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as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented. </p> </div> </div> </div> </div> <div class="pdp-components"> <div id="pdp-components" ng-controller="pdpMainController as $ctrl">  <div block-ui="main" class="block-ui-main"></div> <div class="hero hero-loading-height" ng-class="{'is-loaded':$ctrl.isLoaded, 'with-banner': 'false' == 'true'}"> <div class="container"> <div class="hero-content"> <div class="brand-breadcrumb to-hide-on-mobile row"> <div class="large-span-12 medium-span-12 target_page_breadcrumbs"> <div class="breadcrumb breadcrumb-hide-restricted-only"> <ul class="breadcrumb breadcrumb-hide-restricted-only hero-breadcrumbs"> <li class="active"> <a href="/us/en/home/life-science/antibodies/primary-antibodies.html" target="_self"> Primary Antibodies </a> <span class="divider">&rsaquo;</span> </li> <li class="active"> <a href="/antibody/primary/target/gapdh" target="_self" class="targetLink"> GAPDH Antibodies</a> </li> </ul> </div> </div> </div> <svg xmlns="http://www.w3.org/2000/svg" display="none"> <symbol id="close-drawer-icon" viewBox="0 0 22.74 22.74"> <line x1="1.67" y1="1.67" x2="21.33" y2="21.33" style="fill:none;stroke:#555759;stroke-linecap:square;stroke-width:2px"/> <line x1="21.07" y1="1.41" x2="1.41" y2="21.07" style="fill:none;stroke:#555759;stroke-linecap:square;stroke-width:2px"/> </symbol> <symbol id="info-icon" viewBox="0 0 32 32"> <path fill="#1e8ae7" d="M16 10.688c-1.152 0-2.048-0.896-2.048-2.048s0.896-2.048 2.048-2.048c1.152 0 2.048 0.896 2.048 2.048 0 1.088-0.96 2.048-2.048 2.048zM17.792 22.976c0 0.768-0.064 1.152-0.256 1.536-0.256 0.576-0.832 0.896-1.6 0.896-0.704 0-1.28-0.32-1.6-0.896-0.192-0.384-0.256-0.768-0.256-1.536v-8.256c0-0.768 0.064-1.152 0.256-1.536 0.256-0.576 0.832-0.896 1.6-0.896 0.704 0 1.28 0.32 1.6 0.896 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class="details-hero"> <a class="link references-link animated-scroll " href="#references-component-id" onclick="window.THERMO_FISHER.pdp.inp.referencesHero(event, this)"> <svg class="svg-icon references-icon"> <use href="#icon-references"></use> </svg> 681 References </a> </div> <div class="details-hero"> <a class="btn hero-btn hero-view-other" href="/antibody/primary/target/gapdh"> View all (105) GAPDH antibodies </a> </div> </div> <div class="links-ab to-show-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=AM4300&version=Local" target="_blank" rel="nofollow"> <span> <svg class="svg-icon data-sheet-icon"> <use href="#icon-data-sheet"></use> </svg> </span> Datasheet </a> </div> <div class="link-container"> <a href="https://www.thermofisher.com/global/en/home/life-science/antibodies/antibodies-learning-center/antibody-protocols.html?icid=antibody-pdp-protocols" target="_blank" class="link-antibody"> <span> <svg class="svg-icon protocols-icon"> <use href="#icon-protocols"></use> </svg> </span> Protocols </a> </div> <div class="link-container"> <a href="/us/en/home/technical-resources/contact-us.AM4300.html?supportType=TS" class="link-antibody"> <span> <svg class="svg-icon tech-support-icon"> <use href="#icon-tech-support"></use> </svg> </span> Tech Support </a> </div> </div> </div> <div class="cmrc-card-cnt" id="antibody_primary"> <div class="price-card-alignmnet" tf-product-order> <aside class="sidecard"> <div ng-switch on="$productOrderCtrl.isMultiPack()"> <div ng-switch-when="true"> <div ng-include="$productOrderCtrl.getTemplatePath()+'product-order-multipack.template.html'"></div> </div> <div ng-switch-default> <div 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Data':[{'sku':'AM4300','imageId':'59152','imageUrl':'https://www.thermofisher.com/antibody/images/650/AM4300-GAPDH-IF.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/AM4300-GAPDH-IF.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/AM4300-GAPDH-IF.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/AM4300-GAPDH-IF.jpg?time\u003d20240507','sortOrder':'1','description':'Immunofluorescence analysis of GAPDH was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with GAPDH Mouse Monoclonal Antibody (Product # AM4300) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). F-actin (Panel c: red) was stained with Alexa Fluor® 555 Rhodamine Phalloidin (Product # R415, 1:300). Panel d is a merged image showing perinuclear and cytoplasmic localization. Panel e is a no primary antibody control. The images were captured at 60X magnification.','shortDescription':'Immunofluorescence analysis of GAPDH was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with GAPDH Mouse Monoclonal Antibody (Product # AM4300) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'GAPDH Antibody in Immunocytochemistry (ICC/IF)','title':'GAPDH Antibody (AM4300) in ICC/IF','appAbv':'ICC/IF','appName':'Immunocytochemistry','type':'Antibody Testing Data','journalText':'','sourceType':'1','benchsci':false,'imageName':'AM4300-GAPDH-IF.jpg','benchSciPubmedId':'0'},{'sku':'AM4300','imageId':'2438','imageUrl':'https://www.thermofisher.com/antibody/images/650/AM4300-f00634.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/AM4300-f00634.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/AM4300-f00634.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/AM4300-f00634.jpg?time\u003d20240507','sortOrder':'2','description':'An siRNA targeting ß-actin was labeled with Cy™3 using the Silencer™ siRNA Labeling Kit. The labeled siRNA was transfected into HeLa cells and cells were analyzed 96 hours later. Green: ß-actin protein detected with anti-ß-actin (Ambion) and a FITC labeled secondary antibody. Red: Cy3 labeled siRNA. Blue: DAPI stained nuclei. (Cy™3 is a trademark of Amersham Biosciences.)','shortDescription':'An siRNA targeting ß-actin was labeled with Cy™3 using the Silencer™ siRNA Labeling Kit. The labeled siRNA was transfected into HeLa cells and cells were analyzed 96 hours later. Green: ß-actin protein detected with anti-ß-actin (Ambion) and a FITC labeled secondary antibody. Red: Cy3 labeled siRNA. Blue: DAPI stained nuclei. (Cy™3 is a trademark of Amersham Biosciences.)','altTag':'GAPDH Antibody in Immunocytochemistry (ICC/IF)','title':'GAPDH Antibody (AM4300) in ICC/IF','appAbv':'ICC/IF','appName':'Immunocytochemistry','type':'Antibody Testing Data','journalText':'','sourceType':'1','benchsci':false,'imageName':'AM4300-f00634.jpg','benchSciPubmedId':'0'},{'sku':'AM4300','imageId':'126561','imageUrl':'https://www.thermofisher.com/antibody/images/650/AM4300-ANTI-GAPDH-MAB100UG-WB-20170510104001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/AM4300-ANTI-GAPDH-MAB100UG-WB-20170510104001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/AM4300-ANTI-GAPDH-MAB100UG-WB-20170510104001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/AM4300-ANTI-GAPDH-MAB100UG-WB-20170510104001.jpg?time\u003d20240507','sortOrder':'3','description':'Western blot analysis was performed on whole cell extracts (30µg lysate) of SH-SY5Y (Lane 1), COS-7 (Lane 2), MDCK (Lane 3), C2C12 (Lane 4), PC-3 (Lane 5), PC-12 (Lane 6), Neuro-2a (Lane 7), tissue extracts of Mouse Brain (Lane 8), Rat Testis (Lane 9), Mouse Pancreas (Lane 10) and Rat Heart (Lane 11). The blot was probed with Anti-GAPDH Mouse Monoclonal Antibody (Product # AM4300, 2µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25µg/mL, 1:500 dilution). A 37 kDa band corresponding to GAPDH was observed across the cell lines and tissues tested. Known quantity of protein samples were electrophoresed using Novex® NuPAGE®12 % Bis-Tris gel (Product # NP0342BOX), XCell SureLock™ Electrophoresis System (Product # EI0002) and Novex® Sharp Pre-Stained Protein Standard (Product # LC5800). Resolved proteins were then transferred onto a nitrocellulose membrane with iBlot® 2 Dry Blotting System (Product # IB21001). The membrane was probed with the relevant primary and secondary Antibody following blocking with 5 % skimmed milk. Chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).','shortDescription':'Western blot analysis was performed on whole cell extracts (30µg lysate) of SH-SY5Y (Lane 1), COS-7 (Lane 2), MDCK (Lane 3), C2C12 (Lane 4), PC-3 (Lane 5), PC-12 (Lane 6), Neuro-2a (Lane 7), tissue extracts of Mouse Brain (Lane 8), Rat Testis (Lane 9), Mouse Pancreas (Lane 10) and Rat Heart (Lane 11). The blot was probed with Anti-GAPDH Mouse Monoclonal Antibody (Product # AM4300, 2µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25µg/mL, 1:500 dilu... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'GAPDH Antibody in Western Blot (WB)','title':'GAPDH Antibody (AM4300) in WB','appAbv':'WB','appName':'Western Blot','type':'Antibody Testing Data','journalText':'','sourceType':'1','benchsci':false,'imageName':'AM4300-ANTI-GAPDH-MAB100UG-WB-20170510104001.jpg','benchSciPubmedId':'0'}],'Published Figures':[],'Advanced Verification':[]}" image-displayed-id="'59152'" product-sub-type="'antibody_primary'" prod-type="'antibody'" page-type="PDP" product-id="'AM4300'"> <div class="tabs"> <ul class="nav nav-pills"> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Antibody Testing Data"> <a class="tab-text"> 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<desc>Created with Sketch.</desc> <g id="Symbols"> <g id="rollover-expand-icon" transform="translate(-8.000000, -8.000000)"> <g id="Group-48"> <g id="Group-53" transform="translate(8.000000, 8.000000)"> <g id="Group-49" transform="translate(0.000000, 0.000000)"> <g id="Group-54"> <g id="Group-55" transform="translate(0.000000, -0.000000)"> <path id="Fill-1" class="st0" d="M21.9,14.6h-2.2c0,1,0,1.9,0,2.9c0,0.2,0,0.4,0,0.6c-0.1-0.1-0.2-0.2-0.3-0.2 c-1.3-1.3-2.7-2.7-4-4l-1.6,1.5c1.3,1.4,2.7,2.7,4,4.1c0.1,0.1,0.1,0.2,0.3,0.3c-0.2,0-0.3,0-0.4,0c-1,0-2.1,0-3.1,0V22 c2.3,0,4.8,0,7.1,0.1c0.1,0,0.2,0,0.3,0c0-0.5-0.1-0.9-0.1-1.3C21.9,18.7,21.9,16.6,21.9,14.6z"/> <path id="Fill-4" class="st0" d="M1.3,21.9c1.9,0,4,0,6,0v-2.2c-1,0-1.9,0-2.9,0c-0.2,0-0.4,0-0.6,0C3.9,19.6,4,19.5,4,19.4 c1.3-1.3,2.7-2.7,3.9-4l-1.5-1.6c-1.3,1.3-2.7,2.7-4,4c-0.1,0.1-0.2,0.1-0.3,0.3c0-0.2,0-0.3,0-0.4c0-1,0-2.1,0-3.1h-2.2 c0,2.3,0,4.7-0.1,7c0,0.1,0,0.2,0,0.3C0.5,21.9,0.9,21.9,1.3,21.9"/> <path id="Fill-7" class="st0" 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$ctrl.currentElement.advancedVerification.text }}</div> </div> <h2 class="product-name" ng-show="!$ctrl.isVideo"> GAPDH Antibody (AM4300) in ICC/IF </h2> <div ng-show="!$ctrl.isVideo"> <div class="image-desc"> <div class="product-desc-text viewing-more-long-description"> <span class="image-journal-text" > </span> <span class="short-desc"> Immunofluorescence analysis of GAPDH was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with GAPDH Mouse Monoclonal Antibody (Product # AM4300) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution ... <a href="#" class="images-view-more-text" >View More</a> </span> <span class="verification-info hide" ng-if="$ctrl.hasVerificationMethod"> <a rel="nofollow" ng-href="{{$ctrl.currentElement.advancedVerification.uri}}" >{{ $ctrl.currentElement.advancedVerification.fullName }} validation info.</a> </span> <a href="#" class="images-view-more-text hide" ng-if="$ctrl.showViewMore" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)"> View more </a> </div> </div> <div class="img-desc-footer"> <div class="benchsci-pubmed-footer"> <div ng-cloak ng-if="$ctrl.currentElement.benchsci || $ctrl.sourceType === '3'" class="images-benchsci-footer"> <div class="images-benchsci-link" tabindex="0"> <span>Published figure supplied by</span> <span class="icon-benchsci-logo"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 89.75 23.21"><defs><style>.cls-1{fill:#222222;}</style></defs><title>benchsci-logo</title><g id="logo-blue-copy-3"><g id="logo-blue-copy-2"><path id="path14" class="cls-1" d="M34.54,11.49a2.45,2.45,0,0,0,1.59-2.34c0-1.69-1.21-2.94-3.32-2.94H28.88v10.9h4.21a3.06,3.06,0,0,0,3.37-3A2.57,2.57,0,0,0,34.54,11.49ZM31,8h1.49c1,0,1.57.53,1.57,1.36a1.36,1.36,0,0,1-1.55,1.37H31Zm1.72,7.35H31V12.47h1.75a1.42,1.42,0,0,1,1.62,1.46C34.34,14.79,33.72,15.34,32.69,15.34Z"/><path id="path16" class="cls-1" d="M41.34,9.32a3.8,3.8,0,0,0-3.72,4,3.83,3.83,0,0,0,3.91,4.05A3.39,3.39,0,0,0,45,15l-1.71-.51a1.67,1.67,0,0,1-1.72,1.15,1.85,1.85,0,0,1-1.91-1.73H45s0-.34,0-.63C45.09,10.81,43.69,9.32,41.34,9.32Zm-1.66,3.15A1.63,1.63,0,0,1,41.37,11a1.52,1.52,0,0,1,1.69,1.49Z"/><path id="path18" class="cls-1" d="M50.58,9.35a2.48,2.48,0,0,0-2.18,1.14v-1h-2v7.57h2.05V12.75a1.42,1.42,0,0,1,1.41-1.57,1.34,1.34,0,0,1,1.4,1.52v4.42h2V12.35C53.32,10.68,52.46,9.35,50.58,9.35Z"/><path id="path20" class="cls-1" d="M58.2,15.47a1.94,1.94,0,0,1-1.94-2.14,1.92,1.92,0,0,1,1.91-2.12,1.64,1.64,0,0,1,1.67,1.27l1.83-.61a3.45,3.45,0,0,0-3.55-2.55,3.83,3.83,0,0,0-2.82,1.16,3.88,3.88,0,0,0-1.1,2.85,3.9,3.9,0,0,0,4,4,3.5,3.5,0,0,0,3.53-2.55l-1.8-.6A1.72,1.72,0,0,1,58.2,15.47Z"/><path id="path22" class="cls-1" d="M67,9.35a2.72,2.72,0,0,0-2.07.83V6h-2V17.12h2V12.67a1.43,1.43,0,0,1,1.42-1.48,1.34,1.34,0,0,1,1.4,1.53v4.41h2V12.35A2.67,2.67,0,0,0,67,9.35Z"/><path id="path24" class="cls-1" d="M75.82,11.05l-1.63-.35a1.58,1.58,0,0,1-1.4-1.59A1.93,1.93,0,0,1,74.9,7.3a2.21,2.21,0,0,1,2.3,1.86l1.36-.48a3.73,3.73,0,0,0-7.29.54,3,3,0,0,0,2.67,3l1.55.33c1.09.24,1.63.91,1.63,1.7,0,.95-.74,1.74-2.25,1.74a2.51,2.51,0,0,1-1.79-.63,2.45,2.45,0,0,1-.82-1.71l-1.45.46a3.79,3.79,0,0,0,4.08,3.24c2.32,0,3.76-1.52,3.76-3.22C78.65,12.59,77.63,11.45,75.82,11.05Z"/><path id="path26" class="cls-1" d="M83.25,16A2.33,2.33,0,0,1,81,13.41a2.31,2.31,0,0,1,2.24-2.59,1.93,1.93,0,0,1,2,1.57l1.31-.55a3.22,3.22,0,0,0-3.29-2.35,3.7,3.7,0,0,0-3.72,3.92,3.75,3.75,0,0,0,3.74,3.94A3.41,3.41,0,0,0,86.59,15l-1.28-.55A2,2,0,0,1,83.25,16Z"/><path id="path28" class="cls-1" d="M88.69,5.89a1,1,0,1,0,.75.29A1,1,0,0,0,88.69,5.89Z"/><polygon id="rect30" class="cls-1" points="87.99 9.72 89.42 9.72 89.42 17.11 87.99 17.11 87.99 9.72"/><path id="path32" class="cls-1" d="M14.58,8.87A4.1,4.1,0,0,0,15.8,6H14.31a2.62,2.62,0,0,1-.76,1.87L11.66,9.7l-2-2A2.61,2.61,0,0,1,9,6H7.53A4.09,4.09,0,0,0,8.74,8.87l1.87,1.87L8.74,12.61a4.08,4.08,0,0,0-1.21,2.92v2.29H9.18V16.73h1.66v1.09h1.64V16.73h1.65v1.09H15.8V15.53a4.11,4.11,0,0,0-1.21-2.92l-1.38-1.36-1,1.05,1.37,1.36a2.63,2.63,0,0,1,.77,1.58H9a2.68,2.68,0,0,1,.76-1.58Z"/><path id="path34" class="cls-1" d="M11.61,23.21a11.61,11.61,0,1,1,11.6-11.6A11.6,11.6,0,0,1,11.61,23.21Zm0-21.89A10.29,10.29,0,1,0,21.9,11.61,10.28,10.28,0,0,0,11.61,1.32Z"/></g></g></svg> </span> <span id="bechsci-tooltip-{{$ctrl.productId}}" class="bechsci-tooltip-icon" data-toggle="tooltip" ng-click="$ctrl.showBechSciTooltip()" close-tooltip="$ctrl.closeBechSciTooltip()" data-html="true" title="Clicking this link will redirect you to the <a href='https://www.benchsci.com/' target='_blank'> BenchSci</a> website that provides third-party scientific content. 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The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with GAPDH Mouse Monoclonal Antibody (Product # AM4300) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). F-actin (Panel c: red) was stained with Alexa Fluor® 555 Rhodamine Phalloidin (Product # R415, 1:300). Panel d is a merged image showing perinuclear and cytoplasmic localization. Panel e is a no primary antibody control. The images were captured at 60X magnification.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/AM4300-f00634.jpg?time=20240507?time=20240507" alt="GAPDH Antibody in Immunocytochemistry (ICC/IF)" title="GAPDH Antibody (AM4300) in ICC/IF"> <figcaption itemprop="caption">An siRNA targeting ß-actin was labeled with Cy™3 using the Silencer™ siRNA Labeling Kit. The labeled siRNA was transfected into HeLa cells and cells were analyzed 96 hours later. Green: ß-actin protein detected with anti-ß-actin (Ambion) and a FITC labeled secondary antibody. Red: Cy3 labeled siRNA. Blue: DAPI stained nuclei. (Cy™3 is a trademark of Amersham Biosciences.)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/AM4300-ANTI-GAPDH-MAB100UG-WB-20170510104001.jpg?time=20240507?time=20240507" alt="GAPDH Antibody in Western Blot (WB)" title="GAPDH Antibody (AM4300) in WB"> <figcaption itemprop="caption">Western blot analysis was performed on whole cell extracts (30µg lysate) of SH-SY5Y (Lane 1), COS-7 (Lane 2), MDCK (Lane 3), C2C12 (Lane 4), PC-3 (Lane 5), PC-12 (Lane 6), Neuro-2a (Lane 7), tissue extracts of Mouse Brain (Lane 8), Rat Testis (Lane 9), Mouse Pancreas (Lane 10) and Rat Heart (Lane 11). The blot was probed with Anti-GAPDH Mouse Monoclonal Antibody (Product # AM4300, 2µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25µg/mL, 1:500 dilution). A 37 kDa band corresponding to GAPDH was observed across the cell lines and tissues tested. Known quantity of protein samples were electrophoresed using Novex® NuPAGE®12 % Bis-Tris gel (Product # NP0342BOX), XCell SureLock™ Electrophoresis System (Product # EI0002) and Novex® Sharp Pre-Stained Protein Standard (Product # LC5800). Resolved proteins were then transferred onto a nitrocellulose membrane with iBlot® 2 Dry Blotting System (Product # IB21001). The membrane was probed with the relevant primary and secondary Antibody following blocking with 5 % skimmed milk. Chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>AM4300</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Western Blot (WB)</h2></div> <div class="product-item "> <span class="dilution-lbl">3 µg/mL</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#WB-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 633 publications</span> <span class="mobile-view">633 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (IHC)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHC-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 5 publications</span> <span class="mobile-view">5 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Paraffin) (IHC (P))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCP-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunocytochemistry (ICC/IF)</h2></div> <div class="product-item "> <span class="dilution-lbl">1 µg/mL</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ICCIF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 7 publications</span> <span class="mobile-view">7 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunoprecipitation (IP)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IP-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Functional Assay (Functional)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Functional-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Control (Ctrl)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Ctrl-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Dot blot (DB)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#DB-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Miscellaneous PubMed (Misc)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Misc-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 30 publications</span> <span class="mobile-view">30 publications</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Amphibia">Amphibian,</span> <span title="Canis familiaris">Dog,</span> <span title="Gallus gallus">Chicken,</span> <span title="Hyperotreti">Fish,</span> <span title="Homo sapiens">Human,</span> <span title="Mus musculus">Mouse,</span> <span title="Primate">Non-human primate,</span> <span title="Oryctolagus cuniculus">Rabbit,</span> <span title="Rattus">Rat</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>Amphibian,</span> <span>Bovine,</span> <span>C. elegans,</span> <span>Chicken,</span> <span>Dog,</span> <span>Fruit fly,</span> <span>Hamster,</span> <span>Human,</span> <span>Insect,</span> <span>Mouse,</span> <span>Nematode,</span> <span>Non-human primate,</span> <span>Pig,</span> <span>Rat,</span> <span>Xenopus,</span> <span>Yeast,</span> <span>Zebrafish</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Mus musculus">Mouse / IgG1</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 6C5 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Immunogen </h2> </div> <div class="product-item left-flex-cls">Purified rabbit muscle GAPDH (whole molecule). <script type="text/javascript"> if (typeof window.$mangular === 'undefined' 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d="M15,14.9l2.8-2.8L15,9.3c0,0,0,0.9,0,1.9h-13V13h13C15.1,14,15.1,14.9,15,14.9z"/> <path d="M4.9,19.3l-2.8-2.8l2.8-2.8c0,0,0,0.9,0,1.9h13v1.8h-13C4.9,18.4,4.9,19.3,4.9,19.3z"/> </g> <g> <path d="M15.4,3.4"/> <path d="M15,6l2.8-2.8L15,0.3c0,0,0,0.9,0,1.9h-13V4h13C15.1,5.1,15.1,5.9,15,6z"/> <path d="M4.9,10.4L2.1,7.6l2.8-2.8c0,0,0,0.9,0,1.9h13v1.8h-13C4.9,9.5,4.9,10.4,4.9,10.4z"/> </g> <g> <path d="M2.8,8.1C1.3,8.1,0,6.9,0,5.4s1.3-2.7,2.8-2.7v1C1.8,3.6,1,4.4,1,5.4s0.8,1.8,1.8,1.8V8.1z"/> </g> <g> <path d="M17.2,12.6c1.5,0,2.8-1.2,2.8-2.8s-1.3-2.8-2.8-2.8v1c1,0,1.8,0.8,1.8,1.8s-0.8,1.8-1.8,1.8V12.6z"/> </g> <g> <path d="M2.8,17.1c-1.5,0-2.8-1.2-2.8-2.8s1.3-2.8,2.8-2.8v1c-1,0-1.8,0.8-1.8,1.8s0.8,1.8,1.8,1.8V17.1z"/> </g> </g> <g id="Layer_1_copy"> <path class="st1" d="M17.4,12.5c1.4-0.1,2.6-1.3,2.6-2.7c0-1.3-0.9-2.4-2.1-2.7V6.7h-13c0-1.1,0-1.9,0-1.9L2.6,7.1 C1.7,7,1,6.3,1,5.4C1,4.6,1.5,4,2.1,3.7V4h13c0,1,0,1.9,0,1.9l2.8-2.8L15,0.3c0,0,0,0.9,0,1.9h-13v0.4C0.9,3,0,4.1,0,5.4 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class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Protein A </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS, pH 7.4 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.1% sodium azide </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Dry ice </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_2536381</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'AM4300'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-3" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="681" sub-type="'Antibody'" 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itemprop="author">Kang C,Jia L,Hao L,Zhang N,Liu Y,Zhang L</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that POM121 has the potential to act as an independent prognostic factor for GC patients.</div> <div itemprodp="datePublished">Sat Mar 11 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37486931"> <div itemprop="name">Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Packard JE,Williams MR,Fromuth DP,Dembowski JA</div> <div itemprop="description">AM4300 was used in Western Blotting to conclude that inhibitors of cellular PCNA block recruitment of key viral and cellular factors to viral DNA to inhibit viral DNA synthesis and coupled processes.</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36763621"> <div itemprop="name">Metformin regulates myoblast differentiation through an AMPK-dependent mechanism.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Maniscalco E,Abbadessa G,Giordano M,Grasso L,Borrione P,Racca S</div> <div itemprop="description">AM4300 was used in Western Blotting to provide solid evidence that most of the effects of Met on myoblasts and myotubes are mediated by AMPK.</div> <div itemprodp="datePublished">Tue Feb 14 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36786625"> <div itemprop="name">N<sup>6</sup>-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.</div> </a> <div itemprop="about">Microbiology spectrum</div> <div itemprop="author">Khan O,Tanuj GN,Choravada DR,Rajak KK,Chandra Sekar S,Lingaraju MC,Dhara SK,Gupta PK,Mishra BP,Dutt T,Gandham RK,Sajjanar B</div> <div itemprop="description">AM4300 was used in Western Blot to show that the m6A modification of RNA regulates PPRV replication.</div> <div itemprodp="datePublished">Tue Feb 14 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36604722"> <div itemprop="name">Cysteine dioxygenase and taurine are essential for embryo implantation by involving in E<sub>2</sub>-ERα and P<sub>4</sub>-PR signaling in mouse.</div> </a> <div itemprop="about">Journal of animal science and biotechnology</div> <div itemprop="author">Zhang D,Wang Z,Luo X,Guo H,Qiu G,Gong Y,Gao H,Cui S</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that taurine and CDO play prominent roles in uterine receptivity and embryo implantation by involving in E2-ERα and P4-PR signaling.</div> <div itemprodp="datePublished">Thu Jan 05 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36823395"> <div itemprop="name">Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia.</div> </a> <div itemprop="about">Leukemia</div> <div itemprop="author">Issa H,Swart LE,Rasouli M,Ashtiani M,Nakjang S,Jyotsana N,Schuschel K,Heuser M,Blair H,Heidenreich O</div> <div itemprop="description">AM4300 was used in Western Blotting to provide proof for the feasibility of targeting RUNX1/ETO in a pre-clinical setting and support the further development of siRNA-LNPs for the treatment of fusion gene-driven malignancies.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36102038"> <div itemprop="name">N-glycoproteomics reveals distinct glycosylation alterations in NGLY1-deficient patient-derived dermal fibroblasts.</div> </a> <div itemprop="about">Journal of inherited metabolic disease</div> <div itemprop="author">Budhraja R,Saraswat M,De Graef D,Ranatunga W,Ramarajan MG,Mousa J,Kozicz T,Pandey A,Morava E</div> <div itemprop="description">AM4300 was used in Western Blotting to highlight new molecular and system-level insights for understanding NGLY1-CDDG.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36596803"> <div itemprop="name">Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jobin ML,Siddig S,Koszegi Z,Lanoiselée Y,Khayenko V,Sungkaworn T,Werner C,Seier K,Misigaiski C,Mantovani G,Sauer M,Maric HM,Calebiro D</div> <div itemprop="description">AM4300 was used in Cell Culture to show that GABAB receptors are located together with filamin A in small nanodomains in hippocampal neurons.</div> <div itemprodp="datePublished">Tue Jan 03 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37173371"> <div itemprop="name">Polarity signaling balances epithelial contractility and mechanical resistance.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Rübsam M,Püllen R,Tellkamp F,Bianco A,Peskoller M,Bloch W,Green KJ,Merkel R,Hoffmann B,Wickström SA,Niessen CM</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that keratins sense the contractile stress state of stratified epithelia and balance increased contractility by mounting a protective response to maintain tissue integrity.</div> <div itemprodp="datePublished">Fri May 12 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36872299"> <div itemprop="name">Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">Solé M,Marazuela P,Castellote L,Bonaterra-Pastra A,Giménez-Llort L,Hernández-Guillamon M</div> <div itemprop="description">AM4300 was used in Western Blotting to show the potential therapeutic applicability of a safe and non-invasive treatment based on peripheral administration of hrApoA-I-M in Alzheimer's disease.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37345040"> <div itemprop="name">COL7A1 Expression Improves Prognosis Prediction for Patients with Clear Cell Renal Cell Carcinoma Atop of Stage.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Koca D,Séraudie I,Jardillier R,Cochet C,Filhol O,Guyon L</div> <div itemprop="description">AM4300 was used in Western Blotting to identify COL7A1 as a new prognosis marker that can stratify ccRCC patients.</div> <div itemprodp="datePublished">Wed May 10 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37407548"> <div itemprop="name">Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Irmady K,Hale CR,Qadri R,Fak J,Simelane S,Carroll T,Przedborski S,Darnell RB</div> <div itemprop="description">AM4300 was used in Western Blotting to identify molecular signatures in Parkinson's disease patients' brain and blood of potential pathophysiologic and prognostic importance.</div> <div itemprodp="datePublished">Wed Jul 05 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37784093"> <div itemprop="name">The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion.</div> </a> <div itemprop="about">Cell communication and signaling : CCS</div> <div itemprop="author">Gélabert C,Papoutsoglou P,Golán I,Ahlström E,Ameur A,Heldin CH,Caja L,Moustakas A</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the mechanism of action and biological role of Transforming growth factor β (TGFβ) signaling via Smad proteins in cancer.</div> <div itemprodp="datePublished">Mon Oct 02 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36723402"> <div itemprop="name">Substrate stiffness induces nuclear localization of myosin regulatory light chain to suppress apoptosis.</div> </a> <div itemprop="about">FEBS letters</div> <div itemprop="author">Onishi K,Ishihara S,Takahashi M,Sakai A,Enomoto A,Suzuki K,Haga H</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal a newly identified role of MRLC in mechanotransduction.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37064812"> <div itemprop="name">Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.</div> </a> <div itemprop="about">Autophagy reports</div> <div itemprop="author">Benyair R,Giridharan SSP,Rivero-Ríos P,Hasegawa J,Bristow E,Eskelinen EL,Shmueli MD,Fishbain-Yoskovitz V,Merbl Y,Sharkey LM,Paulson HL,Hanson PI,Patnaik S,Al-Ramahi I,Botas J,Marugan J,Weisman LS</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal that upregulation of traffic through an ESCRT-dependent MVB pathway may provide a therapeutic approach for neurodegenerative diseases.</div> <div itemprodp="datePublished">Wed Apr 19 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37064812"> <div itemprop="name">Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.</div> </a> <div itemprop="about">Autophagy reports</div> <div itemprop="author">Benyair R,Giridharan SSP,Rivero-Ríos P,Hasegawa J,Bristow E,Eskelinen EL,Shmueli MD,Fishbain-Yoskovitz V,Merbl Y,Sharkey LM,Paulson HL,Hanson PI,Patnaik S,Al-Ramahi I,Botas J,Marugan J,Weisman LS</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal that upregulation of traffic through an ESCRT-dependent MVB pathway may provide a therapeutic approach for neurodegenerative diseases.</div> <div itemprodp="datePublished">Wed Apr 19 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36583790"> <div itemprop="name">Intrinsic D614G and P681R/H mutations in SARS-CoV-2 VoCs Alpha, Delta, Omicron and viruses with D614G plus key signature mutations in spike protein alters fusogenicity and infectivity.</div> </a> <div itemprop="about">Medical microbiology and immunology</div> <div itemprop="author">Khatri R,Siddqui G,Sadhu S,Maithil V,Vishwakarma P,Lohiya B,Goswami A,Ahmed S,Awasthi A,Samal S</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal that D614G and P681R/H mutations in spike protein favor VoC replication in different host compartments, thus allowing a balance of mutation vs selection for better long-term adaptation.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37099199"> <div itemprop="name">HAMLET effect on cell death and mitochondrial respiration in colorectal cancer cell lines with KRAS/BRAF mutations.</div> </a> <div itemprop="about">Journal of cancer research and clinical oncology</div> <div itemprop="author">Žilinskas J,Stukas D,Jasukaitienė A,Šapauskienė J,Banienė R,Trumbeckaitė S,Švagždys S,Cicciu M,Dambrauskas Ž,Gulbinas A,Tamelis A</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate HAMLET effect on viability, death pathway and mitochondrial bioenergetics of CRC cells with different KRAS/BRAF mutational status in vitro.</div> <div itemprodp="datePublished">Fri Sep 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37443395"> <div itemprop="name">Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36.</div> </a> <div itemprop="about">Nature chemical biology</div> <div itemprop="author">O'Dea R,Kazi N,Hoffmann-Benito A,Zhao Z,Recknagel S,Wendrich K,Janning P,Gersch M</div> <div itemprop="description">AM4300 was used in Western Blotting to highlight how ubiquitin/Fubi specificity is achieved in a subset of human deubiquitinases and open the door to a systematic investigation of the Fubi system.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37122704"> <div itemprop="name">Mercury increases IL-1β and IL-18 secretion and intensifies coronary arteritis in an animal model of Kawasaki disease.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Alphonse MP,Duong TT,Tam S,Yeung RSM</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effect of mercury on inflammasome activation and its impact on the immunopathogenesis of Kawasaki disease (KD).</div> <div itemprodp="datePublished">Tue May 02 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37565427"> <div itemprop="name">The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Pannek A,Becker-Gotot J,Dower SK,Verhagen AM,Gleeson PA</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate FcRn-albumin trafficking in physiologically relevant endothelial cells.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35879364"> <div itemprop="name">Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.</div> </a> <div itemprop="about">Nature biotechnology</div> <div itemprop="author">Tolani B,Celli A,Yao Y,Tan YZ,Fetter R,Liem CR,de Smith AJ,Vasanthakumar T,Bisignano P,Cotton AD,Seiple IB,Rubinstein JL,Jost M,Weissman JS</div> <div itemprop="description">AM4300 was used in Flow cytometry/Cell sorting to establish proof-of-concept for targeting V-ATPase in cancers driven by specific KRAS mutations such as KRASG13D and G12V.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34862482"> <div itemprop="name">The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Valionyte E,Yang Y,Griffiths SA,Bone AT,Barrow ER,Sharma V,Lu B,Luo S</div> <div itemprop="description">AM4300 was used in Western Blot to show that p62-droplet formation is selectively blocked by inflammatory toxicity, which induces cleavage of p62 by caspase-6 at a novel cleavage site D256.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33375770"> <div itemprop="name">Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia.</div> </a> <div itemprop="about">Haematologica</div> <div itemprop="author">Damnernsawad A,Bottomly D,Kurtz SE,Eide CA,McWeeney SK,Tyner JW,Nechiporuk T</div> <div itemprop="description">AM4300 was used in Western Blot to show negative regulators of the MAPK and MTOR pathways LZTR1, NF1, TSC1/TSC2 are mediators of sorafenib resistance.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35819446"> <div itemprop="name">MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells.</div> </a> <div itemprop="about">Blood advances</div> <div itemprop="author">Matis S,Grazia Recchia A,Colombo M,Cardillo M,Fabbi M,Todoerti K,Bossio S,Fabris S,Cancila V,Massara R,Reverberi D,Emionite L,Cilli M,Cerruti G,Salvi S,Bet P,Pigozzi S,Fiocca R,Ibatici A,Angelucci E,Gentile M,Monti P,Menichini P,Fronza G,Torricelli F,Ciarrocchi A,Neri A,Fais F,Tripodo C,Morabito F,Ferrarini M,Cutrona G</div> <div itemprop="description">AM4300 was used in Flow cytometry/Cell sorting to indicate that IL-12β1 expression, a crucial checkpoint for the functioning of the IL-23/IL-23R complex loop, is under the control of miR-146b-5p, which may represent a potential target for therapy since it contributes to the CLL pathogenesis.</div> <div itemprodp="datePublished">Tue Oct 25 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35100311"> <div itemprop="name">Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Hsieh LT,Dos Santos SJ,Hall BS,Ogbechi J,Loglo AD,Salguero FJ,Ruf MT,Pluschke G,Simmonds RE</div> <div itemprop="description">AM4300 was used in Western Blot to explore the role of the vasculature in Buruli ulcer pathogenesis.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36100089"> <div itemprop="name">Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.</div> </a> <div itemprop="about">Journal of lipid research</div> <div itemprop="author">Östlund C,Hernandez-Ono A,Turk SJ,Dauer WT,Ginsberg HN,Worman HJ,Shin JY</div> <div itemprop="description">AM4300 was used in Western Blotting to show that LAP1-depleted hepatocytes represent an ideal mammalian system to investigate the biogenesis of nuclear LDs and their partitioning between the nucleus and cytoplasm in response to changes in nutritional state and cellular metabolism in vivo.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34666336"> <div itemprop="name">Prolactin Reduces Hippocampal Parvalbumin and GABAA Receptor Expression in Female Mice.</div> </a> <div itemprop="about">Neuroendocrinology</div> <div itemprop="author">Mellado S,Moreno-Ruiz B,Expósito S,Fernández M,Martín ED</div> <div itemprop="description">AM4300 was used in Western Blotting to study whether pituitary hormones are related to parvalbumin (PV) expression in the hippocampus demonstrating that increased prolactin (PRL) levels are associated with changes in key constituent elements of inhibitory circuits in the hippocampus.</div> <div itemprodp="datePublished">Thu Aug 04 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35035808"> <div itemprop="name">Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism.</div> </a> <div itemprop="about">Journal of healthcare engineering</div> <div itemprop="author">Liu J,Li C,Wang Q,Hu H,Li C,Qian J</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the influence of Toll-like receptor 2- (TLR2-) mediated inflammation on the occurrence and development of familial hypertension combined with hyperlipemia and its related mechanism.</div> <div itemprodp="datePublished">Thu Apr 21 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35154499"> <div itemprop="name">Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Vachon L,Smaani A,Tessier N,Jean G,Demers A,Milasan A,Ardo N,Jarry S,Villeneuve L,Alikashani A,Finherty V,Ruiz M,Sorci-Thomas MG,Mayer G,Martel C</div> <div itemprop="description">AM4300 was used in Western Blot to suggest that treatments that specifically palliate the down regulation of LDLR mRNA in lymphatic endothelial cells preserve the integrity of the lymphatic endothelium and sustain lymphatic function, a prerequisite player in atherosclerosis.</div> <div itemprodp="datePublished">Thu Apr 21 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35133274"> <div itemprop="name">Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Pereira C,Arroyo-Martinez GA,Guo MZ,Downey MS,Kelly ER,Grive KJ,Mahadevaiah SK,Sims JR,Faca VM,Tsai C,Schiltz CJ,Wit N,Jacobs H,Clark NL,Freire R,Turner J,Lyndaker AM,Brieno-Enriquez MA,Cohen PE,Smolka MB,Weiss RS</div> <div itemprop="description">AM4300 was used in Immunohistochemistry, Western Blot to establish critical roles for both canonical and alternative 9-1-1 complexes in meiotic ATR activation and successful prophase I completion.</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35133274"> <div itemprop="name">Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Pereira C,Arroyo-Martinez GA,Guo MZ,Downey MS,Kelly ER,Grive KJ,Mahadevaiah SK,Sims JR,Faca VM,Tsai C,Schiltz CJ,Wit N,Jacobs H,Clark NL,Freire R,Turner J,Lyndaker AM,Brieno-Enriquez MA,Cohen PE,Smolka MB,Weiss RS</div> <div itemprop="description">AM4300 was used in Immunohistochemistry, Western Blot to establish critical roles for both canonical and alternative 9-1-1 complexes in meiotic ATR activation and successful prophase I completion.</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35060363"> <div itemprop="name">Histone deacetylase HDAC2 regulates microRNA-125a expression in neuroblastoma.</div> </a> <div itemprop="about">Brain and behavior</div> <div itemprop="author">Liu D,Tang X,Huang Z,Wen J,Zhou Y</div> <div itemprop="description">AM4300 was used in Western Blotting to ascertain whether miR-125a exerts antitumor effects in NB.</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36444295"> <div itemprop="name">Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca<sup>2+</sup> channels and activation of store-operated Ca<sup>2+</sup> entry.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Terry LE,Arige V,Neumann J,Wahl AM,Knebel TR,Chaffer JW,Malik S,Liston A,Humblet-Baron S,Bultynck G,Yule DI</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that a common feature of these mutations is decreased IP3R3 function and that these mutations exhibit a novel phenotype manifested as a constitutively open channel, which inappropriately gates SOCE in the absence of stimulation.</div> <div itemprodp="datePublished">Thu Dec 22 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36613756"> <div itemprop="name">Inactivation of PTEN and ZFHX3 in Mammary Epithelial Cells Alters Patterns of Collective Cell Migration.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Dayoub A,Fokin AI,Lomakina ME,James J,Plays M,Jacquin T,Novikov NM,Vorobyov RS,Schegoleva AA,Rysenkova KD,Gaboriaud J,Leonov SV,Denisov EV,Gautreau AM,Alexandrova AY</div> <div itemprop="description">AM4300 was used in Western Blotting to generate single and combined PTEN and ZFHX3 knock-outs (KOs) in the immortalized mammary epithelial cell line MCF10A to study the role of these genes and their potential synergy in migration regulation.</div> <div itemprodp="datePublished">Sat Dec 24 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34553752"> <div itemprop="name">MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Tidyman WE,Goodwin AF,Maeda Y,Klein OD,Rauen KA</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the mechanisms underlying hypotonia in Costello syndrome.</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35721485"> <div itemprop="name">m<sup>6</sup>A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Qu W,Li Q,Wang M,Zhao X,Wu J,Liu D,Hong S,Yang Y,Shu Q,Li X</div> <div itemprop="description">AM4300 was used in Western Blotting to study the environment exposure modification of neurogenesis.</div> <div itemprodp="datePublished">Sat Jul 16 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35203105"> <div itemprop="name">NOX4 regulates TGFβ-induced proliferation and self-renewal in glioblastoma stem cells.</div> </a> <div itemprop="about">Molecular oncology</div> <div itemprop="author">García-Gómez P,Golán I,S Dadras M,Mezheyeuski A,Bellomo C,Tzavlaki K,Morén A,Carreras-Puigvert J,Caja L</div> <div itemprop="description">AM4300 was used in Western Blotting to establish NOX4 as a key mediator of GSC biology.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35013311"> <div itemprop="name">Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Therizols G,Bash-Imam Z,Panthu B,Machon C,Vincent A,Ripoll J,Nait-Slimane S,Chalabi-Dchar M,Gaucherot A,Garcia M,Laforêts F,Marcel V,Boubaker-Vitre J,Monet MA,Bouclier C,Vanbelle C,Souahlia G,Berthel E,Albaret MA,Mertani HC,Prudhomme M,Bertrand M,David A,Saurin JC,Bouvet P,Rivals E,Ohlmann T,Guitton J,Dalla Venezia N,Pannequin J,Catez F,Diaz JJ</div> <div itemprop="description">AM4300 was used in Western Blot to show that 5-fluorouracil treatment leads to the production of fluorinated ribosomes exhibiting altered translational activities.</div> <div itemprodp="datePublished">Mon Jan 10 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35789155"> <div itemprop="name">Ets1 mediates sorafenib resistance by regulating mitochondrial ROS pathway in hepatocellular carcinoma.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Vishnoi K,Ke R,Viswakarma N,Srivastava P,Kumar S,Das S,Singh SK,Principe DR,Rana A,Rana B</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate the activation of a novel Ets-1-GPX2 signaling axis in soraR cells, targeting which might successfully antagonize resistance and increase efficacy.</div> <div itemprodp="datePublished">Mon Jul 04 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35438536"> <div itemprop="name">The HIV-1 Viral Protease Is Activated during Assembly and Budding Prior to Particle Release.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Tabler CO,Wegman SJ,Chen J,Shroff H,Alhusaini N,Tilton JC</div> <div itemprop="description">AM4300 was used in Western Blotting to find that protease is fully activated before virus is released from the cell membrane, which is hours earlier than recent estimates.</div> <div itemprodp="datePublished">Wed May 11 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36231009"> <div itemprop="name">Nestin Modulates Airway Smooth Muscle Cell Migration by Affecting Spatial Rearrangement of Vimentin Network and Focal Adhesion Assembly.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Wang R,Khan S,Liao G,Wu Y,Tang DD</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that nestin promotes smooth muscle cell migration.</div> <div itemprodp="datePublished">Thu Sep 29 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35114252"> <div itemprop="name">Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels.</div> </a> <div itemprop="about">Journal of molecular and cellular cardiology</div> <div itemprop="author">O' Brien S,Holmes AP,Johnson DM,Kabir SN,O' Shea C,O' Reilly M,Avezzu A,Reyat JS,Hall AW,Apicella C,Ellinor PT,Niederer S,Tucker NR,Fabritz L,Kirchhof P,Pavlovic D</div> <div itemprop="description">AM4300 was used in Western Blotting to highlight differences in biophysical properties of sodium channels in left atria and ventricles and their response to flecainide.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36223101"> <div itemprop="name">Hypoxia-Inducible Factor-1α in Rods Is Neuroprotective Following Retinal Detachment.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Ross BX,Jia L,Kong D,Wang T,Yao J,Hager HM,Abcouwer SF,Zacks DN</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the necessity of HIF-1α on photoreceptors cell survival after retinal detachment.</div> <div itemprodp="datePublished">Mon Oct 03 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34982967"> <div itemprop="name">High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Tada T,Zhou H,Dcosta BM,Samanovic MI,Cornelius A,Herati RS,Mulligan MJ,Landau NR</div> <div itemprop="description">AM4300 was used in Western Blot to study the infectivity of SARS-CoV-2 variants Mu, C.1.2, and Delta+N501S spike proteins and determine their susceptibility to neutralization by convalescent and vaccine-elicited antibodies, both in previously infected and uninfected individuals.</div> <div itemprodp="datePublished">Tue Jan 11 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35081348"> <div itemprop="name">MYC amplifies gene expression through global changes in transcription factor dynamics.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Patange S,Ball DA,Wan Y,Karpova TS,Girvan M,Levens D,Larson DR</div> <div itemprop="description">AM4300 was used in Western Blotting to propose that the mechanism by which MYC exerts global effects on the active period of genes is by altering the binding dynamics of transcription factors involved in RNA polymerase II complex assembly and productive elongation.</div> <div itemprodp="datePublished">Tue Jan 25 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36516126"> <div itemprop="name">Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Rei N,Valente CA,Vaz SH,Farinha-Ferreira M,Ribeiro JA,Sebastião AM</div> <div itemprop="description">AM4300 was used in Western Blotting to study an early dysfunction of the adenosinergic system in ALS and suggest the possibility that the negative influence of caffeine previously reported in ALS animal models results from interference with BDNF rather than with the VEGF signaling molecules.</div> <div itemprodp="datePublished">Fri Dec 16 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36356583"> <div itemprop="name">Transcription factor antagonism regulates heterogeneity in embryonic stem cell states.</div> </a> <div itemprop="about">Molecular cell</div> <div itemprop="author">Hu S,Metcalf E,Mahat DB,Chan L,Sohal N,Chakraborty M,Hamilton M,Singh A,Singh A,Lees JA,Sharp PA,Garg S</div> <div itemprop="description">AM4300 was used in Western Blotting to show antagonism between factors at enhancers results in gene expression heterogeneity and formation of cell states, with implications for the generation of diverse cell types during development.