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Fattore di trascrizione - Wikipedia

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class="vector-toc-link" href="#Collegamenti_esterni"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Collegamenti esterni</span> </div> </a> <ul id="toc-Collegamenti_esterni-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Indice" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Mostra/Nascondi l&#039;indice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled 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Disponibile in 39 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-39" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">39 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B9%D8%A7%D9%85%D9%84_%D9%86%D8%B3%D8%AE" title="عامل نسخ - arabo" lang="ar" hreflang="ar" data-title="عامل نسخ" data-language-autonym="العربية" data-language-local-name="arabo" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Transkripcijski_faktor" title="Transkripcijski faktor - bosniaco" lang="bs" hreflang="bs" data-title="Transkripcijski faktor" data-language-autonym="Bosanski" data-language-local-name="bosniaco" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Factor_de_transcripci%C3%B3" title="Factor de transcripció - catalano" lang="ca" hreflang="ca" data-title="Factor de transcripció" data-language-autonym="Català" data-language-local-name="catalano" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Transkrip%C4%8Dn%C3%AD_faktor" title="Transkripční faktor - ceco" lang="cs" hreflang="cs" data-title="Transkripční faktor" data-language-autonym="Čeština" data-language-local-name="ceco" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Transskriptionsfaktor" title="Transskriptionsfaktor - danese" lang="da" hreflang="da" data-title="Transskriptionsfaktor" data-language-autonym="Dansk" data-language-local-name="danese" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Transkriptionsfaktor" title="Transkriptionsfaktor - tedesco" lang="de" hreflang="de" data-title="Transkriptionsfaktor" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A0%CE%B1%CF%81%CE%AC%CE%B3%CE%BF%CE%BD%CF%84%CE%B1%CF%82_%CE%BC%CE%B5%CF%84%CE%B1%CE%B3%CF%81%CE%B1%CF%86%CE%AE%CF%82" title="Παράγοντας μεταγραφής - greco" lang="el" hreflang="el" data-title="Παράγοντας μεταγραφής" data-language-autonym="Ελληνικά" data-language-local-name="greco" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Transcription_factor" title="Transcription factor - inglese" lang="en" hreflang="en" data-title="Transcription factor" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Transskribfaktoro" title="Transskribfaktoro - esperanto" lang="eo" hreflang="eo" data-title="Transskribfaktoro" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Factor_de_transcripci%C3%B3n" title="Factor de transcripción - spagnolo" lang="es" hreflang="es" data-title="Factor de transcripción" data-language-autonym="Español" data-language-local-name="spagnolo" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Transkriptsioonifaktor" title="Transkriptsioonifaktor - estone" lang="et" hreflang="et" data-title="Transkriptsioonifaktor" data-language-autonym="Eesti" data-language-local-name="estone" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%81%D8%A7%DA%A9%D8%AA%D9%88%D8%B1_%D8%B1%D9%88%D9%86%D9%88%DB%8C%D8%B3%DB%8C" title="فاکتور رونویسی - persiano" lang="fa" hreflang="fa" data-title="فاکتور رونویسی" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Transkriptiotekij%C3%A4" title="Transkriptiotekijä - finlandese" lang="fi" hreflang="fi" data-title="Transkriptiotekijä" data-language-autonym="Suomi" data-language-local-name="finlandese" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Facteur_de_transcription" title="Facteur de transcription - francese" lang="fr" hreflang="fr" data-title="Facteur de transcription" data-language-autonym="Français" data-language-local-name="francese" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Factor_de_transcrici%C3%B3n" title="Factor de transcrición - galiziano" lang="gl" hreflang="gl" data-title="Factor de transcrición" data-language-autonym="Galego" data-language-local-name="galiziano" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%92%D7%95%D7%A8%D7%9D_%D7%A9%D7%A2%D7%AA%D7%95%D7%A7" title="גורם שעתוק - ebraico" lang="he" hreflang="he" data-title="גורם שעתוק" data-language-autonym="עברית" data-language-local-name="ebraico" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Transkripcijski_%C4%8Dimbenik" title="Transkripcijski čimbenik - croato" lang="hr" hreflang="hr" data-title="Transkripcijski čimbenik" data-language-autonym="Hrvatski" data-language-local-name="croato" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Transzkripci%C3%B3s_faktor" title="Transzkripciós faktor - ungherese" lang="hu" hreflang="hu" data-title="Transzkripciós faktor" data-language-autonym="Magyar" data-language-local-name="ungherese" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Faktor_transkripsi" title="Faktor