classifications" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Classifications"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Classifications</span> </div> </a> <ul id="toc-Classifications-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Prevention" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Prevention"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Prevention</span> </div> </a> <button aria-controls="toc-Prevention-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Prevention subsection</span> </button> <ul id="toc-Prevention-sublist" class="vector-toc-list"> <li id="toc-Sexual_contact" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Sexual_contact"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Sexual contact</span> </div> </a> <ul id="toc-Sexual_contact-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pre-exposure" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pre-exposure"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Pre-exposure</span> </div> </a> <ul id="toc-Pre-exposure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Post-exposure" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Post-exposure"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>Post-exposure</span> </div> </a> <ul id="toc-Post-exposure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mother-to-child_2" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mother-to-child_2"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.4</span> <span>Mother-to-child</span> </div> </a> <ul id="toc-Mother-to-child_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vaccination" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Vaccination"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.5</span> <span>Vaccination</span> </div> </a> <ul id="toc-Vaccination-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Treatment" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Treatment"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Treatment</span> </div> </a> <button aria-controls="toc-Treatment-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Treatment subsection</span> </button> <ul id="toc-Treatment-sublist" class="vector-toc-list"> <li id="toc-Antiviral_therapy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Antiviral_therapy"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Antiviral therapy</span> </div> </a> <ul id="toc-Antiviral_therapy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Opportunistic_infections" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Opportunistic_infections"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2</span> <span>Opportunistic infections</span> </div> </a> <ul id="toc-Opportunistic_infections-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Diet" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Diet"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.3</span> <span>Diet</span> </div> </a> <ul id="toc-Diet-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Alternative_medicine" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Alternative_medicine"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.4</span> <span>Alternative medicine</span> </div> </a> <ul id="toc-Alternative_medicine-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Prognosis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Prognosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Prognosis</span> </div> </a> <ul id="toc-Prognosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Epidemiology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Epidemiology"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Epidemiology</span> </div> </a> <ul id="toc-Epidemiology-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>History</span> </div> </a> <button aria-controls="toc-History-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle History subsection</span> </button> <ul id="toc-History-sublist" class="vector-toc-list"> <li id="toc-Discovery" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Discovery"> <div class="vector-toc-text"> <span class="vector-toc-numb">10.1</span> <span>Discovery</span> </div> </a> <ul id="toc-Discovery-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Origins" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Origins"> <div class="vector-toc-text"> <span class="vector-toc-numb">10.2</span> <span>Origins</span> </div> </a> <ul id="toc-Origins-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>Society and culture</span> </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Society and culture subsection</span> </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Stigma" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Stigma"> <div class="vector-toc-text"> <span class="vector-toc-numb">11.1</span> <span>Stigma</span> </div> </a> <ul id="toc-Stigma-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Economic_impact" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Economic_impact"> <div class="vector-toc-text"> <span class="vector-toc-numb">11.2</span> <span>Economic impact</span> </div> </a> <ul id="toc-Economic_impact-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Religion_and_AIDS" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Religion_and_AIDS"> <div class="vector-toc-text"> <span class="vector-toc-numb">11.3</span> <span>Religion and AIDS</span> </div> </a> <ul id="toc-Religion_and_AIDS-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Media_portrayal" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Media_portrayal"> <div class="vector-toc-text"> <span class="vector-toc-numb">11.4</span> <span>Media portrayal</span> </div> </a> <ul id="toc-Media_portrayal-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Criminal_transmission" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Criminal_transmission"> <div class="vector-toc-text"> <span class="vector-toc-numb">11.5</span> <span>Criminal transmission</span> </div> </a> <ul id="toc-Criminal_transmission-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Misconceptions" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Misconceptions"> <div class="vector-toc-text"> <span class="vector-toc-numb">11.6</span> <span>Misconceptions</span> </div> </a> <ul id="toc-Misconceptions-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Research" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Research"> <div class="vector-toc-text"> <span class="vector-toc-numb">12</span> <span>Research</span> </div> </a> <ul id="toc-Research-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">13</span> <span>References</span> </div> </a> <button aria-controls="toc-References-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle References subsection</span> </button> <ul id="toc-References-sublist" class="vector-toc-list"> <li id="toc-Notes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Notes"> <div class="vector-toc-text"> <span class="vector-toc-numb">13.1</span> <span>Notes</span> </div> </a> <ul id="toc-Notes-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">14</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">HIV/AIDS</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 180 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-180" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">180 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Vigs" title="Vigs – Afrikaans" lang="af" hreflang="af" data-title="Vigs" data-language-autonym="Afrikaans" data-language-local-name="Afrikaans" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-als mw-list-item"><a href="https://als.wikipedia.org/wiki/AIDS" title="AIDS – Alemannic" lang="gsw" hreflang="gsw" data-title="AIDS" data-language-autonym="Alemannisch" data-language-local-name="Alemannic" class="interlanguage-link-target"><span>Alemannisch</span></a></li><li class="interlanguage-link interwiki-am mw-list-item"><a href="https://am.wikipedia.org/wiki/%E1%8A%A4%E1%8B%B5%E1%88%B5" title="ኤድስ – Amharic" lang="am" hreflang="am" data-title="ኤድስ" data-language-autonym="አማርኛ" data-language-local-name="Amharic" class="interlanguage-link-target"><span>አማርኛ</span></a></li><li class="interlanguage-link interwiki-anp mw-list-item"><a href="https://anp.wikipedia.org/wiki/%E0%A4%8F%E0%A4%A1%E0%A5%8D%E0%A4%B8" title="एड्स – Angika" lang="anp" hreflang="anp" data-title="एड्स" data-language-autonym="अंगिका" data-language-local-name="Angika" class="interlanguage-link-target"><span>अंगिका</span></a></li><li class="interlanguage-link interwiki-ar badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D9%8A%D8%AF%D8%B2" title="إيدز – Arabic" lang="ar" hreflang="ar" data-title="إيدز" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-an mw-list-item"><a href="https://an.wikipedia.org/wiki/SIDA" title="SIDA – Aragonese" lang="an" hreflang="an" data-title="SIDA" data-language-autonym="Aragonés" data-language-local-name="Aragonese" class="interlanguage-link-target"><span>Aragonés</span></a></li><li class="interlanguage-link interwiki-as mw-list-item"><a href="https://as.wikipedia.org/wiki/%E0%A6%8F%E0%A6%87%E0%A6%9A.%E0%A6%86%E0%A6%87.%E0%A6%AD%E0%A6%BF/%E0%A6%8F%E0%A6%87%E0%A6%A1%E0%A7%8D%E2%80%8C%E0%A6%9B" title="এইচ.আই.ভি/এইড্‌ছ – Assamese" lang="as" hreflang="as" data-title="এইচ.আই.ভি/এইড্‌ছ" data-language-autonym="অসমীয়া" data-language-local-name="Assamese" class="interlanguage-link-target"><span>অসমীয়া</span></a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Sida" title="Sida – Asturian" lang="ast" hreflang="ast" data-title="Sida" data-language-autonym="Asturianu" data-language-local-name="Asturian" class="interlanguage-link-target"><span>Asturianu</span></a></li><li class="interlanguage-link interwiki-gn mw-list-item"><a href="https://gn.wikipedia.org/wiki/VIH/sida" title="VIH/sida – Guarani" lang="gn" hreflang="gn" data-title="VIH/sida" data-language-autonym="Avañe&#039;ẽ" data-language-local-name="Guarani" class="interlanguage-link-target"><span>Avañe'ẽ</span></a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Q%C4%B0%C3%87S" title="QİÇS – Azerbaijani" lang="az" hreflang="az" data-title="QİÇS" data-language-autonym="Azərbaycanca" data-language-local-name="Azerbaijani" class="interlanguage-link-target"><span>Azərbaycanca</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%A7%D8%A6%DB%8C%D8%AF%D8%B2" title="ائیدز – South Azerbaijani" lang="azb" hreflang="azb" data-title="ائیدز" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bm mw-list-item"><a href="https://bm.wikipedia.org/wiki/Tangalan_d%C9%9Bs%C9%9B_Bana" title="Tangalan dɛsɛ Bana – Bambara" lang="bm" hreflang="bm" data-title="Tangalan dɛsɛ Bana" data-language-autonym="Bamanankan" data-language-local-name="Bambara" class="interlanguage-link-target"><span>Bamanankan</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%8F%E0%A6%87%E0%A6%9A%E0%A6%86%E0%A6%87%E0%A6%AD%E0%A6%BF/%E0%A6%8F%E0%A6%87%E0%A6%A1%E0%A6%B8" title="এইচআইভি/এইডস – Bangla" lang="bn" hreflang="bn" data-title="এইচআইভি/এইডস" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-zh-min-nan mw-list-item"><a href="https://zh-min-nan.wikipedia.org/wiki/AIDS" title="AIDS – Minnan" lang="nan" hreflang="nan" data-title="AIDS" data-language-autonym="閩南語 / Bân-lâm-gú" data-language-local-name="Minnan" class="interlanguage-link-target"><span>閩南語 / Bân-lâm-gú</span></a></li><li class="interlanguage-link interwiki-ba mw-list-item"><a href="https://ba.wikipedia.org/wiki/%D0%92%D0%98%D0%A7-%D0%B8%D0%BD%D1%84%D0%B5%D0%BA%D1%86%D0%B8%D1%8F" title="ВИЧ-инфекция – Bashkir" lang="ba" hreflang="ba" data-title="ВИЧ-инфекция" data-language-autonym="Башҡортса" data-language-local-name="Bashkir" class="interlanguage-link-target"><span>Башҡортса</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%A1%D0%9D%D0%86%D0%94" title="СНІД – Belarusian" lang="be" hreflang="be" data-title="СНІД" data-language-autonym="Беларуская" data-language-local-name="Belarusian" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-be-x-old mw-list-item"><a href="https://be-tarask.wikipedia.org/wiki/%D0%A1%D0%9D%D0%86%D0%94" title="СНІД – Belarusian (Taraškievica orthography)" lang="be-tarask" hreflang="be-tarask" data-title="СНІД" data-language-autonym="Беларуская (тарашкевіца)" data-language-local-name="Belarusian (Taraškievica orthography)" class="interlanguage-link-target"><span>Беларуская (тарашкевіца)</span></a></li><li class="interlanguage-link interwiki-bcl mw-list-item"><a href="https://bcl.wikipedia.org/wiki/AIDS" title="AIDS – Central Bikol" lang="bcl" hreflang="bcl" data-title="AIDS" data-language-autonym="Bikol Central" data-language-local-name="Central Bikol" class="interlanguage-link-target"><span>Bikol Central</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A1%D0%B8%D0%BD%D0%B4%D1%80%D0%BE%D0%BC_%D0%BD%D0%B0_%D0%BF%D1%80%D0%B8%D0%B4%D0%BE%D0%B1%D0%B8%D1%82%D0%B0%D1%82%D0%B0_%D0%B8%D0%BC%D1%83%D0%BD%D0%BD%D0%B0_%D0%BD%D0%B5%D0%B4%D0%BE%D1%81%D1%82%D0%B0%D1%82%D1%8A%D1%87%D0%BD%D0%BE%D1%81%D1%82" title="Синдром на придобитата имунна недостатъчност – Bulgarian" lang="bg" hreflang="bg" data-title="Синдром на придобитата имунна недостатъчност" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bo mw-list-item"><a href="https://bo.wikipedia.org/wiki/%E0%BD%A8%E0%BD%BA%E0%BC%8B%E0%BD%9B%E0%BD%B2%E0%BD%A0%E0%BD%B2%E0%BC%8B%E0%BD%93%E0%BD%91%E0%BC%8B" title="ཨེ་ཛིའི་ནད་ – Tibetan" lang="bo" hreflang="bo" data-title="ཨེ་ཛིའི་ནད་" data-language-autonym="བོད་ཡིག" data-language-local-name="Tibetan" class="interlanguage-link-target"><span>བོད་ཡིག</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Sindrom_ste%C4%8Dene_imunodeficijencije" title="Sindrom stečene imunodeficijencije – Bosnian" lang="bs" hreflang="bs" data-title="Sindrom stečene imunodeficijencije" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-br mw-list-item"><a href="https://br.wikipedia.org/wiki/SIDA" title="SIDA – Breton" lang="br" hreflang="br" data-title="SIDA" data-language-autonym="Brezhoneg" data-language-local-name="Breton" class="interlanguage-link-target"><span>Brezhoneg</span></a></li><li class="interlanguage-link interwiki-bxr mw-list-item"><a href="https://bxr.wikipedia.org/wiki/%D0%94%D0%B0%D1%80%D1%85%D0%B0%D0%BB%D0%B0%D0%BB%D0%B0%D0%B9_%D0%BE%D0%BB%D0%B4%D0%BE%D0%BC%D0%BE%D0%BB_%D1%85%D0%BE%D0%BC%D1%81%D0%BE%D0%B4%D0%BE%D0%BB" title="Дархалалай олдомол хомсодол – Russia Buriat" lang="bxr" hreflang="bxr" data-title="Дархалалай олдомол хомсодол" data-language-autonym="Буряад" data-language-local-name="Russia Buriat" class="interlanguage-link-target"><span>Буряад</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Infecci%C3%B3_pel_VIH_i_sida" title="Infecció pel VIH i sida – Catalan" lang="ca" hreflang="ca" data-title="Infecció pel VIH i sida" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cv mw-list-item"><a href="https://cv.wikipedia.org/wiki/%D0%95%D0%98%D0%94%D0%9F" title="ЕИДП – Chuvash" lang="cv" hreflang="cv" data-title="ЕИДП" data-language-autonym="Чӑвашла" data-language-local-name="Chuvash" class="interlanguage-link-target"><span>Чӑвашла</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/AIDS" title="AIDS – Czech" lang="cs" hreflang="cs" data-title="AIDS" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-sn mw-list-item"><a href="https://sn.wikipedia.org/wiki/Mukondombera_weAIDS" title="Mukondombera weAIDS – Shona" lang="sn" hreflang="sn" data-title="Mukondombera weAIDS" data-language-autonym="ChiShona" data-language-local-name="Shona" class="interlanguage-link-target"><span>ChiShona</span></a></li><li class="interlanguage-link interwiki-tum mw-list-item"><a href="https://tum.wikipedia.org/wiki/Edesi_(AIDS)" title="Edesi (AIDS) – Tumbuka" lang="tum" hreflang="tum" data-title="Edesi (AIDS)" data-language-autonym="ChiTumbuka" data-language-local-name="Tumbuka" class="interlanguage-link-target"><span>ChiTumbuka</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/AIDS" title="AIDS – Welsh" lang="cy" hreflang="cy" data-title="AIDS" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/AIDS" title="AIDS – Danish" lang="da" hreflang="da" data-title="AIDS" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-ary mw-list-item"><a href="https://ary.wikipedia.org/wiki/%D8%B3%D9%8A%D8%AF%D8%A7" title="سيدا – Moroccan Arabic" lang="ary" hreflang="ary" data-title="سيدا" data-language-autonym="الدارجة" data-language-local-name="Moroccan Arabic" class="interlanguage-link-target"><span>الدارجة</span></a></li><li class="interlanguage-link interwiki-de badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://de.wikipedia.org/wiki/AIDS" title="AIDS – German" lang="de" hreflang="de" data-title="AIDS" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-dv badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://dv.wikipedia.org/wiki/%DE%87%DE%AC%DE%87%DE%A8%DE%91%DE%B0%DE%90%DE%B0_%DE%84%DE%A6%DE%8D%DE%A8" title="އެއިޑްސް ބަލި – Divehi" lang="dv" hreflang="dv" data-title="އެއިޑްސް ބަލި" data-language-autonym="ދިވެހިބަސް" data-language-local-name="Divehi" class="interlanguage-link-target"><span>ދިވެހިބަސް</span></a></li><li class="interlanguage-link interwiki-nv mw-list-item"><a href="https://nv.wikipedia.org/wiki/Naa%C5%82niih_yich%CA%BC%C4%85%CC%81%C4%85%CC%81h_naabaah%C3%ADg%C3%AD%C3%AD_b%C4%85%C4%85h_dahoo%CA%BCaahgo" title="Naałniih yichʼą́ą́h naabaahígíí bąąh dahooʼaahgo – Navajo" lang="nv" hreflang="nv" data-title="Naałniih yichʼą́ą́h naabaahígíí bąąh dahooʼaahgo" data-language-autonym="Diné bizaad" data-language-local-name="Navajo" class="interlanguage-link-target"><span>Diné bizaad</span></a></li><li class="interlanguage-link interwiki-dty mw-list-item"><a href="https://dty.wikipedia.org/wiki/%E0%A4%8F%E0%A4%A1%E0%A5%8D%E0%A4%B8" title="एड्स – Doteli" lang="dty" hreflang="dty" data-title="एड्स" data-language-autonym="डोटेली" data-language-local-name="Doteli" class="interlanguage-link-target"><span>डोटेली</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/AIDS" title="AIDS – Estonian" lang="et" hreflang="et" data-title="AIDS" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-el badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://el.wikipedia.org/wiki/AIDS" title="AIDS – Greek" lang="el" hreflang="el" data-title="AIDS" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/VIH/sida" title="VIH/sida – Spanish" lang="es" hreflang="es" data-title="VIH/sida" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Aidoso" title="Aidoso – Esperanto" lang="eo" hreflang="eo" data-title="Aidoso" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-ext mw-list-item"><a href="https://ext.wikipedia.org/wiki/SIDA" title="SIDA – Extremaduran" lang="ext" hreflang="ext" data-title="SIDA" data-language-autonym="Estremeñu" data-language-local-name="Extremaduran" class="interlanguage-link-target"><span>Estremeñu</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Hartutako_Immunoeskasiaren_Sindromea" title="Hartutako Immunoeskasiaren Sindromea – Basque" lang="eu" hreflang="eu" data-title="Hartutako Immunoeskasiaren Sindromea" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D8%AF%D8%B2" title="ایدز – Persian" lang="fa" hreflang="fa" data-title="ایدز" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-hif mw-list-item"><a href="https://hif.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Fiji Hindi" lang="hif" hreflang="hif" data-title="HIV/AIDS" data-language-autonym="Fiji Hindi" data-language-local-name="Fiji Hindi" class="interlanguage-link-target"><span>Fiji Hindi</span></a></li><li class="interlanguage-link interwiki-fo mw-list-item"><a href="https://fo.wikipedia.org/wiki/Ey%C3%B0kv%C3%A6mi" title="Eyðkvæmi – Faroese" lang="fo" hreflang="fo" data-title="Eyðkvæmi" data-language-autonym="Føroyskt" data-language-local-name="Faroese" class="interlanguage-link-target"><span>Føroyskt</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Syndrome_d%27immunod%C3%A9ficience_acquise" title="Syndrome d&#039;immunodéficience acquise – French" lang="fr" hreflang="fr" data-title="Syndrome d&#039;immunodéficience acquise" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-fy mw-list-item"><a href="https://fy.wikipedia.org/wiki/AIDS" title="AIDS – Western Frisian" lang="fy" hreflang="fy" data-title="AIDS" data-language-autonym="Frysk" data-language-local-name="Western Frisian" class="interlanguage-link-target"><span>Frysk</span></a></li><li class="interlanguage-link interwiki-fur mw-list-item"><a href="https://fur.wikipedia.org/wiki/AIDS" title="AIDS – Friulian" lang="fur" hreflang="fur" data-title="AIDS" data-language-autonym="Furlan" data-language-local-name="Friulian" class="interlanguage-link-target"><span>Furlan</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/SEIF" title="SEIF – Irish" lang="ga" hreflang="ga" data-title="SEIF" data-language-autonym="Gaeilge" data-language-local-name="Irish" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-gd mw-list-item"><a href="https://gd.wikipedia.org/wiki/AIDS" title="AIDS – Scottish Gaelic" lang="gd" hreflang="gd" data-title="AIDS" data-language-autonym="Gàidhlig" data-language-local-name="Scottish Gaelic" class="interlanguage-link-target"><span>Gàidhlig</span></a></li><li class="interlanguage-link interwiki-gl badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://gl.wikipedia.org/wiki/Sida" title="Sida – Galician" lang="gl" hreflang="gl" data-title="Sida" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-gan mw-list-item"><a href="https://gan.wikipedia.org/wiki/%E8%89%BE%E6%BB%8B%E7%97%85" title="艾滋病 – Gan" lang="gan" hreflang="gan" data-title="艾滋病" data-language-autonym="贛語" data-language-local-name="Gan" class="interlanguage-link-target"><span>贛語</span></a></li><li class="interlanguage-link interwiki-ki mw-list-item"><a href="https://ki.wikipedia.org/wiki/AIDS" title="AIDS – Kikuyu" lang="ki" hreflang="ki" data-title="AIDS" data-language-autonym="Gĩkũyũ" data-language-local-name="Kikuyu" class="interlanguage-link-target"><span>Gĩkũyũ</span></a></li><li class="interlanguage-link interwiki-gu mw-list-item"><a href="https://gu.wikipedia.org/wiki/%E0%AA%8F%E0%AA%87%E0%AA%A1%E0%AB%8D%E0%AA%B8" title="એઇડ્સ – Gujarati" lang="gu" hreflang="gu" data-title="એઇડ્સ" data-language-autonym="ગુજરાતી" data-language-local-name="Gujarati" class="interlanguage-link-target"><span>ગુજરાતી</span></a></li><li class="interlanguage-link interwiki-gom mw-list-item"><a href="https://gom.wikipedia.org/wiki/%E0%A4%8F%E0%A4%A1%E0%A5%8D%E0%A4%B8" title="एड्स – Goan Konkani" lang="gom" hreflang="gom" data-title="एड्स" data-language-autonym="गोंयची कोंकणी / Gõychi Konknni" data-language-local-name="Goan Konkani" class="interlanguage-link-target"><span>गोंयची कोंकणी / Gõychi Konknni</span></a></li><li class="interlanguage-link interwiki-hak mw-list-item"><a href="https://hak.wikipedia.org/wiki/AIDS" title="AIDS – Hakka Chinese" lang="hak" hreflang="hak" data-title="AIDS" data-language-autonym="客家語 / Hak-kâ-ngî" data-language-local-name="Hakka Chinese" class="interlanguage-link-target"><span>客家語 / Hak-kâ-ngî</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%9B%84%EC%B2%9C%EB%A9%B4%EC%97%AD%EA%B2%B0%ED%95%8D%EC%A6%9D%ED%9B%84%EA%B5%B0" title="후천면역결핍증후군 – Korean" lang="ko" hreflang="ko" data-title="후천면역결핍증후군" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ha mw-list-item"><a href="https://ha.wikipedia.org/wiki/Kanjamau" title="Kanjamau – Hausa" lang="ha" hreflang="ha" data-title="Kanjamau" data-language-autonym="Hausa" data-language-local-name="Hausa" class="interlanguage-link-target"><span>Hausa</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%84%D4%BB%D4%B1%D5%8E/%D5%81%D4%BB%D4%B1%D5%80" title="ՄԻԱՎ/ՁԻԱՀ – Armenian" lang="hy" hreflang="hy" data-title="ՄԻԱՎ/ՁԻԱՀ" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%8F%E0%A4%A1%E0%A5%8D%E0%A4%B8" title="एड्स – Hindi" lang="hi" hreflang="hi" data-title="एड्स" data-language-autonym="हिन्दी" data-language-local-name="Hindi" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Sindrom_ste%C4%8Dene_imunodeficijencije" title="Sindrom stečene imunodeficijencije – Croatian" lang="hr" hreflang="hr" data-title="Sindrom stečene imunodeficijencije" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-gor mw-list-item"><a href="https://gor.wikipedia.org/wiki/AIDS" title="AIDS – Gorontalo" lang="gor" hreflang="gor" data-title="AIDS" data-language-autonym="Bahasa Hulontalo" data-language-local-name="Gorontalo" class="interlanguage-link-target"><span>Bahasa Hulontalo</span></a></li><li class="interlanguage-link interwiki-io mw-list-item"><a href="https://io.wikipedia.org/wiki/Sindromo_di_Imuno-Defekteso_Aquirita" title="Sindromo di Imuno-Defekteso Aquirita – Ido" lang="io" hreflang="io" data-title="Sindromo di Imuno-Defekteso Aquirita" data-language-autonym="Ido" data-language-local-name="Ido" class="interlanguage-link-target"><span>Ido</span></a></li><li class="interlanguage-link interwiki-ig mw-list-item"><a href="https://ig.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Igbo" lang="ig" hreflang="ig" data-title="HIV/AIDS" data-language-autonym="Igbo" data-language-local-name="Igbo" class="interlanguage-link-target"><span>Igbo</span></a></li><li class="interlanguage-link interwiki-ilo mw-list-item"><a href="https://ilo.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Iloko" lang="ilo" hreflang="ilo" data-title="HIV/AIDS" data-language-autonym="Ilokano" data-language-local-name="Iloko" class="interlanguage-link-target"><span>Ilokano</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/AIDS" title="AIDS – Indonesian" lang="id" hreflang="id" data-title="AIDS" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ia badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://ia.wikipedia.org/wiki/SIDA" title="SIDA – Interlingua" lang="ia" hreflang="ia" data-title="SIDA" data-language-autonym="Interlingua" data-language-local-name="Interlingua" class="interlanguage-link-target"><span>Interlingua</span></a></li><li class="interlanguage-link interwiki-is mw-list-item"><a href="https://is.wikipedia.org/wiki/Aln%C3%A6mi" title="Alnæmi – Icelandic" lang="is" hreflang="is" data-title="Alnæmi" data-language-autonym="Íslenska" data-language-local-name="Icelandic" class="interlanguage-link-target"><span>Íslenska</span></a></li><li class="interlanguage-link interwiki-it badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://it.wikipedia.org/wiki/AIDS" title="AIDS – Italian" lang="it" hreflang="it" data-title="AIDS" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%99%D7%99%D7%93%D7%A1" title="איידס – Hebrew" lang="he" hreflang="he" data-title="איידס" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-jv mw-list-item"><a href="https://jv.wikipedia.org/wiki/AIDS" title="AIDS – Javanese" lang="jv" hreflang="jv" data-title="AIDS" data-language-autonym="Jawa" data-language-local-name="Javanese" class="interlanguage-link-target"><span>Jawa</span></a></li><li class="interlanguage-link interwiki-kbp mw-list-item"><a href="https://kbp.wikipedia.org/wiki/Sidaa" title="Sidaa – Kabiye" lang="kbp" hreflang="kbp" data-title="Sidaa" data-language-autonym="Kabɩyɛ" data-language-local-name="Kabiye" class="interlanguage-link-target"><span>Kabɩyɛ</span></a></li><li class="interlanguage-link interwiki-kn mw-list-item"><a href="https://kn.wikipedia.org/wiki/%E0%B2%8F%E0%B2%A1%E0%B3%8D%E0%B2%B8%E0%B3%8D_%E0%B2%B0%E0%B3%8B%E0%B2%97" title="ಏಡ್ಸ್ ರೋಗ – Kannada" lang="kn" hreflang="kn" data-title="ಏಡ್ಸ್ ರೋಗ" data-language-autonym="ಕನ್ನಡ" data-language-local-name="Kannada" class="interlanguage-link-target"><span>ಕನ್ನಡ</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%A8%E1%83%98%E1%83%93%E1%83%A1%E1%83%98" title="შიდსი – Georgian" lang="ka" hreflang="ka" data-title="შიდსი" data-language-autonym="ქართული" data-language-local-name="Georgian" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-ks mw-list-item"><a href="https://ks.wikipedia.org/wiki/%D8%A7%DB%8C%DA%88%D9%95%D8%B3" title="ایڈٕس – Kashmiri" lang="ks" hreflang="ks" data-title="ایڈٕس" data-language-autonym="कॉशुर / کٲشُر" data-language-local-name="Kashmiri" class="interlanguage-link-target"><span>कॉशुर / کٲشُر</span></a></li><li class="interlanguage-link interwiki-kk badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://kk.wikipedia.org/wiki/%D0%90%D0%98%D0%92/%D0%96%D0%98%D0%A2%D0%A1" title="АИВ/ЖИТС – Kazakh" lang="kk" hreflang="kk" data-title="АИВ/ЖИТС" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-sw mw-list-item"><a href="https://sw.wikipedia.org/wiki/Ukimwi" title="Ukimwi – Swahili" lang="sw" hreflang="sw" data-title="Ukimwi" data-language-autonym="Kiswahili" data-language-local-name="Swahili" class="interlanguage-link-target"><span>Kiswahili</span></a></li><li class="interlanguage-link interwiki-kg mw-list-item"><a href="https://kg.wikipedia.org/wiki/Sida" title="Sida – Kongo" lang="kg" hreflang="kg" data-title="Sida" data-language-autonym="Kongo" data-language-local-name="Kongo" class="interlanguage-link-target"><span>Kongo</span></a></li><li class="interlanguage-link interwiki-ht mw-list-item"><a href="https://ht.wikipedia.org/wiki/Sida" title="Sida – Haitian Creole" lang="ht" hreflang="ht" data-title="Sida" data-language-autonym="Kreyòl ayisyen" data-language-local-name="Haitian Creole" class="interlanguage-link-target"><span>Kreyòl ayisyen</span></a></li><li class="interlanguage-link interwiki-gcr mw-list-item"><a href="https://gcr.wikipedia.org/wiki/Sendromm_di_iminod%C3%A9fisyans_akiz" title="Sendromm di iminodéfisyans akiz – Guianan Creole" lang="gcr" hreflang="gcr" data-title="Sendromm di iminodéfisyans akiz" data-language-autonym="Kriyòl gwiyannen" data-language-local-name="Guianan Creole" class="interlanguage-link-target"><span>Kriyòl gwiyannen</span></a></li><li class="interlanguage-link interwiki-ku mw-list-item"><a href="https://ku.wikipedia.org/wiki/AIDS" title="AIDS – Kurdish" lang="ku" hreflang="ku" data-title="AIDS" data-language-autonym="Kurdî" data-language-local-name="Kurdish" class="interlanguage-link-target"><span>Kurdî</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%A1%D0%9F%D0%98%D0%94" title="СПИД – Kyrgyz" lang="ky" hreflang="ky" data-title="СПИД" data-language-autonym="Кыргызча" data-language-local-name="Kyrgyz" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-lo mw-list-item"><a href="https://lo.wikipedia.org/wiki/%E0%BB%80%E0%BA%AD%E0%BA%94%E0%BA%AA%E0%BB%8C" title="ເອດສ໌ – Lao" lang="lo" hreflang="lo" data-title="ເອດສ໌" data-language-autonym="ລາວ" data-language-local-name="Lao" class="interlanguage-link-target"><span>ລາວ</span></a></li><li class="interlanguage-link interwiki-la badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://la.wikipedia.org/wiki/Morbus_deficientiae_immunitatis_acquisitae" title="Morbus deficientiae immunitatis acquisitae – Latin" lang="la" hreflang="la" data-title="Morbus deficientiae immunitatis acquisitae" data-language-autonym="Latina" data-language-local-name="Latin" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/AIDS" title="AIDS – Latvian" lang="lv" hreflang="lv" data-title="AIDS" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-lb mw-list-item"><a href="https://lb.wikipedia.org/wiki/Aids" title="Aids – Luxembourgish" lang="lb" hreflang="lb" data-title="Aids" data-language-autonym="Lëtzebuergesch" data-language-local-name="Luxembourgish" class="interlanguage-link-target"><span>Lëtzebuergesch</span></a></li><li class="interlanguage-link interwiki-lez mw-list-item"><a href="https://lez.wikipedia.org/wiki/%D0%9A%D1%8A%D0%98%D0%94%D0%A1" title="КъИДС – Lezghian" lang="lez" hreflang="lez" data-title="КъИДС" data-language-autonym="Лезги" data-language-local-name="Lezghian" class="interlanguage-link-target"><span>Лезги</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/AIDS" title="AIDS – Lithuanian" lang="lt" hreflang="lt" data-title="AIDS" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-li mw-list-item"><a href="https://li.wikipedia.org/wiki/AIDS" title="AIDS – Limburgish" lang="li" hreflang="li" data-title="AIDS" data-language-autonym="Limburgs" data-language-local-name="Limburgish" class="interlanguage-link-target"><span>Limburgs</span></a></li><li class="interlanguage-link interwiki-ln mw-list-item"><a href="https://ln.wikipedia.org/wiki/Sid%C3%A1" title="Sidá – Lingala" lang="ln" hreflang="ln" data-title="Sidá" data-language-autonym="Lingála" data-language-local-name="Lingala" class="interlanguage-link-target"><span>Lingála</span></a></li><li class="interlanguage-link interwiki-lmo mw-list-item"><a href="https://lmo.wikipedia.org/wiki/AIDS" title="AIDS – Lombard" lang="lmo" hreflang="lmo" data-title="AIDS" data-language-autonym="Lombard" data-language-local-name="Lombard" class="interlanguage-link-target"><span>Lombard</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/AIDS" title="AIDS – Hungarian" lang="hu" hreflang="hu" data-title="AIDS" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-mad mw-list-item"><a href="https://mad.wikipedia.org/wiki/AIDS" title="AIDS – Madurese" lang="mad" hreflang="mad" data-title="AIDS" data-language-autonym="Madhurâ" data-language-local-name="Madurese" class="interlanguage-link-target"><span>Madhurâ</span></a></li><li class="interlanguage-link interwiki-mai mw-list-item"><a href="https://mai.wikipedia.org/wiki/%E0%A4%8F%E0%A4%A1%E0%A5%8D%E0%A4%B8" title="एड्स – Maithili" lang="mai" hreflang="mai" data-title="एड्स" data-language-autonym="मैथिली" data-language-local-name="Maithili" class="interlanguage-link-target"><span>मैथिली</span></a></li><li class="interlanguage-link interwiki-mk badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://mk.wikipedia.org/wiki/%D0%A1%D0%B8%D0%BD%D0%B4%D1%80%D0%BE%D0%BC_%D0%BD%D0%B0_%D1%81%D1%82%D0%B5%D0%BA%D0%BD%D0%B0%D1%82_%D0%B8%D0%BC%D1%83%D0%BD%D0%BE%D0%BB%D0%BE%D1%88%D0%BA%D0%B8_%D0%B4%D0%B5%D1%84%D0%B8%D1%86%D0%B8%D1%82" title="Синдром на стекнат имунолошки дефицит – Macedonian" lang="mk" hreflang="mk" data-title="Синдром на стекнат имунолошки дефицит" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%8E%E0%B4%AF%E0%B5%8D%E2%80%8C%E0%B4%A1%E0%B5%8D%E2%80%8C%E0%B4%B8%E0%B5%8D%E2%80%8C" title="എയ്‌ഡ്‌സ്‌ – Malayalam" lang="ml" hreflang="ml" data-title="എയ്‌ഡ്‌സ്‌" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-mt mw-list-item"><a href="https://mt.wikipedia.org/wiki/AIDS" title="AIDS – Maltese" lang="mt" hreflang="mt" data-title="AIDS" data-language-autonym="Malti" data-language-local-name="Maltese" class="interlanguage-link-target"><span>Malti</span></a></li><li class="interlanguage-link interwiki-mr mw-list-item"><a href="https://mr.wikipedia.org/wiki/%E0%A4%85%E0%A4%95%E0%A5%8D%E0%A4%B5%E0%A4%BE%E0%A4%AF%E0%A4%B0%E0%A5%8D%E0%A4%A1_%E0%A4%87%E0%A4%AE%E0%A5%8D%E0%A4%AF%E0%A5%82%E0%A4%A8%E0%A5%8B_%E0%A4%A1%E0%A5%87%E0%A4%AB%E0%A4%BF%E0%A4%B6%E0%A4%BF%E0%A4%AF%E0%A4%A8%E0%A5%8D%E0%A4%B8%E0%A5%80_%E0%A4%B8%E0%A4%BF%E0%A4%82%E0%A4%A1%E0%A5%8D%E0%A4%B0%E0%A5%8B%E0%A4%AE" title="अक्वायर्ड इम्यूनो डेफिशियन्सी सिंड्रोम – Marathi" lang="mr" hreflang="mr" data-title="अक्वायर्ड इम्यूनो डेफिशियन्सी सिंड्रोम" data-language-autonym="मराठी" data-language-local-name="Marathi" class="interlanguage-link-target"><span>मराठी</span></a></li><li class="interlanguage-link interwiki-xmf mw-list-item"><a href="https://xmf.wikipedia.org/wiki/%E1%83%A8%E1%83%98%E1%83%93%E1%83%A1%E1%83%98" title="შიდსი – Mingrelian" lang="xmf" hreflang="xmf" data-title="შიდსი" data-language-autonym="მარგალური" data-language-local-name="Mingrelian" class="interlanguage-link-target"><span>მარგალური</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/%D8%A7%D9%8A%D8%AF%D8%B2" title="ايدز – Egyptian Arabic" lang="arz" hreflang="arz" data-title="ايدز" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Malay" lang="ms" hreflang="ms" data-title="HIV/AIDS" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-cdo mw-list-item"><a href="https://cdo.wikipedia.org/wiki/%C3%81i-c%E1%B9%B3%CC%86-b%C3%A2ng" title="Ái-cṳ̆-bâng – Mindong" lang="cdo" hreflang="cdo" data-title="Ái-cṳ̆-bâng" data-language-autonym="閩東語 / Mìng-dĕ̤ng-ngṳ̄" data-language-local-name="Mindong" class="interlanguage-link-target"><span>閩東語 / Mìng-dĕ̤ng-ngṳ̄</span></a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%94%D0%B0%D1%80%D1%85%D0%BB%D0%B0%D0%BB%D1%8B%D0%BD_%D0%BE%D0%BB%D0%B4%D0%BC%D0%BE%D0%BB_%D1%85%D0%BE%D0%BC%D1%81%D0%B4%D0%BE%D0%BB" title="Дархлалын олдмол хомсдол – Mongolian" lang="mn" hreflang="mn" data-title="Дархлалын олдмол хомсдол" data-language-autonym="Монгол" data-language-local-name="Mongolian" class="interlanguage-link-target"><span>Монгол</span></a></li><li class="interlanguage-link interwiki-my mw-list-item"><a href="https://my.wikipedia.org/wiki/%E1%80%81%E1%80%AF%E1%80%81%E1%80%B6%E1%80%A1%E1%80%AC%E1%80%B8%E1%80%80%E1%80%BB%E1%80%86%E1%80%84%E1%80%BA%E1%80%B8%E1%80%99%E1%80%BE%E1%80%AF_%E1%80%80%E1%80%B0%E1%80%B8%E1%80%85%E1%80%80%E1%80%BA%E1%80%9B%E1%80%B1%E1%80%AC%E1%80%82%E1%80%AB" title="ခုခံအားကျဆင်းမှု ကူးစက်ရောဂါ – Burmese" lang="my" hreflang="my" data-title="ခုခံအားကျဆင်းမှု ကူးစက်ရောဂါ" data-language-autonym="မြန်မာဘာသာ" data-language-local-name="Burmese" class="interlanguage-link-target"><span>မြန်မာဘာသာ</span></a></li><li class="interlanguage-link interwiki-pcm mw-list-item"><a href="https://pcm.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Nigerian Pidgin" lang="pcm" hreflang="pcm" data-title="HIV/AIDS" data-language-autonym="Naijá" data-language-local-name="Nigerian Pidgin" class="interlanguage-link-target"><span>Naijá</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Aids" title="Aids – Dutch" lang="nl" hreflang="nl" data-title="Aids" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-nds-nl mw-list-item"><a href="https://nds-nl.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Low Saxon" lang="nds-NL" hreflang="nds-NL" data-title="HIV/AIDS" data-language-autonym="Nedersaksies" data-language-local-name="Low Saxon" class="interlanguage-link-target"><span>Nedersaksies</span></a></li><li class="interlanguage-link interwiki-ne mw-list-item"><a href="https://ne.wikipedia.org/wiki/%E0%A4%8F%E0%A4%A1%E0%A5%8D%E0%A4%B8" title="एड्स – Nepali" lang="ne" hreflang="ne" data-title="एड्स" data-language-autonym="नेपाली" data-language-local-name="Nepali" class="interlanguage-link-target"><span>नेपाली</span></a></li><li class="interlanguage-link interwiki-new mw-list-item"><a href="https://new.wikipedia.org/wiki/%E0%A4%8F%E0%A4%A1%E0%A5%8D%E0%A4%B8" title="एड्स – Newari" lang="new" hreflang="new" data-title="एड्स" data-language-autonym="नेपाल भाषा" data-language-local-name="Newari" class="interlanguage-link-target"><span>नेपाल भाषा</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E5%BE%8C%E5%A4%A9%E6%80%A7%E5%85%8D%E7%96%AB%E4%B8%8D%E5%85%A8%E7%97%87%E5%80%99%E7%BE%A4" title="後天性免疫不全症候群 – Japanese" lang="ja" hreflang="ja" data-title="後天性免疫不全症候群" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ce mw-list-item"><a href="https://ce.wikipedia.org/wiki/%D0%A2%D3%80%D0%B5%D1%8D%D1%86%D0%BD%D0%B0%D1%87%D1%83_%D0%B8%D0%BC%D0%BC%D1%83%D0%BD%D0%BE%D0%B4%D0%B5%D1%84%D0%B8%D1%86%D0%B8%D1%82%D0%B0%D0%BD_%D1%86%D0%B0%D0%BC%D0%B3%D0%B0%D1%80" title="ТӀеэцначу иммунодефицитан цамгар – Chechen" lang="ce" hreflang="ce" data-title="ТӀеэцначу иммунодефицитан цамгар" data-language-autonym="Нохчийн" data-language-local-name="Chechen" class="interlanguage-link-target"><span>Нохчийн</span></a></li><li class="interlanguage-link interwiki-frr mw-list-item"><a href="https://frr.wikipedia.org/wiki/AIDS" title="AIDS – Northern Frisian" lang="frr" hreflang="frr" data-title="AIDS" data-language-autonym="Nordfriisk" data-language-local-name="Northern Frisian" class="interlanguage-link-target"><span>Nordfriisk</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Aids" title="Aids – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Aids" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Hiv/aids" title="Hiv/aids – Norwegian Nynorsk" lang="nn" hreflang="nn" data-title="Hiv/aids" data-language-autonym="Norsk nynorsk" data-language-local-name="Norwegian Nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/SIDA" title="SIDA – Occitan" lang="oc" hreflang="oc" data-title="SIDA" data-language-autonym="Occitan" data-language-local-name="Occitan" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-mhr mw-list-item"><a href="https://mhr.wikipedia.org/wiki/%D0%9D%D0%98%D0%94%D0%A1" title="НИДС – Eastern Mari" lang="mhr" hreflang="mhr" data-title="НИДС" data-language-autonym="Олык марий" data-language-local-name="Eastern Mari" class="interlanguage-link-target"><span>Олык марий</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%8F%E0%AC%9A%E0%AC%86%E0%AC%87%E0%AC%AD%E0%AC%BF/%E0%AC%8F%E0%AC%A1%E0%AC%B8" title="ଏଚଆଇଭି/ଏଡସ – Odia" lang="or" hreflang="or" data-title="ଏଚଆଇଭି/ଏଡସ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Orttirilgan_immun_tanqisligi_sindromi" title="Orttirilgan immun tanqisligi sindromi – Uzbek" lang="uz" hreflang="uz" data-title="Orttirilgan immun tanqisligi sindromi" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-pa mw-list-item"><a href="https://pa.wikipedia.org/wiki/%E0%A8%8F%E0%A8%A1%E0%A8%9C%E0%A8%BC" title="ਏਡਜ਼ – Punjabi" lang="pa" hreflang="pa" data-title="ਏਡਜ਼" data-language-autonym="ਪੰਜਾਬੀ" data-language-local-name="Punjabi" class="interlanguage-link-target"><span>ਪੰਜਾਬੀ</span></a></li><li class="interlanguage-link interwiki-pnb mw-list-item"><a href="https://pnb.wikipedia.org/wiki/%D8%A7%DB%8C%DA%88%D8%B2" title="ایڈز – Western Punjabi" lang="pnb" hreflang="pnb" data-title="ایڈز" data-language-autonym="پنجابی" data-language-local-name="Western Punjabi" class="interlanguage-link-target"><span>پنجابی</span></a></li><li class="interlanguage-link interwiki-blk mw-list-item"><a href="https://blk.wikipedia.org/wiki/AIDS" title="AIDS – Pa&#039;O" lang="blk" hreflang="blk" data-title="AIDS" data-language-autonym="ပအိုဝ်ႏဘာႏသာႏ" data-language-local-name="Pa&#039;O" class="interlanguage-link-target"><span>ပအိုဝ်ႏဘာႏသာႏ</span></a></li><li class="interlanguage-link interwiki-pap mw-list-item"><a href="https://pap.wikipedia.org/wiki/Sida" title="Sida – Papiamento" lang="pap" hreflang="pap" data-title="Sida" data-language-autonym="Papiamentu" data-language-local-name="Papiamento" class="interlanguage-link-target"><span>Papiamentu</span></a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D8%A7%DB%90%DA%89%D8%B2" title="اېډز – Pashto" lang="ps" hreflang="ps" data-title="اېډز" data-language-autonym="پښتو" data-language-local-name="Pashto" class="interlanguage-link-target"><span>پښتو</span></a></li><li class="interlanguage-link interwiki-jam mw-list-item"><a href="https://jam.wikipedia.org/wiki/AIDS" title="AIDS – Jamaican Creole English" lang="jam" hreflang="jam" data-title="AIDS" data-language-autonym="Patois" data-language-local-name="Jamaican Creole English" class="interlanguage-link-target"><span>Patois</span></a></li><li class="interlanguage-link interwiki-km mw-list-item"><a href="https://km.wikipedia.org/wiki/%E1%9E%87%E1%9F%86%E1%9E%84%E1%9E%BA%E1%9E%A2%E1%9F%81%E1%9E%8A%E1%9E%9F%E1%9F%8D" title="ជំងឺអេដស៍ – Khmer" lang="km" hreflang="km" data-title="ជំងឺអេដស៍" data-language-autonym="ភាសាខ្មែរ" data-language-local-name="Khmer" class="interlanguage-link-target"><span>ភាសាខ្មែរ</span></a></li><li class="interlanguage-link interwiki-nds mw-list-item"><a href="https://nds.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Low German" lang="nds" hreflang="nds" data-title="HIV/AIDS" data-language-autonym="Plattdüütsch" data-language-local-name="Low German" class="interlanguage-link-target"><span>Plattdüütsch</span></a></li><li class="interlanguage-link interwiki-pl badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://pl.wikipedia.org/wiki/Zesp%C3%B3%C5%82_nabytego_niedoboru_odporno%C5%9Bci" title="Zespół nabytego niedoboru odporności – Polish" lang="pl" hreflang="pl" data-title="Zespół nabytego niedoboru odporności" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://pt.wikipedia.org/wiki/S%C3%ADndrome_da_imunodefici%C3%AAncia_adquirida" title="Síndrome da imunodeficiência adquirida – Portuguese" lang="pt" hreflang="pt" data-title="Síndrome da imunodeficiência adquirida" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/SIDA" title="SIDA – Romanian" lang="ro" hreflang="ro" data-title="SIDA" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-qu mw-list-item"><a href="https://qu.wikipedia.org/wiki/Unquy_hark%27aypa_chaskisqa_waqlliynin" title="Unquy hark&#039;aypa chaskisqa waqlliynin – Quechua" lang="qu" hreflang="qu" data-title="Unquy hark&#039;aypa chaskisqa waqlliynin" data-language-autonym="Runa Simi" data-language-local-name="Quechua" class="interlanguage-link-target"><span>Runa Simi</span></a></li><li class="interlanguage-link interwiki-rue mw-list-item"><a href="https://rue.wikipedia.org/wiki/%D0%90%D0%86%D0%94%D0%A1" title="АІДС – Rusyn" lang="rue" hreflang="rue" data-title="АІДС" data-language-autonym="Русиньскый" data-language-local-name="Rusyn" class="interlanguage-link-target"><span>Русиньскый</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A1%D0%B8%D0%BD%D0%B4%D1%80%D0%BE%D0%BC_%D0%BF%D1%80%D0%B8%D0%BE%D0%B1%D1%80%D0%B5%D1%82%D1%91%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B8%D0%BC%D0%BC%D1%83%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B4%D0%B5%D1%84%D0%B8%D1%86%D0%B8%D1%82%D0%B0" title="Синдром приобретённого иммунного дефицита – Russian" lang="ru" hreflang="ru" data-title="Синдром приобретённого иммунного дефицита" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sah mw-list-item"><a href="https://sah.wikipedia.org/wiki/%D0%A1%D0%9F%D0%98%D0%94" title="СПИД – Yakut" lang="sah" hreflang="sah" data-title="СПИД" data-language-autonym="Саха тыла" data-language-local-name="Yakut" class="interlanguage-link-target"><span>Саха тыла</span></a></li><li class="interlanguage-link interwiki-sa mw-list-item"><a href="https://sa.wikipedia.org/wiki/%E0%A4%8F%E0%A4%87%E0%A4%A1%E0%A5%8D%E0%A4%B8%E0%A5%8D" title="एइड्स् – Sanskrit" lang="sa" hreflang="sa" data-title="एइड्स्" data-language-autonym="संस्कृतम्" data-language-local-name="Sanskrit" class="interlanguage-link-target"><span>संस्कृतम्</span></a></li><li class="interlanguage-link interwiki-sc mw-list-item"><a href="https://sc.wikipedia.org/wiki/SIDA" title="SIDA – Sardinian" lang="sc" hreflang="sc" data-title="SIDA" data-language-autonym="Sardu" data-language-local-name="Sardinian" class="interlanguage-link-target"><span>Sardu</span></a></li><li class="interlanguage-link interwiki-sco mw-list-item"><a href="https://sco.