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35643234"> <div itemprop="name">Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Hou Y,Sun X,Gheinani PT,Guan X,Sharma S,Zhou Y,Jin C,Yang Z,Naren AP,Yin J,Denning TL,Gewirtz AT,Liu Y,Xie Z,Li C</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the role and underlying mechanism of epithelial SMYD5 in IBD pathogenesis and progression.</div> <div itemprodp="datePublished">Mon Jul 25 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36263624"> <div itemprop="name">Short-term and bystander effects of radiation on murine submandibular glands.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Uchida H,Ingalls MH,Maruyama EO,Johnston CJ,Hernady E,Faustoferri RC,Ovitt CE</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the mechanisms of cellular damage induced by radiation treatment.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35455963"> <div itemprop="name">NAD+ Modulates the Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells via Akt Signaling Pathway.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Huang X,Guo H,Cheng X,Zhang J,Qu W,Ding Q,Sun Q,Shu Q,Li X</div> <div itemprop="description">AM4300 was used in Western Blotting to show that nicotinamide adenine dinucleotide hydrate (NAD+) exposure leads to the reduced proliferation and neuronal differentiation of adult neural stem/progenitor cells (aNSPCs) and induces the apoptosis of aNSPCs.</div> <div itemprodp="datePublished">Sat Apr 09 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36377048"> <div itemprop="name">Involvement of Ca<sub>V</sub> 2.2 channels and α<sub>2</sub> δ-1 in homeostatic synaptic plasticity in cultured hippocampal neurons.</div> </a> <div itemprop="about">The Journal of physiology</div> <div itemprop="author">Pilch KS,Ramgoolam KH,Dolphin AC</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal a key role for CaV 2.2 channels and novel roles for α2 δ-1 during synaptic plastic adaptation.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34990403"> <div itemprop="name">The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Blackwell DJ,Faggioni M,Wleklinski MJ,Gomez-Hurtado N,Venkataraman R,Gibbs CE,Baudenbacher FJ,Gong S,Fishman GI,Boyle PM,Pfeifer K,Knollmann BC</div> <div itemprop="description">AM4300 was used in Western Blot to conclude that ectopic beats in CPVT are likely generated at the Purkinje-myocardial junction via a heretofore unrecognized tissue mechanism, whereby DADs in the ventricular myocardium trigger full action potentials in adjacent Purkinje cells.</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35901345"> <div itemprop="name">Phyllanthus taxodiifolius Beille Disrupted N-cadherin, Vimentin, Paxillin and Actin Stress Fibers in Glioblastoma.</div> </a> <div itemprop="about">Asian Pacific journal of cancer prevention : APJCP</div> <div itemprop="author">Sunrat C,Kwanthongdee J,Uppakara K,Chabang N,Munyoo B,Tuchinda P,Saengsawang W</div> <div itemprop="description">AM4300 was used in Western Blotting to explore the effects of Phyllanthus taxodiifolius Beille extract on molecules known to be hallmarks of aggressive glioblastoma including N-cadherin and vimentin, mesenchymal markers, and paxillin.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35893676"> <div itemprop="name">TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.</div> </a> <div itemprop="about">Viruses</div> <div itemprop="author">Luptak J,Mallery DL,Jahun AS,Albecka A,Clift D,Ather O,Slodkowicz G,Goodfellow I,James LC</div> <div itemprop="description">AM4300 was used in Western Blotting to show that TRIM7's extreme substrate promiscuity is due to a highly unusual binding mechanism.</div> <div itemprodp="datePublished">Sat Jul 23 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36484008"> <div itemprop="name">Microarray Analysis Reveals Overexpression of both Integral Membrane and Cytosolic Tight Junction Genes in Endometrial Cancer Cell Lines.</div> </a> <div itemprop="about">Journal of Cancer</div> <div itemprop="author">Cuevas ME,Winters CP,Todd MC</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that the structural disruption of tight junction coupled with the downstream deregulation of signaling pathways involved in cellular proliferation and migration may contribute to the development of endometrial cancer.</div> <div itemprodp="datePublished">Sat Dec 10 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35847979"> <div itemprop="name">CK2β Is a Gatekeeper of Focal Adhesions Regulating Cell Spreading.</div> </a> <div itemprop="about">Frontiers in molecular biosciences</div> <div itemprop="author">Filhol O,Hesse AM,Bouin AP,Albigès-Rizo C,Jeanneret F,Battail C,Pflieger D,Cochet C</div> <div itemprop="description">AM4300 was used in Western Blotting to show that decreased expression of CK2β in MCF10A mammary epithelial cells triggers the phosphorylation of a number of proteins on tyrosine residues and promotes the striking activation of the FAK1-Src-PAX1 signaling pathway.</div> <div itemprodp="datePublished">Tue Jul 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35005542"> <div itemprop="name">GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Selyutina A,Hu P,Miller S,Simons LM,Yu HJ,Hultquist JF,Lee K,KewalRamani VN,Diaz-Griffero F</div> <div itemprop="description">AM4300 was used in Western Blot to show that GS-CA1 binds to the HIV-1 core, changes its conformation, stabilizes the core, and thereby prevents viral uncoating and infection.</div> <div itemprodp="datePublished">Fri Jan 21 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36083588"> <div itemprop="name">Loss of Fas Receptor Function Preserves Photoreceptor Structure and Function in Two Mouse Models of Inherited Retinal Degeneration.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Yao J,Wang T,Jia L,Qiu Y,Zacks DN</div> <div itemprop="description">AM4300 was used in Immunohistochemistry (Paraffin) to conclude that reducing Fas activity might represent a potential mutation-independent therapeutic approach to preserve retinal structure and function in patients with inherited retinal degeneration (IRD).</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35945910"> <div itemprop="name">Mammaglobin 1 mediates progression of trastuzumab-resistant breast cancer cells through regulation of cyclins and NF-κB.</div> </a> <div itemprop="about">FEBS open bio</div> <div itemprop="author">Kusumastuti R,Kumagai Y,Ishihara S,Enomoto A,Murakami T,Yasuda M,Haga H</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that MGB1 expression is increased in breast cancer cells that have gained resistance to trastuzumab, and suggest that MGB1 promotes aggressiveness through cyclin and NF-κB regulation.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36306014"> <div itemprop="name">Structure and function of the N-terminal extension of the formin INF2.</div> </a> <div itemprop="about">Cellular and molecular life sciences : CMLS</div> <div itemprop="author">Labat-de-Hoz L,Comas L,Rubio-Ramos A,Casares-Arias J,Fernández-Martín L,Pantoja-Uceda D,Martín MT,Kremer L,Jiménez MA,Correas I,Alonso MA</div> <div itemprop="description">AM4300 was used in Immunocytochemistry, Western Blot to show that the N-terminal extension of INF2 is organized into two α-helices, the first of which is necessary to maintain the perinuclear F-actin ring and normal cytosolic F-actin content.</div> <div itemprodp="datePublished">Fri Oct 28 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36306014"> <div itemprop="name">Structure and function of the N-terminal extension of the formin INF2.</div> </a> <div itemprop="about">Cellular and molecular life sciences : CMLS</div> <div itemprop="author">Labat-de-Hoz L,Comas L,Rubio-Ramos A,Casares-Arias J,Fernández-Martín L,Pantoja-Uceda D,Martín MT,Kremer L,Jiménez MA,Correas I,Alonso MA</div> <div itemprop="description">AM4300 was used in Immunocytochemistry, Western Blot to show that the N-terminal extension of INF2 is organized into two α-helices, the first of which is necessary to maintain the perinuclear F-actin ring and normal cytosolic F-actin content.</div> <div itemprodp="datePublished">Fri Oct 28 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35119364"> <div itemprop="name">Induction of osteogenesis by bone-targeted Notch activation.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Xu C,Dinh VV,Kruse K,Jeong HW,Watson EC,Adams S,Berkenfeld F,Stehling M,Rasouli SJ,Fan R,Chen R,Bedzhov I,Chen Q,Kato K,Pitulescu ME,Adams RH</div> <div itemprop="description">AM4300 was used in Immunohistochemistry to propose that activation of Notch signaling by bone-targeted fusion proteins might be therapeutically useful and can avoid detrimental effects in Notch-dependent processes in other organs.</div> <div itemprodp="datePublished">Fri Feb 04 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35139382"> <div itemprop="name">PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Sun L,Wang Y,Wang X,Navarro-Corcuera A,Ilyas S,Jalan-Sakrikar N,Gan C,Tu X,Shi Y,Tu K,Liu Q,Lou Z,Dong H,Sharpe AH,Shah VH,Kang N</div> <div itemprop="description">AM4300 was used in Functional Assay to conclude that myofibroblast PD-L1 can modulate the tumor microenvironment and tumor growth by a mechanism independent of immune suppression.</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35840569"> <div itemprop="name">Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Darp R,Vittoria MA,Ganem NJ,Ceol CJ</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate if BRAFV600E, the most common mutation in melanomas, can induce whole-genome doubling via cytokinesis failure in vitro and in a zebrafish melanoma model.</div> <div itemprodp="datePublished">Fri Jul 15 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35858839"> <div itemprop="name">Deep learning for de-convolution of Smad2 versus Smad3 binding sites.</div> </a> <div itemprop="about">BMC genomics</div> <div itemprop="author">Ng JWK,Ong EHQ,Tucker-Kellogg L,Tucker-Kellogg G</div> <div itemprop="description">AM4300 was used in Western Blotting to identify Smad-specific binding sites in a cancer cell line.</div> <div itemprodp="datePublished">Wed Jul 20 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35034279"> <div itemprop="name">Cardiac troponin T and autoimmunity in skeletal muscle aging.</div> </a> <div itemprop="about">GeroScience</div> <div itemprop="author">Zhang T,Feng X,Dong J,Xu Z,Feng B,Haas KM,Cawthon PM,Beavers KM,Nicklas B,Kritchevsky S</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest a novel cTnT-mediated autoimmune response may be an indicator of sarcopenia.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35788194"> <div itemprop="name">A bioinformatic analysis study of m<sup>7</sup>G regulator-mediated methylation modification patterns and tumor microenvironment infiltration in glioblastoma.</div> </a> <div itemprop="about">BMC cancer</div> <div itemprop="author">Wu X,Li C,Wang Z,Zhang Y,Liu S,Chen S,Chen S,Liu W,Liu X</div> <div itemprop="description">AM4300 was used in Western Blotting to show establishment of a prognostic signature and the extended analysis of the tumor microenvironment, immune correlation, and tumor mutation burden further suggest the important role of m7G in the development and development of this disease.</div> <div itemprodp="datePublished">Mon Jul 04 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34693597"> <div itemprop="name">High expression of NFX1-123 in HPV positive head and neck squamous cell carcinomas.</div> </a> <div itemprop="about">Head & neck</div> <div itemprop="author">Chintala S,Quist KM,Gonzalez-DeWhitt PA,Katzenellenbogen RA</div> <div itemprop="description">AM4300 was used in Western Blotting to show that NFX1-123 and a subset of its known targets were increased in HPV+ HNSCCs.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35736244"> <div itemprop="name">A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex.</div> </a> <div itemprop="about">Nucleic acids research</div> <div itemprop="author">Fasimoye RY,Spencer REB,Soto-Martin E,Eijlers P,Elmassoudi H,Brivio S,Mangana C,Sabele V,Rechtorikova R,Wenzel M,Connolly B,Pettitt J,Müller B</div> <div itemprop="description">AM4300 was used in Western Blotting to identify a novel, nematode-specific protein required for SL1 trans-splicing, which we designate SNA-3.</div> <div itemprodp="datePublished">Fri Jul 22 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36477472"> <div itemprop="name">Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Rodrigues-Junior DM,Raminelli C,Hassanie H,Trossini GHG,Perecim GP,Caja L,Moustakas A,Vettore AL</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal a potential therapeutic application of A5 and C1 as cytotoxic agents against GBM cells and predicted molecular networks that can be further exploited to characterize the pharmacological effects of these isoquinoline-containing substances.</div> <div itemprodp="datePublished">Wed Dec 07 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36162056"> <div itemprop="name">Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity.</div> </a> <div itemprop="about">Diabetes</div> <div itemprop="author">Ramms B,Pollow DP,Zhu H,Nora C,Harrington AR,Omar I,Gordts PLSM,Wortham M,Sander M</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that targeting LSD1 could be a strategy for treatment of obesity and its associated complications including type 2 diabetes and NAFLD.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35210456"> <div itemprop="name">Sex-specific differences in KCC2 localisation and inhibitory synaptic transmission in the rat hippocampus.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Wolf DC,Sanon NT,Cunha AOS,Chen JS,Shaker T,Elhassan AR,do Nascimento ASF,Di Cristo G,Weil AG</div> <div itemprop="description">AM4300 was used in Western Blotting to show that perinatal testosterone levels modulate GABAergic circuit function, suggesting a critical role of perinatal sex hormones in regulating network excitability in the adult hippocampus.</div> <div itemprodp="datePublished">Thu Feb 24 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35216222"> <div itemprop="name">miRNome Profiling and Functional Analysis Reveal Involvement of hsa-miR-1246 in Colon Adenoma-Carcinoma Transition by Targeting <i>AXIN2</i> and <i>CFTR</i>.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Lukosevicius R,Juzenas S,Salteniene V,Kulokiene U,Arstikyte J,Hemmrich-Stanisak G,Franke A,Link A,Ruzgys P,Satkauskas S,Pauzas H,Latkauskas T,Kiudelis G,Balaguer F,Kupcinskas J,Skieceviciene J</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal involvement of hsa-miR-1246 in early colorectal cancer development and regulation of tumor suppressors AXIN2 and CFTR.</div> <div itemprodp="datePublished">Mon Feb 14 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36150501"> <div itemprop="name">Serine 13 of the human cytomegalovirus viral cyclin-dependent kinase UL97 is required for regulatory protein 14-3-3 binding and UL97 stability.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Iwahori S,Umaña AC,Kalejta RF,Murata T</div> <div itemprop="description">AM4300 was used in Western Blotting to conclude that 14-3-3 proteins interact with and stabilize UL97 during HCMV infection.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35427166"> <div itemprop="name">Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Swiatlowska P,Sit B,Feng Z,Marhuenda E,Xanthis I,Zingaro S,Ward M,Zhou X,Xiao Q,Shanahan C,Jones GE,Yu CH,Iskratsch T</div> <div itemprop="description">AM4300 was used in Western Blotting to show how different pathological mechanical signals combined but through distinct pathways accelerate a phenotypic switch that will ultimately contribute to atherosclerotic disease progression.</div> <div itemprodp="datePublished">Fri Apr 15 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35427166"> <div itemprop="name">Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Swiatlowska P,Sit B,Feng Z,Marhuenda E,Xanthis I,Zingaro S,Ward M,Zhou X,Xiao Q,Shanahan C,Jones GE,Yu CH,Iskratsch T</div> <div itemprop="description">AM4300 was used in Western Blotting to show how different pathological mechanical signals combined but through distinct pathways accelerate a phenotypic switch that will ultimately contribute to atherosclerotic disease progression.</div> <div itemprodp="datePublished">Fri Apr 15 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35879337"> <div itemprop="name">Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Campeau MA,Leask RL</div> <div itemprop="description">AM4300 was used in Immunocytochemistry, Western Blot, Immunoprecipitation to demonstrate the potential of EMPA to resolve the inflammatory response of ECs caused by sustained GCX disruption while altering UPR signaling under endoplasmic reticulum stress.</div> <div itemprodp="datePublished">Mon Jul 25 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35681501"> <div itemprop="name">The Actin Cytoskeleton Responds to Inflammatory Cues and Alters Macrophage Activation.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Ronzier E,Laurenson AJ,Manickam R,Liu S,Saintilma IM,Schrock DC,Hammer JA,Rotty JD</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that interplay between myosin II and Arp2/3 influences macrophage activity, and potentially impacts adaptive-innate immune coordination.</div> <div itemprodp="datePublished">Tue May 31 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35360237"> <div itemprop="name">Aldosterone-Induced Sarco/Endoplasmic Reticulum Ca<sup>2+</sup> Pump Upregulation Counterbalances Ca<sub>v</sub>1.2-Mediated Ca<sup>2+</sup> Influx in Mesenteric Arteries.</div> </a> <div itemprop="about">Frontiers in physiology</div> <div itemprop="author">Salazar-Enciso R,Guerrero-Hernández A,Gómez AM,Benitah JP,Rueda A</div> <div itemprop="description">AM4300 was used in Western Blotting to provide novel evidence for short-term ALDO-induced upregulation of the functional unit comprising Cav1.2, SERCA2 pump, RyRs, and BKCa channels; in which the SERCA pump buffers ALDO-induced upregulation of Ca2+ entry at the superficial SR-PM nanodomain of MASMCs, preventing ALDO-triggered depolarization-induced vasoconstriction and enhancing vasodilation.</div> <div itemprodp="datePublished">Sat Apr 02 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36398858"> <div itemprop="name">LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Wu Z,Berlemann LA,Bader V,Sehr DA,Dawin E,Covallero A,Meschede J,Angersbach L,Showkat C,Michaelis JB,Münch C,Rieger B,Namgaladze D,Herrera MG,Fiesel FC,Springer W,Mendes M,Stepien J,Barkovits K,Marcus K,Sickmann A,Dittmar G,Busch KB,Riedel D,Brini M,Tatzelt J,Cali T,Winklhofer KF</div> <div itemprop="description">AM4300 was used in Western Blot to reveal a role for mitochondria in amplifying TNF-mediated NF-κB activation, both serving as a signaling platform, as well as a transport mode for activated NF-κB to the nuclear.</div> <div itemprodp="datePublished">Thu Dec 15 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35783863"> <div itemprop="name">Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor.</div> </a> <div itemprop="about">Frontiers in cardiovascular medicine</div> <div itemprop="author">Bisserier M,Brojakowska A,Saffran N,Rai AK,Lee B,Coleman M,Sebastian A,Evans A,Mills PJ,Addya S,Arakelyan A,Garikipati VNS,Hadri L,Goukassian DA</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that astronaut-derived small extracellular vesicles may epigenetically repress the expression of the vitamin D receptor (VDR) in human adult cardiomyocytes by promoting the activation of the PRC2 complex and H3K27me3 levels.</div> <div itemprodp="datePublished">Sat Aug 13 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36344503"> <div itemprop="name">Specialist multidisciplinary input maximises rare disease diagnoses from whole genome sequencing.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Macken WL,Falabella M,McKittrick C,Pizzamiglio C,Ellmers R,Eggleton K,Woodward CE,Patel Y,Labrum R,Phadke R,Reilly MM,DeVile C,Sarkozy A,Footitt E,Davison J,Rahman S,Houlden H,Bugiardini E,Quinlivan R,Hanna MG,Vandrovcova J,Pitceathly RDS</div> <div itemprop="description">AM4300 was used in Western Blotting to show that specialist multidisciplinary analysis of whole genome sequencing (WGS), following an initial 'no primary findings' (NPF) report, improves diagnostic rates and alters management.</div> <div itemprodp="datePublished">Mon Nov 07 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36333379"> <div itemprop="name">Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Moore TM,Cheng L,Wolf DM,Ngo J,Segawa M,Zhu X,Strumwasser AR,Cao Y,Clifford BL,Ma A,Scumpia P,Shirihai OS,Vallim TQA,Laakso M,Lusis AJ,Hevener AL,Zhou Z</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that Parkin regulates mitochondrial homeostasis by balancing mitophagy and Pgc1α-mediated mitochondrial biogenesis in white adipocytes, suggesting a potential therapeutic target in adipocytes to combat obesity and obesity-associated disorders.</div> <div itemprodp="datePublished">Fri Nov 04 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35628363"> <div itemprop="name">β-Elemene Attenuates Renal Fibrosis in the Unilateral Ureteral Obstruction Model by Inhibition of STAT3 and Smad3 Signaling via Suppressing MyD88 Expression.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Sun W,Kim DH,Byon CH,Choi HI,Park JS,Bae EH,Ma SK,Kim SW</div> <div itemprop="description">AM4300 was used in Western Blotting to elucidate the anti-interstitial fibrosis effect of β-elemene, which provides a new direction for future research and development of drugs related to chronic kidney disease.</div> <div itemprodp="datePublished">Mon May 16 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36123354"> <div itemprop="name">A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Genuth NR,Shi Z,Kunimoto K,Hung V,Xu AF,Kerr CH,Tiu GC,Oses-Prieto JA,Salomon-Shulman REA,Axelrod JD,Burlingame AL,Loh KM,Barna M</div> <div itemprop="description">AM4300 was used in Western Blot to reveal unexpected ribosome composition modularity that controls differentiation and development through the specialized translation of key signaling networks.</div> <div itemprodp="datePublished">Mon Sep 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36195608"> <div itemprop="name">Proteotoxic stress-induced apoptosis in cancer cells: understanding the susceptibility and enhancing the potency.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Iuliano L,Dalla E,Picco R,Mallavarapu S,Minisini M,Malavasi E,Brancolini C</div> <div itemprop="description">AM4300 was used in Western Blotting to determine proteotoxic stress response abilities of leiomyosarcoma.</div> <div itemprodp="datePublished">Tue Oct 04 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35439436"> <div itemprop="name">High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Frazier K,Kambal A,Zale EA,Pierre JF,Hubert N,Miyoshi S,Miyoshi J,Ringus DL,Harris D,Yang K,Carroll K,Hermanson JB,Chlystek JS,Overmyer KA,Cham CM,Musch MW,Coon JJ,Chang EB,Leone VA</div> <div itemprop="description">AM4300 was used in Western Blotting to report the host C-type lectin antimicrobial peptide Reg3γ works with key ileal microbes to orchestrate these interactions in a bidirectional manner and does not correlate with the intestinal core circadian clock.</div> <div itemprodp="datePublished">Wed Jun 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33857425"> <div itemprop="name">Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM</div> <div itemprop="description">AM4300 was used in Western Blot to conclude that epigenetic immunoediting may drive an acquired immune evasion program in the most aggressive mesenchymal GBM subtype by reshaping the tumor immune microenvironment.</div> <div itemprodp="datePublished">Thu Apr 29 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33214166"> <div itemprop="name">Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.</div> </a> <div itemprop="about">Gut</div> <div itemprop="author">Takeuchi M,Vidigal PT,Guerra MT,Hundt MA,Robert ME,Olave-Martinez M,Aoki S,Khamphaya T,Kersten R,Kruglov E,de la Rosa Rodriguez R,Banales JM,Nathanson MH,Weerachayaphorn J</div> <div itemprop="description">AM4300 was used in Western Blotting to examine whether bile ducts participate in the pathogenesis of Alcoholic hepatitis.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33406405"> <div itemprop="name">Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.</div> </a> <div itemprop="about">Cell metabolism</div> <div itemprop="author">Li Z,Liu H,He J,Wang Z,Yin Z,You G,Wang Z,Davis RE,Lin P,Bergsagel PL,Manasanch EE,Wong STC,Esnaola NF,Chang JC,Orlowski RZ,Yi Q,Yang J</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate a key impact for obesity-induced acetyl-CoA synthetase 2 on the progression of myeloma.</div> <div itemprodp="datePublished">Tue Jan 05 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33820972"> <div itemprop="name">Liquid-like protein interactions catalyse assembly of endocytic vesicles.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Day KJ,Kago G,Wang L,Richter JB,Hayden CC,Lafer EM,Stachowiak JC</div> <div itemprop="description">AM4300 was used in Western Blot to show that Eps15 and Fcho1/2 rely on weak, liquid-like interactions to catalyse endocytosis.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33945794"> <div itemprop="name">Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Wosczyna MN,Perez Carbajal EE,Wagner MW,Paredes S,Konishi CT,Liu L,Wang TT,Walsh RA,Gan Q,Morrissey CS,Rando TA</div> <div itemprop="description">AM4300 was used in Western Blotting to provide insight into the underlying molecular mechanisms of fibroadipogenic progenitors fate determination and formation of harmful fatty deposits in skeletal muscle.</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33956074"> <div itemprop="name">GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Drzewiecki K,Choi J,Brancale J,Leney-Greene MA,Sari S,Dalgiç B,Ünlüsoy Aksu A,Evirgen Şahin G,Ozen A,Baris S,Karakoc-Aydiner E,Jain D,Kleiner D,Schmalz M,Radhakrishnan K,Zhang J,Hoebe K,Su HC,Pereira JP,Lenardo MJ,Lifton RP,Vilarinho S</div> <div itemprop="description">AM4300 was used in Western Blot to identify genetic causes of portal hypertension that occur in the absence of primary disease of the liver parenchyma.</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33034061"> <div itemprop="name">Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Papathanasiou M,Tsiftsoglou SA,Polyzos AP,Papadopoulou D,Valakos D,Klagkou E,Karagianni P,Pliatska M,Talianidis I,Agelopoulos M,Thanos D</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the early transcriptional events of cellular reprogramming triggered by the co-expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) in mouse embryonic fibroblasts (MEFs) and mouse hepatocytes (mHeps).</div> <div itemprodp="datePublished">Mon Jan 04 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33590792"> <div itemprop="name">Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Robichaud S,Fairman G,Vijithakumar V,Mak E,Cook DP,Pelletier AR,Huard S,Vanderhyden BC,Figeys D,Lavallée-Adam M,Baetz K,Ouimet M</div> <div itemprop="description">AM4300 was used in Western Blotting to identify several LD-associated proteins of the lipophagy machinery, a finding with important biological and therapeutic implications.</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34782467"> <div itemprop="name">The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Colombo E,Horta G,Roesler MK,Ihbe N,Chhabra S,Radyushkin K,Di Liberto G,Kreutzfeldt M,Schumann S,von Engelhardt J,Merkler D,Behl C,Mittmann T,Clement AM,Waisman A,Schmeisser MJ</div> <div itemprop="description">AM4300 was used in Western Blotting to better understand if CYLD plays a role in brain and synapse homeostasis.</div> <div itemprodp="datePublished">Tue Nov 23 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34417304"> <div itemprop="name">A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Kaugars K,Dardick J,de Oliveira AP,Weiss KA,Lukose R,Kim J,Leung L,Rajagopalan S,Wolin S,Akabas L,Knipe DM,Bajic G,Jacobs WR</div> <div itemprop="description">AM4300 was used in Western Blot to develop antibody-dependent cellular cytotoxicity-eliciting influenza vaccine.</div> <div itemprodp="datePublished">Tue Aug 24 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34530051"> <div itemprop="name">P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation.</div> </a> <div itemprop="about">Journal of controlled release : official journal of the Controlled Release Society</div> <div itemprop="author">Mocanu CA,Fuior EV,Voicu G,Rebleanu D,Safciuc F,Deleanu M,Fenyo IM,Escriou V,Manduteanu I,Simionescu M,Calin M</div> <div itemprop="description">AM4300 was used in Western Blot to develop targeted lipoplexes carrying the receptor for advanced glycation end products (RAGE)-short hairpin RNA to down-regulate endothelial RAGE expression as a therapeutic strategy for atherosclerosis.</div> <div itemprodp="datePublished">Sun Oct 10 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33075426"> <div itemprop="name">The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells.</div> </a> <div itemprop="about">Cancer letters</div> <div itemprop="author">Catalano R,Giardino E,Treppiedi D,Mangili F,Morelli V,Elli FM,Serban AL,Luconi M,Mannelli M,Spada A,Arosio M,Mantovani G,Peverelli E</div> <div itemprop="description">AM4300 was used in Western Blot to test the involvement of cytoskeleton actin-binding protein filamin A in regulating IGF1R and IR responsiveness to both insulin-like growth factor 2 (IGF2) and inhibitors in adrenocortical carcinomas.</div> <div itemprodp="datePublished">Thu Jan 28 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32676663"> <div itemprop="name">AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.</div> </a> <div itemprop="about">Inflammatory bowel diseases</div> <div itemprop="author">Steiner CA,Rodansky ES,Johnson LA,Berinstein JA,Cushing KC,Huang S,Spence JR,Higgins PDR</div> <div itemprop="description">AM4300 was used in Western Blot to study the AXL pathway in activated myofibroblasts implicated in the pathogenesis of fibrosis during Crohn's-related intestinal failure.</div> <div itemprodp="datePublished">Tue Feb 16 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33596994"> <div itemprop="name">BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer.</div> </a> <div itemprop="about">Clinical epigenetics</div> <div itemprop="author">Giles KA,Gould CM,Achinger-Kawecka J,Page SG,Kafer GR,Rogers S,Luu PL,Cesare AJ,Clark SJ,Taberlay PC</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the molecular effects on global transcription programmes.</div> <div itemprodp="datePublished">Wed Feb 17 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34338279"> <div itemprop="name">The exocyst complex regulates C. elegans germline stem cell proliferation by controlling membrane Notch levels.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Pushpa K,Dagar S,Kumar H,Pathak D,Mylavarapu SVS</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal that the exocyst complex regulates C. elegans GSC proliferation by modulating Notch signaling cell autonomously.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33089452"> <div itemprop="name">Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein.</div> </a> <div itemprop="about">Stem cell reviews and reports</div> <div itemprop="author">Ropa J,Cooper S,Capitano ML,Van't Hof W,Broxmeyer HE</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the expression of ACE2, to which SARS-CoV-2 Spike (S) protein binds to facilitate viral entry, in cord blood derived HSCs/HPCs and in peripheral blood derived immune cell subtypes.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34549979"> <div itemprop="name">Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Smith LM,Ladner JT,Hodara VL,Parodi LM,Harris RA,Callery JE,Lai Z,Zou Y,Raveedran M,Rogers J,Giavedoni LD</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that Cas9 nickase in association with gRNA pairs can specifically eliminate parts of the integrated provirus DNA and show that careful design of an all-in-one plasmid coding for 3 gRNAs and Cas9 nuclease inhibits SIV production with undetectable off-target mutations, making these tools a desirable prospect for moving into animal studies.</div> <div itemprodp="datePublished">Tue Nov 09 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33905594"> <div itemprop="name">Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Rössler U,Hennig AF,Stelzer N,Bose S,Kopp J,Søe K,Cyganek L,Zifarelli G,Ali S,von der Hagen M,Strässler ET,Hahn G,Pusch M,Stauber T,Izsvák Z,Gossen M,Stachelscheid H,Kornak U</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate that osteoclasts differentiated from ARO hiPSCs can be used as a disease model for ARO and potentially also other osteoclast-related diseases.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34058047"> <div itemprop="name">Zbtb46-dependent altered developmental program in embryonic stem cell-derived blood cell progenitors.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Boto P,Gerzsenyi TB,Lengyel A,Szunyog B,Szatmari I</div> <div itemprop="description">AM4300 was used in Western Blot to study the effect of the Zbtb46 transcription factor in embryonic stem cell (ESC)-derived blood cell progenitors using chemically inducible mouse cell lines.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34150666"> <div itemprop="name">Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling.</div> </a> <div itemprop="about">Frontiers in oncology</div> <div itemprop="author">Liu H,Wang Z,He J,Li Z,Gao JY,Liu R,Lin P,Yang J</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate the role of myeloma cell-expressed integrin α6 in bone.</div> <div itemprodp="datePublished">Tue Jun 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33536248"> <div itemprop="name">A lamin A/C variant causing striated muscle disease provides insights into filament organization.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Kronenberg-Tenga R,Tatli M,Eibauer M,Wu W,Shin JY,Bonne G,Worman HJ,Medalia O</div> <div itemprop="description">AM4300 was used in Western Blot to investigate nuclear lamina molecular changes occurring in cardiomyopathy and muscular dystrophy using a mouse model.</div> <div itemprodp="datePublished">Mon Mar 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34350936"> <div itemprop="name">A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">McCaughey J,Stevenson NL,Mantell JM,Neal CR,Paterson A,Heesom K,Stephens DJ</div> <div itemprop="description">AM4300 was used in Western Blot to support a general role for MIA3/TANGO1 in maintaining secretory pathway structure and function in vertebrate cells.</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34734627"> <div itemprop="name">A cytosolic reductase pathway is required for efficient N-glycosylation of an STT3B-dependent acceptor site.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">van Lith M,Pringle MA,Fleming B,Gaeta G,Im J,Gilmore R,Bulleid NJ</div> <div itemprop="description">AM4300 was used in Western Blot to study the redox effects of efficient glycosylation in cellular pathways and protein folding.</div> <div itemprodp="datePublished">Mon Nov 15 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34233584"> <div itemprop="name">Triple deletion of <i>TP53, PCNT</i>, and <i>CEP215</i> promotes centriole amplification in the M phase.</div> </a> <div itemprop="about">Cell cycle (Georgetown, Tex.)</div> <div itemprop="author">Jung GI,Rhee K</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal the heterogeneity of the supernumerary centrioles in the triple KO cells.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33705894"> <div itemprop="name">RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.</div> </a> <div itemprop="about">Cellular signalling</div> <div itemprop="author">Wendimu MY,Alqinyah M,Vella S,Dean P,Almutairi F,Davila-Rivera R,Rayatpisheh S,Wohlschlegel J,Moreno S,Hooks SB</div> <div itemprop="description">AM4300 was used in Western Blotting to identify non-canonical RGS10 interacting partners that mediate its anti-inflammatory mechanism.</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33141462"> <div itemprop="name">An epilepsy-associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model.</div> </a> <div itemprop="about">Journal of neuroscience research</div> <div itemprop="author">Ahn LY,Coatti GC,Liu J,Gumus E,Schaffer AE,Miranda HC</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the molecular pathogenesis of ACTL6B p.(Val421_Cys425del) using in silico 3D protein modeling predictions and patient-specific induced pluripotent stem cell-derived neurons.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33129689"> <div itemprop="name">Expanding the clinical and metabolic phenotype of DPM2 deficient congenital disorders of glycosylation.</div> </a> <div itemprop="about">Molecular genetics and metabolism</div> <div itemprop="author">Radenkovic S,Fitzpatrick-Schmidt T,Byeon SK,Madugundu AK,Saraswat M,Lichty A,Wong SYW,McGee S,Kubiak K,Ligezka A,Ranatunga W,Zhang Y,Wood T,Friez MJ,Clarkson K,Pandey A,Jones JR,Morava E</div> <div itemprop="description">AM4300 was used in Western Blot to add to the clinical phenotype of DPM2-congenital disorders of glycosylation and add more insights into the pathomechanism of DPM2-CDG disorder through glycomics and lipidomics analysis.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33757809"> <div itemprop="name">microRNAs (miR 9, 124, 155 and 224) transdifferentiate mouse macrophages to neurons.</div> </a> <div itemprop="about">Experimental cell research</div> <div itemprop="author">Challagundla N,Agrawal-Rajput R</div> <div itemprop="description">AM4300 was used in Western Blot to report a novel approach of microRNA (miR)- induced trans-differentiation of macrophages (CD11b high) to induced neuronal cells (iNCs) (neuronal markershigh- Nestin, Nurr1, Map2, NSE, Tubb3 and Mash1) without exogenous use of transcription factors. miR 9, 124, 155 and 224 successfully transdifferentiated macrophages to neurons with transient stem cell-like phenotype.</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34109436"> <div itemprop="name">Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine‑resistant myeloid leukemia cells.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Tseng YH,Yang RC,Chiou SS,Shieh TM,Shih YH,Lin PC</div> <div itemprop="description">AM4300 was used in Western Blot to investigate whether curcumin induces apoptosis by regulating BCAT1 expression.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34046979"> <div itemprop="name">Integrin α4β1 is required for IL-1α- and Nrf2-dependent, Cox-2 induction in fibroblasts, supporting a mechanism that suppresses α-SMA expression.</div> </a> <div itemprop="about">Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society</div> <div itemprop="author">Zheng R,Varney SD,Wu L,DiPersio CM,Van De Water L</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that fibroblast integrin α4β1 regulates-depending on microenvironmental cues-the differentiated state of fibroblasts through a signalling network in which IL-1α, Cox-2 and Nrf2 participate.</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33030055"> <div itemprop="name">Force dependent effects of chronic overuse on fibrosis-related genes and proteins in skeletal muscles.</div> </a> <div itemprop="about">Connective tissue research</div> <div itemprop="author">Hilliard BA,Amin M,Popoff SN,Barbe MF</div> <div itemprop="description">AM4300 was used in Western Blot to examine the chronic effect of force on mRNA and protein expression levels of fibrosis-related genes in flexor digitorum muscles in a rat model of repetitive overuse injury that induces muscle fibrosis at high force levels.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34940136"> <div itemprop="name">High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats.</div> </a> <div itemprop="about">Current issues in molecular biology</div> <div itemprop="author">Paulo SL,Miranda-Lourenço C,Belo RF,Rodrigues RS,Fonseca-Gomes J,Tanqueiro SR,Geraldes V,Rocha I,Sebastião AM,Xapelli S,Diógenes MJ</div> <div itemprop="description">AM4300 was used in Western Blotting to aim at unravelling the impact of a chronic high caloric diet (HCD) on memory performance and synaptic plasticity in aged rats.</div> <div itemprodp="datePublished">Sat Dec 18 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32658340"> <div itemprop="name">Restricted Water Intake Adversely Affects Rat Vocal Fold Biology.</div> </a> <div itemprop="about">The Laryngoscope</div> <div itemprop="author">Duan C,do Nascimento NC,Calve S,Cox A,Sivasankar MP</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the dehydrating effects of restricted water intake on vocal fold tissue in an in vivo model.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33048315"> <div itemprop="name">Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat.</div> </a> <div itemprop="about">Reproductive sciences (Thousand Oaks, Calif.)</div> <div itemprop="author">Iqbal K,Dhakal P,Pierce SH,Soares MJ</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate Catechol-O-methyltransferase in rat, a species with deep intrauterine trophoblast invasion.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34290289"> <div itemprop="name">Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Methatham T,Tomida S,Kimura N,Imai Y,Aizawa K</div> <div itemprop="description">AM4300 was used in Western Blot to investigate how ICG001 can prevent cardiac hypertrophy and fibrosis induced by transverse aortic constriction (TAC).</div> <div itemprodp="datePublished">Wed Jul 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34315531"> <div itemprop="name">Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Jeong A,Cheng S,Zhong R,Bennett DA,Bergö MO,Li L</div> <div itemprop="description">AM4300 was used in Western Blot to suggest that aberrant upregulation of protein farnesylation is an early driving force in the pathogenic cascade of AD and that targeting FT or its downstream signaling pathways presents a viable therapeutic strategy against AD.</div> <div itemprodp="datePublished">Tue Jul 27 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34429148"> <div itemprop="name">Acute depletion of CTCF rewires genome-wide chromatin accessibility.</div> </a> <div itemprop="about">Genome biology</div> <div itemprop="author">Xu B,Wang H,Wright S,Hyle J,Zhang Y,Shao Y,Niu M,Fan Y,Rosikiewicz W,Djekidel MN,Peng J,Lu R,Li C</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the effects of CTCF on chromatin topology using Cut&Run.</div> <div itemprodp="datePublished">Tue Aug 24 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34773084"> <div itemprop="name">Image-based high-throughput mapping of TGF-β-induced phosphocomplexes at a single-cell level.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Lönn P,Al-Amin RA,Doulabi EM,Heldin J,Gallini R,Björkesten J,Oelrich J,Kamali-Moghaddam M,Landegren U</div> <div itemprop="description">AM4300 was used in Western Blot to investigate cell cycle progression and local cell crowding in relation to TGF-β-responsive Smad2 linker phosphorylations and complex formations over time.</div> <div itemprodp="datePublished">Fri Nov 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34988393"> <div itemprop="name">Generation and analysis of innovative genomically humanized knockin <i>SOD1</i>, <i>TARDBP</i> (TDP-43), and <i>FUS</i> mouse models.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Devoy A,Price G,De Giorgio F,Bunton-Stasyshyn R,Thompson D,Gasco S,Allan A,Codner GF,Nair RR,Tibbit C,McLeod R,Ali Z,Noda J,Marrero-Gagliardi A,Brito-Armas JM,Williams C,Öztürk MM,Simon M,O'Neill E,Bryce-Smith S,Harrison J,Atkins G,Corrochano S,Stewart M,Gilthorpe JD,Teboul L,Acevedo-Arozena A,Fisher EMC,Cunningham TJ</div> <div itemprop="description">AM4300 was used in Western Blot to establish a new standard of large knockin allele quality control, demonstrating the utility of indirect capture for enrichment of a genomic region of interest followed by Oxford Nanopore sequencing.</div> <div itemprodp="datePublished">Fri Dec 17 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34832855"> <div itemprop="name">Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation.</div> </a> <div itemprop="about">Pharmaceuticals (Basel, Switzerland)</div> <div itemprop="author">Kodji X,Kee Z,McKenna R,de Sousa Valente J,Ravenscroft H,McMillan H,Gamble J,Dombrowski Y,Moynagh P,Brough D,Lundy FT,Brain SD,El Karim IA</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the role of transient receptor potential ankyrin 1 (TRPA1) in murine temporomandibular joint (TMJ) inflammatory hyperalgesia and the influence of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome.</div> <div itemprodp="datePublished">Sat Oct 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35004352"> <div itemprop="name">Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to <i>Francisella tularensis</i>.</div> </a> <div itemprop="about">Frontiers in cellular and infection microbiology</div> <div itemprop="author">Mohammadi N,Lindgren H,Yamamoto M,Martin A,Henry T,Sjöstedt A</div> <div itemprop="description">AM4300 was used in Western Blot to assess the responses of bone marrow derived murine macrophages and guanylate-binding protein deficient bone marrow derived murine macrophages to Francisella tularensis strains of variable virulence.</div> <div itemprodp="datePublished">Fri Jan 28 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34903048"> <div itemprop="name">Human Cytomegalovirus UL138 Protein Inhibits the STING Pathway and Reduces Interferon Beta mRNA Accumulation during Lytic and Latent Infections.</div> </a> <div itemprop="about">mBio</div> <div itemprop="author">Albright ER,Mickelson CK,Kalejta RF</div> <div itemprop="description">AM4300 was used in Western Blotting to show that the latency-associated protein UL138 inhibits the cGAS/STING/TBK1 innate immunity pathway during transfections and infections, in fully differentiated cells and incompletely differentiated myeloid cells, and with loss of function and restoration of function approaches.</div> <div itemprodp="datePublished">Tue Dec 21 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34852229"> <div itemprop="name">Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Switonski PM,Delaney JR,Bartelt LC,Niu C,Ramos-Zapatero M,Spann NJ,Alaghatta A,Chen T,Griffin EN,Bapat J,Sopher BL,La Spada AR</div> <div itemprop="description">AM4300 was used in Western Blotting to conclude that altered DNA repair function in SCA7 may predispose the subject to excessive DNA damage, leading to neuron demise and highlights DNA repair as a therapy target.</div> <div itemprodp="datePublished">Tue Nov 30 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34533188"> <div itemprop="name">CREB regulates the expression of type 1 inositol 1,4,5-trisphosphate receptors.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Arige V,Terry LE,Malik S,Knebel TR,Wagner Ii LE,Yule DI</div> <div itemprop="description">AM4300 was used in Western Blotting to report a crucial role for CREB in governing both the expression and correct localization of IP3R1.</div> <div itemprodp="datePublished">Fri Oct 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34680104"> <div itemprop="name">AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins.</div> </a> <div itemprop="about">Biomolecules</div> <div itemprop="author">Thieffry C,Van Wynendaele M,Aynaci A,Maja M,Dupuis C,Loriot A,Marbaix E,Henriet P</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the specificity of AG-205 as a PGRMC1 inhibitor.</div> <div itemprodp="datePublished">Wed Oct 06 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33776760"> <div itemprop="name">Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Zhang Q,Long J,Li N,Ma X,Zheng L</div> <div itemprop="description">AM4300 was used in Western Blot to suggest that the overexpression of circ_CLASP2 protected HUVEC from HG-induced dysfunction at least partly through the regulation of the miR-140-5p/FBXW7 axis.