transkripsi - indonesiano" lang="id" hreflang="id" data-title="Faktor transkripsi" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonesiano" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E8%BB%A2%E5%86%99%E5%9B%A0%E5%AD%90" title="転写因子 - giapponese" lang="ja" hreflang="ja" data-title="転写因子" data-language-autonym="日本語" data-language-local-name="giapponese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%A2%E1%83%A0%E1%83%90%E1%83%9C%E1%83%A1%E1%83%99%E1%83%A0%E1%83%98%E1%83%A4%E1%83%AA%E1%83%98%E1%83%98%E1%83%A1_%E1%83%A4%E1%83%90%E1%83%A5%E1%83%A2%E1%83%9D%E1%83%A0%E1%83%94%E1%83%91%E1%83%98" title="ტრანსკრიფციის ფაქტორები - georgiano" lang="ka" hreflang="ka" data-title="ტრანსკრიფციის ფაქტორები" data-language-autonym="ქართული" data-language-local-name="georgiano" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%A0%84%EC%82%AC%EC%9D%B8%EC%9E%90" title="전사인자 - coreano" lang="ko" hreflang="ko" data-title="전사인자" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Factor_transcriptionis" title="Factor transcriptionis - latino" lang="la" hreflang="la" data-title="Factor transcriptionis" data-language-autonym="Latina" data-language-local-name="latino" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Transcriptiefactor" title="Transcriptiefactor - olandese" lang="nl" hreflang="nl" data-title="Transcriptiefactor" data-language-autonym="Nederlands" data-language-local-name="olandese" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Transkripsjonsfaktor" title="Transkripsjonsfaktor - norvegese bokmål" lang="nb" hreflang="nb" data-title="Transkripsjonsfaktor" data-language-autonym="Norsk bokmål" data-language-local-name="norvegese bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Factor_de_transcripcion" title="Factor de transcripcion - occitano" lang="oc" hreflang="oc" data-title="Factor de transcripcion" data-language-autonym="Occitan" data-language-local-name="occitano" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Czynnik_transkrypcyjny" title="Czynnik transkrypcyjny - polacco" lang="pl" hreflang="pl" data-title="Czynnik transkrypcyjny" data-language-autonym="Polski" data-language-local-name="polacco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Fator_de_transcri%C3%A7%C3%A3o" title="Fator de transcrição - portoghese" lang="pt" hreflang="pt" data-title="Fator de transcrição" data-language-autonym="Português" data-language-local-name="portoghese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%82%D1%80%D0%B0%D0%BD%D1%81%D0%BA%D1%80%D0%B8%D0%BF%D1%86%D0%B8%D0%B8" title="Факторы транскрипции - russo" lang="ru" hreflang="ru" data-title="Факторы транскрипции" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Transkripcioni_faktor" title="Transkripcioni faktor - serbo-croato" lang="sh" hreflang="sh" data-title="Transkripcioni faktor" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Transcription_factor" title="Transcription factor - Simple English" lang="en-simple" hreflang="en-simple" data-title="Transcription factor" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Transkrip%C4%8Dn%C3%BD_faktor" title="Transkripčný faktor - slovacco" lang="sk" hreflang="sk" data-title="Transkripčný faktor" data-language-autonym="Slovenčina" data-language-local-name="slovacco" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Prepisovalni_dejavnik" title="Prepisovalni dejavnik - sloveno" lang="sl" hreflang="sl" data-title="Prepisovalni dejavnik" data-language-autonym="Slovenščina" data-language-local-name="sloveno" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Transkripcioni_faktor" title="Transkripcioni faktor - serbo" lang="sr" hreflang="sr" data-title="Transkripcioni faktor" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Transkriptionsfaktor" title="Transkriptionsfaktor - svedese" lang="sv" hreflang="sv" data-title="Transkriptionsfaktor" data-language-autonym="Svenska" data-language-local-name="svedese" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Transkripsiyon_fakt%C3%B6r%C3%BC" title="Transkripsiyon faktörü - turco" lang="tr" hreflang="tr" data-title="Transkripsiyon faktörü" data-language-autonym="Türkçe" data-language-local-name="turco" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D0%B8_%D1%82%D1%80%D0%B0%D0%BD%D1%81%D0%BA%D1%80%D0%B8%D0%BF%D1%86%D1%96%D1%97" title="Фактори транскрипції - ucraino" lang="uk" hreflang="uk" data-title="Фактори транскрипції" data-language-autonym="Українська" data-language-local-name="ucraino" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Y%E1%BA%BFu_t%E1%BB%91_phi%C3%AAn_m%C3%A3" title="Yếu tố phiên mã - vietnamita" lang="vi" hreflang="vi" data-title="Yếu tố phiên mã" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamita" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%BD%AC%E5%BD%95%E5%9B%A0%E5%AD%90" title="转录因子 - cinese" lang="zh" hreflang="zh" data-title="转录因子" data-language-autonym="中文" data-language-local-name="cinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q407384#sitelinks-wikipedia" title="Modifica collegamenti interlinguistici" class="wbc-editpage">Modifica collegamenti</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespace"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a 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href="/w/index.php?title=Speciale:QrCode&amp;url=https%3A%2F%2Fit.wikipedia.org%2Fwiki%2FFattore_di_trascrizione"><span>Scarica codice QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Stampa/esporta </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Speciale:Libro&amp;bookcmd=book_creator&amp;referer=Fattore+di+trascrizione"><span>Crea un libro</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Speciale:DownloadAsPdf&amp;page=Fattore_di_trascrizione&amp;action=show-download-screen"><span>Scarica come PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Fattore_di_trascrizione&amp;printable=yes" title="Versione stampabile di questa pagina [p]" accesskey="p"><span>Versione 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id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Aspetto"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Aspetto</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">nascondi</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Da Wikipedia, l&#039;enciclopedia libera.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="it" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r133964453">.mw-parser-output .avviso .mbox-text-div>div,.mw-parser-output .avviso .mbox-text-full-div>div{font-size:90%}.mw-parser-output .avviso .mbox-image{flex-basis:52px;flex-grow:0;flex-shrink:0}.mw-parser-output .avviso .mbox-text-full-div .hide-when-compact{display:block}</style><div style="" class="ambox metadata noprint plainlinks avviso avviso-generico"> <div class="avviso-immagine mbox-image noprint"><span typeof="mw:File"><a href="/wiki/File:DNA.png" class="mw-file-description" title="Abbozzo biologia molecolare"><img alt="Abbozzo biologia molecolare" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/DNA.png/43px-DNA.png" decoding="async" width="43" height="45" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/DNA.png/65px-DNA.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/47/DNA.png/85px-DNA.png 2x" data-file-width="298" data-file-height="314" /></a></span></div> <div class="avviso-testo mbox-text"> <div class="mbox-text-div"><b>Questa voce &#32;sull'argomento biologia molecolare è solo un <a href="/wiki/Aiuto:Abbozzo" title="Aiuto:Abbozzo">abbozzo</a></b>.<br /> <div style="font-size:90%;"><a class="external text" href="https://it.wikipedia.org/w/index.php?title=Fattore_di_trascrizione&amp;action=edit">Contribuisci</a> a migliorarla secondo le <a href="/wiki/Aiuto:Manuale_di_stile" title="Aiuto:Manuale di stile">convenzioni di Wikipedia</a>. Segui i suggerimenti del <a href="/wiki/Progetto:Biologia_molecolare" class="mw-redirect" title="Progetto:Biologia molecolare">progetto di riferimento</a>.</div> <div class="hide-when-compact"> </div> </div> </div> </div> <p>Un <b>fattore di trascrizione</b> è una proteina che lega il <a href="/wiki/DNA" title="DNA">DNA</a> in una regione specifica di un <a href="/wiki/Promotore_(biologia)" title="Promotore (biologia)">promotore</a> o di un <a href="/wiki/Enhancer" title="Enhancer">enhancer</a>, da dove poi regola la <a href="/wiki/Trascrizione_(biologia)" title="Trascrizione (biologia)">trascrizione</a>. I fattori di trascrizione possono essere attivati o disattivati selettivamente da altre proteine, spesso come passo finale della <a href="/wiki/Trasduzione_del_segnale" title="Trasduzione del segnale">trasduzione</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Classi">Classi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;veaction=edit&amp;section=1" title="Modifica la sezione Classi" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;action=edit&amp;section=1" title="Edit section&#039;s source code: Classi"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Ci sono 3 classi di fattori di trascrizione: </p> <ul><li>Fattori di trascrizione generali: sono coinvolti nel processo di preiniziazione. Sono ubiquitari e interagiscono con la regione <i>core</i> del promotore sormontando il sito/i d'inizio della trascrizione di tutti i <a href="/wiki/Gene" title="Gene">geni</a> di classe II. I più studiati sono i seguenti: <ul><li><a href="/wiki/TFIIA" title="TFIIA">TFIIA</a> (geni <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2A1">GTF2A1</a></i> e <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2A2">GTF2A2</a></i>);</li> <li><a href="/w/index.php?title=TFIIB&amp;action=edit&amp;redlink=1" class="new" title="TFIIB (la pagina non esiste)">TFIIB</a> (<i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2B">GTF2B</a></i>);</li> <li><a href="/w/index.php?title=TFIID&amp;action=edit&amp;redlink=1" class="new" title="TFIID (la