A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2

<!DOCTYPE html> <html lang="en" > <head itemscope itemtype="http://schema.org/WebPage" prefix="og: http://ogp.me/ns#" > <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge">  <meta name="HandheldFriendly" content="True"> <meta name="MobileOptimized" content="320"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="preconnect" href="https://cdn.ncbi.nlm.nih.gov"> <link rel="preconnect" href="https://www.ncbi.nlm.nih.gov"> <link rel="preconnect" href="https://www.google-analytics.com"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.5ecf62baa0fa.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.452c70ce66f7.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.7bf600913d6e.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.0bfa59184c7a.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.b576742ffc3e.css" type="text/css"> <title>A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2 - PubMed</title> <link rel="preload" as="font" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/uswds/dist/fonts/merriweather-bold-webfont.woff2" type="font/woff2" crossorigin />  <link rel="shortcut icon" type="image/ico" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon.ico" /> <link rel="icon" type="image/png" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon.png" />  <link rel="icon" type="image/png" sizes="192x192" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-192.png" />  <link rel="apple-touch-icon-precomposed" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-57.png">  <link rel="apple-touch-icon-precomposed" sizes="72x72" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-72.png">  <link rel="apple-touch-icon-precomposed" sizes="114x114" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-114.png">  <link rel="apple-touch-icon-precomposed" sizes="144x144" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-144.png">  <meta name="ncbi_sg_optimize_id" content="">  <meta name="theme-color" content="#20558a">  <meta name="referrer" content="origin-when-cross-origin"> <meta name="ncbi_pinger_gtm_track" content="true"/>  <meta name="ncbi_app" content="pubmed" /> <meta name="ncbi_db" content="pubmed" /> <meta name="ncbi_phid" content="3C3A00019EBA7315000034590AF8CC60.1.m_6" /> <meta name="ncbi_pinger_stat_url" content="https://www.ncbi.nlm.nih.gov/stat" /> <meta name="log_category" content="literature" /> <meta name="ncbi_cost_center" content="pubmed" />  <meta name="ncbi_pdid" content="abstract" /> <meta name="log_op" content="retrieve" /> <meta name="uid" content="21423366" /> <meta name="ncbi_uid" content="21423366" /> <meta name="log_displayeduids" content="21423366" /> <meta name="log_source_db" content="pubmed,pmc" /> <meta name="log_icons_present" content="true" />  <meta name="description" content="Interactions between membrane proteins and the soluble fraction are essential for signal transduction and for regulating nutrient transport. To gain insights into the membrane-based interactome, 3,852 open reading frames (ORFs) out of a target list of 8,383 representing membrane and signaling protei …"><meta name="keywords" content="pmid:21423366, PMC3059934, doi:10.3389/fphys.2010.00024, Sylvie Lalonde, Antoinette Sero, Wolf B Frommer, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2 - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/21423366/"><meta property="og:description" content="Interactions between membrane proteins and the soluble fraction are essential for signal transduction and for regulating nutrient transport. To gain insights into the membrane-based interactome, 3,852 open reading frames (ORFs) out of a target list of 8,383 representing membrane and signaling protei …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2 - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/21423366/"><meta name="twitter:description" content="Interactions between membrane proteins and the soluble fraction are essential for signal transduction and for regulating nutrient transport. To gain insights into the membrane-based interactome, 3,852 open reading frames (ORFs) out of a target list of 8,383 representing membrane and signaling protei …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/core/no-script.css"> </noscript> <meta name="citation_title" content="A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2"> <meta name="citation_authors" content="Lalonde S;Sero A;Pratelli R;Pilot G;Chen J;Sardi MI;Parsa SA;Kim DY;Acharya BR;Stein EV;Hu HC;Villiers F;Takeda K;Yang Y;Han YS;Schwacke R;Chiang W;Kato N;Loqué D;Assmann SM;Kwak JM;Schroeder JI;Rhee SY;Frommer WB;"> <meta name="citation_date" content="09/22/2010"> <meta name="citation_publisher" content="Front Physiol"> <meta name="citation_journal_title" content="Frontiers in physiology"> <meta name="citation_pmid" content="21423366"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/21423366/"> <meta name="citation_volume" content="1"> <meta name="citation_doi" content="10.3389/fphys.2010.00024"> <meta name="citation_issn" content="1664-042X"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/21423366/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! </div> </div> </div> </noscript> <div class="no-session-banner" id="no-session-banner" hidden> <div class="warning-message"> <div class="warning-message-text"> Clipboard, Search History, and several other advanced features are temporarily unavailable. </div> <button class="close-banner-button" title="Close Clipboard and Search History not available warning banner" ref="linksrc=close_no_session_banner" aria-controls="no-session-banner" aria-label="Close Clipboard and Search History not available warning banner" aria-expanded="true"> </button> </div> </div> <a class="usa-skipnav" href="#article-details"> Skip to main page content </a>  <section class="usa-banner"> <div class="usa-accordion"> <header class="usa-banner-header"> <div class="usa-grid usa-banner-inner"> <img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" /> <p>An official website of the United States government</p> <button class="usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" > <span class="usa-banner-button-text">Here's how you know</span> </button> </div> </header> <div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" > <div class="usa-banner-guidance-gov usa-width-one-half"> <img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" /> <div class="usa-media_block-body"> <p> <strong>The .gov means it’s official.</strong> <br /> Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. </p> </div> </div> <div class="usa-banner-guidance-ssl usa-width-one-half"> <img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" /> <div class="usa-media_block-body"> <p> <strong>The site is secure.</strong> <br /> The <strong>https://</strong> ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. </p> </div> </div> </div> </div> </section> <div class="usa-overlay"></div> <header class="ncbi-header" role="banner" data-section="Header"> <div class="usa-grid"> <div class="usa-width-one-whole"> <div class="ncbi-header__logo"> <a href="https://www.ncbi.nlm.nih.gov/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo"> <img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" /> </a> </div> <div class="ncbi-header__account"> <a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a> <button id="account_info" class="header-button" style="display:none" aria-controls="account_popup"> <span class="fa fa-user" aria-hidden="true"></span> <span class="username desktop-only" aria-hidden="true" id="uname_short"></span> <span class="sr-only">Show account info</span> </button> </div> <div class="ncbi-popup-anchor"> <div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true"> <div class="ncbi-popup-head"> <button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu"><span class="fa fa-times"></span><span class="usa-sr-only">Close</span></button> <h4>Account</h4> </div> <div class="account-user-info"> Logged in as:<br/> <b><span class="username" id="uname_long">username</span></b> </div> <div class="account-links"> <ul class="usa-unstyled-list"> <li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li> <li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li> <li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li> <li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li> </ul> </div> </div> </div> </div> </div> </header> <div role="navigation" aria-label="access keys"> <a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a> <a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a> <a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a> <a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a> <a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a> </div> <section data-section="Alerts"> <div class="ncbi-alerts-placeholder"></div> </section>  <a id="maincontent" aria-label="Main page content below" role="navigation"></a> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <form action="/" method="get" autocomplete="off" class="usa-search usa-search-big search-form content-page-layout" id="search-form" role="search"> <div class="inner-wrap"> <a class="pubmed-logo" aria-label="Pubmed Logo" href="/" data-ga-category="featured_link" data-ga-action="pubmed_logo"> <img src="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/core/images/pubmed-logo-blue.svg" alt="pubmed