</div> <div itemprodp="datePublished">Tue Mar 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34064336"> <div itemprop="name">Effect of Microbial Status on Hepatic Odd-Chain Fatty Acids Is Diet-Dependent.</div> </a> <div itemprop="about">Nutrients</div> <div itemprop="author">Weitkunat K,Bishop CA,Wittmüss M,Machate T,Schifelbein T,Schulze MB,Klaus S</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the effect of increasing microbiota complexity on hepatic lipid metabolism and odd-chain fatty acids levels in different dietary settings.</div> <div itemprodp="datePublished">Tue May 04 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33892772"> <div itemprop="name">Drosophila primary microRNA-8 encodes a microRNA-encoded peptide acting in parallel of miR-8.</div> </a> <div itemprop="about">Genome biology</div> <div itemprop="author">Montigny A,Tavormina P,Duboe C,San Clémente H,Aguilar M,Valenti P,Lauressergues D,Combier JP,Plaza S</div> <div itemprop="description">AM4300 was used in Western Blot to reveal that several Drosophila pri-miRs exhibit translation potential. Contrasting with the mechanism described in plants, these data shed light on the function of yet undescribed primary-microRNA-encoded peptides in Drosophila and their regulatory potential on genome expression.</div> <div itemprodp="datePublished">Fri Apr 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34359864"> <div itemprop="name">Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Verma DK,Seo BA,Ghosh A,Ma SX,Hernandez-Quijada K,Andersen JK,Ko HS,Kim YH</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that PFF-induced pathology could lead to astrocyte and/or microglia senescence in PD brains, which may contribute to neuropathology in this model.</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33614825"> <div itemprop="name">AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS.</div> </a> <div itemprop="about">Molecular therapy. Methods & clinical development</div> <div itemprop="author">Eykens C,Rossaert E,Duqué S,Rué L,Bento-Abreu A,Hersmus N,Lenaerts A,Kerstens A,Corthout N,Munck S,Van Damme P,Holt MG,von Jonquires G,Klugmann M,Van Den Bosch L,Robberecht W</div> <div itemprop="description">AM4300 was used in Western Blot to increase our current understanding about the complex nature of oligodendrocyte pathology in ALS and provides valuable insights into the future development of therapeutic strategies to efficiently modulate these cells.</div> <div itemprodp="datePublished">Fri Mar 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34588982"> <div itemprop="name">Renoprotective Effects of Maslinic Acid on Experimental Renal Fibrosis in Unilateral Ureteral Obstruction Model via Targeting MyD88.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Sun W,Byon CH,Kim DH,Choi HI,Park JS,Joo SY,Kim IJ,Jung I,Bae EH,Ma SK,Kim SW</div> <div itemprop="description">AM4300 was used in Western Blot to clarify whether maslinic acid could attenuate renal fibrosis and determine the putative underlying molecular mechanisms.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33542378"> <div itemprop="name">The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Sangeetham SB,Engelke AD,Fodor E,Krausz SL,Tatzelt J,Welker E</div> <div itemprop="description">AM4300 was used in Western Blot to show that while molecular dynamics may capture the features affecting dimerization in vitro, G127V inhibiting dimer formation of PrP, these are not evidenced in a more complex cellular system.</div> <div itemprodp="datePublished">Thu Feb 04 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35008496"> <div itemprop="name">Loss of αA or αB-Crystallin Accelerates Photoreceptor Cell Death in a Mouse Model of P23H Autosomal Dominant Retinitis Pigmentosa.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Wang T,Yao J,Jia L,Fort PE,Zacks DN</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest an important role for the ?-crystallins in regulating photoreceptor survival in the P23H-RHO mouse model of IRD.</div> <div itemprodp="datePublished">Wed Dec 22 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34503072"> <div itemprop="name">Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43<sub>266-283</sub> in Glioblastoma Stem Cells.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Pelaz SG,Ollauri-Ibáñez C,Lillo C,Tabernero A</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that the antitumor peptide TAT-Cx43266-283, a c-Src inhibitor, blocks autophagic flux in glioblastoma stem cells (GSCs) under basal and nutrient-deprived conditions.</div> <div itemprodp="datePublished">Tue Aug 24 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34233184"> <div itemprop="name">Targeting senescent cells improves functional recovery after spinal cord injury.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Paramos-de-Carvalho D,Martins I,Cristóvão AM,Dias AF,Neves-Silva D,Pereira T,Chapela D,Farinho A,Jacinto A,Saúde L</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the role of persistent senescent cells in the regeneration of the spinal cord in mammals.</div> <div itemprodp="datePublished">Tue Jul 06 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34162925"> <div itemprop="name">Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Williams AL,Walton CB,Pinell B,Khadka VS,Dunn B,Lee K,Anagaran MCT,Avelar A,Shohet RV</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that loss of CaMK2γ after MI is HIF1-dependent and may play an important role in the heart's calcium signaling and transcriptional response to hypoxia.</div> <div itemprodp="datePublished">Wed Jun 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34778243"> <div itemprop="name">Tet1 Regulates Astrocyte Development and Cognition of Mice Through Modulating GluA1.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Xu W,Zhang X,Liang F,Cao Y,Li Z,Qu W,Zhang J,Bi Y,Sun C,Zhang J,Sun B,Shu Q,Li X</div> <div itemprop="description">AM4300 was used in Western Blotting to show that Tet1 deficiency alters astrocyte morphology and impairs neuronal function.</div> <div itemprodp="datePublished">Wed Nov 17 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33604582"> <div itemprop="name">Biochemical detection of capsid in the nucleus during HIV-1 infection.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Selyutina A,Diaz-Griffero F</div> <div itemprop="description">AM4300 was used in Western Blotting to develop a protocol to biochemically track capsid in the nucleus during infection.</div> <div itemprodp="datePublished">Fri Mar 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33604582"> <div itemprop="name">Biochemical detection of capsid in the nucleus during HIV-1 infection.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Selyutina A,Diaz-Griffero F</div> <div itemprop="description">AM4300 was used in Western Blotting to develop a protocol to biochemically track capsid in the nucleus during infection.</div> <div itemprodp="datePublished">Fri Mar 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33639418"> <div itemprop="name">Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.</div> </a> <div itemprop="about">Molecular & cellular proteomics : MCP</div> <div itemprop="author">Swovick K,Firsanov D,Welle KA,Hryhorenko JR,Wise JP,George C,Sformo TL,Seluanov A,Gorbunova V,Ghaemmaghami S</div> <div itemprop="description">AM4300 was used in Western Blot to suggest that in lieu of a rapid constitutive turnover, long-lived species may have evolved more energetically efficient mechanisms for selective detection and clearance of damaged proteins.</div> <div itemprodp="datePublished">Fri Mar 11 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34168290"> <div itemprop="name">TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Nakasuka F,Tabata S,Sakamoto T,Hirayama A,Ebi H,Yamada T,Umetsu K,Ohishi M,Ueno A,Goto H,Sugimoto M,Nishioka Y,Yamada Y,Tomita M,Sasaki AT,Yano S,Soga T</div> <div itemprop="description">AM4300 was used in Western Blot to show that TGF-β induces reprogramming of intracellular amino acid metabolism, which is necessary to promote EMT in non-small cell lung cancer cells.</div> <div itemprodp="datePublished">Thu Jun 24 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34551299"> <div itemprop="name">DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Du Q,Smith GC,Luu PL,Ferguson JM,Armstrong NJ,Caldon CE,Campbell EM,Nair SS,Zotenko E,Gould CM,Buckley M,Chia KM,Portman N,Lim E,Kaczorowski D,Chan CL,Barton K,Deveson IW,Smith MA,Powell JE,Skvortsova K,Stirzaker C,Achinger-Kawecka J,Clark SJ</div> <div itemprop="description">AM4300 was used in Western Blot to highlight a potential role for the methylome in the maintenance of 3D genome regulation.</div> <div itemprodp="datePublished">Tue Sep 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33534863"> <div itemprop="name">Pten regulates collagen fibrillogenesis by fibroblasts through SPARC.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Jones CE,Sharick JT,Colbert SE,Shukla VC,Zent JM,Ostrowski MC,Ghadiali SN,Sizemore ST,Leight JL</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the mechanism connecting PTEN loss to increased mammary collagen deposition in breast cancer.</div> <div itemprodp="datePublished">Wed Jul 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34962957"> <div itemprop="name">14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Lee GS,Zhang J,Wu Y,Zhou Y</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate NMDARs in mouse brains.</div> <div itemprodp="datePublished">Tue Jan 18 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33772081"> <div itemprop="name">MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Batlle C,Calvo I,Iglesias V,J Lynch C,Gil-Garcia M,Serrano M,Ventura S</div> <div itemprop="description">AM4300 was used in Western Blot to show that amyloid formation by human prion-like proteins can follow the coiled-coil-mediated model reported in yeast and that the amyloid and prion-like properties of MED15 are conserved across species.</div> <div itemprodp="datePublished">Fri Mar 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33300198"> <div itemprop="name">TGF-β acts as a dual regulator of COX-2/PGE<sub>2</sub> tumor promotion depending of its cross-interaction with H-Ras and Wnt/β-catenin pathways in colorectal cancer cells.</div> </a> <div itemprop="about">Cell biology international</div> <div itemprop="author">de Araújo WM,Tanaka MN,Lima PHS,de Moraes CF,Leve F,Bastos LG,Rocha MR,Robbs BK,Viola JPB,Morgado-Diaz JA</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role played by TGF-β, Ras oncogene and COX-2 in colorectal cancer cell lines.</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34280810"> <div itemprop="name">CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells.</div> </a> <div itemprop="about">Virology</div> <div itemprop="author">Inturi R,Jemth P</div> <div itemprop="description">AM4300 was used in Western Blotting to report that CRISPR/Cas9-based knockout of E6 or E7 can trigger cellular senescence in HPV18 immortalized HeLa cells.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33431410"> <div itemprop="name">Bisphenol A promotes stress granule assembly and modulates the integrated stress response.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Fay MM,Columbo D,Cotter C,Friend C,Henry S,Hoppe M,Karabelas P,Lamy C,Lawell M,Monteith S,Noyes C,Salerno P,Wu J,Zhang HM,Anderson PJ,Kedersha N,Ivanov P,Farny NG</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that high-dose BPA causes stress granules (SGs) in human cells.</div> <div itemprodp="datePublished">Sun Jan 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34768807"> <div itemprop="name">Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Babagana M,Brown LR,Slabodkin HZ,Kichina JV,Kandel ES</div> <div itemprop="description">AM4300 was used in Western Blot to suggest that proteotoxic stress conferred by hyperactive AKT represents a targetable vulnerability, which can be exploited by either elevating the stress above the level tolerated by such cells or by eliminating the factors that enable such tolerance.</div> <div itemprodp="datePublished">Thu Oct 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33615198"> <div itemprop="name">Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Someya S,Tohyama S,Kameda K,Tanosaki S,Morita Y,Sasaki K,Kang MI,Kishino Y,Okada M,Tani H,Soma Y,Nakajima K,Umei T,Sekine O,Moriwaki T,Kanazawa H,Kobayashi E,Fujita J,Fukuda K</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate that TRP is indispensable for survival and proliferation of hPSCs. A deeper understanding of TRP metabolism will enable cost-effective large-scale production of hPSCs, leading to advances in regenerative medicine.</div> <div itemprodp="datePublished">Fri Feb 19 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33440165"> <div itemprop="name">MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Philips T,Mironova YA,Jouroukhin Y,Chew J,Vidensky S,Farah MH,Pletnikov MV,Bergles DE,Morrison BM,Rothstein JD</div> <div itemprop="description">AM4300 was used in Western Blot to show that loss of OL lineage MCT1 expression with aging leads to significant axonal degeneration with concomitant hypomyelination.</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34556638"> <div itemprop="name">TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Woznicki JA,Saini N,Flood P,Rajaram S,Lee CM,Stamou P,Skowyra A,Bustamante-Garrido M,Regazzoni K,Crawford N,McDade SS,Longley DB,Aza-Blanc P,Shanahan F,Zulquernain SA,McCarthy J,Melgar S,McRae BL,Nally K</div> <div itemprop="description">AM4300 was used in Western Blot to identify JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human IECs by IFN-γ/TNF-α.</div> <div itemprodp="datePublished">Thu Sep 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33730569"> <div itemprop="name">Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Anastasia I,Ilacqua N,Raimondi A,Lemieux P,Ghandehari-Alavijeh R,Faure G,Mekhedov SL,Williams KJ,Caicci F,Valle G,Giacomello M,Quiroga AD,Lehner R,Miksis MJ,Toth K,de Aguiar Vallim TQ,Koonin EV,Scorrano L,Pellegrini L</div> <div itemprop="description">AM4300 was used in Western Blot to study mitochondria-rER contacts in vivo to elucidate their ultrastructural organization, dynamics, and functions.</div> <div itemprodp="datePublished">Tue Mar 16 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34133054"> <div itemprop="name">The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Huebschman JL,Davis MC,Tovar Pensa C,Guo Y,Smith LN</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that FMRP facilitates adjustments in drug self-administration behavior that generally serve to preserve reinforcement level, and combined with our similar IVSA findings in Arc KO mice may implicate Arc, along with FMRP, in behavioral shifts that occur in drug taking when drug availability is altered.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33815280"> <div itemprop="name">Novel Compound Heterozygous Pathogenic Mutations of <i>SLC5A5</i> in a Chinese Patient With Congenital Hypothyroidism.</div> </a> <div itemprop="about">Frontiers in endocrinology</div> <div itemprop="author">Zhang CX,Zhang JX,Yang L,Zhang CR,Cheng F,Zhang RJ,Fang Y,Wang Z,Wu FY,Li PZ,Liang J,Li R,Song HD</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the expression and cellular localization of the novel compound heterozygous mutation in SLC5A5. The functional activity of the mutants was further examined in vitro.</div> <div itemprodp="datePublished">Fri Dec 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34485278"> <div itemprop="name">The Effects of Maternal Smoking on Pregnancy and Offspring: Possible Role for EGF?</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Janbazacyabar H,van Daal M,Leusink-Muis T,van Ark I,Garssen J,Folkerts G,van Bergenhenegouwen J,Braber S</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal that maternal smoke exposure predisposes dams to exacerbated airway inflammation and offspring to exacerbated immune responses and both phenomena are associated with elevated EGF concentrations.</div> <div itemprodp="datePublished">Tue Sep 07 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34031359"> <div itemprop="name">Pericentromeric Satellite III transcripts induce etoposide resistance.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Kanne J,Hussong M,Isensee J,Muñoz-López Á,Wolffgramm J,Heß F,Grimm C,Bessonov S,Meder L,Wang J,Reinhardt HC,Odenthal M,Hucho T,Büttner R,Summerer D,Schweiger MR</div> <div itemprop="description">AM4300 was used in Western Blotting to e show that the long non-coding satellite III RNA (SatIII) generates resistance against the topoisomerase IIa (TOP2A) inhibitor etoposide in lung cancer.</div> <div itemprodp="datePublished">Mon May 24 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34259631"> <div itemprop="name">Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Dalal JS,Winden KD,Salussolia CL,Sundberg M,Singh A,Pham TT,Zhou P,Pu WT,Miller MT,Sahin M</div> <div itemprop="description">AM4300 was used in Western Blot to implicate dysfunction of FMRP and its targets in TSC and suggest that treatments aimed at restoring the function of these pathways may be beneficial.</div> <div itemprodp="datePublished">Wed Jul 14 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34593029"> <div itemprop="name">Loss of presenilin function enhances tau phosphorylation and aggregation in mice.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Soto-Faguás CM,Sanchez-Molina P,Saura CA</div> <div itemprop="description">AM4300 was used in Immunohistochemistry to report that neuronal presenilin deficiency in conditional knockout (cKO) mice results in age-dependent brain atrophy, inflammatory responses and accumulation of pathological tau in neurons and glial cells.</div> <div itemprodp="datePublished">Thu Sep 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34877494"> <div itemprop="name">STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Morozzi G,Rothen J,Toussaint G,De Lange K,Westritschnig K,Doelemeyer A,Ueberschlag VP,Kahle P,Lambert C,Obrecht M,Beckmann N,Ritter V,Panesar M,Stauffer D,Garnier I,Mueller M,Guerini D,Keller CG,Knehr J,Roma G,Bidinosti M,Brachat S,Morvan F,Fornaro M</div> <div itemprop="description">AM4300 was used in Western Blot to investigate relationship between peripheral nerve injury and inflammation.</div> <div itemprodp="datePublished">Fri Dec 17 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34173818"> <div itemprop="name">MATR3 haploinsufficiency and early-onset neurodegeneration.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Zech M,Seibt A,Zumbaum B,Klee D,Meitinger T,Winkelmann J,Mayatepek E,Wagner M,Distelmaier F</div> <div itemprop="description">AM4300 was used in Western Blotting to discuss MATR3 haploinsufficiency and early-onset neurodegeneration.</div> <div itemprodp="datePublished">Fri Oct 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33314217"> <div itemprop="name">A conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Martina JA,Guerrero-Gómez D,Gómez-Orte E,Antonio Bárcena J,Cabello J,Miranda-Vizuete A,Puertollano R</div> <div itemprop="description">AM4300 was used in Western Blotting to study a novel mechanism of TFEB/HLH-30 regulation through a cysteine-mediated redox switch.</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33916001"> <div itemprop="name">Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer's Disease.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Shukla PK,Delotterie DF,Xiao J,Pierre JF,Rao R,McDonald MP,Khan MM</div> <div itemprop="description">AM4300 was used in Western Blotting to provide a potential mechanistic link between dysbiotic gut microbiota and neuroinflammation associated with AD progression.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32238925"> <div itemprop="name">CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Han K,Pierce SE,Li A,Spees K,Anderson GR,Seoane JA,Lo YH,Dubreuil M,Olivas M,Kamber RA,Wainberg M,Kostyrko K,Kelly MR,Yousefi M,Simpkins SW,Yao D,Lee K,Kuo CJ,Jackson PK,Sweet-Cordero A,Kundaje A,Gentles AJ,Curtis C,Winslow MM,Bassik MC</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal key differences between 2D and 3D cancer models, and establish a generalizable strategy for performing CRISPR screens in spheroids to reveal cancer vulnerabilities.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31839405"> <div itemprop="name">Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores.</div> </a> <div itemprop="about">Molecular cell</div> <div itemprop="author">Drexler HL,Choquet K,Churchman LS</div> <div itemprop="description">AM4300 was used in Western Blotting to conclude that nano-COP unveils the organizational complexity of RNA processing.</div> <div itemprodp="datePublished">Thu Mar 05 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32673563"> <div itemprop="name">G<sub>4</sub>C<sub>2</sub> Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Coyne AN,Zaepfel BL,Hayes L,Fitchman B,Salzberg Y,Luo EC,Bowen K,Trost H,Aigner S,Rigo F,Yeo GW,Harel A,Svendsen CN,Sareen D,Rothstein JD</div> <div itemprop="description">AM4300 was used in Western Blot to suggest that the expression of expanded C9orf72 ALS/FTD repeat RNA alone affects nuclear POM121 expression in the initiation of a pathological cascade affecting nucleoporin levels within neuronal nuclei and ultimately downstream neuronal survival.</div> <div itemprodp="datePublished">Wed Sep 23 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32438408"> <div itemprop="name">Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Lim TJF,Bunjamin M,Ruedl C,Su IH</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the role and mechanism of Talin in regulating skin dendritic cells (DCs) during inflammatory responses.</div> <div itemprodp="datePublished">Mon Aug 03 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31604808"> <div itemprop="name">Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Xu J,Chen J,Li W,Lian W,Huang J,Lai B,Li L,Huang Z</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the effect of overexpressing IL-37 on the therapeutic effects of mesenchymal stem cells for Systemic Lupus Erythematosus treatment.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32845033"> <div itemprop="name">Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Klemm T,Ebert G,Calleja DJ,Allison CC,Richardson LW,Bernardini JP,Lu BG,Kuchel NW,Grohmann C,Shibata Y,Gan ZY,Cooney JP,Doerflinger M,Au AE,Blackmore TR,van der Heden van Noort GJ,Geurink PP,Ovaa H,Newman J,Riboldi-Tunnicliffe A,Czabotar PE,Mitchell JP,Feltham R,Lechtenberg BC,Lowes KN,Dewson G,Pellegrini M,Lessene G,Komander D</div> <div itemprop="description">AM4300 was used in Western Blot to identify papain-like protease domain inhibitors for potential antiviral activity in SARS-CoV-2 infection.</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32959911"> <div itemprop="name">Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Konishi H,Okamoto T,Hara Y,Komine O,Tamada H,Maeda M,Osako F,Kobayashi M,Nishiyama A,Kataoka Y,Takai T,Udagawa N,Jung S,Ozato K,Tamura T,Tsuda M,Yamanaka K,Ogi T,Sato K,Kiyama H</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that astrocytes, rather than nonmicroglial mononuclear cells, readily phagocytose microglial debris in our microglia ablation model.</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33106424"> <div itemprop="name">USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Zhang T,Periz G,Lu YN,Wang J</div> <div itemprop="description">AM4300 was used in Western Blotting to report the identification of a ubiquitin-specific protease, USP7, as a regulatory switch in a protein quality-control system that defends against proteotoxicity.</div> <div itemprodp="datePublished">Tue Nov 10 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32004447"> <div itemprop="name">Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.</div> </a> <div itemprop="about">American journal of human genetics</div> <div itemprop="author">Wagner M,Skorobogatko Y,Pode-Shakked B,Powell CM,Alhaddad B,Seibt A,Barel O,Heimer G,Hoffmann C,Demmer LA,Perilla-Young Y,Remke M,Wieczorek D,Navaratnarajah T,Lichtner P,Klee D,Shamseldin HE,Al Mutairi F,Mayatepek E,Strom T,Meitinger T,Alkuraya FS,Anikster Y,Saltiel AR,Distelmaier F</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that the dysregulation of the RalA pathway has an important impact on neuronal function and brain development.</div> <div itemprodp="datePublished">Thu Feb 06 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33049094"> <div itemprop="name">Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Moore TM,Zhou Z,Strumwasser AR,Cohn W,Lin AJ,Cory K,Whitney K,Ho T,Ho T,Lee JL,Rucker DH,Hoang AN,Widjaja K,Abrishami AD,Charugundla S,Stiles L,Whitelegge JP,Turcotte LP,Wanagat J,Hevener AL</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the dynamics and quality control signaling in mouse muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32599451"> <div itemprop="name">MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells.</div> </a> <div itemprop="about">Molecular therapy. Nucleic acids</div> <div itemprop="author">Mak HK,Yung JSY,Weinreb RN,Ng SH,Cao X,Ho TYC,Ng TK,Chu WK,Yung WH,Choy KW,Wang CC,Lee TL,Leung CK</div> <div itemprop="description">AM4300 was used in Western Blotting to uncover a previously unrecognised involvement of the miR-19a-PTEN axis in RGC axon regeneration, and it demonstrates therapeutic potential of microRNA-mediated restoration of axon regenerative capacity in optic neuropathies.</div> <div itemprodp="datePublished">Fri Sep 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31796949"> <div itemprop="name">Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation.</div> </a> <div itemprop="about">Journal of Crohn's & colitis</div> <div itemprop="author">Rees WD,Stahl M,Jacobson K,Bressler B,Sly LM,Vallance BA,Steiner TS</div> <div itemprop="description">AM4300 was used in Western Blot to test a hypothesis that ER stress changes innate signalling in human IECs, augmenting toll-like receptor [TLR] responses and inducing pro-inflammatory changes in underlying dendritic cells [DCs].</div> <div itemprodp="datePublished">Thu Jul 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32291314"> <div itemprop="name">Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies.</div> </a> <div itemprop="about">Science signaling</div> <div itemprop="author">Pereira EJ,Burns JS,Lee CY,Marohl T,Calderon D,Wang L,Atkins KA,Wang CC,Janes KA</div> <div itemprop="description">AM4300 was used in Western Blotting to findd that cellular states was jointly coordinated by the NRF2 and p53 pathways, which are costabilized by spontaneous oxidative stress within 3D cultures.</div> <div itemprodp="datePublished">Tue Apr 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32461223"> <div itemprop="name">Quantitative analysis of Y-Chromosome gene expression across 36 human tissues.</div> </a> <div itemprop="about">Genome research</div> <div itemprop="author">Godfrey AK,Naqvi S,Chmátal L,Chick JM,Mitchell RN,Gygi SP,Skaletsky H,Page DC</div> <div itemprop="description">AM4300 was used in Western Blotting to analyze quantitative profiles of Y-Chromosome gene expression across 36 human tissues from hundreds of individuals.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31730284"> <div itemprop="name">Recombinant human ADAMTS13 treatment and anti-NET strategies enhance skin allograft survival in mice.</div> </a> <div itemprop="about">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</div> <div itemprop="author">Wong SL,Goverman J,Staudinger C,Wagner DD</div> <div itemprop="description">AM4300 was used in Western Blotting to explore the effect of ADAMTS13 treatment and the impact of NETs on skin allografts.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31723239"> <div itemprop="name">Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Kim YS,Gupta Vallur P,Jones VM,Worley BL,Shimko S,Shin DH,Crawford LC,Chen CW,Aird KM,Abraham T,Shepherd TG,Warrick JI,Lee NY,Phaeton R,Mythreye K,Hempel N</div> <div itemprop="description">AM4300 was used in Western Blotting to highlight the novel context-specific, pro-metastatic role of SIRT3 in ovarian cancer.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32289147"> <div itemprop="name">Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Au FKC,Hau BKT,Qi RZ</div> <div itemprop="description">AM4300 was used in Immunocytochemistry to show that GAS2L1, a microtubule- and F-actin-binding protein required for centrosome disjunction, undergoes Nek2-mediated phosphorylation at Ser352 in G2/M.</div> <div itemprodp="datePublished">Mon May 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31865373"> <div itemprop="name">Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Collins KB,Kang H,Matsche J,Klomp JE,Rehman J,Malik AB,Karginov AV</div> <div itemprop="description">AM4300 was used in Western Blot to inestigate if targeting of Septin2-mediated podosome formation is a potentially attractive anti-angiogenesis strategy.</div> <div itemprodp="datePublished">Mon Feb 03 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31913659"> <div itemprop="name">Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.</div> </a> <div itemprop="about">American journal of respiratory cell and molecular biology</div> <div itemprop="author">Wang Y,Wang R,Tang DD</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that SLK regulates paxillin phosphorylation at Ser-272 via Plk1, which modulates N-WASP activation and actin polymerization in smooth muscle. SLK-mediated actin cytoskeletal reorganization may facilitate force transmission between the contractile units and the extracellular matrix.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31456217"> <div itemprop="name">Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation.</div> </a> <div itemprop="about">International journal of cancer</div> <div itemprop="author">Mallm JP,Windisch P,Biran A,Gal Z,Schumacher S,Glass R,Herold-Mende C,Meshorer E,Barbus M,Rippe K</div> <div itemprop="description">AM4300 was used in Western Blot to identify stem cell-like chromatin features in human glioblastoma initiating cells (GICs) and link them to a loss of the repressive histone H3 lysine 9 trimethylation (H3K9me3) mark.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32774677"> <div itemprop="name">Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells.</div> </a> <div itemprop="about">Oxidative medicine and cellular longevity</div> <div itemprop="author">Abokyi S,Shan SW,To CH,Chan HH,Tse DY</div> <div itemprop="description">AM4300 was used in Western Blotting to support the transcriptional upregulation of TFEB and autophagy by trehalose and its protection against HQ-induced oxidative damage in RPE cells.</div> <div itemprodp="datePublished">Fri May 14 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32798727"> <div itemprop="name">Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Miranda-Lourenço C,Duarte ST,Palminha C,Gaspar C,Rodrigues TM,Magalhães-Cardoso T,Rei N,Colino-Oliveira M,Gomes R,Ferreira S,Rosa J,Xapelli S,Armstrong J,García-Cazorla À,Correia-de-Sá P,Sebastião AM,Diógenes MJ</div> <div itemprop="description">AM4300 was used in Western Blotting to characterize several hallmarks of the adenosinergic and BDNF signalling in RTT and explore whether A2AR activation could boost BDNF actions.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32611603"> <div itemprop="name">Ykt6-dependent endosomal recycling is required for Wnt secretion in the <i>Drosophila</i> wing epithelium.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Linnemannstöns K,Witte L,Karuna M P,Kittel JC,Danieli A,Müller D,Nitsch L,Honemann-Capito M,Grawe F,Wodarz A,Gross JC</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate how Wnts are sorted at the level of endosomes by the versatile v-SNARE Ykt6.</div> <div itemprodp="datePublished">Fri Aug 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33139402"> <div itemprop="name">Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Qu W,Li L</div> <div itemprop="description">AM4300 was used in Western Blot to unveil the positive impacts of TREM2 deficiency on cognitive and synaptic function during aging and suggest that TREM2 may exert detrimental effects on neuronal function.</div> <div itemprodp="datePublished">Wed Dec 09 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32699090"> <div itemprop="name">Antiviral Properties of the LSD1 Inhibitor SP-2509.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Harancher MR,Packard JE,Cowan SP,DeLuca NA,Dembowski JA</div> <div itemprop="description">AM4300 was used in Western Blotting to support a potential new role for LSD1 in the regulation of viral DNA replication and successive steps in the virus life cycle, and further highlight the promising potential to utilize LSD1 inhibition as an antiviral approach.</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32241872"> <div itemprop="name">Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity.</div> </a> <div itemprop="about">Molecular cancer therapeutics</div> <div itemprop="author">Kotanides H,Sattler RM,Lebron MB,Carpenito C,Shen J,Li J,Surguladze D,Haidar JN,Burns C,Shen L,Inigo I,Pennello AL,Forest A,Chen X,Chin D,Sonyi A,Topper M,Boucher L,Sharma P,Zhang Y,Burtrum D,Novosiadly RD,Ludwig DL,Plowman GD,Kalos M</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate 7A5 is a differentiated CD137 agonist antibody with biological properties that warrant its further development as a cancer immunotherapy.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32506644"> <div itemprop="name">The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Bishop CA,Schulze MB,Klaus S,Weitkunat K</div> <div itemprop="description">AM4300 was used in Western Blotting to show the differential roles of branched-chain amino acids in lipid metabolism and endogenous formation of circulating odd-chain fatty acids is exclusively mediated by valine.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31958463"> <div itemprop="name">Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53.</div> </a> <div itemprop="about">Journal of molecular and cellular cardiology</div> <div itemprop="author">Haywood ME,Cocciolo A,Porter KF,Dobrinskikh E,Slavov D,Graw SL,Reece TB,Ambardekar AV,Bristow MR,Mestroni L,Taylor MRG</div> <div itemprop="description">AM4300 was used in Western Blotting to identify transcriptome signatures and enriched pathways in the hearts of dilated cardiomyopathy (DCM) patients with ventricular tachycardia (VT).</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31653714"> <div itemprop="name">An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21.</div> </a> <div itemprop="about">RNA (New York, N.Y.)</div> <div itemprop="author">McRae EKS,Dupas SJ,Booy EP,Piragasam RS,Fahlman RP,McKenna SA</div> <div itemprop="description">AM4300 was used in Western Blotting to identify the role of DDX21 in regulation at the translational level through biologically relevant rG4 and show that MAGED2 protein levels are regulated, at least in part, by the potential to form rG4 in their 5'-UTRs.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32951327"> <div itemprop="name">Neuropilin-1 is up-regulated by cancer-associated fibroblast-secreted IL-8 and associated with cell proliferation of gallbladder cancer.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Chen C,Zhang R,Ma L,Li Q,Zhao YL,Zhang GJ,Zhang D,Li WZ,Cao S,Wang L,Geng ZM</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate how Neuropilin-1 causes gallbladder cancer cell proliferation through upregulation by cancer-associated fibroblast-secreted IL-8.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32393599"> <div itemprop="name">Abl-mediated PI3K activation regulates macrophage podosome formation.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Zhou Y,Feng Z,Cao F,Liu X,Xia X,Yu CH</div> <div itemprop="description">AM4300 was used in Western Blotting to show that phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] lipids are enriched at the podosome and stably recruit WASP rather than the WASP-5KE mutant.</div> <div itemprodp="datePublished">Mon Jun 08 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32576662"> <div itemprop="name">Osmotic gradients induce stable dome morphogenesis on extracellular matrix.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Ishida-Ishihara S,Akiyama M,Furusawa K,Naguro I,Ryuno H,Sushida T,Ishihara S,Haga H</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that osmotic gradients induce dome morphogenesis via both enhanced water transport activity and subsequent ECM swelling.</div> <div itemprodp="datePublished">Mon Jul 27 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31571292"> <div itemprop="name">The role of polo-like kinase 3 in the response of BRAF-mutant cells to targeted anticancer therapies.</div> </a> <div itemprop="about">Molecular carcinogenesis</div> <div itemprop="author">Babagana M,Kichina JV,Slabodkin H,Johnson S,Maslov A,Brown L,Attwood K,Nikiforov MA,Kandel ES</div> <div itemprop="description">AM4300 was used in Western Blotting to study the underlying resistance mechanisms of BRAF inhibitors.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31813995"> <div itemprop="name">Bim contributes to the progression of Huntington's disease-associated phenotypes.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Roberts SL,Evans T,Yang Y,Fu Y,Button RW,Sipthorpe RJ,Cowan K,Valionyte E,Anichtchik O,Li H,Lu B,Luo S</div> <div itemprop="description">AM4300 was used in Western Blot to investigate if Bim could contribute to the progression of Huntington's disease.</div> <div itemprodp="datePublished">Wed Jan 15 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31625572"> <div itemprop="name">AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Conduit SE,Davies EM,Ooms LM,Gurung R,McGrath MJ,Hakim S,Cottle DL,Smyth IM,Dyson JM,Mitchell CA</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate AKT and mTORC1 hyperactivation in two representative murine PKD models (renal epithelial-specific Inpp5e knockout and collecting duct-specific Pkd1 deletion) and identify a downstream signaling network that contributes to DNA damage accumulation.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32460314"> <div itemprop="name">Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Ross BX,Choi J,Yao J,Hager HM,Abcouwer SF,Zacks DN</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the relationship between HMGB1 and PR survival after RD.</div> <div itemprodp="datePublished">Mon May 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32176847"> <div itemprop="name">A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.</div> </a> <div itemprop="about">ACS chemical biology</div> <div itemprop="author">Hanke T,Wong JF,Berger BT,Abdi I,Berger LM,Tesch R,Tredup C,Bullock AN,Müller S,Knapp S</div> <div itemprop="description">AM4300 was used in Western Blot to report the characterisation of the 2-oxo-imidazopyridine, TP-008, a potent chemical probe with dual activity for ALK4 and ALK5 as well as the development of a matching negative control compound.</div> <div itemprodp="datePublished">Fri Apr 17 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32716698"> <div itemprop="name">miR-125 family regulates XIRP1 and FIH in response to myocardial infarction.</div> </a> <div itemprop="about">Physiological genomics</div> <div itemprop="author">Williams AL,Khadka VS,Anagaran MCT,Lee K,Avelar A,Deng Y,Shohet RV</div> <div itemprop="description">AM4300 was used in Western Blot to characterize miRNA expression in the mouse heart after coronary artery ligation and identify novel mRNA targets altered during the initial response to ischemic stress.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32356572"> <div itemprop="name">Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.</div> </a> <div itemprop="about">The Prostate</div> <div itemprop="author">Popovics P,Awadallah WN,Kohrt SE,Case TC,Miller NL,Ricke EA,Huang W,Ramirez-Solano M,Liu Q,Vezina CM,Matusik RJ,Ricke WA,Grabowska MM</div> <div itemprop="description">AM4300 was used in Western Blotting to test whether prostate epithelial and stromal cells secrete OPN in response to proinflammatory stimuli and identified downstream targets of OPN in prostate stromal cells.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32692871"> <div itemprop="name">Increased nuclear factor I/B expression in prostate cancer correlates with AR expression.</div> </a> <div itemprop="about">The Prostate</div> <div itemprop="author">Nanda JS,Awadallah WN,Kohrt SE,Popovics P,Cates JMM,Mirosevich J,Clark PE,Giannico GA,Grabowska MM</div> <div itemprop="description">AM4300 was used in Western Blot to describe the expression pattern of nuclear factor I/B in primary and castration-resistant prostate cancer and its correlation with androgen receptor.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32565870"> <div itemprop="name">Inhibitory Activity of <i>Boesenbergia rotunda</i> (L.) Mansf. Rhizome towards the Expression of Akt and NF-KappaB p65 in Acetic Acid-Induced Wistar Rats.</div> </a> <div itemprop="about">Evidence-based complementary and alternative medicine : eCAM</div> <div itemprop="author">Rosdianto AM,Puspitasari IM,Lesmana R,Levita J</div> <div itemprop="description">AM4300 was used in Western Blot to conclude that BREE could inhibit the expression of Akt and NF-kappaB p65 in the stomach and intestine of acetic acid-induced Wistar rats.</div> <div itemprodp="datePublished">Fri Apr 15 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32414768"> <div itemprop="name">Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Morita M,Kajiye M,Sakurai C,Kubo S,Takahashi M,Kinoshita D,Hori N,Hatsuzawa K</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that MORN2, whose expression is downregulated via proteasomal digestion, is a limiting factor for LAP, and that membrane trafficking by SNARE proteins is involved in MORN2-mediated LAP.</div> <div itemprodp="datePublished">Tue Jun 23 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32065701"> <div itemprop="name">Human THO maintains the stability of repetitive DNA.</div> </a> <div itemprop="about">Genes to cells : devoted to molecular & cellular mechanisms</div> <div itemprop="author">Katahira J,Senokuchi K,Hieda M</div> <div itemprop="description">AM4300 was used in Western Blotting to analyse the genome-wide distribution of human THOC7, a component of human THO, by chromatin immunoprecipitation sequencing.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32206098"> <div itemprop="name">Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Sethuraman SN,Singh MP,Patil G,Li S,Fiering S,Hoopes PJ,Guha C,Malayer J,Ranjan A</div> <div itemprop="description">AM4300 was used in Western Blotting to report a novel calreticulin-nanoparticle that enhances ICD and synergizes with focused ultrasound to achieve local and systemic antitumor effects.</div> <div itemprodp="datePublished">Tue Apr 27 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32395654"> <div itemprop="name">Different training intensities induced autophagy and histopathology appearances potentially associated with lipid metabolism in wistar rat liver.</div> </a> <div itemprop="about">Heliyon</div> <div itemprop="author">Gunadi JW,Tarawan VM,Daniel Ray HR,Wahyudianingsih R,Lucretia T,Tanuwijaya F,Lesmana R,Supratman U,Setiawan I</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the potential linking role of autophagy-related gene expressions and protein levels with histopathology changes in Wistar rat livers after treadmill training under different intensities.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32581219"> <div itemprop="name">Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Santos JC,Boucher D,Schneider LK,Demarco B,Dilucca M,Shkarina K,Heilig R,Chen KW,Lim RYH,Broz P</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that human GBP1 acts as a cytosolic LPS sensor, assembling a platform that promotes caspase-4 recruitment and activation, the first step in non-canonical inflammasome signaling.</div> <div itemprodp="datePublished">Wed Jun 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33001025"> <div itemprop="name">Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Zhang H,Zhang Y,Zhou X,Wright S,Hyle J,Zhao L,An J,Zhao X,Shao Y,Xu B,Lee HM,Chen T,Zhou Y,Chen X,Lu R,Li C</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate HOXA9 regulation using cell lines.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33254027"> <div itemprop="name">Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43<sub>266-283</sub>.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Pelaz SG,Jaraíz-Rodríguez M,Álvarez-Vázquez A,Talaverón R,García-Vicente L,Flores-Hernández R,Gómez de Cedrón M,Tabernero M,Ramírez de Molina A,Lillo C,Medina JM,Tabernero A</div> <div itemprop="description">AM4300 was used in Western Blotting to explore the inhibition of GSCs to investigate its possible use in treatments.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32544094"> <div itemprop="name">Wnt/β-catenin-activated Ewing sarcoma cells promote the angiogenic switch.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Hawkins AG,Pedersen EA,Treichel S,Temprine K,Sperring C,Read JA,Magnuson B,Chugh R,Lawlor ER</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that Wnt/β-catenin-active tumor cells can contribute to Ewing sarcoma progression by promoting angiogenesis in the local TME.</div> <div itemprodp="datePublished">Thu Jul 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32106432"> <div itemprop="name">Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Maggisano V,Bulotta S,Celano M,Maiuolo J,Lepore SM,Abballe L,Iannone M,Russo D</div> <div itemprop="description">AM4300 was used in Western Blot to analyze the effects of methylmercury (MeHg) on immortalized, non-tumorigenic ‘normal’ thyroid cells Nthy-ori-3-1 and the molecular changes occurring after exposure to MeHg.</div> <div itemprodp="datePublished">Tue Feb 25 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32937135"> <div itemprop="name">The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Wirianto M,Yang J,Kim E,Gao S,Paudel KR,Choi JM,Choe J,Gloston GF,Ademoji P,Parakramaweera R,Jin J,Esser KA,Jung SY,Geng YJ,Lee HK,Chen Z,Yoo SH</div> <div itemprop="description">AM4300 was used in Western Blot to highlight a circadian regulatory pathway where a GSK-3β-FBXL21 functional axis controls TCAP degradation via SCF complex formation and regulates skeletal muscle function.</div> <div itemprodp="datePublished">Tue Sep 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31313842"> <div itemprop="name">A loop involving NRF2, miR-29b-1-5p and AKT, regulates cell fate of MDA-MB-231 triple-negative breast cancer cells.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">De Blasio A,Di Fiore R,Pratelli G,Drago-Ferrante R,Saliba C,Baldacchino S,Grech G,Scerri C,Vento R,Tesoriere G</div> <div itemprop="description">AM4300 was used in Western Blotting to uncover a novel NRF2/miR-29b-1-5p/AKT regulatory loop that can regulate the fate (life/death) of MDA-MB-231 cells and suggests this loop as therapeutic target for TNBC.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32218859"> <div itemprop="name">Potential synergistic effects of sorafenib and CP-31398 for treating anaplastic thyroid cancer with p53 mutations.</div> </a> <div itemprop="about">Oncology letters</div> <div itemprop="author">Wu JT,Lin CL,Huang CJ,Cheng YC,Chien CC,Sung YC</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate a potential clinical application of CP-31398 for patients with ATC harboring p53 abnormalities, since these individuals generally respond poorly to sorafenib alone.