The Contribution of the Neural Crest to the Vertebrate Body

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Le Douarin","affiliation":[{"name":"CNRS UMR 7128","address":{"name":"Laboratoire d’Embryologie Cellulaire et Moléculaire, CNRS UMR 7128, Nogent-sur-Marne Cedex, France","@type":"PostalAddress"},"@type":"Organization"}],"email":"nicole.le-douarin@college-de-france.fr","@type":"Person"}],"keywords":"Neural Crest, Neural Crest Cell, Facial Skeleton, Neural Crest Stem Cell, Cranial Neural Crest Cell","description":"As a transitory structure providing adult tissues of the vertebrates with very diverse cell types, the neural crest (NC) has attracted for long the interest of developmental biologists and is still the subject of ongoing research in a variety of animal models. Here we review a number of data from in vivo cell tracing and in vitro single cell culture experiments, which gained new insights on the mechanisms of cell migration, proliferation and differentiation during NC ontogeny. 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2x" alt=""> </picture> <span class="app-article-masthead__journal-title ">Neural Crest Induction and Differentiation</span> </a> <span class="app-article-masthead__conference-info"></span> </div> </div> </div> </section> </div> <div class="c-article-main u-container u-mt-24 u-mb-32 l-with-sidebar" id="main-content" data-component="article-container"> <main class="js-main-column u-serif c-chapter-body" data-track-component="chapter"> <article lang="en"> <div class="c-article-header"> <header> <div class="app-overview-section"> <ul class="c-article-author-list c-article-author-list--short" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Elisabeth-Dupin" data-author-popup="auth-Elisabeth-Dupin">Elisabeth Dupin</a><sup class="u-js-hide"><a href="#Aff7">7</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Sophie-Creuzet" data-author-popup="auth-Sophie-Creuzet">Sophie Creuzet</a><sup class="u-js-hide"><a href="#Aff7">7</a></sup> & </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Nicole_M_-Douarin" data-author-popup="auth-Nicole_M_-Douarin" data-corresp-id="c1">Nicole M. Le Douarin<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff7">7</a></sup> </li></ul> <div class="app-overview-section__separator app-overview-section__book-series"> <div class="app-book-series-listing"> <div> <svg class="app-book-series-listing__icon" width="24" height="24" aria-hidden="true" focusable="false"><use href="#icon-eds-i-book-series-medium"></use></svg> </div> <div> <p data-test="series-link"> <span class="app-book-series-listing__description">Part of the book series:</span> <a href="https://www.springer.com/series/5584" data-track="click" data-track-action="open book series" data-track-label="link">Advances in Experimental Medicine and Biology</a> ((volume 589)) </p> </div> </div> </div> <div class="app-overview-section__separator" data-test="article-metrics"> <div id="altmetric-container"> <ul class="app-article-metrics-bar u-list-reset" data-test="article-metrics"> <li class="app-article-metrics-bar__item" data-test="access-count"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-accesses-medium"></use> </svg>2371 <span class="app-article-metrics-bar__label">Accesses</span></p> </li> <li class="app-article-metrics-bar__item" data-test="altmetric-score"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-altmetric-medium"></use> </svg>9 <span class="app-article-metrics-bar__label"> <a href="https://link.altmetric.com/details/4089093" target="_blank" rel="noopener" title="Visit Altmetric for full social mention details" data-track="click" data-track-action="Social mentions" data-track-label="link">Altmetric</a> </span></p> </li> </ul> </div> </div> </div> </header> </div> <div data-article-body="true" data-track-component="chapter body" class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 id="Abs1" class="c-article-section__title js-section-title js-c-reading-companion-sections-item">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><p>As a transitory structure providing adult tissues of the vertebrates with very diverse cell types, the neural crest (NC) has attracted for long the interest of developmental biologists and is still the subject of ongoing research in a variety of animal models. Here we review a number of data from in vivo cell tracing and in vitro single cell culture experiments, which gained new insights on the mechanisms of cell migration, proliferation and differentiation during NC ontogeny. We put emphasis on the role of <i>Hox</i> genes, morphogens and interactions with neighbouring tissues in specifying and patterning the skeletogenic NC cells in the head. 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The Contribution of the Neural Crest to the Vertebrate Body | SpringerLink