logo" /> </a> <a href="#" class="search-input-trigger" data-alt-title="Hide search bar" title="Show search bar" aria-label="Show search bar"> </a> <div role="search" class="search-input"> <div class="form-field "> <label class="usa-sr-only" for="id_term"> Search: </label> <input type="search" name="term" data-skip-ie-scroll-to-top="" data-replace-term-with-exact="" data-exact-query="" placeholder="" class="term-input" required="required" id="id_term"/><a href="#" class="clear-btn" aria-label="Clear search input" title="Clear search input" role="button" data-pinger-ignore></a><button type="submit" class="search-btn" aria-label="Search" disabled data-pinger-ignore><span class="usa-search-submit-text">Search</span></button> </div> </div>   <div class="search-links-wrapper content-page-layout"> <div class="search-links"> <a href="/advanced/" class="search-input-link adv-search-link" data-ga-category="featured_link" data-ga-action="adv_search">Advanced</a> <a href="/clipboard/" class="search-input-link clipboard-link hidden" data-ga-category="featured_link" data-ga-action="clipboard"> Clipboard <span class="amount-in-clipboard"></span> </a> </div> <span class="search-input-link user-guide-link" role="navigation" aria-label="User guide"> <a href="/help/" data-ga-category="featured_link" data-ga-action="user_guide"> User Guide </a> </span> </div> </div> </form> <div id="article-page-header"> <div id="article-top-actions-bar" class="article-top-actions-bar"> <div class="inner-wrap"> <div class="actions-container"> <div class="return-to-search"> </div> <div class="multiple-results-actions " role="region" aria-label="save, email, send to"> <button id="save-results-panel-trigger" type="button" class="save-results save-results-panel-trigger" aria-expanded="false" aria-controls="save-action-panel" data-ga-category="save_share" data-ga-action="save" data-ga-label="open"> Save </button><button id="email-results-panel-trigger" type="button" class="email-results email-results-panel-trigger" aria-expanded="false" aria-controls="email-action-panel" data-ga-category="save_share" data-ga-action="email" data-ga-label="open"> Email </button><div class="more-actions dropdown-block"><button id="more-actions-trigger" type="button" class="trigger more-actions-trigger" ref="linksrc=show_moreactions_btn" aria-label="Send to" aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link " href="#" role="button" data-ga-category="save_share" data-ga-action="clipboard" data-ga-label="send"> Clipboard </a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F21423366%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F21423366%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div> </div> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span> <select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format"> <option value="abstract">Abstract</option> <option value="pubmed">PubMed</option> <option value="pmid">PMID</option> </select> </div> </div> </div> </div> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> </div> </div> </div> <div id="article-panels-container" class="article-panels-container"> <div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Save citation to file </h2> <form id="save-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <div class="action-panel-control-wrap"> <label for="save-action-format" class="action-panel-label"> Format: </label> <select id="save-action-format" name="results-format" class="action-panel-selector"> <option value="summary-text">Summary (text)</option> <option value="pubmed-text">PubMed</option> <option value="pmid">PMID</option> <option value="abstract">Abstract (text)</option> <option value="csv">CSV</option> </select> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="save" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Save citations to file' panel" ref="linksrc=close_save_panel" aria-controls="save-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="save" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="email-action-panel" class="email-action-panel action-panel" aria-hidden="true" data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback" data-recaptcha-enabled="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Email citation </h2> <form id="email-action-panel-form" class="action-panel-content action-form" action="/send-email/" data-by-search-action="/results-export-email-by-search-data/" data-by-ids-action="/send-email/" data-by-search-method="post" data-by-ids-method="post" method="post" > <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <div class="action-panel-control-wrap"> <span class="action-panel-label"> Subject: </span> <span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 21423366 - PubMed</span> <input type="hidden" name="email-subject" value="1 selected item: 21423366"/> <input type="hidden" name="email-subject-hash" value="0438d61b8278b702de066cd9fb8162d72783dd049a342873400651b9bb3df4a9"/> </div> <div class="action-panel-control-wrap"> <label for="email-to" class="action-panel-label required-field-asterisk"> To: </label> <input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required> </div> <div class="action-panel-control-wrap"> <label for="email-from" class="action-panel-label"> From: </label> <input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256"> </div> <div class="action-panel-control-wrap"> <label for="email-citation-format" class="action-panel-label"> Format: </label> <select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format"> <option selected="selected" value="summary">Summary</option> <option value="summary-text">Summary (text)</option> <option value="abstract">Abstract</option> <option value="abstract-text">Abstract (text)</option> </select> </div> <div class="include-supplemental-container"> <input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental"> <label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label> </div> <div class="form-field recaptcha "> <div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div> </div> <div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="email" data-ga-label="send"> Send email </button> <button class="action-panel-cancel" aria-label="Close 'Email citations' panel" ref="linksrc=close_email_panel" aria-controls="email-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="email" data-ga-label="cancel"> Cancel </button> </div> <input type="hidden" name="email-search-details" value="" /> <input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" /> </form> </div> </div> <div id="collections-action-panel" class="collections-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-collections-open-panel-enabled="false" data-collections-open-panel-url-hash="#open-collections-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to Collections </h3> <form id="collections-action-panel-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-myncbi-max-collection-name-length="100" data-add-to-collection-max-amount="1000" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <div class="choice-group" role="radiogroup"> <ul class="radio-group-items"> <li> <input type="radio" id="collections-action-panel-new" class="collections-new" name="collections" value="new" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_new"> <label for="collections-action-panel-new">Create a new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="21423366"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="https://doi.org/10.3389/fphys.2010.00024" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=6956&itool=Abstract-def&log$=linkouticon&uid=21423366&db=pubmed&nlmid=101549006" title="See full text options at Frontiers Media SA" data-ga-category="full_text" data-ga-action="Frontiers Media SA" data-ga-label="21423366" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.frontiersin.org-alerts-logo-PubMed.png" alt="full text provider logo"><span class="text"> Frontiers Media SA </span></a><a class="link-item pmc " href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/21423366/" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=21423366&db=pubmed&nlmid=101549006" title="Free full text at PubMed Central" data-ga-category="full_text" data-ga-action="PMC" data-ga-label="21423366" ><span class="text"> Free PMC article </span></a> </div> </div> <div class="short-view"> <a href="#" class="full-text-links-button full-text-links-dialog-trigger"> Full text links </a> </div> </div> <div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/21423366/citations/" data-citation-style="nlm" data-pubmed-format-link="/21423366/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="21423366" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger" aria-label="Save article in MyNCBI collections." data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_button" data-collections-open-dialog-enabled="false" data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F21423366%2F%23open-collections-dialog" data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog" class="dialog collections-dialog" aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="sidebar-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="social-sharing"> <h3 class="title"> Share </h3> <ul class="social-sharing-links usa-unstyled-list"> <li> <a