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32205379"> <div itemprop="name">Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD.</div> </a> <div itemprop="about">eNeuro</div> <div itemprop="author">Cheng W,Siedlecki-Wullich D,Català-Solsona J,Fábregas C,Fadó R,Casals N,Solé M,Unzeta M,Saura CA,Rodríguez-Alvarez J,Miñano-Molina AJ</div> <div itemprop="description">AM4300 was used in Western Blotting to show synaptic AMPAR endocytosis is influenced by proteasome degradation of A-kinase anchoring protein AKAP150.</div> <div itemprodp="datePublished">Fri Jun 18 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33207719"> <div itemprop="name">Phosphorylation of Ykt6 SNARE Domain Regulates Its Membrane Recruitment and Activity.</div> </a> <div itemprop="about">Biomolecules</div> <div itemprop="author">Karuna M P,Witte L,Linnemannstoens K,Choezom D,Danieli-Mackay A,Honemann-Capito M,Gross JC</div> <div itemprop="description">AM4300 was used in Western Blotting to show phosphorylation of SNARE protein Ykt6 leads induces a conformational change from an auto-inhibited state to an active state.</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33454014"> <div itemprop="name">Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Mears HV,Sweeney TR</div> <div itemprop="description">AM4300 was used in Western Blotting to find that Ifit1b preferentially binds to cap1-RNA, whereas binding is much weaker to cap0- and cap2-RNA.</div> <div itemprodp="datePublished">Fri Dec 18 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32523982"> <div itemprop="name">A transcriptional roadmap for 2C-like-to-pluripotent state transition.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Fu X,Djekidel MN,Zhang Y</div> <div itemprop="description">AM4300 was used in Western Blotting to analyze the transcriptional dynamics from the 2C-like state to pluripotent ESCs and identified an intermediate state.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32867961"> <div itemprop="name">Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line.</div> </a> <div itemprop="about">Poultry science</div> <div itemprop="author">Hong Y,Lee J,Vu TH,Lee S,Lillehoj HS,Hong YH</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken macrophage cell line.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33238452"> <div itemprop="name">Connexin43 Region 266-283, via Src Inhibition, Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Talaverón R,Matarredona ER,Herrera A,Medina JM,Tabernero A</div> <div itemprop="description">AM4300 was used in Western Blotting to show Src protein inhibition may contribute to the role of Cx43 in neural progenitor cells.</div> <div itemprodp="datePublished">Mon Nov 23 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32329910"> <div itemprop="name">Thrombomodulin Functional Domains Support Osteoblast Differentiation and Bone Healing in Diabetes in Mice.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Chen CH,Lai CH,Hong YK,Lu JM,Lin SY,Lee TC,Chang LY,Ho ML,Conway EM,Wu HL,Cheng TL</div> <div itemprop="description">AM4300 was used in Western Blotting to show that osteoblast TM participates in bone healing, and recombinant TMD2/3 holds promise as a novel therapy for diabetic bone defect healing.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32920522"> <div itemprop="name">Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.</div> </a> <div itemprop="about">Cell calcium</div> <div itemprop="author">Romero-García T,Landa-Galvan HV,Pavón N,Mercado-Morales M,Valdivia HH,Rueda A</div> <div itemprop="description">AM4300 was used in Western Blotting to conclude that CaMKII autonomous activation in cardiomyocytes of MetS rats with central obesity significantly contributes to abnormal diastolic Ca2+ leak, increasing the propensity for β-adrenergic receptor-driven lethal arrhythmias.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32429320"> <div itemprop="name">Rigosertib-Activated JNK1/2 Eliminate Tumor Cells through p66Shc Activation.</div> </a> <div itemprop="about">Biology</div> <div itemprop="author">Günther JK,Nikolajevic A,Ebner S,Troppmair J,Khalid S</div> <div itemprop="description">AM4300 was used in Western Blotting to provide evidence that establishes p66Shc, an oxidoreductase, as a JNK1/2 effector downstream of Rigosertib-induced ROS production, DNA damage, and cell death.</div> <div itemprodp="datePublished">Fri May 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32013265"> <div itemprop="name">miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Streleckiene G,Inciuraite R,Juzenas S,Salteniene V,Steponaitiene R,Gyvyte U,Kiudelis G,Leja M,Ruzgys P,Satkauskas S,Kupcinskiene E,Franke S,Thon C,Link A,Kupcinskas J,Skieceviciene J</div> <div itemprop="description">AM4300 was used in Western Blot to study the expression of miR-20b and miR-451a are deregulated in vitro and in vivo and have a tumor suppressive role in GC through regulation of the PI3K/AKT/mTOR signaling pathway.</div> <div itemprodp="datePublished">Wed Jan 29 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32584258"> <div itemprop="name">Alternative polyadenylation mediates genetic regulation of gene expression.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Mittleman BE,Pott S,Warland S,Zeng T,Mu Z,Kaur M,Gilad Y,Li Y</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that alternative polyadenylation (APA) links genetic variation to variation in gene expression, protein expression, and disease risk, and reveals uncharted modes of genetic regulation.</div> <div itemprodp="datePublished">Thu Jun 25 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32937031"> <div itemprop="name">Dissecting the transactivation domain (tAD) of the transcription factor c-Myb to assess recent models of tAD function.</div> </a> <div itemprop="about">FEBS open bio</div> <div itemprop="author">Naes G,Storesund JO,Udayakumar PD,Ledsaak M,Gabrielsen OS</div> <div itemprop="description">AM4300 was used in Western Blotting to revisit the tAD of the haematopoietic transcription factor c-Myb by performing a mutational analysis to see how these new models fit and potentially explain the tAD behaviour of this master regulator.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32887693"> <div itemprop="name">The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models.</div> </a> <div itemprop="about">eNeuro</div> <div itemprop="author">Verma DK,Ghosh A,Ruggiero L,Cartier E,Janezic E,Williams D,Jung EG,Moore M,Seo JB,Kim YH</div> <div itemprop="description">AM4300 was used in Western Blotting to support that SUMOylation can be a regulatory target to protect dopaminergic neurons from oxidative stress and protein aggregation, with the implication that high levels of SUMOylation in dopaminergic neurons can prevent the pathologic progression of Parkinson's disease (PD).</div> <div itemprodp="datePublished">Fri Jun 18 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32072069"> <div itemprop="name">Selective hyperactivation of JNK2 in an animal model of temporal lobe epilepsy.</div> </a> <div itemprop="about">IBRO reports</div> <div itemprop="author">Parikh AN,Concepcion FA,Khan MN,Boehm RD,Poolos OC,Dhami A,Poolos NP</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the timeline of JNK activation during epileptogenesis, and to identify the JNK isoform(s) that undergo hyperactivation in the chronic epilepsy stage.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32647191"> <div itemprop="name">Sex-specific features of spine densities in the hippocampus.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Brandt N,Löffler T,Fester L,Rune GM</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that hippocampal neurons are differentiated in a sex-dependent manner, this differentiation being likely to develop during the perinatal period.</div> <div itemprodp="datePublished">Thu Jul 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32997983"> <div itemprop="name">Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Selyutina A,Persaud M,Lee K,KewalRamani V,Diaz-Griffero F</div> <div itemprop="description">AM4300 was used in Western Blotting to explore the importance of the importance of the nuclear capsid for HIV-1 infection.</div> <div itemprodp="datePublished">Tue Sep 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32813698"> <div itemprop="name">Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Farley-Barnes KI,Deniz E,Overton MM,Khokha MK,Baserga SJ</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal another connection between craniofacial development and making ribosomes through the protein Paired Box 9 (PAX9).</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32748870"> <div itemprop="name">Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Vitali E,Boemi I,Tarantola G,Piccini S,Zerbi A,Veronesi G,Baldelli R,Mazziotti G,Smiroldo V,Lavezzi E,Spada A,Mantovani G,Lania AG</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the effects of the metformin and everolimus combination on NET cell proliferation, apoptosis, colony formation, cell viability, NET spheroids growth and the involvement of the Akt and mTOR pathways, and also developed everolimus-resistant NET cells to further study this combination.</div> <div itemprodp="datePublished">Sun Aug 02 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32579942"> <div itemprop="name">Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Di Nardo A,Lenoël I,Winden KD,Rühmkorf A,Modi ME,Barrett L,Ercan-Herbst E,Venugopal P,Behne R,Lopes CAM,Kleiman RJ,Bettencourt-Dias M,Sahin M</div> <div itemprop="description">AM4300 was used in Western Blotting to examine whether neuronal cilia are affected in TSC.</div> <div itemprodp="datePublished">Tue Jun 23 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32595640"> <div itemprop="name">Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished T<sub>H</sub>17 but Enhanced T<sub>reg</sub> Differentiation.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Liang J,Ziegler JD,Jahraus B,Orlik C,Blatnik R,Blank N,Niesler B,Wabnitz G,Ruppert T,Hübner K,Balta E,Samstag Y</div> <div itemprop="description">AM4300 was used in Western Blot to investigate the effects of piperlongumine on the survival and function of primary human peripheral blood T cells.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31995605"> <div itemprop="name">Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Landa-Galvan HV,Rios-Castro E,Romero-Garcia T,Rueda A,Olivares-Reyes JA</div> <div itemprop="description">AM4300 was used in Western Blotting to report in cardiomyocytes of MetS rats, diminished insulin-induced glucose uptake and Akt activation, evaluated by its impaired mobilization towards the plasma membrane and phosphorylation, and reflected in a re-distribution of its interacting proteins, assessed by label-free mass spectrometry.</div> <div itemprodp="datePublished">Tue Apr 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32601609"> <div itemprop="name">Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.</div> </a> <div itemprop="about">Nature metabolism</div> <div itemprop="author">Brett JO,Arjona M,Ikeda M,Quarta M,de Morrée A,Egner IM,Perandini LA,Ishak HD,Goshayeshi A,Benjamin DI,Both P,Rodríguez-Mateo C,Betley MJ,Wyss-Coray T,Rando TA</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the effect of exercise on aged stem cell function in the context of tissue regeneration in old mice.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32651364"> <div itemprop="name">A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Xie Z,Janczyk PŁ,Zhang Y,Liu A,Shi X,Singh S,Facemire L,Kubow K,Li Z,Jia Y,Schafer D,Mandell JW,Abounader R,Li H</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal a connection between cytoskeleton and FOXM1, and establish a signalling axis of AVIL/FOXM1/LIN28B/let-7.</div> <div itemprodp="datePublished">Fri Jul 10 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32391791"> <div itemprop="name">Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Butt BG,Owen DJ,Jeffries CM,Ivanova L,Hill CH,Houghton JW,Ahmed MF,Antrobus R,Svergun DI,Welch JJ,Crump CM,Graham SC</div> <div itemprop="description">AM4300 was used in Western Blotting to provide a structural framework for understanding the role of the conserved pUL7:pUL51 complex in herpesvirus assembly.</div> <div itemprodp="datePublished">Mon May 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32154650"> <div itemprop="name">Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress.</div> </a> <div itemprop="about">Brain and behavior</div> <div itemprop="author">Palumbo MC,Dominguez S,Dong H</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the behavioral and biochemical responses of the HPA axis in C57BL/6 mice.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32023459"> <div itemprop="name">Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Dubreuil MM,Morgens DW,Okumoto K,Honsho M,Contrepois K,Lee-McMullen B,Traber GM,Sood RS,Dixon SJ,Snyder MP,Fujiki Y,Bassik MC</div> <div itemprop="description">AM4300 was used in Western Blotting to provide insights into the roles of peroxisomal matrix import and the pentose phosphate pathway in redox biology.</div> <div itemprodp="datePublished">Tue Feb 04 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32636760"> <div itemprop="name">Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in <i>mdx</i> Mice.</div> </a> <div itemprop="about">Frontiers in physiology</div> <div itemprop="author">Moore TM,Lin AJ,Strumwasser AR,Cory K,Whitney K,Ho T,Ho T,Lee JL,Rucker DH,Nguyen CQ,Yackly A,Mahata SK,Wanagat J,Stiles L,Turcotte LP,Crosbie RH,Zhou Z</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate a mitochondrial and metabolic phenotype in both male and female mdx mice prior to the onset of muscle fiber abnormalities, potentially suggesting an early mitochondrial role in the etiology of this disease.</div> <div itemprodp="datePublished">Wed May 03 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32471994"> <div itemprop="name">TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca<sup>2</sup>.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Woolums BM,McCray BA,Sung H,Tabuchi M,Sullivan JM,Ruppell KT,Yang Y,Mamah C,Aisenberg WH,Saavedra-Rivera PC,Larin BS,Lau AR,Robinson DN,Xiang Y,Wu MN,Sumner CJ,Lloyd TE</div> <div itemprop="description">AM4300 was used in Western Blotting to highlight an integral role for CaMKII in neuronal TRPV4-associated Ca2+ responses, the importance of tightly regulated Ca2+ dynamics for mitochondrial axonal transport, and the therapeutic promise of TRPV4 antagonists for patients with TRPV4-related neurodegenerative diseases.</div> <div itemprodp="datePublished">Fri May 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33326798"> <div itemprop="name">An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Tada T,Fan C,Chen JS,Kaur R,Stapleford KA,Gristick H,Dcosta BM,Wilen CB,Nimigean CM,Landau NR</div> <div itemprop="description">AM4300 was used in Western Blot to report an improved soluble angiotensin-converting enzyme 2 (ACE2), termed a "microbody," in which the ACE2 ectodomain is fused to Fc domain 3 of the immunoglobulin (Ig) heavy chain.</div> <div itemprodp="datePublished">Tue Dec 22 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32784484"> <div itemprop="name">The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties.</div> </a> <div itemprop="about">Viruses</div> <div itemprop="author">Su Y,Stahelin RV</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that the presence of the EBOV major matrix protein VP40 did not promote VP24 membrane association in vitro or in cells.</div> <div itemprodp="datePublished">Sat Aug 08 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32187548"> <div itemprop="name">Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Selyutina A,Persaud M,Simons LM,Bulnes-Ramos A,Buffone C,Martinez-Lopez A,Scoca V,Di Nunzio F,Hiatt J,Marson A,Krogan NJ,Hultquist JF,Diaz-Griffero F</div> <div itemprop="description">AM4300 was used in Western Blotting to show that inhibition of HIV-1 infection caused by disrupting CypA-capsid interactions is dependent on human tripartite motif 5α (TRIM5αhu), showing that TRIM5αhu restricts HIV-1 in CD4+ T cells.</div> <div itemprodp="datePublished">Tue Mar 17 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33361744"> <div itemprop="name">Low Dose of β-Carotene Regulates Inflammation, Reduces Caspase Signaling, and Correlates with Autophagy Activation in Cardiomyoblast Cell Lines.</div> </a> <div itemprop="about">Medical science monitor basic research</div> <div itemprop="author">Lesmana R,Felia Yusuf I,Goenawan H,Achadiyani A,Khairani AF,Nur Fatimah S,Supratman U</div> <div itemprop="description">AM4300 was used in Western Blotting to show that specific low-dose BC is effective and might improve cell viability by stimulating autophagy, inhibiting proinflammatory factors, and suppressing apoptosis.</div> <div itemprodp="datePublished">Mon Dec 28 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33027661"> <div itemprop="name">Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Soh TK,Davies CTR,Muenzner J,Hunter LM,Barrow HG,Connor V,Bouton CR,Smith C,Emmott E,Antrobus R,Graham SC,Weekes MP,Crump CM</div> <div itemprop="description">AM4300 was used in Western Blot to provide significant resources for future investigation of HSV-host interactions and highlights an efficient mechanism whereby a single virus protein targets a cellular trafficking factor to modify the surface of infected cells.</div> <div itemprodp="datePublished">Tue Oct 06 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32570938"> <div itemprop="name">Rab27a Contributes to the Processing of Inflammatory Pain in Mice.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Gross T,Wack G,Syhr KMJ,Tolmachova T,Seabra MC,Geisslinger G,Niederberger E,Schmidtko A,Kallenborn-Gerhardt W</div> <div itemprop="description">AM4300 was used in Western Blotting to uncover a previously unrecognized function of Rab27a in the processing of persistent inflammatory pain in mice.</div> <div itemprodp="datePublished">Thu Jun 18 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33244044"> <div itemprop="name">The absence of (TCAGGG)<sub>n</sub> repeats in some telomeres, combined with variable responses to NR2F2 depletion, suggest that this nuclear receptor plays an indirect role in the alternative lengthening of telomeres.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Alhendi ASN,Royle NJ</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that NR2F2 does not play a direct role in ALT and we speculate about an alternative role for this NR in a DNA damage response at telomeres.</div> <div itemprodp="datePublished">Thu Nov 26 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33082525"> <div itemprop="name">A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Watanabe M,Saeki Y,Takahashi H,Ohtake F,Yoshida Y,Kasuga Y,Kondo T,Yaguchi H,Suzuki M,Ishida H,Tanaka K,Hatakeyama S</div> <div itemprop="description">AM4300 was used in Western Blotting to develop an E3 ligase substrate-trapping technique that can identify substrates of E3 ligases.</div> <div itemprodp="datePublished">Tue Oct 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32995353"> <div itemprop="name">Systemic Delivery of AAV-<i>Fdxr</i> Mitigates the Phenotypes of Mitochondrial Disorders in <i>Fdxr</i> Mutant Mice.</div> </a> <div itemprop="about">Molecular therapy. Methods & clinical development</div> <div itemprop="author">Yang L,Slone J,Zou W,Queme LF,Jankowski MP,Yin F,Huang T</div> <div itemprop="description">AM4300 was used in Western Blotting to provides substantial support for the translation of AAV-based Fdxr gene therapy into clinical applications.</div> <div itemprodp="datePublished">Fri Sep 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32965214"> <div itemprop="name">Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Shaaya M,Fauser J,Zhurikhina A,Conage-Pough JE,Huyot V,Brennan M,Flower CT,Matsche J,Khan S,Natarajan V,Rehman J,Kota P,White FM,Tsygankov D,Karginov AV</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate efficient regulation of the kinase and identify temporally distinct signaling responses ranging from seconds to minutes.</div> <div itemprodp="datePublished">Wed Sep 23 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31956438"> <div itemprop="name">Gut butyrate-producing organisms correlate to Placenta Specific 8 protein: Importance to colorectal cancer progression.</div> </a> <div itemprop="about">Journal of advanced research</div> <div itemprop="author">Huang CC,Shen MH,Chen SK,Yang SH,Liu CY,Guo JW,Chang KW,Huang CJ</div> <div itemprop="description">AM4300 was used in Western Blotting to clarify the roles of PLAC8 in colorectal cancer tumorigenesis, invasion, and migration.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33312403"> <div itemprop="name">AlCl<sub>3</sub> exposure regulates neuronal development by modulating DNA modification.</div> </a> <div itemprop="about">World journal of stem cells</div> <div itemprop="author">Cheng XJ,Guan FL,Li Q,Dai G,Li HF,Li XK</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effects of aluminum on epigenetic modification in neural stem cells and neurons.</div> <div itemprodp="datePublished">Thu Nov 26 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32708220"> <div itemprop="name">The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Gyvyte U,Lukosevicius R,Inciuraite R,Streleckiene G,Gudoityte G,Bekampyte J,Valentini S,Salteniene V,Ruzgys P,Satkauskas S,Zviniene K,Kupcinskas J,Skieceviciene J</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the role of two miRNAs strongly downregulated in GIST-miR-375-3p and miR-200b-3p-in the pathogenesis of GIST.</div> <div itemprodp="datePublished">Tue Jul 21 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31964716"> <div itemprop="name">A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Chan TO,Armen RS,Yadav S,Shah S,Zhang J,Tiegs BC,Keny N,Blumhof B,Deshpande DA,Rodeck U,Penn RB</div> <div itemprop="description">AM4300 was used in Western Blotting to establish that three allosteric sites located at the PKAc N and C termini coordinately regulate the phosphatase sensitivity of this enzyme.</div> <div itemprodp="datePublished">Fri Mar 06 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33020520"> <div itemprop="name">Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Breuer M,Berger H,Borchers A</div> <div itemprop="description">AM4300 was used in Western Blotting to find that loss-of-function of Xenopus Cav1 results in a striking swimming defect characterized by paralysis of the morphants.</div> <div itemprodp="datePublished">Mon Oct 05 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32091157"> <div itemprop="name">Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.</div> </a> <div itemprop="about">Cell biology international</div> <div itemprop="author">Song Y,Gao F,Peng Y,Yang X</div> <div itemprop="description">AM4300 was used in Western Blotting to find that long non-coding RNA dopamine β hydroxylase antisense RNA 1 is upregulated in DLBC tissues and cells, and the DBH-AS1/BUD13/FN1 axis regulates disease progression.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31885878"> <div itemprop="name">The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts.</div> </a> <div itemprop="about">Signal transduction and targeted therapy</div> <div itemprop="author">Liu T,Zhou L,Yang K,Iwasawa K,Kadekaro AL,Takebe T,Andl T,Zhang Y</div> <div itemprop="description">AM4300 was used in Western Blotting to report that β-catenin is indispensable for the activation of primary human stromal fibroblasts and the mediation of fibroblast-melanoma cell interactions.</div> <div itemprodp="datePublished">Fri Jan 29 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31540829"> <div itemprop="name">Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Jeng EE,Bhadkamkar V,Ibe NU,Gause H,Jiang L,Chan J,Jian R,Jimenez-Morales D,Stevenson E,Krogan NJ,Swaney DL,Snyder MP,Mukherjee S,Bassik MC</div> <div itemprop="description">AM4300 was used in Western Blotting to characterize C1orf43 and KIAA1109 as regulators of phagocytosis and show that RAB10 and its chaperone RABIF are required for optimal L. pneumophila replication and ER recruitment to the LCV.</div> <div itemprodp="datePublished">Wed Oct 09 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31209294"> <div itemprop="name">Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Fu X,Wu X,Djekidel MN,Zhang Y</div> <div itemprop="description">AM4300 was used in Western Blotting to show the totipotent state transition in mouse embryonic stem cells is impeded by Myc-mediated downregulation of pluripotent genes and Dnmt-1-mediated prevention of 2-cell-embryo-specific gene activation.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30686764"> <div itemprop="name">Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">van der Kant R,Langness VF,Herrera CM,Williams DA,Fong LK,Leestemaker Y,Steenvoorden E,Rynearson KD,Brouwers JF,Helms JB,Ovaa H,Giera M,Wagner SL,Bang AG,Goldstein LSB</div> <div itemprop="description">AM4300 was used in Western Blotting to perform a phenotypic screen for pTau accumulation in Alzheimer's disease-patient iPSC-derived neurons and identify cholesteryl esters as upstream regulators of Tau early during AD development.</div> <div itemprodp="datePublished">Thu Mar 07 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30830875"> <div itemprop="name">Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Weng T,Ko J,Masamha CP,Xia Z,Xiang Y,Chen NY,Molina JG,Collum S,Mertens TC,Luo F,Philip K,Davies J,Huang J,Wilson C,Thandavarayan RA,Bruckner BA,Jyothula SS,Volcik KA,Li L,Han L,Li W,Assassi S,Karmouty-Quintana H,Wagner EJ,Blackburn MR</div> <div itemprop="description">AM4300 was used in Western Blotting to study the downregulation of CFIm25 in the lungs of patients with idiopathic pulmonary fibrosis and mice with pulmonary fibrosis.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31101498"> <div itemprop="name">Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling.</div> </a> <div itemprop="about">Molecular cell</div> <div itemprop="author">Lun XK,Szklarczyk D,Gábor A,Dobberstein N,Zanotelli VRT,Saez-Rodriguez J,von Mering C,Bodenmiller B</div> <div itemprop="description">AM4300 was used in Mass cytometry to reveal a drug-resistant mechanism through which overexpression of tyrosine kinases, including SRC, FES, YES1, and BLK, induced MEK-independent ERK activation in melanoma A375 cells.</div> <div itemprodp="datePublished">Thu Jun 06 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30496473"> <div itemprop="name">Developmental Xist induction is mediated by enhanced splicing.</div> </a> <div itemprop="about">Nucleic acids research</div> <div itemprop="author">Stork C,Li Z,Lin L,Zheng S</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of enhanced splicing in regulating developmental Xist induction.</div> <div itemprodp="datePublished">Wed Feb 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31127282"> <div itemprop="name">Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping.</div> </a> <div itemprop="about">Nucleic acids research</div> <div itemprop="author">Hyle J,Zhang Y,Wright S,Xu B,Shao Y,Easton J,Tian L,Feng R,Xu P,Li C</div> <div itemprop="description">AM4300 was used in Western Blotting to integrate the miniAID-mClover3 cassette to the endogenous CTCF locus in a human pediatric B-ALL cell line, SEM, and an immortal erythroid precursor cell line, HUDEP-2, to allow for acute depletion of CTCF protein by the auxin-inducible degron system.</div> <div itemprodp="datePublished">Fri Jul 26 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30886048"> <div itemprop="name">A protein quality control pathway regulated by linear ubiquitination.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">van Well EM,Bader V,Patra M,Sánchez-Vicente A,Meschede J,Furthmann N,Schnack C,Blusch A,Longworth J,Petrasch-Parwez E,Mori K,Arzberger T,Trümbach D,Angersbach L,Showkat C,Sehr DA,Berlemann LA,Goldmann P,Clement AM,Behl C,Woerner AC,Saft C,Wurst W,Haass C,Ellrichmann G,Gold R,Dittmar G,Hipp MS,Hartl FU,Tatzelt J,Winklhofer KF</div> <div itemprop="description">AM4300 was used in Western Blotting to show the linear ubiquitin chain assembly complex modifies disease-associated protein aggregates.</div> <div itemprodp="datePublished">Thu May 02 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31368601"> <div itemprop="name">ERp18 regulates activation of ATF6α during unfolded protein response.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Oka OB,van Lith M,Rudolf J,Tungkum W,Pringle MA,Bulleid NJ</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that ERp18 monitors ATF6α ER quality control to ensure optimal processing following trafficking to the Golgi.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30354910"> <div itemprop="name">Autophagosome immunoisolation from GFP-LC3B mouse tissue.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Yao J,Qiu Y,Jia L,Zacks DN</div> <div itemprop="description">AM4300 was used in Western Blotting to describe a protocol for rapid and efficient enrichment of autophagosomes from various tissues of the GFP-LC3 mouse.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30914429"> <div itemprop="name">Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Revach OY,Sandler O,Samuels Y,Geiger B</div> <div itemprop="description">AM4300 was used in Western Blotting to explore the role of the tyrosine kinome in the formation of invadopodia in metastatic melanoma cells.</div> <div itemprodp="datePublished">Wed May 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30389701"> <div itemprop="name">Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Allen-Petersen BL,Risom T,Feng Z,Wang Z,Jenny ZP,Thoma MC,Pelz KR,Morton JP,Sansom OJ,Lopez CD,Sheppard B,Christensen DJ,Ohlmeyer M,Narla G,Sears RC</div> <div itemprop="description">AM4300 was used in Western Blotting to study whether kinase inhibition and phosphatase activation could reduce tumor growth by reducing oncogenic survival.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30816805"> <div itemprop="name">Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice.</div> </a> <div itemprop="about">Arteriosclerosis, thrombosis, and vascular biology</div> <div itemprop="author">Song W,Zhang CL,Gou L,He L,Gong YY,Qu D,Zhao L,Jin N,Chan TF,Wang L,Tian XY,Luo JY,Huang Y</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of transcription factor EB in the regulation of endothelial inflammation in diabetes.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30575814"> <div itemprop="name">Recurrent somatic BRAF insertion (p.V504_R506dup): a tumor marker and a potential therapeutic target in pilocytic astrocytoma.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Khater F,Langlois S,Cassart P,Roy AM,Lajoie M,Healy J,Richer C,St-Onge P,Piché N,Perreault S,Cellot S,Marzouki M,Jabado N,Sinnett D</div> <div itemprop="description">AM4300 was used in Western Blotting to emphasize the importance of BRAF alterations in PA and the need to characterize them in a given tumor as this can affect therapeutic strategies and their potential use as tumor marker in molecular diagnostics.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30447238"> <div itemprop="name">LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.</div> </a> <div itemprop="about">The Journal of investigative dermatology</div> <div itemprop="author">Sumitomo A,Siriwach R,Thumkeo D,Ito K,Nakagawa R,Tanaka N,Tanabe K,Watanabe A,Kishibe M,Ishida-Yamamoto A,Honda T,Kabashima K,Aoki J,Narumiya S</div> <div itemprop="description">AM4300 was used in Western Blotting to show a previously unsuspected role for lysophosphatidic acid and its downstream signaling in the maintenance of skin homeostasis, which may serve as a novel therapeutic target for skin barrier dysfunction.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31719041"> <div itemprop="name">Dorsal convergence of gastrula cells requires Vangl2 and an adhesion protein-dependent change in protrusive activity.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Prince DJ,Jessen JR</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the transition to PCP-dependent mesodermal cell migration to determine the types of membrane protrusions involved and their regulation by Vangl2.</div> <div itemprodp="datePublished">Mon Nov 25 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30936240"> <div itemprop="name">p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Baho E,Chattopadhyaya B,Lavertu-Jolin M,Mazziotti R,Awad PN,Chehrazi P,Groleau M,Jahannault-Talignani C,Vaucher E,Ango F,Pizzorusso T,Baroncelli L,Di Cristo G</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal a new p75NTR function in the regulation of the time course of PV cell maturation and in limiting cortical plasticity.</div> <div itemprodp="datePublished">Wed Jun 05 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31653658"> <div itemprop="name">Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice.</div> </a> <div itemprop="about">Journal of lipid research</div> <div itemprop="author">Agarwal AK,Tunison K,Mitsche MA,McDonald JG,Garg A</div> <div itemprop="description">AM4300 was used in Western Blotting to report a marked increase in adipocytes in the psoas and gluteus muscles but not in the soleus and tibialis anterior muscles in aged dysferlin(DYSF)-null (Bla/J)(Bla/J) mice compared with WT mice.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31097694"> <div itemprop="name">LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.</div> </a> <div itemprop="about">Oncogenesis</div> <div itemprop="author">Morén A,Bellomo C,Tsubakihara Y,Kardassis D,Mikulits W,Heldin CH,Moustakas A</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the role of liver X receptors during myofibroblast differentiation.</div> <div itemprodp="datePublished">Thu May 16 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31154015"> <div itemprop="name">m<sup>6</sup>A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.</div> </a> <div itemprop="about">Genomics, proteomics & bioinformatics</div> <div itemprop="author">Chen J,Zhang YC,Huang C,Shen H,Sun B,Cheng X,Zhang YJ,Yang YG,Shu Q,Yang Y,Li X</div> <div itemprop="description">AM4300 was used in Western Blotting to uncover a crosstalk between RNA and histone modifications and indicate that Mettl3-mediated m6A modification plays an important role in regulating neurogenesis and neuronal development through modulating Ezh2.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31620439"> <div itemprop="name">Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Andersohn A,Garcia MI,Fan Y,Thompson MC,Akimzhanov AM,Abdullahi A,Jeschke MG,Boehning D</div> <div itemprop="description">AM4300 was used in Western Blot to show that induction of chronic ER stress leads to the release of known and novel damage-associated molecular patterns.</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30721098"> <div itemprop="name">Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet.</div> </a> <div itemprop="about">American journal of physiology. Endocrinology and metabolism</div> <div itemprop="author">Singh AB,Kan CFK,Kraemer FB,Sobel RA,Liu J</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the acute effects of hepatic ACSL4 deficiency on lipid metabolism in adult mice fed a high-fat diet (HFD).</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30615497"> <div itemprop="name">A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">van der Veen JN,Lingrell S,McCloskey N,LeBlond ND,Galleguillos D,Zhao YY,Curtis JM,Sipione S,Fullerton MD,Vance DE,Jacobs RL</div> <div itemprop="description">AM4300 was used in Western Blotting to show that treatments to reduce the PC:PE ratio in liver may protect against the development of hepatic insulin resistance.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30204499"> <div itemprop="name">Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Kodji X,Arkless KL,Kee Z,Cleary SJ,Aubdool AA,Evans E,Caton P,Pitchford SC,Brain SD</div> <div itemprop="description">AM4300 was used in Western Blotting to study the involvement of sensory nerve mediators with a murine model of psoriasis and associated spontaneous behaviours, indicative of cutaneous discomfort.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31036697"> <div itemprop="name">Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Collum SD,Molina JG,Hanmandlu A,Bi W,Pedroza M,Mertens TCJ,Wareing N,Wei W,Wilson C,Sun W,Rajadas J,Bollyky PL,Philip KM,Ren D,Thandavarayan RA,Bruckner BA,Xia Y,Blackburn MR,Karmouty-Quintana H</div> <div itemprop="description">AM4300 was used in Western Blotting to generate pre-clinical data demonstrating the capacity of 4MU, an FDA-approved drug, to attenuate features of CPFE in an experimental model of chronic lung injury.</div> <div itemprodp="datePublished">Wed May 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31318984"> <div itemprop="name">A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome activity resulting in microcephaly, psychomotor retardation, and epilepsy.</div> </a> <div itemprop="about">Journal of neurochemistry</div> <div itemprop="author">Rodríguez C,Sánchez-Morán I,Álvarez S,Tirado P,Fernández-Mayoralas DM,Calleja-Pérez B,Almeida Á,Fernández-Jaén A</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that the loss of function of APC/C-Cdh1 caused by Cdh1 Asp187Gly mutation is a new cause of prenatal microcephaly, psychomotor retardation, and severe epilepsy.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30670910"> <div itemprop="name">Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.</div> </a> <div itemprop="about">World journal of gastroenterology</div> <div itemprop="author">Lukosiute-Urboniene A,Jasukaitiene A,Silkuniene G,Barauskas V,Gulbinas A,Dambrauskas Z</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the association of human antigen R and inhibitors of apoptosis proteins and prognosis in pancreatic cancer.</div> <div itemprodp="datePublished">Mon Jan 14 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30700940"> <div itemprop="name">Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.</div> </a> <div itemprop="about">World journal of gastroenterology</div> <div itemprop="author">Prieto P,Jaén RI,Calle D,Gómez-Serrano M,Núñez E,Fernández-Velasco M,Martín-Sanz P,Alonso S,Vázquez J,Cerdán S,Peinado MÁ,Boscá L</div> <div itemprop="description">AM4300 was used in Western Blotting to study the expression profile of cyclo-oxygenase 2 in the tumour tissue of colorectal cancer patients compared to the adjacent non-tumour area.</div> <div itemprodp="datePublished">Mon Jan 28 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31509448"> <div itemprop="name">cGMP-dependent protein kinase II determines β-catenin accumulation that is essential for uterine decidualization in mice.</div> </a> <div itemprop="about">American journal of physiology. Cell physiology</div> <div itemprop="author">Zhang Y,Yan L,Liu J,Cui S,Qiu J</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that estrogen and progesterone upregulate the expression of Prkg2 in uterine stromal cells depending on ER and PR; Prkg2 promotes phosphorylation of GSK-3β at serine-9 and inactivates it, leading to the accumulation of β-catenin and promoting the process of decidualization.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30699367"> <div itemprop="name">Effects of Neddylation and mTOR Inhibition in Acute Myelogenous Leukemia.</div> </a> <div itemprop="about">Translational oncology</div> <div itemprop="author">Guo N,Azadniv M,Coppage M,Nemer M,Mendler J,Becker M,Liesveld J</div> <div itemprop="description">AM4300 was used in Western Blotting to evaluate the effects of pevonedistat and sapanisertib as single agents or in combination on acute myeloid leukaemia cell lines.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31372790"> <div itemprop="name">PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.</div> </a> <div itemprop="about">Breast cancer research and treatment</div> <div itemprop="author">Zhang L,Bailleul J,Yazal T,Dong K,Sung D,Dao A,Gosa L,Nathanson D,Bhat K,Duhachek-Muggy S,Alli C,Dratver MB,Pajonk F,Vlashi E</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the effect of ionizing radiation (IR) on M2 isoform of pyruvate kinase(PK-M2)-mediated metabolic changes in triple negative breast cancers(TNBC) cells, and their survival.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31135968"> <div itemprop="name">A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling.</div> </a> <div itemprop="about">FEBS letters</div> <div itemprop="author">Ahmed M,Legrand C,Yagüe Relimpio A,Beretta CA,Muschko A,Wegehingel S,Müller HM,Sehr P,Will DW,Lewis JD,Nickel W</div> <div itemprop="description">AM4300 was used in Western Blot to describe a novel time-resolved FGF2 signaling assay based upon live cell imaging of neuroblastoma cells.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31452747"> <div itemprop="name">Sulforaphane-induced epigenetic regulation of Nrf2 expression by DNA methyltransferase in human Caco-2 cells.</div> </a> <div itemprop="about">Oncology letters</div> <div itemprop="author">Zhou JW,Wang M,Sun NX,Qing Y,Yin TF,Li C,Wu D</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that sulforaphane could promote demethylation of Nrf2 promotor region, inducing chemoprevention of colon cancer.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31423266"> <div itemprop="name">Stimulated upregulation of <i>HO-1</i> is associated with inadequate response of gastric and ovarian cancer cell lines to hyperthermia and cisplatin treatment.</div> </a> <div itemprop="about">Oncology letters</div> <div itemprop="author">Cesna V,Sukovas A,Jasukaitiene A,Silkuniene G,Paskauskas S,Dambrauskas Z,Gulbinas A</div> <div itemprop="description">AM4300 was used in Western Blotting to clarify the response of gastric and ovarian cancer cells to hyperthermic intraperitoneal chemotherapy, following the modulation of HO-1 expression.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31362948"> <div itemprop="name">HDAC3 and HDAC8 are required for cilia assembly and elongation.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Park SA,Yoo H,Seol JH,Rhee K</div> <div itemprop="description">AM4300 was used in Western Blotting to report on the role of histone deacetylases and show that they are required for the assembly and elongation of the primary cilia.</div> <div itemprodp="datePublished">Fri Aug 09 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30578251"> <div itemprop="name">E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Smyrek I,Mathew B,Fischer SC,Lissek SM,Becker S,Stelzer EHK</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate spheroid formation dynamics in cell lines of different metastatic potential.</div> <div itemprodp="datePublished">Thu Jan 24 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31044179"> <div itemprop="name">Glucocorticoid-Induced Autophagy Protects Osteocytes Against Oxidative Stress Through Activation of MAPK/ERK Signaling.</div> </a> <div itemprop="about">JBMR plus</div> <div itemprop="author">Kar R,Riquelme MA,Hua R,Jiang JX</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effect of glucocorticoid induced autophagy on oxidative stress in osteocytes.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30718762"> <div itemprop="name">Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Rangel L,Bernabé-Rubio M,Fernández-Barrera J,Casares-Arias J,Millán J,Alonso MA,Correas I</div> <div itemprop="description">AM4300 was used in Western Blotting to study the mechanism by which caveolin-1α regulates primary cilium length.</div> <div itemprodp="datePublished">Mon Feb 04 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31018136"> <div itemprop="name">Modeling Glycan Processing Reveals Golgi-Enzyme Homeostasis upon Trafficking Defects and Cellular Differentiation.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Fisher P,Spencer H,Thomas-Oates J,Wood AJ,Ungar D</div> <div itemprop="description">AM4300 was used in Western Blotting to develop and validate a computational model for glycan biosynthesis to probe how the biosynthetic machinery creates different glycan profiles.</div> <div itemprodp="datePublished">Tue Apr 23 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30429210"> <div itemprop="name">Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974.</div> </a> <div itemprop="about">Molecular & cellular proteomics : MCP</div> <div itemprop="author">Schiza C,Korbakis D,Jarvi K,Diamandis EP,Drabovich AP</div> <div itemprop="description">AM4300 was used in Western Blotting to identify TEX101-associated proteins through proteomic measurement of human spermatozoa homozygous for the missense variant rs35033974.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30744518"> <div itemprop="name">BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Ji C,Tang M,Zeidler C,Höhfeld J,Johnson GV</div> <div itemprop="description">AM4300 was used in Immunocytochemistry to demonstrate for the first time that BAG3 plays an important role in autophagic flux in the neurites of mature neurons (20-24 days in vitro [DIV]) through interaction with the post-synaptic cytoskeleton protein SYNPO (synaptopodin).</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31889088"> <div itemprop="name">CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Rossello X,Rodriguez-Sinovas A,Vilahur G,Crisóstomo V,Jorge I,Zaragoza C,Zamorano JL,Bermejo J,Ordoñez A,Boscá L,Vázquez J,Badimón L,Sánchez-Margallo FM,Fernández-Avilés F,Garcia-Dorado D,Ibanez B</div> <div itemprop="description">AM4300 was used in Western Blotting to evaluate experimental reproducibility before stepping into the clinical arena.</div> <div itemprodp="datePublished">Mon Dec 30 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30539787"> <div itemprop="name">Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Martin-Mateos R,De Assuncao TM,Arab JP,Jalan-Sakrikar N,Yaqoob U,Greuter T,Verma VK,Mathison AJ,Cao S,Lomberk G,Mathurin P,Urrutia R,Huebert RC,Shah VH</div> <div itemprop="description">AM4300 was used in Western Blotting to analyse the epigenetic modulators that differentially control Transforming Growth Factor-Β and platelet-derived growth factor signalling pathways.</div> <div itemprodp="datePublished">Mon Apr 29 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31030596"> <div itemprop="name">Role of Ryanodine Type 2 Receptors in Elementary Ca<sup>2+</sup> Signaling in Arteries and Vascular Adaptive Responses.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Kaßmann M,Szijártó IA,García-Prieto CF,Fan G,Schleifenbaum J,Anistan YM,Tabeling C,Shi Y,le Noble F,Witzenrath M,Huang Y,Markó L,Nelson MT,Gollasch M</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the impact of individual ryanodine receptors isoforms on adaptive vascular responses.</div> <div itemprodp="datePublished">Tue May 07 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30866939"> <div itemprop="name">GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice.</div> </a> <div itemprop="about">BMC biology</div> <div itemprop="author">Wen J,Yan H,He M,Zhang T,Mu X,Wang H,Zhang H,Xia G,Wang C</div> <div itemprop="description">AM4300 was used in Western Blotting to study the underlying mechanisms governing foetal oocyte attrition.</div> <div itemprodp="datePublished">Tue Mar 12 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30764689"> <div itemprop="name">Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Li J,Kemp BA,Howell NL,Massey J,Mińczuk K,Huang Q,Chordia MD,Roy RJ,Patrie JT,Davogustto GE,Kramer CM,Epstein FH,Carey RM,Taegtmeyer H,Keller SR,Kundu BK</div> <div itemprop="description">AM4300 was used in Western Blotting to study metabolic changes in spontaneously hypertensive rats during early hypertension development, compared with control Wistar Kyoto rats.