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Clinical Trials | Coma Neuroscience Lab

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class="tabs"></div> <div class="region region-content"> <div id="block-system-main" class="block block-system"> <div class="content"> <div id="node-301" class="node node-page slider-secondary clearfix" about="/clinical-trials-0" typeof="sioc:Item foaf:Document"> <span property="dc:title" content="Clinical Trials" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-body field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>聽</p> <p>聽</p> <h1>Clinical Trials</h1> <p><img alt="" height="63" src="/sites/g/files/tkssra6046/f/wysiwyg/restore_high_res_white.png" style="float:left" width="300" /></p> <p>聽</p> <p>聽</p> <p>聽</p> <p><a href="https://classic.clinicaltrials.gov/ct2/show/NCT05851391">buRst-supprESsion TO stop Refractory status Epilepticus post-cardiac arrest</a>聽(NCT05851391)</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Contact: Edilberto Amorim, MD (PI)聽<a href="/cdn-cgi/l/email-protection#cfaea2a0bda6a28fbaacbca9e1aaabba" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="67060a08150e0a271204140149020312">[email&#160;protected]</span></a>聽聽聽Kevin Bao (CRC) <a href="/cdn-cgi/l/email-protection#9ff4fae9f6f1b1fdfef0dfeafcecf9b1fafbea"><span class="__cf_email__" data-cfemail="f19a9487989fdf93909eb184928297df949584">[email&#160;protected]</span></a>聽Kate Peterson (CRC)聽<a href="/cdn-cgi/l/email-protection#eb808a9f8ec59b8e9f8e99988485ab9e88988dc58e8f9e" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="4f242e3b2a613f2a3b2a3d3c20210f3a2c3c29612a2b3a">[email&#160;protected]</span></a>聽聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><img alt="" height="83" src="/sites/g/files/tkssra6046/f/wysiwyg/PROSPER_sunset_squeezedv2.png" style="float:left" width="300" /></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><a href="https://clinicaltrials.gov/study/NCT06401707"><strong>PeRampanel fOr Status ePilEpticus pRophylaxis post-cardiac arrest</strong></a>聽<strong>(NCT06401707 - CWR)</strong></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">PROSPER聽is a randomized clinical trial investigating the safety and feasibility of using perampanel (AMPA receptor antagonist) for post-cardiac arrest refractory status epilepticus prevention.</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Contact: Edilberto Amorim, MD (PI)聽<a href="/cdn-cgi/l/email-protection#1b7a76746972765b6e78687d357e7f6e" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="2c4d41435e45416c594f5f4a02494859">[email&#160;protected]</span></a>聽 Kevin Bao (CRC) <a href="/cdn-cgi/l/email-protection#036866756a6d2d61626c43766070652d666776"><span class="__cf_email__" data-cfemail="b4dfd1c2ddda9ad6d5dbf4c1d7c7d29ad1d0c1">[email&#160;protected]</span></a></p> <h5 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</h5> <h5 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><strong>INDICT</strong></h5> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><strong>Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (NCT05337618 - DOD聽W81XWH-21-C-0075</strong><strong>)</strong></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">This is a randomized Phase 2 feasibility trial that uses real-time spreading depolarization聽monitoring to guide the implementation of a tier-based protocol of intensive care therapies aimed at spreading depolarization suppression, which can include the use of ketamine infusions.</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Contact: Edilberto Amorim, MD (Patient Monitoring Coordination)聽<a href="/cdn-cgi/l/email-protection#a2c3cfcdd0cbcfe2d7c1d1c48cc7c6d7" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="1a7b77756873775a6f79697c347f7e6f">[email&#160;protected]</span></a>聽Anthony DiGiorgio (UCSF PI)</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Prospective Observational Studies</h1> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><img alt="" height="155" src="/sites/g/files/tkssra6046/f/wysiwyg/NEPTUNE_logo_draft.png" style="float:left" width="300" /></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</h1> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</h1> <p style="margin-left:1pt;">聽</p> <p style="margin-left:1pt;"><strong>NEurophysiology of Post-Traumatic epilepsy: UNraveling Epileptogenesis signals (DOD EP220036)</strong></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">This prospective observational study is focused on determining neurophysiology聽biomarkers of epilepsy in patients with traumatic brain injury undergoing invasive monitoring with electrocorticography. There is emphasis on computational analysis of spike data and spreading depolarizations.