href="http://twitter.com/intent/tweet?text=A%20membrane%20protein/signaling%20protein%20interaction%20network%20for%20Arabidopsis%20version%20AMPv2%20https%3A//pubmed.ncbi.nlm.nih.gov/21423366/" class="share-link share-link-twitter" rel="noreferrer noopener" target="Pubmed-Social-Media-Share-Popup" title="Share article on Twitter" data-ga-category="save_share" data-ga-action="social" data-ga-label="twitter"></a> </li> <li> <a href="http://www.facebook.com/sharer/sharer.php?u=https%3A//pubmed.ncbi.nlm.nih.gov/21423366/" class="share-link share-link-facebook" rel="noreferrer noopener" target="Pubmed-Social-Media-Share-Popup" title="Share article on Facebook" data-ga-category="save_share" data-ga-action="social" data-ga-label="fb"></a> </li> <li> <div class="share-permalink"> <button class="trigger" title="Show article permalink" ref="linksrc=show_permalink_btn"> </button> <div class="dropdown" hidden> <div class="title"> Permalink </div> <div class="content"> <input type="text" class="permalink-text" value="https://pubmed.ncbi.nlm.nih.gov/21423366/" aria-label="Article permalink"/><button class="permalink-copy-button usa-button-primary" title="Copy article permalink" data-ga-category="save_share" data-ga-action="link" data-ga-label="copy_link"><span class="button-title">Copy</span></button> </div> </div> </div> </li> </ul> </div> <nav class="page-navigator" role="navigation" aria-label="Page navigation"> <div class="full-view"> <h3 class="title"> Page navigation </h3> <ul class="items-list"> <li class="heading "> <a href="#heading" aria-label="navigate to Title & authors section" data-ga-category="page_nav" data-ga-action="heading"> Title & authors </a> </li> <li class="abstract "> <a href="#abstract" aria-label="navigate to Abstract section" data-ga-category="page_nav" data-ga-action="abstract"> Abstract </a> </li> <li class="figures "> <a href="#figures" aria-label="navigate to Figures section" data-ga-category="page_nav" data-ga-action="figures"> Figures </a> </li> <li class="similar "> <a href="#similar" aria-label="navigate to Similar articles section" data-ga-category="page_nav" data-ga-action="similar"> Similar articles </a> </li> <li class="citedby "> <a href="#citedby" aria-label="navigate to Cited by section" data-ga-category="page_nav" data-ga-action="citedby"> Cited by </a> </li> <li class="references "> <a href="#references" aria-label="navigate to References section" data-ga-category="page_nav" data-ga-action="references"> References </a> </li> <li class="related-links "> <a href="#related-links" aria-label="navigate to Related information section" data-ga-category="page_nav" data-ga-action="related-links"> Related information </a> </li> <li class="linkout "> <a href="#linkout" aria-label="navigate to LinkOut - more resources section" data-ga-category="page_nav" data-ga-action="linkout"> LinkOut - more resources </a> </li> </ul> </div> <select class="short-view" autocomplete="off" title="navigate to selected section" aria-label="Navigate to page section"> <option value="heading">Title & authors</option> <option value="abstract">Abstract</option> <option value="figures">Figures</option> <option value="similar">Similar articles</option> <option value="citedby">Cited by</option> <option value="references">References</option> <option value="related-links">Related information</option> <option value="linkout">LinkOut - more resources</option> </select> </nav> </div> </aside> <main class="article-details" id="article-details">   <header class="heading" id="heading"> <div class="full-view" id="full-view-heading"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Frontiers in physiology" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Frontiers in physiology" data-pinger-ignore> Front Physiol </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Frontiers in physiology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Front+Physiol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Front+Physiol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Front Physiol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Front Physiol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Front+Physiol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Front Physiol"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Front Physiol"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Front Physiol"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2010 Sep 22:1:24.</span> </div> <span class="citation-doi"> doi: 10.3389/fphys.2010.00024. </span> <span class="secondary-date"> eCollection 2010. </span> </div> <h1 class="heading-title"> A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2 </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Lalonde+S&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sylvie Lalonde">Sylvie Lalonde</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Plant Biology, Carnegie Institution for Science Stanford, CA, USA. slalonde@stanford.edu" href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sero+A&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Antoinette Sero">Antoinette Sero</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pratelli+R&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Réjane Pratelli">Réjane Pratelli</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pilot+G&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Guillaume Pilot">Guillaume Pilot</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chen+J&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jin Chen">Jin Chen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sardi+MI&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Maria I Sardi">Maria I Sardi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Parsa+SA&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Saman A Parsa">Saman A Parsa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kim+DY&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Do-Young Kim">Do-Young Kim</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Acharya+BR&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Biswa R Acharya">Biswa R Acharya</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stein+EV&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Erica V Stein">Erica V Stein</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hu+HC&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Heng-Chen Hu">Heng-Chen Hu</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Villiers+F&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Florent Villiers">Florent Villiers</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Takeda+K&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kouji Takeda">Kouji Takeda</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yang+Y&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yingzhen Yang">Yingzhen Yang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Han+YS&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yong S Han">Yong S Han</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schwacke+R&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rainer Schwacke">Rainer Schwacke</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chiang+W&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="William Chiang">William Chiang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kato+N&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Naohiro Kato">Naohiro Kato</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Loqu%C3%A9+D&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dominique Loqué">Dominique Loqué</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Assmann+SM&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sarah M Assmann">Sarah M Assmann</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kwak+JM&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="June M Kwak">June M Kwak</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schroeder+JI&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Julian I Schroeder">Julian I Schroeder</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rhee+SY&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Seung Y Rhee">Seung Y Rhee</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Frommer+WB&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wolf B Frommer">Wolf B Frommer</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/21423366/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Department of Plant Biology, Carnegie Institution for Science Stanford, CA, USA. slalonde@stanford.edu</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">21423366</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC3059934&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3059934/" data-ga-category="full_text" data-ga-action="PMCID" > PMC3059934 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.3389/fphys.2010.00024&id_type=DOI" href="https://doi.org/10.3389/fphys.2010.00024" data-ga-category="full_text" data-ga-action="DOI" > 10.3389/fphys.2010.00024 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2 </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Sylvie Lalonde</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Front Physiol<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2010">2010</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/21423366/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span> <select name="format" data-initial-value="abstract" aria-label="Display format" id="mobile-display-format"> <option value="abstract">Abstract</option> <option value="pubmed">PubMed</option> <option value="pmid">PMID</option> </select> </div> </div> </div> </div> </div> <div class="extended-article-details" id="full-article-details" aria-hidden="true"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Frontiers in physiology" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Frontiers in physiology" data-pinger-ignore> Front Physiol </button><div id="short-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Frontiers in physiology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Front+Physiol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Front+Physiol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Front Physiol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Front Physiol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Front+Physiol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Front Physiol"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Front Physiol"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Front Physiol"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2010 Sep 22:1:24.