pagina non esiste)">TFIID</a> (<i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=TBP">TBP</a></i>, <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=BTAF1">BTAF1</a></i> e <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=TAF9B">TAF9B</a></i>);</li> <li><a href="/w/index.php?title=TFIIE&amp;action=edit&amp;redlink=1" class="new" title="TFIIE (la pagina non esiste)">TFIIE</a> (<i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2E1">GTF2E1</a></i> e <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2E2">GTF2E2</a></i>);</li> <li><a href="/w/index.php?title=TFIIF&amp;action=edit&amp;redlink=1" class="new" title="TFIIF (la pagina non esiste)">TFIIF</a> (<i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2F1">GTF2F1</a></i>, <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2F2">GTF2F2</a></i> e <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2F2L">GTF2F2L</a></i>);</li> <li><a href="/w/index.php?title=TFIIH&amp;action=edit&amp;redlink=1" class="new" title="TFIIH (la pagina non esiste)">TFIIH</a> (<i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=ERCC3">ERCC3</a></i>, <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2H2">GTF2H2</a></i> e <i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=GTF2H3">GTF2H3</a></i>);</li> <li><a href="/w/index.php?title=NC2&amp;action=edit&amp;redlink=1" class="new" title="NC2 (la pagina non esiste)">NC2</a>, fattore inibitorio (<i><a rel="nofollow" class="external text" href="http://www.genenames.org/data/hgnc_data.php?match=DR1">DR1</a></i>).</li></ul></li> <li>Fattori di trascrizione <i>Upstream</i>: sono proteine che legano siti a monte del sito di iniziazione e stimolano o reprimono la trascrizione.</li> <li>Fattori di trascrizione inducibili: sono simili agli Upstream ma richiedono attivazione o inibizione.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Strutture">Strutture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;veaction=edit&amp;section=2" title="Modifica la sezione Strutture" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;action=edit&amp;section=2" title="Edit section&#039;s source code: Strutture"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Motivi trovati nei Fattori di trascrizione sono: </p> <ul><li><a href="/wiki/Elica-Giro-Elica" class="mw-redirect" title="Elica-Giro-Elica">Elica-Giro-Elica</a> (Helix-turn-helix/HTH): legano l'ansa maggiore del <a href="/wiki/DNA" title="DNA">DNA</a>.</li> <li><a href="/wiki/Dito_di_zinco" title="Dito di zinco">Dita di Zinco</a> (Zn finger): servono da piattaforma strutturale per legare il <a href="/wiki/DNA" title="DNA">DNA</a>.</li> <li><a href="/wiki/Cerniera_di_leucine" title="Cerniera di leucine">Cerniera di leucine</a> (Leucine Zipper): associa diversi fattori di trascrizione tra di loro.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Altri_progetti">Altri progetti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;veaction=edit&amp;section=3" title="Modifica la sezione Altri progetti" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;action=edit&amp;section=3" title="Edit section&#039;s source code: Altri progetti"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div id="interProject" class="toccolours" style="display: none; clear: both; margin-top: 2em"><p id="sisterProjects" style="background-color: #efefef; color: black; font-weight: bold; margin: 0"><span>Altri progetti</span></p><ul title="Collegamenti verso gli altri progetti Wikimedia"> <li class="" title=""><span class="plainlinks" title="commons:Category:Transcription factors"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Transcription_factors?uselang=it">Wikimedia Commons</a></span></li></ul></div> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/?uselang=it" title="Collabora a Wikimedia Commons"><img alt="Collabora a Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png" decoding="async" width="18" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/27px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/36px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/?uselang=it">Wikimedia Commons</a></span> contiene immagini o altri file sul <b><span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Transcription_factors?uselang=it">fattore di trascrizione</a></span></b></li></ul> <div class="mw-heading mw-heading2"><h2 id="Collegamenti_esterni">Collegamenti esterni</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;veaction=edit&amp;section=4" title="Modifica la sezione Collegamenti esterni" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Fattore_di_trascrizione&amp;action=edit&amp;section=4" title="Edit section&#039;s source code: Collegamenti esterni"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li class="mw-empty-elt"></li> <li><cite id="CITEREFEnciclopedia_della_scienza_e_della_tecnica" class="citation libro" style="font-style:normal"> Roberto di Lauro e Mariastella Zannini, <a rel="nofollow" class="external text" href="https://www.treccani.it/enciclopedia/fattori-di-trascrizione_(Enciclopedia-della-Scienza-e-della-Tecnica)/"><span style="font-style:italic;">Fattori di trascrizione</span></a>, in <span style="font-style:italic;">Enciclopedia della scienza e della tecnica</span>, <a href="/wiki/Istituto_dell%27Enciclopedia_Italiana" title="Istituto dell&#39;Enciclopedia Italiana">Istituto dell'Enciclopedia Italiana</a>, 2007-2008.