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>Contact</span></a></li> </ul></nav></div></section> </div><div class="breadcrumb"><span class="breadcrumb-link-wrap"><a href="https://www.thermofisher.com/blog/?">Accelerating Science</a></span><span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/biotechnology/"><span class="breadcrumb-link-text-wrap">Biotech at Scale</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/biotechnology/clinical-trials/"><span class="breadcrumb-link-text-wrap">Clinical Trials</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">Cells, Made to Order: BlueRock and the Stem Cell Therapy Revolution</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-155 post type-post status-publish format-standard has-post-thumbnail category-clinical-trials division-bid entry" aria-label="Cells, Made to Order: BlueRock and the Stem Cell Therapy Revolution"><header class="entry-header"><h1 class="entry-title">Cells, Made to Order: BlueRock and the Stem Cell Therapy Revolution</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/biotechnology/tf-author/ainslie-little-as-interviewed-by-thermo-fisher-scientific/" title="Posts by Ainslie Little as Interviewed by Thermo Fisher Scientific" rel="author">Ainslie Little as Interviewed by Thermo Fisher Scientific, </a> </span> <span class="post-info-date"> 10.04.2023 </span> </header><div class="entry-content"> <hr class="wp-block-separator has-alpha-channel-opacity"/> <p><a id="_msocom_1"></a></p> <figure class="wp-block-image size-large"><img decoding="async" width="1024" height="576" src="https://www.thermofisher.com/blog/biotechnology/wp-content/uploads/sites/24/2023/09/Screenshot-2023-09-01-at-2.20.32-PM-1024x576.png" alt="" class="wp-image-127" srcset="https://www.thermofisher.com/blog/biotechnology/wp-content/uploads/sites/24/2023/09/Screenshot-2023-09-01-at-2.20.32-PM-1024x576.png 1024w, https://www.thermofisher.com/blog/biotechnology/wp-content/uploads/sites/24/2023/09/Screenshot-2023-09-01-at-2.20.32-PM-300x169.png 300w, https://www.thermofisher.com/blog/biotechnology/wp-content/uploads/sites/24/2023/09/Screenshot-2023-09-01-at-2.20.32-PM-768x432.png 768w, https://www.thermofisher.com/blog/biotechnology/wp-content/uploads/sites/24/2023/09/Screenshot-2023-09-01-at-2.20.32-PM-1536x863.png 1536w, https://www.thermofisher.com/blog/biotechnology/wp-content/uploads/sites/24/2023/09/Screenshot-2023-09-01-at-2.20.32-PM-2048x1151.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> <p>Few realms of <a href="https://www.thermofisher.com/ca/en/home/biotech.html">biotechnology</a> promise as much as gene and cell therapy. These fields aim to edit cells to correct disease states and to replace cells killed by degenerative diseases, directly reversing some of the most debilitating and seemingly untreatable conditions humans can have. These promises have been difficult to realize, but technology is reaching the point where some of them are entering clinical use. Firms like <a href="https://www.bluerocktx.com/">BlueRock Therapeutics</a> are at the forefront of this new arena of science.</p> <div id='buzzsprout-large-player-477406'></div><script type='text/javascript' charset='utf-8' src='https://www.buzzsprout.com/2132265/12624420.js?container id=buzzsprout-large-player-477406&player=large'></script> <p>BlueRock’s proposition is simple, as Ainslie Little, their Senior Vice President of Corporate Strategy, presents it: they want to restore health to people whose tissues are degenerating due to genetic disease. To do this, they establish pluripotent stem cell lines, edit their genomes to remove disease-causing mutations, and use those stem cells to rebuild healthy version of the degenerating tissue. When this kind of stem cell therapy works as desired, it physically replaces the dead, damaged, or dying cells that cause the disease with new, healthy cells that do not contain the disease-causing gene variants, which both reverses the disease’s existing effects and cures it going forward. BlueRock’s approach is already showing clinical success, with early trials of <a href="https://parkinsonsnewstoday.com/news/cell-therapy-bemdaneprocel-safe-advanced-parkinsons-clinical-trial/">bemdaneprocel (BRT-DA01)</a>, a cell therapy for Parkinson’s disease, looking positive enough to warrant additional, larger trials. BlueRock’s ambitions are far grander, and Little offers a list of ongoing projects: “We also have programs directed to treatment of lysosomal storage disorders and demyelination diseases…we have a cardiac program where we generate cardiomyocyte cells from pluripotent stem cells in an effort to create a therapeutic that would replace the cells lost in patients with heart failure.” This shows the flexibility of what BlueRock Therapeutics has managed to create: in theory, it amounts to a radical extension of the human body’s natural healing process, able to regenerate tissues lost to virtually any event or condition.