</span> </div> <span class="citation-doi"> doi: 10.3389/fphys.2010.00024. </span> <span class="secondary-date"> eCollection 2010. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Lalonde+S&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sylvie Lalonde">Sylvie Lalonde</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Plant Biology, Carnegie Institution for Science Stanford, CA, USA. slalonde@stanford.edu" href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sero+A&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Antoinette Sero">Antoinette Sero</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pratelli+R&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Réjane Pratelli">Réjane Pratelli</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pilot+G&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Guillaume Pilot">Guillaume Pilot</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chen+J&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jin Chen">Jin Chen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sardi+MI&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Maria I Sardi">Maria I Sardi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Parsa+SA&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Saman A Parsa">Saman A Parsa</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kim+DY&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Do-Young Kim">Do-Young Kim</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Acharya+BR&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Biswa R Acharya">Biswa R Acharya</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stein+EV&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Erica V Stein">Erica V Stein</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hu+HC&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Heng-Chen Hu">Heng-Chen Hu</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Villiers+F&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Florent Villiers">Florent Villiers</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Takeda+K&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kouji Takeda">Kouji Takeda</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yang+Y&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yingzhen Yang">Yingzhen Yang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Han+YS&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yong S Han">Yong S Han</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schwacke+R&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rainer Schwacke">Rainer Schwacke</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chiang+W&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="William Chiang">William Chiang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kato+N&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Naohiro Kato">Naohiro Kato</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Loqu%C3%A9+D&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dominique Loqué">Dominique Loqué</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Assmann+SM&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sarah M Assmann">Sarah M Assmann</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kwak+JM&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="June M Kwak">June M Kwak</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schroeder+JI&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Julian I Schroeder">Julian I Schroeder</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rhee+SY&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Seung Y Rhee">Seung Y Rhee</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Frommer+WB&cauthor_id=21423366" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wolf B Frommer">Wolf B Frommer</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Plant Biology, Carnegie Institution for Science Stanford, CA, USA. slalonde@stanford.edu</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">21423366</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC3059934&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3059934/" data-ga-category="full_text" data-ga-action="PMCID" > PMC3059934 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.3389/fphys.2010.00024&id_type=DOI" href="https://doi.org/10.3389/fphys.2010.00024" data-ga-category="full_text" data-ga-action="DOI" > 10.3389/fphys.2010.00024 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/21423366/citations/" data-citation-style="nlm" data-pubmed-format-link="/21423366/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Interactions between membrane proteins and the soluble fraction are essential for signal transduction and for regulating nutrient transport. To gain insights into the membrane-based interactome, 3,852 open reading frames (ORFs) out of a target list of 8,383 representing membrane and signaling proteins from Arabidopsis thaliana were cloned into a Gateway-compatible vector. The mating-based split ubiquitin system was used to screen for potential protein-protein interactions (pPPIs) among 490 Arabidopsis ORFs. A binary robotic screen between 142 receptor-like kinases (RLKs), 72 transporters, 57 soluble protein kinases and phosphatases, 40 glycosyltransferases, 95 proteins of various functions, and 89 proteins with unknown function detected 387 out of 90,370 possible PPIs. A secondary screen confirmed 343 (of 386) pPPIs between 179 proteins, yielding a scale-free network (r(2) = 0.863). Eighty of 142 transmembrane RLKs tested positive, identifying 3 homomers, 63 heteromers, and 80 pPPIs with other proteins. Thirty-one out of 142 RLK interactors (including RLKs) had previously been found to be phosphorylated; thus interactors may be substrates for respective RLKs. None of the pPPIs described here had been reported in the major interactome databases, including potential interactors of G-protein-coupled receptors, phospholipase C, and AMT ammonium transporters. Two RLKs found as putative interactors of AMT1;1 were independently confirmed using a split luciferase assay in Arabidopsis protoplasts. These RLKs may be involved in ammonium-dependent phosphorylation of the C-terminus and regulation of ammonium uptake activity. The robotic screening method established here will enable a systematic analysis of membrane protein interactions in fungi, plants and metazoa. </p> </div> <p> <strong class="sub-title"> Keywords: </strong> kinase; phosphorylation; protein interaction; receptor; split ubiquitin system; transport; yeast two hybrid. </p> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/a1e5e37afbea/fphys-01-00024-g001.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="565" data-image-height="713" data-image-alt="Figure 1" data-pmc-id="PMC3059934" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/585c3c9d4233/fphys-01-00024-g001.gif" alt="Figure 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="565"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="713"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><b> Outline of the cloning and… </b></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><b> Outline of the cloning and mbSUS screen </b> . Selected ORFs were amplified from…</div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1 </strong> <div class="figure-caption-contents"><b>Outline of the cloning and mbSUS screen</b>. Selected ORFs were amplified from <i>Arabidopsis</i> seedling cDNA and cloned into pDONR221 (or pDONR221-f1) by Gateway recombination. ORFs that passed the quality control criteria were mobilized into Cub and NubG destination vectors and introduced into THY.AP4 and THY.AP5 yeast strains. Yeast expressing the Cub clones were pre-screened to remove “false positives” and “false negatives.” Remaining Cub clones were mated with NubG clones that had been arrayed into two 1536-well plates. Successful mating was selected on DS media. After 3 days, diploids were replica-plated to IS media selecting for activation of the His3 and Ade2 markers and growth was scored.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/4cf84d7e7f31/fphys-01-00024-g002.