</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Contact: Edilberto Amorim, MD (PI)聽<a href="/cdn-cgi/l/email-protection#c2a3afadb0abaf82b7a1b1a4eca7a6b7" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="b8d9d5d7cad1d5f8cddbcbde96dddccd">[email&#160;protected]</span></a>聽 Kevin Bao (CRC) <a href="/cdn-cgi/l/email-protection#4d26283b2423632f2c220d382e3e2b63282938"><span class="__cf_email__" data-cfemail="026967746b6c2c60636d42776171642c676677">[email&#160;protected]</span></a></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><strong>NEPTUNE-BIO (DOD EP240055)</strong></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">This prospective observational study is focused on determining neuronal and astrocytic injury blood聽biomarkers of epilepsy in patients with traumatic brain injury undergoing invasive monitoring with electrocorticography. The blood biomarkers include GFAP, Nf-L, UCH-L1,聽Tau, and other biomarkers.</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Contact: Edilberto Amorim, MD (PI)聽<a href="/cdn-cgi/l/email-protection#83e2eeecf1eaeec3f6e0f0e5ade6e7f6" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="92f3fffde0fbffd2e7f1e1f4bcf7f6e7">[email&#160;protected]</span></a>聽 Kevin Bao (CRC) <a href="/cdn-cgi/l/email-protection#4f242a392621612d2e200f3a2c3c29612a2b3a"><span class="__cf_email__" data-cfemail="4a212f3c232464282b250a3f29392c642f2e3f">[email&#160;protected]</span></a></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><img alt="" height="183" src="/sites/g/files/tkssra6046/f/wysiwyg/TARGET-MAP%20logo_EA.png" style="float:left" width="300" /></p> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</h1> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</h1> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><strong>Transcranial doppler AutoReGulation assessment of brain perfusion in nEurocritical patients for MAP optimization (AHA 24DIVSUP1274116)</strong></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">This prospective observational study is focused on estimating the optimal cerebral perfusion pressure using robotic continuous and bilateral transcranial Doppler in acute brain injury, wich a focus on post-cardiac arrest. We will specifically investigate end-organ perfusion using EEG.</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Contact: Marina Marques, MD聽(PI) and Edilberto Amorim, MD (PI) <a href="/cdn-cgi/l/email-protection#5934382b282c3c2a192c3a2a3f773c3d2c662a2c3b333c3a2d640d180b1e1c0d74141809"><span class="__cf_email__" data-cfemail="bbd6dac9cacedec8fbced8c8dd95dedfce">[email&#160;protected]</span></a>聽<a href="/cdn-cgi/l/email-protection#b0d1dddfc2d9ddf0c5d3c3d69ed5d4c5" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="f1909c9e83989cb184928297df949584">[email&#160;protected]</span></a>聽 Kevin Bao (CRC) <a href="/cdn-cgi/l/email-protection#bad1dfccd3d494d8dbd5facfd9c9dc94dfdecf"><span class="__cf_email__" data-cfemail="28434d5e4146064a4947685d4b5b4e064d4c5d">[email&#160;protected]</span></a></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">聽</p> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><strong>SPARE</strong></h1> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><strong>Addressing an inherent bias in neuroprognostication: A collaboration between the US and Brazil to reduce the impact of Self-fulfilling Prophecy in cardiac ARrEst (R01NS128342</strong><strong>)</strong></p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">The framework for prognostication after cardiac arrest may be聽biased by withdrawal of life-sustaining therapies (WLST) due to perceived poor neurological prognosis. This joint study between medical centers in the US and Brazil will compare comprehensive patient assessments in both countries to examine the effect of WLST bias.