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Scots" lang="sco" hreflang="sco" data-title="HIV/AIDS" data-language-autonym="Scots" data-language-local-name="Scots" class="interlanguage-link-target"><span>Scots</span></a></li><li class="interlanguage-link interwiki-sq mw-list-item"><a href="https://sq.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Albanian" lang="sq" hreflang="sq" data-title="HIV/AIDS" data-language-autonym="Shqip" data-language-local-name="Albanian" class="interlanguage-link-target"><span>Shqip</span></a></li><li class="interlanguage-link interwiki-scn mw-list-item"><a href="https://scn.wikipedia.org/wiki/AIDS" title="AIDS – Sicilian" lang="scn" hreflang="scn" data-title="AIDS" data-language-autonym="Sicilianu" data-language-local-name="Sicilian" class="interlanguage-link-target"><span>Sicilianu</span></a></li><li class="interlanguage-link interwiki-si mw-list-item"><a href="https://si.wikipedia.org/wiki/%E0%B6%92%E0%B6%A9%E0%B7%8A%E0%B7%83%E0%B7%8A" title="ඒඩ්ස් – Sinhala" lang="si" hreflang="si" data-title="ඒඩ්ස්" data-language-autonym="සිංහල" data-language-local-name="Sinhala" class="interlanguage-link-target"><span>සිංහල</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/AIDS" title="AIDS – Simple English" lang="en-simple" hreflang="en-simple" data-title="AIDS" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sd mw-list-item"><a href="https://sd.wikipedia.org/wiki/%D8%A7%D9%8A%DA%8A%D8%B2" title="ايڊز – Sindhi" lang="sd" hreflang="sd" data-title="ايڊز" data-language-autonym="سنڌي" data-language-local-name="Sindhi" class="interlanguage-link-target"><span>سنڌي</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Syndr%C3%B3m_z%C3%ADskanej_imunitnej_nedostato%C4%8Dnosti" title="Syndróm získanej imunitnej nedostatočnosti – Slovak" lang="sk" hreflang="sk" data-title="Syndróm získanej imunitnej nedostatočnosti" data-language-autonym="Slovenčina" data-language-local-name="Slovak" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Aids" title="Aids – Slovenian" lang="sl" hreflang="sl" data-title="Aids" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-so mw-list-item"><a href="https://so.wikipedia.org/wiki/AIDS" title="AIDS – Somali" lang="so" hreflang="so" data-title="AIDS" data-language-autonym="Soomaaliga" data-language-local-name="Somali" class="interlanguage-link-target"><span>Soomaaliga</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%D8%A6%D8%A7%DB%8C%D8%AF%D8%B2" title="ئایدز – Central Kurdish" lang="ckb" hreflang="ckb" data-title="ئایدز" data-language-autonym="کوردی" data-language-local-name="Central Kurdish" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-sr badge-Q17437796 badge-featuredarticle mw-list-item" title="featured article badge"><a href="https://sr.wikipedia.org/wiki/%D0%A1%D0%B8%D0%B4%D0%B0" title="Сида – Serbian" lang="sr" hreflang="sr" data-title="Сида" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/SIDA" title="SIDA – Serbo-Croatian" lang="sh" hreflang="sh" data-title="SIDA" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-su mw-list-item"><a href="https://su.wikipedia.org/wiki/AIDS" title="AIDS – Sundanese" lang="su" hreflang="su" data-title="AIDS" data-language-autonym="Sunda" data-language-local-name="Sundanese" class="interlanguage-link-target"><span>Sunda</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/AIDS" title="AIDS – Finnish" lang="fi" hreflang="fi" data-title="AIDS" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Aids" title="Aids – Swedish" lang="sv" hreflang="sv" data-title="Aids" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tl mw-list-item"><a href="https://tl.wikipedia.org/wiki/AIDS" title="AIDS – Tagalog" lang="tl" hreflang="tl" data-title="AIDS" data-language-autonym="Tagalog" data-language-local-name="Tagalog" class="interlanguage-link-target"><span>Tagalog</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%8E%E0%AE%AF%E0%AE%BF%E0%AE%9F%E0%AF%8D%E0%AE%9A%E0%AF%81" title="எயிட்சு – Tamil" lang="ta" hreflang="ta" data-title="எயிட்சு" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-shi mw-list-item"><a href="https://shi.wikipedia.org/wiki/Tama%E1%B8%8Dunt_n_SIDA" title="Tamaḍunt n SIDA – Tachelhit" lang="shi" hreflang="shi" data-title="Tamaḍunt n SIDA" data-language-autonym="Taclḥit" data-language-local-name="Tachelhit" class="interlanguage-link-target"><span>Taclḥit</span></a></li><li class="interlanguage-link interwiki-tt badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://tt.wikipedia.org/wiki/%D0%91%D0%98%D0%94%D0%A1" title="БИДС – Tatar" lang="tt" hreflang="tt" data-title="БИДС" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%8E%E0%B0%AF%E0%B0%BF%E0%B0%A1%E0%B1%8D%E0%B0%B8%E0%B1%8D" title="ఎయిడ్స్ – Telugu" lang="te" hreflang="te" data-title="ఎయిడ్స్" data-language-autonym="తెలుగు" data-language-local-name="Telugu" class="interlanguage-link-target"><span>తెలుగు</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%80%E0%B8%AD%E0%B8%94%E0%B8%AA%E0%B9%8C" title="เอดส์ – Thai" lang="th" hreflang="th" data-title="เอดส์" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-din mw-list-item"><a href="https://din.wikipedia.org/wiki/Adarwal" title="Adarwal – Dinka" lang="din" hreflang="din" data-title="Adarwal" data-language-autonym="Thuɔŋjäŋ" data-language-local-name="Dinka" class="interlanguage-link-target"><span>Thuɔŋjäŋ</span></a></li><li class="interlanguage-link interwiki-tg mw-list-item"><a href="https://tg.wikipedia.org/wiki/%D0%91%D0%9F%D0%9D%D0%9C" title="БПНМ – Tajik" lang="tg" hreflang="tg" data-title="БПНМ" data-language-autonym="Тоҷикӣ" data-language-local-name="Tajik" class="interlanguage-link-target"><span>Тоҷикӣ</span></a></li><li class="interlanguage-link interwiki-ve mw-list-item"><a href="https://ve.wikipedia.org/wiki/CIDA" title="CIDA – Venda" lang="ve" hreflang="ve" data-title="CIDA" data-language-autonym="Tshivenda" data-language-local-name="Venda" class="interlanguage-link-target"><span>Tshivenda</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Turkish" lang="tr" hreflang="tr" data-title="HIV/AIDS" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-tk mw-list-item"><a href="https://tk.wikipedia.org/wiki/AIDS" title="AIDS – Turkmen" lang="tk" hreflang="tk" data-title="AIDS" data-language-autonym="Türkmençe" data-language-local-name="Turkmen" class="interlanguage-link-target"><span>Türkmençe</span></a></li><li class="interlanguage-link interwiki-tw mw-list-item"><a href="https://tw.wikipedia.org/wiki/Babasoweremfo%C9%94" title="Babasoweremfoɔ – Twi" lang="tw" hreflang="tw" data-title="Babasoweremfoɔ" data-language-autonym="Twi" data-language-local-name="Twi" class="interlanguage-link-target"><span>Twi</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%92%D0%86%D0%9B/%D0%A1%D0%9D%D0%86%D0%94" title="ВІЛ/СНІД – Ukrainian" lang="uk" hreflang="uk" data-title="ВІЛ/СНІД" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-ur mw-list-item"><a href="https://ur.wikipedia.org/wiki/%D8%A7%DB%8C%DA%86_%D8%A2%D8%A6%DB%8C_%D9%88%DB%8C/%D8%A7%DB%8C%DA%88%D8%B2" title="ایچ آئی وی/ایڈز – Urdu" lang="ur" hreflang="ur" data-title="ایچ آئی وی/ایڈز" data-language-autonym="اردو" data-language-local-name="Urdu" class="interlanguage-link-target"><span>اردو</span></a></li><li class="interlanguage-link interwiki-za mw-list-item"><a href="https://za.wikipedia.org/wiki/Bingh%27aiswhbing" title="Bingh&#039;aiswhbing – Zhuang" lang="za" hreflang="za" data-title="Bingh&#039;aiswhbing" data-language-autonym="Vahcuengh" data-language-local-name="Zhuang" class="interlanguage-link-target"><span>Vahcuengh</span></a></li><li class="interlanguage-link interwiki-vec mw-list-item"><a href="https://vec.wikipedia.org/wiki/AIDS" title="AIDS – Venetian" lang="vec" hreflang="vec" data-title="AIDS" data-language-autonym="Vèneto" data-language-local-name="Venetian" class="interlanguage-link-target"><span>Vèneto</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Vietnamese" lang="vi" hreflang="vi" data-title="HIV/AIDS" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-fiu-vro mw-list-item"><a href="https://fiu-vro.wikipedia.org/wiki/AIDS" title="AIDS – Võro" lang="vro" hreflang="vro" data-title="AIDS" data-language-autonym="Võro" data-language-local-name="Võro" class="interlanguage-link-target"><span>Võro</span></a></li><li class="interlanguage-link interwiki-wa mw-list-item"><a href="https://wa.wikipedia.org/wiki/Sida" title="Sida – Walloon" lang="wa" hreflang="wa" data-title="Sida" data-language-autonym="Walon" data-language-local-name="Walloon" class="interlanguage-link-target"><span>Walon</span></a></li><li class="interlanguage-link interwiki-zh-classical mw-list-item"><a href="https://zh-classical.wikipedia.org/wiki/%E8%89%BE%E6%BB%8B%E7%97%85" title="艾滋病 – Literary Chinese" lang="lzh" hreflang="lzh" data-title="艾滋病" data-language-autonym="文言" data-language-local-name="Literary Chinese" class="interlanguage-link-target"><span>文言</span></a></li><li class="interlanguage-link interwiki-war mw-list-item"><a href="https://war.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Waray" lang="war" hreflang="war" data-title="HIV/AIDS" data-language-autonym="Winaray" data-language-local-name="Waray" class="interlanguage-link-target"><span>Winaray</span></a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E8%89%BE%E6%BB%8B%E7%97%85" title="艾滋病 – Wu" lang="wuu" hreflang="wuu" data-title="艾滋病" data-language-autonym="吴语" data-language-local-name="Wu" class="interlanguage-link-target"><span>吴语</span></a></li><li class="interlanguage-link interwiki-ts mw-list-item"><a href="https://ts.wikipedia.org/wiki/HIV/AIDS" title="HIV/AIDS – Tsonga" lang="ts" hreflang="ts" data-title="HIV/AIDS" data-language-autonym="Xitsonga" data-language-local-name="Tsonga" class="interlanguage-link-target"><span>Xitsonga</span></a></li><li class="interlanguage-link interwiki-yi mw-list-item"><a href="https://yi.wikipedia.org/wiki/%D7%A2%D7%99%D7%93%D7%A1" title="עידס – Yiddish" lang="yi" hreflang="yi" data-title="עידס" data-language-autonym="ייִדיש" data-language-local-name="Yiddish" class="interlanguage-link-target"><span>ייִדיש</span></a></li><li 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For other uses, see <a href="/wiki/AIDS_(disambiguation)" class="mw-disambig" title="AIDS (disambiguation)">AIDS (disambiguation)</a>.</div> <p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">HIV/AIDS</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">HIV disease, HIV infection<sup id="cite_ref-AIDS2010GOV_1-0" class="reference"><a href="#cite_note-AIDS2010GOV-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-AETC-staging_2-0" class="reference"><a href="#cite_note-AETC-staging-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><span typeof="mw:File"><a href="/wiki/File:Red_Ribbon.svg" class="mw-file-description"><img alt="A red ribbon in the shape of a bow" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Red_Ribbon.svg/220px-Red_Ribbon.svg.png" decoding="async" width="220" height="329" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Red_Ribbon.svg/330px-Red_Ribbon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/64/Red_Ribbon.svg/440px-Red_Ribbon.svg.png 2x" data-file-width="744" data-file-height="1112" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data">The <a href="/wiki/Red_ribbon#AIDS_awareness_origin" title="Red ribbon">red ribbon</a> is a <a href="/wiki/Awareness_ribbon#Awareness_Ribbon_origin" title="Awareness ribbon">symbol</a> for <a href="/wiki/Solidarity" title="Solidarity">solidarity</a> with <a href="/wiki/HIV-positive_people" title="HIV-positive people">HIV-positive people</a> and those living with AIDS.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Infectious_disease_(medical_specialty)" class="mw-redirect" title="Infectious disease (medical specialty)">Infectious disease</a>, <a href="/wiki/Immunology" title="Immunology">immunology</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Signs_and_symptoms" title="Signs and symptoms">Symptoms</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><b>Early</b>: Flu-like illness<sup id="cite_ref-WHO2015Fact_4-0" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></li> <li><b>Later</b>: <a href="/wiki/Large_lymph_nodes" class="mw-redirect" title="Large lymph nodes">Large lymph nodes</a>, fever, weight loss<sup id="cite_ref-WHO2015Fact_4-1" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Complication_(medicine)" title="Complication (medicine)">Complications</a></th><td class="infobox-data"><a href="/wiki/Opportunistic_infection" title="Opportunistic infection">Opportunistic infections</a>, <a href="/wiki/Neoplasm" title="Neoplasm">tumors</a><sup id="cite_ref-WHO2015Fact_4-2" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label">Duration</th><td class="infobox-data">Lifelong<sup id="cite_ref-WHO2015Fact_4-3" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label">Causes</th><td class="infobox-data"><a href="/wiki/Human_immunodeficiency_virus" class="mw-redirect" title="Human immunodeficiency virus">Human immunodeficiency virus</a> (HIV)<sup id="cite_ref-WHO2015Fact_4-4" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Risk_factor" title="Risk factor">Risk factors</a></th><td class="infobox-data"><a href="/wiki/Condom" title="Condom">Unprotected</a> <a href="/wiki/Anal_sex" title="Anal sex">anal</a> or <a href="/wiki/Sexual_intercourse" title="Sexual intercourse">vaginal sex</a>, having another <a href="/wiki/Sexually_transmitted_infection" title="Sexually transmitted infection">sexually transmitted infection</a>, <a href="/wiki/Needle_sharing" title="Needle sharing">needle sharing</a>, medical procedures involving <a href="/wiki/Sterilization_(microbiology)" title="Sterilization (microbiology)">unsterile</a> cutting or piercing, and experiencing <a href="/wiki/Needlestick_injury" title="Needlestick injury">needlestick injury</a><sup id="cite_ref-WHO2015Fact_4-5" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_diagnosis" title="Medical diagnosis">Diagnostic method</a></th><td class="infobox-data"><a href="/wiki/Blood_test" title="Blood test">Blood tests</a><sup id="cite_ref-WHO2015Fact_4-6" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label">Prevention</th><td class="infobox-data">Using <a href="/wiki/Condom" title="Condom">male</a> or <a href="/wiki/Female_condom" title="Female condom">female condom</a> during <a href="/wiki/Human_sexual_activity" title="Human sexual activity">sex</a>,<sup id="cite_ref-WHO2024Factsheet_5-0" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Diagnosis_of_HIV/AIDS" title="Diagnosis of HIV/AIDS">being tested for HIV</a> and <a href="/wiki/Sexually_transmitted_infection" title="Sexually transmitted infection">sexually transmitted infections</a>,<sup id="cite_ref-WHO2024Factsheet_5-1" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> having a <a href="/wiki/Circumcision_and_HIV" title="Circumcision and HIV">voluntary medical male circumcision</a>,<sup id="cite_ref-WHO2024Factsheet_5-2" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Needle_and_syringe_programmes" title="Needle and syringe programmes">using harm reduction services for people who inject and use drugs</a>,<sup id="cite_ref-WHO2024Factsheet_5-3" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Management_of_HIV/AIDS" title="Management of HIV/AIDS">antiretroviral drugs</a> (ARVs) (including <a href="/wiki/Pre-exposure_prophylaxis_for_HIV_prevention" title="Pre-exposure prophylaxis for HIV prevention">oral Pre-exposure prophylaxis (PrEP) and long acting products</a>,<sup id="cite_ref-WHO2024Factsheet_5-4" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Dapivirine_Ring" title="Dapivirine Ring">dapivirine vaginal rings</a>,<sup id="cite_ref-WHO2024Factsheet_5-5" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> injectable long acting <a href="/wiki/Cabotegravir" title="Cabotegravir">cabotegravir</a>, etc.<sup id="cite_ref-WHO2024Factsheet_5-6" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Post-exposure_prophylaxis" title="Post-exposure prophylaxis">post-exposure prophylaxis</a> (PEP)<sup id="cite_ref-WHO2024Factsheet_5-7" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Safe_sex" title="Safe sex">safe sex</a></td></tr><tr><th scope="row" class="infobox-label">Treatment</th><td class="infobox-data">Antiretroviral drugs (ARVs)<sup id="cite_ref-WHO2015Fact_4-7" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Prognosis" title="Prognosis">Prognosis</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li>Normal life expectancy with treatment<sup id="cite_ref-WHO2024Factsheet_5-8" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup></li> <li>11 years life expectancy without treatment<sup id="cite_ref-UNAIDS2007_6-0" class="reference"><a href="#cite_note-UNAIDS2007-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label">Frequency</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li>71.3–112.8 million total cases<sup id="cite_ref-UN2022_7-0" class="reference"><a href="#cite_note-UN2022-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup></li> <li>1.3 million new cases (2022)<sup id="cite_ref-UN2022_7-1" class="reference"><a href="#cite_note-UN2022-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup></li> <li>39.9 million living with HIV (2022)<sup id="cite_ref-UN2022_7-2" class="reference"><a href="#cite_note-UN2022-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label">Deaths</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li>42.3 million total deaths<sup id="cite_ref-UN2022_7-3" class="reference"><a href="#cite_note-UN2022-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup></li> <li>630,000 (2023)<sup id="cite_ref-UN2022_7-4" class="reference"><a href="#cite_note-UN2022-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup></li></ul> </div></td></tr></tbody></table> <p>The <b>human immunodeficiency virus</b> (<b>HIV</b>)<sup id="cite_ref-pmid11396444_8-0" class="reference"><a href="#cite_note-pmid11396444-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">&#91;</span>9<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">&#91;</span>10<span class="cite-bracket">&#93;</span></a></sup> is a <a href="/wiki/Retrovirus" title="Retrovirus">retrovirus</a><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">&#91;</span>11<span class="cite-bracket">&#93;</span></a></sup> that attacks the <a href="/wiki/Immune_system" title="Immune system">immune system</a>. It is a <a href="/wiki/Preventive_healthcare" title="Preventive healthcare">preventable disease</a>.<sup id="cite_ref-WHO2024Factsheet_5-9" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> There is no <a href="/wiki/Vaccine" title="Vaccine">vaccine</a> or <a href="/wiki/Cure" title="Cure">cure</a> for HIV. It can be managed with treatment and become a manageable chronic health condition.<sup id="cite_ref-WHO2024Factsheet_5-10" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> While there is no cure or vaccine, antiretroviral treatment can slow the course of the disease and enable people living with HIV to lead long and healthy lives.<sup id="cite_ref-WHO2024Factsheet_5-11" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-UN2012Vac_12-0" class="reference"><a href="#cite_note-UN2012Vac-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup> An HIV-positive person on treatment can expect to live a normal life, and die with the virus, not of it.<sup id="cite_ref-CDC21015Bas_13-0" class="reference"><a href="#cite_note-CDC21015Bas-13"><span class="cite-bracket">&#91;</span>13<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-UN2012Vac_12-1" class="reference"><a href="#cite_note-UN2012Vac-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup> Effective <a href="#Treatment">treatment</a> for <a href="/wiki/HIV-positive_people" title="HIV-positive people">HIV-positive people</a> (people living with <a href="/wiki/HIV" title="HIV">HIV</a>) involves a life-long regimen of medicine to suppress the virus, making the <a href="/wiki/Viral_load" title="Viral load">viral load</a> undetectable. Without treatment it can lead to a spectrum of conditions including <b>acquired immunodeficiency syndrome</b> (<b>AIDS</b>).<sup id="cite_ref-CDC21015Bas_13-1" class="reference"><a href="#cite_note-CDC21015Bas-13"><span class="cite-bracket">&#91;</span>13<span class="cite-bracket">&#93;</span></a></sup> </p><p>Treatment is recommended as soon as the diagnosis is made.<sup id="cite_ref-WHO2015Tx_14-0" class="reference"><a href="#cite_note-WHO2015Tx-14"><span class="cite-bracket">&#91;</span>14<span class="cite-bracket">&#93;</span></a></sup> An HIV-positive person who has an undetectable viral load as a result of long-term treatment has effectively no risk of transmitting HIV sexually.<sup id="cite_ref-CDCUndetectable_15-0" class="reference"><a href="#cite_note-CDCUndetectable-15"><span class="cite-bracket">&#91;</span>15<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Risk_of_sexual_transmission_of_huma_16-0" class="reference"><a href="#cite_note-Risk_of_sexual_transmission_of_huma-16"><span class="cite-bracket">&#91;</span>16<span class="cite-bracket">&#93;</span></a></sup> Campaigns by <a href="/wiki/Joint_United_Nations_Programme_on_HIV/AIDS" title="Joint United Nations Programme on HIV/AIDS">UNAIDS</a> and organizations around the world have communicated this as <a href="/wiki/Undetectable_%3D_Untransmittable" title="Undetectable = Untransmittable">Undetectable = Untransmittable</a>.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">&#91;</span>17<span class="cite-bracket">&#93;</span></a></sup> Without treatment the infection can interfere with the <a href="/wiki/Immune_system" title="Immune system">immune system</a>, and eventually <a href="#Signs_and_symptoms">progress to AIDS</a>, sometimes taking many years. Following initial infection an individual may not notice any symptoms, or may experience a brief period of <a href="/wiki/Influenza-like_illness" title="Influenza-like illness">influenza-like illness</a>.<sup id="cite_ref-WHO2015Fact_4-8" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> During this period the person may not know that they are HIV-positive, yet they will be able to <a href="#Sexual">pass on the virus</a>. Typically, this period is followed by a prolonged incubation period with no symptoms.<sup id="cite_ref-CDC21015Bas_13-2" class="reference"><a href="#cite_note-CDC21015Bas-13"><span class="cite-bracket">&#91;</span>13<span class="cite-bracket">&#93;</span></a></sup> Eventually the HIV infection increases the risk of developing other infections such as <a href="/wiki/Tuberculosis" title="Tuberculosis">tuberculosis</a>, as well as other <a href="/wiki/Opportunistic_infection" title="Opportunistic infection">opportunistic infections</a>, and <a href="/wiki/Tumors" class="mw-redirect" title="Tumors">tumors</a> which are rare in people who have normal immune function.<sup id="cite_ref-WHO2015Fact_4-9" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> The late stage is often also associated with <a href="/wiki/Cachexia" title="Cachexia">unintended weight loss</a>.<sup id="cite_ref-CDC21015Bas_13-3" class="reference"><a href="#cite_note-CDC21015Bas-13"><span class="cite-bracket">&#91;</span>13<span class="cite-bracket">&#93;</span></a></sup> Without treatment a person living with HIV can expect to live for 11 years.<sup id="cite_ref-UNAIDS2007_6-1" class="reference"><a href="#cite_note-UNAIDS2007-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> Early <a href="/wiki/HIV_testing" class="mw-redirect" title="HIV testing">testing</a> can show if treatment is needed to stop this progression and to prevent infecting others. </p><p>HIV is <a href="#Transmission">spread</a> primarily by <a href="/wiki/Unprotected_sex" class="mw-redirect" title="Unprotected sex">unprotected sex</a> (including <a href="/wiki/Anal_sex" title="Anal sex">anal</a> and <a href="/wiki/Vaginal_sex" class="mw-redirect" title="Vaginal sex">vaginal sex</a>), contaminated <a href="/wiki/Hypodermic_needle" title="Hypodermic needle">hypodermic needles</a> or <a href="/wiki/Blood_transfusion" title="Blood transfusion">blood transfusions</a>, and <a href="/wiki/Vertically_transmitted_infection" title="Vertically transmitted infection">from mother to child</a> during <a href="/wiki/HIV_and_pregnancy" title="HIV and pregnancy">pregnancy</a>, delivery, or breastfeeding.<sup id="cite_ref-TransmissionM2007_18-0" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> Some bodily fluids, such as saliva, sweat, and tears, do not transmit the virus.<sup id="cite_ref-CDCtransmission_19-0" class="reference"><a href="#cite_note-CDCtransmission-19"><span class="cite-bracket">&#91;</span>19<span class="cite-bracket">&#93;</span></a></sup> Oral sex has little risk of transmitting the virus.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">&#91;</span>20<span class="cite-bracket">&#93;</span></a></sup> Ways to avoid catching HIV and <a href="/wiki/Preventive_healthcare" title="Preventive healthcare">preventing the spread</a> include <a href="/wiki/Safe_sex" title="Safe sex">safe sex</a>, treatment to prevent infection ("<a href="/wiki/Pre-exposure_prophylaxis" title="Pre-exposure prophylaxis">PrEP</a>"), treatment to stop infection in someone who has been recently exposed ("<a href="/wiki/Post-exposure_prophylaxis" title="Post-exposure prophylaxis">PEP</a>"),<sup id="cite_ref-WHO2015Fact_4-10" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Treatment_as_prevention" title="Treatment as prevention">treating those who are infected</a>, and <a href="/wiki/Needle_exchange_program" class="mw-redirect" title="Needle exchange program">needle exchange programs</a>. Disease in a baby can often be prevented by giving both the mother and child <a href="/wiki/Management_of_HIV/AIDS" title="Management of HIV/AIDS">antiretroviral medication</a>.<sup id="cite_ref-WHO2015Fact_4-11" class="reference"><a href="#cite_note-WHO2015Fact-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p><p>Recognized worldwide in the early 1980s,<sup id="cite_ref-Gallo2_21-0" class="reference"><a href="#cite_note-Gallo2-21"><span class="cite-bracket">&#91;</span>21<span class="cite-bracket">&#93;</span></a></sup> HIV/AIDS has had a large impact on society, both as an illness and as a source of <a href="/wiki/Discrimination_against_people_with_HIV/AIDS" title="Discrimination against people with HIV/AIDS">discrimination</a>.<sup id="cite_ref-UNAIDS2006Ch4_22-0" class="reference"><a href="#cite_note-UNAIDS2006Ch4-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup> The disease also has large <a href="/wiki/Economic_impact_of_HIV/AIDS" title="Economic impact of HIV/AIDS">economic impacts</a>.<sup id="cite_ref-UNAIDS2006Ch4_22-1" class="reference"><a href="#cite_note-UNAIDS2006Ch4-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup> There are many <a href="/wiki/Misconceptions_about_HIV/AIDS" title="Misconceptions about HIV/AIDS">misconceptions about HIV/AIDS</a>, such as the belief that it can be transmitted by casual non-sexual contact.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">&#91;</span>23<span class="cite-bracket">&#93;</span></a></sup> The disease has become subject to many <a href="/wiki/Religion_and_HIV/AIDS" title="Religion and HIV/AIDS">controversies involving religion</a>, including the <a href="/wiki/Catholic_Church_and_HIV/AIDS" title="Catholic Church and HIV/AIDS">Catholic Church's position</a> not to support <a href="/wiki/Condom" title="Condom">condom</a> use as prevention.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">&#91;</span>24<span class="cite-bracket">&#93;</span></a></sup> It has attracted international medical and political attention as well as large-scale funding since it was identified in the 1980s.<sup id="cite_ref-isbn1-59797-294-0_25-0" class="reference"><a href="#cite_note-isbn1-59797-294-0-25"><span class="cite-bracket">&#91;</span>25<span class="cite-bracket">&#93;</span></a></sup> </p><p>HIV made the jump from other primates to humans in west-central Africa in the early-to-mid-20th century.<sup id="cite_ref-Orgin2011_26-0" class="reference"><a href="#cite_note-Orgin2011-26"><span class="cite-bracket">&#91;</span>26<span class="cite-bracket">&#93;</span></a></sup> AIDS was <a href="/wiki/History_of_HIV/AIDS" title="History of HIV/AIDS">first recognized</a> by the U.S. <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a> (CDC) in 1981 and its cause—HIV infection—was identified in the early part of the decade.<sup id="cite_ref-Gallo2_21-1" class="reference"><a href="#cite_note-Gallo2-21"><span class="cite-bracket">&#91;</span>21<span class="cite-bracket">&#93;</span></a></sup> Between the first time AIDS was readily identified through 2024, the disease is estimated to have caused at least 42.3 million deaths worldwide.<sup id="cite_ref-WHO2024Factsheet_5-12" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> In 2023, 630,000 people died from HIV-related causes, an estimated 1.3 million people acquired HIV and about 39.9 million people worldwide living with HIV, 65% of whom are in the <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (WHO) <a href="/wiki/Africa" title="Africa">African</a> Region.<sup id="cite_ref-WHO2024Factsheet_5-13" class="reference"><a href="#cite_note-WHO2024Factsheet-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-UN2022_7-5" class="reference"><a href="#cite_note-UN2022-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> HIV/AIDS is considered a <a href="/wiki/Pandemic#HIV/AIDS" title="Pandemic">pandemic</a>—a disease outbreak which is present over a large area and is actively spreading.<sup id="cite_ref-Kallings_27-0" class="reference"><a href="#cite_note-Kallings-27"><span class="cite-bracket">&#91;</span>27<span class="cite-bracket">&#93;</span></a></sup> The United States' National Institutes of Health (NIH) and the <a href="/wiki/Gates_Foundation" class="mw-redirect" title="Gates Foundation">Gates Foundation</a> have pledged $200 million focused on developing a global cure for AIDS.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">&#91;</span>28<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Signs_and_symptoms">Signs and symptoms</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Signs_and_symptoms_of_HIV/AIDS" title="Signs and symptoms of HIV/AIDS">Signs and symptoms of HIV/AIDS</a></div> <p>There are three main stages of <a href="/wiki/Human_immunodeficiency_virus" class="mw-redirect" title="Human immunodeficiency virus">HIV</a> infection: acute infection, clinical latency, and AIDS.<sup id="cite_ref-AIDS2010GOV_1-1" class="reference"><a href="#cite_note-AIDS2010GOV-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-M121_29-0" class="reference"><a href="#cite_note-M121-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="First_main_stage:_acute_infection">First main stage: acute infection</h3></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Symptoms_of_acute_HIV_infection.svg" class="mw-file-description"><img alt="A diagram of a human torso labeled with the most common symptoms of an acute HIV infection" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Symptoms_of_acute_HIV_infection.svg/280px-Symptoms_of_acute_HIV_infection.svg.png" decoding="async" width="280" height="250" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Symptoms_of_acute_HIV_infection.svg/420px-Symptoms_of_acute_HIV_infection.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Symptoms_of_acute_HIV_infection.svg/560px-Symptoms_of_acute_HIV_infection.svg.png 2x" data-file-width="1133" data-file-height="1012" /></a><figcaption>Main symptoms of acute HIV infection</figcaption></figure> <p>The initial period following infection with HIV is called acute HIV, primary HIV or acute retroviral syndrome.<sup id="cite_ref-M121_29-1" class="reference"><a href="#cite_note-M121-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-WHOCase2007_30-0" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> Many individuals develop an <a href="/wiki/Influenza-like_illness" title="Influenza-like illness">illness like influenza</a>, <a href="/wiki/Infectious_mononucleosis" title="Infectious mononucleosis">mononucleosis or glandular fever</a> 2–4 weeks after exposure while others have no significant symptoms.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">&#91;</span>31<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-M118_32-0" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> Symptoms occur in 40–90% of cases and most commonly include <a href="/wiki/Fever" title="Fever">fever</a>, <a href="/wiki/Lymphadenopathy" title="Lymphadenopathy">large tender lymph nodes</a>, <a href="/wiki/Pharyngitis" title="Pharyngitis">throat inflammation</a>, a <a href="/wiki/Rash" title="Rash">rash</a>, headache, tiredness, and/or sores of the mouth and genitals.<sup id="cite_ref-WHOCase2007_30-1" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-M118_32-1" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> The rash, which occurs in 20–50% of cases, presents itself on the trunk and is <a href="/wiki/Maculopapular" class="mw-redirect" title="Maculopapular">maculopapular</a>, classically.<sup id="cite_ref-Deut2010_33-0" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Some people also develop <a href="/wiki/Opportunistic_infections" class="mw-redirect" title="Opportunistic infections">opportunistic infections</a> at this stage.<sup id="cite_ref-WHOCase2007_30-2" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> Gastrointestinal symptoms, such as vomiting or <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a> may occur.<sup id="cite_ref-M118_32-2" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> Neurological symptoms of <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">peripheral neuropathy</a> or <a href="/wiki/Guillain%E2%80%93Barr%C3%A9_syndrome" title="Guillain–Barré syndrome">Guillain–Barré syndrome</a> also occur.<sup id="cite_ref-M118_32-3" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> The duration of the symptoms varies, but is usually one or two weeks.<sup id="cite_ref-M118_32-4" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> </p><p>These <a href="/wiki/Signs_and_symptoms" title="Signs and symptoms">symptoms</a> are not often <a href="/wiki/Medical_diagnosis#Pattern_recognition" title="Medical diagnosis">recognized</a> as signs of HIV infection. Family doctors or hospitals can misdiagnose cases as one of the many common <a href="/wiki/Infectious_disease" class="mw-redirect" title="Infectious disease">infectious diseases</a> with similar symptoms. Someone with an <a href="/wiki/Fever_of_unknown_origin" title="Fever of unknown origin">unexplained fever</a> who may have been recently exposed to HIV should consider testing to find out if they have been infected.<sup id="cite_ref-M118_32-5" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Second_main_stage:_clinical_latency">Second main stage: clinical latency</h3></div> <p>The initial symptoms are followed by a stage called clinical latency, asymptomatic HIV, or chronic HIV.<sup id="cite_ref-AIDS2010GOV_1-2" class="reference"><a href="#cite_note-AIDS2010GOV-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Without treatment, this second stage of the <a href="/wiki/Natural_history_of_disease" title="Natural history of disease">natural history</a> of HIV infection can last from about three years<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">&#91;</span>34<span class="cite-bracket">&#93;</span></a></sup> to over 20&#160;years<sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">&#91;</span>35<span class="cite-bracket">&#93;</span></a></sup> (on average, about eight years).<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">&#91;</span>36<span class="cite-bracket">&#93;</span></a></sup> While typically there are few or no symptoms at first, near the end of this stage many people experience fever, weight loss, gastrointestinal problems and muscle pains.<sup id="cite_ref-AIDS2010GOV_1-3" class="reference"><a href="#cite_note-AIDS2010GOV-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Between 50% and 70% of people also develop <a href="/wiki/Persistent_generalized_lymphadenopathy" title="Persistent generalized lymphadenopathy">persistent generalized lymphadenopathy</a>, characterized by unexplained, non-painful enlargement of more than one group of lymph nodes (other than in the groin) for over three to six months.<sup id="cite_ref-M121_29-2" class="reference"><a href="#cite_note-M121-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup> </p><p>Although most <a href="/wiki/HIV-1" class="mw-redirect" title="HIV-1">HIV-1</a> infected individuals have a detectable viral load and in the absence of treatment will eventually progress to AIDS, a small proportion (about 5%) retain high levels of <a href="/wiki/CD4" title="CD4">CD4</a><sup>+</sup> T cells (<a href="/wiki/T_helper_cell" title="T helper cell">T helper cells</a>) without <a href="/wiki/Management_of_HIV/AIDS" title="Management of HIV/AIDS">antiretroviral therapy</a> for more than five years.<sup id="cite_ref-M118_32-6" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-LT2010_37-0" class="reference"><a href="#cite_note-LT2010-37"><span class="cite-bracket">&#91;</span>37<span class="cite-bracket">&#93;</span></a></sup> These individuals are classified as "HIV controllers" or <a href="/wiki/Long-term_nonprogressors" class="mw-redirect" title="Long-term nonprogressors">long-term nonprogressors</a> (LTNP).<sup id="cite_ref-LT2010_37-1" class="reference"><a href="#cite_note-LT2010-37"><span class="cite-bracket">&#91;</span>37<span class="cite-bracket">&#93;</span></a></sup> Another group consists of those who maintain a low or undetectable viral load without anti-retroviral treatment, known as "elite controllers" or "elite suppressors". They represent approximately 1 in 300 infected persons.<sup id="cite_ref-Walker2007_38-0" class="reference"><a href="#cite_note-Walker2007-38"><span class="cite-bracket">&#91;</span>38<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Third_main_stage:_AIDS">Third main stage: AIDS</h3></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Symptoms_of_AIDS.svg" class="mw-file-description"><img alt="A diagram of a human torso labeled with the most common symptoms of AIDS" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6b/Symptoms_of_AIDS.svg/280px-Symptoms_of_AIDS.svg.png" decoding="async" width="280" height="338" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6b/Symptoms_of_AIDS.svg/420px-Symptoms_of_AIDS.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6b/Symptoms_of_AIDS.svg/560px-Symptoms_of_AIDS.svg.png 2x" data-file-width="882" data-file-height="1066" /></a><figcaption>Main symptoms of AIDS</figcaption></figure> <p>Acquired immunodeficiency syndrome (AIDS) is defined as an HIV infection with either a CD4<sup>+</sup> T cell count below 200 cells per μL or the occurrence of specific diseases associated with HIV infection.<sup id="cite_ref-M118_32-7" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> In the absence of specific treatment, around half of people infected with HIV develop AIDS within ten years.<sup id="cite_ref-M118_32-8" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> The most common initial conditions that alert to the presence of AIDS are <a href="/wiki/Pneumocystis_pneumonia" title="Pneumocystis pneumonia">pneumocystis pneumonia</a> (40%), <a href="/wiki/Cachexia" title="Cachexia">cachexia</a> in the form of HIV wasting syndrome (20%), and <a href="/wiki/Esophageal_candidiasis" title="Esophageal candidiasis">esophageal candidiasis</a>.<sup id="cite_ref-M118_32-9" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> Other common signs include recurrent <a href="/wiki/Respiratory_tract_infection" title="Respiratory tract infection">respiratory tract infections</a>.<sup id="cite_ref-M118_32-10" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> </p><p><a href="/wiki/Opportunistic_infections" class="mw-redirect" title="Opportunistic infections">Opportunistic infections</a> may be caused by <a href="/wiki/Bacteria" title="Bacteria">bacteria</a>, <a href="/wiki/Virus" title="Virus">viruses</a>, <a href="/wiki/Fungi" class="mw-redirect" title="Fungi">fungi</a>, and <a href="/wiki/Parasite" class="mw-redirect" title="Parasite">parasites</a> that are normally controlled by the immune system.<sup id="cite_ref-Holmes_39-0" class="reference"><a href="#cite_note-Holmes-39"><span class="cite-bracket">&#91;</span>39<span class="cite-bracket">&#93;</span></a></sup> Which infections occur depends partly on what organisms are common in the person's environment.<sup id="cite_ref-M118_32-11" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> These infections may affect nearly every <a href="/wiki/Biological_system" title="Biological system">organ system</a>.<sup id="cite_ref-Complications2011_40-0" class="reference"><a href="#cite_note-Complications2011-40"><span class="cite-bracket">&#91;</span>40<span class="cite-bracket">&#93;</span></a></sup> </p><p>People with AIDS have an increased risk of developing various viral-induced cancers, including <a href="/wiki/Kaposi%27s_sarcoma" title="Kaposi&#39;s sarcoma">Kaposi's sarcoma</a>, <a href="/wiki/Burkitt%27s_lymphoma" class="mw-redirect" title="Burkitt&#39;s lymphoma">Burkitt's lymphoma</a>, <a href="/wiki/Primary_central_nervous_system_lymphoma" title="Primary central nervous system lymphoma">primary central nervous system lymphoma</a>, and <a href="/wiki/Cervical_cancer" title="Cervical cancer">cervical cancer</a>.<sup id="cite_ref-Deut2010_33-1" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Kaposi's sarcoma is the most common cancer, occurring in 10% to 20% of people with HIV.<sup id="cite_ref-M169_41-0" class="reference"><a href="#cite_note-M169-41"><span class="cite-bracket">&#91;</span>41<span class="cite-bracket">&#93;</span></a></sup> The second-most common cancer is lymphoma, which is the cause of death of nearly 16% of people with AIDS and is the initial sign of AIDS in 3% to 4%.<sup id="cite_ref-M169_41-1" class="reference"><a href="#cite_note-M169-41"><span class="cite-bracket">&#91;</span>41<span class="cite-bracket">&#93;</span></a></sup> Both these cancers are associated with <a href="/wiki/Kaposi%27s_sarcoma-associated_herpesvirus" title="Kaposi&#39;s sarcoma-associated herpesvirus">human herpesvirus 8</a> (HHV-8).<sup id="cite_ref-M169_41-2" class="reference"><a href="#cite_note-M169-41"><span class="cite-bracket">&#91;</span>41<span class="cite-bracket">&#93;</span></a></sup> Cervical cancer occurs more frequently in those with AIDS because of its association with <a href="/wiki/Human_papillomavirus" class="mw-redirect" title="Human papillomavirus">human papillomavirus</a> (HPV).<sup id="cite_ref-M169_41-3" class="reference"><a href="#cite_note-M169-41"><span class="cite-bracket">&#91;</span>41<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Conjunctiva" title="Conjunctiva">Conjunctival cancer</a> (of the layer that lines the inner part of eyelids and the white part of the eye) is also more common in those with HIV.<sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">&#91;</span>42<span class="cite-bracket">&#93;</span></a></sup> </p><p>Additionally, people with AIDS frequently have systemic symptoms such as prolonged fevers, <a href="/wiki/Night_sweats" title="Night sweats">sweats</a> (particularly at night), swollen lymph nodes, chills, weakness, and <a href="/wiki/Cachexia" title="Cachexia">unintended weight loss</a>.<sup id="cite_ref-43" class="reference"><a href="#cite_note-43"><span class="cite-bracket">&#91;</span>43<span class="cite-bracket">&#93;</span></a></sup> Diarrhea is another common symptom, present in about 90% of people with AIDS.<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">&#91;</span>44<span class="cite-bracket">&#93;</span></a></sup> They can also be affected by diverse psychiatric and neurological symptoms independent of opportunistic infections and cancers.