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="490" data-image-height="1020" data-image-alt="Figure 2" data-pmc-id="PMC3059934" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/db9f2528cef3/fphys-01-00024-g002.gif" alt="Figure 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="490"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1020"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><b> pPPIs detected in the AMPv2… </b></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><b> pPPIs detected in the AMPv2 screen </b> . <b> (A) </b> Selection of diploid cells on…</div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2 </strong> <div class="figure-caption-contents"><b>pPPIs detected in the AMPv2 screen</b>. <b>(A)</b> Selection of diploid cells on DS media supplemented with adenine and histidine. <b>(B)</b> Successful mating (His3, Ade2 positive) was selected on IS-0 media without met (right) and IS-500 with 500 μM met (left). <b>(C)</b> Representative image of the β-galactosidase assay performed on yeast grown on nitrocellulose-overlaid agar media. Positive pairs were picked by hand, re-arrayed and tested for the LacZ marker. Plate size for <b>(A–C)</b> was 125 mm × 85 mm.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/99b28f22ed10/fphys-01-00024-g003.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="567" data-image-height="517" data-image-alt="Figure 3" data-pmc-id="PMC3059934" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/efed8958e026/fphys-01-00024-g003.gif" alt="Figure 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="567"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="517"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><b> AMPv2 pPPI network </b> . Network…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><b> AMPv2 pPPI network </b> . Network of all pairs with a positive read-out for…</div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 3 </strong> <div class="figure-caption-contents"><b>AMPv2 pPPI network</b>. Network of all pairs with a positive read-out for all three markers as visualized in Cytoscape. The network comprises 179 nodes and 343 edges. Symbol color corresponds to degree of interactions (color code on the left). Symbol shape indicates protein function (code at the top).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="figure-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/cf8ef38fd422/fphys-01-00024-g004.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="406" data-image-height="749" data-image-alt="Figure 4" data-pmc-id="PMC3059934" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/df0ab2ff1c21/fphys-01-00024-g004.gif" alt="Figure 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="406"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="749"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 4 </p> </strong> <div class="figure-caption-contents"><b> Representation of Nub and Cub… </b></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 4 </p> </strong> <div class="figure-caption-contents"><b> Representation of Nub and Cub clones in AMPv2 network and frequency distribution of… </b></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 4 </strong> <div class="figure-caption-contents"><b>Representation of Nub and Cub clones in AMPv2 network and frequency distribution of the resulting network</b>. <b>(A)</b> The mbSUS screen was performed with 490 genes of which 443 were mobilized into the Nub destination vector and 204 into the Cub destination vector (157 genes were common to both pools). The pPPI network between 179 nodes yielded 343 edges. <b>(B)</b> The power law frequency distribution of the network was obtained with the “NetworkAnalysis” tool of Cytoscape.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="figure-5"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/f12ad62c193d/fphys-01-00024-g005.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="567" data-image-height="514" data-image-alt="Figure 5" data-pmc-id="PMC3059934" data-figure-id="F5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/4dd995d10bb8/fphys-01-00024-g005.gif" alt="Figure 5" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="567"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="514"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 5 </p> </strong> <div class="figure-caption-contents"><b> Sub-network of receptor kinase interactions… </b></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 5 </p> </strong> <div class="figure-caption-contents"><b> Sub-network of receptor kinase interactions (RLK) </b> . Labeling as in Figure 3. The…</div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 5 </strong> <div class="figure-caption-contents"><b>Sub-network of receptor kinase interactions (RLK)</b>. Labeling as in Figure 3. The blue borders surrounding 31 individual RLKs indicate evidence for phosphorylated sites according to PhosPhAt 3.0 (Durek et al., 2010).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="5" data-label-slug="figure-6"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/b7ac1dee6f69/fphys-01-00024-g006.jpg" itemprop="contentUrl" aria-describedby="figure-caption-5" role="button" data-image-width="490" data-image-height="718" data-image-alt="Figure 6" data-pmc-id="PMC3059934" data-figure-id="F6"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-5" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/6c8960c008e3/fphys-01-00024-g006.gif" alt="Figure 6" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="490"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="718"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 6 </p> </strong> <div class="figure-caption-contents"><b> Sub-network of 7TM receptors </b> .…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 6 </p> </strong> <div class="figure-caption-contents"><b> Sub-network of 7TM receptors </b> . <b> (A) </b> Members of the MLO receptor family are…</div> </div> <figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 6 </strong> <div class="figure-caption-contents"><b>Sub-network of 7TM receptors</b>. <b>(A)</b> Members of the MLO receptor family are displayed as a sub-network. <b>(B)</b> GCR1 sub-network (AT1G48270). Labeling as in Figure 5.</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="6" data-label-slug="figure-7"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/21de867e9893/fphys-01-00024-g007.jpg" itemprop="contentUrl" aria-describedby="figure-caption-6" role="button" data-image-width="453" data-image-height="325" data-image-alt="Figure 7" data-pmc-id="PMC3059934" data-figure-id="F7"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-6" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/cb7f6d894600/fphys-01-00024-g007.gif" alt="Figure 7" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="453"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="325"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 7 </p> </strong> <div class="figure-caption-contents"><b> Sub-network of calcium ATPases, phospholipase… </b></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 7 </p> </strong> <div class="figure-caption-contents"><b> Sub-network of calcium ATPases, phospholipase C2 and aquaporins </b> . <b> (A) </b> ACA12 sub-network (AT3G63380),…</div> </div> <figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 7 </strong> <div class="figure-caption-contents"><b>Sub-network of calcium ATPases, phospholipase C2 and aquaporins</b>. <b>(A)</b> ACA12 sub-network (AT3G63380), <b>(B)</b> PLC2 sub-network (AT3G08510), and <b>(C)</b> aquaporin sub-network. Labeling as in Figure 5.</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="7" data-label-slug="figure-8"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/b61405b0c88a/fphys-01-00024-g008.jpg" itemprop="contentUrl" aria-describedby="figure-caption-7" role="button" data-image-width="564" data-image-height="256" data-image-alt="Figure 8" data-pmc-id="PMC3059934" data-figure-id="F8"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-7" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e86/3059934/7c7f3c138ab2/fphys-01-00024-g008.gif" alt="Figure 8" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="564"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="256"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 8 </p> </strong> <div class="figure-caption-contents"><b> Ammonium transporter sub-network </b> . <b> (A)… </b></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 8 </p> </strong> <div class="figure-caption-contents"><b> Ammonium transporter sub-network </b> . <b> (A) </b> AMT1;1 sub-network (AT4G13510). Labeling as in Figure 5.…</div> </div> <figcaption id="figure-caption-7" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 8 </strong> <div class="figure-caption-contents"><b>Ammonium transporter sub-network</b>. <b>(A)</b> AMT1;1 sub-network (AT4G13510). Labeling as in Figure 5. <b>(B)</b> Independent analysis of AMT1;1 interaction with two RLKs identified in AMPv2 using the split luciferase assay in <i>Arabidopsis</i> leaf protoplasts. Red asterisks in the diagram to the right indicate the position of the split luciferase fusions.