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Strategic Directions 2020-2025 | National Institute on Aging
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layout-content main-article clearfix" role="content"> <div id="block-nia-local-tasks" class="block_local_tasks"> </div> <div class="content content-inner col-12-full"> <aside class="sidebar column_left col-3-left"> <div class="sidenav-wrapper"> <nav aria-label="Side navigation"> <ul class="usa-sidenav usa-accordion flex-justify"> <li class="usa-nav__primary-item usa-sidenav__primary-item sidenav--last-link"> <a href="/about/aging-strategic-directions-research" class="usa-nav__link usa-current" class="usa-nav__link usa-current"> <span>The National Institute on Aging: Strategic Directions for Research, 2020-2025</span> </a> </li> </ul> <div id="block-booknavigation" class="block block-book block-book-navigation"> <nav aria-label="Side navigation"> <ul class="usa-sidenav usa-accordion flex-justify"> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/understanding-dynamics-aging" class="usa-nav__link" class="usa-nav__link"> <span>Understanding the Dynamics of the Aging Process</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-biology-impact" class="usa-nav__link" class="usa-nav__link"> <span>Goal A: Better understand the biology of aging and its impact on the prevention, progression, and prognosis of disease and disability</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-behavioral-psychological-factors" class="usa-nav__link" class="usa-nav__link"> <span>Goal B: Better understand the effects of personal, interpersonal, and societal factors on aging, including the mechanisms through which these factors exert their effects </span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/improving-health-well-being" class="usa-nav__link" class="usa-nav__link"> <span>Improving the Health, Well-Being, and Independence of Adults as They Age </span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-health-interventions" class="usa-nav__link" class="usa-nav__link"> <span>Goal C: Develop effective interventions to maintain health, well-being, and function and prevent or reduce the burden of age-related diseases, disorders, and disabilities</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-brain-alzheimers-neurological" class="usa-nav__link" class="usa-nav__link"> <span>Goal D: Improve our understanding of the aging brain, Alzheimer’s disease, related dementias, and other neurodegenerative diseases. Develop interventions to address Alzheimer’s and other age-related neurological conditions</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-society-policy" class="usa-nav__link" class="usa-nav__link"> <span>Goal E: Improve our understanding of the consequences of an aging society to inform intervention development and policy decisions</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-health-disparities-adults" class="usa-nav__link" class="usa-nav__link"> <span>Goal F: Understand health disparities related to aging and develop strategies to improve the health status of older adults in diverse populations</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-support-infrastructure-research" class="usa-nav__link" class="usa-nav__link"> <span>Goal G: Support the infrastructure and resources needed to promote high-quality research</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-information-scientific-medical" class="usa-nav__link" class="usa-nav__link"> <span>Goal H: Disseminate information to the public; scientific and medical communities; stakeholder advocacy, community and older adult-support organizations; the media; and policymakers about research and interventions</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item"> <a href="/about/aging-strategic-directions-research/goal-steward-public-resources" class="usa-nav__link" class="usa-nav__link"> <span>Goal I: Effectively steward public resources</span> </a> </li> <li class="usa-nav__primary-item usa-sidenav__primary-item sidenav--last-link"> <a href="/about/aging-strategic-directions-research/appendices" class="usa-nav__link" class="usa-nav__link"> <span>Strategic Directions Appendices </span> </a> </li> </ul> </div> </div> </aside> <article class="content_main col_right col-9-right"> <div class="content_inset clearfix"> <h1 class="page-title node-title"> The National Institute on Aging: Strategic Directions for Research, 2020-2025 </h1> <h2>From the Director</h2><aside class="custom-callout__inline custom-callout__blue width-50ct float-right"><h3>We want to hear from you</h3><p>To help shape the future of aging research in the United States, NIA is developing the Strategic Directions for Research for 2026-2030. <a href="/about/provide-input-nias-strategic-directions-research-2026-2030">Learn more and share your thoughts.</a></p></aside><p>I am pleased to present the strategic directions of the National Institute on Aging (NIA) for 2020-2025. Today, there are more Americans ages 65 and older — just over 49 million, according to the U.S. Census — than at any other time in history, and we expect these numbers to grow as more Baby Boomers (individuals born between 1946 and 1964) reach retirement age. We can attribute this unprecedented demographic shift to a variety of factors, many of which benefit people of all ages. For example, even within the lifetimes of today’s older Americans, infectious diseases that once cut millions of lives short have been largely controlled in the U.S., and public health campaigns and policy changes — for example, smoking cessation efforts and laws mandating seat belt use — have saved many more lives.