<sup id="cite_ref-45" class="reference"><a href="#cite_note-45"><span class="cite-bracket">&#91;</span>45<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Transmission">Transmission</h2></div> <table class="wikitable" style="float:right; clear:right; font-size:85%; margin-left:15px;"> <caption>Average per act risk of getting HIV<br />by exposure route to an infected source </caption> <tbody><tr style="background:#efefef;"> <th style="width: 100px" abbr="Route">Exposure route </th> <th style="width: 130px" abbr="Infections">Chance of infection </th></tr> <tr> <th style="text-align: left">Blood transfusion </th> <td>90%<sup id="cite_ref-Blood_Transfusion_Risk_46-0" class="reference"><a href="#cite_note-Blood_Transfusion_Risk-46"><span class="cite-bracket">&#91;</span>46<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Childbirth <small>(to child)</small> </th> <td>25%<sup id="cite_ref-Coovadia_47-0" class="reference"><a href="#cite_note-Coovadia-47"><span class="cite-bracket">&#91;</span>47<span class="cite-bracket">&#93;</span></a></sup><sup class="noprint Inline-Template" style="margin-left:0.1em; white-space:nowrap;">&#91;<i><a href="/wiki/Wikipedia:Please_clarify" title="Wikipedia:Please clarify"><span title="This is only concerning highly active antiretroviral therapy or HAART (January 2019)">clarification needed</span></a></i>&#93;</sup> </td></tr> <tr> <th style="text-align: left">Needle-sharing injection drug use </th> <td>0.67%<sup id="cite_ref-MMWR2005_48-0" class="reference"><a href="#cite_note-MMWR2005-48"><span class="cite-bracket">&#91;</span>48<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Percutaneous needle stick </th> <td>0.30%<sup id="cite_ref-AFP2007_49-0" class="reference"><a href="#cite_note-AFP2007-49"><span class="cite-bracket">&#91;</span>49<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Receptive anal intercourse<sup>*</sup> </th> <td>0.04–3.0%<sup id="cite_ref-Trans2010_50-0" class="reference"><a href="#cite_note-Trans2010-50"><span class="cite-bracket">&#91;</span>50<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Insertive anal intercourse<sup>*</sup> </th> <td>0.03%<sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">&#91;</span>51<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Receptive penile-vaginal intercourse<sup>*</sup> </th> <td>0.05–0.30%<sup id="cite_ref-Trans2010_50-1" class="reference"><a href="#cite_note-Trans2010-50"><span class="cite-bracket">&#91;</span>50<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-LancetT2009_52-0" class="reference"><a href="#cite_note-LancetT2009-52"><span class="cite-bracket">&#91;</span>52<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Insertive penile-vaginal intercourse<sup>*</sup> </th> <td>0.01–0.38%<sup id="cite_ref-Trans2010_50-2" class="reference"><a href="#cite_note-Trans2010-50"><span class="cite-bracket">&#91;</span>50<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-LancetT2009_52-1" class="reference"><a href="#cite_note-LancetT2009-52"><span class="cite-bracket">&#91;</span>52<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Receptive oral intercourse<sup>*§</sup> </th> <td>0–0.04%<sup id="cite_ref-Trans2010_50-3" class="reference"><a href="#cite_note-Trans2010-50"><span class="cite-bracket">&#91;</span>50<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr> <th style="text-align: left">Insertive oral intercourse<sup>*§</sup> </th> <td>0–0.005%<sup id="cite_ref-53" class="reference"><a href="#cite_note-53"><span class="cite-bracket">&#91;</span>53<span class="cite-bracket">&#93;</span></a></sup> </td></tr> <tr style="background:#efefef;"> <th colspan="5" style="border-right:0;"><sup>*</sup> assuming no condom use <br /> <sup>§</sup> source refers to oral intercourse<br />performed on a man </th></tr></tbody></table> <p>HIV is spread by three main routes: <a href="/wiki/Human_sexual_activity" title="Human sexual activity">sexual contact</a>, significant exposure to infected body fluids or tissues, and from mother to child during pregnancy, delivery, or breastfeeding (known as <a href="/wiki/Vertical_transmission" title="Vertical transmission">vertical transmission</a>).<sup id="cite_ref-TransmissionM2007_18-1" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> There is no risk of acquiring HIV if exposed to <a href="/wiki/Feces" title="Feces">feces</a>, nasal secretions, saliva, <a href="/wiki/Sputum" title="Sputum">sputum</a>, sweat, tears, urine, or vomit unless these are contaminated with blood.<sup id="cite_ref-AFP2007k_54-0" class="reference"><a href="#cite_note-AFP2007k-54"><span class="cite-bracket">&#91;</span>54<span class="cite-bracket">&#93;</span></a></sup> It is also possible to be <a href="/wiki/Coinfection" title="Coinfection">co-infected</a> by more than one strain of HIV—a condition known as <a href="/wiki/HIV_superinfection" title="HIV superinfection">HIV superinfection</a>.<sup id="cite_ref-55" class="reference"><a href="#cite_note-55"><span class="cite-bracket">&#91;</span>55<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Sexual">Sexual</h3></div> <p>The most frequent mode of transmission of HIV is through sexual contact with an infected person.<sup id="cite_ref-TransmissionM2007_18-2" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> However, an HIV-positive person who has an undetectable viral load as a result of long-term treatment has effectively no risk of transmitting HIV sexually, known as <a href="/wiki/Undetectable_%3D_Untransmittable" title="Undetectable = Untransmittable">Undetectable = Untransmittable</a>.<sup id="cite_ref-CDCUndetectable_15-1" class="reference"><a href="#cite_note-CDCUndetectable-15"><span class="cite-bracket">&#91;</span>15<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Risk_of_sexual_transmission_of_huma_16-1" class="reference"><a href="#cite_note-Risk_of_sexual_transmission_of_huma-16"><span class="cite-bracket">&#91;</span>16<span class="cite-bracket">&#93;</span></a></sup> The existence of functionally noncontagious HIV-positive people on antiretroviral therapy was controversially publicized in the 2008 <a href="/wiki/Swiss_Statement" title="Swiss Statement">Swiss Statement</a>, and has since become accepted as medically sound.<sup id="cite_ref-56" class="reference"><a href="#cite_note-56"><span class="cite-bracket">&#91;</span>56<span class="cite-bracket">&#93;</span></a></sup> </p><p>Globally, the most common mode of HIV transmission is via <a href="/wiki/Heterosexuality" title="Heterosexuality">sexual contacts between people of the opposite sex</a>;<sup id="cite_ref-TransmissionM2007_18-3" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> however, the pattern of transmission varies among countries. As of 2017<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=HIV/AIDS&amp;action=edit">&#91;update&#93;</a></sup>, most HIV transmission in the United States occurred among <a href="/wiki/Men_who_had_sex_with_men" class="mw-redirect" title="Men who had sex with men">men who had sex with men</a> (82% of new HIV diagnoses among males aged 13 and older and 70% of total new diagnoses).<sup id="cite_ref-57" class="reference"><a href="#cite_note-57"><span class="cite-bracket">&#91;</span>57<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-58" class="reference"><a href="#cite_note-58"><span class="cite-bracket">&#91;</span>58<span class="cite-bracket">&#93;</span></a></sup> In the US, gay and bisexual men aged 13 to 24 accounted for an estimated 92% of new HIV diagnoses among all men in their age group and 27% of new diagnoses among all gay and bisexual men.<sup id="cite_ref-CDC2016Bi_59-0" class="reference"><a href="#cite_note-CDC2016Bi-59"><span class="cite-bracket">&#91;</span>59<span class="cite-bracket">&#93;</span></a></sup> </p><p>With regard to <a href="/wiki/Unprotected_sex" class="mw-redirect" title="Unprotected sex">unprotected</a> heterosexual contacts, estimates of the risk of HIV transmission per sexual act appear to be four to ten times higher in low-income countries than in high-income countries.<sup id="cite_ref-Boily2009_60-0" class="reference"><a href="#cite_note-Boily2009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup> In low-income countries, the risk of female-to-male transmission is estimated as 0.38% per act, and of male-to-female transmission as 0.30% per act; the equivalent estimates for high-income countries are 0.04% per act for female-to-male transmission, and 0.08% per act for male-to-female transmission.<sup id="cite_ref-Boily2009_60-1" class="reference"><a href="#cite_note-Boily2009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup> The risk of transmission from anal intercourse is especially high, estimated as 1.4–1.7% per act in both heterosexual and homosexual contacts.<sup id="cite_ref-Boily2009_60-2" class="reference"><a href="#cite_note-Boily2009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-61" class="reference"><a href="#cite_note-61"><span class="cite-bracket">&#91;</span>61<span class="cite-bracket">&#93;</span></a></sup> While the risk of transmission from <a href="/wiki/Oral_sex" title="Oral sex">oral sex</a> is relatively low, it is still present.<sup id="cite_ref-62" class="reference"><a href="#cite_note-62"><span class="cite-bracket">&#91;</span>62<span class="cite-bracket">&#93;</span></a></sup> The risk from receiving oral sex has been described as "nearly nil";<sup id="cite_ref-63" class="reference"><a href="#cite_note-63"><span class="cite-bracket">&#91;</span>63<span class="cite-bracket">&#93;</span></a></sup> however, a few cases have been reported.<sup id="cite_ref-64" class="reference"><a href="#cite_note-64"><span class="cite-bracket">&#91;</span>64<span class="cite-bracket">&#93;</span></a></sup> The per-act risk is estimated at 0–0.04% for receptive oral intercourse.<sup id="cite_ref-Dosekun2010_65-0" class="reference"><a href="#cite_note-Dosekun2010-65"><span class="cite-bracket">&#91;</span>65<span class="cite-bracket">&#93;</span></a></sup> In settings involving <a href="/wiki/Prostitution" title="Prostitution">prostitution</a> in low-income countries, risk of female-to-male transmission has been estimated as 2.4% per act, and of male-to-female transmission as 0.05% per act.<sup id="cite_ref-Boily2009_60-3" class="reference"><a href="#cite_note-Boily2009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup> </p><p>Risk of transmission increases in the presence of many <a href="/wiki/Sexually_transmitted_infection" title="Sexually transmitted infection">sexually transmitted infections</a><sup id="cite_ref-CochraneSTI2012_66-0" class="reference"><a href="#cite_note-CochraneSTI2012-66"><span class="cite-bracket">&#91;</span>66<span class="cite-bracket">&#93;</span></a></sup> and <a href="/wiki/Genital_ulcer" title="Genital ulcer">genital ulcers</a>.<sup id="cite_ref-Boily2009_60-4" class="reference"><a href="#cite_note-Boily2009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup> Genital ulcers increase the risk approximately fivefold.<sup id="cite_ref-Boily2009_60-5" class="reference"><a href="#cite_note-Boily2009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup> Other sexually transmitted infections, such as <a href="/wiki/Gonorrhea" title="Gonorrhea">gonorrhea</a>, <a href="/wiki/Chlamydia_infection" class="mw-redirect" title="Chlamydia infection">chlamydia</a>, <a href="/wiki/Trichomoniasis" title="Trichomoniasis">trichomoniasis</a>, and <a href="/wiki/Bacterial_vaginosis" title="Bacterial vaginosis">bacterial vaginosis</a>, are associated with somewhat smaller increases in risk of transmission.<sup id="cite_ref-Dosekun2010_65-1" class="reference"><a href="#cite_note-Dosekun2010-65"><span class="cite-bracket">&#91;</span>65<span class="cite-bracket">&#93;</span></a></sup> </p><p>The <a href="/wiki/Viral_load" title="Viral load">viral load</a> of an infected person is an important risk factor in both sexual and mother-to-child transmission.<sup id="cite_ref-67" class="reference"><a href="#cite_note-67"><span class="cite-bracket">&#91;</span>67<span class="cite-bracket">&#93;</span></a></sup> During the first 2.5&#160;months of an HIV infection, a person's infectiousness is twelve times higher due to the high viral load associated with acute HIV.<sup id="cite_ref-Dosekun2010_65-2" class="reference"><a href="#cite_note-Dosekun2010-65"><span class="cite-bracket">&#91;</span>65<span class="cite-bracket">&#93;</span></a></sup> If the person is in the late stages of infection, rates of transmission are approximately eightfold greater.<sup id="cite_ref-Boily2009_60-6" class="reference"><a href="#cite_note-Boily2009-60"><span class="cite-bracket">&#91;</span>60<span class="cite-bracket">&#93;</span></a></sup> </p><p>Commercial sex workers (including <a href="/wiki/Sexually_transmitted_infections_in_the_pornography_industry" title="Sexually transmitted infections in the pornography industry">those in pornography</a>) have an increased likelihood of contracting HIV.<sup id="cite_ref-68" class="reference"><a href="#cite_note-68"><span class="cite-bracket">&#91;</span>68<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-69" class="reference"><a href="#cite_note-69"><span class="cite-bracket">&#91;</span>69<span class="cite-bracket">&#93;</span></a></sup> Rough sex can be a factor associated with an increased risk of transmission.<sup id="cite_ref-70" class="reference"><a href="#cite_note-70"><span class="cite-bracket">&#91;</span>70<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Sexual_assault" title="Sexual assault">Sexual assault</a> is also believed to carry an increased risk of HIV transmission as condoms are rarely worn, physical trauma to the vagina or rectum is likely, and there may be a greater risk of concurrent sexually transmitted infections.<sup id="cite_ref-71" class="reference"><a href="#cite_note-71"><span class="cite-bracket">&#91;</span>71<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Body_fluids">Body fluids</h3></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:AIDS_Poster_If_You%27re_Dabbling_in_Drugs_1989.jpg" class="mw-file-description"><img alt="A black-and-white poster of a young black man with a towel in his left hand with the words &quot;If you are dabbling with drugs you could be dabbling with your life&quot; above him" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/AIDS_Poster_If_You%27re_Dabbling_in_Drugs_1989.jpg/220px-AIDS_Poster_If_You%27re_Dabbling_in_Drugs_1989.jpg" decoding="async" width="220" height="298" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/AIDS_Poster_If_You%27re_Dabbling_in_Drugs_1989.jpg/330px-AIDS_Poster_If_You%27re_Dabbling_in_Drugs_1989.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bd/AIDS_Poster_If_You%27re_Dabbling_in_Drugs_1989.jpg/440px-AIDS_Poster_If_You%27re_Dabbling_in_Drugs_1989.jpg 2x" data-file-width="937" data-file-height="1269" /></a><figcaption>CDC poster from 1989 highlighting the threat of AIDS associated with drug use</figcaption></figure> <p>The second-most frequent mode of HIV transmission is via blood and blood products.<sup id="cite_ref-TransmissionM2007_18-4" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> Blood-borne transmission can be through needle-sharing during intravenous drug use, needle-stick injury, transfusion of contaminated blood or blood product, or medical injections with unsterilized equipment. The risk from sharing a needle during <a href="/wiki/Drug_injection" title="Drug injection">drug injection</a> is between 0.63% and 2.4% per act, with an average of 0.8%.<sup id="cite_ref-Risk2006_72-0" class="reference"><a href="#cite_note-Risk2006-72"><span class="cite-bracket">&#91;</span>72<span class="cite-bracket">&#93;</span></a></sup> The risk of acquiring HIV from a needle stick from an HIV-infected person is estimated as 0.3% (about 1 in 333) per act and the risk following <a href="/wiki/Mucous_membrane" title="Mucous membrane">mucous membrane</a> exposure to infected blood as 0.09% (about 1 in 1000) per act.<sup id="cite_ref-AFP2007k_54-1" class="reference"><a href="#cite_note-AFP2007k-54"><span class="cite-bracket">&#91;</span>54<span class="cite-bracket">&#93;</span></a></sup> This risk may, however, be up to 5% if the introduced blood was from a person with a high viral load and the cut was deep.<sup id="cite_ref-Needle2002_73-0" class="reference"><a href="#cite_note-Needle2002-73"><span class="cite-bracket">&#91;</span>73<span class="cite-bracket">&#93;</span></a></sup> In the United States, intravenous drug users made up 12% of all new cases of HIV in 2009,<sup id="cite_ref-TransmissionCDC2012_74-0" class="reference"><a href="#cite_note-TransmissionCDC2012-74"><span class="cite-bracket">&#91;</span>74<span class="cite-bracket">&#93;</span></a></sup> and in some areas more than 80% of people who inject drugs are HIV-positive.<sup id="cite_ref-TransmissionM2007_18-5" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> </p><p>HIV is transmitted in about 90% of <a href="/wiki/Blood_transfusion" title="Blood transfusion">blood transfusions</a> using infected blood.<sup id="cite_ref-Blood_Transfusion_Risk_46-1" class="reference"><a href="#cite_note-Blood_Transfusion_Risk-46"><span class="cite-bracket">&#91;</span>46<span class="cite-bracket">&#93;</span></a></sup> In developed countries the risk of acquiring HIV from a blood transfusion is extremely low (less than one in half a million) where improved donor selection and <a href="/wiki/HIV_screening" class="mw-redirect" title="HIV screening">HIV screening</a> is performed;<sup id="cite_ref-TransmissionM2007_18-6" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup> for example, in the UK the risk is reported at one in five million<sup id="cite_ref-75" class="reference"><a href="#cite_note-75"><span class="cite-bracket">&#91;</span>75<span class="cite-bracket">&#93;</span></a></sup> and in the United States it was one in 1.5&#160;million in 2008.<sup id="cite_ref-76" class="reference"><a href="#cite_note-76"><span class="cite-bracket">&#91;</span>76<span class="cite-bracket">&#93;</span></a></sup> In low-income countries, only half of transfusions may be appropriately screened (as of 2008),<sup id="cite_ref-UN2011Seventy_77-0" class="reference"><a href="#cite_note-UN2011Seventy-77"><span class="cite-bracket">&#91;</span>77<span class="cite-bracket">&#93;</span></a></sup> and it is estimated that up to 15% of HIV infections in these areas come from transfusion of infected blood and blood products, representing between 5% and 10% of global infections.<sup id="cite_ref-TransmissionM2007_18-7" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-WHO070401_78-0" class="reference"><a href="#cite_note-WHO070401-78"><span class="cite-bracket">&#91;</span>78<span class="cite-bracket">&#93;</span></a></sup> It is possible to acquire HIV from organ and tissue <a href="/wiki/Organ_transplantation" title="Organ transplantation">transplantation</a>, although this is rare because of <a href="/wiki/Diagnosis_of_HIV/AIDS" title="Diagnosis of HIV/AIDS">screening</a>.<sup id="cite_ref-79" class="reference"><a href="#cite_note-79"><span class="cite-bracket">&#91;</span>79<span class="cite-bracket">&#93;</span></a></sup> </p><p>Unsafe medical injections play a role in <a href="/wiki/HIV/AIDS_in_Africa" title="HIV/AIDS in Africa">HIV spread in sub-Saharan Africa</a>. In 2007, between 12% and 17% of infections in this region were attributed to medical syringe use.<sup id="cite_ref-UnsafeInjection2009_80-0" class="reference"><a href="#cite_note-UnsafeInjection2009-80"><span class="cite-bracket">&#91;</span>80<span class="cite-bracket">&#93;</span></a></sup> The <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> estimates the risk of transmission as a result of a medical injection in Africa at 1.2%.<sup id="cite_ref-UnsafeInjection2009_80-1" class="reference"><a href="#cite_note-UnsafeInjection2009-80"><span class="cite-bracket">&#91;</span>80<span class="cite-bracket">&#93;</span></a></sup> Risks are also associated with invasive procedures, assisted delivery, and dental care in this area of the world.<sup id="cite_ref-UnsafeInjection2009_80-2" class="reference"><a href="#cite_note-UnsafeInjection2009-80"><span class="cite-bracket">&#91;</span>80<span class="cite-bracket">&#93;</span></a></sup> </p><p>People giving or receiving <a href="/wiki/Tattoo" title="Tattoo">tattoos</a>, <a href="/wiki/Body_piercing" title="Body piercing">piercings</a>, and <a href="/wiki/Scarification" title="Scarification">scarification</a> are theoretically at risk of infection but no confirmed cases have been documented.<sup id="cite_ref-CDCBasics2012_81-0" class="reference"><a href="#cite_note-CDCBasics2012-81"><span class="cite-bracket">&#91;</span>81<span class="cite-bracket">&#93;</span></a></sup> It is not possible for <a href="/wiki/Mosquito" title="Mosquito">mosquitoes</a> or other insects to transmit HIV.<sup id="cite_ref-C4Wauto-8503951_82-0" class="reference"><a href="#cite_note-C4Wauto-8503951-82"><span class="cite-bracket">&#91;</span>82<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Mother-to-child">Mother-to-child</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main articles: <a href="/wiki/HIV_and_pregnancy" title="HIV and pregnancy">HIV and pregnancy</a> and <a href="/wiki/HIV_and_breastfeeding" class="mw-redirect" title="HIV and breastfeeding">HIV and breastfeeding</a></div> <p>HIV can be transmitted from mother to child during pregnancy, during delivery, or through breast milk, resulting in the baby also contracting HIV.<sup id="cite_ref-TransmissionM2007_18-8" class="reference"><a href="#cite_note-TransmissionM2007-18"><span class="cite-bracket">&#91;</span>18<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-83" class="reference"><a href="#cite_note-83"><span class="cite-bracket">&#91;</span>83<span class="cite-bracket">&#93;</span></a></sup> As of 2008, vertical transmission accounted for about 90% of cases of HIV in children.<sup id="cite_ref-Mother2010_84-0" class="reference"><a href="#cite_note-Mother2010-84"><span class="cite-bracket">&#91;</span>84<span class="cite-bracket">&#93;</span></a></sup> In the absence of treatment, the risk of transmission before or during birth is around 20%, and in those who also breastfeed 35%.<sup id="cite_ref-Mother2010_84-1" class="reference"><a href="#cite_note-Mother2010-84"><span class="cite-bracket">&#91;</span>84<span class="cite-bracket">&#93;</span></a></sup> Treatment decreases this risk to less than 5%.<sup id="cite_ref-85" class="reference"><a href="#cite_note-85"><span class="cite-bracket">&#91;</span>85<span class="cite-bracket">&#93;</span></a></sup> </p><p>Antiretrovirals when taken by either the mother or the baby decrease the risk of transmission in those who do breastfeed.<sup id="cite_ref-86" class="reference"><a href="#cite_note-86"><span class="cite-bracket">&#91;</span>86<span class="cite-bracket">&#93;</span></a></sup> If blood contaminates food during <a href="/wiki/Pre-chewing" class="mw-redirect" title="Pre-chewing">pre-chewing</a> it may pose a risk of transmission.<sup id="cite_ref-CDCBasics2012_81-1" class="reference"><a href="#cite_note-CDCBasics2012-81"><span class="cite-bracket">&#91;</span>81<span class="cite-bracket">&#93;</span></a></sup> If a woman is untreated, two years of breastfeeding results in an HIV/AIDS risk in her baby of about 17%.<sup id="cite_ref-WHO2011Breast_87-0" class="reference"><a href="#cite_note-WHO2011Breast-87"><span class="cite-bracket">&#91;</span>87<span class="cite-bracket">&#93;</span></a></sup> Due to the increased risk of death without breastfeeding in many areas in the developing world, the World Health Organization recommends either exclusive breastfeeding or the provision of safe formula.<sup id="cite_ref-WHO2011Breast_87-1" class="reference"><a href="#cite_note-WHO2011Breast-87"><span class="cite-bracket">&#91;</span>87<span class="cite-bracket">&#93;</span></a></sup> All women known to be HIV-positive should be taking lifelong antiretroviral therapy.<sup id="cite_ref-WHO2011Breast_87-2" class="reference"><a href="#cite_note-WHO2011Breast-87"><span class="cite-bracket">&#91;</span>87<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Virology">Virology</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/HIV" title="HIV">HIV</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HI-virion-structure_en.svg" class="mw-file-description"><img alt="diagram of microscopic viron structure" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/HI-virion-structure_en.svg/220px-HI-virion-structure_en.svg.png" decoding="async" width="220" height="169" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5e/HI-virion-structure_en.svg/330px-HI-virion-structure_en.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5e/HI-virion-structure_en.svg/440px-HI-virion-structure_en.svg.png 2x" data-file-width="512" data-file-height="393" /></a><figcaption>Diagram of an HIV virion structure</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HIV-budding-Color.jpg" class="mw-file-description"><img alt="A large round blue object with a smaller red object attached to it. Multiple small green spots are speckled over both." src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/HIV-budding-Color.jpg/220px-HIV-budding-Color.jpg" decoding="async" width="220" height="146" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/HIV-budding-Color.jpg/330px-HIV-budding-Color.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1a/HIV-budding-Color.jpg/440px-HIV-budding-Color.jpg 2x" data-file-width="2967" data-file-height="1971" /></a><figcaption><a href="/wiki/Scanning_electron_micrograph" class="mw-redirect" title="Scanning electron micrograph">Scanning electron micrograph</a> of HIV-1, colored green, budding from a cultured <a href="/wiki/Lymphocyte" title="Lymphocyte">lymphocyte</a></figcaption></figure> <p><a href="/wiki/HIV" title="HIV">HIV</a> is the cause of the spectrum of disease known as HIV/AIDS. HIV is a <a href="/wiki/Retrovirus" title="Retrovirus">retrovirus</a> that primarily infects components of the human <a href="/wiki/Immune_system" title="Immune system">immune system</a> such as CD4<sup>+</sup> T cells, <a href="/wiki/Macrophage" title="Macrophage">macrophages</a> and <a href="/wiki/Dendritic_cell" title="Dendritic cell">dendritic cells</a>. It directly and indirectly destroys CD4<sup>+</sup> T cells.<sup id="cite_ref-Alimonti_88-0" class="reference"><a href="#cite_note-Alimonti-88"><span class="cite-bracket">&#91;</span>88<span class="cite-bracket">&#93;</span></a></sup> </p><p>HIV is a member of the <a href="/wiki/Genus" title="Genus">genus</a> <i><a href="/wiki/Lentivirus" title="Lentivirus">Lentivirus</a></i>,<sup id="cite_ref-ICTV61.0.6_89-0" class="reference"><a href="#cite_note-ICTV61.0.6-89"><span class="cite-bracket">&#91;</span>89<span class="cite-bracket">&#93;</span></a></sup> part of the family <i><a href="/wiki/Retroviridae" class="mw-redirect" title="Retroviridae">Retroviridae</a></i>.<sup id="cite_ref-ICTV61._90-0" class="reference"><a href="#cite_note-ICTV61.-90"><span class="cite-bracket">&#91;</span>90<span class="cite-bracket">&#93;</span></a></sup> Lentiviruses share many <a href="/wiki/Morphology_(biology)" title="Morphology (biology)">morphological</a> and <a href="/wiki/Biology" title="Biology">biological</a> characteristics. Many species of mammals are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long <a href="/wiki/Incubation_period" title="Incubation period">incubation period</a>.<sup id="cite_ref-Levy_91-0" class="reference"><a href="#cite_note-Levy-91"><span class="cite-bracket">&#91;</span>91<span class="cite-bracket">&#93;</span></a></sup> Lentiviruses are transmitted as single-stranded, positive-<a href="/wiki/Sense_(molecular_biology)" title="Sense (molecular biology)">sense</a>, enveloped <a href="/wiki/RNA_virus" title="RNA virus">RNA viruses</a>. Upon entry into the target cell, the viral <a href="/wiki/RNA" title="RNA">RNA</a> <a href="/wiki/Genome" title="Genome">genome</a> is converted (reverse transcribed) into double-stranded <a href="/wiki/DNA" title="DNA">DNA</a> by a virally encoded <a href="/wiki/Reverse_transcriptase" title="Reverse transcriptase">reverse transcriptase</a> that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded <a href="/wiki/Integrase" title="Integrase">integrase</a> and host co-factors.<sup id="cite_ref-JASmith_92-0" class="reference"><a href="#cite_note-JASmith-92"><span class="cite-bracket">&#91;</span>92<span class="cite-bracket">&#93;</span></a></sup> Once integrated, the virus may become <a href="/wiki/Incubation_period" title="Incubation period">latent</a>, allowing the virus and its host cell to avoid detection by the immune system.<sup id="cite_ref-93" class="reference"><a href="#cite_note-93"><span class="cite-bracket">&#91;</span>93<span class="cite-bracket">&#93;</span></a></sup> Alternatively, the virus may be <a href="/wiki/Transcription_(genetics)" class="mw-redirect" title="Transcription (genetics)">transcribed</a>, producing new RNA genomes and viral proteins that are packaged and released from the cell as new virus particles that begin the replication cycle anew.<sup id="cite_ref-94" class="reference"><a href="#cite_note-94"><span class="cite-bracket">&#91;</span>94<span class="cite-bracket">&#93;</span></a></sup> </p><p>HIV is now known to spread between CD4<sup>+</sup> T cells by two parallel routes: cell-free spread and cell-to-cell spread, i.e. it employs hybrid spreading mechanisms.<sup id="cite_ref-Zhang_95-0" class="reference"><a href="#cite_note-Zhang-95"><span class="cite-bracket">&#91;</span>95<span class="cite-bracket">&#93;</span></a></sup> In the cell-free spread, virus particles bud from an infected T cell, enter the blood/extracellular fluid and then infect another T cell following a chance encounter.<sup id="cite_ref-Zhang_95-1" class="reference"><a href="#cite_note-Zhang-95"><span class="cite-bracket">&#91;</span>95<span class="cite-bracket">&#93;</span></a></sup> HIV can also disseminate by direct transmission from one cell to another by a process of cell-to-cell spread.<sup id="cite_ref-Jolly_96-0" class="reference"><a href="#cite_note-Jolly-96"><span class="cite-bracket">&#91;</span>96<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Sattentau_97-0" class="reference"><a href="#cite_note-Sattentau-97"><span class="cite-bracket">&#91;</span>97<span class="cite-bracket">&#93;</span></a></sup> The hybrid spreading mechanisms of HIV contribute to the virus' ongoing replication against antiretroviral therapies.<sup id="cite_ref-Zhang_95-2" class="reference"><a href="#cite_note-Zhang-95"><span class="cite-bracket">&#91;</span>95<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Sigal_98-0" class="reference"><a href="#cite_note-Sigal-98"><span class="cite-bracket">&#91;</span>98<span class="cite-bracket">&#93;</span></a></sup> </p><p>Two <a href="/wiki/Subtypes_of_HIV" title="Subtypes of HIV">types of HIV</a> have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was originally discovered (and initially referred to also as LAV or HTLV-III). It is more <a href="/wiki/Virulent" class="mw-redirect" title="Virulent">virulent</a>, more <a href="/wiki/Infectivity" title="Infectivity">infective</a>,<sup id="cite_ref-99" class="reference"><a href="#cite_note-99"><span class="cite-bracket">&#91;</span>99<span class="cite-bracket">&#93;</span></a></sup> and is the cause of the majority of HIV infections globally. The lower infectivity of HIV-2 as compared with HIV-1 implies that fewer people exposed to HIV-2 will be infected per exposure. Because of its relatively poor capacity for transmission, HIV-2 is largely confined to <a href="/wiki/West_Africa" title="West Africa">West Africa</a>.<sup id="cite_ref-Reeves_100-0" class="reference"><a href="#cite_note-Reeves-100"><span class="cite-bracket">&#91;</span>100<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pathophysiology">Pathophysiology</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Pathophysiology_of_HIV/AIDS" title="Pathophysiology of HIV/AIDS">Pathophysiology of HIV/AIDS</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><span><video id="mwe_player_0" poster="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/HIV_and_AIDS_explained_in_a_simple_way.webm/310px--HIV_and_AIDS_explained_in_a_simple_way.webm.jpg" controls="" preload="none" data-mw-tmh="" class="mw-file-element" width="310" height="174" data-durationhint="176" data-mwtitle="HIV_and_AIDS_explained_in_a_simple_way.webm" data-mwprovider="wikimediacommons" resource="/wiki/File:HIV_and_AIDS_explained_in_a_simple_way.webm"><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a1/HIV_and_AIDS_explained_in_a_simple_way.webm/HIV_and_AIDS_explained_in_a_simple_way.webm.480p.vp9.webm" type="video/webm; codecs=&quot;vp9, opus&quot;" data-transcodekey="480p.vp9.webm" data-width="854" data-height="480" /><source src="//upload.wikimedia.org/wikipedia/commons/a/a1/HIV_and_AIDS_explained_in_a_simple_way.webm" type="video/webm; codecs=&quot;vp8, vorbis&quot;" data-width="960" data-height="540" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a1/HIV_and_AIDS_explained_in_a_simple_way.webm/HIV_and_AIDS_explained_in_a_simple_way.webm.144p.mjpeg.mov" type="video/quicktime" data-transcodekey="144p.mjpeg.mov" data-width="256" data-height="144" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a1/HIV_and_AIDS_explained_in_a_simple_way.webm/HIV_and_AIDS_explained_in_a_simple_way.webm.240p.vp9.webm" type="video/webm; codecs=&quot;vp9, opus&quot;" data-transcodekey="240p.vp9.webm" data-width="426" data-height="240" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a1/HIV_and_AIDS_explained_in_a_simple_way.webm/HIV_and_AIDS_explained_in_a_simple_way.webm.360p.vp9.webm" type="video/webm; codecs=&quot;vp9, opus&quot;" data-transcodekey="360p.vp9.webm" data-width="640" data-height="360" /><source src="//upload.wikimedia.org/wikipedia/commons/transcoded/a/a1/HIV_and_AIDS_explained_in_a_simple_way.webm/HIV_and_AIDS_explained_in_a_simple_way.webm.360p.webm" type="video/webm; codecs=&quot;vp8, vorbis&quot;" data-transcodekey="360p.webm" data-width="640" data-height="360" /><track src="https://commons.wikimedia.org/w/api.php?action=timedtext&amp;title=File%3AHIV_and_AIDS_explained_in_a_simple_way.webm&amp;lang=en&amp;trackformat=vtt&amp;origin=%2A" kind="subtitles" type="text/vtt" srclang="en" label="English ‪(en)‬" data-dir="ltr" /><track src="https://commons.wikimedia.org/w/api.php?action=timedtext&amp;title=File%3AHIV_and_AIDS_explained_in_a_simple_way.webm&amp;lang=fr&amp;trackformat=vtt&amp;origin=%2A" kind="subtitles" type="text/vtt" srclang="fr" label="français ‪(fr)‬" data-dir="ltr" /><track src="https://commons.wikimedia.org/w/api.php?action=timedtext&amp;title=File%3AHIV_and_AIDS_explained_in_a_simple_way.webm&amp;lang=kk&amp;trackformat=vtt&amp;origin=%2A" kind="subtitles" type="text/vtt" srclang="kk" label="қазақша ‪(kk)‬" data-dir="ltr" /><track src="https://commons.wikimedia.org/w/api.php?action=timedtext&amp;title=File%3AHIV_and_AIDS_explained_in_a_simple_way.webm&amp;lang=vi&amp;trackformat=vtt&amp;origin=%2A" kind="subtitles" type="text/vtt" srclang="vi" label="Tiếng Việt ‪(vi)‬" data-dir="ltr" /></video></span><figcaption>HIV/AIDS explained in a simple way</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Hiv_replication_cycle.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Hiv_replication_cycle.gif/310px-Hiv_replication_cycle.gif" decoding="async" width="310" height="236" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Hiv_replication_cycle.gif/465px-Hiv_replication_cycle.gif 1.5x, //upload.wikimedia.org/wikipedia/commons/9/99/Hiv_replication_cycle.gif 2x" data-file-width="545" data-file-height="415" /></a><figcaption>HIV replication cycle</figcaption></figure> <p>After the virus enters the body, there is a period of rapid <a href="/wiki/Viral_replication" title="Viral replication">viral replication</a>, leading to an abundance of virus in the peripheral blood. During primary infection, the level of HIV may reach several million virus particles per milliliter of blood.<sup id="cite_ref-Piatak_101-0" class="reference"><a href="#cite_note-Piatak-101"><span class="cite-bracket">&#91;</span>101<span class="cite-bracket">&#93;</span></a></sup> This response is accompanied by a marked drop in the number of circulating <a href="/wiki/T_helper_cell" title="T helper cell">CD4<sup>+</sup> T cells</a>. The acute <a href="/wiki/Viremia" title="Viremia">viremia</a> is almost invariably associated with activation of <a href="/wiki/Cytotoxic_T_cell" title="Cytotoxic T cell">CD8<sup>+</sup> T cells</a>, which kill HIV-infected cells, and subsequently with antibody production, or <a href="/wiki/Seroconversion" title="Seroconversion">seroconversion</a>. The CD8<sup>+</sup> T cell response is thought to be important in controlling virus levels, which peak and then decline, as the CD4<sup>+</sup> T cell counts recover. A good CD8<sup>+</sup> T cell response has been linked to slower disease progression and a better prognosis, though it does not eliminate the virus.<sup id="cite_ref-Pantaleo1998_102-0" class="reference"><a href="#cite_note-Pantaleo1998-102"><span class="cite-bracket">&#91;</span>102<span class="cite-bracket">&#93;</span></a></sup> </p><p>Ultimately, HIV causes AIDS by depleting CD4<sup>+</sup> T cells. This weakens the immune system and allows <a href="/wiki/Opportunistic_infection" title="Opportunistic infection">opportunistic infections</a>. T cells are essential to the immune response and without them, the body cannot fight infections or kill cancerous cells. The mechanism of CD4<sup>+</sup> T cell depletion differs in the acute and chronic phases.<sup id="cite_ref-pmid16679064_103-0" class="reference"><a href="#cite_note-pmid16679064-103"><span class="cite-bracket">&#91;</span>103<span class="cite-bracket">&#93;</span></a></sup> During the acute phase, HIV-induced cell lysis and killing of infected cells by CD8<sup>+</sup> T cells accounts for CD4<sup>+</sup> T cell depletion, although <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a> may also be a factor. During the chronic phase, the consequences of generalized immune activation coupled with the gradual loss of the ability of the immune system to generate new T cells appear to account for the slow decline in CD4<sup>+</sup> T cell numbers.<sup id="cite_ref-104" class="reference"><a href="#cite_note-104"><span class="cite-bracket">&#91;</span>104<span class="cite-bracket">&#93;</span></a></sup> </p><p>Although the symptoms of immune deficiency characteristic of AIDS do not appear for years after a person is infected, the bulk of CD4<sup>+</sup> T cell loss occurs during the first weeks of infection, especially in the intestinal mucosa, which harbors the majority of the lymphocytes found in the body.<sup id="cite_ref-pmid15365095_105-0" class="reference"><a href="#cite_note-pmid15365095-105"><span class="cite-bracket">&#91;</span>105<span class="cite-bracket">&#93;</span></a></sup> The reason for the preferential loss of mucosal CD4<sup>+</sup> T cells is that the majority of mucosal CD4<sup>+</sup> T cells express the <a href="/wiki/CCR5" title="CCR5">CCR5</a> protein which HIV uses as a <a href="/wiki/Co-receptor" title="Co-receptor">co-receptor</a> to gain access to the cells, whereas only a small fraction of CD4<sup>+</sup> T cells in the bloodstream do so.<sup id="cite_ref-pmid15365096_106-0" class="reference"><a href="#cite_note-pmid15365096-106"><span class="cite-bracket">&#91;</span>106<span class="cite-bracket">&#93;</span></a></sup> A <a href="/wiki/CCR5-%CE%9432" class="mw-redirect" title="CCR5-Δ32">specific genetic change</a> that alters the CCR5 protein when present in both <a href="/wiki/Chromosome" title="Chromosome">chromosomes</a> very effectively prevents HIV-1 infection.<sup id="cite_ref-107" class="reference"><a href="#cite_note-107"><span class="cite-bracket">&#91;</span>107<span class="cite-bracket">&#93;</span></a></sup> </p><p>HIV seeks out and destroys CCR5 expressing CD4<sup>+</sup> T cells during acute infection.<sup id="cite_ref-Julio2011_108-0" class="reference"><a href="#cite_note-Julio2011-108"><span class="cite-bracket">&#91;</span>108<span class="cite-bracket">&#93;</span></a></sup> A vigorous immune response eventually controls the infection and initiates the clinically latent phase. CD4<sup>+</sup> T cells in mucosal tissues remain particularly affected.<sup id="cite_ref-Julio2011_108-1" class="reference"><a href="#cite_note-Julio2011-108"><span class="cite-bracket">&#91;</span>108<span class="cite-bracket">&#93;</span></a></sup> Continuous HIV replication causes a state of generalized immune activation persisting throughout the chronic phase.<sup id="cite_ref-pmid18161758_109-0" class="reference"><a href="#cite_note-pmid18161758-109"><span class="cite-bracket">&#91;</span>109<span class="cite-bracket">&#93;</span></a></sup> Immune activation, which is reflected by the increased activation state of immune cells and release of pro-inflammatory <a href="/wiki/Cytokine" title="Cytokine">cytokines</a>, results from the activity of several HIV <a href="/wiki/Gene_product" title="Gene product">gene products</a> and the immune response to ongoing HIV replication. It is also linked to the breakdown of the immune surveillance system of the gastrointestinal mucosal barrier caused by the depletion of mucosal CD4<sup>+</sup> T cells during the acute phase of disease.<sup id="cite_ref-pmid17115046_110-0" class="reference"><a href="#cite_note-pmid17115046-110"><span class="cite-bracket">&#91;</span>110<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Diagnosis_of_HIV/AIDS" title="Diagnosis of HIV/AIDS">Diagnosis of HIV/AIDS</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Hiv-timecourse_copy.svg" class="mw-file-description"><img alt="A graph with two lines. One in blue moves from high on the right to low on the left with a brief rise in the middle. The second line in red moves from zero to very high then drops to low and gradually rises to high again" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Hiv-timecourse_copy.svg/220px-Hiv-timecourse_copy.svg.png" decoding="async" width="220" height="131" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Hiv-timecourse_copy.svg/330px-Hiv-timecourse_copy.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Hiv-timecourse_copy.svg/440px-Hiv-timecourse_copy.svg.png 2x" data-file-width="729" data-file-height="433" /></a><figcaption>A generalized graph of the relationship between HIV copies (viral load) and CD4<sup>+</sup> T cell counts over the average course of untreated HIV infection: <style data-mw-deduplicate="TemplateStyles:r981673959">.mw-parser-output .legend{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .legend-color{display:inline-block;min-width:1.25em;height:1.25em;line-height:1.25;margin:1px 0;text-align:center;border:1px solid black;background-color:transparent;color:black}.mw-parser-output .legend-text{}</style><div class="legend"><span class="legend-line mw-no-invert" style="display: inline-block; vertical-align: middle; width: 1.67em; height: 0; border-style: none; border-top: 2px dotted black;border-top:blue solid 2px;">&#160;</span>&#160;CD4<sup>+</sup> T Lymphocyte count (cells/mm<sup>3</sup>)</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-line mw-no-invert" style="display: inline-block; vertical-align: middle; width: 1.67em; height: 0; border-style: none; border-top: 2px dotted black;border-top:red solid 2px;">&#160;</span>&#160;HIV RNA copies per mL of plasma</div></figcaption></figure> <table class="wikitable floatright"> <caption>Days after exposure needed for the test to be accurate<sup id="cite_ref-111" class="reference"><a href="#cite_note-111"><span class="cite-bracket">&#91;</span>111<span class="cite-bracket">&#93;</span></a></sup> </caption> <tbody><tr> <th>Blood test </th> <th>Days </th></tr> <tr> <td>Antibody test <small>(rapid test, <a href="/wiki/ELISA" title="ELISA">ELISA</a> 3rd gen)</small> </td> <td>23–90 </td></tr> <tr> <td>Antibody and p24 antigen test <small>(ELISA 4th gen)</small> </td> <td>18–45 </td></tr> <tr> <td>PCR </td> <td>10–33 </td></tr></tbody></table> <p>HIV/AIDS is diagnosed via laboratory testing and then staged based on the presence of <a href="/wiki/AIDS_defining_clinical_condition" class="mw-redirect" title="AIDS defining clinical condition">certain signs or symptoms</a>.<sup id="cite_ref-WHOCase2007_30-3" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> HIV screening is recommended by the <a href="/wiki/United_States_Preventive_Services_Task_Force" title="United States Preventive Services Task Force">United States Preventive Services Task Force</a> for all people 15&#160;years to 65&#160;years of age, including all pregnant women.<sup id="cite_ref-USP2019Screen_112-0" class="reference"><a href="#cite_note-USP2019Screen-112"><span class="cite-bracket">&#91;</span>112<span class="cite-bracket">&#93;</span></a></sup> Additionally, testing is recommended for those at high risk, which includes anyone diagnosed with a sexually transmitted illness.<sup id="cite_ref-Deut2010_33-2" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-USP2019Screen_112-1" class="reference"><a href="#cite_note-USP2019Screen-112"><span class="cite-bracket">&#91;</span>112<span class="cite-bracket">&#93;</span></a></sup> In many areas of the world, a third of HIV carriers only discover they are infected at an advanced stage of the disease when AIDS or severe immunodeficiency has become apparent.<sup id="cite_ref-Deut2010_33-3" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="HIV_testing">HIV testing</h3></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HIV_Rapid_Test_being_administered.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/76/HIV_Rapid_Test_being_administered.jpg/220px-HIV_Rapid_Test_being_administered.jpg" decoding="async" width="220" height="293" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/76/HIV_Rapid_Test_being_administered.jpg/330px-HIV_Rapid_Test_being_administered.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/76/HIV_Rapid_Test_being_administered.jpg/440px-HIV_Rapid_Test_being_administered.jpg 2x" data-file-width="2448" data-file-height="3264" /></a><figcaption>HIV rapid test being administered</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Oraquick.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Oraquick.jpg/220px-Oraquick.jpg" decoding="async" width="220" height="281" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Oraquick.jpg/330px-Oraquick.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Oraquick.jpg/440px-Oraquick.jpg 2x" data-file-width="1638" data-file-height="2091" /></a><figcaption>Oraquick HIV test</figcaption></figure> <p>Most people infected with HIV develop <a href="/wiki/Seroconvert" class="mw-redirect" title="Seroconvert">seroconverted</a> (antigen-specific) <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> within three to twelve weeks after the initial infection.<sup id="cite_ref-M118_32-12" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> Diagnosis of primary HIV before seroconversion is done by measuring HIV-<a href="/wiki/RNA" title="RNA">RNA</a> or <a href="/wiki/Diagnosis_of_HIV/AIDS#Antigen_tests" title="Diagnosis of HIV/AIDS">p24 antigen</a>.<sup id="cite_ref-M118_32-13" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> Positive results obtained by antibody or <a href="/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction">PCR</a> testing are confirmed either by a different antibody or by PCR.