</div> </figcaption> </figure> </div> <div class="see-all actions-bar"> <button class="show-more" aria-controls="slides-container" data-ga-category="figure" data-ga-action="show_all"> All figures (8) </button> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/26414709/" ref="article_id=26414709&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="26414709" data-ga-label=""> Heterotrimeric G proteins interact with defense-related receptor-like kinases in Arabidopsis. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Aranda-Sicilia MN, Trusov Y, Maruta N, Chakravorty D, Zhang Y, Botella JR.</span> <span class="docsum-authors short-authors">Aranda-Sicilia MN, et al.</span> <span class="docsum-journal-citation full-journal-citation">J Plant Physiol. 2015 Sep 1;188:44-8. doi: 10.1016/j.jplph.2015.09.005. Epub 2015 Sep 24.</span> <span class="docsum-journal-citation short-journal-citation">J Plant Physiol. 2015.</span> <span class="citation-part">PMID: <span class="docsum-pmid">26414709</span></span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/32503273/" ref="article_id=32503273&linksrc=similar_articles_link&ordinalpos=2" data-ga-category="similar_article" data-ga-action="32503273" data-ga-label=""> Arabidopsis Transmembrane Receptor-Like Kinases (RLKs): A Bridge between Extracellular Signal and Intracellular Regulatory Machinery. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Jose J, Ghantasala S, Roy Choudhury S.</span> <span class="docsum-authors short-authors">Jose J, et al.</span> <span class="docsum-journal-citation full-journal-citation">Int J Mol Sci. 2020 Jun 3;21(11):4000. doi: 10.3390/ijms21114000.</span> <span class="docsum-journal-citation short-journal-citation">Int J Mol Sci. 2020.</span> <span class="citation-part">PMID: <span class="docsum-pmid">32503273</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> <span class="publication-type spaced-citation-item citation-part">Review.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/29361797/" ref="article_id=29361797&linksrc=similar_articles_link&ordinalpos=3" data-ga-category="similar_article" data-ga-action="29361797" data-ga-label=""> Biochemical Analysis of the Role of Leucine-Rich Repeat Receptor-Like Kinases and the Carboxy-Terminus of Receptor Kinases in Regulating Kinase Activity in Arabidopsis thaliana and Brassica oleracea. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Oh ES, Lee Y, Chae WB, Rameneni JJ, Park YS, Lim YP, Oh MH.</span> <span class="docsum-authors short-authors">Oh ES, et al.</span> <span class="docsum-journal-citation full-journal-citation">Molecules. 2018 Jan 22;23(1):236. doi: 10.3390/molecules23010236.</span> <span class="docsum-journal-citation short-journal-citation">Molecules. 2018.</span> <span class="citation-part">PMID: <span class="docsum-pmid">29361797</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/24833385/" ref="article_id=24833385&linksrc=similar_articles_link&ordinalpos=4" data-ga-category="similar_article" data-ga-action="24833385" data-ga-label=""> Border control--a membrane-linked interactome of Arabidopsis. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Jones AM, Xuan Y, Xu M, Wang RS, Ho CH, Lalonde S, You CH, Sardi MI, Parsa SA, Smith-Valle E, Su T, Frazer KA, Pilot G, Pratelli R, Grossmann G, Acharya BR, Hu HC, Engineer C, Villiers F, Ju C, Takeda K, Su Z, Dong Q, Assmann SM, Chen J, Kwak JM, Schroeder JI, Albert R, Rhee SY, Frommer WB.</span> <span class="docsum-authors short-authors">Jones AM, et al.</span> <span class="docsum-journal-citation full-journal-citation">Science. 2014 May 16;344(6185):711-6. doi: 10.1126/science.1251358.</span> <span class="docsum-journal-citation short-journal-citation">Science. 2014.</span> <span class="citation-part">PMID: <span class="docsum-pmid">24833385</span></span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/38174365/" ref="article_id=38174365&linksrc=similar_articles_link&ordinalpos=5" data-ga-category="similar_article" data-ga-action="38174365" data-ga-label=""> Receptor-like kinases and their signaling cascades for plant male fertility: loyal messengers. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Zhu L, Li F, Xie T, Li Z, Tian T, An X, Wei X, Long Y, Jiao Z, Wan X.</span> <span class="docsum-authors short-authors">Zhu L, et al.</span> <span class="docsum-journal-citation full-journal-citation">New Phytol. 2024 Feb;241(4):1421-1434. doi: 10.1111/nph.19527. Epub 2024 Jan 4.</span> <span class="docsum-journal-citation short-journal-citation">New Phytol. 2024.</span> <span class="citation-part">PMID: <span class="docsum-pmid">38174365</span></span> <span class="publication-type spaced-citation-item citation-part">Review.</span> </div> </div> </li> </ul> <div class="actions-bar"> <a class="show-all-linked-articles" data-href="/?linkname=pubmed_pubmed&from_uid=21423366" data-ga-category="similar_article" data-ga-action="show_all" > See all similar articles </a> </div> </div> <div class="citedby-articles" id="citedby"> <h2 class="title"> Cited by </h2> <ul class="articles-list" id="citedby-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/39233915/" ref="article_id=39233915&linksrc=citedby_articles_link&ordinalpos=1" data-ga-category="cited_by" data-ga-action="39233915" data-ga-label=""> Research progress and application strategies of sugar transport mechanisms in rice. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Li J, He C, Liu S, Guo Y, Zhang Y, Zhang L, Zhou X, Xu D, Luo X, Liu H, Yang X, Wang Y, Shi J, Yang B, Wang J, Wang P, Deng X, Sun C.</span> <span class="docsum-authors short-authors">Li J, et al.</span> <span class="docsum-journal-citation full-journal-citation">Front Plant Sci. 2024 Aug 21;15:1454615. doi: 10.3389/fpls.2024.1454615. eCollection 2024.</span> <span class="docsum-journal-citation short-journal-citation">Front Plant Sci. 2024.</span> <span class="citation-part">PMID: <span class="docsum-pmid">39233915</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> <span class="publication-type spaced-citation-item citation-part">Review.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/37052186/" ref="article_id=37052186&linksrc=citedby_articles_link&ordinalpos=2" data-ga-category="cited_by" data-ga-action="37052186" data-ga-label=""> A cornichon protein controls polar localization of the PINA auxin transporter in Physcomitrium patens. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Yáñez-Domínguez C, Lagunas-Gómez D, Torres-Cifuentes DM, Bezanilla M, Pantoja O.</span> <span class="docsum-authors short-authors">Yáñez-Domínguez C, et al.</span> <span class="docsum-journal-citation full-journal-citation">Development. 2023 May 1;150(9):dev201635. doi: 10.1242/dev.201635. Epub 2023 May 5.</span> <span class="docsum-journal-citation short-journal-citation">Development. 2023.</span> <span class="citation-part">PMID: <span class="docsum-pmid">37052186</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/36982308/" ref="article_id=36982308&linksrc=citedby_articles_link&ordinalpos=3" data-ga-category="cited_by" data-ga-action="36982308" data-ga-label=""> The <em>Phaseolus vulgaris</em> Receptor-Like Kinase PvFER1 and the Small Peptides PvRALF1 and PvRALF6 Regulate Nodule Number as a Function of Nitrate Availability. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Solís-Miranda J, Juárez-Verdayes MA, Nava N, Rosas P, Leija-Salas A, Cárdenas L, Quinto C.</span> <span class="docsum-authors short-authors">Solís-Miranda J, et al.</span> <span class="docsum-journal-citation full-journal-citation">Int J Mol Sci. 2023 Mar 9;24(6):5230. doi: 10.3390/ijms24065230.</span> <span class="docsum-journal-citation short-journal-citation">Int J Mol Sci. 2023.</span> <span class="citation-part">PMID: <span class="docsum-pmid">36982308</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/36651113/" ref="article_id=36651113&linksrc=citedby_articles_link&ordinalpos=4" data-ga-category="cited_by" data-ga-action="36651113" data-ga-label=""> The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Lagunas-Gomez D, Yañez-Dominguez C, Zavala-Padilla G, Barlowe C, Pantoja O.</span> <span class="docsum-authors short-authors">Lagunas-Gomez D, et al.</span> <span class="docsum-journal-citation full-journal-citation">J Cell Sci. 2023 Feb 1;136(3):jcs260527. doi: 10.1242/jcs.260527. Epub 2023 Feb 6.</span> <span class="docsum-journal-citation short-journal-citation">J Cell Sci. 2023.</span> <span class="citation-part">PMID: <span class="docsum-pmid">36651113</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/36495424/" ref="article_id=36495424&linksrc=citedby_articles_link&ordinalpos=5" data-ga-category="cited_by" data-ga-action="36495424" data-ga-label=""> MATE transporter GFD1 cooperates with sugar transporters, mediates carbohydrate partitioning and controls grain-filling duration, grain size and number in rice. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Sun C, Wang Y, Yang X, Tang L, Wan C, Liu J, Chen C, Zhang H, He C, Liu C, Wang Q, Zhang K, Zhang W, Yang B, Li S, Zhu J, Sun Y, Li W, Zhou Y, Wang P, Deng X.</span> <span class="docsum-authors short-authors">Sun C, et al.</span> <span class="docsum-journal-citation full-journal-citation">Plant Biotechnol J. 2023 Mar;21(3):621-634. doi: 10.1111/pbi.13976. Epub 2022 Dec 29.</span> <span class="docsum-journal-citation short-journal-citation">Plant Biotechnol J. 2023.