</div> <div itemprodp="datePublished">Tue Feb 19 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31278855"> <div itemprop="name">TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death.</div> </a> <div itemprop="about">Cancer medicine</div> <div itemprop="author">Qin W,Godec A,Zhang X,Zhu C,Shao J,Tao Y,Bu X,Hirbe AC</div> <div itemprop="description">AM4300 was used in Western Blotting to illustrate the importance of TYK2 in MPNST pathogenesis and suggest that the TYK2 pathway may be a potential therapeutic target for these deadly cancers.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31332168"> <div itemprop="name">Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">McMahon KA,Wu Y,Gambin Y,Sierecki E,Tillu VA,Hall T,Martel N,Okano S,Moradi SV,Ruelcke JE,Ferguson C,Yap AS,Alexandrov K,Hill MM,Parton RG</div> <div itemprop="description">AM4300 was used in Western Blotting to identify a pro-apoptotic signaling pathway from surface caveolae to the nucleus.</div> <div itemprodp="datePublished">Mon Jul 22 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31496720"> <div itemprop="name">Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer.</div> </a> <div itemprop="about">International journal of tryptophan research : IJTR</div> <div itemprop="author">Vichaya EG,Vermeer DW,Budac D,Lee A,Grossberg A,Vermeer PD,Lee JH,Dantzer R</div> <div itemprop="description">AM4300 was used in Western Blotting to determine whether indoleamine 2,3 dioxygenase (IDO) inhibition, intended to facilitate tumor clearance in response to treatment, attenuates behavioral alterations associated with tumor growth and treatment.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31372503"> <div itemprop="name">Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.</div> </a> <div itemprop="about">Wellcome open research</div> <div itemprop="author">Mears HV,Emmott E,Chaudhry Y,Hosmillo M,Goodfellow IG,Sweeney TR</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of Ifit1 in murine macrophage like cells.</div> <div itemprodp="datePublished">Sun Jan 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31644914"> <div itemprop="name">CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Koutmani Y,Gampierakis IA,Polissidis A,Ximerakis M,Koutsoudaki PN,Polyzos A,Agrogiannis G,Karaliota S,Thomaidou D,Rubin LL,Politis PK,Karalis KP</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest a critical role of CRH in adult neurogenesis, independently of its stress-related systemic function.</div> <div itemprodp="datePublished">Tue Oct 22 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30548660"> <div itemprop="name">miR-150-504-519d inhibits the growth of human colorectal cancer cell line SW48 and downregulates c-FLIP receptor.</div> </a> <div itemprop="about">Journal of cellular biochemistry</div> <div itemprop="author">Rong G,Yang X,Wu H,Wu Y</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate upregulation of c-FLIP in CRC, which was downregulated in SW48 cells after the transfection of miR-150-504-519d, suggesting that manipulation of miR-150-504-519d expression might be a novel approach for the treatment of colorectal cancer.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30924982"> <div itemprop="name">Biallelic mutation in MYH7 and MYBPC3 leads to severe cardiomyopathy with left ventricular noncompaction phenotype.</div> </a> <div itemprop="about">Human mutation</div> <div itemprop="author">Kolokotronis K,Kühnisch J,Klopocki E,Dartsch J,Rost S,Huculak C,Mearini G,Störk S,Carrier L,Klaassen S,Gerull B</div> <div itemprop="description">AM4300 was used in Western Blotting to present three cases carrying a loss-of-function (LoF) variant in a compound heterozygous state with a missense variant in either MYH7 or MYBPC3 leading to severe cardiomyopathy with left ventricular noncompaction.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30787662"> <div itemprop="name">Alteration of Autophagy Gene Expression by Different Intensity of Exercise in Gastrocnemius and Soleus Muscles of Wistar Rats.</div> </a> <div itemprop="about">Journal of sports science & medicine</div> <div itemprop="author">Tarawan VM,Gunadi JW,Lesmana R,Goenawan H,Meilina DE,Sipayung JA,Wargasetia TL,Widowati W,Limyati Y,Supratman U</div> <div itemprop="description">AM4300 was used in Western Blotting to determine if varied intensity exercises have different impacts on autophagy gene expression in soleus and gastrocnemius muscles of wistar rats.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31320609"> <div itemprop="name">Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Qiu Y,Yao J,Jia L,Thompson DA,Zacks DN</div> <div itemprop="description">AM4300 was used in Western Blotting to support the conclusion that normalizing the A:P ratio, either by reducing the ERS-induced activation of autophagy, or by increasing proteasome activity, improves photoreceptor survival.</div> <div itemprodp="datePublished">Thu Jul 18 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31831046"> <div itemprop="name">EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.</div> </a> <div itemprop="about">Alzheimer's research & therapy</div> <div itemprop="author">Poppe L,Rué L,Timmers M,Lenaerts A,Storm A,Callaerts-Vegh Z,Courtand G,de Boer A,Smolders S,Van Damme P,Van Den Bosch L,D'Hooge R,De Strooper B,Robberecht W,Lemmens R</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate whether EphA4 ablation might preserve synapse function and ameliorate cognitive performance in the APPPS1 transgenic mouse model of AD.</div> <div itemprodp="datePublished">Thu Dec 12 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31519756"> <div itemprop="name">Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Hoffman HK,Fernandez MV,Groves NS,Freed EO,van Engelenburg SB</div> <div itemprop="description">AM4300 was used in Western Blotting to use CRISPR/Cas9-mediated knock-in to tag the critical ESCRT-I component tumor susceptibility 101 (Tsg101) with GFP at its native locus.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31665630"> <div itemprop="name">A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Bocarsly ME,da Silva E Silva D,Kolb V,Luderman KD,Shashikiran S,Rubinstein M,Sibley DR,Dobbs LK,Alvarez VA</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate a link between two vulnerability factors for alcohol abuse and offer evidence for a mechanism in which low striatal D2Rs trigger D1R hypersensitivity, ultimately leading to compulsive-like drinking.</div> <div itemprodp="datePublished">Tue Oct 29 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31004036"> <div itemprop="name">The priming factor CAPS1 regulates dense-core vesicle acidification by interacting with rabconnectin3β/WDR7 in neuroendocrine cells.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Crummy E,Mani M,Thellman JC,Martin TFJ</div> <div itemprop="description">AM4300 was used in Western Blotting to determine how CAPS1 binds to dense-core vesicles and the role of CAPS1 in the regulation of the pH of dense-core vesicles.</div> <div itemprodp="datePublished">Fri Jun 14 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30770803"> <div itemprop="name">Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Scrivo A,Codogno P,Bomont P</div> <div itemprop="description">AM4300 was used in Western Blotting to unveil the fundamental mechanisms of the control of autophagosome formation, and provide a molecular switch to fine-tune the activation of autophagy.</div> <div itemprodp="datePublished">Fri Feb 15 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30917321"> <div itemprop="name">GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Raghu D,Mobley RJ,Shendy NAM,Perry CH,Abell AN</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the biological relevance of GALNT3 in trophoblast stem cells.</div> <div itemprodp="datePublished">Tue Mar 26 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31130521"> <div itemprop="name">Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response.</div> </a> <div itemprop="about">Cell chemical biology</div> <div itemprop="author">Klomp JE,Shaaya M,Matsche J,Rebiai R,Aaron JS,Collins KB,Huyot V,Gonzalez AM,Muller WA,Chew TL,Malik AB,Karginov AV</div> <div itemprop="description">AM4300 was used in Western Blot to control tyrosine kinase SRC activation to investigate endothelial barrier enhancement via SRC required phosphorylation of VE cadherin at Y731.</div> <div itemprodp="datePublished">Thu Aug 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31114513"> <div itemprop="name">Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats.</div> </a> <div itemprop="about">Frontiers in physiology</div> <div itemprop="author">Fernández-Miranda G,Romero-Garcia T,Barrera-Lechuga TP,Mercado-Morales M,Rueda A</div> <div itemprop="description">AM4300 was used in Western Blotting to show the impaired in situ activity of RyR2 may also account for the poor overall cardiac outcome reported in MetS patients; hence, the SERCA pump and RyR2 are both attractive potential targets for future therapies.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31699992"> <div itemprop="name">Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Wang C,Scott SM,Subramanian K,Loguercio S,Zhao P,Hutt DM,Farhat NY,Porter FD,Balch WE</div> <div itemprop="description">AM4300 was used in Western Blotting to understand the impact of epigenetics on human misfolding disease.</div> <div itemprodp="datePublished">Thu Nov 07 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30988429"> <div itemprop="name">Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.</div> </a> <div itemprop="about">Nature microbiology</div> <div itemprop="author">Yamane D,Feng H,Rivera-Serrano EE,Selitsky SR,Hirai-Yuki A,Das A,McKnight KL,Misumi I,Hensley L,Lovell W,González-López O,Suzuki R,Matsuda M,Nakanishi H,Ohto-Nakanishi T,Hishiki T,Wauthier E,Oikawa T,Morita K,Reid LM,Sethupathy P,Kohara M,Whitmire JK,Lemon SM</div> <div itemprop="description">AM4300 was used in Western Blotting to map critical host pathways restricting positive-strand RNA virus replication in immortalized hepatocytes and identify a role for IRF1.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31152063"> <div itemprop="name">Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Cragle CE,MacNicol MC,Byrum SD,Hardy LL,Mackintosh SG,Richardson WA,Gray NK,Childs GV,Tackett AJ,MacNicol AM</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the molecular events that distinguish Musashi-mediated translational activation from repression.</div> <div itemprodp="datePublished">Fri Jul 12 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30766963"> <div itemprop="name">Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High-Fat Diet.</div> </a> <div itemprop="about">Hepatology communications</div> <div itemprop="author">Wan S,Kuipers F,Havinga R,Ando H,Vance DE,Jacobs RL,van der Veen JN</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate whether phosphatidylethanolamine N-methyltransferase is an important supplier of phosphatidylcholine to the canaliculus and its role in maintaining canalicular membrane integrity and bile formation following high-fat diet feeding.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30591411"> <div itemprop="name">The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.</div> </a> <div itemprop="about">Molecular metabolism</div> <div itemprop="author">Moore TM,Zhou Z,Cohn W,Norheim F,Lin AJ,Kalajian N,Strumwasser AR,Cory K,Whitney K,Ho T,Ho T,Lee JL,Rucker DH,Shirihai O,van der Bliek AM,Whitelegge JP,Seldin MM,Lusis AJ,Lee S,Drevon CA,Mahata SK,Turcotte LP,Hevener AL</div> <div itemprop="description">AM4300 was used in Western Blotting to compare the ability of Clostridioides difficile spores to germinate, produce toxin and cause tissue damage in a bioengineered 3D tissue model versus in a 2D transwell model in which human cells form a polarised monolayer.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31492858"> <div itemprop="name">Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Tycko J,Wainberg M,Marinov GK,Ursu O,Hess GT,Ego BK,Li A,Truong A,Trevino AE,Spees K,Yao D,Kaplow IM,Greenside PG,Morgens DW,Phanstiel DH,Snyder MP,Bintu L,Greenleaf WJ,Kundaje A,Bassik MC</div> <div itemprop="description">AM4300 was used in Western Blotting to study off targets effects of essential non-coding element of Crispr-Cas9.</div> <div itemprodp="datePublished">Fri Sep 06 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31434890"> <div itemprop="name">Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yang Y,Willis TL,Button RW,Strang CJ,Fu Y,Wen X,Grayson PRC,Evans T,Sipthorpe RJ,Roberts SL,Hu B,Zhang J,Lu B,Luo S</div> <div itemprop="description">AM4300 was used in Western Blotting to suggests a mechanism of p62 phase condensation by a protein interaction, and indicates that DAXX regulates redox homoeostasis, providing a mechanistic insight into the prosurvival function of DAXX.</div> <div itemprodp="datePublished">Wed Aug 21 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31406177"> <div itemprop="name">Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Burmistrova O,Olias-Arjona A,Lapresa R,Jimenez-Blasco D,Eremeeva T,Shishov D,Romanov S,Zakurdaeva K,Almeida A,Fedichev PO,Bolaños JP</div> <div itemprop="description">AM4300 was used in Western Blotting to show that selective inhibition of PFKFB3 activity by the small molecule AZ67 prevents the NADPH oxidation, redox stress and apoptotic cell death caused by the activation of glycolysis triggered upon excitotoxic and oxygen-glucose deprivation/reoxygenation models in mouse primary neurons.</div> <div itemprodp="datePublished">Mon Aug 12 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30595547"> <div itemprop="name">Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Subileau M,Merdzhanova G,Ciais D,Collin-Faure V,Feige JJ,Bailly S,Vittet D</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the first steps of lymphatic specification and expansion.</div> <div itemprodp="datePublished">Tue Jan 08 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30643138"> <div itemprop="name">Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice.</div> </a> <div itemprop="about">NPJ schizophrenia</div> <div itemprop="author">Graham K,Zhang J,Qiao H,Wu Y,Zhou Y</div> <div itemprop="description">AM4300 was used in Western Blotting to study the association between the inhibition of the 14-3-3 family of proteins in specific forebrain regions with certain schizophrenia-associated endophenotypes.</div> <div itemprodp="datePublished">Mon Jan 14 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30889783"> <div itemprop="name">Fatty Acid Synthesis and Degradation Interplay to Regulate the Oxidative Stress in Cancer Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Mikalayeva V,Ceslevičienė I,Sarapinienė I,Žvikas V,Skeberdis VA,Jakštas V,Bordel S</div> <div itemprop="description">AM4300 was used in Western Blotting to study whether fatty acid synthesis and fatty acid oxidation coexist in breast cancer cells.</div> <div itemprodp="datePublished">Mon Mar 18 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30865891"> <div itemprop="name">Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Kluth O,Stadion M,Gottmann P,Aga H,Jähnert M,Scherneck S,Vogel H,Krus U,Seelig A,Ling C,Gerdes J,Schürmann A</div> <div itemprop="description">AM4300 was used in Western Blot to determine the role of primary cilia on compensatory beta cell replication.</div> <div itemprodp="datePublished">Tue Mar 12 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30651561"> <div itemprop="name">Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zhang H,Savage S,Schultz AR,Bottomly D,White L,Segerdell E,Wilmot B,McWeeney SK,Eide CA,Nechiporuk T,Carlos A,Henson R,Lin C,Searles R,Ho H,Lam YL,Sweat R,Follit C,Jain V,Lind E,Borthakur G,Garcia-Manero G,Ravandi F,Kantarjian HM,Cortes J,Collins R,Buelow DR,Baker SD,Druker BJ,Tyner JW</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the mechanisms of crenolanib resistance in acute myeloid leukaemia.</div> <div itemprodp="datePublished">Wed Jan 16 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31575928"> <div itemprop="name">Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Rué L,Timmers M,Lenaerts A,Smolders S,Poppe L,de Boer A,Van Den Bosch L,Van Damme P,Robberecht W,Lemmens R</div> <div itemprop="description">AM4300 was used in Western Blotting to gain more insights in the cell-specific role of decreasing EphA4 expression in addition to timing and amount of EphA4 reduction.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32395698"> <div itemprop="name">Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.</div> </a> <div itemprop="about">Nature metabolism</div> <div itemprop="author">Wu Z,Oeck S,West AP,Mangalhara KC,Sainz AG,Newman LE,Zhang XO,Wu L,Yan Q,Bosenberg M,Liu Y,Sulkowski PL,Tripple V,Kaech SM,Glazer PM,Shadel GS</div> <div itemprop="description">AM4300 was used in Western Blotting to better understand the nature and downstream consequences of innate immune signalling due to endogenous mtDNA stress.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31817563"> <div itemprop="name">Lemon Peel Polyphenol Extract Reduces Interleukin-6-Induced Cell Migration, Invasiveness, and Matrix Metalloproteinase-9/2 Expression in Human Gastric Adenocarcinoma MKN-28 and AGS Cell Lines.</div> </a> <div itemprop="about">Biomolecules</div> <div itemprop="author">Pagliara V,Nasso R,Di Donato P,Finore I,Poli A,Masullo M,Arcone R</div> <div itemprop="description">AM4300 was used in Western Blotting to analyze the anti-cancer properties of LPE on migration and invasiveness in MKN-28 and AGS human gastric cancer cell lines either in the absence or presence of the pro-inflammatory cytokine IL-6.</div> <div itemprodp="datePublished">Thu Dec 05 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30454647"> <div itemprop="name">Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Grohmann M,Wiede F,Dodd GT,Gurzov EN,Ooi GJ,Butt T,Rasmiena AA,Kaur S,Gulati T,Goh PK,Treloar AE,Archer S,Brown WA,Muller M,Watt MJ,Ohara O,McLean CA,Tiganis T</div> <div itemprop="description">AM4300 was used in Immunohistochemistry to reveal how obesity-associated hepatic oxidative stress can independently contribute to the pathogenesis of non-alcoholic steatohepatitis, fibrosis, and hepatocellular carcinoma.</div> <div itemprodp="datePublished">Thu Nov 15 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29454793"> <div itemprop="name">P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.</div> </a> <div itemprop="about">Gastroenterology</div> <div itemprop="author">Dou C,Liu Z,Tu K,Zhang H,Chen C,Yaqoob U,Wang Y,Wen J,van Deursen J,Sicard D,Tschumperlin D,Zou H,Huang WC,Urrutia R,Shah VH,Kang N</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate whether stiffness due to the presence of tumours increases activation of hepatic stellate cells into myofibroblasts and their tumour-promoting effects.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29649441"> <div itemprop="name">Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Martinez-Guryn K,Hubert N,Frazier K,Urlass S,Musch MW,Ojeda P,Pierre JF,Miyoshi J,Sontag TJ,Cham CM,Reardon CA,Leone V,Chang EB</div> <div itemprop="description">AM4300 was used in Western Blotting to study the contribution of the small bowel microbiota of mammals to diet-microbe interactions, including lipid metabolism and absorption.</div> <div itemprodp="datePublished">Wed Apr 11 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30397325"> <div itemprop="name">Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Cheng Y,Wang ZM,Tan W,Wang X,Li Y,Bai B,Li Y,Zhang SF,Yan HL,Chen ZL,Liu CM,Mi TW,Xia S,Zhou Z,Liu A,Tang GB,Liu C,Dai ZJ,Wang YY,Wang H,Wang X,Kang Y,Lin L,Chen Z,Xie N,Sun Q,Xie W,Peng J,Chen D,Teng ZQ,Jin P</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the impact of miR-137 loss-of-function in vivo.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30017585"> <div itemprop="name">The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression.</div> </a> <div itemprop="about">Molecular cell</div> <div itemprop="author">Nikopoulou C,Panagopoulos G,Sianidis G,Psarra E,Ford E,Thanos D</div> <div itemprop="description">AM4300 was used in Western Blotting to show that the transcription factor ThPOK binds cooperatively with NF-κB to NRCs and mediates their physical proximity with the IFNB1 gene via its ability to oligomerize when bound to DNA.</div> <div itemprodp="datePublished">Thu Jul 19 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29860338"> <div itemprop="name">The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.</div> </a> <div itemprop="about">Nucleic acids research</div> <div itemprop="author">Abshire ET,Chasseur J,Bohn JA,Del Rizzo PA,Freddolino PL,Goldstrohm AC,Trievel RC</div> <div itemprop="description">AM4300 was used in Western Blotting to study the mechanisms by which Nocturnin regulates high-fat diet induced weight gain, and bone formation.</div> <div itemprodp="datePublished">Fri Jul 06 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30374086"> <div itemprop="name">SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation.</div> </a> <div itemprop="about">Nature structural & molecular biology</div> <div itemprop="author">Vendramin R,Verheyden Y,Ishikawa H,Goedert L,Nicolas E,Saraf K,Armaos A,Delli Ponti R,Izumikawa K,Mestdagh P,Lafontaine DLJ,Tartaglia GG,Takahashi N,Marine JC,Leucci E</div> <div itemprop="description">AM4300 was used in Western Blotting to highlight how a single oncogenic lncRNA can simultaneously modulate RNA-protein complex formation in two distinct cellular compartments to promote cell growth.</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29415205"> <div itemprop="name">HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Benoy V,Van Helleputte L,Prior R,d'Ydewalle C,Haeck W,Geens N,Scheveneels W,Schevenels B,Cader MZ,Talbot K,Kozikowski AP,Vanden Berghe P,Van Damme P,Robberecht W,Van Den Bosch L</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that α-tubulin deacetylation and disrupted axonal transport may represent a common pathogenic mechanism underlying Charcot-Marie-Tooth disease.</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29581096"> <div itemprop="name">p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Wang G,Zhu H,Situ C,Han L,Yu Y,Cheung TH,Liu K,Wu Z</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the extrinsic cues and intrinsic signalling pathways that regulate quiescence exit during adult mouse muscle satellite cell activation.</div> <div itemprodp="datePublished">Fri Apr 13 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29669863"> <div itemprop="name">Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">He X,Kläsener K,Iype JM,Becker M,Maity PC,Cavallari M,Nielsen PJ,Yang J,Reth M</div> <div itemprop="description">AM4300 was used in Western Blotting to show that Igβ and CD19 are part of an alternative B-cell signalling module that use continuous ITAM/PI3K signalling to promote the survival of B lymphoma and normal B cells.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29290587"> <div itemprop="name">RAPGEF5 Regulates Nuclear Translocation of β-Catenin.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Griffin JN,Del Viso F,Duncan AR,Robson A,Hwang W,Kulkarni S,Liu KJ,Khokha MK</div> <div itemprop="description">AM4300 was used in Western Blotting to study the mechanisms regulating Β-catenin nuclear transport.</div> <div itemprodp="datePublished">Mon Jan 22 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29963746"> <div itemprop="name">FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Alvarez-Garcia O,Matsuzaki T,Olmer M,Miyata K,Mokuda S,Sakai D,Masuda K,Asahara H,Lotz MK</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the function of FOXO in intervertebral disk ageing and age-related degeneration.</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29672864"> <div itemprop="name">Menin regulates the serine biosynthetic pathway in Ewing sarcoma.</div> </a> <div itemprop="about">The Journal of pathology</div> <div itemprop="author">Svoboda LK,Teh SSK,Sud S,Kerk S,Zebolsky A,Treichel S,Thomas D,Halbrook CJ,Lee HJ,Kremer D,Zhang L,Klossowski S,Bankhead AR,Magnuson B,Ljungman M,Cierpicki T,Grembecka J,Lyssiotis CA,Lawlor ER</div> <div itemprop="description">AM4300 was used in Western Blotting to study the mechanistic basis of menin-MLL-mediated oncogenic activity in Ewing sarcoma.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29991649"> <div itemprop="name">Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.</div> </a> <div itemprop="about">Science signaling</div> <div itemprop="author">Zhang Y,Lee JH,Paull TT,Gehrke S,D'Alessandro A,Dou Q,Gladyshev VN,Schroeder EA,Steyl SK,Christian BE,Shadel GS</div> <div itemprop="description">AM4300 was used in Western Blotting to propose that loss of the mitochondrial ROS-sensing function of ATM may cause cellular ROS accumulation and oxidative stress in A-T.</div> <div itemprodp="datePublished">Tue Jul 10 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30018082"> <div itemprop="name">Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.</div> </a> <div itemprop="about">Science signaling</div> <div itemprop="author">Jenkins C,Luty SB,Maxson JE,Eide CA,Abel ML,Togiai C,Nemecek ER,Bottomly D,McWeeney SK,Wilmot B,Loriaux M,Chang BH,Tyner JW</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that TNK2 is a promising therapeutic target for PTPN11-mutant leukemias.</div> <div itemprodp="datePublished">Tue Jul 17 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29027761"> <div itemprop="name">Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease.</div> </a> <div itemprop="about">Brain pathology (Zurich, Switzerland)</div> <div itemprop="author">Ruiz M,Bégou M,Launay N,Ranea-Robles P,Bianchi P,López-Erauskin J,Morató L,Guilera C,Petit B,Vaurs-Barriere C,Guéret-Gonthier C,Bonnet-Dupeyron MN,Fourcade S,Auwerx J,Boespflug-Tanguy O,Pujol A</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the link between redox and metabolic homeostasis in myelin diseases.</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29624862"> <div itemprop="name">The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E-transformed cells.</div> </a> <div itemprop="about">Molecular oncology</div> <div itemprop="author">Furlan T,Khalid S,Nguyen AV,Günther J,Troppmair J</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that phosphorylation-activated p66Shc functions as a tumor suppressor in melanoma cells.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30325015"> <div itemprop="name">CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro.</div> </a> <div itemprop="about">International journal of cancer</div> <div itemprop="author">Luo J,Chimge NO,Zhou B,Flodby P,Castaldi A,Firth AL,Liu Y,Wang H,Yang C,Marconett CN,Crandall ED,Offringa IA,Frenkel B,Borok Z</div> <div itemprop="description">AM4300 was used in Western Blot to indicate a tumor suppressor role for CLDN18.1 in LuAd mediated by a regulatory network that encompasses YAP/TAZ, IGF-1R and AKT signaling.</div> <div itemprodp="datePublished">Sat Dec 15 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30389848"> <div itemprop="name">Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Samarajeewa A,Lenz DR,Xie L,Chiang H,Kirchner R,Mulvaney JF,Edge ASB,Dabdoub A</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that Wnt activation promotes supporting cell proliferation following birth, but prior to postnatal day 5.</div> <div itemprodp="datePublished">Tue Nov 27 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29866901"> <div itemprop="name">Notch1 is asymmetrically distributed from the beginning of embryogenesis and controls the ventral center.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Castro Colabianchi AM,Revinski DR,Encinas PI,Baez MV,Monti RJ,Rodríguez Abinal M,Kodjabachian L,Franchini LF,López SL</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that ventral enrichment of Notch1 underlies the process by which Notch1 participates in restricting nuclear accumulation of Β-catenin to the dorsal side.</div> <div itemprodp="datePublished">Tue Jul 17 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30327324"> <div itemprop="name">Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Love AM,Prince DJ,Jessen JR</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of Vang-like 2 on the regulation of membrane-protusive activities in migrating gastrula cells.</div> <div itemprodp="datePublished">Thu Nov 15 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29142133"> <div itemprop="name">Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Inturi R,Mun K,Singethan K,Schreiner S,Punga T</div> <div itemprop="description">AM4300 was used in Western Blotting to identify several cellular proteins interacting with the human Adenovirus precursor pVII protein.</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30297705"> <div itemprop="name">β<sub>2</sub>-Adrenergic receptor modulates mitochondrial metabolism and disease progression in recurrent/metastatic HPV(+) HNSCC.</div> </a> <div itemprop="about">Oncogenesis</div> <div itemprop="author">Lucido CT,Callejas-Valera JL,Colbert PL,Vermeer DW,Miskimins WK,Spanos WC,Vermeer PD</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that an aggressive murine model of recurrent/metastatic human papillomavirus-associated head and neck squamous cell carcinoma upregulates Β2-adrenergic receptor expression, concordant with significantly heightened mitochondrial metabolism.</div> <div itemprodp="datePublished">Mon Oct 08 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29778605"> <div itemprop="name">Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.</div> </a> <div itemprop="about">Journal of molecular biology</div> <div itemprop="author">Hunter MR,Hesketh GG,Benedyk TH,Gingras AC,Graham SC</div> <div itemprop="description">AM4300 was used in Western Blotting to identify proteins associating with both VPS33A and VPS33B, suggesting that these proteins have distinct sub-cellular localisations.</div> <div itemprodp="datePublished">Fri Jul 06 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29530860"> <div itemprop="name">Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells <i>In Vitro</i>.</div> </a> <div itemprop="about">Antimicrobial agents and chemotherapy</div> <div itemprop="author">Kitano M,Hosmillo M,Emmott E,Lu J,Goodfellow I</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that mutations in the norovirus protease that lead to the generation of resistant mutants can rapidly occur.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29301945"> <div itemprop="name">Modulation of glutathione promotes apoptosis in triple-negative breast cancer cells.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Miran T,Vogg ATJ,Drude N,Mottaghy FM,Morgenroth A</div> <div itemprop="description">AM4300 was used in Western Blotting to evaluate the potential of pharmacological GSH depletion to sensitize CSCs to ionizing radiotherapy with an I-125-labeled nucleoside analog, 5-iodo-4'-thio-2'-deoxyuridine.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29868845"> <div itemprop="name">Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Dominguez Gonzalez B,Billion K,Rous S,Pavie B,Lange C,Goodchild R</div> <div itemprop="description">AM4300 was used in Immunohistochemistry to predict human TOR1A disease will include incompletely penetrant defects in embryonic brain morphogenesis in cases where mutations ablate TOR1A function.</div> <div itemprodp="datePublished">Fri Jun 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29668927"> <div itemprop="name">Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Choi JC,Wu W,Phillips E,Plevin R,Sera F,Homma S,Worman HJ</div> <div itemprop="description">AM4300 was used in Western Blotting to show that female LmnaH222P/H222P mice have increased Dusp4 expression and hyperactivation of extracellular signal-regulated kinase 1/2 with delayed kinetics relative to male mice, consistent with the sex-dependent delay in the onset and progression of disease.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29133460"> <div itemprop="name">Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Peng W,Furuuchi N,Aslanukova L,Huang YH,Brown SZ,Jiang W,Addya S,Vishwakarma V,Peters E,Brody JR,Dixon DA,Sawicki JA</div> <div itemprop="description">AM4300 was used in Western Blot to explore the consequences of human antigen R (HuR) overexpression using a novel transgenic mouse model that has a >2-fold elevation of pancreatic HuR expression.</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29726995"> <div itemprop="name">The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine.</div> </a> <div itemprop="about">Endocrinology</div> <div itemprop="author">Roof AK,Jirawatnotai S,Trudeau T,Kuzyk C,Wierman ME,Kiyokawa H,Gutierrez-Hartmann A</div> <div itemprop="description">AM4300 was used in Western Blotting to study the mechanism by which dopamine antagonists inhibit lactotrope proliferation.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30169756"> <div itemprop="name">KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner.</div> </a> <div itemprop="about">Cerebral cortex (New York, N.Y. : 1991)</div> <div itemprop="author">Awad PN,Amegandjin CA,Szczurkowska J,Carriço JN,Fernandes do Nascimento AS,Baho E,Chattopadhyaya B,Cancedda L,Carmant L,Di Cristo G</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate whether KCC2 regulation of dendritic spine development, and its underlying mechanisms, are brain-region specific.</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29573052"> <div itemprop="name">A homozygous variant disrupting the PIGH start-codon is associated with developmental delay, epilepsy, and microcephaly.</div> </a> <div itemprop="about">Human mutation</div> <div itemprop="author">Pagnamenta AT,Murakami Y,Anzilotti C,Titheradge H,Oates AJ,Morton J,Kinoshita T,Kini U,Taylor JC</div> <div itemprop="description">AM4300 was used in Western Blotting to characterise a homozygous c.1A > T variant resulting in defective glycosylphosphatidylinositol-anchor biogenesis and highlight the importance of exploring low-coverage variants within autozygous regions.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29652636"> <div itemprop="name">HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction.</div> </a> <div itemprop="about">Physiological genomics</div> <div itemprop="author">Williams AL,Khadka V,Tang M,Avelar A,Schunke KJ,Menor M,Shohet RV</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the transcriptional response after myocardial infarction and to identify novel, hypoxia-driven changes, including alternative splicing.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29743299"> <div itemprop="name">The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac Ca<sub>V</sub>1.2 calcium channels.</div> </a> <div itemprop="about">The Journal of general physiology</div> <div itemprop="author">Yu H,Yuan C,Westenbroek RE,Catterall WA</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the role of the A-kinase anchoring protein Cypher/Zasp in Β-adrenergic regulation of CaV1.2 channels.</div> <div itemprodp="datePublished">Mon Jun 04 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29268082"> <div itemprop="name">Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.</div> </a> <div itemprop="about">Virology</div> <div itemprop="author">Schulte B,Selyutina A,Opp S,Herschhorn A,Sodroski JG,Pizzato M,Diaz-Griffero F</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the exact mechanism by which SERINC5 restricts HIV-1.</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30043283"> <div itemprop="name">Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice.</div> </a> <div itemprop="about">Digestive diseases and sciences</div> <div itemprop="author">Farooq SM,Hou Y,Li H,O'Meara M,Wang Y,Li C,Wang JM</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that GPR35 could play a crucial role in protecting from colonic inflammation and serve as a therapeutic target.</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30187469"> <div itemprop="name">Low temperature decreases bone mass in mice: Implications for humans.</div> </a> <div itemprop="about">American journal of physical anthropology</div> <div itemprop="author">Robbins A,Tom CATMB,Cosman MN,Moursi C,Shipp L,Spencer TM,Brash T,Devlin MJ</div> <div itemprop="description">AM4300 was used in Western Blotting to show that chronic exposure to low temperature impairs bone architecture, suggesting climate may contribute to phenotypic variation in humans and other hominins.</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30647761"> <div itemprop="name">Nutmeg Extract Increases Skeletal Muscle Mass in Aging Rats Partly via IGF1-AKT-mTOR Pathway and Inhibition of Autophagy.</div> </a> <div itemprop="about">Evidence-based complementary and alternative medicine : eCAM</div> <div itemprop="author">Pratiwi YS,Lesmana R,Goenawan H,Sylviana N,Setiawan I,Tarawan VM,Lestari K,Abdulah R,Dwipa L,Purba A,Supratman U</div> <div itemprop="description">AM4300 was used in Western Blotting to study the physiological health benefit of nutmeg extract during ageing, especially in the myogenesis process in skeletal muscle.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30024985"> <div itemprop="name">Murine macrophage TLR2-FcγR synergy via FcγR licensing of IL-6 cytokine mRNA ribosome binding and translation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Hunt D,Drake LA,Drake JR</div> <div itemprop="description">AM4300 was used in Western Blotting to study FcγR regulation of TLR2-driven production of IL-6.</div> <div itemprodp="datePublished">Tue Jan 22 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30440051"> <div itemprop="name">CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Walker SJ,Selfors LM,Margolis BL,Brugge JS</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effects of ectopic expression of CRB3 in mammary epithelial cells.</div> <div itemprodp="datePublished">Tue Apr 16 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29615491"> <div itemprop="name">Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Li W,Tam KMV,Chan WWR,Koon AC,Ngo JCK,Chan HYE,Lau KF</div> <div itemprop="description">AM4300 was used in Western Blotting to identify a novel mechanism by which FE65 stimulates Rac1-mediated neurite outgrowth through recruiting and activating of ELMO1.</div> <div itemprodp="datePublished">Fri May 18 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29545601"> <div itemprop="name">TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Archbold HC,Jackson KL,Arora A,Weskamp K,Tank EM,Li X,Miguez R,Dayton RD,Tamir S,Klein RL,Barmada SJ</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that redundant pathways regulate TDP43 nuclear export, and prevention of cytoplasmic TDP43 accumulation may be enhanced by targeting overlapping mechanisms.</div> <div itemprodp="datePublished">Thu Mar 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30464239"> <div itemprop="name">Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Carreira MC,Andrade S,Gonzalez-Izquierdo A,Amil M,Folgueira C,Monteiro MP,Sanz E,Crujeiras AB,Casanueva FF</div> <div itemprop="description">AM4300 was used in Western Blotting to study the anti-obesity effects of OBEX, and the mechanisms governing these effects.</div> <div itemprodp="datePublished">Wed Nov 21 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30042151"> <div itemprop="name">Mouse Homolog of the Human <i>TP53</i> R337H Mutation Reveals Its Role in Tumorigenesis.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Park JH,Li J,Starost MF,Liu C,Zhuang J,Chen J,Achatz MI,Kang JG,Wang PY,Savage SA,Hwang PM</div> <div itemprop="description">AM4300 was used in Western Blot to show that the human R337H mutation can compromise p53 activity and promote tumorigenesis.</div> <div itemprodp="datePublished">Sat Sep 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29203237"> <div itemprop="name">Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes.</div> </a> <div itemprop="about">Molecular metabolism</div> <div itemprop="author">Rödiger M,Werno MW,Wilhelmi I,Baumeier C,Hesse D,Wettschureck N,Offermanns S,Song K,Krauß M,Schürmann A</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate the role of the trans-Golgi localised monomeric GTPase ARFRP1 in endosomal-mediated vesicle trafficking of mature adipocytes.</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29588466"> <div itemprop="name">Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Mancini SJ,Boyd D,Katwan OJ,Strembitska A,Almabrouk TA,Kennedy S,Palmer TM,Salt IP</div> <div itemprop="description">AM4300 was used in Western Blotting to examine whether sodium-glucose co-transporter-2 inhibitors attenuate inflammatory signalling in cultured human endothelial cells.</div> <div itemprodp="datePublished">Tue Mar 27 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30250019"> <div itemprop="name">Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Russo R,Varano GP,Adornetto A,Nazio F,Tettamanti G,Girardello R,Cianfanelli V,Cavaliere F,Morrone LA,Corasaniti MT,Cecconi F,Bagetta G,Nucci C</div> <div itemprop="description">AM4300 was used in Western Blotting to analyse the autophagic response in the retinas of mice subjected to ischemia induced by transient elevation of intraocular pressure, reporting a biphasic and reperfusion time-dependent modulation of the process.</div> <div itemprodp="datePublished">Mon Sep 24 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29945972"> <div itemprop="name">Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Martina JA,Puertollano R</div> <div itemprop="description">AM4300 was used in Western Blotting to show oxidative stress induces protein phosphatase 2A-mediated activation of transcription factor EB and IGHM enhancer 3 which regulate stress pathways.</div> <div itemprodp="datePublished">Fri Aug 10 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30239049"> <div itemprop="name">Nuclear transglutaminase 2 directly regulates expression of cathepsin S in rat cortical neurons.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Ji C,Tang M,Harrison J,Paciorkowski A,Johnson GVW</div> <div itemprop="description">AM4300 was used in Western Blotting to illustrate that TG2 plays a role in promoting neuron health in part by repressing the expression of cathepsin S.</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30082832"> <div itemprop="name">A novel probe to assess cytosolic entry of exogenous proteins.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lu Q,Grotzke JE,Cresswell P</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that antigen dislocation into the cytosol is the rate limiting step in cross-presentation.</div> <div itemprodp="datePublished">Mon Aug 06 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30487791"> <div itemprop="name">Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Liang J,Jahraus B,Balta E,Ziegler JD,Hübner K,Blank N,Niesler B,Wabnitz GH,Samstag Y</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that sulphoraphane induces a pro-oxidative state in untransformed human T-cells of healthy donors or rheumatoid arthritis patients.</div> <div itemprodp="datePublished">Tue Oct 08 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30404013"> <div itemprop="name">The α<sub>2</sub>δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α<sub>2</sub>δ-1.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Dahimene S,Page KM,Kadurin I,Ferron L,Ho DY,Powell GT,Pratt WS,Wilson SW,Dolphin AC</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that Cachd1 influences both CaV2.2 trafficking and function and can inhibit responses to α2δ-1.</div> <div itemprodp="datePublished">Tue Nov 06 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30082317"> <div itemprop="name">The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Rodríguez-Castañeda F,Lemma RB,Cuervo I,Bengtsen M,Moen LM,Ledsaak M,Eskeland R,Gabrielsen OS</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of sentrin-specific protease 1 in activating gene expression.</div> <div itemprodp="datePublished">Fri Oct 05 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30082317"> <div itemprop="name">The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Rodríguez-Castañeda F,Lemma RB,Cuervo I,Bengtsen M,Moen LM,Ledsaak M,Eskeland R,Gabrielsen OS</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of sentrin-specific protease 1 in activating gene expression.</div> <div itemprodp="datePublished">Fri Oct 05 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29479319"> <div itemprop="name">High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.</div> </a> <div itemprop="about">Frontiers in physiology</div> <div itemprop="author">Almabrouk TAM,White AD,Ugusman AB,Skiba DS,Katwan OJ,Alganga H,Guzik TJ,Touyz RM,Salt IP,Kennedy S</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the mechanisms by which a high fat diet reduces the anticontractile effect of aortic perivascular adipose tissue in mice.</div> <div itemprodp="datePublished">Sat Jan 29 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30327461"> <div itemprop="name">Cancer exosomes induce tumor innervation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Madeo M,Colbert PL,Vermeer DW,Lucido CT,Cain JT,Vichaya EG,Grossberg AJ,Muirhead D,Rickel AP,Hong Z,Zhao J,Weimer JM,Spanos WC,Lee JH,Dantzer R,Vermeer PD</div> <div itemprop="description">AM4300 was used in Western Blotting to study whether, in some tumours, nerves are acquired by a tumour-induced process, called axonogenesis.</div> <div itemprodp="datePublished">Tue Oct 16 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29880921"> <div itemprop="name">Mouse medulloblastoma driven by CRISPR activation of cellular Myc.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Vo BT,Kwon JA,Li C,Finkelstein D,Xu B,Orr BA,Sherr CJ,Roussel MF</div> <div itemprop="description">AM4300 was used in Western Blotting to develop a mouse model of MYC-driven Group 3 medulloblastoma.</div> <div itemprodp="datePublished">Thu Jun 07 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29752437"> <div itemprop="name">Caspase-mediated cleavage of the centrosomal proteins during apoptosis.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Seo MY,Rhee K</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that caspase-specific cleavage of SAS-6 and pericentrin may be linked to the functional disruption of the centrosome during apoptosis.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29581864"> <div itemprop="name">Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Bustos SO,da Silva Pereira GJ,de Freitas Saito R,Gil CD,Zanatta DB,Smaili SS,Chammas R</div> <div itemprop="description">AM4300 was used in Western Blotting to show that the autophagic flux is dependent on Gal-3 levels, which attenuate the prosurvival role of autophagy.</div> <div itemprodp="datePublished">Tue Mar 06 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30046388"> <div itemprop="name">Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Roelants C,Giacosa S,Pillet C,Bussat R,Champelovier P,Bastien O,Guyon L,Arnoux V,Cochet C,Filhol O</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that combined inhibition of PI3K and Src impedes cell growth and invasion, and induces cell death of renal carcinoma cells.</div> <div itemprodp="datePublished">Tue Jul 10 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29636413"> <div itemprop="name">Dimerization of the cellular prion protein inhibits propagation of scrapie prions.