<sup id="cite_ref-WHOCase2007_30-4" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> </p><p>Antibody tests in children younger than 18&#160;months are typically inaccurate, due to the continued presence of <a href="/wiki/Maternal_Passive_Immunity#Naturally_acquired_passive_immunity" class="mw-redirect" title="Maternal Passive Immunity">maternal antibodies</a>.<sup id="cite_ref-ChildDiag2010_113-0" class="reference"><a href="#cite_note-ChildDiag2010-113"><span class="cite-bracket">&#91;</span>113<span class="cite-bracket">&#93;</span></a></sup> Thus HIV infection can only be diagnosed by PCR testing for HIV RNA or DNA, or via testing for the p24 antigen.<sup id="cite_ref-WHOCase2007_30-5" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> Much of the world lacks access to reliable PCR testing, and people in many places simply wait until either symptoms develop or the child is old enough for accurate antibody testing.<sup id="cite_ref-ChildDiag2010_113-1" class="reference"><a href="#cite_note-ChildDiag2010-113"><span class="cite-bracket">&#91;</span>113<span class="cite-bracket">&#93;</span></a></sup> In sub-Saharan Africa between 2007 and 2009, between 30% and 70% of the population were aware of their HIV status.<sup id="cite_ref-UN2011Eighty_114-0" class="reference"><a href="#cite_note-UN2011Eighty-114"><span class="cite-bracket">&#91;</span>114<span class="cite-bracket">&#93;</span></a></sup> In 2009, between 3.6% and 42% of men and women in sub-Saharan countries were tested;<sup id="cite_ref-UN2011Eighty_114-1" class="reference"><a href="#cite_note-UN2011Eighty-114"><span class="cite-bracket">&#91;</span>114<span class="cite-bracket">&#93;</span></a></sup> this represented a significant increase compared to previous years.<sup id="cite_ref-UN2011Eighty_114-2" class="reference"><a href="#cite_note-UN2011Eighty-114"><span class="cite-bracket">&#91;</span>114<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Classifications">Classifications</h3></div> <p>Two main clinical staging systems are used to classify HIV and HIV-related disease for <a href="/wiki/Disease_surveillance" title="Disease surveillance">surveillance</a> purposes: the <a href="/wiki/WHO_disease_staging_system_for_HIV_infection_and_disease" title="WHO disease staging system for HIV infection and disease">WHO disease staging system for HIV infection and disease</a>,<sup id="cite_ref-WHOCase2007_30-6" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> and the <a href="/wiki/CDC_classification_system_for_HIV_infection" title="CDC classification system for HIV infection">CDC classification system for HIV infection</a>.<sup id="cite_ref-CDCCase2008_115-0" class="reference"><a href="#cite_note-CDCCase2008-115"><span class="cite-bracket">&#91;</span>115<span class="cite-bracket">&#93;</span></a></sup> The CDC's classification system is more frequently adopted in developed countries. Since the WHO's staging system does not require laboratory tests, it is suited to the resource-restricted conditions encountered in developing countries, where it can also be used to help guide clinical management. Despite their differences, the two systems allow a comparison for statistical purposes.<sup id="cite_ref-M121_29-3" class="reference"><a href="#cite_note-M121-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-WHOCase2007_30-7" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-CDCCase2008_115-1" class="reference"><a href="#cite_note-CDCCase2008-115"><span class="cite-bracket">&#91;</span>115<span class="cite-bracket">&#93;</span></a></sup> </p><p>The World Health Organization first proposed a definition for AIDS in 1986.<sup id="cite_ref-WHOCase2007_30-8" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> Since then, the WHO classification has been updated and expanded several times, with the most recent version being published in 2007.<sup id="cite_ref-WHOCase2007_30-9" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> The WHO system uses the following categories: </p> <ul><li>Primary HIV infection: May be either asymptomatic or associated with acute retroviral syndrome<sup id="cite_ref-WHOCase2007_30-10" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup></li> <li>Stage I: HIV infection is <a href="/wiki/Asymptomatic" title="Asymptomatic">asymptomatic</a> with a CD4<sup>+</sup> T cell count (also known as CD4 count) greater than 500 per microlitre (μL or cubic mm) of blood.<sup id="cite_ref-WHOCase2007_30-11" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup> May include generalized lymph node enlargement.<sup id="cite_ref-WHOCase2007_30-12" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup></li> <li>Stage II: Mild symptoms, which may include minor <a href="/wiki/Mucous_membrane" title="Mucous membrane">mucocutaneous</a> manifestations and recurrent <a href="/wiki/Upper_respiratory_tract_infection" title="Upper respiratory tract infection">upper respiratory tract infections</a>. A CD4 count of less than 500/μL<sup id="cite_ref-WHOCase2007_30-13" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup></li> <li>Stage III: Advanced symptoms, which may include unexplained <a href="/wiki/Chronic_(medical)" class="mw-redirect" title="Chronic (medical)">chronic</a> diarrhea for longer than a month, severe bacterial infections including tuberculosis of the lung, and a CD4 count of less than 350/μL<sup id="cite_ref-WHOCase2007_30-14" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup></li> <li>Stage IV or AIDS: severe symptoms, which include <a href="/wiki/Toxoplasmosis" title="Toxoplasmosis">toxoplasmosis</a> of the brain, <a href="/wiki/Candidiasis" title="Candidiasis">candidiasis</a> of the <a href="/wiki/Esophagus" title="Esophagus">esophagus</a>, <a href="/wiki/Trachea" title="Trachea">trachea</a>, <a href="/wiki/Bronchi" class="mw-redirect" title="Bronchi">bronchi</a>, or <a href="/wiki/Lung" title="Lung">lungs</a>, and <a href="/wiki/Kaposi%27s_sarcoma" title="Kaposi&#39;s sarcoma">Kaposi's sarcoma</a>. A CD4 count of less than 200/μL<sup id="cite_ref-WHOCase2007_30-15" class="reference"><a href="#cite_note-WHOCase2007-30"><span class="cite-bracket">&#91;</span>30<span class="cite-bracket">&#93;</span></a></sup></li></ul> <p>The U.S. Centers for Disease Control and Prevention also created a classification system for HIV, and updated it in 2008 and 2014.<sup id="cite_ref-CDCCase2008_115-2" class="reference"><a href="#cite_note-CDCCase2008-115"><span class="cite-bracket">&#91;</span>115<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-CDC2014Clas_116-0" class="reference"><a href="#cite_note-CDC2014Clas-116"><span class="cite-bracket">&#91;</span>116<span class="cite-bracket">&#93;</span></a></sup> This system classifies HIV infections based on CD4 count and clinical symptoms, and describes the infection in five groups.<sup id="cite_ref-CDC2014Clas_116-1" class="reference"><a href="#cite_note-CDC2014Clas-116"><span class="cite-bracket">&#91;</span>116<span class="cite-bracket">&#93;</span></a></sup> In those greater than six years of age it is:<sup id="cite_ref-CDC2014Clas_116-2" class="reference"><a href="#cite_note-CDC2014Clas-116"><span class="cite-bracket">&#91;</span>116<span class="cite-bracket">&#93;</span></a></sup> </p> <ul><li>Stage 0: the time between a negative or indeterminate HIV test followed less than 180 days by a positive test</li> <li>Stage 1: CD4 count ≥ 500&#160;cells/μL and no AIDS-defining conditions</li> <li>Stage 2: CD4 count 200 to 500&#160;cells/μL and no AIDS-defining conditions</li> <li>Stage 3: CD4 count ≤ 200&#160;cells/μL or AIDS-defining conditions</li> <li>Unknown: if insufficient information is available to make any of the above classifications.</li></ul> <p>For surveillance purposes, the AIDS diagnosis still stands even if, after treatment, the CD4<sup>+</sup> T cell count rises to above 200 per μL of blood or other AIDS-defining illnesses are cured.<sup id="cite_ref-M121_29-4" class="reference"><a href="#cite_note-M121-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Prevention">Prevention</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Prevention_of_HIV/AIDS" title="Prevention of HIV/AIDS">Prevention of HIV/AIDS</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:AIDS_Clinic,_McLeod_Ganj,_2010.jpg" class="mw-file-description"><img alt="A run down a two-story building with several signs related to AIDS prevention" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b0/AIDS_Clinic%2C_McLeod_Ganj%2C_2010.jpg/220px-AIDS_Clinic%2C_McLeod_Ganj%2C_2010.jpg" decoding="async" width="220" height="269" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b0/AIDS_Clinic%2C_McLeod_Ganj%2C_2010.jpg/330px-AIDS_Clinic%2C_McLeod_Ganj%2C_2010.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b0/AIDS_Clinic%2C_McLeod_Ganj%2C_2010.jpg/440px-AIDS_Clinic%2C_McLeod_Ganj%2C_2010.jpg 2x" data-file-width="768" data-file-height="940" /></a><figcaption>AIDS clinic, <a href="/wiki/McLeod_Ganj" title="McLeod Ganj">McLeod Ganj</a>, Himachal Pradesh, India, 2010</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Sexual_contact">Sexual contact</h3></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:FACING_AIDS_a_condom_and_a_pill_at_a_time_-_I_am_FACING_AIDS_because_people_I_-3_are_infected._(5202985364).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/FACING_AIDS_a_condom_and_a_pill_at_a_time_-_I_am_FACING_AIDS_because_people_I_-3_are_infected._%285202985364%29.jpg/220px-FACING_AIDS_a_condom_and_a_pill_at_a_time_-_I_am_FACING_AIDS_because_people_I_-3_are_infected._%285202985364%29.jpg" decoding="async" width="220" height="162" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/FACING_AIDS_a_condom_and_a_pill_at_a_time_-_I_am_FACING_AIDS_because_people_I_-3_are_infected._%285202985364%29.jpg/330px-FACING_AIDS_a_condom_and_a_pill_at_a_time_-_I_am_FACING_AIDS_because_people_I_-3_are_infected._%285202985364%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b6/FACING_AIDS_a_condom_and_a_pill_at_a_time_-_I_am_FACING_AIDS_because_people_I_-3_are_infected._%285202985364%29.jpg/440px-FACING_AIDS_a_condom_and_a_pill_at_a_time_-_I_am_FACING_AIDS_because_people_I_-3_are_infected._%285202985364%29.jpg 2x" data-file-width="1161" data-file-height="855" /></a><figcaption>People wearing AIDS awareness signs. On the left: "Facing AIDS a condom and a pill at a time"; on the right: "I am Facing AIDS because people I ♥ are infected"</figcaption></figure> <p>Consistent <a href="/wiki/Condom" title="Condom">condom</a> use reduces the risk of HIV transmission by approximately 80% over the long term.<sup id="cite_ref-117" class="reference"><a href="#cite_note-117"><span class="cite-bracket">&#91;</span>117<span class="cite-bracket">&#93;</span></a></sup> When condoms are used consistently by a couple in which one person is infected, the rate of HIV infection is less than 1% per year.<sup id="cite_ref-WHOCondoms_118-0" class="reference"><a href="#cite_note-WHOCondoms-118"><span class="cite-bracket">&#91;</span>118<span class="cite-bracket">&#93;</span></a></sup> There is some evidence to suggest that <a href="/wiki/Female_condom" title="Female condom">female condoms</a> may provide an equivalent level of protection.<sup id="cite_ref-119" class="reference"><a href="#cite_note-119"><span class="cite-bracket">&#91;</span>119<span class="cite-bracket">&#93;</span></a></sup> Application of a vaginal gel containing <a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">tenofovir</a> (a <a href="/wiki/Reverse_transcriptase_inhibitor" class="mw-redirect" title="Reverse transcriptase inhibitor">reverse transcriptase inhibitor</a>) immediately before sex seems to reduce infection rates by approximately 40% among African women.<sup id="cite_ref-VagGel2012_120-0" class="reference"><a href="#cite_note-VagGel2012-120"><span class="cite-bracket">&#91;</span>120<span class="cite-bracket">&#93;</span></a></sup> By contrast, use of the <a href="/wiki/Spermicide" title="Spermicide">spermicide</a> <a href="/wiki/Nonoxynol-9" title="Nonoxynol-9">nonoxynol-9</a> may increase the risk of transmission due to its tendency to cause vaginal and rectal irritation.<sup id="cite_ref-121" class="reference"><a href="#cite_note-121"><span class="cite-bracket">&#91;</span>121<span class="cite-bracket">&#93;</span></a></sup> </p><p><a href="/wiki/Circumcision" title="Circumcision">Circumcision</a> in <a href="/wiki/Sub-Saharan_Africa" title="Sub-Saharan Africa">sub-Saharan Africa</a> "reduces the acquisition of HIV by heterosexual men by between 38% and 66% over 24 months".<sup id="cite_ref-122" class="reference"><a href="#cite_note-122"><span class="cite-bracket">&#91;</span>122<span class="cite-bracket">&#93;</span></a></sup> Owing to these studies, both the World Health Organization and <a href="/wiki/UNAIDS" class="mw-redirect" title="UNAIDS">UNAIDS</a> recommended male circumcision in 2007 as a method of preventing female-to-male HIV transmission in areas with high rates of HIV.<sup id="cite_ref-123" class="reference"><a href="#cite_note-123"><span class="cite-bracket">&#91;</span>123<span class="cite-bracket">&#93;</span></a></sup> However, whether it protects against male-to-female transmission is disputed,<sup id="cite_ref-124" class="reference"><a href="#cite_note-124"><span class="cite-bracket">&#91;</span>124<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-pmid19849961_125-0" class="reference"><a href="#cite_note-pmid19849961-125"><span class="cite-bracket">&#91;</span>125<span class="cite-bracket">&#93;</span></a></sup> and whether it is of benefit in <a href="/wiki/Developed_countries" class="mw-redirect" title="Developed countries">developed countries</a> and among <a href="/wiki/Men_who_have_sex_with_men" title="Men who have sex with men">men who have sex with men</a> is undetermined.<sup id="cite_ref-126" class="reference"><a href="#cite_note-126"><span class="cite-bracket">&#91;</span>126<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-127" class="reference"><a href="#cite_note-127"><span class="cite-bracket">&#91;</span>127<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-128" class="reference"><a href="#cite_note-128"><span class="cite-bracket">&#91;</span>128<span class="cite-bracket">&#93;</span></a></sup> </p><p>Programs encouraging <a href="/wiki/Abstinence-only_sex_education" title="Abstinence-only sex education">sexual abstinence</a> do not appear to affect subsequent HIV risk.<sup id="cite_ref-129" class="reference"><a href="#cite_note-129"><span class="cite-bracket">&#91;</span>129<span class="cite-bracket">&#93;</span></a></sup> Evidence of any benefit from <a href="/wiki/Peer_education" title="Peer education">peer education</a> is equally poor.<sup id="cite_ref-pmid22641791_130-0" class="reference"><a href="#cite_note-pmid22641791-130"><span class="cite-bracket">&#91;</span>130<span class="cite-bracket">&#93;</span></a></sup> Comprehensive <a href="/wiki/Sex_education" title="Sex education">sexual education</a> provided at school may decrease high-risk behavior.<sup id="cite_ref-131" class="reference"><a href="#cite_note-131"><span class="cite-bracket">&#91;</span>131<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-132" class="reference"><a href="#cite_note-132"><span class="cite-bracket">&#91;</span>132<span class="cite-bracket">&#93;</span></a></sup> A substantial minority of young people continues to engage in high-risk practices despite knowing about HIV/AIDS, underestimating their own risk of becoming infected with HIV.<sup id="cite_ref-Patel2008_133-0" class="reference"><a href="#cite_note-Patel2008-133"><span class="cite-bracket">&#91;</span>133<span class="cite-bracket">&#93;</span></a></sup> Voluntary counseling and testing people for HIV does not affect risky behavior in those who test negative but does increase condom use in those who test positive.<sup id="cite_ref-134" class="reference"><a href="#cite_note-134"><span class="cite-bracket">&#91;</span>134<span class="cite-bracket">&#93;</span></a></sup> Enhanced family planning services appear to increase the likelihood of women with HIV using contraception, compared to basic services.<sup id="cite_ref-135" class="reference"><a href="#cite_note-135"><span class="cite-bracket">&#91;</span>135<span class="cite-bracket">&#93;</span></a></sup> It is not known whether treating other sexually transmitted infections is effective in preventing HIV.<sup id="cite_ref-CochraneSTI2012_66-1" class="reference"><a href="#cite_note-CochraneSTI2012-66"><span class="cite-bracket">&#91;</span>66<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pre-exposure">Pre-exposure</h3></div> <p>Antiretroviral treatment among people with HIV whose CD4 count ≤ 550 cells/μL is a very effective way to prevent HIV infection of their partner (a strategy known as treatment as prevention, or TASP).<sup id="cite_ref-Anglemyer2013_136-0" class="reference"><a href="#cite_note-Anglemyer2013-136"><span class="cite-bracket">&#91;</span>136<span class="cite-bracket">&#93;</span></a></sup> TASP is associated with a 10- to 20-fold reduction in transmission risk.<sup id="cite_ref-Anglemyer2013_136-1" class="reference"><a href="#cite_note-Anglemyer2013-136"><span class="cite-bracket">&#91;</span>136<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Chou2012_137-0" class="reference"><a href="#cite_note-Chou2012-137"><span class="cite-bracket">&#91;</span>137<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Pre-exposure_prophylaxis" title="Pre-exposure prophylaxis">Pre-exposure prophylaxis</a> for HIV ("<a href="/wiki/Pre-exposure_prophylaxis_for_HIV_prevention" title="Pre-exposure prophylaxis for HIV prevention">PrEP</a>") with a daily dose of the medications <a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">tenofovir</a>, with or without <a href="/wiki/Emtricitabine" title="Emtricitabine">emtricitabine</a>, is effective in people at high risk including men who have sex with men, couples where one is HIV-positive, and young heterosexuals in Africa.<sup id="cite_ref-VagGel2012_120-1" class="reference"><a href="#cite_note-VagGel2012-120"><span class="cite-bracket">&#91;</span>120<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-138" class="reference"><a href="#cite_note-138"><span class="cite-bracket">&#91;</span>138<span class="cite-bracket">&#93;</span></a></sup> It may also be effective in intravenous drug users, with a study finding a decrease in risk of 0.7 to 0.4 per 100&#160;person&#160;years.<sup id="cite_ref-139" class="reference"><a href="#cite_note-139"><span class="cite-bracket">&#91;</span>139<span class="cite-bracket">&#93;</span></a></sup> The <a href="/wiki/USPSTF" class="mw-redirect" title="USPSTF">USPSTF</a>, in 2019, recommended PrEP in those who are at high risk.<sup id="cite_ref-140" class="reference"><a href="#cite_note-140"><span class="cite-bracket">&#91;</span>140<span class="cite-bracket">&#93;</span></a></sup> </p><p><a href="/wiki/Universal_precautions" title="Universal precautions">Universal precautions</a> within the health care environment are believed to be effective in decreasing the risk of HIV.<sup id="cite_ref-141" class="reference"><a href="#cite_note-141"><span class="cite-bracket">&#91;</span>141<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Intravenous_drug_use" class="mw-redirect" title="Intravenous drug use">Intravenous drug use</a> is an important risk factor, and <a href="/wiki/Harm_reduction" title="Harm reduction">harm reduction</a> strategies such as <a href="/wiki/Needle-exchange_program" class="mw-redirect" title="Needle-exchange program">needle-exchange programs</a> and <a href="/wiki/Opioid_replacement_therapy" class="mw-redirect" title="Opioid replacement therapy">opioid substitution therapy</a> appear effective in decreasing this risk.<sup id="cite_ref-Kurth2011_142-0" class="reference"><a href="#cite_note-Kurth2011-142"><span class="cite-bracket">&#91;</span>142<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-143" class="reference"><a href="#cite_note-143"><span class="cite-bracket">&#91;</span>143<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Post-exposure">Post-exposure</h3></div> <p>A course of antiretrovirals administered within 48 to 72&#160;hours after exposure to HIV-positive blood or genital secretions is referred to as <a href="/wiki/Post-exposure_prophylaxis" title="Post-exposure prophylaxis">post-exposure prophylaxis</a> (PEP).<sup id="cite_ref-Prevention2012_144-0" class="reference"><a href="#cite_note-Prevention2012-144"><span class="cite-bracket">&#91;</span>144<span class="cite-bracket">&#93;</span></a></sup> The use of the single agent <a href="/wiki/Zidovudine" title="Zidovudine">zidovudine</a> reduces the risk of an HIV infection five-fold following a needle-stick injury.<sup id="cite_ref-Prevention2012_144-1" class="reference"><a href="#cite_note-Prevention2012-144"><span class="cite-bracket">&#91;</span>144<span class="cite-bracket">&#93;</span></a></sup> As of 2013<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=HIV/AIDS&amp;action=edit">&#91;update&#93;</a></sup>, the prevention regimen recommended in the United States consists of three medications—<a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">tenofovir</a>, <a href="/wiki/Emtricitabine" title="Emtricitabine">emtricitabine</a> and <a href="/wiki/Raltegravir" title="Raltegravir">raltegravir</a>—as this may reduce the risk further.<sup id="cite_ref-145" class="reference"><a href="#cite_note-145"><span class="cite-bracket">&#91;</span>145<span class="cite-bracket">&#93;</span></a></sup> </p><p>PEP treatment is recommended after a <a href="/wiki/Sexual_assault" title="Sexual assault">sexual assault</a> when the perpetrator is known to be HIV-positive, but is controversial when their HIV status is unknown.<sup id="cite_ref-NEJM2011Sex_146-0" class="reference"><a href="#cite_note-NEJM2011Sex-146"><span class="cite-bracket">&#91;</span>146<span class="cite-bracket">&#93;</span></a></sup> The duration of treatment is usually four weeks<sup id="cite_ref-CochranePEP2007_147-0" class="reference"><a href="#cite_note-CochranePEP2007-147"><span class="cite-bracket">&#91;</span>147<span class="cite-bracket">&#93;</span></a></sup> and is frequently associated with adverse effects—where zidovudine is used, about 70% of cases result in adverse effects such as nausea (24%), fatigue (22%), emotional distress (13%) and headaches (9%).<sup id="cite_ref-AFP2007k_54-2" class="reference"><a href="#cite_note-AFP2007k-54"><span class="cite-bracket">&#91;</span>54<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Mother-to-child_2">Mother-to-child</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/HIV_and_pregnancy" title="HIV and pregnancy">HIV and pregnancy</a></div> <p>Programs to prevent the <a href="/wiki/Vertical_transmission" title="Vertical transmission">vertical transmission</a> of HIV (from mothers to children) can reduce rates of transmission by 92–99%.<sup id="cite_ref-Mother2010_84-2" class="reference"><a href="#cite_note-Mother2010-84"><span class="cite-bracket">&#91;</span>84<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Kurth2011_142-1" class="reference"><a href="#cite_note-Kurth2011-142"><span class="cite-bracket">&#91;</span>142<span class="cite-bracket">&#93;</span></a></sup> This primarily involves the use of a combination of antiviral medications during pregnancy and after birth in the infant, and potentially includes <a href="/wiki/Bottle_feeding" class="mw-redirect" title="Bottle feeding">bottle feeding</a> rather than <a href="/wiki/Breastfeeding" title="Breastfeeding">breastfeeding</a>.<sup id="cite_ref-Mother2010_84-3" class="reference"><a href="#cite_note-Mother2010-84"><span class="cite-bracket">&#91;</span>84<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-148" class="reference"><a href="#cite_note-148"><span class="cite-bracket">&#91;</span>148<span class="cite-bracket">&#93;</span></a></sup> If replacement feeding is acceptable, feasible, affordable, sustainable and safe, mothers should avoid breastfeeding their infants; however, exclusive breastfeeding is recommended during the first months of life if this is not the case.<sup id="cite_ref-149" class="reference"><a href="#cite_note-149"><span class="cite-bracket">&#91;</span>149<span class="cite-bracket">&#93;</span></a></sup> If exclusive breastfeeding is carried out, the provision of extended antiretroviral prophylaxis to the infant decreases the risk of transmission.<sup id="cite_ref-150" class="reference"><a href="#cite_note-150"><span class="cite-bracket">&#91;</span>150<span class="cite-bracket">&#93;</span></a></sup> In 2015, <a href="/wiki/Cuba" title="Cuba">Cuba</a> became the first country in the world to eradicate mother-to-child transmission of HIV.<sup id="cite_ref-151" class="reference"><a href="#cite_note-151"><span class="cite-bracket">&#91;</span>151<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Vaccination">Vaccination</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/HIV_vaccine_development" title="HIV vaccine development">HIV vaccine development</a></div> <p>Currently there is no licensed <a href="/wiki/HIV_vaccine_development" title="HIV vaccine development">vaccine for HIV or AIDS</a>.<sup id="cite_ref-UN2012Vac_12-2" class="reference"><a href="#cite_note-UN2012Vac-12"><span class="cite-bracket">&#91;</span>12<span class="cite-bracket">&#93;</span></a></sup> The most effective vaccine trial to date, <a href="/wiki/RV_144" title="RV 144">RV 144</a>, was published in 2009; it found a partial reduction in the risk of transmission of roughly 30%, stimulating some hope in the research community of developing a truly effective vaccine.<sup id="cite_ref-152" class="reference"><a href="#cite_note-152"><span class="cite-bracket">&#91;</span>152<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Management_of_HIV/AIDS" title="Management of HIV/AIDS">Management of HIV/AIDS</a></div> <p>There is currently no cure, nor an effective HIV vaccine. Treatment consists of <a href="/wiki/Highly_active_antiretroviral_therapy" class="mw-redirect" title="Highly active antiretroviral therapy">highly active antiretroviral therapy</a> (ART), which slows progression of the disease.<sup id="cite_ref-LE2011_153-0" class="reference"><a href="#cite_note-LE2011-153"><span class="cite-bracket">&#91;</span>153<span class="cite-bracket">&#93;</span></a></sup> As of 2022, 39 million people globally were living with HIV, and 29.8 million people were accessing ART.<sup id="cite_ref-:0_154-0" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> Treatment also includes preventive and active treatment of opportunistic infections. As of July 2022<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=HIV/AIDS&amp;action=edit">&#91;update&#93;</a></sup>, four people have been successfully cleared of HIV.<sup id="cite_ref-two_155-0" class="reference"><a href="#cite_note-two-155"><span class="cite-bracket">&#91;</span>155<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-156" class="reference"><a href="#cite_note-156"><span class="cite-bracket">&#91;</span>156<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-157" class="reference"><a href="#cite_note-157"><span class="cite-bracket">&#91;</span>157<span class="cite-bracket">&#93;</span></a></sup> Rapid initiation of antiretroviral therapy within one week of diagnosis appear to improve treatment outcomes in low and medium-income settings and is recommend for newly diagnosed HIV patients.<sup id="cite_ref-158" class="reference"><a href="#cite_note-158"><span class="cite-bracket">&#91;</span>158<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-159" class="reference"><a href="#cite_note-159"><span class="cite-bracket">&#91;</span>159<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Antiviral_therapy">Antiviral therapy</h3></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Stribild_bottle_Dutch_labeling.jpg" class="mw-file-description"><img alt="A white prescription bottle with the label Stribild. Next to it are ten green oblong pills with the marking 1 on one side and GSI on the other." src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Stribild_bottle_Dutch_labeling.jpg/220px-Stribild_bottle_Dutch_labeling.jpg" decoding="async" width="220" height="204" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Stribild_bottle_Dutch_labeling.jpg/330px-Stribild_bottle_Dutch_labeling.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Stribild_bottle_Dutch_labeling.jpg/440px-Stribild_bottle_Dutch_labeling.jpg 2x" data-file-width="2299" data-file-height="2129" /></a><figcaption><i><a href="/wiki/Stribild" class="mw-redirect" title="Stribild">Stribild</a></i> – a common once-daily ART regime consisting of <a href="/wiki/Elvitegravir" title="Elvitegravir">elvitegravir</a>, <a href="/wiki/Emtricitabine" title="Emtricitabine">emtricitabine</a>, <a href="/wiki/Tenofovir" class="mw-redirect" title="Tenofovir">tenofovir</a> and the booster <a href="/wiki/Cobicistat" title="Cobicistat">cobicistat</a></figcaption></figure> <p>Current ART options are combinations (or "cocktails") consisting of at least three medications belonging to at least two types, or "classes", of <a href="/wiki/Antiretroviral" class="mw-redirect" title="Antiretroviral">antiretroviral</a> agents.<sup id="cite_ref-WHOTx2010Pg19_160-0" class="reference"><a href="#cite_note-WHOTx2010Pg19-160"><span class="cite-bracket">&#91;</span>160<span class="cite-bracket">&#93;</span></a></sup> There are eight classes of antiretroviral agents (ARVs), and over 30 individual drugs: nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase, inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand transfer inhibitors (INSTIs), a fusion inhibitor, a CCR5 antagonist, a CD4 T lymphocyte (CD4) post-attachment inhibitor, and a gp120 attachment inhibitor. There are also two drugs, ritonavir (RTV) and cobicistat (COBI) which can be used as pharmacokinetic (PK) enhancers (or boosters) to improve the PK profiles of PIs and the INSTI elvitegravir (EVG).<sup id="cite_ref-:1_161-0" class="reference"><a href="#cite_note-:1-161"><span class="cite-bracket">&#91;</span>161<span class="cite-bracket">&#93;</span></a></sup> Depending on the guidelines being followed, initial treatment generally consists of two nucleoside reverse transcriptase inhibitors along with a third ARV, either an integrase strand transfer inhibitor (INSTI), a non-nucleoside reverse transcriptase inhibitor (NNRTI), or a protease inhibitor with a pharmacokinetic enhancer (also known as a booster).<sup id="cite_ref-:1_161-1" class="reference"><a href="#cite_note-:1-161"><span class="cite-bracket">&#91;</span>161<span class="cite-bracket">&#93;</span></a></sup> </p><p>The World Health Organization and the United States recommend antiretrovirals in people of all ages (including pregnant women) as soon as the diagnosis is made, regardless of CD4 count.<sup id="cite_ref-WHO2015Tx_14-1" class="reference"><a href="#cite_note-WHO2015Tx-14"><span class="cite-bracket">&#91;</span>14<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-IAS2014_162-0" class="reference"><a href="#cite_note-IAS2014-162"><span class="cite-bracket">&#91;</span>162<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-DHHS2013_163-0" class="reference"><a href="#cite_note-DHHS2013-163"><span class="cite-bracket">&#91;</span>163<span class="cite-bracket">&#93;</span></a></sup> Once treatment is begun, it is recommended that it is continued without breaks or "holidays".<sup id="cite_ref-Deut2010_33-4" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Many people are diagnosed only after treatment ideally should have begun.<sup id="cite_ref-Deut2010_33-5" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> The desired outcome of treatment is a long-term plasma HIV-RNA count below 50&#160;copies/mL.<sup id="cite_ref-Deut2010_33-6" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Levels to determine if treatment is effective are initially recommended after four weeks and once levels fall below 50&#160;copies/mL checks every three to six months are typically adequate.<sup id="cite_ref-Deut2010_33-7" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Inadequate control is deemed to be greater than 400&#160;copies/mL.<sup id="cite_ref-Deut2010_33-8" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Based on these criteria treatment is effective in more than 95% of people during the first year.<sup id="cite_ref-Deut2010_33-9" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> </p><p>Benefits of treatment include a decreased risk of progression to AIDS and a decreased risk of death.<sup id="cite_ref-164" class="reference"><a href="#cite_note-164"><span class="cite-bracket">&#91;</span>164<span class="cite-bracket">&#93;</span></a></sup> In the developing world, treatment also improves physical and mental health.<sup id="cite_ref-165" class="reference"><a href="#cite_note-165"><span class="cite-bracket">&#91;</span>165<span class="cite-bracket">&#93;</span></a></sup> With treatment, there is a 70% reduced risk of acquiring tuberculosis.<sup id="cite_ref-WHOTx2010Pg19_160-1" class="reference"><a href="#cite_note-WHOTx2010Pg19-160"><span class="cite-bracket">&#91;</span>160<span class="cite-bracket">&#93;</span></a></sup> Additional benefits include a decreased risk of transmission of the disease to sexual partners and a decrease in mother-to-child transmission.<sup id="cite_ref-WHOTx2010Pg19_160-2" class="reference"><a href="#cite_note-WHOTx2010Pg19-160"><span class="cite-bracket">&#91;</span>160<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-166" class="reference"><a href="#cite_note-166"><span class="cite-bracket">&#91;</span>166<span class="cite-bracket">&#93;</span></a></sup> The effectiveness of treatment depends to a large part on compliance.<sup id="cite_ref-Deut2010_33-10" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Reasons for non-adherence to treatment include poor access to medical care,<sup id="cite_ref-167" class="reference"><a href="#cite_note-167"><span class="cite-bracket">&#91;</span>167<span class="cite-bracket">&#93;</span></a></sup> inadequate social supports, <a href="/wiki/Mental_illness" class="mw-redirect" title="Mental illness">mental illness</a> and <a href="/wiki/Drug_abuse" class="mw-redirect" title="Drug abuse">drug abuse</a>.<sup id="cite_ref-168" class="reference"><a href="#cite_note-168"><span class="cite-bracket">&#91;</span>168<span class="cite-bracket">&#93;</span></a></sup> The complexity of treatment regimens (due to pill numbers and dosing frequency) and <a href="/wiki/Adverse_effect" title="Adverse effect">adverse effects</a> may reduce adherence.<sup id="cite_ref-pmid21406048_169-0" class="reference"><a href="#cite_note-pmid21406048-169"><span class="cite-bracket">&#91;</span>169<span class="cite-bracket">&#93;</span></a></sup> Even though cost is an important issue with some medications,<sup id="cite_ref-170" class="reference"><a href="#cite_note-170"><span class="cite-bracket">&#91;</span>170<span class="cite-bracket">&#93;</span></a></sup> 47% of those who needed them were taking them in low- and middle-income countries as of 2010<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=HIV/AIDS&amp;action=edit">&#91;update&#93;</a></sup>,<sup id="cite_ref-UN2011Ten_171-0" class="reference"><a href="#cite_note-UN2011Ten-171"><span class="cite-bracket">&#91;</span>171<span class="cite-bracket">&#93;</span></a></sup> and the rate of adherence is similar in low-income and high-income countries.<sup id="cite_ref-172" class="reference"><a href="#cite_note-172"><span class="cite-bracket">&#91;</span>172<span class="cite-bracket">&#93;</span></a></sup> </p><p>Specific adverse events are related to the antiretroviral agent taken.<sup id="cite_ref-Montessori2004_173-0" class="reference"><a href="#cite_note-Montessori2004-173"><span class="cite-bracket">&#91;</span>173<span class="cite-bracket">&#93;</span></a></sup> Some relatively common adverse events include: <a href="/wiki/HIV-associated_lipodystrophy" title="HIV-associated lipodystrophy">lipodystrophy syndrome</a>, <a href="/wiki/Dyslipidemia" title="Dyslipidemia">dyslipidemia</a>, and <a href="/wiki/Diabetes_mellitus" class="mw-redirect" title="Diabetes mellitus">diabetes mellitus</a>, especially with protease inhibitors.<sup id="cite_ref-M121_29-5" class="reference"><a href="#cite_note-M121-29"><span class="cite-bracket">&#91;</span>29<span class="cite-bracket">&#93;</span></a></sup> Other common symptoms include diarrhea,<sup id="cite_ref-Montessori2004_173-1" class="reference"><a href="#cite_note-Montessori2004-173"><span class="cite-bracket">&#91;</span>173<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Burgoyne2008_174-0" class="reference"><a href="#cite_note-Burgoyne2008-174"><span class="cite-bracket">&#91;</span>174<span class="cite-bracket">&#93;</span></a></sup> and an increased risk of <a href="/wiki/Cardiovascular_disease" title="Cardiovascular disease">cardiovascular disease</a>.<sup id="cite_ref-175" class="reference"><a href="#cite_note-175"><span class="cite-bracket">&#91;</span>175<span class="cite-bracket">&#93;</span></a></sup> Newer recommended treatments are associated with fewer adverse effects.<sup id="cite_ref-Deut2010_33-11" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> Certain medications may be associated with <a href="/wiki/Birth_defect" title="Birth defect">birth defects</a> and therefore may be unsuitable for women hoping to have children.<sup id="cite_ref-Deut2010_33-12" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> </p><p>Treatment recommendations for children are somewhat different from those for adults. The World Health Organization recommends treating all children less than five years of age; children above five are treated like adults.<sup id="cite_ref-WHOCARV2013_176-0" class="reference"><a href="#cite_note-WHOCARV2013-176"><span class="cite-bracket">&#91;</span>176<span class="cite-bracket">&#93;</span></a></sup> The United States guidelines recommend treating all children less than 12 months of age and all those with HIV RNA counts greater than 100,000&#160;copies/mL between one year and five years of age.<sup id="cite_ref-DHHS2014_177-0" class="reference"><a href="#cite_note-DHHS2014-177"><span class="cite-bracket">&#91;</span>177<span class="cite-bracket">&#93;</span></a></sup> </p><p>The <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) has recommended the granting of marketing authorizations for two new antiretroviral (ARV) medicines, <a href="/wiki/Rilpivirine" title="Rilpivirine">rilpivirine</a> (Rekambys) and <a href="/wiki/Cabotegravir" title="Cabotegravir">cabotegravir</a> (Vocabria), to be used together for the treatment of people with human immunodeficiency virus type 1 (HIV-1) infection.<sup id="cite_ref-EMA_PR_178-0" class="reference"><a href="#cite_note-EMA_PR-178"><span class="cite-bracket">&#91;</span>178<span class="cite-bracket">&#93;</span></a></sup> The two medicines are the first ARVs that come in a long-acting injectable formulation.<sup id="cite_ref-EMA_PR_178-1" class="reference"><a href="#cite_note-EMA_PR-178"><span class="cite-bracket">&#91;</span>178<span class="cite-bracket">&#93;</span></a></sup> This means that instead of daily pills, people receive intramuscular injections monthly or every two months.<sup id="cite_ref-EMA_PR_178-2" class="reference"><a href="#cite_note-EMA_PR-178"><span class="cite-bracket">&#91;</span>178<span class="cite-bracket">&#93;</span></a></sup> </p><p>The combination of Rekambys and Vocabria injection is intended for maintenance treatment of adults who have undetectable HIV levels in the blood (viral load less than 50 copies/mL) with their current ARV treatment, and when the virus has not developed resistance to a certain class of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs) and integrase strand transfer inhibitors (INIs).<sup id="cite_ref-EMA_PR_178-3" class="reference"><a href="#cite_note-EMA_PR-178"><span class="cite-bracket">&#91;</span>178<span class="cite-bracket">&#93;</span></a></sup> </p><p><a href="/wiki/Cabotegravir/rilpivirine" title="Cabotegravir/rilpivirine">Cabotegravir combined with rilpivirine</a> (Cabenuva) is a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults to replace a current antiretroviral regimen in those who are virologically suppressed on a stable antiretroviral regimen with no history of treatment failure and with no known or suspected resistance to either <a href="/wiki/Cabotegravir" title="Cabotegravir">cabotegravir</a> or <a href="/wiki/Rilpivirine" title="Rilpivirine">rilpivirine</a>.<sup id="cite_ref-FDA_PR_179-0" class="reference"><a href="#cite_note-FDA_PR-179"><span class="cite-bracket">&#91;</span>179<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-180" class="reference"><a href="#cite_note-180"><span class="cite-bracket">&#91;</span>180<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Opportunistic_infections">Opportunistic infections</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Opportunistic_infection#Opportunistic_Infection_and_HIV/AIDS" title="Opportunistic infection">Opportunistic infection §&#160;Opportunistic Infection and HIV/AIDS</a></div> <p>Measures to prevent opportunistic infections are effective in many people with HIV/AIDS. In addition to improving current disease, treatment with antiretrovirals reduces the risk of developing additional opportunistic infections.<sup id="cite_ref-Montessori2004_173-2" class="reference"><a href="#cite_note-Montessori2004-173"><span class="cite-bracket">&#91;</span>173<span class="cite-bracket">&#93;</span></a></sup> </p><p>Adults and adolescents who are living with HIV (even on anti-retroviral therapy) with no evidence of active tuberculosis in settings with high tuberculosis burden should receive <a href="/wiki/Isoniazid" title="Isoniazid">isoniazid preventive therapy</a> (IPT); the <a href="/wiki/Mantoux_test" title="Mantoux test">tuberculin skin test</a> can be used to help decide if IPT is needed.<sup id="cite_ref-WHOHIVTB2011_181-0" class="reference"><a href="#cite_note-WHOHIVTB2011-181"><span class="cite-bracket">&#91;</span>181<span class="cite-bracket">&#93;</span></a></sup> Children with HIV may benefit from screening for tuberculosis.<sup id="cite_ref-182" class="reference"><a href="#cite_note-182"><span class="cite-bracket">&#91;</span>182<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Vaccination" title="Vaccination">Vaccination</a> against <a href="/wiki/Hepatitis" title="Hepatitis">hepatitis</a> A and B is advised for all people at risk of HIV before they become infected; however, it may also be given after infection.<sup id="cite_ref-Laurence_183-0" class="reference"><a href="#cite_note-Laurence-183"><span class="cite-bracket">&#91;</span>183<span class="cite-bracket">&#93;</span></a></sup> </p><p><a href="/wiki/Trimethoprim/sulfamethoxazole" title="Trimethoprim/sulfamethoxazole">Trimethoprim/sulfamethoxazole</a> prophylaxis between four and six weeks of age, and ceasing breastfeeding of infants born to HIV-positive mothers, is recommended in resource-limited settings.<sup id="cite_ref-UN2011ONESIXTY_184-0" class="reference"><a href="#cite_note-UN2011ONESIXTY-184"><span class="cite-bracket">&#91;</span>184<span class="cite-bracket">&#93;</span></a></sup> It is also recommended to prevent PCP when a person's CD4 count is below 200&#160;cells/uL and in those who have or have previously had PCP.<sup id="cite_ref-PCP2011_185-0" class="reference"><a href="#cite_note-PCP2011-185"><span class="cite-bracket">&#91;</span>185<span class="cite-bracket">&#93;</span></a></sup> People with substantial immunosuppression are also advised to receive prophylactic therapy for <a href="/wiki/Toxoplasmosis" title="Toxoplasmosis">toxoplasmosis</a> and <a href="/wiki/Mycobacterium_avium-intracellulare_infection" title="Mycobacterium avium-intracellulare infection">MAC</a>.<sup id="cite_ref-PEPpocketguide_186-0" class="reference"><a href="#cite_note-PEPpocketguide-186"><span class="cite-bracket">&#91;</span>186<span class="cite-bracket">&#93;</span></a></sup> Appropriate preventive measures reduced the rate of these infections by 50% between 1992 and 1997.<sup id="cite_ref-InfectionBook2008_187-0" class="reference"><a href="#cite_note-InfectionBook2008-187"><span class="cite-bracket">&#91;</span>187<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Influenza_vaccination" class="mw-redirect" title="Influenza vaccination">Influenza vaccination</a> and <a href="/wiki/Pneumococcal_polysaccharide_vaccine" title="Pneumococcal polysaccharide vaccine">pneumococcal polysaccharide vaccine</a> are often recommended in people with HIV/AIDS with some evidence of benefit.<sup id="cite_ref-188" class="reference"><a href="#cite_note-188"><span class="cite-bracket">&#91;</span>188<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-189" class="reference"><a href="#cite_note-189"><span class="cite-bracket">&#91;</span>189<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Diet">Diet</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Nutrition_and_HIV/AIDS" class="mw-redirect" title="Nutrition and HIV/AIDS">Nutrition and HIV/AIDS</a></div> <p>The World Health Organization (WHO) has issued recommendations regarding nutrient requirements in HIV/AIDS.<sup id="cite_ref-WHO_nutrients_190-0" class="reference"><a href="#cite_note-WHO_nutrients-190"><span class="cite-bracket">&#91;</span>190<span class="cite-bracket">&#93;</span></a></sup> A generally healthy diet is promoted. Dietary intake of micronutrients at <a href="/wiki/Reference_Daily_Intake" title="Reference Daily Intake">RDA</a> levels by HIV-infected adults is recommended by the WHO; higher intake of <a href="/wiki/Vitamin_A" title="Vitamin A">vitamin A</a>, <a href="/wiki/Zinc" title="Zinc">zinc</a>, and iron can produce adverse effects in HIV-positive adults, and is not recommended unless there is documented deficiency.