</span> <span class="citation-part">PMID: <span class="docsum-pmid">36495424</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> </ul> <div class="actions-bar"> <a class="show-all-linked-articles" data-href="/?linkname=pubmed_pubmed_citedin&from_uid=21423366" data-ga-category="cited_by" data-ga-action="show_all" > See all "Cited by" articles </a> </div> </div> <div class="references" id="references"> <h2 class="title"> References </h2> <div id='top-references-list' class="references-lists-container"> <div class="refs-list"> <ol id="top-references-list-1" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Adams A., Gottschling D. E., Kaiser C. A., Stearns T. (1998). Methods in Yeast Genetics. New York: Cold Spring Harbor Laboratory Press </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Assenov Y., Ramirez F., Schelhorn S. E., Lengauer T., Albrecht M. (2008). Computing topological parameters of biological networks. Bioinformatics 24, 282–28410.1093/bioinformatics/btm554 - <a class="reference-link" href="https://doi.org/10.1093/bioinformatics/btm554" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1093/bioinformatics/btm554" > DOI </a> - <a class="reference-link" href="/18006545/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="18006545" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Bauer S., Grossmann S., Vingron M., Robinson P. N. (2008). Ontologizer 2.0 – a multifunctional tool for GO term enrichment analysis and data exploration. Bioinformatics 24, 1650–165110.1093/bioinformatics/btn250 - <a class="reference-link" href="https://doi.org/10.1093/bioinformatics/btn250" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1093/bioinformatics/btn250" > DOI </a> - <a class="reference-link" href="/18511468/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="18511468" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Bernsel A., Viklund H., Hennerdal A., Elofsson A. (2009). TOPCONS: consensus prediction of membrane protein topology. Nucleic Acids Res. 37, W465–W46810.1093/nar/gkp363 - <a class="reference-link" href="https://doi.org/10.1093/nar/gkp363" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1093/nar/gkp363" > DOI </a> - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2703981/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="PMC2703981" > PMC </a> - <a class="reference-link" href="/19429891/" ref="linksrc=references_link&ordinalpos=3" data-ga-category="reference" data-ga-action="19429891" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Boursiac Y., Harper J. F. (2007). The origin and function of calmodulin regulated Ca2+ pumps in plants. J. Bioenerg. Biomembr. 39, 409–41410.1007/s10863-007-9104-z - <a class="reference-link" href="https://doi.org/10.1007/s10863-007-9104-z" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1007/s10863-007-9104-z" > DOI </a> - <a class="reference-link" href="/18000746/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="18000746" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-1" data-next-page-url="/21423366/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 59 references </button> </div> </div> </div> </div> <div id="related-links" class="related-links"> <h2 class="title"> Related information </h2> <ul class="related-links-list"><li><a title="Link to related Genes" href="https://www.ncbi.nlm.nih.gov/gene?linkname=pubmed_gene&from_uid=21423366" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=21423366&ordinalpos=1&linkpos=1"> Gene </a></li><li><a title="Published Nucleotide sequences" href="https://www.ncbi.nlm.nih.gov/nuccore?linkname=pubmed_nuccore&from_uid=21423366" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=21423366&ordinalpos=1&linkpos=2"> Nucleotide </a></li><li><a title="Published protein sequences" href="https://www.ncbi.nlm.nih.gov/protein?linkname=pubmed_protein&from_uid=21423366" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=21423366&ordinalpos=1&linkpos=3"> Protein </a></li><li><a title="Link to Protein RefSeqs" href="https://www.ncbi.nlm.nih.gov/protein?linkname=pubmed_protein_refseq&from_uid=21423366" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=21423366&ordinalpos=1&linkpos=4"> Protein (RefSeq) </a></li><li><a title="Related PubChem Compound" href="https://www.ncbi.nlm.nih.gov/pccompound?linkname=pubmed_pccompound&from_uid=21423366" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=21423366&ordinalpos=1&linkpos=5"> PubChem Compound </a></li><li><a title="Related PubChem Substance" href="https://www.ncbi.nlm.nih.gov/pcsubstance?linkname=pubmed_pcsubstance&from_uid=21423366" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=21423366&ordinalpos=1&linkpos=6"> PubChem Substance </a></li></ul> </div> <div id="linkout" class="linkout"> <h2 class="title"> LinkOut - more resources </h2> <ul class="linkout-list"><li><h3 class="linkout-category">Full Text Sources</h3><ul class="linkout-category-links"><li><a href="https://europepmc.org/abstract/MED/21423366" target="_blank" rel="noopener" ref="linksrc=linkout_link&PrId=6082&uid=21423366&db=pubmed&itool=Abstract&log$=linkoutlink&nlmid=101549006" data-ga-category="link_out" data-ga-action="Full Text Sources" data-ga-label="Europe PubMed Central" > Europe PubMed Central </a></li><li><a href="https://doi.org/10.3389/fphys.2010.00024" target="_blank" rel="noopener" ref="linksrc=linkout_link&PrId=6956&uid=21423366&db=pubmed&itool=Abstract&log$=linkoutlink&nlmid=101549006" data-ga-category="link_out" data-ga-action="Full Text Sources" data-ga-label="Frontiers Media SA" > Frontiers Media SA </a></li><li><a href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/21423366/" target="_blank" rel="noopener" ref="linksrc=linkout_link&PrId=3494&uid=21423366&db=pubmed&itool=Abstract&log$=linkoutlink&nlmid=101549006" data-ga-category="link_out" data-ga-action="Full Text Sources" data-ga-label="PubMed Central" > PubMed Central </a></li></ul></li><li><h3 class="linkout-category">Molecular Biology Databases</h3><ul class="linkout-category-links"><li><a href="http://amigo.geneontology.org/amigo/reference/PMID:21423366" target="_blank" rel="noopener" ref="linksrc=linkout_link&PrId=9516&uid=21423366&db=pubmed&itool=Abstract&log$=linkoutlink&nlmid=101549006" data-ga-category="link_out" data-ga-action="Molecular Biology Databases" data-ga-label="Gene Ontology" > Gene Ontology </a></li><li><a href="https://www.arabidopsis.org/publication?key=501742267" target="_blank" rel="noopener" ref="linksrc=linkout_link&PrId=3270&uid=21423366&db=pubmed&itool=Abstract&log$=linkoutlink&nlmid=101549006" data-ga-category="link_out" data-ga-action="Molecular Biology Databases" data-ga-label="The Arabidopsis Information Resource" > The Arabidopsis Information Resource </a></li></ul></li></ul> </div> </main> <div class="overlay" role="dialog" aria-label="Full Text Links Dialog"> <div id="full-text-links-dialog" class="dialog full-text-links-dialog"> <strong class="title">Full text links</strong> <button class="close-overlay" tabindex="3">[x]</button> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="https://doi.org/10.3389/fphys.2010.00024" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=6956&itool=Abstract-def&log$=linkouticon&uid=21423366&db=pubmed&nlmid=101549006" title="See full text options at Frontiers Media SA" tabindex="1" data-ga-category="full_text" data-ga-action="Frontiers Media SA" data-ga-label="21423366" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.frontiersin.org-alerts-logo-PubMed.png" alt="full text provider logo"><span class="text"> Frontiers Media SA </span></a><a class="link-item pmc " href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/21423366/" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=21423366&db=pubmed&nlmid=101549006" title="Free full text at PubMed Central" tabindex="2" data-ga-category="full_text" data-ga-action="PMC" data-ga-label="21423366" ><span class="text"> Free PMC article </span></a> </div> </div> </div> <div class="overlay" role="dialog" aria-label="Citation Dialog"> <div class="dialog citation-dialog"> <button class="close-overlay" tabindex="1">[x]</button> <div class="title">Cite</div> <div class="citation-text-block"> <div class="citation-text"></div> <div class="citation-actions"> <button class="copy-button dialog-focus" data-ga-category="save_share" data-ga-action="cite" data-ga-label="copy" tabindex="2"> Copy </button> <form method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="aK9U8rY2yaqlEdwPa3mWV2zHa3iiVef4NioDgbIpL7imAJNMV9mkmgllWVrS0HAw"> <button type="submit" class="export-button" data-ga-category="save_share" data-ga-action="cite" data-ga-label="download" title="Download a file for external citation management software" tabindex="3"> <span class="download-title">Download .nbib</span> <span class="download-title-mobile">.nbib</span> </button> </form> <div class="citation-style-selector-wrapper"> <label class="selector-label">Format:</label> <select aria-label="Format" class="citation-style-selector" tabindex="4"> <option data-style-url-name="ama" value="AMA" > AMA </option> <option data-style-url-name="apa" value="APA" > APA </option> <option data-style-url-name="mla" value="MLA" > MLA </option> <option data-style-url-name="nlm" value="NLM" selected="selected"> NLM </option> </select> </div> </div> </div> </div> </div> <div class="overlay" role="dialog" aria-label="More Actions Dialog"> <div id="more-actions-dialog" class="dialog more-actions-dialog"> <strong class="title">Send To</strong> <ul class="more-actions-links"> <li><a id="clipboard-trigger" role="button" class="submit-button