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Engelke AD,Gonsberg A,Thapa S,Jung S,Ulbrich S,Seidel R,Basu S,Multhaup G,Baier M,Engelhard M,Schätzl HM,Winklhofer KF,Tatzelt J</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effect of pathogenic mutations on dimerisation in the hydrophobic domain of the cellular prion protein.</div> <div itemprodp="datePublished">Fri May 25 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29472835"> <div itemprop="name">Decreased Hippocampal Neuroplasticity and Behavioral Impairment in an Animal Model of Inhalant Abuse.</div> </a> <div itemprop="about">Frontiers in neuroscience</div> <div itemprop="author">Malloul H,Bennis M,Bonzano S,Gambarotta G,Perroteau I,De Marchis S,Ba-M'hamed S</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate significant structural and molecular changes in the adult mice hippocampus after prolonged paint thinner inhalation.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28459437"> <div itemprop="name">Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Toussaint M,Jackson DJ,Swieboda D,Guedán A,Tsourouktsoglou TD,Ching YM,Radermecker C,Makrinioti H,Aniscenko J,Bartlett NW,Edwards MR,Solari R,Farnir F,Papayannopoulos V,Bureau F,Marichal T,Johnston SL</div> <div itemprop="description">AM4300 was used in Western Blotting to study how respiratory viral infections boost the type-2 immune response strongly implicated in asthma exacerbation.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28446517"> <div itemprop="name">A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure.</div> </a> <div itemprop="about">Circulation</div> <div itemprop="author">Aubdool AA,Thakore P,Argunhan F,Smillie SJ,Schnelle M,Srivastava S,Alawi KM,Wilde E,Mitchell J,Farrell-Dillon K,Richards DA,Maltese G,Siow RC,Nandi M,Clark JE,Shah AM,Sams A,Brain SD</div> <div itemprop="description">AM4300 was used in Western Blotting to evaluate whether a novel acylated α-calcitonin gene-related peptide analogue can alleviate and reverse cardiovascular disease in 2 distinct murine models of hypertension and heart failure in vivo.</div> <div itemprodp="datePublished">Tue Jul 25 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28292439"> <div itemprop="name">Integrated Molecular Characterization of Uterine Carcinosarcoma.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Cherniack AD,Shen H,Walter V,Stewart C,Murray BA,Bowlby R,Hu X,Ling S,Soslow RA,Broaddus RR,Zuna RE,Robertson G,Laird PW,Kucherlapati R,Mills GB,Weinstein JN,Zhang J,Akbani R,Levine DA</div> <div itemprop="description">AM4300 was used in reverse phase protein array to characterize the molecular identity of uterine carcinosarcomas.</div> <div itemprodp="datePublished">Mon Mar 13 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28683291"> <div itemprop="name">Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment.</div> </a> <div itemprop="about">Cell metabolism</div> <div itemprop="author">Testoni G,Duran J,García-Rocha M,Vilaplana F,Serrano AL,Sebastián D,López-Soldado I,Sullivan MA,Slebe F,Vilaseca M,Muñoz-Cánoves P,Guinovart JJ</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effects of glycogenin deficiency on glycogen accumulation and muscle function in mice.</div> <div itemprodp="datePublished">Wed Jul 05 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28384478"> <div itemprop="name">The Retromer Supports AMPA Receptor Trafficking During LTP.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Temkin P,Morishita W,Goswami D,Arendt K,Chen L,Malenka R</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate a role for the endosomal sorting complex in the trafficking of AMPA receptors during NMDA-receptor-dependent LTP at mature hippocampal synapses.</div> <div itemprodp="datePublished">Wed Apr 05 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28669544"> <div itemprop="name">TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.</div> </a> <div itemprop="about">Neuron</div> <div itemprop="author">Paolicelli RC,Jawaid A,Henstridge CM,Valeri A,Merlini M,Robinson JL,Lee EB,Rose J,Appel S,Lee VM,Trojanowski JQ,Spires-Jones T,Schulz PE,Rajendran L</div> <div itemprop="description">AM4300 was used in Western Blot to investigate whether increased microglial phagocytic activity that clears amyloid can also cause pathological synapse loss.</div> <div itemprodp="datePublished">Wed Jul 19 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28945249"> <div itemprop="name">Mechanism and regulation of the Lys6-selective deubiquitinase USP30.</div> </a> <div itemprop="about">Nature structural & molecular biology</div> <div itemprop="author">Gersch M,Gladkova C,Schubert AF,Michel MA,Maslen S,Komander D</div> <div itemprop="description">AM4300 was used in Western Blotting to study the mechanism and regulation of the Lys6-selective deubiquitinase USP30.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27780308"> <div itemprop="name">Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage.</div> </a> <div itemprop="about">Arthritis & rheumatology (Hoboken, N.J.)</div> <div itemprop="author">Hasegawa A,Yonezawa T,Taniguchi N,Otabe K,Akasaki Y,Matsukawa T,Saito M,Neo M,Marmorstein LY,Lotz MK</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the expression patterns of fibulin 3 in ageing-related joint changes, and determine its role in the pathogenesis of osteoarthritis.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27780308"> <div itemprop="name">Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage.</div> </a> <div itemprop="about">Arthritis & rheumatology (Hoboken, N.J.)</div> <div itemprop="author">Hasegawa A,Yonezawa T,Taniguchi N,Otabe K,Akasaki Y,Matsukawa T,Saito M,Neo M,Marmorstein LY,Lotz MK</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the expression patterns of fibulin 3 in ageing-related joint changes, and determine its role in the pathogenesis of osteoarthritis.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28398476"> <div itemprop="name">Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Vicente Miranda H,Szego ÉM,Oliveira LMA,Breda C,Darendelioglu E,de Oliveira RM,Ferreira DG,Gomes MA,Rott R,Oliveira M,Munari F,Enguita FJ,Simões T,Rodrigues EF,Heinrich M,Martins IC,Zamolo I,Riess O,Cordeiro C,Ponces-Freire A,Lashuel HA,Santos NC,Lopes LV,Xiang W,Jovin TM,Penque D,Engelender S,Zweckstetter M,Klucken J,Giorgini F,Quintas A,Outeiro TF</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate glycation constitutes a novel drug target that can be explored in synucleinopathies as well as in other neurodegenerative conditions.</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27612995"> <div itemprop="name">Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Fu H,Tian Y,Zhou L,Zhou D,Tan RJ,Stolz DB,Liu Y</div> <div itemprop="description">AM4300 was used in Western Blotting to determine whether tenascin-C is a component of the fibrogenic niche in kidney fibrosis.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29161592"> <div itemprop="name">Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Bajikar SS,Wang CC,Borten MA,Pereira EJ,Atkins KA,Janes KA</div> <div itemprop="description">AM4300 was used in Western Blotting to study the tumour-suppressive mode of action of growth-differentiation factor 11, and an unusual mechanism of its inactivation in triple negative breast cancer.</div> <div itemprodp="datePublished">Mon Nov 20 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28535373"> <div itemprop="name">A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">An Y,Wang G,Diao Y,Long Y,Fu X,Weng M,Zhou L,Sun K,Cheung TH,Ip NY,Sun H,Wang H,Wu Z</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the regulation of cell fate between muscle progenitor cells to brown adipocytes.</div> <div itemprodp="datePublished">Mon May 22 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28770320"> <div itemprop="name">FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.</div> </a> <div itemprop="about">Diabetologia</div> <div itemprop="author">Laeger T,Baumeier C,Wilhelmi I,Würfel J,Kamitz A,Schürmann A</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate whether exogenous fibroblast growth factor 21 is sufficient to prevent diabetes and beta cell loss in New Zealand obese mice.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28257421"> <div itemprop="name">The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.</div> </a> <div itemprop="about">PLoS biology</div> <div itemprop="author">de Oliveira RM,Vicente Miranda H,Francelle L,Pinho R,Szegö ÉM,Martinho R,Munari F,Lázaro DF,Moniot S,Guerreiro P,Fonseca-Ornelas L,Marijanovic Z,Antas P,Gerhardt E,Enguita FJ,Fauvet B,Penque D,Pais TF,Tong Q,Becker S,Kügler S,Lashuel HA,Steegborn C,Zweckstetter M,Outeiro TF</div> <div itemprop="description">AM4300 was used in western blot to analyze the mechanistic relationship between sirtuin 2 and alpha-synuclein in Parkinson's disease</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27181209"> <div itemprop="name">Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Bianchi-Smiraglia A,Bagati A,Fink EE,Moparthy S,Wawrzyniak JA,Marvin EK,Battaglia S,Jowdy P,Kolesnikova M,Foley CE,Berman AE,Kozlova NI,Lipchick BC,Paul-Rosner LM,Bshara W,Ackroyd JJ,Shewach DS,Nikiforov MA</div> <div itemprop="description">AM4300 was used in western blot to study suppression invasion by reduction of intracellular GTP pools via a microphthalmia-associated transcription factor</div> <div itemprodp="datePublished">Thu Jan 05 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28626000"> <div itemprop="name">BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Zhang X,Jiang S,Mitok KA,Li L,Attie AD,Martin TFJ</div> <div itemprop="description">AM4300 was used in Western Blotting to identify C2 domain-containing proteins involved in the regulation of Ca(2+)-dependent dense-core vesicle exocytosis in neuroendocrine cells.</div> <div itemprodp="datePublished">Mon Jul 03 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27884645"> <div itemprop="name">Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes.</div> </a> <div itemprop="about">Osteoarthritis and cartilage</div> <div itemprop="author">Akagi R,Akatsu Y,Fisch KM,Alvarez-Garcia O,Teramura T,Muramatsu Y,Saito M,Sasho T,Su AI,Lotz MK</div> <div itemprop="description">AM4300 was used in western blot to study circadian rhythmicity in cultured chondrocytes and determine the role of NR1D1 and BMAL1 in regulating chondrocyte functions</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28028198"> <div itemprop="name">Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Bender RA,Zhou L,Vierk R,Brandt N,Keller A,Gee CE,Schäfer MK,Rune GM</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that neuron-derived E2 modulates synaptic plasticity in rodent basolateral amygdala (BLA) sex-dependently.</div> <div itemprodp="datePublished">Wed Feb 08 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28490590"> <div itemprop="name">The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Huffman JB,Daniel GR,Falck-Pedersen E,Huet A,Smith GA,Conway JF,Homa FL</div> <div itemprop="description">AM4300 was used in Western Blotting to identify pUL25 as a key viral factor for genome uncoating.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28440909"> <div itemprop="name">Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes.</div> </a> <div itemprop="about">Cancer science</div> <div itemprop="author">Yoshimatsu Y,Nakahara T,Tanaka K,Inagawa Y,Narisawa-Saito M,Yugawa T,Ohno SI,Fujita M,Nakagama H,Kiyono T</div> <div itemprop="description">AM4300 was used in Western Blotting to understand the role of the PDZ-binding motif of HPV16 E6 protein in the oncogenic transformation of human cervical keratinocytes.</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27840081"> <div itemprop="name">Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Wang R,Ding Q,De Assuncao TM,Mounajjed T,Maiers JL,Dou C,Cao S,Yaqoob U,Huebert RC,Shah VH</div> <div itemprop="description">AM4300 was used in Western Blotting to determine whether Dynamin-2 with lysine44 converted to alanine, expression in hepatic stellate cells (HSC) would decrease HSC activation and fibrogenesis in vivo by disrupting receptor tyrosine kinase endocytosis and signalling.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28886967"> <div itemprop="name">Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.</div> </a> <div itemprop="about">Journal of molecular and cellular cardiology</div> <div itemprop="author">Blakeslee WW,Lin YH,Stratton MS,Tatman PD,Hu T,Ferguson BS,McKinsey TA</div> <div itemprop="description">AM4300 was used in Western Blotting to define a novel role for class I histone deacetylases in the control of the JIP1/kinesin axis in cardiomyocytes.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28159899"> <div itemprop="name">Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH</div> <div itemprop="description">AM4300 was used in Western Blotting to identify the functional role of collectrin in the liver.</div> <div itemprodp="datePublished">Wed Mar 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27852743"> <div itemprop="name">Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Takacs E,Boto P,Simo E,Csuth TI,Toth BM,Raveh-Amit H,Pap A,Kovács EG,Kobolak J,Benkö S,Dinnyes A,Szatmari I</div> <div itemprop="description">AM4300 was used in Western Blotting to find that ex vivo-generated embryonic stem cell-derived dendritic cells have a compromised maturation ability and immunogenicity.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29113998"> <div itemprop="name">RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Egami Y,Kawai K,Araki N</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that RhoC modulates phagosome formation be modifying actin cytoskeletal remodeling via mDia1.</div> <div itemprodp="datePublished">Fri Dec 15 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28754687"> <div itemprop="name">Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Zimmerman SP,Asokan SB,Kuhlman B,Bear JE</div> <div itemprop="description">AM4300 was used in Western Blotting to find that a remarkably small amount of fibronectin is necessary to support stable GTPase-driven lamellipodia formation.</div> <div itemprodp="datePublished">Fri Sep 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28562169"> <div itemprop="name">PLK4 phosphorylation of CP110 is required for efficient centriole assembly.</div> </a> <div itemprop="about">Cell cycle (Georgetown, Tex.)</div> <div itemprop="author">Lee M,Seo MY,Chang J,Hwang DS,Rhee K</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal that polo-like kinase 4 specifically phosphorylates CP110 at the S98 position.</div> <div itemprodp="datePublished">Sun Jun 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27148961"> <div itemprop="name">Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.</div> </a> <div itemprop="about">Molecular carcinogenesis</div> <div itemprop="author">Scott TL,Wicker CA,Suganya R,Dhar B,Pittman T,Horbinski C,Izumi T</div> <div itemprop="description">AM4300 was used in western blot to study how Parkin is responsible for polyubiquitination of apurinic/apyrimidinic endonuclease 1</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28040728"> <div itemprop="name">Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Khosravi B,Hartmann H,May S,Möhl C,Ederle H,Michaelsen M,Schludi MH,Dormann D,Edbauer D</div> <div itemprop="description">AM4300 was used in Western Blotting to study how compact cytoplasmic poly-GA aggregates impair nuclear import of a reporter containing the TDP-43 nuclear localisation signal.</div> <div itemprodp="datePublished">Wed Feb 15 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27798115"> <div itemprop="name">Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Shin JY,Méndez-López I,Hong M,Wang Y,Tanji K,Wu W,Shugol L,Krauss RS,Dauer WT,Worman HJ</div> <div itemprop="description">AM4300 was used in Western Blotting to explore the potential role of lamina-associated polypeptide 1 in myogenic differentiation and development.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28398475"> <div itemprop="name">Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Li L,Zang L,Zhang F,Chen J,Shen H,Shu L,Liang F,Feng C,Chen D,Tao H,Xu T,Li Z,Kang Y,Wu H,Tang L,Zhang P,Jin P,Shu Q,Li X</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of fat mass and obesity-associated gene in neurodevelopment and neurogenesis.</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28973305"> <div itemprop="name">Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice.</div> </a> <div itemprop="about">Endocrinology</div> <div itemprop="author">Agarwal AK,Tunison K,Dalal JS,Nagamma SS,Hamra FK,Sankella S,Shao X,Auchus RJ,Garg A</div> <div itemprop="description">AM4300 was used in Western Blotting to explore the physiology of 1-acylglycerol-3-phosphate O-acyltransferase in mice.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27984090"> <div itemprop="name">RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.</div> </a> <div itemprop="about">Biochimica et biophysica acta. Molecular cell research</div> <div itemprop="author">Fettweis G,Di Valentin E,L'homme L,Lassence C,Dequiedt F,Fillet M,Coupienne I,Piette J</div> <div itemprop="description">AM4300 was used in Western Blotting to highlight a new role of TSC2 to protect glioblastoma against PDT-induced cell death and (ii) TSC2 and 14-3-3 as new RIP3 partners.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28649090"> <div itemprop="name">MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production.</div> </a> <div itemprop="about">The Journal of endocrinology</div> <div itemprop="author">Zhang L,Zhang X,Zhang X,Lu Y,Li L,Cui S</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that miR-143 plays vital roles in FSH-induced estradiol production and granulosa cell proliferation, providing a novel mechanism that involves miRNA in regulating granulosa cell functions.</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28503576"> <div itemprop="name">Sirtuin 2 Regulates Microvascular Inflammation during Sepsis.</div> </a> <div itemprop="about">Journal of immunology research</div> <div itemprop="author">Buechler N,Wang X,Yoza BK,McCall CE,Vachharajani V</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that SIRT2 modulates microvascular inflammation in sepsis and affects survival.</div> <div itemprodp="datePublished">Thu Feb 08 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29025062"> <div itemprop="name">Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice.</div> </a> <div itemprop="about">Biology of reproduction</div> <div itemprop="author">Zhao J,Zhao J,Xu G,Wang Z,Gao J,Cui S,Liu J</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal the impact of SPATA2 on male fertility and suggested that SPATA2 ensures the normal secretory function of Sertoli cells.</div> <div itemprodp="datePublished">Fri Sep 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28701310"> <div itemprop="name">Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Mamuya FA,Xie D,Lei L,Huang M,Tsuji K,Capen DE,Yang B,Weissleder R,Păunescu TG,Lu HAJ</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effects of Β1-integrin deletion in collecting duct principal cells.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28385289"> <div itemprop="name">Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA.</div> </a> <div itemprop="about">Nutrition research (New York, N.Y.)</div> <div itemprop="author">Martin CR,Stoll B,Cluette-Brown J,Akinkuotu AC,Olutoye OO,Gura KM,Singh P,Zaman MM,Perillo MC,Puder M,Freedman SD,Burrin D</div> <div itemprop="description">AM4300 was used in Western Blotting to evaluate the systemic absorption of a novel enteral Docosahexaenoic acid formulation that forms micelles independent of bile salts.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27929607"> <div itemprop="name">Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.</div> </a> <div itemprop="about">FEBS letters</div> <div itemprop="author">Zhou Z,Menzel F,Benninghoff T,Chadt A,Du C,Holman GD,Al-Hasani H</div> <div itemprop="description">AM4300 was used in Western Blot to study the effect and action of Rab28 in the insulin-stimulated translocation of GLUT4.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28946006"> <div itemprop="name">Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus.</div> </a> <div itemprop="about">Virology</div> <div itemprop="author">Iwahori S,Kalejta RF</div> <div itemprop="description">AM4300 was used in Western Blotting to observe that UL97 phosphorylates LIN52, a component of p107- and p130-assembled transcriptionally repressive DREAM complexes that control transcription during the G0/G1 phases, and the Rb-associated E2F3 protein that activates transcription through G1 and S phases.</div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31719871"> <div itemprop="name">Data-Modeling Identifies Conflicting Signaling Axes Governing Myoblast Proliferation and Differentiation Responses to Diverse Ligand Stimuli.</div> </a> <div itemprop="about">Cellular and molecular bioengineering</div> <div itemprop="author">Loiben AM,Soueid-Baumgarten S,Kopyto RF,Bhattacharya D,Kim JC,Cosgrove BD</div> <div itemprop="description">AM4300 was used in Western Blotting to present an integrated data-modeling approach to elucidate synergies and antagonisms among proliferation and differentiation signaling axes in mouse primary myoblasts stimulated by regeneration-associated ligands.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30090551"> <div itemprop="name">Nanoparticulate titanium dioxide-inhibited dendritic development is involved in apoptosis and autophagy of hippocampal neurons in offspring mice.</div> </a> <div itemprop="about">Toxicology research</div> <div itemprop="author">Zhou Y,Hong F,Tian Y,Zhao X,Hong J,Ze Y,Wang L</div> <div itemprop="description">AM4300 was used in Western Blotting to determine the effects of nanoparticulate titanium dioxide on the dendritic outgrowth of hippocampal neurons, and the excessive apoptosis in neurotoxicity of offspring mice.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28483980"> <div itemprop="name">Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Hötte K,Smyrek I,Starzinski-Powitz A,Stelzer EHK</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest AJAP1 as a novel tumor suppressor and diagnostic marker.</div> <div itemprodp="datePublished">Thu Jun 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28807201"> <div itemprop="name">Overexpression of Thioredoxin1 enhances functional recovery in a mouse model of hind limb ischemia.</div> </a> <div itemprop="about">The Journal of surgical research</div> <div itemprop="author">Shaikh IA,Rishi MT,Youssef M,Selvaraju V,Thirunavukkarasu M,Ukani G,Lakshmanan R,Palesty JA,Maulik N</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that Trx1 enhances blood perfusion and increases angiogenic protein expression in a rodent HLI model.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29093447"> <div itemprop="name">E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Rübsam M,Mertz AF,Kubo A,Marg S,Jüngst C,Goranci-Buzhala G,Schauss AC,Horsley V,Dufresne ER,Moser M,Ziegler W,Amagai M,Wickström SA,Niessen CM</div> <div itemprop="description">AM4300 was used in Western Blotting to study how E-cadherin integrates multiple mechanisms to coordinate the formation of an apical tight junction network.</div> <div itemprodp="datePublished">Wed Nov 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29190822"> <div itemprop="name">The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Janghorban M,Langer EM,Wang X,Zachman D,Daniel CJ,Hooper J,Fleming WH,Agarwal A,Sears RC</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest that B56α is important for stem cells to maintain homeostasis and that B56α loss leads to increased oncogene activity.</div> <div itemprodp="datePublished">Mon Jan 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28955984"> <div itemprop="name">Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter.</div> </a> <div itemprop="about">Biochemistry and biophysics reports</div> <div itemprop="author">Salvi A,Thanabalu T</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that hypoxia-induced activation of N-WASP expression is mediated by HIF1α interaction with the hypoxia response element 1(-132).</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29158493"> <div itemprop="name">Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ikeda H,Sone M,Yamanaka S,Yamamoto T</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that higher-order chromatin regulation may be an integral part of the differentiation capacity that defines pluripotency.</div> <div itemprodp="datePublished">Mon Nov 20 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27818230"> <div itemprop="name">Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.</div> </a> <div itemprop="about">Translational research : the journal of laboratory and clinical medicine</div> <div itemprop="author">Chehaibi K,le Maire L,Bradoni S,Escola JC,Blanco-Vaca F,Slimane MN</div> <div itemprop="description">AM4300 was used in western blot to report the effects of peroxisome proliferator-activated receptor beta/delta agonist on the acute phase response after brain injury</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28967997"> <div itemprop="name">A Detailed Protocol for Subcellular RNA Sequencing (subRNA-seq).</div> </a> <div itemprop="about">Current protocols in molecular biology</div> <div itemprop="author">Mayer A,Churchman LS</div> <div itemprop="description">AM4300 was used in Western Blotting to develop a step-by-step protocol for subcellular RNA-sequencing.</div> <div itemprodp="datePublished">Mon Oct 02 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28627522"> <div itemprop="name">DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Monteagudo S,Cornelis FMF,Aznar-Lopez C,Yibmantasiri P,Guns LA,Carmeliet P,Cailotto F,Lories RJ</div> <div itemprop="description">AM4300 was used in Western Blotting to show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage health.</div> <div itemprodp="datePublished">Mon Jun 19 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29066743"> <div itemprop="name">Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Body S,Esteve-Arenys A,Miloudi H,Recasens-Zorzo C,Tchakarska G,Moros A,Bustany S,Vidal-Crespo A,Rodriguez V,Lavigne R,Com E,Casanova I,Mangues R,Weigert O,Sanjuan-Pla A,Menéndez P,Marcq B,Picquenot JM,Pérez-Galán P,Jardin F,Roué G,Sola B</div> <div itemprop="description">AM4300 was used in Western Blotting to identify a role of cytoplasmic cyclin D1 in the control of mantle cell lymphoma (MCL) cell migration and invasion, and as a true operator of MCL pathogenesis.</div> <div itemprodp="datePublished">Tue Oct 24 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28611249"> <div itemprop="name">A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.</div> </a> <div itemprop="about">mBio</div> <div itemprop="author">Fox HL,Dembowski JA,DeLuca NA</div> <div itemprop="description">AM4300 was used in Western Blot to demonstrate the interaction of a viral protein, ICP22, with a subset of cellular proteins known to be involved in transcription elongation.</div> <div itemprodp="datePublished">Tue Jun 13 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29100390"> <div itemprop="name">FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Vitali E,Boemi I,Rosso L,Cambiaghi V,Novellis P,Mantovani G,Spada A,Alloisio M,Veronesi G,Ferrero S,Lania AG</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that Filamin A is implicated in pulmonary neuroendocrine tumor progression, in part through Rap1.</div> <div itemprodp="datePublished">Fri Sep 29 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28673965"> <div itemprop="name">Accumulation of autophagosomes confers cytotoxicity.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Button RW,Roberts SL,Willis TL,Hanemann CO,Luo S</div> <div itemprop="description">AM4300 was used in Immunocytochemistry to investigate the role of cytotoxicity in accumulating autophagosomes.</div> <div itemprodp="datePublished">Fri Aug 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28330621"> <div itemprop="name">Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Pons-Espinal M,de Luca E,Marzi MJ,Beckervordersandforth R,Armirotti A,Nicassio F,Fabel K,Kempermann G,De Pietri Tonelli D</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that microRNAs are required for the generation of new neurons, but not astrocytes, in the adult murine hippocampus.</div> <div itemprodp="datePublished">Tue Apr 11 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29236713"> <div itemprop="name">Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Hayashi H,Cherpokova D,Martinod K,Witsch T,Wong SL,Gallant M,Cifuni SM,Guarente LP,Wagner DD</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the effect of Sirt3 deficiency on venous thrombosis and NETosis in murine neutrophils and platelets.</div> <div itemprodp="datePublished">Thu Jan 04 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28712848"> <div itemprop="name">A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Jaraíz-Rodríguez M,Tabernero MD,González-Tablas M,Otero A,Orfao A,Medina JM,Tabernero A</div> <div itemprop="description">AM4300 was used in Western Blotting to show that a cell-penetrating peptide inhibited c-Src and focal adhesion kinase, and upregulated phosphatase and tensin homolog in glioma stem cells derived from patients.</div> <div itemprodp="datePublished">Tue Aug 08 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28345603"> <div itemprop="name">PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Faust TB,Li Y,Jang GM,Johnson JR,Yang S,Weiss A,Krogan NJ,Frankel AD</div> <div itemprop="description">AM4300 was used in Western Blotting to describe a candidate RNAi screen of previously identified high-confidence Tat interacting proteins and report that several proteins from ubiquitin signalling pathways are essential for Tat activity.</div> <div itemprodp="datePublished">Mon Mar 27 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28195124"> <div itemprop="name">Pervasive translational regulation of the cell signalling circuitry underlies mammalian development.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Fujii K,Shi Z,Zhulyn O,Denans N,Barna M</div> <div itemprop="description">AM4300 was used in Western Blotting to monitor translation of the mammalian genome as cells become specified and organize into tissues in vivo.</div> <div itemprodp="datePublished">Tue Feb 14 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28772050"> <div itemprop="name">The neuroprotective agent Rasagiline mesylate attenuates cardiac remodeling after experimental myocardial infarction.</div> </a> <div itemprop="about">ESC heart failure</div> <div itemprop="author">Varela A,Mavroidis M,Katsimpoulas M,Sfiroera I,Kappa N,Mesa A,Kostomitsopoulos NG,Cokkinos DV</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate a positive effect of rasagiline mesylate in the post-myocardial infarction period with a significant attenuation in cardiac remodelling.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28289097"> <div itemprop="name">Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Iwahori S,Umaña AC,VanDeusen HR,Kalejta RF</div> <div itemprop="description">AM4300 was used in Western Blotting to identify the retinoblastoma protein-related proteins, p107 and p130, as novel targets of human cytomegalovirus-encoded UL97.</div> <div itemprodp="datePublished">Fri Apr 21 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28733671"> <div itemprop="name">Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Weitkunat K,Stuhlmann C,Postel A,Rumberger S,Fankhänel M,Woting A,Petzke KJ,Gohlke S,Schulz TJ,Blaut M,Klaus S,Schumann S</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate how various types of dietary fibre and different short-chain fatty acid ratios affect metabolic syndrome-related disorders.</div> <div itemprodp="datePublished">Fri Jul 21 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28552582"> <div itemprop="name">Proteasome Activation by Small Molecules.</div> </a> <div itemprop="about">Cell chemical biology</div> <div itemprop="author">Leestemaker Y,de Jong A,Witting KF,Penning R,Schuurman K,Rodenko B,Zaal EA,van de Kooij B,Laufer S,Heck AJR,Borst J,Scheper W,Berkers CR,Ovaa H</div> <div itemprop="description">AM4300 was used in SDS-PAGE to study the activation of 26S proteasome activity and how this can be achieved through multiple mechanisms by distinct molecules.</div> <div itemprodp="datePublished">Thu Jun 22 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29062910"> <div itemprop="name">Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response.</div> </a> <div itemprop="about">Wellcome open research</div> <div itemprop="author">Chalmers F,van Lith M,Sweeney B,Cain K,Bulleid NJ</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that a feedback mechanism exists to attenuate inositol requiring enzyme α ribonuclease activity in the presence of X-box binding protein 1.</div> <div itemprodp="datePublished">Sat Jan 29 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28194447"> <div itemprop="name">G<b>α</b><sub>11</sub> mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Gorvin CM,Hannan FM,Howles SA,Babinsky VN,Piret SE,Rogers A,Freidin AJ,Stewart M,Paudyal A,Hough TA,Nesbit MA,Wells S,Vincent TL,Brown SD,Cox RD,Thakker RV</div> <div itemprop="description">AM4300 was used in Western Blotting to establish Dsk7 mice, which harbor a germline gain-of-function Gα11 mutation, as a model for ADH2 and demonstrate calcilytics as a potential targeted therapy.</div> <div itemprodp="datePublished">Thu Feb 09 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28174228"> <div itemprop="name">Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes.</div> </a> <div itemprop="about">Molecular & cellular proteomics : MCP</div> <div itemprop="author">Shah M,Smolko CM,Kinicki S,Chapman ZD,Brautigan DL,Janes KA</div> <div itemprop="description">AM4300 was used in Western Blotting to introduce a generalised functional assay for high-throughput profiling of multiple protein phosphatases.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27920203"> <div itemprop="name">A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Bloch N,Gläsker S,Sitaram P,Hofmann H,Shepard CN,Schultz ML,Kim B,Landau NR</div> <div itemprop="description">AM4300 was used in Western Blotting to characterise the biochemical and antiviral properties of the two mouse isoforms of SAMHD1 (sterile α motif and histidine-aspartate domain-containing protein 1).</div> <div itemprodp="datePublished">Fri Jan 20 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29047414"> <div itemprop="name">Histone isoform H2A1H promotes attainment of distinct physiological states by altering chromatin dynamics.</div> </a> <div itemprop="about">Epigenetics & chromatin</div> <div itemprop="author">Bhattacharya S,Reddy D,Jani V,Gadewal N,Shah S,Reddy R,Bose K,Sonavane U,Joshi R,Smoot D,Ashktorab H,Gupta S</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the specific functional contribution of the histone H2A isoform H2A1H.</div> <div itemprodp="datePublished">Wed Oct 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29254146"> <div itemprop="name">cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Padmanabhan C,Rellinger EJ,Zhu J,An H,Woodbury LG,Chung DH,Waterson AG,Lindsley CW,Means AL,Beauchamp RD</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that ML327 reverses much of the epithelial-to-mesenchymal transition gene expression programme in cultured carcinoma cell lines.</div> <div itemprodp="datePublished">Fri Nov 24 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31548538"> <div itemprop="name">Modulation of BCR Signaling by the Induced Dimerization of Receptor-Associated SYK.</div> </a> <div itemprop="about">Antibodies (Basel, Switzerland)</div> <div itemprop="author">Westbroek ML,Geahlen RL</div> <div itemprop="description">AM4300 was used in Western Blotting to explore factors that modulate the quantity and quality of signals sent by the crosslinked B cell antigen receptor (BCR), by developing a novel chemical mediator of dimerization to induce clustering of receptor-associated SYK.</div> <div itemprodp="datePublished">Thu Dec 07 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27798611"> <div itemprop="name">Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.</div> </a> <div itemprop="about">Nature methods</div> <div itemprop="author">Hess GT,Frésard L,Han K,Lee CH,Li A,Cimprich KA,Montgomery SB,Bassik MC</div> <div itemprop="description">AM4300 was used in Western Blotting to develop CRISPR-X, a strategy to repurpose the somatic hypermutation machinery for protein engineering in situ.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27836432"> <div itemprop="name">Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Varga T,Mounier R,Patsalos A,Gogolák P,Peloquin M,Horvath A,Pap A,Daniel B,Nagy G,Pintye E,Póliska S,Cuvellier S,Larbi SB,Sansbury BE,Spite M,Brown CW,Chazaud B,Nagy L</div> <div itemprop="description">AM4300 was used in Western Blotting to show that the lipid activated transcription factor, PPARγ, is required for proper skeletal muscle regeneration, acting in repair macrophages.</div> <div itemprodp="datePublished">Tue Nov 15 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26673800"> <div itemprop="name">A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer.</div> </a> <div itemprop="about">Clinical cancer research : an official journal of the American Association for Cancer Research</div> <div itemprop="author">Drilon A,Somwar R,Wagner JP,Vellore NA,Eide CA,Zabriskie MS,Arcila ME,Hechtman JF,Wang L,Smith RS,Kris MG,Riely GJ,Druker BJ,O'Hare T,Ladanyi M,Davare MA</div> <div itemprop="description">AM4300 was used in western blot to study a novel crizotinib-resistant solvent-front mutation in a patient with ROS1-rearranged lung cancer that is responsive to cabozantinib therapy</div> <div itemprodp="datePublished">Sun May 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26363554"> <div itemprop="name">TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.</div> </a> <div itemprop="about">Cellular and molecular life sciences : CMLS</div> <div itemprop="author">Suzuki M,Watanabe M,Nakamaru Y,Takagi D,Takahashi H,Fukuda S,Hatakeyama S</div> <div itemprop="description">AM4300 was used in western blot to assess negative regulation of the NF-kappaB-mediated signaling pathway through stabilization of Cactin by TRIM39</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26973240"> <div itemprop="name">Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">German P,Bai S,Liu XD,Sun M,Zhou L,Kalra S,Zhang X,Minelli R,Scott KL,Mills GB,Jonasch E,Ding Z</div> <div itemprop="description">AM4300 was used in western blot to determine the regulation of von Hippel Lindau proteostasis and function by phosphorylation-dependent cleavage</div> <div itemprodp="datePublished">Thu Sep 22 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27064541"> <div itemprop="name">Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance.</div> </a> <div itemprop="about">American journal of respiratory cell and molecular biology</div> <div itemprop="author">Flodby P,Kim YH,Beard LL,Gao D,Ji Y,Kage H,Liebler JM,Minoo P,Kim KJ,Borok Z,Crandall ED</div> <div itemprop="description">AM4300 was used in western blot to determine the major role for alveolar epithelial type 1 cells in alveolar fluid clearance revealed by knockout mice</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26875662"> <div itemprop="name">Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures.</div> </a> <div itemprop="about">Neurobiology of disease</div> <div itemprop="author">Awad PN,Sanon NT,Chattopadhyaya B,Carriço JN,Ouardouz M,Gagné J,Duss S,Wolf D,Desgent S,Cancedda L,Carmant L,Di Cristo G</div> <div itemprop="description">AM4300 was used in western blot to investigate the rescue of seizure susceptibility and spine morphology in atypical febrile seizures by reducing premature KCC2 expression</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27512069"> <div itemprop="name">Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Lee SH,Caviness K,Albright ER,Lee JH,Gelbmann CB,Rak M,Goodrum F,Kalejta RF</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that short and long isoforms of UL138 exist and can support latency, perhaps in temporally distinct manners.</div> <div itemprodp="datePublished">Sat Oct 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26733502"> <div itemprop="name">Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours.</div> </a> <div itemprop="about">Endocrine-related cancer</div> <div itemprop="author">Vitali E,Cambiaghi V,Zerbi A,Carnaghi C,Colombo P,Peverelli E,Spada A,Mantovani G,Lania AG</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that Filamin A plays a crucial role in somatostatin receptor type 2 expression, signalling, angiogenesis, cell adhesion and migration in pancreatic neuroendocrine tumours.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27089993"> <div itemprop="name">Tbc1d1 deletion suppresses obesity in leptin-deficient mice.</div> </a> <div itemprop="about">International journal of obesity (2005)</div> <div itemprop="author">Dokas J,Chadt A,Joost HG,Al-Hasani H</div> <div itemprop="description">AM4300 was used in western blot to research suppression of obesity in leptin-deficient mice by Tbc1d1 deletion</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26866974"> <div itemprop="name">Diacylglycerol pyrophosphate binds and inhibits the glyceraldehyde-3-phosphate dehydrogenase in barley aleurone.</div> </a> <div itemprop="about">Plant physiology and biochemistry : PPB</div> <div itemprop="author">Astorquiza PL,Usorach J,Racagni G,Villasuso AL</div> <div itemprop="description">AM4300 was used in western blot to characterize inhibition and binding of the glyceraldehyde-3-phosphate dehydrogenase in barley aleurone due to diacylglycerol pyrophosphate</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27694492"> <div itemprop="name">Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Alphonse MP,Duong TT,Shumitzu C,Hoang TL,McCrindle BW,Franco A,Schurmans S,Philpott DJ,Hibberd ML,Burns J,Kuijpers TW,Yeung RS</div> <div itemprop="description">AM4300 was used in western blot to discuss the contribution of IL-1beta and NLRP3 inflammasome activation to Kawasaki disease</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27034136"> <div itemprop="name">A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Wang Y,Lichter-Konecki U,Anyane-Yeboa K,Shaw JE,Lu JT,Östlund C,Shin JY,Clark LN,Gundersen GG,Nagy PL,Worman HJ</div> <div itemprop="description">AM4300 was used in western blot to study the cause of progeroid disorder by a mutation abolishing the ZMPSTE24 cleavage site in prelamin A</div> <div itemprodp="datePublished">Sun May 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27084580"> <div itemprop="name">ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Feng L,Wang Y,Cai H,Sun G,Niu W,Xin Q,Tang X,Zhang J,Wang C,Zhang H,Xia G</div> <div itemprop="description">AM4300 was used in western blot to assess the governing of the recruitment of ovarian pregranulosa cells and control of folliculogenesis in mice due to ADAM10-Notch signaling</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28217037"> <div itemprop="name">Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism.</div> </a> <div itemprop="about">Metabolomics : Official journal of the Metabolomic Society</div> <div itemprop="author">Files DC,Ilaiwy A,Parry TL,Gibbs KW,Liu C,Bain JR,Delbono O,Muehlbauer MJ,Willis MS</div> <div itemprop="description">AM4300 was used in Western Blotting to develop a model of lung injury-induced muscle wasting in old mice and to evaluate the skeletal muscle metabolomic profile of adult and old acute lung injury mice.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26061116"> <div itemprop="name">The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Ronchi G,Haastert-Talini K,Fornasari BE,Perroteau I,Geuna S,Gambarotta G</div> <div itemprop="description">AM4300 was used in western blot to study the role of Neuregulin1/ErbB system during peripheral nerve degeneration and regeneration</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27600876"> <div itemprop="name">Sp1 downregulates proinflammatory cytokine‑induced catabolic gene expression in nucleus pulposus cells.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Xu K,Wang X,Zhang Q,Liang A,Zhu H,Huang D,Li C,Ye W</div> <div itemprop="description">AM4300 was used in Western Blotting to examine the importance of specificity protein-1 in catabolic enzyme gene regulation during TNF-α stimulation.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27554763"> <div itemprop="name">Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.</div> </a> <div itemprop="about">Cancer prevention research (Philadelphia, Pa.)</div> <div itemprop="author">Boutaud O,Sosa IR,Amin T,Oram D,Adler D,Hwang HS,Crews BC,Milne G,Harris BK,Hoeksema M,Knollmann BC,Lammers PE,Marnett LJ,Massion PP,Oates JA</div> <div itemprop="description">AM4300 was used in Western Blotting to study whether low-dose aspirin inhibits prostaglandin E2 biosynthesis, and the implications this has in adenocarcinoma metastasis.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26678504"> <div itemprop="name">Novel subcellular localization of the DNA helicase Twinkle at the kinetochore complex during mitosis in neuronal-like progenitor cells.</div> </a> <div itemprop="about">Histochemistry and cell biology</div> <div itemprop="author">Uittenbogaard M,Chiaramello A</div> <div itemprop="description">AM4300 was used in Western Blotting to study the expression of DNA helicase, Twinkle, during chromosomal segregation at distinct mitotic phases.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26822143"> <div itemprop="name">Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors.</div> </a> <div itemprop="about">Organic & biomolecular chemistry</div> <div itemprop="author">De Vreese R,Depetter Y,Verhaeghe T,Desmet T,Benoy V,Haeck W,Van Den Bosch L,D'hooghe M</div> <div itemprop="description">AM4300 was used in Western Blotting to reveal hydroxamic acids can be recognized as lead structures for novel potent and selective HDAC6 inhibitors.</div> <div itemprodp="datePublished">Sun Feb 28 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27698495"> <div itemprop="name">The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Zee BM,Dibona AB,Alekseyenko AA,French CA,Kuroda MI</div> <div itemprop="description">AM4300 was used in Western Blotting to postulate that BRD4-NUT complexes override the preexisting histone code with new posttranslational modifications patterns that reflect aberrant transcription.</div> <div itemprodp="datePublished">Tue Jun 27 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27058625"> <div itemprop="name">Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Shi G,Yoshida Y,Yuki K,Nishimura T,Kawata Y,Kawashima M,Iwaisako K,Yoshikawa K,Kurebayashi J,Toi M,Noda M</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate the value of combined use of two RECK methylation markers for predicting prognosis and drug-sensitivity of breast cancers.