<sup id="cite_ref-WHO_nutrients_190-1" class="reference"><a href="#cite_note-WHO_nutrients-190"><span class="cite-bracket">&#91;</span>190<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-191" class="reference"><a href="#cite_note-191"><span class="cite-bracket">&#91;</span>191<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-192" class="reference"><a href="#cite_note-192"><span class="cite-bracket">&#91;</span>192<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-193" class="reference"><a href="#cite_note-193"><span class="cite-bracket">&#91;</span>193<span class="cite-bracket">&#93;</span></a></sup> Dietary supplementation for people who are infected with HIV and who have inadequate nutrition or dietary deficiencies may strengthen their immune systems or help them recover from infections; however, evidence indicating an overall benefit in morbidity or reduction in mortality is not consistent.<sup id="cite_ref-194" class="reference"><a href="#cite_note-194"><span class="cite-bracket">&#91;</span>194<span class="cite-bracket">&#93;</span></a></sup> </p><p>People with HIV/AIDS are up to four times more likely to develop type 2 <a href="/wiki/Diabetes" title="Diabetes">diabetes</a> than those who are not tested positive with the virus.<sup id="cite_ref-195" class="reference"><a href="#cite_note-195"><span class="cite-bracket">&#91;</span>195<span class="cite-bracket">&#93;</span></a></sup> </p><p>Evidence for supplementation with <a href="/wiki/Selenium" title="Selenium">selenium</a> is mixed with some tentative evidence of benefit.<sup id="cite_ref-196" class="reference"><a href="#cite_note-196"><span class="cite-bracket">&#91;</span>196<span class="cite-bracket">&#93;</span></a></sup> For pregnant and lactating women with HIV, <a href="/wiki/Multivitamin" title="Multivitamin">multivitamin</a> supplement improves outcomes for both mothers and children.<sup id="cite_ref-Siegfried2012_197-0" class="reference"><a href="#cite_note-Siegfried2012-197"><span class="cite-bracket">&#91;</span>197<span class="cite-bracket">&#93;</span></a></sup> If the pregnant or lactating mother has been advised to take anti-retroviral medication to prevent mother-to-child HIV transmission, multivitamin supplements should not replace these treatments.<sup id="cite_ref-Siegfried2012_197-1" class="reference"><a href="#cite_note-Siegfried2012-197"><span class="cite-bracket">&#91;</span>197<span class="cite-bracket">&#93;</span></a></sup> There is some evidence that vitamin A supplementation in children with an HIV infection reduces mortality and improves growth.<sup id="cite_ref-198" class="reference"><a href="#cite_note-198"><span class="cite-bracket">&#91;</span>198<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Alternative_medicine">Alternative medicine</h3></div> <p>In the US, approximately 60% of people with HIV use various forms of <a href="/wiki/Alternative_medicine" title="Alternative medicine">complementary or alternative medicine</a>,<sup id="cite_ref-pmid18608078_199-0" class="reference"><a href="#cite_note-pmid18608078-199"><span class="cite-bracket">&#91;</span>199<span class="cite-bracket">&#93;</span></a></sup> whose effectiveness has not been established.<sup id="cite_ref-pmid15969772_200-0" class="reference"><a href="#cite_note-pmid15969772-200"><span class="cite-bracket">&#91;</span>200<span class="cite-bracket">&#93;</span></a></sup> There is not enough evidence to support the use of <a href="/wiki/Herbal_medicine" title="Herbal medicine">herbal medicines</a>.<sup id="cite_ref-201" class="reference"><a href="#cite_note-201"><span class="cite-bracket">&#91;</span>201<span class="cite-bracket">&#93;</span></a></sup> There is insufficient evidence to recommend or support the use of <a href="/wiki/Medical_cannabis" title="Medical cannabis">medical cannabis</a> to try to increase appetite or weight gain.<sup id="cite_ref-lutge_2013_202-0" class="reference"><a href="#cite_note-lutge_2013-202"><span class="cite-bracket">&#91;</span>202<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Prognosis">Prognosis</h2></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:HIV-AIDS_world_map-Deaths_per_million_persons-WHO2012.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/67/HIV-AIDS_world_map-Deaths_per_million_persons-WHO2012.svg/290px-HIV-AIDS_world_map-Deaths_per_million_persons-WHO2012.svg.png" decoding="async" width="290" height="128" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/67/HIV-AIDS_world_map-Deaths_per_million_persons-WHO2012.svg/435px-HIV-AIDS_world_map-Deaths_per_million_persons-WHO2012.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/67/HIV-AIDS_world_map-Deaths_per_million_persons-WHO2012.svg/580px-HIV-AIDS_world_map-Deaths_per_million_persons-WHO2012.svg.png 2x" data-file-width="940" data-file-height="415" /></a><figcaption>Deaths due to HIV/AIDS per million people in 2012: <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col div-col-small" style="column-width: 10em;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffff20; color:black;">&#160;</span>&#160;0</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffe820; color:black;">&#160;</span>&#160;1–4</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffd820; color:black;">&#160;</span>&#160;5–12</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffc020; color:black;">&#160;</span>&#160;13–34</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffa020; color:black;">&#160;</span>&#160;35–61</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ff9a20; color:black;">&#160;</span>&#160;62–134</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#f08015; color:black;">&#160;</span>&#160;135–215</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#e06815; color:black;">&#160;</span>&#160;216–458</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#d85010; color:black;">&#160;</span>&#160;459–1,402</div><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#d02010; color:white;">&#160;</span>&#160;1,403–5,828</div></div></figcaption></figure> <p>HIV/AIDS has become a <a href="/wiki/Chronic_(medicine)" class="mw-redirect" title="Chronic (medicine)">chronic</a> rather than an acutely fatal disease in many areas of the world.<sup id="cite_ref-Knoll2007_203-0" class="reference"><a href="#cite_note-Knoll2007-203"><span class="cite-bracket">&#91;</span>203<span class="cite-bracket">&#93;</span></a></sup> Prognosis varies between people, and both the CD4 count and viral load are useful for predicted outcomes.<sup id="cite_ref-M118_32-14" class="reference"><a href="#cite_note-M118-32"><span class="cite-bracket">&#91;</span>32<span class="cite-bracket">&#93;</span></a></sup> Without treatment, average survival time after infection with HIV is estimated to be 9 to 11&#160;years, depending on the HIV subtype.<sup id="cite_ref-UNAIDS2007_6-2" class="reference"><a href="#cite_note-UNAIDS2007-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> After the diagnosis of AIDS, if treatment is not available, survival ranges between 6 and 19&#160;months.<sup id="cite_ref-Morgan2_204-0" class="reference"><a href="#cite_note-Morgan2-204"><span class="cite-bracket">&#91;</span>204<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-205" class="reference"><a href="#cite_note-205"><span class="cite-bracket">&#91;</span>205<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/HAART" class="mw-redirect" title="HAART">ART</a> and appropriate prevention of opportunistic infections reduces the death rate by 80%, and raises the life expectancy for a newly diagnosed young adult to 20–50 years.<sup id="cite_ref-Knoll2007_203-1" class="reference"><a href="#cite_note-Knoll2007-203"><span class="cite-bracket">&#91;</span>203<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-LifeExpecr2008_206-0" class="reference"><a href="#cite_note-LifeExpecr2008-206"><span class="cite-bracket">&#91;</span>206<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Schack2006_207-0" class="reference"><a href="#cite_note-Schack2006-207"><span class="cite-bracket">&#91;</span>207<span class="cite-bracket">&#93;</span></a></sup> This is between two thirds<sup id="cite_ref-LifeExpecr2008_206-1" class="reference"><a href="#cite_note-LifeExpecr2008-206"><span class="cite-bracket">&#91;</span>206<span class="cite-bracket">&#93;</span></a></sup> and nearly that of the general population.<sup id="cite_ref-Deut2010_33-13" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-208" class="reference"><a href="#cite_note-208"><span class="cite-bracket">&#91;</span>208<span class="cite-bracket">&#93;</span></a></sup> If treatment is started late in the infection, prognosis is not as good:<sup id="cite_ref-Deut2010_33-14" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> for example, if treatment is begun following the diagnosis of AIDS, life expectancy is ~10–40&#160;years.<sup id="cite_ref-Deut2010_33-15" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Knoll2007_203-2" class="reference"><a href="#cite_note-Knoll2007-203"><span class="cite-bracket">&#91;</span>203<span class="cite-bracket">&#93;</span></a></sup> Half of infants born with HIV die before two years of age without treatment.<sup id="cite_ref-UN2011ONESIXTY_184-1" class="reference"><a href="#cite_note-UN2011ONESIXTY-184"><span class="cite-bracket">&#91;</span>184<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-209" class="reference"><a href="#cite_note-209"><span class="cite-bracket">&#91;</span>209<span class="cite-bracket">&#93;</span></a></sup> </p> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:HIV-AIDS_world_map_-_DALY_-_WHO2004.svg" class="mw-file-description"><img alt="A map of the world where much of it is colored yellow or orange except for sub Saharan Africa which is colored red or dark red" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/HIV-AIDS_world_map_-_DALY_-_WHO2004.svg/290px-HIV-AIDS_world_map_-_DALY_-_WHO2004.svg.png" decoding="async" width="290" height="128" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/HIV-AIDS_world_map_-_DALY_-_WHO2004.svg/435px-HIV-AIDS_world_map_-_DALY_-_WHO2004.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/HIV-AIDS_world_map_-_DALY_-_WHO2004.svg/580px-HIV-AIDS_world_map_-_DALY_-_WHO2004.svg.png 2x" data-file-width="940" data-file-height="415" /></a><figcaption><a href="/wiki/Disability-adjusted_life_year" title="Disability-adjusted life year">Disability-adjusted life year</a> for HIV and AIDS per 100,000&#160;inhabitants as of 2004: <style data-mw-deduplicate="TemplateStyles:r1216972533">.mw-parser-output .col-begin{border-collapse:collapse;padding:0;color:inherit;width:100%;border:0;margin:0}.mw-parser-output .col-begin-small{font-size:90%}.mw-parser-output .col-break{vertical-align:top;text-align:left}.mw-parser-output .col-break-2{width:50%}.mw-parser-output .col-break-3{width:33.3%}.mw-parser-output .col-break-4{width:25%}.mw-parser-output .col-break-5{width:20%}@media(max-width:720px){.mw-parser-output .col-begin,.mw-parser-output .col-begin>tbody,.mw-parser-output .col-begin>tbody>tr,.mw-parser-output .col-begin>tbody>tr>td{display:block!important;width:100%!important}.mw-parser-output .col-break{padding-left:0!important}}</style><div> <table class="col-begin" role="presentation"> <tbody><tr> <td class="col-break"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#b3b3b3; color:black;">&#160;</span>&#160;<small>no data</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffff65; color:black;">&#160;</span>&#160;<small>≤&#160;10</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#fff200; color:black;">&#160;</span>&#160;<small>10–25</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffdc00; color:black;">&#160;</span>&#160;<small>25–50</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffc600; color:black;">&#160;</span>&#160;<small>50–100</small></div> </td> <td class="col-break"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ffb000; color:black;">&#160;</span>&#160;<small>100–500</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ff9a00; color:black;">&#160;</span>&#160;<small>500–1000</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ff8400; color:black;">&#160;</span>&#160;<small>1,000–2,500</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ff6e00; color:black;">&#160;</span>&#160;<small>2,500–5,000</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ff5800; color:black;">&#160;</span>&#160;<small>5,000–7500</small></div> </td> <td class="col-break"> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ff4200; color:black;">&#160;</span>&#160;<small>7,500–10,000</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#ff2c00; color:black;">&#160;</span>&#160;<small>10,000–50,000</small></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r981673959"><div class="legend"><span class="legend-color mw-no-invert" style="background-color:#cb0000; color:white;">&#160;</span>&#160;<small>≥&#160;50,000</small></div> &#32; </td></tr></tbody></table></div></figcaption></figure> <p>The primary causes of death from HIV/AIDS are <a href="/wiki/Opportunistic_infections" class="mw-redirect" title="Opportunistic infections">opportunistic infections</a> and <a href="/wiki/Cancer" title="Cancer">cancer</a>, both of which are frequently the result of the progressive failure of the immune system.<sup id="cite_ref-InfectionBook2008_187-1" class="reference"><a href="#cite_note-InfectionBook2008-187"><span class="cite-bracket">&#91;</span>187<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Cancer2005_210-0" class="reference"><a href="#cite_note-Cancer2005-210"><span class="cite-bracket">&#91;</span>210<span class="cite-bracket">&#93;</span></a></sup> Risk of cancer appears to increase once the CD4 count is below 500/μL.<sup id="cite_ref-Deut2010_33-16" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup> The rate of clinical disease progression varies widely between individuals and has been shown to be affected by a number of factors such as a person's susceptibility and immune function;<sup id="cite_ref-Tang_211-0" class="reference"><a href="#cite_note-Tang-211"><span class="cite-bracket">&#91;</span>211<span class="cite-bracket">&#93;</span></a></sup> their access to health care, the presence of co-infections;<sup id="cite_ref-Morgan2_204-1" class="reference"><a href="#cite_note-Morgan2-204"><span class="cite-bracket">&#91;</span>204<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Lawn_212-0" class="reference"><a href="#cite_note-Lawn-212"><span class="cite-bracket">&#91;</span>212<span class="cite-bracket">&#93;</span></a></sup> and the particular strain (or strains) of the virus involved.<sup id="cite_ref-Campbell_213-0" class="reference"><a href="#cite_note-Campbell-213"><span class="cite-bracket">&#91;</span>213<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Campbell2_214-0" class="reference"><a href="#cite_note-Campbell2-214"><span class="cite-bracket">&#91;</span>214<span class="cite-bracket">&#93;</span></a></sup> </p><p><a href="/wiki/Tuberculosis" title="Tuberculosis">Tuberculosis</a> co-infection is one of the leading causes of sickness and death in those with HIV/AIDS being present in a third of all HIV-infected people and causing 25% of HIV-related deaths.<sup id="cite_ref-215" class="reference"><a href="#cite_note-215"><span class="cite-bracket">&#91;</span>215<span class="cite-bracket">&#93;</span></a></sup> HIV is also one of the most important risk factors for tuberculosis.<sup id="cite_ref-WHO2011_216-0" class="reference"><a href="#cite_note-WHO2011-216"><span class="cite-bracket">&#91;</span>216<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Hepatitis_C" title="Hepatitis C">Hepatitis C</a> is another very common co-infection where each disease increases the progression of the other.<sup id="cite_ref-217" class="reference"><a href="#cite_note-217"><span class="cite-bracket">&#91;</span>217<span class="cite-bracket">&#93;</span></a></sup> The two most common cancers associated with HIV/AIDS are <a href="/wiki/Kaposi%27s_sarcoma" title="Kaposi&#39;s sarcoma">Kaposi's sarcoma</a> and AIDS-related <a href="/wiki/Non-Hodgkin%27s_lymphoma" class="mw-redirect" title="Non-Hodgkin&#39;s lymphoma">non-Hodgkin's lymphoma</a>.<sup id="cite_ref-Cancer2005_210-1" class="reference"><a href="#cite_note-Cancer2005-210"><span class="cite-bracket">&#91;</span>210<span class="cite-bracket">&#93;</span></a></sup> Other cancers that are more frequent include <a href="/wiki/Anal_cancer" title="Anal cancer">anal cancer</a>, <a href="/wiki/Burkitt%27s_lymphoma" class="mw-redirect" title="Burkitt&#39;s lymphoma">Burkitt's lymphoma</a>, <a href="/wiki/Primary_central_nervous_system_lymphoma" title="Primary central nervous system lymphoma">primary central nervous system lymphoma</a>, and <a href="/wiki/Cervical_cancer" title="Cervical cancer">cervical cancer</a>.<sup id="cite_ref-Deut2010_33-17" class="reference"><a href="#cite_note-Deut2010-33"><span class="cite-bracket">&#91;</span>33<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-218" class="reference"><a href="#cite_note-218"><span class="cite-bracket">&#91;</span>218<span class="cite-bracket">&#93;</span></a></sup> </p><p>Even with anti-retroviral treatment, over the long term HIV-infected people may experience <a href="/wiki/AIDS_dementia_complex" class="mw-redirect" title="AIDS dementia complex">neurocognitive disorders</a>,<sup id="cite_ref-Woods2009_219-0" class="reference"><a href="#cite_note-Woods2009-219"><span class="cite-bracket">&#91;</span>219<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Osteoporosis" title="Osteoporosis">osteoporosis</a>,<sup id="cite_ref-Brown2006_220-0" class="reference"><a href="#cite_note-Brown2006-220"><span class="cite-bracket">&#91;</span>220<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">neuropathy</a>,<sup id="cite_ref-Nicholas2007_221-0" class="reference"><a href="#cite_note-Nicholas2007-221"><span class="cite-bracket">&#91;</span>221<span class="cite-bracket">&#93;</span></a></sup> cancers,<sup id="cite_ref-Boshoff2002_222-0" class="reference"><a href="#cite_note-Boshoff2002-222"><span class="cite-bracket">&#91;</span>222<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Yarchoan2005_223-0" class="reference"><a href="#cite_note-Yarchoan2005-223"><span class="cite-bracket">&#91;</span>223<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/Nephropathy" class="mw-redirect" title="Nephropathy">nephropathy</a>,<sup id="cite_ref-Post2009_224-0" class="reference"><a href="#cite_note-Post2009-224"><span class="cite-bracket">&#91;</span>224<span class="cite-bracket">&#93;</span></a></sup> and <a href="/wiki/Cardiovascular_disease" title="Cardiovascular disease">cardiovascular disease</a>.<sup id="cite_ref-Burgoyne2008_174-1" class="reference"><a href="#cite_note-Burgoyne2008-174"><span class="cite-bracket">&#91;</span>174<span class="cite-bracket">&#93;</span></a></sup> Some conditions, such as <a href="/wiki/Lipodystrophy" title="Lipodystrophy">lipodystrophy</a>, may be caused both by HIV and its treatment.<sup id="cite_ref-Burgoyne2008_174-2" class="reference"><a href="#cite_note-Burgoyne2008-174"><span class="cite-bracket">&#91;</span>174<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Epidemiology_of_HIV/AIDS" title="Epidemiology of HIV/AIDS">Epidemiology of HIV/AIDS</a></div> <div class="thumb tright" style=""><div class="thumbinner" style="width:522px"><div class="thumbimage noresize" style="width:520px;"> <style data-mw-deduplicate="TemplateStyles:r1251242444">.mw-parser-output .ambox{border:1px solid #a2a9b1;border-left:10px solid #36c;background-color:#fbfbfb;box-sizing:border-box}.mw-parser-output .ambox+link+.ambox,.mw-parser-output .ambox+link+style+.ambox,.mw-parser-output .ambox+link+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+style+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+link+.ambox{margin-top:-1px}html body.mediawiki .mw-parser-output .ambox.mbox-small-left{margin:4px 1em 4px 0;overflow:hidden;width:238px;border-collapse:collapse;font-size:88%;line-height:1.25em}.mw-parser-output .ambox-speedy{border-left:10px solid #b32424;background-color:#fee7e6}.mw-parser-output .ambox-delete{border-left:10px solid #b32424}.mw-parser-output .ambox-content{border-left:10px solid #f28500}.mw-parser-output .ambox-style{border-left:10px solid #fc3}.mw-parser-output .ambox-move{border-left:10px solid #9932cc}.mw-parser-output .ambox-protection{border-left:10px solid #a2a9b1}.mw-parser-output .ambox .mbox-text{border:none;padding:0.25em 0.5em;width:100%}.mw-parser-output .ambox .mbox-image{border:none;padding:2px 0 2px 0.5em;text-align:center}.mw-parser-output .ambox .mbox-imageright{border:none;padding:2px 0.5em 2px 0;text-align:center}.mw-parser-output .ambox .mbox-empty-cell{border:none;padding:0;width:1px}.mw-parser-output .ambox .mbox-image-div{width:52px}@media(min-width:720px){.mw-parser-output .ambox{margin:0 10%}}@media print{body.ns-0 .mw-parser-output .ambox{display:none!important}}</style><table class="box-Notice plainlinks metadata ambox ambox-notice" role="presentation" style="width:100%;margin:0;"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/1/1d/Information_icon4.svg/40px-Information_icon4.svg.png" decoding="async" width="40" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/1/1d/Information_icon4.svg/60px-Information_icon4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/1/1d/Information_icon4.svg/80px-Information_icon4.svg.png 2x" data-file-width="620" data-file-height="620" /></span></span></div></td><td class="mbox-text" style="text-align: left;"><div class="mbox-text-span">Graphs are unavailable due to technical issues. There is more info on <a href="https://phabricator.wikimedia.org/T334940" class="extiw" title="phab:T334940">Phabricator</a> and on <a href="https://www.mediawiki.org/wiki/Extension:Graph/Plans" class="extiw" title="mw:Extension:Graph/Plans">MediaWiki.org</a>.</div></td></tr></tbody></table> <small>See or edit <a href="https://commons.wikimedia.org/wiki/Data:HIV_rates.tab" class="extiw" title="c:Data:HIV rates.tab">source data</a>. </small></div><div class="thumbcaption">Percentage of people with HIV/AIDS<sup id="cite_ref-auto_225-0" class="reference"><a href="#cite_note-auto-225"><span class="cite-bracket">&#91;</span>225<span class="cite-bracket">&#93;</span></a></sup></div></div></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Deaths-and-new-cases-of-hiv.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Deaths-and-new-cases-of-hiv.png/400px-Deaths-and-new-cases-of-hiv.png" decoding="async" width="400" height="243" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Deaths-and-new-cases-of-hiv.png/600px-Deaths-and-new-cases-of-hiv.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Deaths-and-new-cases-of-hiv.png/800px-Deaths-and-new-cases-of-hiv.png 2x" data-file-width="3258" data-file-height="1978" /></a><figcaption>Trends in new cases and deaths per year from HIV/AIDS, 1990-2017<sup id="cite_ref-auto_225-1" class="reference"><a href="#cite_note-auto-225"><span class="cite-bracket">&#91;</span>225<span class="cite-bracket">&#93;</span></a></sup></figcaption></figure> <p>HIV/AIDS is considered a global <a href="/wiki/Pandemic" title="Pandemic">pandemic</a>.<sup id="cite_ref-Cohen2008_226-0" class="reference"><a href="#cite_note-Cohen2008-226"><span class="cite-bracket">&#91;</span>226<span class="cite-bracket">&#93;</span></a></sup> As of 2022<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=HIV/AIDS&amp;action=edit">&#91;update&#93;</a></sup>, approximately 39.0&#160;million people worldwide are living with HIV, the number of new infections that year being about 1.3&#160;million.<sup id="cite_ref-:0_154-1" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> This is down from 2.1&#160;million new infections in 2010.<sup id="cite_ref-:0_154-2" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> Among new infections, 46% are in women and are children globally.<sup id="cite_ref-:0_154-3" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> There were 630,000 AIDS related deaths in 2022, down from a peak of 2&#160;million in 2005.<sup id="cite_ref-:0_154-4" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> The <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> has reported that deaths from HIV and AIDS have "fallen by 61%, moving from the world’s seventh leading cause of death in 2000 to the twenty-first in 2021."<sup id="cite_ref-227" class="reference"><a href="#cite_note-227"><span class="cite-bracket">&#91;</span>227<span class="cite-bracket">&#93;</span></a></sup> </p><p>Among persons living with HIV (PLWH), the largest proportion reside in eastern and southern Africa (20.6 million, 54.6%). This region also had the highest rate of adult and child deaths due to AIDS in 2020 (310,000, 46.6%). Sub-Saharan African adolescent girls and young women (aged 15–24 years) account for 77% of new infections among this age-range globally.<sup id="cite_ref-:0_154-5" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> Here, in contrast to other regions, adolescent girls and young women are three times more likely to acquire HIV than age-matched males.<sup id="cite_ref-:0_154-6" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> Despite these statistics, overall, new HIV infections and AIDS-related deaths have substantially decreased in this region since 2010.<sup id="cite_ref-:2_228-0" class="reference"><a href="#cite_note-:2-228"><span class="cite-bracket">&#91;</span>228<span class="cite-bracket">&#93;</span></a></sup> </p><p>Eastern Europe and central Asia has observed a 43% increase in new HIV infections and 32% increase in AIDS-related deaths since 2010, the highest of all global regions.<sup id="cite_ref-:2_228-1" class="reference"><a href="#cite_note-:2-228"><span class="cite-bracket">&#91;</span>228<span class="cite-bracket">&#93;</span></a></sup> These infections are predominantly distributed in persons who inject drugs, with gay men and other men who have sex with men or persons who engage in transaction sex the second and third populations most impacted in this region.<sup id="cite_ref-:2_228-2" class="reference"><a href="#cite_note-:2-228"><span class="cite-bracket">&#91;</span>228<span class="cite-bracket">&#93;</span></a></sup> </p><p>At the end of 2019, United States indicated that approximately 1.2&#160;million people aged ≥13 years were living with HIV, resulting in about 18,500 deaths in 2020.<sup id="cite_ref-:3_229-0" class="reference"><a href="#cite_note-:3-229"><span class="cite-bracket">&#91;</span>229<span class="cite-bracket">&#93;</span></a></sup> There were 34,800 estimated new infections in the US in 2019, 53% of which were in the southern region of the country.<sup id="cite_ref-:3_229-1" class="reference"><a href="#cite_note-:3-229"><span class="cite-bracket">&#91;</span>229<span class="cite-bracket">&#93;</span></a></sup> In addition to geographic location, significant disparities in HIV incidence exist among men, Black or Hispanic populations, and men who reported male-to-male sexual contact. The US Centers for Disease Control and Prevention estimated that in that year, 158,500 people or 13% of infected Americans were unaware of their infection.<sup id="cite_ref-:3_229-2" class="reference"><a href="#cite_note-:3-229"><span class="cite-bracket">&#91;</span>229<span class="cite-bracket">&#93;</span></a></sup> </p><p>In the <a href="/wiki/HIV/AIDS_in_the_United_Kingdom" title="HIV/AIDS in the United Kingdom">United Kingdom</a> as of 2015<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=HIV/AIDS&amp;action=edit">&#91;update&#93;</a></sup>, there were approximately 101,200 cases which resulted in 594 deaths.<sup id="cite_ref-230" class="reference"><a href="#cite_note-230"><span class="cite-bracket">&#91;</span>230<span class="cite-bracket">&#93;</span></a></sup> In Canada as of 2008, there were about 65,000 cases causing 53 deaths.<sup id="cite_ref-231" class="reference"><a href="#cite_note-231"><span class="cite-bracket">&#91;</span>231<span class="cite-bracket">&#93;</span></a></sup> Between the first recognition of AIDS (in 1981) and 2009, it has led to nearly 30&#160;million deaths.<sup id="cite_ref-TotalDeath2010_232-0" class="reference"><a href="#cite_note-TotalDeath2010-232"><span class="cite-bracket">&#91;</span>232<span class="cite-bracket">&#93;</span></a></sup> Rates of HIV are lowest in North Africa and the Middle East (0.1% or less), <a href="/wiki/East_Asia" title="East Asia">East Asia</a> (0.1%), and Western and Central Europe (0.2%).<sup id="cite_ref-UN2011Fifty_233-0" class="reference"><a href="#cite_note-UN2011Fifty-233"><span class="cite-bracket">&#91;</span>233<span class="cite-bracket">&#93;</span></a></sup> The worst-affected European countries, in 2009 and 2012 estimates, are <a href="/wiki/Russia" title="Russia">Russia</a>, <a href="/wiki/Ukraine" title="Ukraine">Ukraine</a>, <a href="/wiki/Latvia" title="Latvia">Latvia</a>, <a href="/wiki/Moldova" title="Moldova">Moldova</a>, <a href="/wiki/Portugal" title="Portugal">Portugal</a> and <a href="/wiki/Belarus" title="Belarus">Belarus</a>, in decreasing order of prevalence.<sup id="cite_ref-234" class="reference"><a href="#cite_note-234"><span class="cite-bracket">&#91;</span>234<span class="cite-bracket">&#93;</span></a></sup> </p><p>Groups at higher risk of acquiring HIV include persons who engage in <a href="/wiki/Transactional_sex" title="Transactional sex">transactional sex</a>, <a href="/wiki/Gay_men" title="Gay men">gay men</a> and other <a href="/wiki/Men_who_have_sex_with_men" title="Men who have sex with men">men who have sex with men</a>, <a href="/wiki/Drug_injection" title="Drug injection">persons who inject drugs</a>, <a href="/wiki/Transgender" title="Transgender">transgender persons</a>, and those who are <a href="/wiki/Prison" title="Prison">incarcerated</a> or <a href="/wiki/Prison" title="Prison">detained</a>.<sup id="cite_ref-:0_154-7" class="reference"><a href="#cite_note-:0-154"><span class="cite-bracket">&#91;</span>154<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/History_of_HIV/AIDS" title="History of HIV/AIDS">History of HIV/AIDS</a></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">For a chronological guide, see <a href="/wiki/Timeline_of_HIV/AIDS" title="Timeline of HIV/AIDS">Timeline of HIV/AIDS</a>.</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Category:HIV/AIDS_by_country" title="Category:HIV/AIDS by country">Category:HIV/AIDS by country</a></div> <div class="mw-heading mw-heading3"><h3 id="Discovery">Discovery</h3></div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Mmwr-aids-July1981-report-101.png" class="mw-file-description"><img alt="text of the Morbidity and Mortality Weekly Report newsletter" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ed/Mmwr-aids-July1981-report-101.png/220px-Mmwr-aids-July1981-report-101.png" decoding="async" width="220" height="315" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ed/Mmwr-aids-July1981-report-101.png/330px-Mmwr-aids-July1981-report-101.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ed/Mmwr-aids-July1981-report-101.png/440px-Mmwr-aids-July1981-report-101.png 2x" data-file-width="2360" data-file-height="3377" /></a><figcaption>The <i><a href="/wiki/Morbidity_and_Mortality_Weekly_Report" title="Morbidity and Mortality Weekly Report">Morbidity and Mortality Weekly Report</a></i> reported in 1981 on what was later to be called "AIDS".</figcaption></figure> <p>The first news story on the disease appeared on May 18, 1981, in the gay newspaper <i><a href="/wiki/New_York_Native" title="New York Native">New York Native</a></i>.<sup id="cite_ref-235" class="reference"><a href="#cite_note-235"><span class="cite-bracket">&#91;</span>235<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-236" class="reference"><a href="#cite_note-236"><span class="cite-bracket">&#91;</span>236<span class="cite-bracket">&#93;</span></a></sup> AIDS was first clinically reported on June 5, 1981, with five cases in the United States.<sup id="cite_ref-M169_41-4" class="reference"><a href="#cite_note-M169-41"><span class="cite-bracket">&#91;</span>41<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-237" class="reference"><a href="#cite_note-237"><span class="cite-bracket">&#91;</span>237<span class="cite-bracket">&#93;</span></a></sup> The initial cases were a cluster of injecting drug users and gay men with no known cause of impaired immunity who showed symptoms of <i><a href="/wiki/Pneumocystis_carinii" class="mw-redirect" title="Pneumocystis carinii">Pneumocystis carinii</a></i> pneumonia (PCP), a rare opportunistic infection that was known to occur in people with very compromised immune systems.<sup id="cite_ref-MMWR2_238-0" class="reference"><a href="#cite_note-MMWR2-238"><span class="cite-bracket">&#91;</span>238<span class="cite-bracket">&#93;</span></a></sup> Soon thereafter, a large number of homosexual men developed a generally rare skin cancer called <a href="/wiki/Kaposi%27s_sarcoma" title="Kaposi&#39;s sarcoma">Kaposi's sarcoma</a> (KS).<sup id="cite_ref-pmid7287964_239-0" class="reference"><a href="#cite_note-pmid7287964-239"><span class="cite-bracket">&#91;</span>239<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-pmid6116083_240-0" class="reference"><a href="#cite_note-pmid6116083-240"><span class="cite-bracket">&#91;</span>240<span class="cite-bracket">&#93;</span></a></sup> Many more cases of PCP and KS emerged, alerting U.S. Centers for Disease Control and Prevention (CDC) and a CDC task force was formed to monitor the outbreak.<sup id="cite_ref-Basavapathruni_2007_241-0" class="reference"><a href="#cite_note-Basavapathruni_2007-241"><span class="cite-bracket">&#91;</span>241<span class="cite-bracket">&#93;</span></a></sup> </p><p>In the early days, the CDC did not have an official name for the disease, often referring to it by way of diseases associated with it, such as <a href="/wiki/Lymphadenopathy" title="Lymphadenopathy">lymphadenopathy</a>, the disease after which the discoverers of HIV originally named the virus.<sup id="cite_ref-MMWR1982a_242-0" class="reference"><a href="#cite_note-MMWR1982a-242"><span class="cite-bracket">&#91;</span>242<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Montagnier_243-0" class="reference"><a href="#cite_note-Montagnier-243"><span class="cite-bracket">&#91;</span>243<span class="cite-bracket">&#93;</span></a></sup> They also used <i>Kaposi's sarcoma and opportunistic infections</i>, the name by which a task force had been set up in 1981.<sup id="cite_ref-MMWR1982b_244-0" class="reference"><a href="#cite_note-MMWR1982b-244"><span class="cite-bracket">&#91;</span>244<span class="cite-bracket">&#93;</span></a></sup> At one point the CDC referred to it as the "4H disease", as the syndrome seemed to affect heroin users, homosexuals, <a href="/wiki/Hemophilia" class="mw-redirect" title="Hemophilia">hemophiliacs</a>, and <a href="/wiki/Haiti" title="Haiti">Haitians</a>.<sup id="cite_ref-245" class="reference"><a href="#cite_note-245"><span class="cite-bracket">&#91;</span>245<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-SciRep470b_246-0" class="reference"><a href="#cite_note-SciRep470b-246"><span class="cite-bracket">&#91;</span>246<span class="cite-bracket">&#93;</span></a></sup> The term <i>GRID</i>, which stood for <a href="/wiki/Gay-related_immune_deficiency" class="mw-redirect" title="Gay-related immune deficiency">gay-related immune deficiency</a>, had also been coined.<sup id="cite_ref-Altman_247-0" class="reference"><a href="#cite_note-Altman-247"><span class="cite-bracket">&#91;</span>247<span class="cite-bracket">&#93;</span></a></sup> However, after determining that AIDS was not isolated to the <a href="/wiki/Gay_community" class="mw-redirect" title="Gay community">gay community</a>,<sup id="cite_ref-MMWR1982b_244-1" class="reference"><a href="#cite_note-MMWR1982b-244"><span class="cite-bracket">&#91;</span>244<span class="cite-bracket">&#93;</span></a></sup> it was realized that the term <i>GRID</i> was misleading, and the term <i>AIDS</i> was introduced at a meeting in July 1982.<sup id="cite_ref-Kher_248-0" class="reference"><a href="#cite_note-Kher-248"><span class="cite-bracket">&#91;</span>248<span class="cite-bracket">&#93;</span></a></sup> By September 1982 the CDC started referring to the disease as AIDS.<sup id="cite_ref-MMWR1982c_249-0" class="reference"><a href="#cite_note-MMWR1982c-249"><span class="cite-bracket">&#91;</span>249<span class="cite-bracket">&#93;</span></a></sup> </p><p>In 1983, two separate research groups led by <a href="/wiki/Robert_Gallo" title="Robert Gallo">Robert Gallo</a> and <a href="/wiki/Luc_Montagnier" title="Luc Montagnier">Luc Montagnier</a> declared that a novel retrovirus may have been infecting people with AIDS, and published their findings in the same issue of the journal <i><a href="/wiki/Science_(journal)" title="Science (journal)">Science</a></i>.<sup id="cite_ref-Gallo_250-0" class="reference"><a href="#cite_note-Gallo-250"><span class="cite-bracket">&#91;</span>250<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Montagnier_243-1" class="reference"><a href="#cite_note-Montagnier-243"><span class="cite-bracket">&#91;</span>243<span class="cite-bracket">&#93;</span></a></sup> Gallo claimed a virus which his group had isolated from a person with AIDS was strikingly similar in <a href="/wiki/Virus_structure" class="mw-redirect" title="Virus structure">shape</a> to other <a href="/wiki/Human_T-lymphotropic_virus" class="mw-redirect" title="Human T-lymphotropic virus">human T-lymphotropic viruses</a> (HTLVs) that his group had been the first to isolate. Gallo's group called their newly isolated virus HTLV-III. At the same time, Montagnier's group isolated a virus from a person presenting with swelling of the <a href="/wiki/Lymph_node" title="Lymph node">lymph nodes</a> of the neck and <a href="/wiki/Asthenia" class="mw-redirect" title="Asthenia">physical weakness</a>, two characteristic symptoms of AIDS. Contradicting the report from Gallo's group, Montagnier and his colleagues showed that core proteins of this virus were immunologically different from those of HTLV-I. Montagnier's group named their isolated virus lymphadenopathy-associated virus (LAV).<sup id="cite_ref-Basavapathruni_2007_241-1" class="reference"><a href="#cite_note-Basavapathruni_2007-241"><span class="cite-bracket">&#91;</span>241<span class="cite-bracket">&#93;</span></a></sup> As these two viruses turned out to be the same, in 1986, LAV and HTLV-III were renamed HIV.<sup id="cite_ref-251" class="reference"><a href="#cite_note-251"><span class="cite-bracket">&#91;</span>251<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Origins">Origins</h3></div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:SIV_primates.jpg" class="mw-file-description"><img alt="three primates possible sources of HIV" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/93/SIV_primates.jpg/300px-SIV_primates.jpg" decoding="async" width="300" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/93/SIV_primates.jpg/450px-SIV_primates.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/93/SIV_primates.jpg/600px-SIV_primates.jpg 2x" data-file-width="3300" data-file-height="1487" /></a><figcaption>Left to right: the <a href="/wiki/African_green_monkey" class="mw-redirect" title="African green monkey">African green monkey</a> source of <a href="/wiki/Simian_immunodeficiency_virus" title="Simian immunodeficiency virus">SIV</a>, the <a href="/wiki/Sooty_mangabey" title="Sooty mangabey">sooty mangabey</a> source of <a href="/wiki/HIV-2" class="mw-redirect" title="HIV-2">HIV-2</a>, and the <a href="/wiki/Common_chimpanzee" class="mw-redirect" title="Common chimpanzee">chimpanzee</a> source of <a href="/wiki/HIV-1" class="mw-redirect" title="HIV-1">HIV-1</a></figcaption></figure> <p>The origin of HIV / AIDS and the circumstances that led to its emergence remain unsolved.<sup id="cite_ref-Thomas_Gilbert_252-0" class="reference"><a href="#cite_note-Thomas_Gilbert-252"><span class="cite-bracket">&#91;</span>252<span class="cite-bracket">&#93;</span></a></sup> </p><p>Both HIV-1 and HIV-2 are believed to have originated in non-human <a href="/wiki/Primate" title="Primate">primates</a> in West-central Africa and were <a href="/wiki/Zoonosis" title="Zoonosis">transferred to humans</a> in the early 20th century.<sup id="cite_ref-Orgin2011_26-1" class="reference"><a href="#cite_note-Orgin2011-26"><span class="cite-bracket">&#91;</span>26<span class="cite-bracket">&#93;</span></a></sup> HIV-1 appears to have originated in southern <a href="/wiki/Cameroon" title="Cameroon">Cameroon</a> through the evolution of SIV(cpz), a <a href="/wiki/Simian_immunodeficiency_virus" title="Simian immunodeficiency virus">simian immunodeficiency virus</a> (SIV) that infects wild <a href="/wiki/Common_chimpanzee" class="mw-redirect" title="Common chimpanzee">chimpanzees</a> (HIV-1 descends from the SIVcpz endemic in the chimpanzee subspecies <i>Pan troglodytes troglodytes</i>).<sup id="cite_ref-pmid9989410_253-0" class="reference"><a href="#cite_note-pmid9989410-253"><span class="cite-bracket">&#91;</span>253<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Keele_254-0" class="reference"><a href="#cite_note-Keele-254"><span class="cite-bracket">&#91;</span>254<span class="cite-bracket">&#93;</span></a></sup> The closest relative of HIV-2 is SIV (smm), a virus of the <a href="/wiki/Sooty_mangabey" title="Sooty mangabey">sooty mangabey</a> (<i>Cercocebus atys atys</i>), an <a href="/wiki/Old_World_monkey" title="Old World monkey">Old World monkey</a> living in coastal West Africa (from southern <a href="/wiki/Senegal" title="Senegal">Senegal</a> to western <a href="/wiki/Ivory_Coast" title="Ivory Coast">Ivory Coast</a>).<sup id="cite_ref-Reeves_100-1" class="reference"><a href="#cite_note-Reeves-100"><span class="cite-bracket">&#91;</span>100<span class="cite-bracket">&#93;</span></a></sup> <a href="/wiki/New_World_monkey" title="New World monkey">New World monkeys</a> such as the <a href="/wiki/Night_monkey" title="Night monkey">owl monkey</a> are resistant to <a href="/wiki/Subtypes_of_HIV" title="Subtypes of HIV">HIV-1</a> infection, possibly because of a genomic <a href="/wiki/Fusion_gene" title="Fusion gene">fusion</a> of two viral resistance genes.<sup id="cite_ref-Goodier_255-0" class="reference"><a href="#cite_note-Goodier-255"><span class="cite-bracket">&#91;</span>255<span class="cite-bracket">&#93;</span></a></sup> HIV-1 is thought to have jumped the species barrier on at least three separate occasions, giving rise to the three groups of the virus, M, N, and O.<sup id="cite_ref-Sharp2001_256-0" class="reference"><a href="#cite_note-Sharp2001-256"><span class="cite-bracket">&#91;</span>256<span class="cite-bracket">&#93;</span></a></sup> </p><p>There is evidence that humans who participate in <a href="/wiki/Bushmeat" title="Bushmeat">bushmeat</a> activities, either as hunters or as bushmeat vendors, commonly acquire SIV.<sup id="cite_ref-Kalish2005_257-0" class="reference"><a href="#cite_note-Kalish2005-257"><span class="cite-bracket">&#91;</span>257<span class="cite-bracket">&#93;</span></a></sup> However, SIV is a weak virus which is typically suppressed by the human immune system within weeks of infection. It is thought that several transmissions of the virus from individual to individual in quick succession are necessary to allow it enough time to mutate into HIV.<sup id="cite_ref-Marx2001_258-0" class="reference"><a href="#cite_note-Marx2001-258"><span class="cite-bracket">&#91;</span>258<span class="cite-bracket">&#93;</span></a></sup> Furthermore, due to its relatively low person-to-person transmission rate, SIV can only spread throughout the population in the presence of one or more high-risk transmission channels, which are thought to have been absent in Africa before the 20th century.<sup id="cite_ref-259" class="reference"><a href="#cite_note-259"><span class="cite-bracket">&#91;</span>259<span class="cite-bracket">&#93;</span></a></sup> </p><p>Specific proposed high-risk transmission channels, allowing the virus to adapt to humans and spread throughout society, depend on the proposed timing of the animal-to-human crossing. Genetic studies of the virus suggest that the most recent common ancestor of the HIV-1 M group dates back to <abbr title="circa">c.</abbr> 1910.<sup id="cite_ref-Worobey2008_260-0" class="reference"><a href="#cite_note-Worobey2008-260"><span class="cite-bracket">&#91;</span>260<span class="cite-bracket">&#93;</span></a></sup> Proponents of this dating link the HIV epidemic with the emergence of <a href="/wiki/Colonialism" title="Colonialism">colonialism</a> and growth of large colonial African cities, leading to social changes, including a higher degree of sexual promiscuity, the spread of prostitution, and the accompanying high frequency of <a href="/wiki/Genital_ulcer_disease" class="mw-redirect" title="Genital ulcer disease">genital ulcer diseases</a> (such as <a href="/wiki/Syphilis" title="Syphilis">syphilis</a>) in nascent colonial cities.<sup id="cite_ref-Sousa2010_261-0" class="reference"><a href="#cite_note-Sousa2010-261"><span class="cite-bracket">&#91;</span>261<span class="cite-bracket">&#93;</span></a></sup> While transmission rates of HIV during vaginal intercourse are low under regular circumstances, they are increased manyfold if one of the partners has a <a href="/wiki/Sexually_transmitted_disease" class="mw-redirect" title="Sexually transmitted disease">sexually transmitted infection</a> causing genital ulcers. Early 1900s colonial cities were notable for their high prevalence of prostitution and genital ulcers, to the degree that, as of 1928, as many as 45% of female residents of eastern <a href="/wiki/Kinshasa" title="Kinshasa">Kinshasa</a> were thought to have been prostitutes, and, as of 1933, around 15% of all residents of the same city had syphilis.