clipboard-trigger clipboard-trigger-target dialog-focus link-item " href="#">Clipboard</a></li> <li><a class="email-trigger link-item" role="button" href="#">Email</a></li> <li><a class="save-trigger link-item" role="button" href="#">Save</a></li> <li><a class="link-item" role="button" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F21423366%2F%23open-bibliography-panel">My Bibliography</a></li> <li><a class="link-item" role="button" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F21423366%2F%23open-collections-panel">Collections</a></li> <li><a class="citation-manager-trigger link-item" role="button" href="#">Citation Manager</a></li> </ul> <button class="close-overlay">[x]</button> </div> </div> </div> <div id="ncbi-footer"> <div class="literature-footer" role="complementary" title="Links to NCBI Literature Resources"> <div class="usa-grid"> <p class="literature-footer-text">NCBI Literature Resources</p> <p class="literature-footer-text"> <a class="literature-footer-link" data-ga-category="literature_resources" data-ga-action="mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh/">MeSH</a> <a class="literature-footer-link" data-ga-category="literature_resources" data-ga-action="pmc_link" href="https://www.ncbi.nlm.nih.gov/pmc/">PMC</a> <a class="literature-footer-link" data-ga-category="literature_resources" data-ga-action="bookshelf_link" href="https://www.ncbi.nlm.nih.gov/books">Bookshelf</a> <a class="literature-footer-link" data-ga-category="literature_resources" data-ga-action="disclaimer_link" href="/disclaimer/">Disclaimer</a> </p> <p class="literature-footer-text attribution-statement">The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.</p> </div> </div>  <footer> <section class="icon-section"> <div id="icon-section-header" class="icon-section_header">Follow NCBI</div> <div class="grid-container container"> <div class="icon-section_container"> <a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter"> <svg width="40" height="40" viewBox="0 0 40 37" fill="none" xmlns="http://www.w3.org/2000/svg"> <title>Twitter</title> <g id="twitterx1008"> <path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"/> </g> </svg> </a> <a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 300 300"> <title>Facebook</title> <path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z"> </path> </svg></a> <a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 300 300"> <title>LinkedIn</title> <path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z"> </path> </svg></a> <a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 300 300"> <defs> <style> .cls-11, .cls-12 { fill: #737373; } .cls-11 { fill-rule: evenodd; } </style> </defs> <title>GitHub</title> <path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z"> </path> <path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1"> </path> <path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08"> </path> <path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path> <path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0"> </path> <path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0"> </path> <path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0"> </path> <path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path> </svg></a> <a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 40"><defs><style>.cls-1{fill:#737373;}</style></defs><path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"/></svg> </a> </div> </div> </section> <section class="container-fluid bg-primary"> <div class="container pt-5"> <div class="row mt-3"> <div class="col-lg-3 col-12"> <p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p> <ul class="list-inline social_media"> <li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer"> <svg width="35" height="35" viewBox="0 0 38 35" fill="none" xmlns="http://www.w3.org/2000/svg"> <title>Twitter</title> <g id="twitterx1009" clip-path="url(#clip0_65276_3946)"> <path id="Vector" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.2" stroke-miterlimit="10"></path> <path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path> </g> <defs> <clipPath id="clip0_65276_3946"> <rect width="38" height="38" fill="white"></rect> </clipPath> </defs> </svg></a> </li> <li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank"> <svg version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve"> <style type="text/css"> .st10 { fill: #FFFFFF; } .st110 { fill: none; stroke: #FFFFFF; stroke-width: 8; stroke-miterlimit: 10; } </style> <title>SM-Facebook</title> <g> <g> <path class="st10" d="M159,99.1h-24V88.4c0-5,3.3-6.2,5.7-6.2h16.8V60l-24.4-0.1c-22.1,0-26.2,16.5-26.2,27.1v12.1H90v22.5h16.9 v67.5H135v-67.5h21.7L159,99.1z"></path> </g> </g> <circle class="st110" cx="123.6" cy="123.2" r="108.2"></circle> </svg> </a></li> <li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve"> <title>SM-Youtube</title> <style type="text/css"> .st4 { fill: none; stroke: #FFFFFF; stroke-width: 8; stroke-miterlimit: 10; } .st5 { fill: #FFFFFF; } </style> <circle class="st4" cx="124.2" cy="123.4" r="108.2"></circle> <g transform="translate(0,-952.36218)"> <path class="st5" d="M88.4,1037.4c-10.4,0-18.7,8.3-18.7,18.7v40.1c0,10.4,8.3,18.7,18.7,18.7h72.1c10.4,0,18.7-8.3,18.7-18.7 v-40.1c0-10.4-8.3-18.7-18.7-18.7H88.4z M115.2,1058.8l29.4,17.4l-29.4,17.4V1058.8z"></path> </g> </svg></a></li> </ul> </div> <div class="col-lg-3 col-12"> <p class="address_footer text-white">National Library of Medicine<br> <a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br> Bethesda, MD 20894</a></p> </div> <div class="col-lg-3 col-12 centered-lg"> <p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br> <a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br> <a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p> </div> <div class="col-lg-3 col-12 centered-lg"> <p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br> <a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br> <a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p> </div> </div> <div class="row"> <div class="col-lg-12 centered-lg"> <nav class="bottom-links"> <ul class="mt-3"> <li> <a class="text-white" href="//www.nlm.nih.gov/">NLM</a> </li> <li> <a class="text-white" href="https://www.nih.gov/">NIH</a> </li> <li> <a class="text-white" href="https://www.hhs.gov/">HHS</a> </li> <li> <a class="text-white" href="https://www.usa.gov/">USA.gov</a> </li> </ul> </nav> </div> </div> </div> </section> </footer>   <script type="text/javascript"> var nwds_version = "1.2.3"; var meta_nwds_ver = document.createElement('meta'); meta_nwds_ver.name = 'ncbi_nwds_ver'; meta_nwds_ver.content = nwds_version; document.getElementsByTagName('head')[0].appendChild(meta_nwds_ver); var meta_nwds = document.createElement('meta'); meta_nwds.name = 'ncbi_nwds'; meta_nwds.content = 'yes'; document.getElementsByTagName('head')[0].appendChild(meta_nwds); var alertsUrl = "/core/alerts/alerts.js"; if (typeof ncbiBaseUrl !== 'undefined') { alertsUrl = ncbiBaseUrl + alertsUrl; } </script> </div>  <script src="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/js/output.293fbf76aa18.js"></script>  <script src="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/js/output.550e9c8906a2.js"></script> <script> ncbi.awesome.basePage.init({ userInfo: { isLoggedIn: false, username: "", loginUrl: "https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F21423366%2F", logoutUrl: "https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/21423366/" }, baseUrl: 'https://www.ncbi.nlm.nih.gov', noSessionCookieName: "pm-ns", searchIdCookieName: "pm-sid", adjNavSearchIdCookieName: "pm-adjnav-sid", searchFormSubmittedCookieName: "pm-sfs", isOnSearchPageCookieName: "pm-iosp", backToSearchCookieName: "pm-btsl", clinicalSeeAllCookieName: "pm-csa", jsCookieDomain: "pubmed.ncbi.nlm.nih.gov", userShareRequestFailed: "", noSharedSettings: "myncbi_no_shared_settings", noSharedAccount: "myncbi_no_shared_account" }); </script> <script type="module"> import dismissableNCBIAlert from "https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/core/dismissable-ncbi-alert.js"; jQuery.getScript("https://www.ncbi.nlm.nih.gov/core/alerts/alerts.js", function () { galert(['body > *:last-child']); dismissableNCBIAlert(); }).fail(function() { }); </script> <script defer type="text/javascript" src="https://cdn.ncbi.nlm.nih.gov/core/pinger/pinger.js"> </script> <script src="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/js/output.04d45d85d031.js"></script> <script> ncbi.awesome.articlePage.init({ baseSuggestionsUrl: "/suggestions/", mathJaxUrl: "https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/mathjax/unpacked/MathJax.js?config=MML_CHTML", clipboardAPIRoot: "/ajax/clipboard/", clipboardNextPageUrl: "/clipboard-next-page/", searchIdCookieName: "pm-sid", searchFormSubmittedCookieName: "pm-sfs", backToSearchCookieName: "pm-btsl", jsCookieDomain: "pubmed.ncbi.nlm.nih.gov", longTermPrefix: "longquery", adjNavURLPath: "/21423366/adj-nav/", adjNavSearchIdCookieName: "pm-adjnav-sid", articlePageUrl: "/21423366/", markJSUrl: "https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/mark.js/dist/jquery.mark.js", termHighlightColor: "", highlightedTokens: "", citeFormatPreferenceCookieName: "pm-cf" }); </script> </body> </html>

CINXE.COM

A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2 - PubMed