</cite> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q407384#P10037" title="Modifica su Wikidata"><img alt="Modifica su Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></li> <li><cite id="CITEREFDizionario_di_medicina" class="citation libro" style="font-style:normal"> <a rel="nofollow" class="external text" href="https://www.treccani.it/enciclopedia/fattore-di-trascrizione_(Dizionario-di-Medicina)/"><span style="font-style:italic;">Fattore di trascrizione</span></a>, in <span style="font-style:italic;">Dizionario di medicina</span>, <a href="/wiki/Istituto_dell%27Enciclopedia_Italiana" title="Istituto dell&#39;Enciclopedia Italiana">Istituto dell'Enciclopedia Italiana</a>, 2010.</cite> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q407384#P10022" title="Modifica su Wikidata"><img alt="Modifica su Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></li> <li><cite id="CITEREFBritannica.com" class="citation web" style="font-style:normal">(<span style="font-weight:bolder; font-size:80%"><abbr title="inglese">EN</abbr></span>) John A. Cooper, <a rel="nofollow" class="external text" href="https://www.britannica.com/science/transcription-factor"><span style="font-style:italic;">transcription factor</span></a>, su <span style="font-style:italic;"><a href="/wiki/Enciclopedia_Britannica" title="Enciclopedia Britannica">Enciclopedia Britannica</a></span>, Encyclopædia Britannica, Inc.</cite> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q407384#P1417" title="Modifica su Wikidata"><img alt="Modifica su Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></li> <li><cite id="CITEREFOpen_Library" class="citation web" style="font-style:normal">(<span style="font-weight:bolder; font-size:80%"><abbr title="inglese">EN</abbr></span>) <a rel="nofollow" class="external text" href="https://openlibrary.org/subjects/transcription_factors"><span style="font-style:italic;">Opere riguardanti Transcription Factors</span></a>, su <span style="font-style:italic;"><a href="/wiki/Open_Library" class="mw-redirect" title="Open Library">Open Library</a></span>, <a href="/wiki/Internet_Archive" title="Internet Archive">Internet Archive</a>.</cite> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q407384#P3847" title="Modifica su Wikidata"><img alt="Modifica su Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></li></ul> <style data-mw-deduplicate="TemplateStyles:r141815314">.mw-parser-output .navbox{border:1px solid #aaa;clear:both;margin:auto;padding:2px;width:100%}.mw-parser-output .navbox th{padding-left:1em;padding-right:1em;text-align:center}.mw-parser-output .navbox>tbody>tr:first-child>th{background:#ccf;font-size:90%;width:100%;color:var(--color-base,black)}.mw-parser-output .navbox_navbar{float:left;margin:0;padding:0 10px 0 0;text-align:left;width:6em}.mw-parser-output .navbox_title{font-size:110%}.mw-parser-output .navbox_abovebelow{background:#ddf;font-size:90%;font-weight:normal}.mw-parser-output .navbox_group{background:#ddf;font-size:90%;padding:0 10px;white-space:nowrap}.mw-parser-output .navbox_list{font-size:90%;width:100%}.mw-parser-output .navbox_list a{white-space:nowrap}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_odd{background:#fdfdfd;color:var(--color-base,black)}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_even{background:#f7f7f7;color:var(--color-base,black)}.mw-parser-output .navbox a.mw-selflink{color:var(--color-base,black)}.mw-parser-output .navbox_center{text-align:center}.mw-parser-output .navbox .navbox_image{padding-left:7px;vertical-align:middle;width:0}.mw-parser-output .navbox+.navbox{margin-top:-1px}.mw-parser-output .navbox .mw-collapsible-toggle{font-weight:normal;text-align:right;width:7em}body.skin--responsive .mw-parser-output .navbox_image img{max-width:none!important}.mw-parser-output .subnavbox{margin:-3px;width:100%}.mw-parser-output .subnavbox_group{background:#e6e6ff;padding:0 10px}@media screen{html.skin-theme-clientpref-night .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-night .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-night .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-os .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-os .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}</style><table class="navbox mw-collapsible mw-collapsed noprint metadata" id="navbox-Biologia_molecolare"><tbody><tr><th colspan="3"><div class="navbox_navbar"><div class="noprint plainlinks" style="background-color:transparent; 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