<sup id="cite_ref-Sousa2010_261-1" class="reference"><a href="#cite_note-Sousa2010-261"><span class="cite-bracket">&#91;</span>261<span class="cite-bracket">&#93;</span></a></sup> </p><p>An alternative view holds that unsafe medical practices in Africa after World War II, such as unsterile reuse of single-use syringes during mass vaccination, antibiotic and anti-malaria treatment campaigns, were the initial vector that allowed the virus to adapt to humans and spread.<sup id="cite_ref-Marx2001_258-1" class="reference"><a href="#cite_note-Marx2001-258"><span class="cite-bracket">&#91;</span>258<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Chitnis2000_262-0" class="reference"><a href="#cite_note-Chitnis2000-262"><span class="cite-bracket">&#91;</span>262<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-McNeil_263-0" class="reference"><a href="#cite_note-McNeil-263"><span class="cite-bracket">&#91;</span>263<span class="cite-bracket">&#93;</span></a></sup> </p><p>The earliest well-documented case of HIV in a human dates back to 1959 in the <a href="/wiki/Belgian_Congo" title="Belgian Congo">Congo</a>.<sup id="cite_ref-Zhu_264-0" class="reference"><a href="#cite_note-Zhu-264"><span class="cite-bracket">&#91;</span>264<span class="cite-bracket">&#93;</span></a></sup> The virus may have been present in the U.S. as early as the mid-to-late 1950s, as a sixteen-year-old male named <a href="/wiki/Robert_Rayford" title="Robert Rayford">Robert Rayford</a> presented with symptoms in 1966 and died in 1969. In the 1970s, there were cases of getting parasites and becoming sick with what was called "gay bowel disease", but what is now suspected to have been AIDS.<sup id="cite_ref-265" class="reference"><a href="#cite_note-265"><span class="cite-bracket">&#91;</span>265<span class="cite-bracket">&#93;</span></a></sup> </p><p>The earliest retrospectively described case of AIDS is believed to have been in Norway beginning in 1966, that of <a href="/wiki/Arvid_Noe" title="Arvid Noe">Arvid Noe</a>.<sup id="cite_ref-266" class="reference"><a href="#cite_note-266"><span class="cite-bracket">&#91;</span>266<span class="cite-bracket">&#93;</span></a></sup> In July 1960, in the wake of <a href="/wiki/Democratic_Republic_of_the_Congo#Independence_and_political_crisis_(1960–1965)" title="Democratic Republic of the Congo">Congo's independence</a>, the <a href="/wiki/United_Nations" title="United Nations">United Nations</a> recruited <a href="/wiki/French_language" title="French language">Francophone</a> experts and technicians from all over the world to assist in filling administrative gaps left by <a href="/wiki/Belgium" title="Belgium">Belgium</a>, who did not leave behind an African elite to run the country. By 1962, Haitians made up the second-largest group of well-educated experts (out of the 48 national groups recruited), that totaled around 4,500 in the country.<sup id="cite_ref-267" class="reference"><a href="#cite_note-267"><span class="cite-bracket">&#91;</span>267<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Pépin_268-0" class="reference"><a href="#cite_note-Pépin-268"><span class="cite-bracket">&#91;</span>268<span class="cite-bracket">&#93;</span></a></sup> Dr. Jacques Pépin, a Canadian author of <i>The Origins of AIDS</i>, stipulates that <a href="/wiki/Haiti" title="Haiti">Haiti</a> was one of HIV's entry points to the U.S. and that a Haitian may have carried HIV back across the Atlantic in the 1960s.<sup id="cite_ref-Pépin_268-1" class="reference"><a href="#cite_note-Pépin-268"><span class="cite-bracket">&#91;</span>268<span class="cite-bracket">&#93;</span></a></sup> Although there was known to have been at least one case of AIDS in the U.S. from 1966,<sup id="cite_ref-269" class="reference"><a href="#cite_note-269"><span class="cite-bracket">&#91;</span>269<span class="cite-bracket">&#93;</span></a></sup> the vast majority of infections occurring outside sub-Saharan Africa (including the U.S.) can be traced back to a single unknown individual who became infected with HIV in Haiti and brought the infection to the U.S. at some time around 1969.<sup id="cite_ref-Thomas_Gilbert_252-1" class="reference"><a href="#cite_note-Thomas_Gilbert-252"><span class="cite-bracket">&#91;</span>252<span class="cite-bracket">&#93;</span></a></sup> The epidemic rapidly spread among high-risk groups (initially, sexually promiscuous men who have sex with men). By 1978, the prevalence of HIV-1 among gay male residents of <a href="/wiki/New_York_City" title="New York City">New York City</a> and <a href="/wiki/San_Francisco" title="San Francisco">San Francisco</a> was estimated at 5%, suggesting that several thousand individuals in the country had been infected.<sup id="cite_ref-Thomas_Gilbert_252-2" class="reference"><a href="#cite_note-Thomas_Gilbert-252"><span class="cite-bracket">&#91;</span>252<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2></div> <div class="mw-heading mw-heading3"><h3 id="Stigma">Stigma</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Discrimination_against_people_with_HIV/AIDS" title="Discrimination against people with HIV/AIDS">Discrimination against people with HIV/AIDS</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Ryan_White.jpg" class="mw-file-description"><img alt="A teenage male with the hand of another resting on his left shoulder smiling for the camera" src="//upload.wikimedia.org/wikipedia/commons/9/97/Ryan_White.jpg" decoding="async" width="162" height="216" class="mw-file-element" data-file-width="162" data-file-height="216" /></a><figcaption><a href="/wiki/Ryan_White" title="Ryan White">Ryan White</a> became a <a href="/wiki/Poster_child" title="Poster child">poster child</a> for HIV after being expelled from school because he was infected.<sup id="cite_ref-270" class="reference"><a href="#cite_note-270"><span class="cite-bracket">&#91;</span>270<span class="cite-bracket">&#93;</span></a></sup></figcaption></figure> <p>AIDS stigma exists around the world in a variety of ways, including <a href="/wiki/Shunning" title="Shunning">ostracism</a>, <a href="/wiki/Social_rejection" title="Social rejection">rejection</a>, discrimination and avoidance of HIV-infected people; compulsory HIV testing without prior <a href="/wiki/Consent" title="Consent">consent</a> or protection of <a href="/wiki/Confidentiality" title="Confidentiality">confidentiality</a>; violence against HIV-infected individuals or people who are perceived to be infected with HIV; and the <a href="/wiki/Quarantine" title="Quarantine">quarantine</a> of HIV-infected individuals.<sup id="cite_ref-UNAIDS2006Ch4_22-2" class="reference"><a href="#cite_note-UNAIDS2006Ch4-22"><span class="cite-bracket">&#91;</span>22<span class="cite-bracket">&#93;</span></a></sup> Stigma-related violence or the fear of violence prevents many people from seeking HIV testing, returning for their results, or securing treatment, possibly turning what could be a manageable chronic illness into a death sentence and perpetuating the spread of HIV.<sup id="cite_ref-Ogden_271-0" class="reference"><a href="#cite_note-Ogden-271"><span class="cite-bracket">&#91;</span>271<span class="cite-bracket">&#93;</span></a></sup> </p><p>AIDS stigma has been further divided into the following three categories: </p> <ul><li><i>Instrumental AIDS stigma</i>—a reflection of the fear and apprehension that are likely to be associated with any deadly and transmissible illness.<sup id="cite_ref-Herek1999_272-0" class="reference"><a href="#cite_note-Herek1999-272"><span class="cite-bracket">&#91;</span>272<span class="cite-bracket">&#93;</span></a></sup></li> <li><i>Symbolic AIDS stigma</i>—the use of HIV/AIDS to express attitudes toward the social groups or lifestyles perceived to be associated with the disease.<sup id="cite_ref-Herek1999_272-1" class="reference"><a href="#cite_note-Herek1999-272"><span class="cite-bracket">&#91;</span>272<span class="cite-bracket">&#93;</span></a></sup></li> <li><i>Courtesy AIDS stigma</i>—stigmatization of people connected to the issue of HIV/AIDS or HIV-positive people.<sup id="cite_ref-Snyder_273-0" class="reference"><a href="#cite_note-Snyder-273"><span class="cite-bracket">&#91;</span>273<span class="cite-bracket">&#93;</span></a></sup></li></ul> <p>Often, AIDS stigma is expressed in conjunction with one or more other stigmas, particularly those associated with homosexuality, <a href="/wiki/Bisexuality" title="Bisexuality">bisexuality</a>, <a href="/wiki/Promiscuity" title="Promiscuity">promiscuity</a>, prostitution, and <a href="/wiki/Intravenous_drug_use_(recreational)" class="mw-redirect" title="Intravenous drug use (recreational)">intravenous drug use</a>.<sup id="cite_ref-274" class="reference"><a href="#cite_note-274"><span class="cite-bracket">&#91;</span>274<span class="cite-bracket">&#93;</span></a></sup> </p><p>In many <a href="/wiki/Developed_country" title="Developed country">developed countries</a>, there is an <a href="/wiki/AIDS_and_homosexuality" class="mw-redirect" title="AIDS and homosexuality">association between AIDS and homosexuality or bisexuality</a>, and this association is correlated with higher levels of sexual prejudice, such as <a href="/wiki/Homophobia" title="Homophobia">anti-homosexual</a> or <a href="/wiki/Biphobia" title="Biphobia">anti-bisexual</a> attitudes.<sup id="cite_ref-Herek2002_275-0" class="reference"><a href="#cite_note-Herek2002-275"><span class="cite-bracket">&#91;</span>275<span class="cite-bracket">&#93;</span></a></sup> There is also a perceived association between AIDS and all male-male sexual behavior, including sex between uninfected men.<sup id="cite_ref-Herek1999_272-2" class="reference"><a href="#cite_note-Herek1999-272"><span class="cite-bracket">&#91;</span>272<span class="cite-bracket">&#93;</span></a></sup> However, the dominant mode of spread worldwide for HIV remains heterosexual transmission.<sup id="cite_ref-276" class="reference"><a href="#cite_note-276"><span class="cite-bracket">&#91;</span>276<span class="cite-bracket">&#93;</span></a></sup> </p><p>The <a href="/wiki/NAMES_Project_AIDS_Memorial_Quilt" title="NAMES Project AIDS Memorial Quilt">NAMES Project AIDS Memorial Quilt</a> was conceived in 1985 to celebrate the lives of those who had died of AIDS when stigma prevented many from receiving funerals. It is now cared for by the <a href="/wiki/National_AIDS_Memorial" class="mw-redirect" title="National AIDS Memorial">National AIDS Memorial</a> in San Francisco. </p><p>In 2003, as part of an overall reform of marriage and population legislation, it became legal for those diagnosed with AIDS to marry in China.<sup id="cite_ref-277" class="reference"><a href="#cite_note-277"><span class="cite-bracket">&#91;</span>277<span class="cite-bracket">&#93;</span></a></sup> </p><p>In 2013, the <a href="/wiki/National_Library_of_Medicine" class="mw-redirect" title="National Library of Medicine">U.S. National Library of Medicine</a> developed a traveling exhibition titled <i>Surviving and Thriving: AIDS, Politics, and Culture</i>;<sup id="cite_ref-278" class="reference"><a href="#cite_note-278"><span class="cite-bracket">&#91;</span>278<span class="cite-bracket">&#93;</span></a></sup> this covered medical research, the U.S. government's response, and personal stories from people with AIDS, caregivers, and activists.<sup id="cite_ref-279" class="reference"><a href="#cite_note-279"><span class="cite-bracket">&#91;</span>279<span class="cite-bracket">&#93;</span></a></sup> </p><p>Stigma has proved an obstacle to the update of <a href="/wiki/Pre-exposure_prophylaxis_for_HIV_prevention" title="Pre-exposure prophylaxis for HIV prevention">PrEP</a>. Within the MSM community, the greatest barrier to PrEP use has been the stigma surrounding HIV and gay men. Gay men on PrEP have experienced "<a href="/wiki/Slut-shaming" title="Slut-shaming">slut-shaming</a>".<sup id="cite_ref-280" class="reference"><a href="#cite_note-280"><span class="cite-bracket">&#91;</span>280<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-281" class="reference"><a href="#cite_note-281"><span class="cite-bracket">&#91;</span>281<span class="cite-bracket">&#93;</span></a></sup> Numerous other barriers have been identified, including lack of quality LGBTQ care, cost, and adherence to medication use.<sup id="cite_ref-282" class="reference"><a href="#cite_note-282"><span class="cite-bracket">&#91;</span>282<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Economic_impact">Economic impact</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main articles: <a href="/wiki/Economic_impact_of_HIV/AIDS" title="Economic impact of HIV/AIDS">Economic impact of HIV/AIDS</a> and <a href="/wiki/Cost_of_HIV_treatment" title="Cost of HIV treatment">Cost of HIV treatment</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Life_expectancy_in_select_Southern_African_countries_1960-2012.svg" class="mw-file-description"><img alt="A graph showing several increasing lines followed by a sharp fall of the lines starting in the mid-1980s to 1990s" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d4/Life_expectancy_in_select_Southern_African_countries_1960-2012.svg/330px-Life_expectancy_in_select_Southern_African_countries_1960-2012.svg.png" decoding="async" width="330" height="216" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d4/Life_expectancy_in_select_Southern_African_countries_1960-2012.svg/495px-Life_expectancy_in_select_Southern_African_countries_1960-2012.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d4/Life_expectancy_in_select_Southern_African_countries_1960-2012.svg/660px-Life_expectancy_in_select_Southern_African_countries_1960-2012.svg.png 2x" data-file-width="512" data-file-height="335" /></a><figcaption>Changes in life expectancy in some African countries, 1960–2012</figcaption></figure> <p>HIV/AIDS affects the economics of both individuals and countries.<sup id="cite_ref-M117_283-0" class="reference"><a href="#cite_note-M117-283"><span class="cite-bracket">&#91;</span>283<span class="cite-bracket">&#93;</span></a></sup> The <a href="/wiki/Gross_domestic_product" title="Gross domestic product">gross domestic product</a> of the most affected countries has decreased due to the lack of <a href="/wiki/Human_capital" title="Human capital">human capital</a>.<sup id="cite_ref-M117_283-1" class="reference"><a href="#cite_note-M117-283"><span class="cite-bracket">&#91;</span>283<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Bell-et-al-2003_284-0" class="reference"><a href="#cite_note-Bell-et-al-2003-284"><span class="cite-bracket">&#91;</span>284<span class="cite-bracket">&#93;</span></a></sup> Without proper nutrition, health care and medicine, large numbers of people die from AIDS-related complications. Before death they will not only be unable to work, but will also require significant medical care. It is estimated that as of 2007 there were 12&#160;million <a href="/wiki/AIDS_orphan" title="AIDS orphan">AIDS orphans</a>.<sup id="cite_ref-M117_283-2" class="reference"><a href="#cite_note-M117-283"><span class="cite-bracket">&#91;</span>283<span class="cite-bracket">&#93;</span></a></sup> Many are cared for by elderly grandparents.<sup id="cite_ref-Greener_285-0" class="reference"><a href="#cite_note-Greener-285"><span class="cite-bracket">&#91;</span>285<span class="cite-bracket">&#93;</span></a></sup> </p><p>Returning to work after beginning treatment for HIV/AIDS is difficult, and affected people often work less than the average worker. <a href="/wiki/Unemployment" title="Unemployment">Unemployment</a> in people with HIV/AIDS also is associated with <a href="/wiki/Suicidal_ideation" title="Suicidal ideation">suicidal ideation</a>, memory problems, and social isolation. Employment increases <a href="/wiki/Self-esteem" title="Self-esteem">self-esteem</a>, sense of dignity, confidence, and <a href="/wiki/Quality_of_life" title="Quality of life">quality of life</a> for people with HIV/AIDS. Anti-retroviral treatment may help people with HIV/AIDS work more, and may increase the chance that a person with HIV/AIDS will be employed (low-quality evidence).<sup id="cite_ref-286" class="reference"><a href="#cite_note-286"><span class="cite-bracket">&#91;</span>286<span class="cite-bracket">&#93;</span></a></sup> </p><p>By affecting mainly young adults, AIDS reduces the taxable population, in turn reducing the resources available for <a href="/wiki/Government_spending" title="Government spending">public expenditures</a> such as education and health services not related to AIDS, resulting in increasing pressure on the state's finances and slower growth of the economy. This causes a slower growth of the tax base, an effect that is reinforced if there are growing expenditures on treating the sick, training (to replace sick workers), sick pay, and caring for AIDS orphans. This is especially true if the sharp increase in adult mortality shifts the responsibility from the family to the government in caring for these orphans.<sup id="cite_ref-Greener_285-1" class="reference"><a href="#cite_note-Greener-285"><span class="cite-bracket">&#91;</span>285<span class="cite-bracket">&#93;</span></a></sup> </p><p>At the household level, AIDS causes both loss of income and increased spending on healthcare. A study in <a href="/wiki/C%C3%B4te_d%27Ivoire" class="mw-redirect" title="Côte d&#39;Ivoire">Côte d'Ivoire</a> showed that households having a person with HIV/AIDS spent twice as much on medical expenses as other households. This additional expenditure also leaves less income to spend on education and other personal or family investment.<sup id="cite_ref-WBank_287-0" class="reference"><a href="#cite_note-WBank-287"><span class="cite-bracket">&#91;</span>287<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Religion_and_AIDS">Religion and AIDS</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Religion_and_HIV/AIDS" title="Religion and HIV/AIDS">Religion and HIV/AIDS</a></div> <p>The topic of religion and AIDS has become highly controversial, primarily because some religious authorities have publicly declared their opposition to the use of condoms.<sup id="cite_ref-288" class="reference"><a href="#cite_note-288"><span class="cite-bracket">&#91;</span>288<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-Thirty_years_after_AIDS_discovery,_appreciation_growing_for_Catholic_approach_289-0" class="reference"><a href="#cite_note-Thirty_years_after_AIDS_discovery,_appreciation_growing_for_Catholic_approach-289"><span class="cite-bracket">&#91;</span>289<span class="cite-bracket">&#93;</span></a></sup> The religious approach to prevent the spread of AIDS, according to a report by American health expert Matthew Hanley titled <i>The Catholic Church and the Global AIDS Crisis</i>, argues that cultural changes are needed, including a re-emphasis on fidelity within marriage and sexual abstinence outside of it.<sup id="cite_ref-Thirty_years_after_AIDS_discovery,_appreciation_growing_for_Catholic_approach_289-1" class="reference"><a href="#cite_note-Thirty_years_after_AIDS_discovery,_appreciation_growing_for_Catholic_approach-289"><span class="cite-bracket">&#91;</span>289<span class="cite-bracket">&#93;</span></a></sup> </p><p>Some religious organizations have claimed that prayer can cure HIV/AIDS. In 2011, the BBC reported that some churches in London were claiming that prayer would cure AIDS, and the <a href="/wiki/London_Borough_of_Hackney" title="London Borough of Hackney">Hackney</a>-based Centre for the Study of Sexual Health and HIV reported that several people stopped taking their medication, sometimes on the direct advice of their pastor, leading to many deaths.<sup id="cite_ref-BBC18102011_290-0" class="reference"><a href="#cite_note-BBC18102011-290"><span class="cite-bracket">&#91;</span>290<span class="cite-bracket">&#93;</span></a></sup> The <a href="/wiki/Synagogue_Church_Of_All_Nations" class="mw-redirect" title="Synagogue Church Of All Nations">Synagogue Church Of All Nations</a> advertised an "anointing water" to promote God's healing, although the group denies advising people to stop taking medication.<sup id="cite_ref-BBC18102011_290-1" class="reference"><a href="#cite_note-BBC18102011-290"><span class="cite-bracket">&#91;</span>290<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Media_portrayal">Media portrayal</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Media_portrayal_of_HIV/AIDS" title="Media portrayal of HIV/AIDS">Media portrayal of HIV/AIDS</a></div> <p>One of the first high-profile cases of AIDS was the American gay actor <a href="/wiki/Rock_Hudson" title="Rock Hudson">Rock Hudson</a>. He had been diagnosed during 1984, announced that he had had the virus on July 25, 1985, and died a few months later on October 2, 1985.<sup id="cite_ref-autogenerated4_291-0" class="reference"><a href="#cite_note-autogenerated4-291"><span class="cite-bracket">&#91;</span>291<span class="cite-bracket">&#93;</span></a></sup> Another notable British casualty of AIDS that year was <a href="/wiki/Nicholas_Eden,_2nd_Earl_of_Avon" title="Nicholas Eden, 2nd Earl of Avon">Nicholas Eden</a>, a gay politician and son of former prime minister <a href="/wiki/Anthony_Eden" title="Anthony Eden">Anthony Eden</a>.<sup id="cite_ref-292" class="reference"><a href="#cite_note-292"><span class="cite-bracket">&#91;</span>292<span class="cite-bracket">&#93;</span></a></sup> On November 24, 1991, British rock star <a href="/wiki/Freddie_Mercury" title="Freddie Mercury">Freddie Mercury</a> died from an AIDS-related illness, having revealed the diagnosis only on the previous day.<sup id="cite_ref-293" class="reference"><a href="#cite_note-293"><span class="cite-bracket">&#91;</span>293<span class="cite-bracket">&#93;</span></a></sup> </p><p>One of the first high-profile heterosexual cases of the virus was American tennis player <a href="/wiki/Arthur_Ashe" title="Arthur Ashe">Arthur Ashe</a>. He was diagnosed as HIV-positive on August 31, 1988, having contracted the virus from blood transfusions during heart surgery earlier in the 1980s. Further tests within 24 hours of the initial diagnosis revealed that Ashe had AIDS, but he did not tell the public about his diagnosis until April 1992.<sup id="cite_ref-294" class="reference"><a href="#cite_note-294"><span class="cite-bracket">&#91;</span>294<span class="cite-bracket">&#93;</span></a></sup> He died as a result on February 6, 1993, aged 49.<sup id="cite_ref-295" class="reference"><a href="#cite_note-295"><span class="cite-bracket">&#91;</span>295<span class="cite-bracket">&#93;</span></a></sup> </p><p>Therese Frare's photograph of gay activist <a href="/wiki/David_Kirby_(activist)" title="David Kirby (activist)">David Kirby</a>, as he lay dying from AIDS while surrounded by family, was taken in April 1990. <i><a href="/wiki/Life_(magazine)" title="Life (magazine)">Life</a></i> magazine said the photo became the one image "most powerfully identified with the HIV/AIDS epidemic." The photo was displayed in <i>Life</i>, was the winner of the <a href="/wiki/World_Press_Photo" title="World Press Photo">World Press Photo</a>, and acquired worldwide notoriety after being used in a <a href="/wiki/United_Colors_of_Benetton" class="mw-redirect" title="United Colors of Benetton">United Colors of Benetton</a> advertising campaign in 1992.<sup id="cite_ref-296" class="reference"><a href="#cite_note-296"><span class="cite-bracket">&#91;</span>296<span class="cite-bracket">&#93;</span></a></sup> </p><p>Many famous artists and AIDS activists such as <a href="/wiki/Larry_Kramer" title="Larry Kramer">Larry Kramer</a>, <a href="/wiki/Diamanda_Gal%C3%A1s" title="Diamanda Galás">Diamanda Galás</a> and <a href="/wiki/Rosa_von_Praunheim" title="Rosa von Praunheim">Rosa von Praunheim</a><sup id="cite_ref-DeutscheWelle_297-0" class="reference"><a href="#cite_note-DeutscheWelle-297"><span class="cite-bracket">&#91;</span>297<span class="cite-bracket">&#93;</span></a></sup> campaign for AIDS education and the rights of those affected. These artists worked with various media formats. </p> <div class="mw-heading mw-heading3"><h3 id="Criminal_transmission">Criminal transmission</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Criminal_transmission_of_HIV" title="Criminal transmission of HIV">Criminal transmission of HIV</a></div> <p>Criminal transmission of HIV is the <a href="/wiki/Intention_(criminal_law)" title="Intention (criminal law)">intentional</a> or <a href="/wiki/Recklessness_(law)" title="Recklessness (law)">reckless</a> infection of a person with the <a href="/wiki/Human_immunodeficiency_virus" class="mw-redirect" title="Human immunodeficiency virus">human immunodeficiency virus</a> (HIV). Some countries or jurisdictions, including some areas of the United States, have laws that criminalize HIV transmission or exposure.<sup id="cite_ref-298" class="reference"><a href="#cite_note-298"><span class="cite-bracket">&#91;</span>298<span class="cite-bracket">&#93;</span></a></sup> Others may charge the accused under laws enacted before the HIV pandemic. </p><p>In 1996, Ugandan-born Canadian <a href="/wiki/Johnson_Aziga" title="Johnson Aziga">Johnson Aziga</a> was diagnosed with HIV; he subsequently had unprotected sex with eleven women without disclosing his diagnosis. By 2003, seven had contracted HIV; two died from complications related to AIDS.<sup id="cite_ref-299" class="reference"><a href="#cite_note-299"><span class="cite-bracket">&#91;</span>299<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-300" class="reference"><a href="#cite_note-300"><span class="cite-bracket">&#91;</span>300<span class="cite-bracket">&#93;</span></a></sup> Aziga was convicted of <a href="/wiki/First-degree_murder" class="mw-redirect" title="First-degree murder">first-degree murder</a> and sentenced to <a href="/wiki/Life_imprisonment_in_Canada" title="Life imprisonment in Canada">life imprisonment</a>.<sup id="cite_ref-301" class="reference"><a href="#cite_note-301"><span class="cite-bracket">&#91;</span>301<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Misconceptions">Misconceptions</h3></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main articles: <a href="/wiki/Misconceptions_about_HIV/AIDS" title="Misconceptions about HIV/AIDS">Misconceptions about HIV/AIDS</a> and <a href="/wiki/Discredited_HIV/AIDS_origins_theories" title="Discredited HIV/AIDS origins theories">Discredited HIV/AIDS origins theories</a></div> <p>There are many <a href="/wiki/Misconceptions_about_HIV_and_AIDS" class="mw-redirect" title="Misconceptions about HIV and AIDS">misconceptions about HIV and AIDS</a>. Three misconceptions are that AIDS can spread through casual contact, that <a href="/wiki/Virgin_cleansing_myth" title="Virgin cleansing myth">sexual intercourse with a virgin</a> will cure AIDS,<sup id="cite_ref-302" class="reference"><a href="#cite_note-302"><span class="cite-bracket">&#91;</span>302<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-303" class="reference"><a href="#cite_note-303"><span class="cite-bracket">&#91;</span>303<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-304" class="reference"><a href="#cite_note-304"><span class="cite-bracket">&#91;</span>304<span class="cite-bracket">&#93;</span></a></sup> and that HIV can infect only gay men and drug users.<sup id="cite_ref-WIFANG_305-0" class="reference"><a href="#cite_note-WIFANG-305"><span class="cite-bracket">&#91;</span>305<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-RASEFSS_306-0" class="reference"><a href="#cite_note-RASEFSS-306"><span class="cite-bracket">&#91;</span>306<span class="cite-bracket">&#93;</span></a></sup> In 2014, some among the British public wrongly thought one could get HIV from kissing (16%), sharing a glass (5%), spitting (16%), a public toilet seat (4%), and coughing or sneezing (5%).<sup id="cite_ref-307" class="reference"><a href="#cite_note-307"><span class="cite-bracket">&#91;</span>307<span class="cite-bracket">&#93;</span></a></sup> Other misconceptions are that any act of anal intercourse between two uninfected gay men can lead to HIV infection, and that open discussion of HIV and homosexuality in schools will lead to increased rates of AIDS.<sup id="cite_ref-308" class="reference"><a href="#cite_note-308"><span class="cite-bracket">&#91;</span>308<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-309" class="reference"><a href="#cite_note-309"><span class="cite-bracket">&#91;</span>309<span class="cite-bracket">&#93;</span></a></sup> </p><p>A small group of individuals continue to dispute the connection between HIV and AIDS,<sup id="cite_ref-Duesberg_310-0" class="reference"><a href="#cite_note-Duesberg-310"><span class="cite-bracket">&#91;</span>310<span class="cite-bracket">&#93;</span></a></sup> the existence of HIV itself, or the validity of HIV testing and treatment methods.<sup id="cite_ref-Kalichman_311-0" class="reference"><a href="#cite_note-Kalichman-311"><span class="cite-bracket">&#91;</span>311<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-SmithNovella_312-0" class="reference"><a href="#cite_note-SmithNovella-312"><span class="cite-bracket">&#91;</span>312<span class="cite-bracket">&#93;</span></a></sup> These claims, known as <a href="/wiki/AIDS_denialism" class="mw-redirect" title="AIDS denialism">AIDS denialism</a>, have been examined and rejected by the scientific community.<sup id="cite_ref-consensus_313-0" class="reference"><a href="#cite_note-consensus-313"><span class="cite-bracket">&#91;</span>313<span class="cite-bracket">&#93;</span></a></sup> However, they have had a significant political impact, particularly <a href="/wiki/HIV/AIDS_denialism_in_South_Africa" title="HIV/AIDS denialism in South Africa">in South Africa</a>, where the government's official embrace of AIDS denialism (1999–2005) was responsible for its ineffective response to that country's AIDS epidemic, and has been blamed for hundreds of thousands of avoidable deaths and HIV infections.<sup id="cite_ref-314" class="reference"><a href="#cite_note-314"><span class="cite-bracket">&#91;</span>314<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-315" class="reference"><a href="#cite_note-315"><span class="cite-bracket">&#91;</span>315<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-316" class="reference"><a href="#cite_note-316"><span class="cite-bracket">&#91;</span>316<span class="cite-bracket">&#93;</span></a></sup> </p><p>Several discredited <a href="/wiki/Conspiracy_theories" class="mw-redirect" title="Conspiracy theories">conspiracy theories</a> have held that HIV was created by scientists, either inadvertently or deliberately. <a href="/wiki/Operation_INFEKTION" class="mw-redirect" title="Operation INFEKTION">Operation INFEKTION</a> was a worldwide Soviet <a href="/wiki/Active_measures" title="Active measures">active measures</a> operation to spread the claim that the United States had created HIV/AIDS. Surveys show that a significant number of people believed—and continue to believe—in such claims.<sup id="cite_ref-infektion_317-0" class="reference"><a href="#cite_note-infektion-317"><span class="cite-bracket">&#91;</span>317<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/HIV/AIDS_research" title="HIV/AIDS research">HIV/AIDS research</a></div> <p>HIV/AIDS research includes all <a href="/wiki/Medical_research" title="Medical research">medical research</a> which attempts to prevent, treat, or cure HIV/AIDS, along with fundamental research about the nature of HIV as an infectious agent, and about AIDS as the disease caused by HIV. </p><p>Many governments and research institutions participate in HIV/AIDS research. This research includes behavioral <a href="/wiki/Health_interventions" class="mw-redirect" title="Health interventions">health interventions</a> such as <a href="/wiki/Sex_education" title="Sex education">sex education</a>, and <a href="/wiki/Drug_development" title="Drug development">drug development</a>, such as research into <a href="/wiki/Microbicides_for_sexually_transmitted_diseases" class="mw-redirect" title="Microbicides for sexually transmitted diseases">microbicides for sexually transmitted diseases</a>, <a href="/wiki/HIV_vaccines" class="mw-redirect" title="HIV vaccines">HIV vaccines</a>, and <a href="/wiki/Antiretroviral_drugs" class="mw-redirect" title="Antiretroviral drugs">antiretroviral drugs</a>. Other medical research areas include the topics of <a href="/wiki/Pre-exposure_prophylaxis" title="Pre-exposure prophylaxis">pre-exposure prophylaxis</a>, <a href="/wiki/Post-exposure_prophylaxis" title="Post-exposure prophylaxis">post-exposure prophylaxis</a>, and <a href="/wiki/Circumcision_and_HIV" title="Circumcision and HIV">circumcision and HIV</a>. Public health officials, researchers, and programs can gain a more comprehensive picture of the barriers they face, and the efficacy of current approaches to HIV treatment and prevention, by tracking standard HIV indicators.<sup id="cite_ref-318" class="reference"><a href="#cite_note-318"><span class="cite-bracket">&#91;</span>318<span class="cite-bracket">&#93;</span></a></sup> Use of common indicators is an increasing focus of development organizations and researchers.<sup id="cite_ref-319" class="reference"><a href="#cite_note-319"><span class="cite-bracket">&#91;</span>319<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-320" class="reference"><a href="#cite_note-320"><span class="cite-bracket">&#91;</span>320<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-AIDS2010GOV-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-AIDS2010GOV_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AIDS2010GOV_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-AIDS2010GOV_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-AIDS2010GOV_1-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20190922044900/https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids">"What Are HIV and AIDS?"</a>. <i>HIV.gov</i>. May 15, 2017. Archived from <a rel="nofollow" class="external text" href="https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids">the original</a> on September 22, 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">September 10,</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=HIV.gov&amp;rft.atitle=What+Are+HIV+and+AIDS%3F&amp;rft.date=2017-05-15&amp;rft_id=https%3A%2F%2Fwww.hiv.gov%2Fhiv-basics%2Foverview%2Fabout-hiv-and-aids%2Fwhat-are-hiv-and-aids&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-AETC-staging-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-AETC-staging_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20171018065658/https://aidsetc.org/guide/hiv-classification-cdc-and-who-staging-systems">"HIV Classification: CDC and WHO Staging Systems"</a>. <i>AIDS Education &amp; Training Center Program</i>. Archived from <a rel="nofollow" class="external text" href="https://aidsetc.org/guide/hiv-classification-cdc-and-who-staging-systems">the original</a> on October 18, 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">September 10,</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=AIDS+Education+%26+Training+Center+Program&amp;rft.atitle=HIV+Classification%3A+CDC+and+WHO+Staging+Systems&amp;rft_id=https%3A%2F%2Faidsetc.org%2Fguide%2Fhiv-classification-cdc-and-who-staging-systems&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.unaids.org/en/resources/presscentre/featurestories/2006/november/20061130redribbonen">"Wear your red ribbon this World AIDS Day"</a>. <i><a href="/wiki/UNAIDS" class="mw-redirect" title="UNAIDS">UNAIDS</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170910221331/http://www.unaids.org/en/resources/presscentre/featurestories/2006/november/20061130redribbonen">Archived</a> from the original on September 10, 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">September 10,</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=UNAIDS&amp;rft.atitle=Wear+your+red+ribbon+this+World+AIDS+Day&amp;rft_id=http%3A%2F%2Fwww.unaids.org%2Fen%2Fresources%2Fpresscentre%2Ffeaturestories%2F2006%2Fnovember%2F20061130redribbonen&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-WHO2015Fact-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-WHO2015Fact_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-WHO2015Fact_4-11"><sup><i><b>l</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.who.int/mediacentre/factsheets/fs360/en/">"HIV/AIDS Fact sheet N°360"</a>. <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a>. November 2015. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160217160830/http://www.who.int/mediacentre/factsheets/fs360/en/">Archived</a> from the original on February 17, 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">February 11,</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=HIV%2FAIDS+Fact+sheet+N%C2%B0360&amp;rft.pub=World+Health+Organization&amp;rft.date=2015-11&amp;rft_id=https%3A%2F%2Fwww.who.int%2Fmediacentre%2Ffactsheets%2Ffs360%2Fen%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-WHO2024Factsheet-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-WHO2024Factsheet_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-WHO2024Factsheet_5-13"><sup><i><b>n</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.who.int/en/news-room/fact-sheets/detail/hiv-aids">"HIV and AIDS"</a>. <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a>. 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Archived from <a rel="nofollow" class="external text" href="http://data.unaids.org/pub/EPISlides/2007/2007_epiupdate_en.pdf">the original</a> <span class="cs1-format">(PDF)</span> on May 27, 2008<span class="reference-accessdate">. Retrieved <span class="nowrap">March 12,</span> 2008</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=2007+AIDS+epidemic+update&amp;rft.date=2007-12&amp;rft.au=UNAIDS&amp;rft.au=World+Health+Organization&amp;rft_id=http%3A%2F%2Fdata.unaids.org%2Fpub%2FEPISlides%2F2007%2F2007_epiupdate_en.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-UN2022-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-UN2022_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-UN2022_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-UN2022_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-UN2022_7-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-UN2022_7-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-UN2022_7-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.unaids.org/en/resources/fact-sheet">"Global HIV &amp; AIDS statistics — 2022 fact sheet"</a>. <i><a href="/wiki/UNAIDS" class="mw-redirect" title="UNAIDS">UNAIDS</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20191204021652/https://www.unaids.org/en/resources/fact-sheet">Archived</a> from the original on December 4, 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">July 20,</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=UNAIDS&amp;rft.atitle=Global+HIV+%26+AIDS+statistics+%E2%80%94+2022+fact+sheet&amp;rft_id=https%3A%2F%2Fwww.unaids.org%2Fen%2Fresources%2Ffact-sheet&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-pmid11396444-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11396444_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSepkowitz2001" class="citation journal cs1">Sepkowitz KA (June 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJM200106073442306">"AIDS – the first 20 years"</a>. <i><a href="/wiki/The_New_England_Journal_of_Medicine" title="The New England Journal of Medicine">The New England Journal of Medicine</a></i>. <b>344</b> (23): 1764–72. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJM200106073442306">10.1056/NEJM200106073442306</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a>&#160;<a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0028-4793">0028-4793</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11396444">11396444</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+New+England+Journal+of+Medicine&amp;rft.atitle=AIDS+%E2%80%93+the+first+20+years&amp;rft.volume=344&amp;rft.issue=23&amp;rft.pages=1764-72&amp;rft.date=2001-06&amp;rft.issn=0028-4793&amp;rft_id=info%3Apmid%2F11396444&amp;rft_id=info%3Adoi%2F10.1056%2FNEJM200106073442306&amp;rft.aulast=Sepkowitz&amp;rft.aufirst=KA&amp;rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252FNEJM200106073442306&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKrämerKretzschmarKrickeberg2010" class="citation book cs1">Krämer A, Kretzschmar M, Krickeberg K (2010). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=Di0_5x82HykC&amp;pg=PA88"><i>Modern infectious disease epidemiology concepts, methods, mathematical models, and public health</i></a> (Online-Ausg.&#160;ed.). New York: Springer. p.&#160;88. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-387-93835-6" title="Special:BookSources/978-0-387-93835-6"><bdi>978-0-387-93835-6</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150924081609/https://books.google.com/books?id=Di0_5x82HykC&amp;pg=PA88">Archived</a> from the original on September 24, 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">June 27,</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Modern+infectious+disease+epidemiology+concepts%2C+methods%2C+mathematical+models%2C+and+public+health&amp;rft.place=New+York&amp;rft.pages=88&amp;rft.edition=Online-Ausg.&amp;rft.pub=Springer&amp;rft.date=2010&amp;rft.isbn=978-0-387-93835-6&amp;rft.aulast=Kr%C3%A4mer&amp;rft.aufirst=Alexander&amp;rft.au=Kretzschmar%2C+Mirjam&amp;rft.au=Krickeberg%2C+Klaus&amp;rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DDi0_5x82HykC%26pg%3DPA88&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKirch2008" class="citation book cs1">Kirch W (2008). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=eSPK7-CHw7oC&amp;pg=PA676"><i>Encyclopedia of Public Health</i></a>. New York: Springer. pp.&#160;676–77. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-1-4020-5613-0" title="Special:BookSources/978-1-4020-5613-0"><bdi>978-1-4020-5613-0</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150911141720/https://books.google.com/books?id=eSPK7-CHw7oC&amp;pg=PA676">Archived</a> from the original on September 11, 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">June 27,</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Encyclopedia+of+Public+Health&amp;rft.place=New+York&amp;rft.pages=676-77&amp;rft.pub=Springer&amp;rft.date=2008&amp;rft.isbn=978-1-4020-5613-0&amp;rft.aulast=Kirch&amp;rft.aufirst=Wilhelm&amp;rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DeSPK7-CHw7oC%26pg%3DPA676&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20191228142824/https://aidsinfo.nih.gov/understanding-hiv-aids/glossary/634/retrovirus">"Retrovirus Definition"</a>. <i>AIDSinfo</i>. Archived from <a rel="nofollow" class="external text" href="https://aidsinfo.nih.gov/understanding-hiv-aids/glossary/634/retrovirus">the original</a> on December 28, 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">December 28,</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=AIDSinfo&amp;rft.atitle=Retrovirus+Definition&amp;rft_id=https%3A%2F%2Faidsinfo.nih.gov%2Funderstanding-hiv-aids%2Fglossary%2F634%2Fretrovirus&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-UN2012Vac-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-UN2012Vac_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-UN2012Vac_12-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-UN2012Vac_12-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFUNAIDS2012" class="citation news cs1">UNAIDS (May 18, 2012). <a rel="nofollow" class="external text" href="http://www.unaids.org/en/resources/presscentre/featurestories/2012/may/20120518vaccinesday/">"The quest for an HIV vaccine"</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20120524051113/http://www.unaids.org/en/resources/presscentre/featurestories/2012/may/20120518vaccinesday/">Archived</a> from the original on May 24, 2012.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.atitle=The+quest+for+an+HIV+vaccine&amp;rft.date=2012-05-18&amp;rft.au=UNAIDS&amp;rft_id=http%3A%2F%2Fwww.unaids.org%2Fen%2Fresources%2Fpresscentre%2Ffeaturestories%2F2012%2Fmay%2F20120518vaccinesday%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-CDC21015Bas-13"><span class="mw-cite-backlink">^ <a href="#cite_ref-CDC21015Bas_13-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-CDC21015Bas_13-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-CDC21015Bas_13-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-CDC21015Bas_13-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cdc.gov/hiv/basics/whatishiv.html">"About HIV/AIDS"</a>. <i>U.S. <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a> (CDC)</i>. December 6, 2015. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160224101946/http://www.cdc.gov/hiv/basics/whatishiv.html">Archived</a> from the original on February 24, 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">February 11,</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=U.S.+Centers+for+Disease+Control+and+Prevention+%28CDC%29&amp;rft.atitle=About+HIV%2FAIDS&amp;rft.date=2015-12-06&amp;rft_id=https%3A%2F%2Fwww.cdc.gov%2Fhiv%2Fbasics%2Fwhatishiv.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-WHO2015Tx-14"><span class="mw-cite-backlink">^ <a href="#cite_ref-WHO2015Tx_14-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-WHO2015Tx_14-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="http://apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1"><i>Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV</i></a> <span class="cs1-format">(PDF)</span>. World Health Organization. 2015. p.&#160;13. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-92-4-150956-5" title="Special:BookSources/978-92-4-150956-5"><bdi>978-92-4-150956-5</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20151014071803/http://apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1">Archived</a> <span class="cs1-format">(PDF)</span> from the original on October 14, 2015.