</p><p>Despite these advances, aging itself remains the most significant risk factor for many chronic diseases and conditions, including Alzheimer’s disease and related forms of dementia (AD/ADRD), most types of cancer, many types of heart disease, osteoporosis and hip fracture, kidney failure, and diabetes. While these diseases are rarely inevitable, it is probable that as the number of older Americans increases, so too will the number of people with age-related diseases. A significant increase in the number of individuals with serious chronic conditions will have profound social and economic effects on the nation.</p><p>NIA is meeting these challenges through its ongoing mission to:</p><ul><li>Support and conduct genetic, biological, clinical, behavioral, social, and economic research on aging.</li><li>Foster the development of research and clinician scientists in aging.</li><li>Provide research resources.</li><li>Disseminate information about aging and advances in research to the public, health care professionals, and the scientific community, among a variety of audiences.</li></ul><p>Our primary activities include funding extramural research at universities and research centers across the U.S. and around the world; maintaining an active communications and outreach program; and conducting a vibrant intramural research program at NIA laboratories in Baltimore and Bethesda, Maryland. In addition, as the lead federal agency for research on AD/ADRD, NIA has received an unprecedented influx of funding targeted toward understanding and addressing these conditions over the past seven years, and our plans and priorities reflect this extraordinary opportunity for discovery.</p><p>This document presents our scientific priorities for the next five years. Consistent with guidance in the 21st Century Cures Act, we also lay out our goals and objectives with respect to some of the “behind the scenes” activities we conduct in order to support the science. It is our hope that this description of our priorities is useful to you, whether you’re an independent researcher, an advocate, or an interested layperson.</p><p>For up-to-date information about NIA’s activities, priorities, and advances, I invite you to visit our web site at <a href="/">www.nia.nih.gov</a>.</p><p>Sincerely,</p><p>Richard J. Hodes, M.D.</p><h2>The National Institute on Aging</h2><p>The National Institute on Aging (NIA) is one of 27 Institutes and Centers of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services. Our mission encompasses basic, translational, and clinical research; training and career support for investigators at all levels; resource allocation; and health communication to a range of audiences. Congress established the NIA in 1974 to lead a national scientific effort to understand the nature of aging in order to promote the health and well-being of older adults. The Institute was subsequently designated as the lead within NIH for research on Alzheimer’s disease and related forms of dementia (AD/ADRD).<br>NIA pursues its mission by funding extramural research at universities and medical centers across the U.S. and around the world; maintaining an active communications and outreach program; and conducting a vibrant intramural research program at NIA laboratories in Baltimore and Bethesda, Maryland.</p><p>Public Law 93-296 authorizes the establishment of a National Institute on Aging and requires that the institute develop a national comprehensive plan to coordinate the Health, Education, Welfare (HEW) agencies involved in aging research. The Institute’s purpose, functions, and certain activities are described in 42 U.S. Code §285e.</p><h2>About This Document</h2><figure role="group" class="image-none img_inline align-right"> <img alt="The National Institute on Aging: Strategic Directions for Research, 2020-2025" data-entity-type="file" data-entity-uuid="6ce3b3c8-7072-4731-bc82-2682067e3ba3" data-image-style="inline_right" data-insert-class="image-none img_inline" data-insert-type="image" loading="lazy" src="/sites/default/files/inline-images/strategic-directions-research-cover.jpg" typeof="foaf:Image" width="230" height="298"> <figcaption><a href="/sites/default/files/2020-05/nia-strategic-directions-2020-2025.pdf">Download a PDF</a> of The National Institute on Aging: Strategic Directions for Research, 2020-2025. (PDF, 3.03M)</figcaption> </figure> <p>This document outlines NIA’s broad strategic directions. It provides a point of reference for setting priorities and a framework for systematically analyzing the Institute’s scientific portfolio and assessing progress. NIA developed and refined these goals over a one-year period, receiving valuable input and feedback from stakeholders in the research community, nongovernmental organizations, partners within NIH and elsewhere within the federal government, and members of the general public via a November 2018 <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-AG-18-034.html">Request for Information</a>. We will update the document as needed as the field of aging research evolves.