</div> <div itemprodp="datePublished">Tue Dec 13 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26586915"> <div itemprop="name">Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Nouws J,Goswami AV,Bestwick M,McCann BJ,Surovtseva YV,Shadel GS</div> <div itemprop="description">AM4300 was used in western blot to determine the requirement of mitochondrial ribosomal protein L12 for POLRMT stability and exists as two forms generated by alternative proteolysis during import</div> <div itemprodp="datePublished">Fri Jan 08 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27032383"> <div itemprop="name">PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Ledsaak M,Bengtsen M,Molværsmyr AK,Fuglerud BM,Matre V,Eskeland R,Gabrielsen OS</div> <div itemprop="description">AM4300 was used in western blot to analyze the binding of p300 with PIAS1 acting as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27613867"> <div itemprop="name">Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Maganti AV,Tersey SA,Syed F,Nelson JB,Colvin SC,Maier B,Mirmira RG</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that PPAR-γ activation directly improves Β cell function and survival in non-obese diabetic mice.</div> <div itemprodp="datePublished">Fri Oct 21 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27085973"> <div itemprop="name">Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Huang CJ,Lee CL,Yang SH,Chien CC,Huang CC,Yang RN,Chang CC</div> <div itemprop="description">AM4300 was used in western blot to study growth arrest-specific-2 upregulation in recurrent colorectal cancer and its susceptibility to chemotherapy in a model cell system</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27428424"> <div itemprop="name">Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Illendula A,Gilmour J,Grembecka J,Tirumala VSS,Boulton A,Kuntimaddi A,Schmidt C,Wang L,Pulikkan JA,Zong H,Parlak M,Kuscu C,Pickin A,Zhou Y,Gao Y,Mishra L,Adli M,Castilla LH,Rajewski RA,Janes KA,Guzman ML,Bonifer C,Bushweller JH</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate whether targeting RUNX proteins could have broad utility in cancer therapeutics.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26369756"> <div itemprop="name">Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling.</div> </a> <div itemprop="about">Journal of cellular biochemistry</div> <div itemprop="author">Carthy JM,Engström U,Heldin CH,Moustakas A</div> <div itemprop="description">AM4300 was used in Immunocytochemistry, Western Blot to find that treatment of cultured fibroblasts with recombinant Wnt3a induced immediate activation of TGF-β and BMP signaling and this activity appeared to be independent of the Wnt ligand itself.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26520123"> <div itemprop="name">Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">Valcourt U,Carthy J,Okita Y,Alcaraz L,Kato M,Thuault S,Bartholin L,Moustakas A</div> <div itemprop="description">AM4300 was used in western blot to analyze the transition from epithelial-mesenchymal induced by transforming growth factor beta</div> <div itemprodp="datePublished">Tue May 24 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27321931"> <div itemprop="name">Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Muñoz-Félix JM,Pérez-Roque L,Núñez-Gómez E,Oujo B,Arévalo M,Ruiz-Remolina L,Cuesta C,Langa C,Pérez-Barriocanal F,Bernabeu C,Lopez-Novoa JM</div> <div itemprop="description">AM4300 was used in western blot to analyze the reduction of renal fibrosis and inflammation after unilateral ureteral obstruction due to overexpression of the short endoglin isoform</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27657532"> <div itemprop="name">Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kim YK,Yadava RS,Mandal M,Mahadevan K,Yu Q,Leitges M,Mahadevan MS</div> <div itemprop="description">AM4300 was used in western blot to clarify the role of protein kinase C in the pathogenesis of RNA toxicity</div> <div itemprodp="datePublished">Wed Nov 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27011052"> <div itemprop="name">Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Del Debbio CB,Mir Q,Parameswaran S,Mathews S,Xia X,Zheng L,Neville AJ,Ahmad I</div> <div itemprop="description">AM4300 was used in western blot to study how transcriptional regulation and Skp2-mediated degradation of p27Kip1 activates stem cell properties of muller glia through notch signaling</div> <div itemprodp="datePublished">Thu Aug 11 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27510168"> <div itemprop="name">The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Batalha VL,Ferreira DG,Coelho JE,Valadas JS,Gomes R,Temido-Ferreira M,Shmidt T,Baqi Y,Buée L,Müller CE,Hamdane M,Outeiro TF,Bader M,Meijsing SH,Sadri-Vakili G,Blum D,Lopes LV</div> <div itemprop="description">AM4300 was used in western blot show that A2AR regulates GR function and contributes to age-related memory deficits</div> <div itemprodp="datePublished">Thu Aug 11 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25642965"> <div itemprop="name">Mitochondrial DNA stress primes the antiviral innate immune response.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">West AP,Khoury-Hanold W,Staron M,Tal MC,Pineda CM,Lang SM,Bestwick M,Duguay BA,Raimundo N,MacDuff DA,Kaech SM,Smiley JR,Means RE,Iwasaki A,Shadel GS</div> <div itemprop="description">AM4300 was used in western blot to analyze the antiviral innate immune response due to mitochondrial DNA stress</div> <div itemprodp="datePublished">Thu Apr 23 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25910208"> <div itemprop="name">Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Mayer A,di Iulio J,Maleri S,Eser U,Vierstra J,Reynolds A,Sandstrom R,Stamatoyannopoulos JA,Churchman LS</div> <div itemprop="description">AM4300 was used in western blot to use native elongating transcript sequencing in human cells to globally map strand-specific RNA polymerase II density at nucleotide resolution</div> <div itemprodp="datePublished">Thu Apr 23 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25888330"> <div itemprop="name">Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.</div> </a> <div itemprop="about">Gastroenterology</div> <div itemprop="author">Bettaieb A,Jiang JX,Sasaki Y,Chao TI,Kiss Z,Chen X,Tian J,Katsuyama M,Yabe-Nishimura C,Xi Y,Szyndralewiez C,Schröder K,Shah A,Brandes RP,Haj FG,Török NJ</div> <div itemprop="description">AM4300 was used in western blot to investigate the effects of nicotinamide adenine dinucleotide phosphate reduced oxidase 4 in liver tissues from patients with NASH and mice with steatohepatitis.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26330466"> <div itemprop="name">Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Emde A,Eitan C,Liou LL,Libby RT,Rivkin N,Magen I,Reichenstein I,Oppenheim H,Eilam R,Silvestroni A,Alajajian B,Ben-Dov IZ,Aebischer J,Savidor A,Levin Y,Sons R,Hammond SM,Ravits JM,Möller T,Hornstein E</div> <div itemprop="description">AM4300 was used in Western Blotting to show that extensive down-regulation of miRNA levels is a common molecular denominator for multiple forms of human amyotrophic lateral sclerosis.</div> <div itemprodp="datePublished">Tue Nov 03 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26372962"> <div itemprop="name">Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Davare MA,Vellore NA,Wagner JP,Eide CA,Goodman JR,Drilon A,Deininger MW,O'Hare T,Druker BJ</div> <div itemprop="description">AM4300 was used in western blot to discuss the sensitivity and selectivity of seven ROS and/or ALK inhibitors.</div> <div itemprodp="datePublished">Tue Sep 29 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25652038"> <div itemprop="name">Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Schreiber KH,Ortiz D,Academia EC,Anies AC,Liao CY,Kennedy BK</div> <div itemprop="description">AM4300 was used in western blot to show that FKBP12 and FKBP51 levels determine the responsiveness of a cell line or tissue to rapamycin.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25852189"> <div itemprop="name">An analysis of critical factors for quantitative immunoblotting.</div> </a> <div itemprop="about">Science signaling</div> <div itemprop="author">Janes KA</div> <div itemprop="description">AM4300 was used in western blot to examine an immunoblot-analysis workflow for accuracy and precision</div> <div itemprodp="datePublished">Tue Apr 07 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25381817"> <div itemprop="name">Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Shriver M,Stroka KM,Vitolo MI,Martin S,Huso DL,Konstantopoulos K,Kontrogianni-Konstantopoulos A</div> <div itemprop="description">AM4300 was used in western blot to identify the role of obscurins during breast carcinogenesis</div> <div itemprodp="datePublished">Thu Aug 06 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25109331"> <div itemprop="name">Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Riemer P,Sreekumar A,Reinke S,Rad R,Schäfer R,Sers C,Bläker H,Herrmann BG,Morkel M</div> <div itemprop="description">AM4300 was used in western blot to investigate how BRAF/MAPK activity regulates intestinal stem cell populations and contributes to colon cancer.</div> <div itemprodp="datePublished">Thu Jun 11 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26244496"> <div itemprop="name">An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Schreiber CA,Sakuma T,Izumiya Y,Holditch SJ,Hickey RD,Bressin RK,Basu U,Koide K,Asokan A,Ikeda Y</div> <div itemprop="description">AM4300 was used in Western Blotting to identify host factors that might affect the key steps in adeno-associated virus infection.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26018171"> <div itemprop="name">Functional Analysis of the 60-Nucleotide Duplication in the Respiratory Syncytial Virus Buenos Aires Strain Attachment Glycoprotein.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Hotard AL,Laikhter E,Brooks K,Hartert TV,Moore ML</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate whether the duplicated region in the glycoprotein gene (G) serves to enhance the function of G in the virus life cycle.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25339762"> <div itemprop="name">Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Hotard AL,Lee S,Currier MG,Crowe JE,Sakamoto K,Newcomb DC,Peebles RS,Plemper RK,Moore ML</div> <div itemprop="description">AM4300 was used in Western Blotting to establish the role of RSV F in virulence.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26096876"> <div itemprop="name">Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Carthy JM,Sundqvist A,Heldin A,van Dam H,Kletsas D,Heldin CH,Moustakas A</div> <div itemprop="description">AM4300 was used in western blot to show that tamoxifen prevents myofibroblast differentiation.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25407900"> <div itemprop="name">MiR-497∼195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Grünhagen J,Bhushan R,Degenkolbe E,Jäger M,Knaus P,Mundlos S,Robinson PN,Ott CE</div> <div itemprop="description">AM4300 was used in western blot to study microRNAs in bone development.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25885945"> <div itemprop="name">Parathyroid Hormone-Related Protein, Human Adipose-Derived Stem Cells Adipogenic Capacity and Healthy Obesity.</div> </a> <div itemprop="about">The Journal of clinical endocrinology and metabolism</div> <div itemprop="author">Roca-Rodríguez MM,El Bekay R,Garrido-Sanchez L,Gómez-Serrano M,Coin-Aragüez L,Oliva-Olivera W,Lhamyani S,Clemente-Postigo M,García-Santos E,de Luna Diaz R,Yubero-Serrano EM,Fernández Real JM,Peral B,Tinahones FJ</div> <div itemprop="description">AM4300 was used in western blot to test if PTHrP contributes to adipogenic regulation, obesity, and insulin resistance.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25885945"> <div itemprop="name">Parathyroid Hormone-Related Protein, Human Adipose-Derived Stem Cells Adipogenic Capacity and Healthy Obesity.</div> </a> <div itemprop="about">The Journal of clinical endocrinology and metabolism</div> <div itemprop="author">Roca-Rodríguez MM,El Bekay R,Garrido-Sanchez L,Gómez-Serrano M,Coin-Aragüez L,Oliva-Olivera W,Lhamyani S,Clemente-Postigo M,García-Santos E,de Luna Diaz R,Yubero-Serrano EM,Fernández Real JM,Peral B,Tinahones FJ</div> <div itemprop="description">AM4300 was used in western blot to test if PTHrP contributes to adipogenic regulation, obesity, and insulin resistance.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26684871"> <div itemprop="name">Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen.</div> </a> <div itemprop="about">Arthritis research & therapy</div> <div itemprop="author">Blachère NE,Parveen S,Fak J,Frank MO,Orange DE</div> <div itemprop="description">AM4300 was used in western blot to test if dying neutrophils release peptidyl arginine deiminase, which results in citrullination of antigens relevant to rheumatoid arthritis</div> <div itemprodp="datePublished">Thu Dec 17 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26189946"> <div itemprop="name">A Dual SILAC Proteomic Labeling Strategy for Quantifying Constitutive and Cell-Cell Induced Protein Secretion.</div> </a> <div itemprop="about">Journal of proteome research</div> <div itemprop="author">Stiess M,Wegehingel S,Nguyen C,Nickel W,Bradke F,Cambridge SB</div> <div itemprop="description">AM4300 was used in western blot to describe a strategy of dual SILAC labeling astrocytic cultures for in silico exclusion of unlabeled proteins from serum or neurons used for stimulation.</div> <div itemprodp="datePublished">Fri Aug 07 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24916641"> <div itemprop="name">Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome.</div> </a> <div itemprop="about">European journal of human genetics : EJHG</div> <div itemprop="author">Kolanczyk M,Krawitz P,Hecht J,Hupalowska A,Miaczynska M,Marschner K,Schlack C,Emmerich D,Kobus K,Kornak U,Robinson PN,Plecko B,Grangl G,Uhrig S,Mundlos S,Horn D</div> <div itemprop="description">AM4300 was used in western blot to identify a hypomorphic variant of CCDC22 in patients with RSS/3C syndrome in an Austrian family</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25967552"> <div itemprop="name">The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Reales E,Bernabé-Rubio M,Casares-Arias J,Rentero C,Fernández-Barrera J,Rangel L,Correas I,Enrich C,Andrés G,Alonso MA</div> <div itemprop="description">AM4300 was used in immunocytochemistry to study the role of MAL, a tetraspanning protein, in primary cilium formation</div> <div itemprodp="datePublished">Mon Jun 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25825523"> <div itemprop="name">Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Tsukiyama T,Fukui A,Terai S,Fujioka Y,Shinada K,Takahashi H,Yamaguchi TP,Ohba Y,Hatakeyama S</div> <div itemprop="description">AM4300 was used in Western blotting following immunoprecipitation to demonstrate that RNF43 suppresses both Wnt/Β-catenin signalling and noncanonical Wnt signalling by distinct mechanisms.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25825523"> <div itemprop="name">Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Tsukiyama T,Fukui A,Terai S,Fujioka Y,Shinada K,Takahashi H,Yamaguchi TP,Ohba Y,Hatakeyama S</div> <div itemprop="description">AM4300 was used in Western blotting following immunoprecipitation to demonstrate that RNF43 suppresses both Wnt/Β-catenin signalling and noncanonical Wnt signalling by distinct mechanisms.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25421809"> <div itemprop="name">Loss of auditory activity modifies the location of potassium channel KCNQ5 in auditory brainstem neurons.</div> </a> <div itemprop="about">Journal of neuroscience research</div> <div itemprop="author">Caminos E,Garcia-Pino E,Juiz JM</div> <div itemprop="description">AM4300 was used in western blot to analyze the modification of the location of potassium channel KCNQ5 in auditory brainstem neurons due to loss of auditory activity</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25908446"> <div itemprop="name">Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle.</div> </a> <div itemprop="about">Muscle & nerve</div> <div itemprop="author">Ljubicic V,Jasmin BJ</div> <div itemprop="description">AM4300 was used in western blot to identify the mechanism of metformin on dystrophic muscle</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24700450"> <div itemprop="name">CD200: association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma.</div> </a> <div itemprop="about">Head & neck</div> <div itemprop="author">Jung YS,Vermeer PD,Vermeer DW,Lee SJ,Goh AR,Ahn HJ,Lee JH</div> <div itemprop="description">AM4300 was used in western blot to correlate the expression of CD200 in various types of cancer with the responses to chemotherapy and radiation.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24057454"> <div itemprop="name">Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.</div> </a> <div itemprop="about">Brain structure & function</div> <div itemprop="author">Kröcher T,Malinovskaja K,Jürgenson M,Aonurm-Helm A,Zharkovskaya T,Kalda A,Röckle I,Schiff M,Weinhold B,Gerardy-Schahn R,Hildebrandt H,Zharkovsky A</div> <div itemprop="description">AM4300 was used in western blot to test if polyST deficiency results in a schizophrenia-like phenotype using knock out mice.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26341910"> <div itemprop="name">Identification of intellectual disability genes showing circadian clock-dependent expression in the mouse hippocampus.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Renaud J,Dumont F,Khelfaoui M,Foisset SR,Letourneur F,Bienvenu T,Khwaja O,Dorseuil O,Billuart P</div> <div itemprop="description">AM4300 was used in western blot to study the rhythmic expression of intellectual disability genes in the mouse hippocampus</div> <div itemprodp="datePublished">Thu Nov 12 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26433703"> <div itemprop="name">FOXG1 expression shows correlation with neuronal differentiation in cerebellar development, aggressive phenotype in medulloblastomas, and survival in a xenograft model of medulloblastoma.</div> </a> <div itemprop="about">Human pathology</div> <div itemprop="author">Adesina AM,Veo BL,Courteau G,Mehta V,Wu X,Pang K,Liu Z,Li XN,Peters L</div> <div itemprop="description">AM4300 was used in western blot to investigate the role of FOXG1 in neuronal differentiation.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26546975"> <div itemprop="name">CRISPR/Cas9: An inexpensive, efficient loss of function tool to screen human disease genes in Xenopus.</div> </a> <div itemprop="about">Developmental biology</div> <div itemprop="author">Bhattacharya D,Marfo CA,Li D,Lane M,Khokha MK</div> <div itemprop="description">AM4300 was used in Western Blotting to utilise CRISPR based F0 gene editing in Xenopus tropicalis for human congenital malformation candidate gene screening.</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25312837"> <div itemprop="name">Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo.</div> </a> <div itemprop="about">Journal of orthopaedic research : official publication of the Orthopaedic Research Society</div> <div itemprop="author">Otabe K,Nakahara H,Hasegawa A,Matsukawa T,Ayabe F,Onizuka N,Inui M,Takada S,Ito Y,Sekiya I,Muneta T,Lotz M,Asahara H</div> <div itemprop="description">AM4300 was used in western blot to determine the role of mohawk homeobox in ligament/tenogenic differentiation of bone marrow derived mesenchymal stem cells</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25925610"> <div itemprop="name">Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices.</div> </a> <div itemprop="about">Cell structure and function</div> <div itemprop="author">Iguchi Y,Ishihara S,Uchida Y,Tajima K,Mizutani T,Kawabata K,Haga H</div> <div itemprop="description">AM4300 was used in western blot to study the contribution of filamin B on the invasiveness of cancer.</div> <div itemprodp="datePublished">Mon Apr 04 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25326774"> <div itemprop="name">Analysis of human papillomavirus E7 protein status in C-33A cervical cancer cells.</div> </a> <div itemprop="about">Virus genes</div> <div itemprop="author">Kaiser A,Jenewein B,Pircher H,Rostek U,Jansen-Dürr P,Zwerschke W</div> <div itemprop="description">AM4300 was used in western blot to examine expression of the E7 protein in cervical cancer cell lines</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26071105"> <div itemprop="name">TRIM29 regulates the p63-mediated pathway in cervical cancer cells.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Masuda Y,Takahashi H,Hatakeyama S</div> <div itemprop="description">AM4300 was used in western blot to demonstrate that TRIM29 regulates the p63 pathway in cervical cancer cells</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26095369"> <div itemprop="name">TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Masuda Y,Takahashi H,Sato S,Tomomori-Sato C,Saraf A,Washburn MP,Florens L,Conaway RC,Conaway JW,Hatakeyama S</div> <div itemprop="description">AM4300 was used in western blot to elucidate the function of TRIM29 in double stranded break repair.</div> <div itemprodp="datePublished">Mon Jun 22 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26429917"> <div itemprop="name">Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Krisenko MO,Higgins RL,Ghosh S,Zhou Q,Trybula JS,Wang WH,Geahlen RL</div> <div itemprop="description">AM4300 was used in western blot to show that Grb7 recruits Syk to the stress granule.</div> <div itemprodp="datePublished">Fri Nov 13 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26694420"> <div itemprop="name">MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways.</div> </a> <div itemprop="about">Marine drugs</div> <div itemprop="author">Hasan I,Sugawara S,Fujii Y,Koide Y,Terada D,Iimura N,Fujiwara T,Takahashi KG,Kojima N,Rajia S,Kawsar SM,Kanaly RA,Uchiyama H,Hosono M,Ogawa Y,Fujita H,Hamako J,Matsui T,Ozeki Y</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that the novel R-type lectin MytiLec initiates programmed cell death of Burkitt's lymphoma cells through multiple pathways based on interaction of the lectin with Gb3-containing glycosphingolipid-enriched microdomains on the cell surface.</div> <div itemprodp="datePublished">Mon Dec 14 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26051938"> <div itemprop="name">Aurora Kinase B Regulates Telomerase Activity via a Centromeric RNA in Stem Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Mallm JP,Rippe K</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate in mouse embryonic stem cells, telomere maintenance is regulated via expression of cenRNA in a cell-cycle-dependent manner.</div> <div itemprodp="datePublished">Tue Jun 16 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25429098"> <div itemprop="name">GAPDH and β-actin protein decreases with aging, making Stain-Free technology a superior loading control in Western blotting of human skeletal muscle.</div> </a> <div itemprop="about">Journal of applied physiology (Bethesda, Md. : 1985)</div> <div itemprop="author">Vigelsø A,Dybboe R,Hansen CN,Dela F,Helge JW,Guadalupe Grau A</div> <div itemprop="description">AM4300 was used in western blot to assess the best reference to use as a loading control for Western blotting of human skeletal muscle in applied physiology</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26407333"> <div itemprop="name">Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Seo MY,Jang W,Rhee K</div> <div itemprop="description">AM4300 was used in western blot to study the role of the pericentriolar material disassembly in centriole separation during mitotic exit.</div> <div itemprodp="datePublished">Fri Jun 17 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25765318"> <div itemprop="name">Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Hutchins AP,Takahashi Y,Miranda-Saavedra D</div> <div itemprop="description">AM4300 was used in western blot to investigate the mechanisms downstream of STAT3 signaling that regulate inflammation</div> <div itemprodp="datePublished">Fri Mar 13 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26400081"> <div itemprop="name">Antigen-B Cell Receptor Complexes Associate with Intracellular major histocompatibility complex (MHC) Class II Molecules.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Barroso M,Tucker H,Drake L,Nichol K,Drake JR</div> <div itemprop="description">AM4300 was used in western blot to study molecular mechanisms used by B cells to control the source of peptides loaded onto class II molecules.</div> <div itemprodp="datePublished">Fri Nov 06 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25657004"> <div itemprop="name">Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Mbefo MK,Fares MB,Paleologou K,Oueslati A,Yin G,Tenreiro S,Pinto M,Outeiro T,Zweckstetter M,Masliah E,Lashuel HA</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate the effects of the A30P, E46K, and A53T Parkinson's disease-linked mutations on α-synuclein phosphorylation at residues Ser-87 and Ser-129.</div> <div itemprodp="datePublished">Fri Apr 10 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26462274"> <div itemprop="name">Reduced keratin expression in colorectal neoplasia and associated fields is reversible by diet and resection.</div> </a> <div itemprop="about">BMJ open gastroenterology</div> <div itemprop="author">Evans CA,Rosser R,Waby JS,Noirel J,Lai D,Wright PC,Williams EA,Riley SA,Bury JP,Corfe BM</div> <div itemprop="description">AM4300 was used in western blot to identify molecular alterations in the normal mucosa in the proximity of adenomatous polyps and assess the modulating effect of butyrate.</div> <div itemprodp="datePublished">Wed Oct 14 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25713082"> <div itemprop="name">Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Maganti AV,Maier B,Tersey SA,Sampley ML,Mosley AL,Özcan S,Pachaiyappan B,Woster PM,Hunter CS,Stein R,Mirmira RG</div> <div itemprop="description">AM4300 was used in western blot to test if lys methylation of Pdx1 by Set7/9 affects Pdx1 transcriptional activity</div> <div itemprodp="datePublished">Fri Apr 10 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25763610"> <div itemprop="name">Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum.</div> </a> <div itemprop="about">Molecular endocrinology (Baltimore, Md.)</div> <div itemprop="author">Liu Y,Li Y,Zhang D,Liu J,Gou K,Cui S</div> <div itemprop="description">AM4300 was used in western blot to elucidate the mechanism by which estradiol regulates progesterone production in the corpus luteum.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24828042"> <div itemprop="name">The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Chin RM,Fu X,Pai MY,Vergnes L,Hwang H,Deng G,Diep S,Lomenick B,Meli VS,Monsalve GC,Hu E,Whelan SA,Wang JX,Jung G,Solis GM,Fazlollahi F,Kaweeteerawat C,Quach A,Nili M,Krall AS,Godwin HA,Chang HR,Faull KF,Guo F,Jiang M,Trauger SA,Saghatelian A,Braas D,Christofk HR,Clarke CF,Teitell MA,Petrascheck M,Reue K,Jung ME,Frand AR,Huang J</div> <div itemprop="description">AM4300 was used in Western Blotting to show that α-ketoglutarate, a tricarboxylic acid cycle intermediate, extends the lifespan of adult Caenorhabditis elegans.</div> <div itemprodp="datePublished">Thu Jun 19 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24470357"> <div itemprop="name">Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines.</div> </a> <div itemprop="about">Arthritis & rheumatology (Hoboken, N.J.)</div> <div itemprop="author">Yik JH,Hu Z,Kumari R,Christiansen BA,Haudenschild DR</div> <div itemprop="description">AM4300 was used in western blot to test if CDK-9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25426782"> <div itemprop="name">IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Rovetta AI,Peña D,Hernández Del Pino RE,Recalde GM,Pellegrini J,Bigi F,Musella RM,Palmero DJ,Gutierrez M,Colombo MI,García VE</div> <div itemprop="description">AM4300 was used in western blot to study autophagy in Mycobacterium tuberculosis-infected patients.</div> <div itemprodp="datePublished">Tue Dec 08 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24755468"> <div itemprop="name">Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Ding Z,German P,Bai S,Reddy AS,Liu XD,Sun M,Zhou L,Chen X,Zhao X,Wu C,Zhang S,Mills GB,Jonasch E</div> <div itemprop="description">AM4300 was used in western blot to investigate how VHL-R67Q contributes to tumorigenesis.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23912456"> <div itemprop="name">Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Guo H,Gao M,Lu Y,Liang J,Lorenzi PL,Bai S,Hawke DH,Li J,Dogruluk T,Scott KL,Jonasch E,Mills GB,Ding Z</div> <div itemprop="description">AM4300 was used in western blot to study the phosphorylation of AKT and AKT2.</div> <div itemprodp="datePublished">Thu Jun 26 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24872548"> <div itemprop="name">Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Tang J,Ip JP,Ye T,Ng YP,Yung WH,Wu Z,Fang W,Fu AK,Ip NY</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of Mst3 in radial neuronal migration and final neuronal positioning in the developing mouse neocortex.</div> <div itemprodp="datePublished">Wed May 28 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25173988"> <div itemprop="name">Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.</div> </a> <div itemprop="about">Biochemical pharmacology</div> <div itemprop="author">Eberle M,Ebel P,Wegner MS,Männich J,Tafferner N,Ferreiros N,Birod K,Schreiber Y,Krishnamoorthy G,Willecke K,Geisslinger G,Grösch S,Schiffmann S</div> <div itemprop="description">AM4300 was used in western blot to study ceramide dysregulation in a chronic experimental autoimmune encephalomyelitis model</div> <div itemprodp="datePublished">Sat Nov 15 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25001863"> <div itemprop="name">SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Vachharajani VT,Liu T,Brown CM,Wang X,Buechler NL,Wells JD,Yoza BK,McCall CE</div> <div itemprop="description">AM4300 was used in western blot to investigate the effect of SIRT1 inhibition during sepsis</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23776059"> <div itemprop="name">Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers.</div> </a> <div itemprop="about">Molecular carcinogenesis</div> <div itemprop="author">Brouxhon SM,Kyrkanides S,Teng X,O'Banion MK,Clarke R,Byers S,Ma L</div> <div itemprop="description">AM4300 was used in western blot to study targeting sEcad for treatment of breast cancer.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24057668"> <div itemprop="name">Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Goodwin AF,Tidyman WE,Jheon AH,Sharir A,Zheng X,Charles C,Fagin JA,McMahon M,Diekwisch TG,Ganss B,Rauen KA,Klein OD</div> <div itemprop="description">AM4300 was used in western blot to demonstrate that Ras signaling is important for enamel formation in individuals with Costello syndrome and present mouse model system to dissect the roles of the Ras effector pathways in vivo.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24549040"> <div itemprop="name">C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Farg MA,Sundaramoorthy V,Sultana JM,Yang S,Atkinson RA,Levina V,Halloran MA,Gleeson PA,Blair IP,Soo KY,King AE,Atkin JD</div> <div itemprop="description">AM4300 was used in western blot to show that C9ORF72 regulates endosomal trafficking.</div> <div itemprodp="datePublished">Tue Jul 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24904080"> <div itemprop="name">Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.</div> </a> <div itemprop="about">American journal of physiology. Gastrointestinal and liver physiology</div> <div itemprop="author">Premkumar MH,Sule G,Nagamani SC,Chakkalakal S,Nordin A,Jain M,Ruan MZ,Bertin T,Dawson B,Zhang J,Schady D,Bryan NS,Campeau PM,Erez A,Lee B</div> <div itemprop="description">AM4300 was used in western blot to confirm the role of argininosuccinate lyase deficiency from enterocytes in the pathogenesis of necrotizing enterocolitis</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25117830"> <div itemprop="name">Pax6 is essential for the maintenance and multi-lineage differentiation of neural stem cells, and for neuronal incorporation into the adult olfactory bulb.</div> </a> <div itemprop="about">Stem cells and development</div> <div itemprop="author">Curto GG,Nieto-Estévez V,Hurtado-Chong A,Valero J,Gómez C,Alonso JR,Weruaga E,Vicario-Abejón C</div> <div itemprop="description">AM4300 was used in western blot to study the role of Pax6 in the maintenance and differentiation of adult neural stem cells and in adult neurogenesis</div> <div itemprodp="datePublished">Mon Dec 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25042778"> <div itemprop="name">Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice.</div> </a> <div itemprop="about">Pharmacology, biochemistry, and behavior</div> <div itemprop="author">Syhr KM,Kallenborn-Gerhardt W,Lu R,Olbrich K,Schmitz K,Männich J,Ferreiros-Bouzas N,Geisslinger G,Niederberger E,Schmidtko A</div> <div itemprop="description">AM4300 was used in western blot to examine the role of P2Y6 receptors in pain processing</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25200516"> <div itemprop="name">St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.</div> </a> <div itemprop="about">Behavioural brain research</div> <div itemprop="author">Tantra M,Kröcher T,Papiol S,Winkler D,Röckle I,Jatho J,Burkhardt H,Ronnenberg A,Gerardy-Schahn R,Ehrenreich H,Hildebrandt H</div> <div itemprop="description">AM4300 was used in western blot to study delta-9-tetrahydrocannabinol in St8sia2(-/-) mice</div> <div itemprodp="datePublished">Mon Dec 15 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23403205"> <div itemprop="name">Hydrostatic pressure enhances mitomycin C induced apoptosis in urothelial carcinoma cells.</div> </a> <div itemprop="about">Urologic oncology</div> <div itemprop="author">Chen SK,Chung CA,Cheng YC,Huang CJ,Ruaan RC,Chen WY,Li C,Tsao CW,Hu WW,Chien CC</div> <div itemprop="description">AM4300 was used in western blot to study the mechanism of the mitomycin C on urothelial carcinoma cells</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24742914"> <div itemprop="name">Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Sun Y,Chung HH,Woo AR,Lin VC</div> <div itemprop="description">AM4300 was used in western blot to investigate how PRMT6 promotes ERα activity.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25419658"> <div itemprop="name">Role of D-Limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Russo R,Cassiano MG,Ciociaro A,Adornetto A,Varano GP,Chiappini C,Berliocchi L,Tassorelli C,Bagetta G,Corasaniti MT</div> <div itemprop="description">AM4300 was used in Western Blotting to study the ability of bergamot essential oil to modulate autophagic pathways in human SH-SY5Y neuroblastoma cells.</div> <div itemprodp="datePublished">Tue Jan 26 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24859754"> <div itemprop="name">miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Chapnik E,Rivkin N,Mildner A,Beck G,Pasvolsky R,Metzl-Raz E,Birger Y,Amir G,Tirosh I,Porat Z,Israel LL,Lellouche E,Michaeli S,Lellouche JP,Izraeli S,Jung S,Hornstein E</div> <div itemprop="description">AM4300 was used in western blot to determine the in vivo functions of miR-142</div> <div itemprodp="datePublished">Fri May 23 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24938805"> <div itemprop="name">Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.</div> </a> <div itemprop="about">Molecular neurodegeneration</div> <div itemprop="author">Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P</div> <div itemprop="description">AM4300 was used in Western Blotting to understand and overcome the cause of sudden death in TDP-43 (A315T) mice.</div> <div itemprodp="datePublished">Tue Jun 17 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24928504"> <div itemprop="name">Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Chung L,Bailey D,Leen EN,Emmott EP,Chaudhry Y,Roberts LO,Curry S,Locker N,Goodfellow IG</div> <div itemprop="description">AM4300 was used in western blot to identify the components of the norovirus translation initiation factor complex</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24831131"> <div itemprop="name">Serum stability and physicochemical characterization of a novel amphipathic peptide C6M1 for siRNA delivery.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Jafari M,Xu W,Pan R,Sweeting CM,Karunaratne DN,Chen P</div> <div itemprop="description">AM4300 was used in western blot to investigate the use of peptides as carriers of short interfering RNA.</div> <div itemprodp="datePublished">Mon Jun 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25058378"> <div itemprop="name">PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Requejo-Aguilar R,Lopez-Fabuel I,Fernandez E,Martins LM,Almeida A,Bolaños JP</div> <div itemprop="description">AM4300 was used in western blot to show that that PINK1 deficiency triggers hypoxia-inducible factor-1α.</div> <div itemprodp="datePublished">Thu Jul 24 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24423080"> <div itemprop="name">A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury.</div> </a> <div itemprop="about">Cell communication and signaling : CCS</div> <div itemprop="author">Ashraf MI,Ebner M,Wallner C,Haller M,Khalid S,Schwelberger H,Koziel K,Enthammer M,Hermann M,Sickinger S,Soleiman A,Steger C,Vallant S,Sucher R,Brandacher G,Santer P,Dragun D,Troppmair J</div> <div itemprop="description">AM4300 was used in western blot to demonstrate that p38MAPK activation elevates mitochondrial ROS levels.</div> <div itemprodp="datePublished">Tue Jan 14 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25984365"> <div itemprop="name">CD137 enhancement of HPV positive head and neck squamous cell carcinoma tumor clearance.</div> </a> <div itemprop="about">Vaccines</div> <div itemprop="author">Lucido CT,Vermeer PD,Wieking BG,Vermeer DW,Lee JH</div> <div itemprop="description">AM4300 was used in western blot to study the effect of CD137 on HPV positive head and neck squamous cell carcinoma tumor clearance</div> <div itemprodp="datePublished">Tue Sep 08 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24465881"> <div itemprop="name">Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Bayer ML,Schjerling P,Herchenhan A,Zeltz C,Heinemeier KM,Christensen L,Krogsgaard M,Gullberg D,Kjaer M</div> <div itemprop="description">AM4300 was used in western blot to characterize engineered human tendon tissue and how release of tensile strain changes matrix architecture, disturbs cell adhesions, and induces an inflammatory phenotype</div> <div itemprodp="datePublished">Wed Oct 29 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23047288"> <div itemprop="name">Differential glial activation during the degeneration of Purkinje cells and mitral cells in the PCD mutant mice.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Baltanás FC,Berciano MT,Valero J,Gómez C,Díaz D,Alonso JR,Lafarga M,Weruaga E</div> <div itemprop="description">AM4300 was used in western blot to study gliosis during Purkinje and mitral cell death in the Purkinje Cell Degeneration mouse.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23365451"> <div itemprop="name">Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Kim S,Ishida H,Yamane D,Yi M,Swinney DC,Foung S,Lemon SM</div> <div itemprop="description">AM4300 was used in western blot to study the roles of MAPK-related kinase and MKNK-1 in HCV replication and cellular entry.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24048738"> <div itemprop="name">Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.</div> </a> <div itemprop="about">Molecular cancer therapeutics</div> <div itemprop="author">Enthammer M,Papadakis ES,Salomé Gachet M,Deutsch M,Schwaiger S,Koziel K,Ashraf MI,Khalid S,Wolber G,Packham G,Cutress RI,Stuppner H,Troppmair J</div> <div itemprop="description">AM4300 was used in Western Blotting to report the development of a protocol for the purification and isolation of biologically active constituents of Thioflavin S and the characterization of the novel compound Thio-2.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23406989"> <div itemprop="name">Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis.</div> </a> <div itemprop="about">Arthritis research & therapy</div> <div itemprop="author">Hasegawa A,Nakahara H,Kinoshita M,Asahara H,Koziol J,Lotz MK</div> <div itemprop="description">AM4300 was used in Western Blotting to characterise the patterns and relations of ageing-related and osteoarthritis-associated changes in anterior cruciate ligament cells and the extracellular matrix.</div> <div itemprodp="datePublished">Thu Feb 14 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23750663"> <div itemprop="name">Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Gao Y,Yechikov S,Vázquez AE,Chen D,Nie L</div> <div itemprop="description">AM4300 was used in Western Blotting to study the molecular aetiology of DFNA2.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23974097"> <div itemprop="name">Tumor protein D52 represents a negative regulator of ATM protein levels.</div> </a> <div itemprop="about">Cell cycle (Georgetown, Tex.)</div> <div itemprop="author">Chen Y,Kamili A,Hardy JR,Groblewski GE,Khanna KK,Byrne JA</div> <div itemprop="description">AM4300 was used in western blot to study the relationship between tumor protein D52 and ATM protein</div> <div itemprodp="datePublished">Sun Sep 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23255126"> <div itemprop="name">Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9.</div> </a> <div itemprop="about">Cell cycle (Georgetown, Tex.)</div> <div itemprop="author">Chee JL,Saidin S,Lane DP,Leong SM,Noll JE,Neilsen PM,Phua YT,Gabra H,Lim TM</div> <div itemprop="description">AM4300 was used in Western Blotting to suggest the inhibition of caspase-9 as a mechanism in evading apoptosis in tumours with high-level cytoplasmically localized p53 expression.</div> <div itemprodp="datePublished">Tue Jan 15 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23303826"> <div itemprop="name">Human cytomegalovirus chemokine receptor US28 induces migration of cells on a CX3CL1-presenting surface.</div> </a> <div itemprop="about">The Journal of general virology</div> <div itemprop="author">Hjortø GM,Kiilerich-Pedersen K,Selmeczi D,Kledal TN,Larsen NB</div> <div itemprop="description">AM4300 was used in Western Blotting to indicate that infected cells probably move more than uninfected cells in inflamed tissues with high CX3CL1 expression, with soluble chemokines affecting the final migration.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24019071"> <div itemprop="name">Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Yugawa T,Nishino K,Ohno S,Nakahara T,Fujita M,Goshima N,Umezawa A,Kiyono T</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that the NOTCH-ROCK pathway is critical for cellular differentiation, and loss of self-renewal capacity in a subset of immature cells.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23892475"> <div itemprop="name">Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.</div> </a> <div itemprop="about">Endocrinology</div> <div itemprop="author">Dokas J,Chadt A,Nolden T,Himmelbauer H,Zierath JR,Joost HG,Al-Hasani H</div> <div itemprop="description">AM4300 was used in western blot to investigate the role of Tbc1d1 in insulin- and AICAR-stimulated glucose uptake in skeletal muscle</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23499904"> <div itemprop="name">Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells.</div> </a> <div itemprop="about">Cellular signalling</div> <div itemprop="author">Rejon CA,Ho CC,Wang Y,Zhou X,Bernard DJ,Hébert TE</div> <div itemprop="description">AM4300 was used in western blot to demonstrate that cycloheximide produces inhibin-like effects in gonadotropes by preventing de novo synthesis of ACVR2.</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23481610"> <div itemprop="name">Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation.</div> </a> <div itemprop="about">Toxicology and applied pharmacology</div> <div itemprop="author">Takeuchi-Yorimoto A,Noto T,Yamada A,Miyamae Y,Oishi Y,Matsumoto M</div> <div itemprop="description">AM4300 was used in western blot to study nonalcoholic steatohepatitis using rats.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24068106"> <div itemprop="name">Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.</div> </a> <div itemprop="about">Biology of reproduction</div> <div itemprop="author">Wardell JR,Hodgkinson KM,Binder AK,Seymour KA,Korach KS,Vanderhyden BC,Freiman RN</div> <div itemprop="description">AM4300 was used in Western Blotting to elucidate the relationship between oestrogen signalling and the TAF4B subunit in normal or tumourigenic ovaries.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23271561"> <div itemprop="name">N-cadherin expression is regulated by UTP in schwannoma cells.</div> </a> <div itemprop="about">Purinergic signalling</div> <div itemprop="author">Martiáñez T,Lamarca A,Casals N,Gella A</div> <div itemprop="description">AM4300 was used in western blot to examine the role of UTP on N-cadherin expression in schwannoma cells</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23376368"> <div itemprop="name">In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Murakami K,Jiang YP,Tanaka T,Bando Y,Mitrovic B,Yoshida S</div> <div itemprop="description">AM4300 was used in western blot to investigate the functions of KLK6 in oligodendrocyte lineage cell development and myelin protein production</div> <div itemprodp="datePublished">Tue Apr 16 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23823934"> <div itemprop="name">Interaction of PICK1 with C-terminus of growth hormone-releasing hormone receptor (GHRHR) modulates trafficking and signal transduction of human GHRHR.</div> </a> <div itemprop="about">Journal of pharmacological sciences</div> <div itemprop="author">Katsushima Y,Sato T,Yamada C,Ito M,Suzuki Y,Ogawa E,Sukegawa I,Sukegawa J,Fukunaga K,Yanagisawa T</div> <div itemprop="description">AM4300 was used in western blot to identify protein interacting with C-kinase as a binding partner of growth hormone-releasing hormone receptor.</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23355257"> <div itemprop="name">Mitochondrial DNA (mtDNA) in brain samples from patients with major psychiatric disorders: gene expression profiles, mtDNA content and presence of the mtDNA common deletion.</div> </a> <div itemprop="about">American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics</div> <div itemprop="author">Torrell H,Montaña E,Abasolo N,Roig B,Gaviria AM,Vilella E,Martorell L</div> <div itemprop="description">AM4300 was used in western blot to determine if mitochondrial DNA expression or content contribute to the mitochondrial dysfunction observed in schizophrenia, bipolar disorder, and major depressive disorder.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23154181"> <div itemprop="name">SnoN/SKIL modulates proliferation through control of hsa-miR-720 transcription in esophageal cancer cells.</div> </a> <div itemprop="about">Biochemical and biophysical research communications</div> <div itemprop="author">Shinozuka E,Miyashita M,Mizuguchi Y,Akagi I,Kikuchi K,Makino H,Matsutani T,Hagiwara N,Nomura T,Uchida E,Takizawa T</div> <div itemprop="description">AM4300 was used in western blot to study mechanisms of transcriptional regulation of miRNAs using esophageal squamous cell carcinoma.</div> <div itemprodp="datePublished">Fri Jan 04 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23344777"> <div itemprop="name">Surface proteins of C6/36 cells involved in dengue virus 4 binding and entry.</div> </a> <div itemprop="about">Archives of virology</div> <div itemprop="author">Vega-Almeida TO,Salas-Benito M,De Nova-Ocampo MA,Del Angel RM,Salas-Benito JS</div> <div itemprop="description">AM4300 was used in western blot to identify host proteins involved in Dengue virus cell entry.