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class="entry-header"> <div class="entry-header-content"> <div class="entry-title-contain"> <h1 class="entry-title">Target Classes</h1> </div> </div> </header> </div> <div id="content-contain"> <div id="primary" class="content-area"> <main id="main" class="site-main" role="main"> <article id="post-23263" class="post-23263 page type-page status-publish hentry"> <div class="entry-content"> <div class="blocks-content"> <div class="kb-row-layout-wrap kb-row-layout-id_ad1d9b-8f alignwide wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column_2cbb01-cf inner-column-1"><div class="kt-inside-inner-col"><div class="kb-row-layout-wrap kb-row-layout-id_5cccc2-fd alignnone wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column_5ada4d-45 inner-column-1"><div class="kt-inside-inner-col"> <h2 class="wp-block-heading has-text-align-right">Diverse Discovery at an <em>Exponential Pace</em></h2> </div></div> </div></div></div></div> <div class="wp-block-kadence-column kadence-column_3691b7-63 inner-column-2"><div class="kt-inside-inner-col"> <p>X-Chem’s DNA-encoded library (DEL) technology and medicinal chemistry expertise take small molecule discovery to another level. Along with the ability to screen <strong>billions of compounds</strong> rapidly, our proprietary methods enable you to screen against difficult and previously “undruggable” targets.  </p> </div></div> </div></div>  <div id="separator-block_d8b2c60d5d5b646177c122247ea6376d" class="block-separator alignwide"> <svg id="Layer_1" data-name="Layer 1" class="x-separator" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1897.14 16.62" preserveAspectRatio="xMidYMid slice"><defs><style>.cls-1{fill:#9aca3c;}.cls-2{fill:#2aa1db;}.cls-3{fill:#ef4379;}.cls-4{fill:#e6e6e6;stroke:#e6e6e6;stroke-miterlimit:10;}</style></defs><path class="cls-1" d="M932,16.34h-8.92a1.29,1.29,0,0,1-1.24-.9L919.07,7a1.31,1.31,0,0,1,.48-1.46L926.76.26a1.29,1.29,0,0,1,1.54,0l7.21,5.2A1.31,1.31,0,0,1,936,6.92l-2.76,8.54A1.29,1.29,0,0,1,932,16.34Zm-8-2.62h7l2.16-6.66-5.67-4.13-5.67,4.13Z" transform="translate(0 0)"/><path class="cls-2" d="M953.16,15.23h-11.5a1.31,1.31,0,0,1-1.27-1.31V2.46a1.31,1.31,0,0,1,1.31-1.31h11.5a1.31,1.31,0,0,1,1.27,1.31V13.92A1.31,1.31,0,0,1,953.16,15.23ZM943,12.61h8.88V3.74H943Z" transform="translate(0 0)"/><path class="cls-3" d="M971,16.62h-7.44a1.29,1.29,0,0,1-1.13-.66l-3.72-6.44a1.33,1.33,0,0,1,0-1.31l3.72-6.44a1.3,1.3,0,0,1,1.13-.65H971a1.33,1.33,0,0,1,1.14.65l3.71,6.44a1.28,1.28,0,0,1,0,1.31L972.15,16A1.32,1.32,0,0,1,971,16.62ZM964.33,14h5.93l3-5.13-3-5.13h-5.93l-3,5.13Z" transform="translate(0 0)"/><rect class="cls-4" x="0.5" y="8.38" width="863" height="2"/><rect class="cls-4" x="1033.64" y="8.37" width="863" height="2"/></svg> </div> <p class="has-text-align-center">Our highly optimized small molecule screening approach has successfully delivered hit compounds against a host of target class applications: </p> <div class="kb-row-layout-wrap kb-row-layout-id_479972-b6 alignnone wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column_420a84-47"><div class="kt-inside-inner-col"> <ul class="wp-block-list"> <li><a href="#protein-protein-interactions">Protein-Protein Interactions (PPIs)</a> </li> <li><a href="#targeted-protein-degradation-and-glues">Targeted Protein Degradation (TPD) and Glues </a></li> <li><a href="#covalent-inhibitors">Covalent Inhibitors</a></li> </ul> </div></div> <div class="wp-block-kadence-column kadence-column_c0714e-ce"><div class="kt-inside-inner-col"> <ul class="wp-block-list"> <li><a href="#antivirals">Antivirals</a></li> <li><a href="#kinases">Kinases</a></li> <li><a href="#gpcrs">G protein-coupled receptors (GPCRs)</a> </li> </ul> </div></div> </div></div> <p>Recent advances in these difficult classes point to previously unattainable possibilities for drug development. From PPI research to bispecific molecules. From covalents to novel GPCR antagonists, the future is bright. Whatever your modality, X-Chem can help put your novel therapy on the path to clinic. </p> <div class="kb-row-layout-wrap kb-row-layout-id_606682-d9 alignnone wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column_62121b-58" id="protein-protein-interactions"><div