</p><p>Our goals are as follows:</p><h3>Understanding the Dynamics of the Aging Process</h3><ul><li><a href="/about/aging-strategic-directions-research/goal-biology-impact"><strong>Goal A:</strong> Better understand the biology of aging and its impact on the prevention, progression, and prognosis of disease and disability.</a></li><li><a href="/about/aging-strategic-directions-research/goal-behavioral-psychological-factors"><strong>Goal B:</strong> Better understand the effects of personal, interpersonal, and societal factors on aging, including the mechanisms through which these factors exert their effects.</a></li></ul><h3>Improving the Health, Well-Being, and Independence of Adults as They Age</h3><ul><li><a href="/about/aging-strategic-directions-research/goal-health-interventions"><strong>Goal C:</strong> Develop effective interventions to maintain health, well-being, and function and prevent or reduce the burden of age-related diseases, disorders, and disabilities.</a></li><li><a href="/about/aging-strategic-directions-research/goal-brain-alzheimers-neurological"><strong>Goal D:</strong> Improve our understanding of the aging brain, Alzheimer’s disease, related dementias, and other neurodegenerative diseases. Develop interventions to address Alzheimer’s and other age-related neurological conditions.</a></li><li><a href="/about/aging-strategic-directions-research/goal-society-policy"><strong>Goal E:</strong> Improve our understanding of the consequences of an aging society to inform intervention development and policy decisions.</a></li><li><a href="/about/aging-strategic-directions-research/goal-health-disparities-adults"><strong>Goal F:</strong> Understand health disparities related to aging and develop strategies to improve the health status of older adults in diverse populations.</a></li></ul><h3>Supporting the Research Enterprise</h3><ul><li><a href="/about/aging-strategic-directions-research/goal-support-infrastructure-research"><strong>Goal G:</strong> Support the infrastructure and resources needed to promote high-quality research.</a></li><li><a href="/about/aging-strategic-directions-research/goal-information-scientific-medical"><strong>Goal H:</strong> Disseminate information to the public; scientific and medical communities; stakeholder advocacy, community and older adult-support organizations; the media; and policymakers about research and interventions.</a></li><li><a href="/about/aging-strategic-directions-research/goal-steward-public-resources"><strong>Goal I:</strong> Effectively steward public resources.</a></li></ul><p><em><strong>Our vision is to enable all Americans to enjoy robust health and independence with advancing age.</strong></em></p><aside class="custom-callout__inline custom-callout__blue width-full"><h3>How will we measure progress?</h3><p>As a component of the NIH, NIA supports research with the goal of curing disease and improving overall health. However, the path from bench to bedside — that is, from basic scientific discovery to clinical application — is often long and is rarely straightforward. It’s the nature of biomedical science that years or even decades worth of incremental advances may be necessary before a basic discovery, however ground-breaking, pays off in the form of new interventions to benefit health. While a direct link can sometimes be drawn between specific funding and an improvement in health, more often the story is complex. Furthermore, with each new breakthrough, science can advance and evolve in unanticipated ways. These new directions also serve as indicators of progress, and we consider them to be a successful outcome of our support, even when direct clinical application is not immediately evident.</p><p>With all of this in mind, NIA will use both quantitative and qualitative techniques to measure progress toward the priorities described in this document; analyze the scientific, clinical, and public health impact of its research; and periodically report results to stakeholders. We will do this through regular analysis and evaluation of programs and initiatives that have been developed in support of our priorities. Because no two programs or initiatives are exactly the same, the tools, measures, and approaches we use for each evaluation or analysis will differ. However, we anticipate working with partners across NIH, such as the Office of Portfolio Analysis and the Office of Program Evaluation, Performance, and Reporting to track progress and initiate course corrections where necessary.</p></aside> <nav class="book-nav--wrapper" role="navigation" aria-labelledby="book-label-31512"> <ul class="book-nav"> <li class="chapter book-nav--item"> <a href="/about/aging-strategic-directions-research/understanding-dynamics-aging" rel="next" title="Go to next page" class="chapter-link next"><span class="chapter-title">Understanding the Dynamics of the Aging Process</span></a> </li> </ul> </nav> </div> <p><strong>Last updated:</strong> October 22, 2024</p> </article> </div> </article> </main> </div> <footer class="usa-footer usa-footer--medium font-body-sm" role="contentinfo"> <div class="grid-container usa-footer__return-to-top"> <a href="#">Return to top</a> </div> <div class="usa-footer__primary-section"> <div class="grid-container"> <div 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