</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23431407"> <div itemprop="name">Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gao Y,Yechikov S,Vazquez AE,Chen D,Nie L</div> <div itemprop="description">AM4300 was used in western blot to examine the role of heat shock proteins in the biogenesis of KCNQ4 channels</div> <div itemprodp="datePublished">Thu Aug 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23609441"> <div itemprop="name">α-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Sasaki H,Toda T,Furukawa T,Mawatari Y,Takaesu R,Shimizu M,Wada R,Kato D,Utsugi T,Ohtsu M,Murakami Y</div> <div itemprop="description">AM4300 was used in Western Blotting to define FUT8 as a novel factor for haemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation.</div> <div itemprodp="datePublished">Fri Jun 07 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23609441"> <div itemprop="name">α-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Sasaki H,Toda T,Furukawa T,Mawatari Y,Takaesu R,Shimizu M,Wada R,Kato D,Utsugi T,Ohtsu M,Murakami Y</div> <div itemprop="description">AM4300 was used in Western Blotting to define FUT8 as a novel factor for haemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation.</div> <div itemprodp="datePublished">Fri Jun 07 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23921388"> <div itemprop="name">Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Jakobsson ME,Moen A,Bousset L,Egge-Jacobsen W,Kernstock S,Melki R,Falnes PØ</div> <div itemprop="description">AM4300 was used in western blot to investigate the mechanism and function of trimethylated HSPA8.</div> <div itemprodp="datePublished">Fri Sep 27 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22886345"> <div itemprop="name">A novel role for junctional adhesion molecule-A in tumor proliferation: modulation by an anti-JAM-A monoclonal antibody.</div> </a> <div itemprop="about">International journal of cancer</div> <div itemprop="author">Goetsch L,Haeuw JF,Beau-Larvor C,Gonzalez A,Zanna L,Malissard M,Lepecquet AM,Robert A,Bailly C,Broussas M,Corvaia N</div> <div itemprop="description">AM4300 was used in Western Blotting to show for the first time that JAM-A can interfere with tumor proliferation and suggest that JAM-A is a potential novel target in oncology.</div> <div itemprodp="datePublished">Fri Mar 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23528838"> <div itemprop="name">Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2.</div> </a> <div itemprop="about">Bone</div> <div itemprop="author">Ishida K,Acharya C,Christiansen BA,Yik JH,DiCesare PE,Haudenschild DR</div> <div itemprop="description">AM4300 was used in western blot to test if COMP binds to BMP-2 and test if COMP promotes the biological activity of BMP-2 with respect to osteogenesis.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22246438"> <div itemprop="name">A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Shinohara R,Thumkeo D,Kamijo H,Kaneko N,Sawamoto K,Watanabe K,Takebayashi H,Kiyonari H,Ishizaki T,Furuyashiki T,Narumiya S</div> <div itemprop="description">AM4300 was used in western blot to investigate factors that regulate excitatory and inhibitory neuron migration.</div> <div itemprodp="datePublished">Sun Jan 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22323479"> <div itemprop="name">Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Hutchins AP,Poulain S,Miranda-Saavedra D</div> <div itemprop="description">AM4300 was used in western blot to identify STAT3-controlled effectors of the anti-inflammatory response.</div> <div itemprodp="datePublished">Thu Mar 29 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22090132"> <div itemprop="name">GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Chen Z,Kolokoltsov AA,Wang J,Adhikary S,Lorinczi M,Elferink LA,Davey RA</div> <div itemprop="description">AM4300 was used in knockdown western blot and western blot to test if GRB2 contributes to controlling infection by retroviruses by affecting receptor function.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21503881"> <div itemprop="name">Nestin expression is lost in ventricular fibroblasts during postnatal development of the rat heart and re-expressed in scar myofibroblasts.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Béguin PC,Gosselin H,Mamarbachi M,Calderone A</div> <div itemprop="description">AM4300 was used in western blot to examine nestin expression in ventricular fibroblasts.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22246002"> <div itemprop="name">Abnormal platelet aggregation in idiopathic pulmonary arterial hypertension: role of nitric oxide.</div> </a> <div itemprop="about">American journal of physiology. Lung cellular and molecular physiology</div> <div itemprop="author">Aytekin M,Aulak KS,Haserodt S,Chakravarti R,Cody J,Minai OA,Dweik RA</div> <div itemprop="description">AM4300 was used in western blot to determine the phenotype of the platelets in patients with idiopathic pulmonary arterial hypertension.</div> <div itemprodp="datePublished">Thu Mar 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22693207"> <div itemprop="name">The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.</div> </a> <div itemprop="about">American journal of physiology. Endocrinology and metabolism</div> <div itemprop="author">Szekeres F,Chadt A,Tom RZ,Deshmukh AS,Chibalin AV,Björnholm M,Al-Hasani H,Zierath JR</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that TBC1D1 plays a role in regulation of glucose metabolism in skeletal muscle.</div> <div itemprodp="datePublished">Wed Aug 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22628289"> <div itemprop="name">High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Turinetto V,Orlando L,Sanchez-Ripoll Y,Kumpfmueller B,Storm MP,Porcedda P,Minieri V,Saviozzi S,Accomasso L,Cibrario Rocchietti E,Moorwood K,Circosta P,Cignetti A,Welham MJ,Giachino C</div> <div itemprop="description">AM4300 was used in western blot to test if H2AX phosphorylation is important in maintaining self-renewal of mouse embryonic stem cells.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22896632"> <div itemprop="name">Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Lopez-Ramirez MA,Fischer R,Torres-Badillo CC,Davies HA,Logan K,Pfizenmaier K,Male DK,Sharrack B,Romero IA</div> <div itemprop="description">AM4300 was used in western blot to study the role of caspases in cytokine-induced barrier breakdown during neuroinflammation</div> <div itemprodp="datePublished">Sat Sep 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22331355"> <div itemprop="name">Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages.</div> </a> <div itemprop="about">Journal of cell science</div> <div itemprop="author">Bartolomé-Martín D,Ramírez-Franco J,Castro E,Sánchez-Prieto J,Torres M</div> <div itemprop="description">AM4300 was used in Western Blotting to determine whether nerve terminals use multiple pathways of endocytosis to recycle synaptic vesicles.</div> <div itemprodp="datePublished">Sun Jan 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22914733"> <div itemprop="name">Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Lu C,Lin L,Tan H,Wu H,Sherman SL,Gao F,Jin P,Chen D</div> <div itemprop="description">AM4300 was used in western blot to characterize mice carrying the human FMR premutation allele.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22832245"> <div itemprop="name">The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1).</div> </a> <div itemprop="about">RNA biology</div> <div itemprop="author">Gao WL,Liu M,Yang Y,Yang H,Liao Q,Bai Y,Li YX,Li D,Peng C,Wang YL</div> <div itemprop="description">AM4300 was used in western blot to identify the roles of H9 gene via the miR-675 pathway in the pathogenesis of preeclampsia.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22342292"> <div itemprop="name">Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts.</div> </a> <div itemprop="about">Toxicology letters</div> <div itemprop="author">Romoser AA,Figueroa DE,Sooresh A,Scribner K,Chen PL,Porter W,Criscitiello MF,Sayes CM</div> <div itemprop="description">AM4300 was used in western blot to assess the effects of nanoparticles on inflammation and cellular stress.</div> <div itemprodp="datePublished">Sat May 05 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22133893"> <div itemprop="name">Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss.</div> </a> <div itemprop="about">Neuroscience</div> <div itemprop="author">Gómez C,Curto GG,Baltanás FC,Valero J,O'Shea E,Colado MI,Díaz D,Weruaga E,Alonso JR</div> <div itemprop="description">AM4300 was used in western blot to study the response of the serotonergic centrifugal system after mitral cell loss using Purkinje cell degeneration mutant mice.</div> <div itemprodp="datePublished">Tue Jan 10 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22819674"> <div itemprop="name">The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.</div> </a> <div itemprop="about">Developmental biology</div> <div itemprop="author">Verma S,Salmans ML,Geyfman M,Wang H,Yu Z,Lu Z,Zhao F,Lipkin SM,Andersen B</div> <div itemprop="description">AM4300 was used as a Control in experiments to define the role of Agr2 in normal mammary gland development using Agr2 knockout and conditional overexpression mouse models.</div> <div itemprodp="datePublished">Sat Sep 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22819674"> <div itemprop="name">The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.</div> </a> <div itemprop="about">Developmental biology</div> <div itemprop="author">Verma S,Salmans ML,Geyfman M,Wang H,Yu Z,Lu Z,Zhao F,Lipkin SM,Andersen B</div> <div itemprop="description">AM4300 was used as a Control in experiments to define the role of Agr2 in normal mammary gland development using Agr2 knockout and conditional overexpression mouse models.</div> <div itemprodp="datePublished">Sat Sep 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23213437"> <div itemprop="name">The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Yamamoto M,Matsuzaki T,Takahashi R,Adachi E,Maeda Y,Yamaguchi S,Kitayama H,Echizenya M,Morioka Y,Alexander DB,Yagi T,Itohara S,Nakamura T,Akiyama H,Noda M</div> <div itemprop="description">AM4300 was used in western blot to characterize mice with reduced Reck-expression</div> <div itemprodp="datePublished">Tue May 15 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22245112"> <div itemprop="name">Mouse germ cell clusters form by aggregation as well as clonal divisions.</div> </a> <div itemprop="about">Mechanisms of development</div> <div itemprop="author">Mork L,Tang H,Batchvarov I,Capel B</div> <div itemprop="description">AM4300 was used in immunohistochemistry to test if germ cell clusters in the mammalian gonad arise through incomplete cell divisions.</div> <div itemprodp="datePublished">Thu Jul 05 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22357874"> <div itemprop="name">Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.</div> </a> <div itemprop="about">Journal of biomolecular screening</div> <div itemprop="author">Ding Z,German P,Bai S,Feng Z,Gao M,Si W,Sobieski MM,Stephan CC,Mills GB,Jonasch E</div> <div itemprop="description">AM4300 was used in Western Blotting to develop a cell-based screening tool to identify compounds that stabilize or upregulate full-length, point-mutated Von Hippel-Lindau protein.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22201751"> <div itemprop="name">Profiling of linker histone variants in ovarian cancer.</div> </a> <div itemprop="about">Frontiers in bioscience (Landmark edition)</div> <div itemprop="author">Medrzycki M,Zhang Y,McDonald JF,Fan Y</div> <div itemprop="description">AM4300 was used in western blot to elucidate the impact of H in ovarian cancer.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22272336"> <div itemprop="name">Uncovering suitable reference proteins for expression studies in human adipose tissue with relevance to obesity.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Pérez-Pérez R,López JA,García-Santos E,Camafeita E,Gómez-Serrano M,Ortega-Delgado FJ,Ricart W,Fernández-Real JM,Peral B</div> <div itemprop="description">AM4300 was used in western blot to identify and validate reference proteins for data standardization.</div> <div itemprodp="datePublished">Mon Jun 11 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22693623"> <div itemprop="name">Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Esteves TC,Psathaki OE,Pfeiffer MJ,Balbach ST,Zeuschner D,Shitara H,Yonekawa H,Siatkowski M,Fuellen G,Boiani M</div> <div itemprop="description">AM4300 was used in immunocytochemistry to develop and use methods to directly assess maternal and embryonic products.</div> <div itemprodp="datePublished">Tue Oct 02 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22722493"> <div itemprop="name">Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.</div> </a> <div itemprop="about">Cell cycle (Georgetown, Tex.)</div> <div itemprop="author">Lee K,Rhee K</div> <div itemprop="description">AM4300 was used in Western Blotting to characterise the specific cleavage of pericentrin B by separase at the exit of mitosis.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22378783"> <div itemprop="name">Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Lönn P,Vanlandewijck M,Raja E,Kowanetz M,Watanabe Y,Kowanetz K,Vasilaki E,Heldin CH,Moustakas A</div> <div itemprop="description">AM4300 was used in Western Blotting to demonstrate that transforming growth factor Β induces salt-inducible kinase 1 levels via a direct transcriptional mechanism, and characterise a putative enhancer element on the SIK1 gene.</div> <div itemprodp="datePublished">Fri Apr 13 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21292134"> <div itemprop="name">Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice.</div> </a> <div itemprop="about">Journal of the American College of Cardiology</div> <div itemprop="author">Fabritz L,Hoogendijk MG,Scicluna BP,van Amersfoorth SC,Fortmueller L,Wolf S,Laakmann S,Kreienkamp N,Piccini I,Breithardt G,Noppinger PR,Witt H,Ebnet K,Wichter T,Levkau B,Franke WW,Pieperhoff S,de Bakker JM,Coronel R,Kirchhof P</div> <div itemprop="description">AM4300 was used in western blot to test the effect of ventricular load on cardiomyopathy.</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21597389"> <div itemprop="name">Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer.</div> </a> <div itemprop="about">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</div> <div itemprop="author">Selinger CI,Cooper WA,Al-Sohaily S,Mladenova DN,Pangon L,Kennedy CW,McCaughan BC,Stirzaker C,Kohonen-Corish MR</div> <div itemprop="description">AM4300 was used in western blot to evaluate the prognostic significance of SATB1 expression in lung cancer.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21724609"> <div itemprop="name">Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.</div> </a> <div itemprop="about">Nucleic acids research</div> <div itemprop="author">Žumer K,Plemenitaš A,Saksela K,Peterlin BM</div> <div itemprop="description">AM4300 was used in western blot to characterize a APECED patient mutation.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21343394"> <div itemprop="name">Cyclin D1 inhibits mitochondrial activity in B cells.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Tchakarska G,Roussel M,Troussard X,Sola B</div> <div itemprop="description">AM4300 was used in Immunocytochemistry-immunoflourescence to show in an model of cyclin D1 fusion protein transduction in mature B cells, that, cyclin D1 inhibits mitochondrial activity.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20980461"> <div itemprop="name">Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite.</div> </a> <div itemprop="about">Diabetes</div> <div itemprop="author">Ilnytska O,Stütz AM,Park-York M,York DA,Ribnicky DM,Zuberi A,Cefalu WT,Argyropoulos G</div> <div itemprop="description">AM4300 was used in Western Blotting to determine molecular mechanisms for the activation of hypothalamic Agrp and identify compounds that stimulate appetite in mice.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21383688"> <div itemprop="name">KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Jiffar T,Yilmaz T,Lee J,Hanna E,El-Naggar A,Yu D,Myers JN,Kupferman ME</div> <div itemprop="description">AM4300 was used in Western Blotting to study the role of KiSS1 loss in biologically aggressive head and neck squamous cell carcinoma, and suggest potential targets for therapy in cisplatin-resistant cancers.</div> <div itemprodp="datePublished">Thu Jul 14 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20677910"> <div itemprop="name">C-terminus of heat shock cognate 70 interacting protein increases following stroke and impairs survival against acute oxidative stress.</div> </a> <div itemprop="about">Antioxidants & redox signaling</div> <div itemprop="author">Stankowski JN,Zeiger SL,Cohen EL,DeFranco DB,Cai J,McLaughlin B</div> <div itemprop="description">AM4300 was used in western blot to test if C-terminus of HSC70 interacting protein upregulation enhances neural survival</div> <div itemprodp="datePublished">Sun May 15 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20677910"> <div itemprop="name">C-terminus of heat shock cognate 70 interacting protein increases following stroke and impairs survival against acute oxidative stress.</div> </a> <div itemprop="about">Antioxidants & redox signaling</div> <div itemprop="author">Stankowski JN,Zeiger SL,Cohen EL,DeFranco DB,Cai J,McLaughlin B</div> <div itemprop="description">AM4300 was used in western blot to test if C-terminus of HSC70 interacting protein upregulation enhances neural survival</div> <div itemprodp="datePublished">Sun May 15 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21697654"> <div itemprop="name">Development of an Fn14 agonistic antibody as an anti-tumor agent.</div> </a> <div itemprop="about">mAbs</div> <div itemprop="author">Michaelson JS,Amatucci A,Kelly R,Su L,Garber E,Day ES,Berquist L,Cho S,Li Y,Parr M,Wille L,Schneider P,Wortham K,Burkly LC,Hsu YM,Joseph IB</div> <div itemprop="description">AM4300 was used in western blot to assess modulation of the TWEAK-Fn4 pathway as a therapeutic for oncology.</div> <div itemprodp="datePublished">Wed Jan 11 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21518850"> <div itemprop="name">Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Selvais C,D'Auria L,Tyteca D,Perrot G,Lemoine P,Troeberg L,Dedieu S,Noël A,Nagase H,Henriet P,Courtoy PJ,Marbaix E,Emonard H</div> <div itemprop="description">AM4300 was used in western blot to elucidate the mechanisms by which cholesterol regulates LRP-1 levels and function at the plasma membrane.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21406170"> <div itemprop="name">Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Revuelta-Cervantes J,Mayoral R,Miranda S,González-Rodríguez A,Fernández M,Martín-Sanz P,Valverde AM</div> <div itemprop="description">AM4300 was used in western blot to elucidate the role of PTP1B in liver regeneration.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21519330"> <div itemprop="name">Loss of VOPP1 overexpression in squamous carcinoma cells induces apoptosis through oxidative cellular injury.</div> </a> <div itemprop="about">Laboratory investigation; a journal of technical methods and pathology</div> <div itemprop="author">Baras AS,Solomon A,Davidson R,Moskaluk CA</div> <div itemprop="description">AM4300 was used in western blot to determine the role that VOPP1 has in human squamous cell carcinoma.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21549111"> <div itemprop="name">The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.</div> </a> <div itemprop="about">Developmental biology</div> <div itemprop="author">Billington CJ,Ng B,Forsman C,Schmidt B,Bagchi A,Symer DE,Schotta G,Gopalakrishnan R,Sarver AL,Petryk A</div> <div itemprop="description">AM4300 was used in western blot to examine the varied penetrance and expressivity of the Twisted gastrulation mutation in mice.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20100709"> <div itemprop="name">Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.</div> </a> <div itemprop="about">Innate immunity</div> <div itemprop="author">Feingold KR,Shigenaga JK,Patzek SM,Chui LG,Moser A,Grunfeld C</div> <div itemprop="description">AM4300 was used in western blot to examine ChREBP expression during the acute phase response</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21210908"> <div itemprop="name">Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation.</div> </a> <div itemprop="about">Genes to cells : devoted to molecular & cellular mechanisms</div> <div itemprop="author">Inaki M,Kato D,Utsugi T,Onoda F,Hanaoka F,Murakami Y</div> <div itemprop="description">AM4300 was used in western blot to study the role in Cdk regulation of the novel gene magoh identified in a genetic screen of a murine cell cycle mutant</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22087843"> <div itemprop="name">Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.</div> </a> <div itemprop="about">BMC molecular biology</div> <div itemprop="author">Miki T,Kamikawa Y,Kurono S,Kaneko Y,Katahira J,Yoneda Y</div> <div itemprop="description">AM4300 was used in western blot to identify binding partners of Stau2 in dendritic cells</div> <div itemprodp="datePublished">Wed Nov 16 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21390327"> <div itemprop="name">PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Wang D,Li Y,Wu C,Liu Y</div> <div itemprop="description">AM4300 was used in western blot to determine if PINCH1 translocates to the nucleus and regulates gene expression.</div> <div itemprodp="datePublished">Thu Feb 24 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20606037"> <div itemprop="name">Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.</div> </a> <div itemprop="about">Clinical cancer research : an official journal of the American Association for Cancer Research</div> <div itemprop="author">Smith NR,Baker D,James NH,Ratcliffe K,Jenkins M,Ashton SE,Sproat G,Swann R,Gray N,Ryan A,Jürgensmeier JM,Womack C</div> <div itemprop="description">AM4300 was used in western blot to examine VEGF receptor expression in tumor cells</div> <div itemprodp="datePublished">Thu Jul 15 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20926668"> <div itemprop="name">Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Nassirpour R,Bahima L,Lalive AL,Lüscher C,Luján R,Slesinger PA</div> <div itemprop="description">AM4300 was used in western blot to investigate the effect of morphine on neuronal GIRK signaling</div> <div itemprodp="datePublished">Wed Oct 06 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20648623"> <div itemprop="name">Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Dasgupta J,Kar S,Liu R,Joseph J,Kalyanaraman B,Remington SJ,Chen C,Melendez JA</div> <div itemprop="description">AM4300 was used in western blot to report the redox-responsive molecular signals that drive senescence-associated matrix metalloproteinase-1 expression</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20506192"> <div itemprop="name">MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Smrt RD,Szulwach KE,Pfeiffer RL,Li X,Guo W,Pathania M,Teng ZQ,Luo Y,Peng J,Bordey A,Jin P,Zhao X</div> <div itemprop="description">AM4300 was used in western blot to investigate the role of miR-137 in neuronal maturation</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20974982"> <div itemprop="name">The Chlamydia muridarum-induced IFN-β response is TLR3-dependent in murine oviduct epithelial cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Derbigny WA,Johnson RM,Toomey KS,Ofner S,Jayarapu K</div> <div itemprop="description">AM4300 was used in western blot to study the role of TLR3 in the Chlamydia-induced IFN-beta response using oviduct epithelial cells</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20656926"> <div itemprop="name">Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Weber KS,Hildner K,Murphy KM,Allen PM</div> <div itemprop="description">AM4300 was used in western blot to examine the T cell subset responses to Ca(2+) signals</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20581455"> <div itemprop="name">Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations.</div> </a> <div itemprop="about">Cell cycle (Georgetown, Tex.)</div> <div itemprop="author">Miller ES,Berman SD,Yuan TL,Lees JA</div> <div itemprop="description">AM4300 was used in western blot to determine the role of E2F4 in bone development using mutant mice</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20147520"> <div itemprop="name">Murine norovirus-1 cell entry is mediated through a non-clathrin-, non-caveolae-, dynamin- and cholesterol-dependent pathway.</div> </a> <div itemprop="about">The Journal of general virology</div> <div itemprop="author">Gerondopoulos A,Jackson T,Monaghan P,Doyle N,Roberts LO</div> <div itemprop="description">AM4300 was used in Western Blotting to elucidate the mechanisms of murine norovirus-1 cell entry.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20147520"> <div itemprop="name">Murine norovirus-1 cell entry is mediated through a non-clathrin-, non-caveolae-, dynamin- and cholesterol-dependent pathway.</div> </a> <div itemprop="about">The Journal of general virology</div> <div itemprop="author">Gerondopoulos A,Jackson T,Monaghan P,Doyle N,Roberts LO</div> <div itemprop="description">AM4300 was used in Western Blotting to elucidate the mechanisms of murine norovirus-1 cell entry.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20558765"> <div itemprop="name">PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells.</div> </a> <div itemprop="about">American journal of physiology. Gastrointestinal and liver physiology</div> <div itemprop="author">Dalmasso G,Nguyen HT,Charrier-Hisamuddin L,Yan Y,Laroui H,Demoulin B,Sitaraman SV,Merlin D</div> <div itemprop="description">AM4300 was used in western blot to test if l-Ala-gamma-d-Glu-meso-DAP is transported into intestinal epithelial cells via PepT1</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20801607"> <div itemprop="name">Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo.</div> </a> <div itemprop="about">Journal of vascular surgery</div> <div itemprop="author">Andersen ND,Chopra A,Monahan TS,Malek JY,Jain M,Pradhan L,Ferran C,LoGerfo FW</div> <div itemprop="description">AM4300 was used in immunocytochemistry and immunohistochemistry to use three rapid siRNA transfection techniques to silence endothelial genes in the human saphenous vein</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20144686"> <div itemprop="name">Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression.</div> </a> <div itemprop="about">Molecular and cellular endocrinology</div> <div itemprop="author">Peluso JJ,Liu X,Gawkowska A,Lodde V,Wu CA</div> <div itemprop="description">AM4300 was used in western blot to study the function of progesterone receptor membrane component-1 monomers and dimers</div> <div itemprodp="datePublished">Fri May 14 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20619372"> <div itemprop="name">Comparison of two dimensional electrophoresis mouse colon proteomes before and after knocking out Aquaporin 8.</div> </a> <div itemprop="about">Journal of proteomics</div> <div itemprop="author">Magdeldin S,Li H,Yoshida Y,Enany S,Zhang Y,Xu B,Fujinaka H,Yaoita E,Yamamoto T</div> <div itemprop="description">AM4300 was used in western blot to study protein alterations that contribute to AQP8 regulation and trafficking</div> <div itemprodp="datePublished">Fri Sep 10 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20345922"> <div itemprop="name">N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus.</div> </a> <div itemprop="about">The European journal of neuroscience</div> <div itemprop="author">Ouardouz M,Lema P,Awad PN,Di Cristo G,Carmant L</div> <div itemprop="description">AM4300 was used in Western Blotting to provide a new hypothesis of cellular changes following hyperthermic seizures in predisposed individuals, and may help in the design of therapeutic strategies to prevent epileptogenesis following prolonged febrile seizures.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19940015"> <div itemprop="name">Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules.</div> </a> <div itemprop="about">Molecular biology of the cell</div> <div itemprop="author">Qiang L,Yu W,Liu M,Solowska JM,Baas PW</div> <div itemprop="description">AM4300 was used in western blot to test if basic fibroblast growth factor enhances axonal branching</div> <div itemprodp="datePublished">Fri Jan 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20127821"> <div itemprop="name">Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development.</div> </a> <div itemprop="about">The Journal of comparative neurology</div> <div itemprop="author">Nakamura Y,Lee S,Haddox CL,Weaver EJ,Lemmon VP</div> <div itemprop="description">AM4300 was used in western blot to elucidate the function of the L1 cytoplasmic domain.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20331855"> <div itemprop="name">Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human Immunodeficiency Virus Type 1 protease autoprocessing.</div> </a> <div itemprop="about">Retrovirology</div> <div itemprop="author">Huang L,Hall A,Chen C</div> <div itemprop="description">AM4300 was used in Western Blotting to study the effects of different amino acid residues within the NL4-3 protease on modulating precursor structures for the regulation of protease autoprocessing in an HIV-infected cell.</div> <div itemprodp="datePublished">Tue Mar 23 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20689587"> <div itemprop="name">Parkin is protective against proteotoxic stress in a transgenic zebrafish model.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Fett ME,Pilsl A,Paquet D,van Bebber F,Haass C,Tatzelt J,Schmid B,Winklhofer KF</div> <div itemprop="description">AM4300 was used in western blot to characterize parkin knockouts of Danio rerio</div> <div itemprodp="datePublished">Fri Jul 30 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19892711"> <div itemprop="name">MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Nguyen HT,Dalmasso G,Yan Y,Laroui H,Dahan S,Mayer L,Sitaraman SV,Merlin D</div> <div itemprop="description">AM4300 was used in western blot to investigate if microRNAs regulate CD98 expression during intestinal epithelial cell differentiation and inflammation</div> <div itemprodp="datePublished">Fri Jan 08 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21203393"> <div itemprop="name">Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Qureshi A,Subathra M,Grey A,Schey K,Del Poeta M,Luberto C</div> <div itemprop="description">AM4300 was used in Western Blotting to identify the sphingolipid pathway as a requirement for the exertion of neutrophil killing activity against Cryptococcus neoformans.</div> <div itemprodp="datePublished">Tue Dec 28 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21304177"> <div itemprop="name">A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Murai R,Yoshida Y,Muraguchi T,Nishimoto E,Morioka Y,Kitayama H,Kondoh S,Kawazoe Y,Hiraoka M,Uesugi M,Noda M</div> <div itemprop="description">AM4300 was used in Western Blotting to develop a novel screen using the Reck tumour suppressor gene promoter for detecting both conventional and metastasis-suppressing anticancer drugs.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19167904"> <div itemprop="name">Everolimus attenuates neointimal hyperplasia in cultured human saphenous vein grafts.</div> </a> <div itemprop="about">European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery</div> <div itemprop="author">Semsroth S,Stigler RG,Bernecker OY,Ruttmann-Ulmer E,Troppmair J,Macfelda K,Bonatti JO,Laufer G</div> <div itemprop="description">AM4300 was used in western blot to test if mammalian target of rapamycin inhibitor everolimus attenuates neointimal hyperplasia</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18984674"> <div itemprop="name">KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.</div> </a> <div itemprop="about">Physiological genomics</div> <div itemprop="author">Argyropoulos G,Stütz AM,Ilnytska O,Rice T,Teran-Garcia M,Rao DC,Bouchard C,Rankinen T</div> <div itemprop="description">AM4300 was used in western blot to perform a genome-wide linkage scan for endurance training-induced changes in stroke volume</div> <div itemprodp="datePublished">Thu Jan 08 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19409972"> <div itemprop="name">Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies.</div> </a> <div itemprop="about">Experimental gerontology</div> <div itemprop="author">Dasgupta J,Kar S,Van Remmen H,Melendez JA</div> <div itemprop="description">AM4300 was used in western blot to investigate the contribution of reactive oxygen species to the age-dependent increase in collagenase</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19073238"> <div itemprop="name">Molecular cloning and characterization of the common marmoset huntingtin gene.</div> </a> <div itemprop="about">Gene</div> <div itemprop="author">Hohjoh H,Akari H,Fujiwara Y,Tamura Y,Hirai H,Wada K</div> <div itemprop="description">AM4300 was used in western blot to isolate and identify the huntingtin gene of the common marmoset (Callithrix jacchus)</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19413579"> <div itemprop="name">Intracellular signaling pathways control mitochondrial events associated with the development of ischemia/ reperfusion-associated damage.</div> </a> <div itemprop="about">Transplant international : official journal of the European Society for Organ Transplantation</div> <div itemprop="author">Sucher R,Gehwolf P,Kaier T,Hermann M,Maglione M,Oberhuber R,Ratschiller T,Kuznetsov AV,Bösch F,Kozlov AV,Ashraf MI,Schneeberger S,Brandacher G,Ollinger R,Margreiter R,Troppmair J</div> <div itemprop="description">AM4300 was used in Western Blotting to study the activity patterns of ERK, JNK, and p38 during ischaemia-reperfusion, and their role in the perturbation of mitochondrial reactive oxygen species and Ca2+ homeostasis.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19226509"> <div itemprop="name">Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain.</div> </a> <div itemprop="about">The Journal of comparative neurology</div> <div itemprop="author">Judson MC,Bergman MY,Campbell DB,Eagleson KL,Levitt P</div> <div itemprop="description">AM4300 was used in western blot to elucidate the neurodevelopmental influences of Met activation.</div> <div itemprodp="datePublished">Fri Apr 10 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19013219"> <div itemprop="name">Binding of Silurus asotus lectin to Gb3 on Raji cells causes disappearance of membrane-bound form of HSP70.</div> </a> <div itemprop="about">Biochimica et biophysica acta</div> <div itemprop="author">Sugawara S,Kawano T,Omoto T,Hosono M,Tatsuta T,Nitta K</div> <div itemprop="description">AM4300 was used in western blot to study Silurus asotus lectin-induced heat shock protein 70 expression</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19420113"> <div itemprop="name">Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Yu Z,Li M,Zhang D,Xu W,Kone BC</div> <div itemprop="description">AM4300 was used in western blot to test if the -144/-135 Sp element influences basal HKalpha2 gene transcription in murine inner medullary collecting duct cells</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19888333"> <div itemprop="name">C. elegans ATAD-3 is essential for mitochondrial activity and development.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Hoffmann M,Bellance N,Rossignol R,Koopman WJ,Willems PH,Mayatepek E,Bossinger O,Distelmaier F</div> <div itemprop="description">AM4300 was used in western blot to elucidate the function of ATAD3</div> <div itemprodp="datePublished">Fri Oct 30 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18632609"> <div itemprop="name">Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Kano S,Miyajima N,Fukuda S,Hatakeyama S</div> <div itemprop="description">AM4300 was used in western blot to determine the contribution of TRIM32 to carcinogenesis</div> <div itemprodp="datePublished">Tue Jul 15 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18212744"> <div itemprop="name">Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Cuende J,Moreno S,Bolaños JP,Almeida A</div> <div itemprop="description">AM4300 was used in western blot to explore whether retinoic acid promotes differentiation of human SH-SY5Y neuroblastoma cells by modulating Cdh1</div> <div itemprodp="datePublished">Thu May 22 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18212057"> <div itemprop="name">Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targets.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Kuznetsov AV,Smigelskaite J,Doblander C,Janakiraman M,Hermann M,Wurm M,Scheidl SF,Sucher R,Deutschmann A,Troppmair J</div> <div itemprop="description">AM4300 was used in western blot to elucidate how RAF controls cell survival</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17988971"> <div itemprop="name">NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts.</div> </a> <div itemprop="about">Bone</div> <div itemprop="author">Battaglino RA,Pham L,Morse LR,Vokes M,Sharma A,Odgren PR,Yang M,Sasaki H,Stashenko P</div> <div itemprop="description">AM4300 was used in western blot to identify genes upregulated in RANKL-stimulated osteoclast precursor cells</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18685082"> <div itemprop="name">Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.</div> </a> <div itemprop="about">Molecular biology of the cell</div> <div itemprop="author">Inoue H,Ha VL,Prekeris R,Randazzo PA</div> <div itemprop="description">AM4300 was used in western blot to report that the BAR domain of ASAP1 is a protein binding site for FIP3</div> <div itemprodp="datePublished">Wed Oct 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18162042"> <div itemprop="name">GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.</div> </a> <div itemprop="about">PLoS biology</div> <div itemprop="author">Mantel PY,Kuipers H,Boyman O,Rhyner C,Ouaked N,Rückert B,Karagiannidis C,Lambrecht BN,Hendriks RW,Crameri R,Akdis CA,Blaser K,Schmidt-Weber CB</div> <div itemprop="description">AM4300 was used in Western Blot to describe a mechanism controlling inducible Treg polarisation, which is overruled by the Th2 differentiation pathway involving IL-4 and GATA3.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17701361"> <div itemprop="name">Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria.</div> </a> <div itemprop="about">Apoptosis : an international journal on programmed cell death</div> <div itemprop="author">Saelim N,Holstein D,Chocron ES,Camacho P,Lechleiter JD</div> <div itemprop="description">AM4300 was used in western blot to investigate the role of thyroid hormone receptors in apoptosis</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18059158"> <div itemprop="name">BMP suppresses PTEN expression via RAS/ERK signaling.</div> </a> <div itemprop="about">Cancer biology & therapy</div> <div itemprop="author">Beck SE,Carethers JM</div> <div itemprop="description">AM4300 was used in western blot to analyze the effect of bone morphogenetic proteins on PTEN</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16331278"> <div itemprop="name">LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Lu Z,Lam KS,Wang N,Xu X,Cortes M,Andersen B</div> <div itemprop="description">AM4300 was used in western blot to study the involvement of LMO4 in mesenchymal-epithelial signaling</div> <div itemprodp="datePublished">Thu May 11 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16651632"> <div itemprop="name">Galectin-3 expression correlates with apoptosis of tumor-associated lymphocytes in human melanoma biopsies.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Zubieta MR,Furman D,Barrio M,Bravo AI,Domenichini E,Mordoh J</div> <div itemprop="description">AM4300 was used in Western Blotting to investigate 33 biopsies from 24 melanoma patients and describe the correlation between the expression of galectin-3 or galectin-1 and the level of apoptosis of tumor-associated lymphocytes using immunohistochemistry and an in situ nick translation assay.</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2006</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> 38 kDa BFA-dependent ADP-ribosylation substrate; aging-associated gene 9 protein; BARS-38; EC 1.2.1.12; epididymis secretory protein Li 278; epididymis secretory sperm binding protein Li 162eP; GAPDH; GAPDH-2; glceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase type 2; Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; HGNC:4141; MGC88685; multifunctional protein, glycolytic enzyme; Peptidyl-cysteine S-nitrosylase GAPDH; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase; unnamed protein product </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> BARS-38; CDABP0047; G3PD; GAPD; Gapd-s; GAPD2; GAPDH; GAPDH-2; GAPDH2; GAPDHS; GAPDS; HEL-S-162eP; HEL-S-278; HSD-35; HSD35; KNC-NDS6; OK/SW-cl.12 </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/P46406" target="_blank">(Rabbit) P46406</a>, <a href="http://www.uniprot.org/uniprot/P04406" target="_blank">(Human) P04406</a>, <a href="http://www.uniprot.org/uniprot/P00356" target="_blank">(Chicken) P00356</a>, <a href="http://www.uniprot.org/uniprot/O14556" target="_blank">(Human) O14556</a>, <a href="http://www.uniprot.org/uniprot/P16858" target="_blank">(Mouse) P16858</a>, <a href="http://www.uniprot.org/uniprot/P04797" target="_blank">(Rat) P04797</a>, <a href="http://www.uniprot.org/uniprot/Q9ESV6" target="_blank">(Rat) Q9ESV6</a>, <a href="http://www.uniprot.org/uniprot/Q64467" target="_blank">(Mouse) Q64467</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=100009074" target="_blank">(Rabbit) 100009074</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=2597" target="_blank">(Human) 2597</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=374193" target="_blank">(Chicken) 374193</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=403755" target="_blank">(Dog) 403755</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=26330" target="_blank">(Human) 26330</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=476483" target="_blank">(Dog) 476483</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=100352213" target="_blank">(Rabbit) 100352213</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=14433" target="_blank">(Mouse) 14433</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=24383" target="_blank">(Rat) 24383</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=66020" target="_blank">(Rat) 66020</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=14447" target="_blank">(Mouse) 14447</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"> glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity </a> <a class="icon" href="/antibody/primary/panther/protein binding"> protein binding </a> <a class="icon" href="/antibody/primary/panther/microtubule binding"> microtubule binding </a> <a class="icon" href="/antibody/primary/panther/peptidyl-cysteine S-nitrosylase activity"> peptidyl-cysteine S-nitrosylase activity </a> <a class="icon" href="/antibody/primary/panther/identical protein binding"> identical protein binding </a> <a class="icon" href="/antibody/primary/panther/NADP binding"> NADP binding </a> <a class="icon" href="/antibody/primary/panther/NAD binding"> NAD binding </a> <a class="icon" href="/antibody/primary/panther/aspartic-type endopeptidase inhibitor activity"> aspartic-type endopeptidase inhibitor activity </a> <a class="icon" href="/antibody/primary/panther/disordered domain specific binding"> disordered domain specific binding </a> <a class="icon" href="/antibody/primary/panther/molecular_function"> molecular_function </a> <a class="icon" href="/antibody/primary/panther/oxidoreductase activity"> oxidoreductase activity </a> <a class="icon" href="/antibody/primary/panther/oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"> oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor </a> <a class="icon" href="/antibody/primary/panther/dehydrogenase"> dehydrogenase </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/microtubule cytoskeleton organization"> microtubule cytoskeleton organization </a> <a class="icon" href="/antibody/primary/panther/gluconeogenesis"> gluconeogenesis </a> <a class="icon" href="/antibody/primary/panther/regulation of macroautophagy"> regulation of macroautophagy </a> <a class="icon" href="/antibody/primary/panther/negative regulation of translation"> negative regulation of translation </a> <a class="icon" href="/antibody/primary/panther/peptidyl-cysteine S-trans-nitrosylation"> peptidyl-cysteine S-trans-nitrosylation </a> <a class="icon" href="/antibody/primary/panther/protein stabilization"> protein stabilization </a> <a class="icon" href="/antibody/primary/panther/neuron apoptotic process"> neuron apoptotic process </a> <a class="icon" href="/antibody/primary/panther/canonical glycolysis"> canonical glycolysis </a> <a class="icon" href="/antibody/primary/panther/cellular response to interferon-gamma"> cellular response to interferon-gamma </a> <a class="icon" href="/antibody/primary/panther/nuclear membrane fusion"> nuclear membrane fusion </a> <a class="icon" href="/antibody/primary/panther/glycolytic process"> glycolytic process </a> <a class="icon" href="/antibody/primary/panther/negative regulation of endopeptidase activity"> negative regulation of endopeptidase activity </a> <a class="icon" href="/antibody/primary/panther/negative regulation of apoptotic process"> negative regulation of apoptotic process </a> <a class="icon" href="/antibody/primary/panther/positive regulation of cytokine secretion"> positive regulation of cytokine secretion </a> <a class="icon" href="/antibody/primary/panther/defense response to fungus"> defense response to fungus </a> <a class="icon" href="/antibody/primary/panther/killing by host of symbiont cells"> killing by host of symbiont cells </a> <a class="icon" href="/antibody/primary/panther/positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction"> positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction </a> <a class="icon" href="/antibody/primary/panther/oxidation-reduction process"> oxidation-reduction process </a> <a class="icon" href="/antibody/primary/panther/antimicrobial humoral immune response mediated by antimicrobial peptide"> antimicrobial humoral immune response mediated by antimicrobial peptide </a> <a class="icon" href="/antibody/primary/panther/glucose metabolic process"> glucose metabolic process </a> <a class="icon" href="/antibody/primary/panther/regulation of translation"> regulation of translation </a> <a class="icon" href="/antibody/primary/panther/spermatid development"> spermatid development </a> <a class="icon" href="/antibody/primary/panther/sperm motility"> sperm motility </a> <a class="icon" href="/antibody/primary/panther/positive regulation of glycolytic process"> positive regulation of glycolytic process </a> <a class="icon" href="/antibody/primary/panther/carbohydrate metabolic process"> carbohydrate metabolic process </a> <a class="icon" href="/antibody/primary/panther/apoptotic process"> apoptotic process </a> <a class="icon" href="/antibody/primary/panther/multicellular organism development"> multicellular organism development </a> <a class="icon" href="/antibody/primary/panther/response to ammonium ion"> response to ammonium ion </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" src="/order/genome-database/assets/core/js/magellanCore.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadBegin'); </script> <script type="text/javascript" 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