</p> <p>One other item shows the extent to which BlueRock’s efforts could be developed: “We also have a couple of programs in our pipeline that target diseases that are not degenerative diseases per se, but diseases where we think delivery of a cell or use of a cell as a delivery vehicle for a payload, for instance, might be advantageous over other more traditional modalities of therapeutic treatment.”</p> <p>BlueRock achieved its success, and builds its ambitions on, a foundation of technologies cleverly developed in-house or licensed from their current owners. In particular, their proprietary system for creating pluripotent stem cells from ordinary cells and maintaining the resulting cell lines is the core of their business plan. Licensing use of CRISPR-Cas9 gene editing technology from Editas Medicine enabled them to form their current core model: creating healthy versions of diseased cells to introduce into patients whose cells are sick.</p> <p>Ainslie Little’s path to BlueRock Therapeutics was as winding as BlueRock’s medical advancements are revolutionary, and is explored in our podcast. <a href="https://www.thermofisher.com/ca/en/home/biotech-lab-solutions/biotech-learning-center/biotech-innovators.html">Listen to this interview and other stories of biotechnology pioneers changing the world at our landing page</a>.</p>  </div></article><section class="author-box"><h4 class="author-box-title">Ainslie Little as Interviewed by Thermo Fisher Scientific</h4><div class="author-box-content" itemprop="description"></div></section> <div id="respond" class="comment-respond"> <h3 id="reply-title" class="comment-reply-title">Leave a Reply <small><a rel="nofollow" id="cancel-comment-reply-link" href="/biotechnology/cells-made-to-order-bluerock-and-the-stem-cell-therapy-revolution/#respond" style="display:none;">Cancel reply</a></small></h3><form action="https://www.thermofisher.com/blog/biotechnology/wp-comments-post.php" method="post" id="commentform" class="comment-form" novalidate><p class="comment-notes"><span id="email-notes">Your email address will not be published.</span> <span class="required-field-message">Required fields are marked <span class="required">*</span></span></p><p class="comment-form-comment"><label for="comment">Comment <span class="required">*</span></label> <textarea id="comment" name="comment" cols="45" rows="8" maxlength="65525" required></textarea></p><p class="comment-form-author"><label for="author">Name <span class="required">*</span></label> <input id="author" name="author" type="text" value="" size="30" maxlength="245" autocomplete="name" required /></p> <p class="comment-form-email"><label for="email">Email <span class="required">*</span></label> <input id="email" name="email" type="email" value="" size="30" maxlength="100" aria-describedby="email-notes" autocomplete="email" required /></p> <p class="comment-form-url"><label for="url">Website</label> <input id="url" name="url" type="url" value="" size="30" maxlength="200" autocomplete="url" /></p> <p class="comment-form-cookies-consent"><input id="wp-comment-cookies-consent" name="wp-comment-cookies-consent" type="checkbox" value="yes" /> <label for="wp-comment-cookies-consent">Save my name, email, and website in this browser for the next time I comment.</label></p> <p class="form-submit"><input name="submit" type="submit" id="submit" class="submit" value="Post Comment" /> <input type='hidden' name='comment_post_ID' value='155' id='comment_post_ID' /> <input type='hidden' name='comment_parent' id='comment_parent' value='0' /> </p><p style="display: none;"><input type="hidden" id="akismet_comment_nonce" name="akismet_comment_nonce" value="988da94321" /></p><p style="display: none !important;" class="akismet-fields-container" data-prefix="ak_"><label>Δ<textarea name="ak_hp_textarea" cols="45" rows="8" maxlength="100"></textarea></label><input type="hidden" id="ak_js_2" name="ak_js" value="61"/><script>document.getElementById( "ak_js_2" ).setAttribute( "value", ( new Date() ).getTime() );</script></p></form> </div> <div class="adjacent-entry-pagination pagination"><div class="pagination-previous alignleft"><i class="fa fa-icon fa-chevron-left"></i> <a href="https://www.thermofisher.com/blog/biotechnology/incubating-the-future-with-medace-for-biotech-startups/" rel="prev">Incubating the Future with Medace for Biotech Startups</a></div><div class="pagination-next alignright"><a href="https://www.thermofisher.com/blog/biotechnology/evolving-medicine-taking-inspiration-from-nature-with-peel-therapeutics/" rel="next">Evolving Medicine: Taking Inspiration from Nature with Peel Therapeutics</a> <i class="fa fa-icon fa-chevron-right"></i></div></div></main></div></div><footer class="site-footer"><div class="wrap"><div class="creds"><p class="footer-links"><a href="https://corporate.thermofisher.com/en/footer/privacy-statement.html" target="_blank" rel="noopener noreferrer">Privacy Statement</a><a href="https://corporate.thermofisher.com/en/footer/terms-and-conditions.html" target="_blank" rel="noopener noreferrer">Terms & Conditions</a><a href="/blog/locations/">Locations</a><a href="/blog/sitemap/">Sitemap</a></p><p>© 2024 <a href="https://www.thermofisher.com">Thermo Fisher Scientific</a>. 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