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Guideline+on+when+to+start+antiretroviral+therapy+and+on+pre-exposure+prophylaxis+for+HIV&amp;rft.pages=13&amp;rft.pub=World+Health+Organization&amp;rft.date=2015&amp;rft.isbn=978-92-4-150956-5&amp;rft_id=http%3A%2F%2Fapps.who.int%2Firis%2Fbitstream%2F10665%2F186275%2F1%2F9789241509565_eng.pdf%3Fua%3D1&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-CDCUndetectable-15"><span class="mw-cite-backlink">^ <a href="#cite_ref-CDCUndetectable_15-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-CDCUndetectable_15-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMcCrayMermin2017" class="citation web cs1">McCray E, Mermin J (September 27, 2017). <a rel="nofollow" class="external text" href="https://www.cdc.gov/hiv/library/dcl/dcl/092717.html">"Dear Colleague: September 27, 2017"</a>. U.S. <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a> (CDC). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180130231157/https://www.cdc.gov/hiv/library/dcl/dcl/092717.html">Archived</a> from the original on January 30, 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">February 1,</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Dear+Colleague%3A+September+27%2C+2017&amp;rft.pub=U.S.+Centers+for+Disease+Control+and+Prevention+%28CDC%29&amp;rft.date=2017-09-27&amp;rft.aulast=McCray&amp;rft.aufirst=Eugene&amp;rft.au=Mermin%2C+Jonathan&amp;rft_id=https%3A%2F%2Fwww.cdc.gov%2Fhiv%2Flibrary%2Fdcl%2Fdcl%2F092717.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-Risk_of_sexual_transmission_of_huma-16"><span class="mw-cite-backlink">^ <a href="#cite_ref-Risk_of_sexual_transmission_of_huma_16-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Risk_of_sexual_transmission_of_huma_16-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLeMessurierTraversyVarsaneuxWeekes2018" class="citation journal cs1">LeMessurier J, Traversy G, Varsaneux O, Weekes M, Avey MT, Niragira O, et&#160;al. 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Retrieved <span class="nowrap">August 26,</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=UNAIDS&amp;rft.atitle=Undetectable+%3D+untransmittable&amp;rft_id=https%3A%2F%2Fwww.unaids.org%2Fen%2Fresources%2Fpresscentre%2Ffeaturestories%2F2018%2Fjuly%2Fundetectable-untransmittable&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-TransmissionM2007-18"><span class="mw-cite-backlink">^ <a href="#cite_ref-TransmissionM2007_18-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-TransmissionM2007_18-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRomMarkowitz2007" class="citation book cs1">Rom WN, Markowitz SB, eds. 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title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Journal+of+Internal+Medicine&amp;rft.atitle=The+first+postmodern+pandemic%3A+25+years+of+HIV%2FAIDS&amp;rft.volume=263&amp;rft.issue=3&amp;rft.pages=218-43&amp;rft.date=2008-03&amp;rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A205339589%23id-name%3DS2CID&amp;rft_id=info%3Apmid%2F18205765&amp;rft_id=info%3Adoi%2F10.1111%2Fj.1365-2796.2007.01910.x&amp;rft.aulast=Kallings&amp;rft.aufirst=LO&amp;rft_id=https%3A%2F%2Fdoi.org%2F10.1111%252Fj.1365-2796.2007.01910.x&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span>(subscription required)</span> </li> <li id="cite_note-28"><span class="mw-cite-backlink"><b><a href="#cite_ref-28">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.nih.gov/news-events/news-releases/nih-launches-new-collaboration-develop-gene-based-cures-sickle-cell-disease-hiv-global-scale">"NIH launches new collaboration to develop gene-based cures for sickle cell disease and HIV on global scale"</a>. <i>National Institutes of Health (NIH)</i>. October 23, 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210904180604/https://www.nih.gov/news-events/news-releases/nih-launches-new-collaboration-develop-gene-based-cures-sickle-cell-disease-hiv-global-scale">Archived</a> from the original on September 4, 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">September 24,</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=National+Institutes+of+Health+%28NIH%29&amp;rft.atitle=NIH+launches+new+collaboration+to+develop+gene-based+cures+for+sickle+cell+disease+and+HIV+on+global+scale&amp;rft.date=2019-10-23&amp;rft_id=https%3A%2F%2Fwww.nih.gov%2Fnews-events%2Fnews-releases%2Fnih-launches-new-collaboration-develop-gene-based-cures-sickle-cell-disease-hiv-global-scale&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-M121-29"><span class="mw-cite-backlink">^ <a href="#cite_ref-M121_29-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-M121_29-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-M121_29-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-M121_29-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-M121_29-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-M121_29-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text">Mandell, Bennett, and Dolan (2010). Chapter 121.</span> </li> <li id="cite_note-WHOCase2007-30"><span class="mw-cite-backlink">^ <a href="#cite_ref-WHOCase2007_30-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-WHOCase2007_30-15"><sup><i><b>p</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://www.who.int/hiv/pub/guidelines/HIVstaging150307.pdf"><i>WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children</i></a> <span class="cs1-format">(PDF)</span>. Geneva: World Health Organization. 2007. pp.&#160;6–16. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-92-4-159562-9" title="Special:BookSources/978-92-4-159562-9"><bdi>978-92-4-159562-9</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20131031044253/http://www.who.int/hiv/pub/guidelines/HIVstaging150307.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on October 31, 2013.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=WHO+case+definitions+of+HIV+for+surveillance+and+revised+clinical+staging+and+immunological+classification+of+HIV-related+disease+in+adults+and+children&amp;rft.place=Geneva&amp;rft.pages=6-16&amp;rft.pub=World+Health+Organization&amp;rft.date=2007&amp;rft.isbn=978-92-4-159562-9&amp;rft_id=https%3A%2F%2Fwww.who.int%2Fhiv%2Fpub%2Fguidelines%2FHIVstaging150307.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-31"><span class="mw-cite-backlink"><b><a href="#cite_ref-31">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://books.google.com/books?id=-HRJOElZch8C&amp;pg=PA25"><i>Diseases and disorders</i></a>. Tarrytown, NY: Marshall Cavendish. 2008. p.&#160;25. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-7614-7771-6" title="Special:BookSources/978-0-7614-7771-6"><bdi>978-0-7614-7771-6</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150919012701/https://books.google.com/books?id=-HRJOElZch8C&amp;pg=PA25">Archived</a> from the original on September 19, 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">June 27,</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Diseases+and+disorders&amp;rft.place=Tarrytown%2C+NY&amp;rft.pages=25&amp;rft.pub=Marshall+Cavendish&amp;rft.date=2008&amp;rft.isbn=978-0-7614-7771-6&amp;rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3D-HRJOElZch8C%26pg%3DPA25&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-M118-32"><span class="mw-cite-backlink">^ <a href="#cite_ref-M118_32-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-M118_32-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-M118_32-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-M118_32-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-M118_32-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-M118_32-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-M118_32-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-M118_32-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-M118_32-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-M118_32-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-M118_32-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-M118_32-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-M118_32-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-M118_32-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-M118_32-14"><sup><i><b>o</b></i></sup></a></span> <span class="reference-text">Mandell, Bennett, and Dolan (2010). Chapter 118.</span> </li> <li id="cite_note-Deut2010-33"><span class="mw-cite-backlink">^ <a href="#cite_ref-Deut2010_33-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Deut2010_33-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Deut2010_33-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Deut2010_33-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Deut2010_33-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Deut2010_33-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Deut2010_33-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Deut2010_33-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Deut2010_33-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-Deut2010_33-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-Deut2010_33-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-Deut2010_33-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-Deut2010_33-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-Deut2010_33-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-Deut2010_33-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-Deut2010_33-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-Deut2010_33-16"><sup><i><b>q</b></i></sup></a> <a href="#cite_ref-Deut2010_33-17"><sup><i><b>r</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVogelSchwarze-ZanderWasmuthSpengler2010" class="citation journal cs1">Vogel M, Schwarze-Zander C, Wasmuth JC, Spengler U, Sauerbruch T, Rockstroh JK (July 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915483">"The treatment of patients with HIV"</a>. <i>Deutsches Ärzteblatt International</i>. <b>107</b> (28–29): 507–15, quiz 516. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3238%2Farztebl.2010.0507">10.3238/arztebl.2010.0507</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915483">2915483</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20703338">20703338</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Deutsches+%C3%84rzteblatt+International&amp;rft.atitle=The+treatment+of+patients+with+HIV&amp;rft.volume=107&amp;rft.issue=28%E2%80%9329&amp;rft.pages=507-15%2C+quiz+516&amp;rft.date=2010-07&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2915483%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F20703338&amp;rft_id=info%3Adoi%2F10.3238%2Farztebl.2010.0507&amp;rft.aulast=Vogel&amp;rft.aufirst=M&amp;rft.au=Schwarze-Zander%2C+C&amp;rft.au=Wasmuth%2C+JC&amp;rft.au=Spengler%2C+U&amp;rft.au=Sauerbruch%2C+T&amp;rft.au=Rockstroh%2C+JK&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2915483&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-34"><span class="mw-cite-backlink"><b><a href="#cite_ref-34">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEvian2006" class="citation book cs1">Evian C (2006). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=WauaC7M0yGcC&amp;pg=PA29"><i>Primary HIV/AIDS care: a practical guide for primary health care personnel in a clinical and supportive setting</i></a> (Updated 4th&#160;ed.). Houghton [South Africa]: Jacana. p.&#160;29. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-1-77009-198-6" title="Special:BookSources/978-1-77009-198-6"><bdi>978-1-77009-198-6</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150911043536/https://books.google.com/books?id=WauaC7M0yGcC&amp;pg=PA29">Archived</a> from the original on September 11, 2015<span class="reference-accessdate">. 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Reeders JW, Goodman PC (eds.). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=xmFBtyPGOQIC&amp;pg=PA19"><i>Radiology of AIDS</i></a>. Berlin [u.a.]: Springer. p.&#160;19. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-3-540-66510-6" title="Special:BookSources/978-3-540-66510-6"><bdi>978-3-540-66510-6</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160509101646/https://books.google.com/books?id=xmFBtyPGOQIC&amp;pg=PA19">Archived</a> from the original on May 9, 2016<span class="reference-accessdate">. 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Retrieved <span class="nowrap">July 24,</span> 2012</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Independent&amp;rft.atitle=Tributes+to+Arthur+Ashe&amp;rft.date=1993-02-08&amp;rft_id=https%3A%2F%2Fwww.independent.co.uk%2Fnews%2Ftributes-to-arthur-ashe-1471622.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-296"><span class="mw-cite-backlink"><b><a href="#cite_ref-296">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCosgrove" class="citation web cs1">Cosgrove B. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20120814045129/http://life.time.com/history/behind-the-picture-the-photo-that-changed-the-face-of-aids/#1">"Behind the Picture: The Photo That Changed the Face of AIDS"</a>. <i>LIFE magazine</i>. 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Retrieved <span class="nowrap">April 9,</span> 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=National+Post&amp;rft.atitle=A+fraudster%2C+not+a+murderer&amp;rft.date=2010-03-30&amp;rft_id=https%3A%2F%2Fnationalpost.com%2Fopinion%2Fcolumnists%2Fstory.html%3Fid%3D2c6dca9a-cf31-45e0-8bab-510069a10a9d&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-302"><span class="mw-cite-backlink"><b><a href="#cite_ref-302">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation news cs1"><a rel="nofollow" class="external text" href="http://tribune.com.pk/story/513598/virgin-cure-three-women-killed-to-cure-aids/">"<span class="cs1-kern-left"></span>'Virgin cure': Three women killed to 'cure' Aids"</a>. <i><a href="/wiki/International_Herald_Tribune" title="International Herald Tribune">International Herald Tribune</a></i>. 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Retrieved <span class="nowrap">September 14,</span> 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=International+Herald+Tribune&amp;rft.atitle=%27Virgin+cure%27%3A+Three+women+killed+to+%27cure%27+Aids&amp;rft.date=2013-02-28&amp;rft_id=http%3A%2F%2Ftribune.com.pk%2Fstory%2F513598%2Fvirgin-cure-three-women-killed-to-cure-aids%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-303"><span class="mw-cite-backlink"><b><a href="#cite_ref-303">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJenny2010" class="citation book cs1">Jenny C (2010). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=BKILM5KWFKwC&amp;pg=PA187"><i>Child Abuse and Neglect: Diagnosis, Treatment and Evidence – Expert Consult</i></a>. 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Retrieved <span class="nowrap">June 27,</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Child+Abuse+and+Neglect%3A+Diagnosis%2C+Treatment+and+Evidence+%E2%80%93+Expert+Consult&amp;rft.pages=187&amp;rft.pub=Elsevier+Health+Sciences&amp;rft.date=2010&amp;rft.isbn=978-1-4377-3621-2&amp;rft.aulast=Jenny&amp;rft.aufirst=Carole&amp;rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DBKILM5KWFKwC%26pg%3DPA187&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-304"><span class="mw-cite-backlink"><b><a href="#cite_ref-304">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKlot,_JenniferMonica_Kathina_Juma2011" class="citation book cs1">Klot, Jennifer, Monica Kathina Juma (2011). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=du0aR53YsYMC&amp;pg=PA47"><i>HIV/AIDS, Gender, Human Security and Violence in Southern Africa</i></a>. Pretoria: Africa Institute of South Africa. p.&#160;47. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-7983-0253-1" title="Special:BookSources/978-0-7983-0253-1"><bdi>978-0-7983-0253-1</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160426060547/https://books.google.com/books?id=du0aR53YsYMC&amp;pg=PA47">Archived</a> from the original on April 26, 2016<span class="reference-accessdate">. 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Oxford University Press. p.&#160;407. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0190239404" title="Special:BookSources/978-0190239404"><bdi>978-0190239404</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20231221043736/https://books.google.com/books?id=MNsmDAAAQBAJ&amp;pg=PA407#v=onepage&amp;q&amp;f=false">Archived</a> from the original on December 21, 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">December 10,</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Women%27s+Issues+for+a+New+Generation%3A+A+Social+Work+Perspective&amp;rft.pages=407&amp;rft.pub=Oxford+University+Press&amp;rft.date=2016&amp;rft.isbn=978-0190239404&amp;rft.aulast=Ukockis&amp;rft.aufirst=Gail&amp;rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DMNsmDAAAQBAJ%26pg%3DPA407&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-RASEFSS-306"><span class="mw-cite-backlink"><b><a href="#cite_ref-RASEFSS_306-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGlazzardStones2020" class="citation book cs1">Glazzard J, Stones S (2020). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=8ZnpDwAAQBAJ&amp;pg=PA87"><i>Relationships and Sex Education for Secondary Schools (2020): A Practical Toolkit for Teachers</i></a>. Critical Publishing. p.&#160;87. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-1913063689" title="Special:BookSources/978-1913063689"><bdi>978-1913063689</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20231221043746/https://books.google.com/books?id=8ZnpDwAAQBAJ&amp;pg=PA87#v=onepage&amp;q&amp;f=false">Archived</a> from the original on December 21, 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">December 10,</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Relationships+and+Sex+Education+for+Secondary+Schools+%282020%29%3A+A+Practical+Toolkit+for+Teachers&amp;rft.pages=87&amp;rft.pub=Critical+Publishing&amp;rft.date=2020&amp;rft.isbn=978-1913063689&amp;rft.aulast=Glazzard&amp;rft.aufirst=Jonathan&amp;rft.au=Stones%2C+Samuel&amp;rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3D8ZnpDwAAQBAJ%26pg%3DPA87&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-307"><span class="mw-cite-backlink"><b><a href="#cite_ref-307">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20150212142740/http://www.nat.org.uk/media/Files/PDF%20documents/Mori_2014_report_FINAL.pdf">"HIV Public Knowledge and Attitudes 2014"</a> <span class="cs1-format">(PDF)</span>. <i>National AIDS Trust</i>. November 2014. p.&#160;9. Archived from <a rel="nofollow" class="external text" href="http://www.nat.org.uk/media/Files/PDF%20documents/Mori_2014_report_FINAL.pdf">the original</a> <span class="cs1-format">(PDF)</span> on February 12, 2015<span class="reference-accessdate">. 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"HIV is not the cause of AIDS". <i>Science</i>. <b>241</b> (4865): 514, 517. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1988Sci...241..514D">1988Sci...241..514D</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.3399880">10.1126/science.3399880</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3399880">3399880</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Science&amp;rft.atitle=HIV+is+not+the+cause+of+AIDS&amp;rft.volume=241&amp;rft.issue=4865&amp;rft.pages=514%2C+517&amp;rft.date=1988-07&amp;rft_id=info%3Apmid%2F3399880&amp;rft_id=info%3Adoi%2F10.1126%2Fscience.3399880&amp;rft_id=info%3Abibcode%2F1988Sci...241..514D&amp;rft.aulast=Duesberg&amp;rft.aufirst=P&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCohen1994" class="citation journal cs1">Cohen J (December 1994). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20070101111630/http://www.sciencemag.org/feature/data/cohen/266-5191-1642a.pdf">"The Duesberg phenomenon"</a> <span class="cs1-format">(PDF)</span>. <i>Science</i>. <b>266</b> (5191): 1642–44. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1994Sci...266.1642C">1994Sci...266.1642C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.7992043">10.1126/science.7992043</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7992043">7992043</a>. Archived from <a rel="nofollow" class="external text" href="http://www.sciencemag.org/feature/data/cohen/266-5191-1642a.pdf">the original</a> <span class="cs1-format">(PDF)</span> on January 1, 2007.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Science&amp;rft.atitle=The+Duesberg+phenomenon&amp;rft.volume=266&amp;rft.issue=5191&amp;rft.pages=1642-44&amp;rft.date=1994-12&amp;rft_id=info%3Apmid%2F7992043&amp;rft_id=info%3Adoi%2F10.1126%2Fscience.7992043&amp;rft_id=info%3Abibcode%2F1994Sci...266.1642C&amp;rft.aulast=Cohen&amp;rft.aufirst=J&amp;rft_id=http%3A%2F%2Fwww.sciencemag.org%2Ffeature%2Fdata%2Fcohen%2F266-5191-1642a.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-Kalichman-311"><span class="mw-cite-backlink"><b><a href="#cite_ref-Kalichman_311-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKalichman2009" class="citation book cs1"><a href="/wiki/Seth_Kalichman" title="Seth Kalichman">Kalichman S</a> (2009). <span class="id-lock-registration" title="Free registration required"><a rel="nofollow" class="external text" href="https://archive.org/details/denyingaidsconsp0000kali"><i>Denying AIDS: Conspiracy Theories, Pseudoscience, and Human Tragedy</i></a></span>. New York: Copernicus Books (<a href="/wiki/Springer_Science%2BBusiness_Media" title="Springer Science+Business Media">Springer Science+Business Media</a>). <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-387-79475-4" title="Special:BookSources/978-0-387-79475-4"><bdi>978-0-387-79475-4</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Denying+AIDS%3A+Conspiracy+Theories%2C+Pseudoscience%2C+and+Human+Tragedy&amp;rft.place=New+York&amp;rft.pub=Copernicus+Books+%28Springer+Science%2BBusiness+Media%29&amp;rft.date=2009&amp;rft.isbn=978-0-387-79475-4&amp;rft.aulast=Kalichman&amp;rft.aufirst=Seth&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fdenyingaidsconsp0000kali&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-SmithNovella-312"><span class="mw-cite-backlink"><b><a href="#cite_ref-SmithNovella_312-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSmithNovella2007" class="citation journal cs1">Smith TC, Novella SP (August 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949841">"HIV denial in the Internet era"</a>. <i>PLOS Medicine</i>. <b>4</b> (8): e256. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pmed.0040256">10.1371/journal.pmed.0040256</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a>&#160;<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949841">1949841</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17713982">17713982</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=PLOS+Medicine&amp;rft.atitle=HIV+denial+in+the+Internet+era&amp;rft.volume=4&amp;rft.issue=8&amp;rft.pages=e256&amp;rft.date=2007-08&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1949841%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F17713982&amp;rft_id=info%3Adoi%2F10.1371%2Fjournal.pmed.0040256&amp;rft.aulast=Smith&amp;rft.aufirst=TC&amp;rft.au=Novella%2C+SP&amp;rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1949841&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-consensus-313"><span class="mw-cite-backlink"><b><a href="#cite_ref-consensus_313-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVarious2010" class="citation web cs1">Various (January 14, 2010). <a rel="nofollow" class="external text" href="https://www.niaid.nih.gov/topics/HIVAIDS/Understanding/howHIVCausesAIDS/Pages/HIVcausesAIDS.aspx">"Resources and Links, HIV-AIDS Connection"</a>. <a href="/wiki/National_Institute_of_Allergy_and_Infectious_Diseases" title="National Institute of Allergy and Infectious Diseases">National Institute of Allergy and Infectious Diseases</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20100407225045/http://www.niaid.nih.gov/topics/HIVAIDS/Understanding/howHIVCausesAIDS/pages/hivcausesaids.aspx">Archived</a> from the original on April 7, 2010<span class="reference-accessdate">. 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Central Intelligence Agency. Archived from <a rel="nofollow" class="external text" href="https://www.cia.gov/library/center-for-the-study-of-intelligence/csi-publications/csi-studies/studies/vol53no4/soviet-bloc-intelligence-and-its-aids.html">the original</a> on May 14, 2011.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Operation+INFEKTION+Soviet+Bloc+Intelligence+and+Its+AIDS+Disinformation+Campaign&amp;rft.pub=Central+Intelligence+Agency&amp;rft.date=2009&amp;rft.aulast=Boghardt&amp;rft.aufirst=Thomas&amp;rft_id=https%3A%2F%2Fwww.cia.gov%2Flibrary%2Fcenter-for-the-study-of-intelligence%2Fcsi-publications%2Fcsi-studies%2Fstudies%2Fvol53no4%2Fsoviet-bloc-intelligence-and-its-aids.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-318"><span class="mw-cite-backlink"><b><a href="#cite_ref-318">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.cdc.gov/eval/indicators/index.htm">"Indicators – Program Evaluation – CDC"</a>. <i>U.S. <a href="/wiki/Centers_for_Disease_Control_and_Prevention" title="Centers for Disease Control and Prevention">Centers for Disease Control and Prevention</a> (CDC)</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180823210732/https://www.cdc.gov/eval/indicators/index.htm">Archived</a> from the original on August 23, 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">August 24,</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=U.S.+Centers+for+Disease+Control+and+Prevention+%28CDC%29&amp;rft.atitle=Indicators+%E2%80%93+Program+Evaluation+%E2%80%93+CDC&amp;rft_id=https%3A%2F%2Fwww.cdc.gov%2Feval%2Findicators%2Findex.htm&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-319"><span class="mw-cite-backlink"><b><a href="#cite_ref-319">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.measureevaluation.org/community-based-indicators">"Community-Based Indicators for HIV Programs – MEASURE Evaluation"</a>. <i>measureevaluation.org</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180825002500/https://www.measureevaluation.org/community-based-indicators">Archived</a> from the original on August 25, 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">August 24,</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=measureevaluation.org&amp;rft.atitle=Community-Based+Indicators+for+HIV+Programs+%E2%80%93+MEASURE+Evaluation&amp;rft_id=https%3A%2F%2Fwww.measureevaluation.org%2Fcommunity-based-indicators&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> <li id="cite_note-320"><span class="mw-cite-backlink"><b><a href="#cite_ref-320">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.who.int/hiv/data/en/">"Data and statistics"</a>. <i>World Health Organization</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180902021227/http://www.who.int/hiv/data/en/">Archived</a> from the original on September 2, 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">August 24,</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=World+Health+Organization&amp;rft.atitle=Data+and+statistics&amp;rft_id=https%3A%2F%2Fwww.who.int%2Fhiv%2Fdata%2Fen%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading3"><h3 id="Notes">Notes</h3></div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMandellBennettDolin2010" class="citation book cs1">Mandell GL, Bennett JE, Dolin R, eds. (2010). <a rel="nofollow" class="external text" href="https://scholar.archive.org/work/z77imzos6bhytbprezvca7hazm/access/wayback/https://watermark.silverchair.com/41-2-277a.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAZswggGXBgkqhkiG9w0BBwagggGIMIIBhAIBADCCAX0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMAuaomuvi_NJumlw3AgEQgIIBThDTgJTUHxl_S5bfxbWGGvQbB_DGg6AJIYlDrM4BLmasQkp6-pvVLXhOk14_62G__HhvAFduajMAsQTd5izB5pcwwrqpdfwBuH2Vxf1K83RmRNz2cJxhSQuwALrOcRmxdgbLkEo0E1IghVRtVnpOKxNzQxbu6FoI7x8WGQlnk61Y_jEFVtZLRD4CZrCrneZ0UimR8XeTzqc9Lj-iqFM6_0Zk3fD2e_KFFadbsY8kb9qVjN9tBxQrVsvKRYLpZx1sNpc4E8CbZ0HYAWs8N6VyAjdV5yF8L2x80mMQ_EIaeZghakmXfGTj0KbD0CSvjXHICLWsk_-i_UGF_vsC-0mIu4WOBfJxEtuAmHUgpZ4UwOOfKyuZYmCU4n0ADmPeniOozSuZstMHnsukaGthW5wGEfIMYkbzr7Q_aO2H6PrGa5uDwiBJHMoZOQ04S92I_3E"><i>Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases</i></a> <span class="cs1-format">(PDF)</span> (7th&#160;ed.). Philadelphia, PA: Churchill Livingstone/Elsevier. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a>&#160;<a href="/wiki/Special:BookSources/978-0-443-06839-3" title="Special:BookSources/978-0-443-06839-3"><bdi>978-0-443-06839-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Mandell%2C+Douglas%2C+and+Bennett%27s+Principles+and+Practice+of+Infectious+Diseases&amp;rft.place=Philadelphia%2C+PA&amp;rft.edition=7th&amp;rft.pub=Churchill+Livingstone%2FElsevier&amp;rft.date=2010&amp;rft.isbn=978-0-443-06839-3&amp;rft_id=https%3A%2F%2Fscholar.archive.org%2Fwork%2Fz77imzos6bhytbprezvca7hazm%2Faccess%2Fwayback%2Fhttps%3A%2F%2Fwatermark.silverchair.com%2F41-2-277a.pdf%3Ftoken%3DAQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAZswggGXBgkqhkiG9w0BBwagggGIMIIBhAIBADCCAX0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMAuaomuvi_NJumlw3AgEQgIIBThDTgJTUHxl_S5bfxbWGGvQbB_DGg6AJIYlDrM4BLmasQkp6-pvVLXhOk14_62G&#95;_HhvAFduajMAsQTd5izB5pcwwrqpdfwBuH2Vxf1K83RmRNz2cJxhSQuwALrOcRmxdgbLkEo0E1IghVRtVnpOKxNzQxbu6FoI7x8WGQlnk61Y_jEFVtZLRD4CZrCrneZ0UimR8XeTzqc9Lj-iqFM6_0Zk3fD2e_KFFadbsY8kb9qVjN9tBxQrVsvKRYLpZx1sNpc4E8CbZ0HYAWs8N6VyAjdV5yF8L2x80mMQ_EIaeZghakmXfGTj0KbD0CSvjXHICLWsk_-i_UGF_vsC-0mIu4WOBfJxEtuAmHUgpZ4UwOOfKyuZYmCU4n0ADmPeniOozSuZstMHnsukaGthW5wGEfIMYkbzr7Q_aO2H6PrGa5uDwiBJHMoZOQ04S92I_3E&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJoint_United_Nations_Programme_on_HIV/AIDS_(UNAIDS)2011" class="citation book cs1"><a href="/wiki/Joint_United_Nations_Programme_on_HIV/AIDS" title="Joint United Nations Programme on HIV/AIDS">Joint United Nations Programme on HIV/AIDS (UNAIDS)</a> (2011). <a rel="nofollow" class="external text" href="http://www.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/2011/20111130_UA_Report_en.pdf"><i>Global HIV/AIDS Response, Epidemic update and health sector progress towards universal access</i></a> <span class="cs1-format">(PDF)</span>. Joint United Nations Programme on HIV/AIDS.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=book&amp;rft.btitle=Global+HIV%2FAIDS+Response%2C+Epidemic+update+and+health+sector+progress+towards+universal+access&amp;rft.pub=Joint+United+Nations+Programme+on+HIV%2FAIDS&amp;rft.date=2011&amp;rft.au=Joint+United+Nations+Programme+on+HIV%2FAIDS+%28UNAIDS%29&amp;rft_id=http%3A%2F%2Fwww.unaids.org%2Fen%2Fmedia%2Funaids%2Fcontentassets%2Fdocuments%2Funaidspublication%2F2011%2F20111130_UA_Report_en.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AHIV%2FAIDS" class="Z3988"></span></li></ul> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div> <div class="toccolours" style="float: right; margin: 0 0 0.8em 0.8em; width: 18.55em; border-collapse: collapse; font-size: 87%; clear: right; line-height:1.3em; background:#f9f9f9;border:1px solid #aaa;float:right;"><div style="float:left;"><span typeof="mw:File"><a href="https://meta.wikimedia.org/wiki/Wiki_Project_Med/App" title="meta:Wiki Project Med/App"><img alt="The offline app allows you to download all of Wikipedia&#39;s medical articles in an app to access them when you have no Internet." src="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Tango_Phone_medapp.svg/42px-Tango_Phone_medapp.svg.png" decoding="async" width="42" height="47" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Tango_Phone_medapp.svg/63px-Tango_Phone_medapp.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/82/Tango_Phone_medapp.svg/84px-Tango_Phone_medapp.svg.png 2x" data-file-width="42" data-file-height="47" /></a></span></div><div style="float:left;width:6px;padding:1px;height:47px;"></div>Wikipedia's health care articles can be viewed offline with the <b><a href="https://meta.wikimedia.org/wiki/Wiki_Project_Med/App" class="extiw" title="meta:Wiki Project Med/App">Medical Wikipedia app</a></b>.</div> <ul><li><a rel="nofollow" class="external text" href="https://www.unaids.org/en/">UNAIDS</a> – Joint United Nations Program on HIV/AIDS</li> <li><a rel="nofollow" class="external text" href="https://hivinfo.nih.gov/home-page">HIVinfo</a> – Information on HIV/AIDS treatment, prevention, and research, U.S. Department of Health and Human Services</li> <li><a rel="nofollow" class="external text" href="https://jamanetwork.com/journals/jama/article-abstract/2688574">2018 Recommendations of the International Antiviral Society</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output 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li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-label="Navbox" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q12199" class="extiw" title="d:Q12199">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-11" title="ICD-11">11</a></b>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse/latest-release/mms/en#236924369">1C60</a>, <a rel="nofollow" class="external text" href="https://icd.who.int/browse/latest-release/mms/en#771273482">1C61</a>, <a rel="nofollow" class="external text" href="https://icd.who.int/browse/latest-release/mms/en#1508081745">1C62</a></li><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10" title="ICD-10">10</a></b>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/B20">B20 </a> – <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/B24">B24 </a></li><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/List_of_ICD-9_codes" title="List of ICD-9 codes">9-CM</a></b>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=042">042</a>–<a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=044">044</a></li><li><b><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></b>: <a rel="nofollow" class="external text" href="https://omim.org/entry/609423">609423</a></li><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D000163">D000163</a></li><li><b><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a></b>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb5938.htm">5938</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">External resources</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></b>: <a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/medlineplus/ency/article/000594.htm">000594</a></li><li><b><a href="/wiki/EMedicine" title="EMedicine">eMedicine</a></b>: <a rel="nofollow" class="external text" href="https://emedicine.medscape.com/emerg/253-overview">emerg/253</a></li><li><b><a href="/wiki/Patient_UK" title="Patient UK">Patient UK</a></b>: <a rel="nofollow" class="external text" href="https://patient.info/doctor/acquired-immune-deficiency-syndrome-aids">HIV/AIDS</a></li></ul></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="HIV/AIDS_topics" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:HIV_and_AIDS" title="Template:HIV and AIDS"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:HIV_and_AIDS" title="Template talk:HIV and AIDS"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:HIV_and_AIDS" title="Special:EditPage/Template:HIV and AIDS"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="HIV/AIDS_topics" style="font-size:114%;margin:0 4em"><a href="/wiki/HIV" title="HIV">HIV</a>/<a class="mw-selflink selflink">AIDS</a> topics</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">HIV</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV" title="HIV">HIV</a> <ul><li><a href="/wiki/Lentivirus" title="Lentivirus">Lentivirus</a></li> <li><a href="/wiki/Structure_and_genome_of_HIV" title="Structure and genome of HIV">structure and genome</a></li> <li><a href="/wiki/Subtypes_of_HIV" title="Subtypes of HIV">subtypes</a></li> <li><a href="/wiki/CDC_classification_system_for_HIV_infection" title="CDC classification system for HIV infection">CDC classification</a></li> <li><a href="/wiki/HIV_disease_progression_rates" title="HIV disease progression rates">disease progression rates</a></li> <li><a href="/wiki/National_Addiction_and_HIV_Data_Archive_Program" title="National Addiction and HIV Data Archive Program">National Addiction and HIV Data Archive Program</a></li></ul></li> <li><a class="mw-selflink selflink">HIV/AIDS</a> <ul><li><a href="/wiki/Diagnosis_of_HIV/AIDS" title="Diagnosis of HIV/AIDS">diagnosis</a></li> <li><a href="/wiki/Management_of_HIV/AIDS" title="Management of HIV/AIDS">management</a></li> <li><a href="/wiki/Pathophysiology_of_HIV/AIDS" title="Pathophysiology of HIV/AIDS">pathophysiology</a></li> <li><a href="/wiki/Prevention_of_HIV/AIDS" title="Prevention of HIV/AIDS">prevention</a></li> <li><a href="/wiki/HIV/AIDS_research" title="HIV/AIDS research">research</a></li> <li><a href="/wiki/HIV_vaccine" class="mw-redirect" title="HIV vaccine">vaccination</a></li> <li><a href="/wiki/Pre-exposure_prophylaxis_for_HIV_prevention" title="Pre-exposure prophylaxis for HIV prevention">PrEP</a></li></ul></li> <li><a href="/wiki/WHO_disease_staging_system_for_HIV_infection_and_disease" title="WHO disease staging system for HIV infection and disease">WHO disease staging system for HIV infection and disease</a> <ul><li><a href="/wiki/WHO_Disease_Staging_System_for_HIV_Infection_and_Disease_in_Children" title="WHO Disease Staging System for HIV Infection and Disease in Children">Children</a></li> <li><a href="/wiki/WHO_Disease_Staging_System_for_HIV_Infection_and_Disease_in_Adults_and_Adolescents" title="WHO Disease Staging System for HIV Infection and Disease in Adults and Adolescents">Teens / Adults</a></li></ul></li> <li><a href="/wiki/List_of_countries_by_HIV/AIDS_adult_prevalence_rate" class="mw-redirect" title="List of countries by HIV/AIDS adult prevalence rate">Countries by AIDS prevalence rate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Conditions</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Signs_and_symptoms_of_HIV/AIDS" title="Signs and symptoms of HIV/AIDS">Signs and symptoms</a></li> <li><a href="/wiki/AIDS-defining_clinical_condition" title="AIDS-defining clinical condition">AIDS-defining clinical condition</a></li> <li><a href="/wiki/Diffuse_infiltrative_lymphocytosis_syndrome" title="Diffuse infiltrative lymphocytosis syndrome">Diffuse infiltrative lymphocytosis syndrome</a></li> <li><a href="/wiki/HIV-associated_lipodystrophy" title="HIV-associated lipodystrophy">Lipodystrophy</a></li> <li><a href="/wiki/HIV-associated_nephropathy" title="HIV-associated nephropathy">Nephropathy</a></li> <li><a href="/wiki/HIV-associated_cardiomyopathy" title="HIV-associated cardiomyopathy">Cardiomyopathy</a></li> <li><a href="/wiki/HIV-associated_neurocognitive_disorder" title="HIV-associated neurocognitive disorder">Neurocognitive disorders</a></li> <li><a href="/wiki/HIV-associated_pruritus" title="HIV-associated pruritus">Pruritus</a></li> <li><a href="/wiki/Opportunistic_infection" title="Opportunistic infection">Opportunistic infection</a></li> <li><a href="/wiki/HIV_superinfection" title="HIV superinfection">Superinfection</a></li> <li><a href="/wiki/Tuberculosis" title="Tuberculosis">Tuberculosis co-infection</a></li> <li><a href="/wiki/HIV_Drug_Resistance_Database" title="HIV Drug Resistance Database">HIV Drug Resistance Database</a></li> <li><a href="/wiki/Innate_resistance_to_HIV" title="Innate resistance to HIV">Innate resistance to HIV</a></li> <li><a href="/wiki/Serostatus" title="Serostatus">Serostatus</a></li> <li><a href="/wiki/HIV-positive_people" title="HIV-positive people">HIV-positive people</a></li> <li><a href="/wiki/Nutritional_challenges_of_HIV/AIDS" title="Nutritional challenges of HIV/AIDS">Nutrition</a></li> <li><a href="/wiki/HIV_and_pregnancy" title="HIV and pregnancy">Pregnancy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">History</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/History_of_HIV/AIDS" title="History of HIV/AIDS">History</a></li> <li><a href="/wiki/Epidemiology_of_HIV/AIDS" title="Epidemiology of HIV/AIDS">Epidemiology</a> <ul><li><a href="/wiki/Multiple_sex_partners" title="Multiple sex partners">Multiple sex partners</a></li></ul></li> <li><a href="/wiki/Timeline_of_HIV/AIDS" title="Timeline of HIV/AIDS">Timeline</a></li> <li><a href="/wiki/World_AIDS_Museum_and_Educational_Center" title="World AIDS Museum and Educational Center">World AIDS Museum</a></li> <li><a href="/wiki/Timothy_Ray_Brown" title="Timothy Ray Brown">Timothy Ray Brown</a></li> <li><a href="/wiki/Berlin_Patient" title="Berlin Patient">Berlin Patient</a></li> <li><a href="/wiki/Adam_Castillejo" title="Adam Castillejo">The London Patient</a></li> <li><a href="/wiki/Paul_Edmonds_(patient)" title="Paul Edmonds (patient)">City of Hope Patient</a></li> <li><a href="/wiki/Women_and_HIV/AIDS" title="Women and HIV/AIDS">Women and HIV/AIDS</a></li> <li><a href="/wiki/HIV_and_men_who_have_sex_with_men" title="HIV and men who have sex with men">HIV and homosexual men</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Social</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AIDS_orphan" title="AIDS orphan">AIDS orphan</a></li> <li><a href="/wiki/Religion_and_HIV/AIDS" title="Religion and HIV/AIDS">Religion</a> <ul><li><a href="/wiki/Catholic_Church_and_HIV/AIDS" title="Catholic Church and HIV/AIDS">Catholic Church and HIV/AIDS</a></li></ul></li> <li><a href="/wiki/Circumcision_and_HIV" title="Circumcision and HIV">Circumcision and HIV</a></li> <li><a href="/wiki/Criminal_transmission_of_HIV" title="Criminal transmission of HIV">Criminal transmission</a></li> <li><a href="/wiki/Discrimination_against_people_with_HIV/AIDS" title="Discrimination against people with HIV/AIDS">Discrimination against people</a></li> <li><a href="/wiki/Economic_impact_of_HIV/AIDS" title="Economic impact of HIV/AIDS">Economic impact</a> <ul><li><a href="/wiki/Cost_of_HIV_treatment" title="Cost of HIV treatment">Cost of treatment</a></li></ul></li> <li><a href="/wiki/HIV-affected_community" title="HIV-affected community">HIV-affected community</a></li> <li><a href="/wiki/HIV/AIDS_activism" title="HIV/AIDS activism">HIV/AIDS activism</a></li> <li><a href="/wiki/HIV/AIDS_denialism" title="HIV/AIDS denialism">HIV/AIDS denialism</a></li> <li><a href="/wiki/Red_ribbon" title="Red ribbon">Red ribbon</a></li> <li><a href="/wiki/Safe_sex" title="Safe sex">Safe sex</a></li> <li><a href="/wiki/Sex_education" title="Sex education">Sex education</a></li> <li><a href="/wiki/List_of_HIV-positive_people" title="List of HIV-positive people">List of HIV-positive people</a></li> <li><a href="/wiki/People_With_AIDS" title="People With AIDS">People With AIDS Self-Empowerment Movement</a></li> <li><a href="/wiki/Sexually_transmitted_infections_in_the_pornography_industry" title="Sexually transmitted infections in the pornography industry">HIV/AIDS in the porn industry</a></li> <li><a href="/wiki/HIV.gov" title="HIV.gov">HIV.gov</a></li> <li><a href="/wiki/NAMES_Project_AIDS_Memorial_Quilt" title="NAMES Project AIDS Memorial Quilt">AIDS Memorial Quilt</a></li> <li><a href="/wiki/Product_Red" title="Product Red">Product Red</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Culture</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Discredited_HIV/AIDS_origins_theories" title="Discredited HIV/AIDS origins theories">Discredited HIV/AIDS origins theories</a></li> <li><a href="/wiki/European_and_Developing_Countries_Clinical_Trials_Partnership" title="European and Developing Countries Clinical Trials Partnership">European and Developing Countries Clinical Trials Partnership</a></li> <li><a href="/wiki/Elton_John_AIDS_Foundation" title="Elton John AIDS Foundation">Elton John AIDS Foundation</a></li> <li><a href="/wiki/International_AIDS_Conference" class="mw-redirect" title="International AIDS Conference">International AIDS Conference</a></li> <li><a href="/wiki/International_AIDS_Society" title="International AIDS Society">International AIDS Society</a></li> <li><a href="/wiki/Joint_United_Nations_Programme_on_HIV/AIDS" title="Joint United Nations Programme on HIV/AIDS">Joint United Nations Programme on HIV/AIDS (UNAIDS)</a></li> <li><a href="/wiki/Media_portrayal_of_HIV/AIDS" title="Media portrayal of HIV/AIDS">Media portrayal of HIV/AIDS</a></li> <li><a href="/wiki/Misconceptions_about_HIV/AIDS" title="Misconceptions about HIV/AIDS">Misconceptions about HIV/AIDS</a></li> <li><a href="/wiki/President%27s_Emergency_Plan_for_AIDS_Relief" title="President&#39;s Emergency Plan for AIDS Relief">President's Emergency Plan for AIDS Relief (PEPFAR)</a></li> <li><a href="/wiki/Sing_campaign" title="Sing campaign">The SING Campaign</a></li> <li><a href="/wiki/Solidays" title="Solidays">Solidays</a></li> <li><a href="/wiki/Treatment_Action_Campaign" title="Treatment Action Campaign">Treatment Action Campaign</a></li> <li><a href="/wiki/The_Global_Fund_to_Fight_AIDS,_Tuberculosis_and_Malaria" title="The Global Fund to Fight AIDS, Tuberculosis and Malaria">The Global Fund</a></li> <li><a href="/wiki/World_AIDS_Day" title="World AIDS Day">World AIDS Day</a></li> <li><a href="/wiki/Youth_Against_AIDS" title="Youth Against AIDS">YAA/Youthforce</a></li> <li><a href="/wiki/Free_Me_(Sia_song)" title="Free Me (Sia song)">"Free Me"</a></li> <li><a href="/wiki/Larry_Kramer" title="Larry Kramer">Larry Kramer</a> <ul><li><a href="/wiki/GMHC" title="GMHC">Gay Men's Health Crisis</a></li> <li><a href="/wiki/ACT_UP" title="ACT UP">ACT UP</a></li> <li><i><a href="/wiki/Reports_from_the_Holocaust" title="Reports from the Holocaust">Reports from the Holocaust</a></i></li> <li><a href="/wiki/AIDS%E2%80%93Holocaust_metaphor" title="AIDS–Holocaust metaphor">AIDS–Holocaust metaphor</a></li></ul></li> <li><a href="/wiki/Silence%3DDeath_Project" title="Silence=Death Project">Silence=Death Project</a></li> <li><a href="/wiki/Day_Without_Art" title="Day Without Art">Day Without Art</a></li> <li><a