class="kt-inside-inner-col"> <div class="wp-block-kadence-infobox kt-info-box_82a449-96 target-class"><a class="kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-left" href="https://www.x-chemrx.com/protein-protein-interactions/"><div class="kt-infobox-textcontent"><h3 class="kt-blocks-info-box-title">Protein-Protein Interactions</h3><p class="kt-blocks-info-box-text">Protein-protein interactions are a traditionally challenging but emerging target class for therapeutic drug design. Their large, flat surfaces present difficulties for small molecule screening, but X-Chem’s powerful DEL technology leverages <strong>billions of compounds</strong> to make expedited PPI discovery an area of strength. </p><div class="kt-blocks-info-box-learnmore-wrap"><span class="kt-blocks-info-box-learnmore">Learn More</span></div></div></a></div> </div></div> <div class="wp-block-kadence-column kadence-column_0dba96-90" id="targeted-protein-degradation-and-glues"><div class="kt-inside-inner-col"> <div class="wp-block-kadence-infobox kt-info-box_279481-6f target-class"><a class="kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-left" href="https://www.x-chemrx.com/targeted-protein-degradation-molecular-glues/"><div class="kt-infobox-textcontent"><h3 class="kt-blocks-info-box-title"><strong>Targeted Protein Degradation and Glues</strong></h3><p class="kt-blocks-info-box-text">TPD requires linkage of molecule fragments; DEL technology provides that linker. TPD is opening new doors in drug development, and X-Chem’s DEL is the perfect tool for any modality in this space. Molecular glues induce protein association without the need for chimeric molecules. Only the very largest libraries and efficient selection methods can uncover such rare and valuable compounds. </p><div class="kt-blocks-info-box-learnmore-wrap"><span class="kt-blocks-info-box-learnmore">Learn More</span></div></div></a></div> </div></div> </div></div> <div class="kb-row-layout-wrap kb-row-layout-id_8ef4a6-ae alignnone wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column_775119-f9" id="covalent-inhibitors"><div class="kt-inside-inner-col"> <div class="wp-block-kadence-infobox kt-info-box_ee4f58-aa target-class"><a class="kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-left" href="https://www.x-chemrx.com/covalent-inhibitors/"><div class="kt-infobox-textcontent"><h3 class="kt-blocks-info-box-title">Covalent Inhibitors</h3><p class="kt-blocks-info-box-text">Innovation is built into every solution at X-Chem, and our scientists have demonstrated this foundational tenet through the powerful pairing of our platform and covalent inhibitor libraries. We invented covalent DEL, and our DELvalent service puts the world’s leading covalent screening method and all the possibilities of this modality within your grasp. </p><div class="kt-blocks-info-box-learnmore-wrap"><span class="kt-blocks-info-box-learnmore">Learn More</span></div></div></a></div> </div></div> <div class="wp-block-kadence-column kadence-column_87c30b-a3" id="kinases"><div class="kt-inside-inner-col"> <div class="wp-block-kadence-infobox kt-info-box_bcc09e-77 target-class"><a class="kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-left" href="https://www.x-chemrx.com/kinases/"><div class="kt-infobox-textcontent"><h3 class="kt-blocks-info-box-title">Kinases</h3><p class="kt-blocks-info-box-text">Kinases are a well-explored target class and the bread and butter of many drug discovery programs. Yet, unexplored territory remains … this is where X-Chem shines. With the structural novelty of our vast library and tunable selection methods, we can discover selective, pan-, and allosteric inhibitors for your kinase of interest. </p><div class="kt-blocks-info-box-learnmore-wrap"><span class="kt-blocks-info-box-learnmore">Learn More</span></div></div></a></div> </div></div> </div></div> <div class="kb-row-layout-wrap kb-row-layout-id_04b74a-fc alignnone wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column_e58d29-ba" id="antivirals"><div class="kt-inside-inner-col"> <div class="wp-block-kadence-infobox kt-info-box_d9e591-e0 target-class"><div class="kt-blocks-info-box-link-wrap kt-blocks-info-box-media-align-top kt-info-halign-left"><div