</p> <p paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Contact: Edilberto Amorim, MD (UCSF PI)聽<a href="/cdn-cgi/l/email-protection#284945475a4145685d4b5b4e064d4c5d" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="51303c3e23383c11243222377f343524">[email&#160;protected]</span></a>聽</p> <h1>聽</h1> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071">Multicenter Studies</h1> <h1 paraeid="{33cc9766-37d2-4105-bea4-1ceab8a87e47}{42}" paraid="340996071"><img alt="" height="101" src="/sites/g/files/tkssra6046/f/wysiwyg/chorus_ai_for_website.png" style="float:left" width="400" /></h1> <p>聽</p> <p>聽</p> <h1>聽</h1> <p>聽</p> <p><strong><a href="https://chorus4ai.org/">Patient-Focused Collaborative Hospital Repository Uniting Standards for Equitable AI</a>聽(1OT2OD032701-01)</strong></p> <p>CHORUS聽will develop the necessary network, tools, standards, data, and education to build machine-learning (ML) and artificial intelligence (AI)-derived models to improve the care and outcomes of patients requiring critical care.聽</p> <p>Contact: Edilberto Amorim, MD (UCSF PI)聽<a href="/cdn-cgi/l/email-protection#0f6e62607d66624f7a6c7c69216a6b7a" rel="noreferrer noopener" target="_blank"><span class="__cf_email__" data-cfemail="8dece0e2ffe4e0cdf8eefeeba3e8e9f8">[email&#160;protected]</span></a>聽</p> <h1>聽</h1> <h1>Datasets</h1> <p><strong>I-CARE: The聽International Cardiac Arrest REsearch consortium</strong></p> <p><strong>Open Data for Coma Research using AI for time-series multichannel waveform data:聽</strong>In partnership with the Brain Data Science Platform and the AHA Precision Medicine Platform, we have curated the largest disease-specific clinical and EEG database for cardiac arrest. This data can be accessed by outside UCSF through聽<a href="https://physionet.org/content/i-care/2.0/">Physionet </a>and聽<a href="https://bdsp.io/">BDSP</a>聽and is being used at the CinC 2023 Hackathon.</p> <figure class="image" style="float:left"><img alt="" height="267" src="/sites/g/files/tkssra6046/f/wysiwyg/ICARE_Fig_1-Page-1.drawio.png" width="900" /> <figcaption><br /> BIDMC: Beth Israel Deaconess Medical Center; BWH: Brigham and Women鈥檚 Hospital; MGH: Massachusetts General Hospital; Yale: Yale New Haven Medical Center, UTW: University of Twente (Medisch Spectrum Twente); RJN: Rinjstate Hospital; ULB: Universit茅 Libre de Bruxelles (Erasme Hospital); ICU: Intensive care unit; EDF+: European Data Format; WFDB: Waveform Database; BDSP: Brain Data Science Platform; S3: Simple Storage Service.</figcaption> </figure> <p>聽</p> <p>聽</p> <p>聽</p> <p>聽</p> <p>聽</p> <p>聽</p> <p>聽</p> <p><br /> 聽</p> </div></div></div> </div> </div> </div> </div> </div> </div> </div> <div id="sidebar" class="column"> </div> </div></div> <div id="footer"> <div class="section"> <div class="footer-bottom"> <nav aria-label="Footer Navigation" class="footer--navigation"> <ul> <li><a href="/cdn-cgi/l/email-protection#77161a18051e1a370214041159121302">Contact Us</a></li> <li><a href="https://www.ucsf.edu/accessibility-resources">Accessibility</a></li> <li><a href="https://www.ucsf.edu/website-privacy-policy">Privacy Policy</a></li> <li><a href="https://websites.ucsf.edu/website-terms-use">Terms of Use </a></li> <li><a href="https://websites.ucsf.edu/azlist">A-Z Website List</a></li> </ul> </nav> <div class="footer--copyright"> <p>&copy; 2024 The Regents of the University of California</p> </div> </div> </div> </div> </div> </div> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="text/javascript"> /*<![CDATA[*/ (function() { var sz = document.createElement('script'); sz.type = 'text/javascript'; sz.async = true; sz.src = '//siteimproveanalytics.com/js/siteanalyze_8343.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(sz, s); })(); /*]]>*/ </script> </body> </html>

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