href="/wiki/The_Freddie_Mercury_Tribute_Concert" title="The Freddie Mercury Tribute Concert">The Freddie Mercury Tribute Concert</a></li> <li><a href="/wiki/Ayds" title="Ayds">Ayds</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Epidemiology_of_HIV/AIDS" title="Epidemiology of HIV/AIDS">Locations</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/HIV/AIDS_in_Africa" title="HIV/AIDS in Africa">Africa</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS_in_Angola" title="HIV/AIDS in Angola">Angola</a></li> <li><a href="/wiki/HIV/AIDS_in_Benin" title="HIV/AIDS in Benin">Benin</a></li> <li><a href="/wiki/HIV/AIDS_in_Botswana" title="HIV/AIDS in Botswana">Botswana</a></li> <li><a href="/wiki/HIV/AIDS_in_the_Democratic_Republic_of_the_Congo" title="HIV/AIDS in the Democratic Republic of the Congo">Democratic Republic of the Congo</a></li> <li><a href="/wiki/HIV/AIDS_in_Egypt" title="HIV/AIDS in Egypt">Egypt</a></li> <li><a href="/wiki/HIV/AIDS_in_Eswatini" title="HIV/AIDS in Eswatini">Eswatini</a></li> <li><a href="/wiki/HIV/AIDS_in_Ethiopia" title="HIV/AIDS in Ethiopia">Ethiopia</a></li> <li><a href="/wiki/HIV/AIDS_in_Ghana" title="HIV/AIDS in Ghana">Ghana</a></li> <li><a href="/wiki/HIV/AIDS_in_Guinea" title="HIV/AIDS in Guinea">Guinea</a></li> <li><a href="/wiki/HIV/AIDS_in_Ivory_Coast" title="HIV/AIDS in Ivory Coast">Côte d'Ivoire (Ivory Coast)</a></li> <li><a href="/wiki/HIV/AIDS_in_Kenya" title="HIV/AIDS in Kenya">Kenya</a></li> <li><a href="/wiki/HIV/AIDS_in_Lesotho" title="HIV/AIDS in Lesotho">Lesotho</a></li> <li><a href="/wiki/HIV/AIDS_in_Madagascar" title="HIV/AIDS in Madagascar">Madagascar</a></li> <li><a href="/wiki/HIV/AIDS_in_Malawi" title="HIV/AIDS in Malawi">Malawi</a></li> <li><a href="/wiki/HIV/AIDS_in_Mali" title="HIV/AIDS in Mali">Mali</a></li> <li><a href="/wiki/HIV/AIDS_in_Mozambique" title="HIV/AIDS in Mozambique">Mozambique</a></li> <li><a href="/wiki/HIV/AIDS_in_Namibia" title="HIV/AIDS in Namibia">Namibia</a></li> <li><a href="/wiki/HIV/AIDS_in_Niger" title="HIV/AIDS in Niger">Niger</a></li> <li><a href="/wiki/HIV/AIDS_in_Nigeria" title="HIV/AIDS in Nigeria">Nigeria</a></li> <li><a href="/wiki/HIV/AIDS_in_Rwanda" title="HIV/AIDS in Rwanda">Rwanda</a></li> <li><a href="/wiki/HIV/AIDS_in_Senegal" title="HIV/AIDS in Senegal">Senegal</a></li> <li><a href="/wiki/HIV/AIDS_in_Tanzania" title="HIV/AIDS in Tanzania">Tanzania</a></li> <li><a href="/wiki/HIV/AIDS_in_South_Africa" title="HIV/AIDS in South Africa">South Africa</a></li> <li><a href="/wiki/HIV/AIDS_in_Uganda" title="HIV/AIDS in Uganda">Uganda</a></li> <li><a href="/wiki/HIV/AIDS_in_Zambia" title="HIV/AIDS in Zambia">Zambia</a></li> <li><a href="/wiki/HIV/AIDS_in_Zimbabwe" title="HIV/AIDS in Zimbabwe">Zimbabwe</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/HIV/AIDS_in_Asia" title="HIV/AIDS in Asia">Asia</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS_in_Afghanistan" class="mw-redirect" title="HIV/AIDS in Afghanistan">Afghanistan</a></li> <li><a href="/wiki/HIV/AIDS_in_Armenia" title="HIV/AIDS in Armenia">Armenia</a></li> <li><a href="/wiki/HIV/AIDS_in_Azerbaijan" class="mw-redirect" title="HIV/AIDS in Azerbaijan">Azerbaijan</a></li> <li><a href="/wiki/HIV/AIDS_in_Bahrain" class="mw-redirect" title="HIV/AIDS in Bahrain">Bahrain</a></li> <li><a href="/wiki/HIV/AIDS_in_Bangladesh" title="HIV/AIDS in Bangladesh">Bangladesh</a></li> <li><a href="/wiki/HIV/AIDS_in_Bhutan" title="HIV/AIDS in Bhutan">Bhutan</a></li> <li><a href="/wiki/HIV/AIDS_in_Cambodia" title="HIV/AIDS in Cambodia">Cambodia</a></li> <li><a href="/wiki/HIV/AIDS_in_China" title="HIV/AIDS in China">China (PRC)</a> <ul><li><a href="/wiki/HIV/AIDS_in_Yunnan" title="HIV/AIDS in Yunnan">Yunnan</a></li></ul></li> <li><a href="/wiki/HIV/AIDS_in_East_Timor" title="HIV/AIDS in East Timor">East Timor</a></li> <li><a href="/wiki/HIV/AIDS_in_India" title="HIV/AIDS in India">India</a></li> <li><a href="/wiki/HIV/AIDS_in_Indonesia" title="HIV/AIDS in Indonesia">Indonesia</a></li> <li><a href="/wiki/HIV/AIDS_in_Iran" class="mw-redirect" title="HIV/AIDS in Iran">Iran</a></li> <li><a href="/wiki/HIV/AIDS_in_Iraq" title="HIV/AIDS in Iraq">Iraq</a></li> <li><a href="/wiki/HIV/AIDS_in_Japan" title="HIV/AIDS in Japan">Japan</a></li> <li><a href="/wiki/HIV/AIDS_in_Jordan" title="HIV/AIDS in Jordan">Jordan</a></li> <li><a href="/wiki/HIV/AIDS_in_North_Korea" class="mw-redirect" title="HIV/AIDS in North Korea">North Korea</a></li> <li><a href="/wiki/HIV/AIDS_in_Laos" title="HIV/AIDS in Laos">Laos</a></li> <li><a href="/wiki/HIV/AIDS_in_Malaysia" title="HIV/AIDS in Malaysia">Malaysia</a></li> <li><a href="/wiki/HIV/AIDS_in_Myanmar" title="HIV/AIDS in Myanmar">Myanmar (Burma)</a></li> <li><a href="/wiki/HIV/AIDS_in_Nepal" title="HIV/AIDS in Nepal">Nepal</a></li> <li><a href="/wiki/HIV/AIDS_in_Pakistan" title="HIV/AIDS in Pakistan">Pakistan</a></li> <li><a href="/wiki/HIV/AIDS_in_the_Philippines" title="HIV/AIDS in the Philippines">Philippines</a></li> <li><a href="/wiki/HIV/AIDS_in_Saudi_Arabia" class="mw-redirect" title="HIV/AIDS in Saudi Arabia">Saudi Arabia</a></li> <li><a href="/wiki/HIV/AIDS_in_Sri_Lanka" class="mw-redirect" title="HIV/AIDS in Sri Lanka">Sri Lanka</a></li> <li><a href="/wiki/HIV/AIDS_in_Taiwan" title="HIV/AIDS in Taiwan">Taiwan (ROC)</a></li> <li><a href="/wiki/HIV/AIDS_in_Thailand" title="HIV/AIDS in Thailand">Thailand</a></li> <li><a href="/wiki/HIV/AIDS_in_the_United_Arab_Emirates" title="HIV/AIDS in the United Arab Emirates">United Arab Emirates</a></li> <li><a href="/wiki/HIV/AIDS_in_Turkey" class="mw-redirect" title="HIV/AIDS in Turkey">Turkey</a></li> <li><a href="/wiki/HIV/AIDS_in_Vietnam" title="HIV/AIDS in Vietnam">Vietnam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/HIV/AIDS_in_Europe" title="HIV/AIDS in Europe">Europe</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS_in_the_United_Kingdom" title="HIV/AIDS in the United Kingdom">United Kingdom</a></li> <li><a href="/wiki/HIV/AIDS_in_Russia" title="HIV/AIDS in Russia">Russia</a></li> <li><a href="/wiki/HIV/AIDS_in_Ukraine" title="HIV/AIDS in Ukraine">Ukraine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/HIV/AIDS_in_North_America" title="HIV/AIDS in North America">North America</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS_in_Canada" title="HIV/AIDS in Canada">Canada</a></li> <li><a href="/wiki/HIV/AIDS_in_Mexico" title="HIV/AIDS in Mexico">Mexico</a></li> <li><a href="/wiki/HIV/AIDS_in_El_Salvador" title="HIV/AIDS in El Salvador">El Salvador</a></li> <li><a href="/wiki/HIV/AIDS_in_Guatemala" title="HIV/AIDS in Guatemala">Guatemala</a></li> <li><a href="/wiki/HIV/AIDS_in_Honduras" title="HIV/AIDS in Honduras">Honduras</a></li> <li><a href="/wiki/HIV/AIDS_in_Nicaragua" title="HIV/AIDS in Nicaragua">Nicaragua</a></li> <li><a href="/wiki/HIV/AIDS_in_the_United_States" title="HIV/AIDS in the United States">United States</a> <ul><li><a href="/wiki/HIV/AIDS_in_New_York_City" title="HIV/AIDS in New York City">New York City</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/HIV/AIDS_in_the_Caribbean" title="HIV/AIDS in the Caribbean">Caribbean</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS_in_Haiti" title="HIV/AIDS in Haiti">Haiti</a></li> <li><a href="/wiki/HIV/AIDS_in_Jamaica" title="HIV/AIDS in Jamaica">Jamaica</a></li> <li><a href="/wiki/HIV/AIDS_in_the_Dominican_Republic" title="HIV/AIDS in the Dominican Republic">Dominican Republic</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/HIV/AIDS_in_South_America" title="HIV/AIDS in South America">South America</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS_in_Argentina" title="HIV/AIDS in Argentina">Argentina</a></li> <li><a href="/wiki/HIV/AIDS_in_Bolivia" title="HIV/AIDS in Bolivia">Bolivia</a></li> <li><a href="/wiki/HIV/AIDS_in_Brazil" title="HIV/AIDS in Brazil">Brazil</a></li> <li><a href="/wiki/HIV/AIDS_in_Colombia" title="HIV/AIDS in Colombia">Colombia</a></li> <li><a href="/wiki/HIV/AIDS_in_Guyana" title="HIV/AIDS in Guyana">Guyana</a></li> <li><a href="/wiki/HIV/AIDS_in_Peru" title="HIV/AIDS in Peru">Peru</a></li> <li><a href="/wiki/HIV/AIDS_in_Uruguay" title="HIV/AIDS in Uruguay">Uruguay</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Oceania</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIV/AIDS_in_Australia" title="HIV/AIDS in Australia">Australia</a></li> <li><a href="/wiki/HIV/AIDS_in_New_Zealand" title="HIV/AIDS in New Zealand">New Zealand</a></li> <li><a href="/wiki/HIV/AIDS_in_Papua_New_Guinea" title="HIV/AIDS in Papua New Guinea">Papua New Guinea</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><a href="/wiki/List_of_countries_by_HIV/AIDS_adult_prevalence_rate" class="mw-redirect" title="List of countries by HIV/AIDS adult prevalence rate">List of countries by HIV/AIDS adult prevalence rate</a></li> <li><a href="/wiki/List_of_HIV/AIDS_cases_and_deaths_registered_by_region" title="List of HIV/AIDS cases and deaths registered by region">List of HIV/AIDS cases and deaths registered by region</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"></div><div role="navigation" class="navbox" aria-labelledby="Sexually_transmitted_infections_(STI)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:STD_and_STI" title="Template:STD and STI"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:STD_and_STI" title="Template talk:STD and STI"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:STD_and_STI" title="Special:EditPage/Template:STD and STI"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Sexually_transmitted_infections_(STI)" style="font-size:114%;margin:0 4em"><a href="/wiki/Sexually_transmitted_infection" title="Sexually transmitted infection">Sexually transmitted infections</a> (STI)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bacteria" title="Bacteria">Bacterial</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chancroid" title="Chancroid">Chancroid</a> (<i><a href="/wiki/Haemophilus_ducreyi" title="Haemophilus ducreyi">Haemophilus ducreyi</a></i>)</li> <li><a href="/wiki/Chlamydia_infection" class="mw-redirect" title="Chlamydia infection">Chlamydia</a>, <a href="/wiki/Lymphogranuloma_venereum" title="Lymphogranuloma venereum">lymphogranuloma venereum</a> (<i><a href="/wiki/Chlamydia_trachomatis" title="Chlamydia trachomatis">Chlamydia trachomatis</a></i>)</li> <li><a href="/wiki/Granuloma_inguinale" title="Granuloma inguinale">Donovanosis</a> (<i><a href="/wiki/Klebsiella_granulomatis" title="Klebsiella granulomatis">Klebsiella granulomatis</a></i>)</li> <li><a href="/wiki/Gonorrhea" title="Gonorrhea">Gonorrhea</a> (<i><a href="/wiki/Neisseria_gonorrhoeae" title="Neisseria gonorrhoeae">Neisseria gonorrhoeae</a></i>)</li> <li><a href="/wiki/Mycoplasma_hominis_infection" title="Mycoplasma hominis infection">Mycoplasma hominis infection</a> (<i><a href="/wiki/Mycoplasma_hominis" title="Mycoplasma hominis">Mycoplasma hominis</a></i>)</li> <li><a href="/wiki/Syphilis" title="Syphilis">Syphilis</a> (<i><a href="/wiki/Treponema_pallidum" title="Treponema pallidum">Treponema pallidum</a></i>)</li> <li><a href="/wiki/Ureaplasma_infection" class="mw-redirect" title="Ureaplasma infection">Ureaplasma infection</a> (<i><a href="/wiki/Ureaplasma_urealyticum" title="Ureaplasma urealyticum">Ureaplasma urealyticum</a></i>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protozoa" title="Protozoa">Protozoal</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Trichomoniasis" title="Trichomoniasis">Trichomoniasis</a> (<i><a href="/wiki/Trichomonas_vaginalis" title="Trichomonas vaginalis">Trichomonas vaginalis</a></i>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Parasitism" title="Parasitism">Parasitic</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Crab_louse" title="Crab louse">Crab louse</a></li> <li><a href="/wiki/Scabies" title="Scabies">Scabies</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Virus" title="Virus">Viral</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">AIDS</a> (<i><a href="/wiki/HIV" title="HIV">HIV-1/HIV-2</a></i>)</li> <li>Cancer <ul><li><a href="/wiki/Cervical_cancer" title="Cervical cancer">cervical</a></li> <li><a href="/wiki/Vulvar_cancer" title="Vulvar cancer">vulvar</a></li> <li><a href="/wiki/Penile_cancer" title="Penile cancer">penile</a></li> <li><a href="/wiki/Anal_cancer" title="Anal cancer">anal</a></li></ul></li> <li><a href="/wiki/Human_papillomavirus" class="mw-redirect" title="Human papillomavirus"><i>Human papillomavirus</i> (HPV)</a></li> <li><a href="/wiki/Genital_wart" title="Genital wart">Genital warts (<i>condyloma</i>)</a></li> <li><a href="/wiki/Hepatitis_B" title="Hepatitis B">Hepatitis B</a> (<i><a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">Hepatitis B virus</a></i>)</li> <li><a href="/wiki/Herpes" title="Herpes">Herpes simplex</a> <ul><li><a href="/wiki/Herpes_simplex_virus" title="Herpes simplex virus">HSV-1 &amp; HSV-2</a></li></ul></li> <li><a href="/wiki/Molluscum_contagiosum" title="Molluscum contagiosum">Molluscum contagiosum</a> (<i><a href="/wiki/Molluscum_contagiosum_virus" title="Molluscum contagiosum virus">MCV</a></i>)</li> <li><a href="/wiki/Zika_fever" title="Zika fever">Zika fever</a> (<i><a href="/wiki/Zika_virus" title="Zika virus">Zika virus</a></i>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General<br /><a href="/wiki/Inflammation" title="Inflammation">inflammation</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><span class="nobold"><i>female</i></span></dt> <dd><a href="/wiki/Cervicitis" title="Cervicitis">Cervicitis</a></dd> <dd><a href="/wiki/Pelvic_inflammatory_disease" title="Pelvic inflammatory disease">Pelvic inflammatory disease (PID)</a></dd></dl> <dl><dt><span class="nobold"><i>male</i></span></dt> <dd><a href="/wiki/Epididymitis" title="Epididymitis">Epididymitis</a></dd> <dd><a href="/wiki/Prostatitis" title="Prostatitis">Prostatitis</a></dd></dl> <dl><dt><span class="nobold"><i>either</i></span></dt> <dd><a href="/wiki/Proctitis" title="Proctitis">Proctitis</a></dd> <dd><a href="/wiki/Urethritis" title="Urethritis">Urethritis</a>/<a href="/wiki/Non-gonococcal_urethritis" title="Non-gonococcal urethritis">Non-gonococcal urethritis (NGU)</a></dd></dl> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Diseases_of_poverty" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Diseases_of_poverty" title="Template:Diseases of poverty"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Diseases_of_poverty" title="Template talk:Diseases of poverty"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Diseases_of_poverty" title="Special:EditPage/Template:Diseases of poverty"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Diseases_of_poverty" style="font-size:114%;margin:0 4em"><a href="/wiki/Diseases_of_poverty" title="Diseases of poverty">Diseases of poverty</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Diseases_of_poverty" title="Diseases of poverty">Diseases of poverty</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">AIDS</a></li> <li><a href="/wiki/Malaria" title="Malaria">Malaria</a></li> <li><a href="/wiki/Tuberculosis" title="Tuberculosis">Tuberculosis</a></li> <li><a href="/wiki/Measles" title="Measles">Measles</a></li> <li><a href="/wiki/Pneumonia" title="Pneumonia">Pneumonia</a></li> <li><a href="/wiki/Diarrhea" title="Diarrhea">Diarrheal diseases</a></li> <li><a href="/wiki/Plague_(disease)" title="Plague (disease)">Plague</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Neglected_tropical_diseases" title="Neglected tropical diseases">Neglected diseases</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholera" title="Cholera">Cholera</a></li> <li><a href="/wiki/Chagas_disease" title="Chagas disease">Chagas disease</a></li> <li><a href="/wiki/African_trypanosomiasis" title="African trypanosomiasis">African sleeping sickness</a></li> <li><a href="/wiki/Schistosomiasis" title="Schistosomiasis">Schistosomiasis</a></li> <li><a href="/wiki/Dracunculiasis" title="Dracunculiasis">Dracunculiasis</a></li> <li><a href="/wiki/Onchocerciasis" title="Onchocerciasis">River blindness</a></li> <li><a href="/wiki/Visceral_leishmaniasis" title="Visceral leishmaniasis">Leishmaniasis</a></li> <li><a href="/wiki/Trachoma" title="Trachoma">Trachoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Malnutrition" title="Malnutrition">Malnutrition</a></li> <li><a href="/wiki/Priority_review" title="Priority review">Priority review voucher</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Infectious_diseases_–_viral_systemic_diseases" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Viral_systemic_diseases" title="Template:Viral systemic diseases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Viral_systemic_diseases" title="Template talk:Viral systemic diseases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Viral_systemic_diseases" title="Special:EditPage/Template:Viral systemic diseases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Infectious_diseases_–_viral_systemic_diseases" style="font-size:114%;margin:0 4em"><a href="/wiki/Infection" title="Infection">Infectious diseases</a> – <a href="/wiki/Viral_disease" title="Viral disease">viral systemic diseases</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Oncovirus" title="Oncovirus">Oncovirus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></dt> <dd><i><a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">HBV</a></i> <dl><dd><a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">Hepatocellular carcinoma</a></dd></dl></dd> <dd><i><a href="/wiki/Papillomaviridae" title="Papillomaviridae">HPV</a></i> <dl><dd><a href="/wiki/Cervical_cancer" title="Cervical cancer">Cervical cancer</a></dd> <dd><a href="/wiki/Anal_cancer" title="Anal cancer">Anal cancer</a></dd> <dd><a href="/wiki/Penile_cancer" title="Penile cancer">Penile cancer</a></dd> <dd><a href="/wiki/Vulvar_cancer" title="Vulvar cancer">Vulvar cancer</a></dd> <dd><a href="/wiki/Vaginal_cancer" title="Vaginal cancer">Vaginal cancer</a></dd> <dd><a href="/wiki/HPV-positive_oropharyngeal_cancer" title="HPV-positive oropharyngeal cancer">Oropharyngeal cancer</a></dd></dl></dd> <dd><i><a href="/wiki/Kaposi%27s_sarcoma-associated_herpesvirus" title="Kaposi&#39;s sarcoma-associated herpesvirus">KSHV</a></i> <dl><dd><a href="/wiki/Kaposi%27s_sarcoma" title="Kaposi&#39;s sarcoma">Kaposi's sarcoma</a></dd></dl></dd> <dd><i><a href="/wiki/Epstein%E2%80%93Barr_virus" title="Epstein–Barr virus">EBV</a></i> <dl><dd><a href="/wiki/Nasopharyngeal_carcinoma" title="Nasopharyngeal carcinoma">Nasopharyngeal carcinoma</a></dd> <dd><a href="/wiki/Burkitt%27s_lymphoma" class="mw-redirect" title="Burkitt&#39;s lymphoma">Burkitt's lymphoma</a></dd> <dd><a href="/wiki/Hodgkin_lymphoma" title="Hodgkin lymphoma">Hodgkin lymphoma</a></dd> <dd><a href="/wiki/Follicular_dendritic_cell_sarcoma" title="Follicular dendritic cell sarcoma">Follicular dendritic cell sarcoma</a></dd> <dd><a href="/wiki/Extranodal_NK/T-cell_lymphoma,_nasal_type" title="Extranodal NK/T-cell lymphoma, nasal type">Extranodal NK/T-cell lymphoma, nasal type</a></dd></dl></dd> <dd><i><a href="/wiki/Merkel_cell_polyomavirus" title="Merkel cell polyomavirus">MCPyV</a></i> <dl><dd><a href="/wiki/Merkel-cell_carcinoma" title="Merkel-cell carcinoma">Merkel-cell carcinoma</a></dd></dl></dd></dl> <dl><dt><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></dt> <dd><i><a href="/wiki/Hepatitis_C_virus" title="Hepatitis C virus">HCV</a></i> <dl><dd><a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">Hepatocellular carcinoma</a></dd> <dd><a href="/wiki/Splenic_marginal_zone_lymphoma" title="Splenic marginal zone lymphoma">Splenic marginal zone lymphoma</a></dd></dl></dd> <dd><i><a href="/wiki/Human_T-lymphotropic_virus_1" title="Human T-lymphotropic virus 1">HTLV-I</a></i> <dl><dd><a href="/wiki/Adult_T-cell_leukemia/lymphoma" title="Adult T-cell leukemia/lymphoma">Adult T-cell leukemia/lymphoma</a></dd></dl></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immune_disorder" title="Immune disorder">Immune disorders</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/HIV" title="HIV">HIV</a></i> <ul><li><a class="mw-selflink selflink">AIDS</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Central_nervous_system_viral_disease" title="Central nervous system viral disease">Central<br /> nervous system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Viral_encephalitis" title="Viral encephalitis">Encephalitis</a>/<br /><a href="/wiki/Viral_meningitis" title="Viral meningitis">meningitis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></dt> <dd><i><a href="/wiki/Human_polyomavirus_2" title="Human polyomavirus 2">Human polyomavirus 2</a></i> <dl><dd><a href="/wiki/Progressive_multifocal_leukoencephalopathy" title="Progressive multifocal leukoencephalopathy">Progressive multifocal leukoencephalopathy</a></dd></dl></dd></dl> <dl><dt><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></dt> <dd><i><a href="/wiki/Measles_morbillivirus" class="mw-redirect" title="Measles morbillivirus">MeV</a></i> <dl><dd><a href="/wiki/Subacute_sclerosing_panencephalitis" title="Subacute sclerosing panencephalitis">Subacute sclerosing panencephalitis</a></dd></dl></dd> <dd><i><a href="/wiki/Lymphocytic_choriomeningitis" title="Lymphocytic choriomeningitis">LCV</a></i> <dl><dd><a href="/wiki/Lymphocytic_choriomeningitis" title="Lymphocytic choriomeningitis">Lymphocytic choriomeningitis</a></dd></dl></dd> <dd><a href="/wiki/Arbovirus_encephalitis" class="mw-redirect" title="Arbovirus encephalitis">Arbovirus encephalitis</a></dd> <dd><i><a href="/wiki/Orthomyxoviridae" title="Orthomyxoviridae">Orthomyxoviridae</a></i> (probable) <dl><dd><a href="/wiki/Encephalitis_lethargica" title="Encephalitis lethargica">Encephalitis lethargica</a></dd></dl></dd> <dd><i><a href="/wiki/Rabies_virus" title="Rabies virus">RV</a></i> <dl><dd><a href="/wiki/Rabies" title="Rabies">Rabies</a></dd></dl></dd> <dd><a href="/wiki/Chandipura_vesiculovirus" title="Chandipura vesiculovirus">Chandipura vesiculovirus</a></dd> <dd><a href="/wiki/Herpesviral_meningitis" class="mw-redirect" title="Herpesviral meningitis">Herpesviral meningitis</a></dd> <dd><a href="/wiki/Ramsay_Hunt_syndrome_type_2" title="Ramsay Hunt syndrome type 2">Ramsay Hunt syndrome type 2</a></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myelitis" title="Myelitis">Myelitis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Poliovirus" title="Poliovirus">Poliovirus</a></i> <ul><li><a href="/wiki/Polio" title="Polio">Poliomyelitis</a></li> <li><a href="/wiki/Post-polio_syndrome" title="Post-polio syndrome">Post-polio syndrome</a></li></ul></li> <li><i><a href="/wiki/Human_T-lymphotropic_virus_1" title="Human T-lymphotropic virus 1">HTLV-I</a></i> <ul><li><a href="/wiki/Tropical_spastic_paraparesis" title="Tropical spastic paraparesis">Tropical spastic paraparesis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Eye_disease" title="Eye disease">Eye</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Cytomegalovirus" title="Cytomegalovirus">Cytomegalovirus</a></i> <ul><li><a href="/wiki/Cytomegalovirus_retinitis" title="Cytomegalovirus retinitis">Cytomegalovirus retinitis</a></li></ul></li> <li><i><a href="/wiki/Herpes_simplex_virus" title="Herpes simplex virus">HSV</a></i> <ul><li><a href="/wiki/Herpes_simplex_keratitis" title="Herpes simplex keratitis">Herpes of the eye</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cardiovascular_disease" title="Cardiovascular disease">Cardiovascular</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Coxsackie_B_virus" title="Coxsackie B virus">CBV</a></i> <ul><li><a href="/wiki/Pericarditis" title="Pericarditis">Pericarditis</a></li> <li><a href="/wiki/Myocarditis" title="Myocarditis">Myocarditis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Respiratory_system" title="Respiratory system">Respiratory system</a>/<br /><a href="/wiki/Common_cold" title="Common cold">acute viral<br />nasopharyngitis</a>/<br /><a href="/wiki/Viral_pneumonia" title="Viral pneumonia">viral pneumonia</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Epstein%E2%80%93Barr_virus" title="Epstein–Barr virus">Epstein–Barr virus</a></i> <ul><li><a href="/wiki/Epstein%E2%80%93Barr_virus_infection" title="Epstein–Barr virus infection">EBV infection</a>/<a href="/wiki/Infectious_mononucleosis" title="Infectious mononucleosis">Infectious mononucleosis</a></li></ul></li> <li><i><a href="/wiki/Cytomegalovirus" title="Cytomegalovirus">Cytomegalovirus</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RNA_virus#Group_IV_–_positive-sense_ssRNA_viruses" title="RNA virus">IV</a>: <i><a href="/wiki/Human_coronavirus" class="mw-redirect" title="Human coronavirus">Human coronavirus</a> <a href="/wiki/Human_coronavirus_229E" title="Human coronavirus 229E">229E</a>/<a href="/wiki/Human_coronavirus_NL63" title="Human coronavirus NL63">NL63</a>/<a href="/wiki/Human_coronavirus_HKU1" title="Human coronavirus HKU1">HKU1</a>/<a href="/wiki/Human_coronavirus_OC43" title="Human coronavirus OC43">OC43</a></i> <ul><li><a href="/wiki/Common_cold" title="Common cold">Common cold</a></li></ul></li> <li><i><a href="/wiki/Middle_East_respiratory_syndrome%E2%80%93related_coronavirus" class="mw-redirect" title="Middle East respiratory syndrome–related coronavirus">MERS coronavirus</a></i> <ul><li><a href="/wiki/Middle_East_respiratory_syndrome" class="mw-redirect" title="Middle East respiratory syndrome">Middle East respiratory syndrome</a></li></ul></li> <li><i><a href="/wiki/Severe_acute_respiratory_syndrome_coronavirus" class="mw-redirect" title="Severe acute respiratory syndrome coronavirus">SARS coronavirus</a></i> <ul><li><a href="/wiki/Severe_acute_respiratory_syndrome" class="mw-redirect" title="Severe acute respiratory syndrome">Severe acute respiratory syndrome</a></li></ul></li> <li><i><a href="/wiki/SARS-CoV-2" title="SARS-CoV-2">SARS-CoV-2</a></i> <ul><li><a href="/wiki/COVID-19" title="COVID-19">COVID-19</a></li></ul></li></ul> <ul><li><a href="/wiki/RNA_virus#Group_V_–_negative-sense_ssRNA_viruses" title="RNA virus">V</a>, <i><a href="/wiki/Orthomyxoviridae" title="Orthomyxoviridae">Orthomyxoviridae</a></i>: <i><a href="/wiki/Influenza_A_virus" title="Influenza A virus">Influenza virus A</a>/<a href="/wiki/Influenza_B_virus" title="Influenza B virus">B</a>/<a href="/wiki/Influenza_C_virus" title="Influenza C virus">C</a>/<a href="/wiki/Influenza_D_virus" title="Influenza D virus">D</a></i> <ul><li><a href="/wiki/Influenza" title="Influenza">Influenza</a>/<a href="/wiki/Avian_influenza" title="Avian influenza">Avian influenza</a></li></ul></li></ul> <ul><li>V, <i><a href="/wiki/Paramyxoviridae" title="Paramyxoviridae">Paramyxoviridae</a></i>: <i><a href="/wiki/Human_parainfluenza_viruses" title="Human parainfluenza viruses">Human parainfluenza viruses</a></i> <ul><li><a href="/wiki/Human_parainfluenza_viruses" title="Human parainfluenza viruses">Parainfluenza</a></li></ul></li> <li><i><a href="/wiki/Human_orthopneumovirus" class="mw-redirect" title="Human orthopneumovirus">Human orthopneumovirus</a></i></li> <li><i><a href="/wiki/Human_metapneumovirus" title="Human metapneumovirus">hMPV</a></i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Human_digestive_system" title="Human digestive system">Human<br /> digestive system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pharynx" title="Pharynx">Pharynx</a>/<a href="/wiki/Esophagus" title="Esophagus">Esophagus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Mumps_virus" title="Mumps virus">MuV</a></i> <ul><li><a href="/wiki/Mumps" title="Mumps">Mumps</a></li></ul></li> <li><i><a href="/wiki/Cytomegalovirus" title="Cytomegalovirus">Cytomegalovirus</a></i> <ul><li><a href="/wiki/Cytomegalovirus_esophagitis" title="Cytomegalovirus esophagitis">Cytomegalovirus esophagitis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gastroenteritis#Viral" title="Gastroenteritis">Gastroenteritis</a>/<br /><a href="/wiki/Gastroenteritis#Virus" title="Gastroenteritis">diarrhea</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></dt> <dd><i><a href="/wiki/Adenoviridae" title="Adenoviridae">Adenovirus</a></i> <dl><dd><a href="/wiki/Adenovirus_infection" title="Adenovirus infection">Adenovirus infection</a></dd></dl></dd></dl> <dl><dt><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></dt> <dd><i><a href="/wiki/Rotavirus" title="Rotavirus">Rotavirus</a></i> (<a href="/wiki/Rotaviral_gastroenteritis" class="mw-redirect" title="Rotaviral gastroenteritis">Gastroenteritis</a>)</dd> <dd><i><a href="/wiki/Norovirus" title="Norovirus">Norovirus</a></i></dd> <dd><i><a href="/wiki/Astrovirus" title="Astrovirus">Astrovirus</a></i></dd> <dd><i><a href="/wiki/Coronavirus" title="Coronavirus">Coronavirus</a></i></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Viral_hepatitis" title="Viral hepatitis">Hepatitis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <dl><dt><a href="/wiki/DNA_virus" title="DNA virus">DNA virus</a></dt> <dd><i><a href="/wiki/Hepatitis_B_virus" title="Hepatitis B virus">HBV</a></i> (<a href="/wiki/Hepatitis_B" title="Hepatitis B">B</a>)</dd></dl> <dl><dt><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a></dt> <dd><i><a href="/wiki/Coxsackie_B_virus" title="Coxsackie B virus">CBV</a></i></dd> <dd><i><a href="/wiki/Hepatitis_A#Virology" title="Hepatitis A">HAV</a></i> (<a href="/wiki/Hepatitis_A" title="Hepatitis A">A</a>)</dd> <dd><i><a href="/wiki/Hepatitis_C_virus" title="Hepatitis C virus">HCV</a></i> (<a href="/wiki/Hepatitis_C" title="Hepatitis C">C</a>)</dd> <dd><i><a href="/wiki/Hepatitis_D" title="Hepatitis D">HDV</a></i> (<a href="/wiki/Hepatitis_D" title="Hepatitis D">D</a>)</dd> <dd><i><a href="/wiki/Orthohepevirus_A" title="Orthohepevirus A">HEV</a></i> (<a href="/wiki/Hepatitis_E" title="Hepatitis E">E</a>)</dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pancreatitis" title="Pancreatitis">Pancreatitis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Coxsackie_B_virus" title="Coxsackie B virus">CBV</a></i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Genitourinary_system" title="Genitourinary system">Urogenital</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/BK_virus" title="BK virus">BK virus</a></i></li> <li><i><a href="/wiki/Mumps_virus" title="Mumps virus">MuV</a></i> <ul><li><a href="/wiki/Mumps" title="Mumps">Mumps</a></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Lymphoid_and_complement_disorders_causing_immunodeficiency" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Lymphoid_and_complement_immunodeficiency" title="Template:Lymphoid and complement immunodeficiency"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Lymphoid_and_complement_immunodeficiency" title="Template talk:Lymphoid and complement immunodeficiency"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Lymphoid_and_complement_immunodeficiency" title="Special:EditPage/Template:Lymphoid and complement immunodeficiency"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Lymphoid_and_complement_disorders_causing_immunodeficiency" style="font-size:114%;margin:0 4em"><a href="/wiki/Lymphatic_system" title="Lymphatic system">Lymphoid</a> and <a href="/wiki/Complement_system" title="Complement system">complement</a> disorders causing <a href="/wiki/Immunodeficiency" title="Immunodeficiency">immunodeficiency</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Primary_immunodeficiency" title="Primary immunodeficiency">Primary</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antibody" title="Antibody">Antibody</a>/<a href="/wiki/Humoral_immune_deficiency" title="Humoral immune deficiency">humoral</a><br />(<a href="/wiki/B_cell" title="B cell">B</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hypogammaglobulinemia" title="Hypogammaglobulinemia">Hypogammaglobulinemia</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/X-linked_agammaglobulinemia" title="X-linked agammaglobulinemia">X-linked agammaglobulinemia</a></li> <li><a href="/wiki/Transient_hypogammaglobulinemia_of_infancy" title="Transient hypogammaglobulinemia of infancy">Transient hypogammaglobulinemia of infancy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dysgammaglobulinemia" title="Dysgammaglobulinemia">Dysgammaglobulinemia</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Selective_immunoglobulin_A_deficiency" title="Selective immunoglobulin A deficiency">IgA deficiency</a></li> <li><a href="/wiki/IgG_deficiency" title="IgG deficiency">IgG deficiency</a></li> <li><a href="/wiki/Immunoglobulin_M_deficiency" class="mw-redirect" title="Immunoglobulin M deficiency">IgM deficiency</a></li> <li><a href="/wiki/Hyper_IgM_syndrome" title="Hyper IgM syndrome">Hyper IgM syndrome</a> (<a href="/wiki/Hyper-IgM_syndrome_type_1" title="Hyper-IgM syndrome type 1">1</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_2" title="Hyper-IgM syndrome type 2">2</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_3" title="Hyper-IgM syndrome type 3">3</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_4" title="Hyper-IgM syndrome type 4">4</a></li> <li><a href="/wiki/Hyper-IgM_syndrome_type_5" title="Hyper-IgM syndrome type 5">5</a>)</li> <li><a href="/wiki/Wiskott%E2%80%93Aldrich_syndrome" title="Wiskott–Aldrich syndrome">Wiskott–Aldrich syndrome</a></li> <li><a href="/wiki/Hyperimmunoglobulin_E_syndrome" title="Hyperimmunoglobulin E syndrome">Hyper-IgE syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Common_variable_immunodeficiency" title="Common variable immunodeficiency">Common variable immunodeficiency</a></li> <li><a href="/wiki/ICF_syndrome" class="mw-redirect" title="ICF syndrome">ICF syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/T_cell_deficiency" title="T cell deficiency">T cell deficiency</a><br />(<a href="/wiki/T_cell" title="T cell">T</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Thymic_hypoplasia" title="Thymic hypoplasia">thymic hypoplasia</a>:</i> <i>hypoparathyroid</i> (<a href="/wiki/DiGeorge_syndrome" title="DiGeorge syndrome">Di George's syndrome</a>)</li> <li><i>euparathyroid</i> (<a href="/wiki/Nezelof_syndrome" title="Nezelof syndrome">Nezelof syndrome</a></li> <li><a href="/wiki/Ataxia%E2%80%93telangiectasia" title="Ataxia–telangiectasia">Ataxia–telangiectasia</a>)</li></ul> <p><i>peripheral:</i> <a href="/wiki/Purine_nucleoside_phosphorylase_deficiency" title="Purine nucleoside phosphorylase deficiency">Purine nucleoside phosphorylase deficiency</a> </p> <ul><li><a href="/wiki/Hyper_IgM_syndrome" title="Hyper IgM syndrome">Hyper IgM syndrome</a> (<a href="/wiki/Hyper-IgM_syndrome_type_1" title="Hyper-IgM syndrome type 1">1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Severe_combined_immunodeficiency" title="Severe combined immunodeficiency">Severe</a> <a href="/wiki/Combined_immunodeficiencies" title="Combined immunodeficiencies">combined</a><br />(B+T)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>x-linked:</i> <a href="/wiki/X-linked_severe_combined_immunodeficiency" title="X-linked severe combined immunodeficiency">X-SCID</a><br /><i>autosomal:</i> <a href="/wiki/Adenosine_deaminase_deficiency" title="Adenosine deaminase deficiency">Adenosine deaminase deficiency</a></li> <li><a href="/wiki/Omenn_syndrome" title="Omenn syndrome">Omenn syndrome</a></li> <li><a href="/wiki/ZAP70_deficiency" title="ZAP70 deficiency">ZAP70 deficiency</a></li> <li><a href="/wiki/Bare_lymphocyte_syndrome" title="Bare lymphocyte syndrome">Bare lymphocyte syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunodeficiency#acquired" title="Immunodeficiency">Acquired</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">HIV/AIDS</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukopenia" title="Leukopenia">Leukopenia</a>:<br /><a href="/wiki/Lymphocytopenia" title="Lymphocytopenia">Lymphocytopenia</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Idiopathic_CD4%2B_lymphocytopenia" title="Idiopathic CD4+ lymphocytopenia">Idiopathic CD4+ lymphocytopenia</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Complement_deficiency" title="Complement deficiency">Complement<br />deficiency</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/C1-inhibitor" title="C1-inhibitor">C1-inhibitor</a></i> (<a href="/wiki/Angioedema" title="Angioedema">Angioedema</a>/<a href="/wiki/Hereditary_angioedema" title="Hereditary angioedema">Hereditary angioedema</a>)</li> <li><a href="/wiki/Complement_2_deficiency" title="Complement 2 deficiency">Complement 2 deficiency</a>/<a href="/wiki/Complement_4_deficiency" title="Complement 4 deficiency">Complement 4 deficiency</a></li> <li><a href="/wiki/MBL_deficiency" title="MBL deficiency">MBL deficiency</a></li> <li><a href="/wiki/Properdin_deficiency" title="Properdin deficiency">Properdin deficiency</a></li> <li><a href="/wiki/Complement_3_deficiency" title="Complement 3 deficiency">Complement 3 deficiency</a></li> <li><a href="/wiki/Terminal_complement_pathway_deficiency" title="Terminal complement pathway deficiency">Terminal complement pathway deficiency</a></li> <li><a href="/wiki/Paroxysmal_nocturnal_hemoglobinuria" title="Paroxysmal nocturnal hemoglobinuria">Paroxysmal nocturnal hemoglobinuria</a></li> <li><a href="/wiki/Complement_receptor_deficiency" class="mw-redirect" title="Complement receptor deficiency">Complement receptor deficiency</a></li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 0;column-gap:1em;align-items:baseline;margin:0;list-style:none}.mw-parser-output .portal-bar-content-related{margin:0;list-style:none}.mw-parser-output .portal-bar-item{display:inline-block;margin:0.15em 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.portal-bar+.navbox-styles+.sister-bar{margin-top:-1px}</style><div class="portal-bar noprint metadata noviewer portal-bar-bordered" role="navigation" aria-label="Portals"><span class="portal-bar-header"><a href="/wiki/Wikipedia:Contents/Portals" title="Wikipedia:Contents/Portals">Portals</a>:</span><ul class="portal-bar-content"><li class="portal-bar-item"><span class="nowrap"><span typeof="mw:File"><a href="/wiki/File:Sida-aids.png" class="mw-file-description"><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Sida-aids.png/19px-Sida-aids.png" decoding="async" width="19" height="19" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Sida-aids.png/29px-Sida-aids.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Sida-aids.png/38px-Sida-aids.png 2x" data-file-width="290" data-file-height="290" /></a></span> </span><a href="/wiki/Portal:Viruses" title="Portal:Viruses">Viruses</a></li><li class="portal-bar-item"><span class="nowrap"><span typeof="mw:File"><span><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/8px-WHO_Rod.svg.png" decoding="async" width="8" height="19" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/12px-WHO_Rod.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/16px-WHO_Rod.svg.png 2x" data-file-width="107" data-file-height="250" /></span></span> </span><a href="/wiki/Portal:Medicine" title="Portal:Medicine">Medicine</a></li></ul></div><style data-mw-deduplicate="TemplateStyles:r1236088147">.mw-parser-output .sister-bar{display:flex;justify-content:center;align-items:baseline;font-size:88%;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em 0 0;padding:0 2em}.mw-parser-output .sister-bar-header{margin:0 1em 0 0.5em;padding:0.2em 0;flex:0 0 auto;min-height:24px;line-height:22px}.mw-parser-output .sister-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;align-items:baseline;padding:0.2em 0;column-gap:1em;margin:0;list-style:none}.mw-parser-output .sister-bar-item{display:flex;align-items:baseline;margin:0.15em 0;min-height:24px;text-align:left}.mw-parser-output .sister-bar-logo{width:22px;line-height:22px;margin:0 0.2em;text-align:right}.mw-parser-output .sister-bar-link{margin:0 0.2em;text-align:left}@media screen and (max-width:960px){.mw-parser-output .sister-bar{flex-flow:column wrap;margin:1em auto 0}.mw-parser-output .sister-bar-header{flex:0 1}.mw-parser-output .sister-bar-content{flex:1;border-top:1px solid #a2a9b1;margin:0;list-style:none}.mw-parser-output .sister-bar-item{flex:0 0 20em;min-width:20em}}.mw-parser-output .navbox+link+.sister-bar,.mw-parser-output .navbox+style+.sister-bar,.mw-parser-output .portal-bar+link+.sister-bar,.mw-parser-output .portal-bar+style+.sister-bar,.mw-parser-output .sister-bar+.navbox-styles+.navbox,.mw-parser-output .sister-bar+.navbox-styles+.portal-bar{margin-top:-1px}@media print{body.ns-0 .mw-parser-output .sister-bar{display:none!important}}</style><div class="noprint metadata sister-bar" role="navigation" aria-label="sister-projects"><div class="sister-bar-header"><b>HIV/AIDS</b> at Wikipedia's <a href="/wiki/Wikipedia:Wikimedia_sister_projects" title="Wikipedia:Wikimedia sister projects"><span id="sister-projects" style="white-space:nowrap;">sister projects</span></a>:</div><ul class="sister-bar-content"><li class="sister-bar-item"><span class="sister-bar-logo"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/0/06/Wiktionary-logo-v2.svg/19px-Wiktionary-logo-v2.svg.png" decoding="async" width="19" height="19" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/0/06/Wiktionary-logo-v2.svg/29px-Wiktionary-logo-v2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/0/06/Wiktionary-logo-v2.svg/38px-Wiktionary-logo-v2.svg.png 2x" data-file-width="391" data-file-height="391" /></span></span></span><span class="sister-bar-link"><b><a href="https://en.wiktionary.org/wiki/Special:Search/HIV/AIDS" class="extiw" title="wikt:Special:Search/HIV/AIDS">Definitions</a></b> from Wiktionary</span></li><li class="sister-bar-item"><span class="sister-bar-logo"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/14px-Commons-logo.svg.png" decoding="async" width="14" height="19" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/21px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/28px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></span></span></span><span class="sister-bar-link"><b><a href="https://commons.wikimedia.org/wiki/AIDS" class="extiw" title="c:AIDS">Media</a></b> from Commons</span></li><li class="sister-bar-item"><span class="sister-bar-logo"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Wikinews-logo.svg/21px-Wikinews-logo.svg.png" decoding="async" width="21" height="11" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Wikinews-logo.svg/32px-Wikinews-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/24/Wikinews-logo.svg/42px-Wikinews-logo.svg.png 2x" data-file-width="759" data-file-height="415" /></span></span></span><span class="sister-bar-link"><b><a href="https://en.wikinews.org/wiki/Category:AIDS" class="extiw" title="n:Category:AIDS">News</a></b> from Wikinews</span></li><li class="sister-bar-item"><span class="sister-bar-logo"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Wikiquote-logo.svg/16px-Wikiquote-logo.svg.png" decoding="async" width="16" height="19" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Wikiquote-logo.svg/24px-Wikiquote-logo.svg.png 1.5x, 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databases</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q12199#identifiers" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">International</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul><li><span class="uid"><a rel="nofollow" class="external text" href="http://id.worldcat.org/fast/793808/">FAST</a></span></li></ul></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">National</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul><li><span class="uid"><a rel="nofollow" class="external text" href="https://d-nb.info/gnd/4112470-4">Germany</a></span></li><li><span class="uid"><span class="rt-commentedText tooltip tooltip-dotted" title="AIDS (Disease)"><a rel="nofollow" class="external text" href="https://id.loc.gov/authorities/sh85002541">United States</a></span></span></li><li><span class="uid"><a rel="nofollow" class="external text" href="https://catalogue.bnf.fr/ark:/12148/cb11975352k">France</a></span></li><li><span class="uid"><a rel="nofollow" class="external text" href="https://data.bnf.fr/ark:/12148/cb11975352k">BnF data</a></span></li><li><span class="uid"><a rel="nofollow" class="external text" href="https://id.ndl.go.jp/auth/ndlna/00575858">Japan</a></span></li><li><span class="uid"><span class="rt-commentedText tooltip tooltip-dotted" title="AIDS"><a rel="nofollow" class="external text" href="https://aleph.nkp.cz/F/?func=find-c&amp;local_base=aut&amp;ccl_term=ica=ph117300&amp;CON_LNG=ENG">Czech Republic</a></span></span></li><li><span class="uid"><a rel="nofollow" class="external text" href="http://catalogo.bne.es/uhtbin/authoritybrowse.cgi?action=display&amp;authority_id=XX527488">Spain</a></span></li><li><span class="uid"><a rel="nofollow" class="external text" href="http://olduli.nli.org.il/F/?func=find-b&amp;local_base=NLX10&amp;find_code=UID&amp;request=987007294774305171">Israel</a></span></li></ul></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul><li><span class="uid"><a rel="nofollow" class="external text" href="https://hls-dhs-dss.ch/fr/articles/025625">Historical Dictionary of Switzerland</a></span></li></ul></div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.codfw.main‐f69cdc8f6‐zdfpm Cached time: 20241122141906 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 3.372 seconds Real time usage: 3.674 seconds Preprocessor visited node count: 22339/1000000 Post‐expand include size: 932606/2097152 bytes Template argument size: 12312/2097152 bytes Highest expansion depth: 15/100 Expensive parser function count: 43/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 1350112/5000000 bytes Lua time usage: 2.065/10.000 seconds Lua memory usage: 22633378/52428800 bytes Lua Profile: ? 340 ms 15.7% MediaWiki\Extension\Scribunto\Engines\LuaSandbox\LuaSandboxCallback::callParserFunction 280 ms 13.0% dataWrapper <mw.lua:672> 220 ms 10.2% MediaWiki\Extension\Scribunto\Engines\LuaSandbox\LuaSandboxCallback::find 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