class="kt-infobox-textcontent"><h3 class="kt-blocks-info-box-title">Antivirals</h3><p class="kt-blocks-info-box-text">The potential applications of our DEL screening technology in the drug discovery process are virtually limitless, as we are discovering in the realm of antivirals. We’re applying our industry-leading DEL and medicinal chemistry expertise in a <a href="https://www.x-chemrx.com/about/news/arbutus-biopharma-x-chem-and-proteros-biostructures-achieve-first-milestone-under-covid-19-discovery-research-and-license-agreement/" target="_blank" rel="noreferrer noopener">collaborative effort</a> to target the SARS-CoV-2 nsp5 main protease (M<sup>pro</sup>). </p></div></div></div> </div></div> <div class="wp-block-kadence-column kadence-column_2a7a98-83" id="gpcrs"><div class="kt-inside-inner-col"> <div class="wp-block-kadence-infobox kt-info-box_f4e2e0-73 target-class"><a class="kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-top kt-info-halign-left" href="https://www.x-chemrx.com/gpcr-discovery/"><div class="kt-infobox-textcontent"><h3 class="kt-blocks-info-box-title">GPCRs</h3><p class="kt-blocks-info-box-text">GPCRs are a well-validated target class but can be difficult for biophysical screening methods. Using our DEL technology and massive libraries, we have identified potent hits that bind GPCRs. With <strong>billions of compounds </strong>available to screen, X-Chem can power the success of your GPCR discovery campaign. </p><div class="kt-blocks-info-box-learnmore-wrap"><span class="kt-blocks-info-box-learnmore">Learn More</span></div></div></a></div> </div></div> </div></div>  <div id="separator-block_d8b2c60d5d5b646177c122247ea6376d" class="block-separator alignwide"> <svg id="Layer_1" data-name="Layer 1" class="x-separator" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1897.14 16.62" preserveAspectRatio="xMidYMid slice"><defs><style>.cls-1{fill:#9aca3c;}.cls-2{fill:#2aa1db;}.cls-3{fill:#ef4379;}.cls-4{fill:#e6e6e6;stroke:#e6e6e6;stroke-miterlimit:10;}</style></defs><path class="cls-1" d="M932,16.34h-8.92a1.29,1.29,0,0,1-1.24-.9L919.07,7a1.31,1.31,0,0,1,.48-1.46L926.76.26a1.29,1.29,0,0,1,1.54,0l7.21,5.2A1.31,1.31,0,0,1,936,6.92l-2.76,8.54A1.29,1.29,0,0,1,932,16.34Zm-8-2.62h7l2.16-6.66-5.67-4.13-5.67,4.13Z" transform="translate(0 0)"/><path class="cls-2" d="M953.16,15.23h-11.5a1.31,1.31,0,0,1-1.27-1.31V2.46a1.31,1.31,0,0,1,1.31-1.31h11.5a1.31,1.31,0,0,1,1.27,1.31V13.92A1.31,1.31,0,0,1,953.16,15.23ZM943,12.61h8.88V3.74H943Z" transform="translate(0 0)"/><path class="cls-3" d="M971,16.62h-7.44a1.29,1.29,0,0,1-1.13-.66l-3.72-6.44a1.33,1.33,0,0,1,0-1.31l3.72-6.44a1.3,1.3,0,0,1,1.13-.65H971a1.33,1.33,0,0,1,1.14.65l3.71,6.44a1.28,1.28,0,0,1,0,1.31L972.15,16A1.32,1.32,0,0,1,971,16.62ZM964.33,14h5.93l3-5.13-3-5.13h-5.93l-3,5.13Z" transform="translate(0 0)"/><rect class="cls-4" x="0.5" y="8.38" width="863" height="2"/><rect class="cls-4" x="1033.64" y="8.37" width="863" height="2"/></svg> </div> <div class="wp-block-group no-bottom"><div class="wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained"> <h2 class="wp-block-heading has-text-align-center">Proven Capabilities Applied to Your Project</h2> <p><a href="https://www.x-chemrx.com/del-track-record/" target="_blank" rel="noreferrer noopener">X-Chem’s track record</a> of leading DNA-encoded library-based discovery for over a decade is well-documented. We have delivered validated hits in 30+ target classes across numerous therapeutic areas, and we’re just getting started. Pioneer the future of drug discovery with the experts<br>at X-Chem. </p> </div></div> </div> </div> </article> </main> </div> </div>  </div> <div data-wpr-lazyrender="1" id="pre-foot"> <div class="pre-foot-content"> <h3 id="foot-cta">Small Molecules Hold Exponential Possibilities <br><strong>Find Your Next Drug Candidate With X-Chem </strong></h3> <a id="foot-cta-link" href="https://www.x-chemrx.com/contact-us/" target="" class="btn reverse">Talk to Us</a> </div> </div> <footer data-wpr-lazyrender="1" id="colophon" class="site-footer"> <div class="foot-content row"> <div id="site-info" class="site-info foot-part"> <div class="site-info-row"> <p id="copyright-statement">© 2024 X-Chem. 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