CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.science.org",cType: 'managed',cRay: '8ea8d8b8ff745fd9',cH: '5yRddORvrbyDdqFg0jmFzpJKG61k8OUfO5p2a3lehTA-1732948832-1.2.1.1-tKXjJOtQhe4t0c_sKhvGZQpggAeyNsslx2DbDkMGGyvSvV4rsvKkqfmHWeUviXAP',cUPMDTk: "\/doi\/10.1126\/sciadv.aau5363?__cf_chl_tk=Dpe6qPl7JKbN0MWVVS8iK3CODwhfj9urXJreNs73ne0-1732948832-1.0.1.1-6OrWB1JatiQaj7auZhdj.N2V08_TGUwR3Zpv8cTKq7k",cFPWv: 'b',cITimeS: '1732948832',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1126\/sciadv.aau5363?__cf_chl_f_tk=Dpe6qPl7JKbN0MWVVS8iK3CODwhfj9urXJreNs73ne0-1732948832-1.0.1.1-6OrWB1JatiQaj7auZhdj.N2V08_TGUwR3Zpv8cTKq7k",md: "A9WQNjYzv7u25RtHgljbtZ6uV5f.Lzgm.cNWFReBtdU-1732948832-1.2.1.1-2zf7J4GYc4ORaLxPpe.JLXfpIjR81fQjf8hJdjUBbqI4i9q9KxP9o6PkmGGx3LAddSG72RiL361E3ElQhK7gKdoIRCuGzX3_9ed1a6ofPWIH4vldoOEtBO5GuJYhnPdU73LRjOug7LJyEucmMfkeLVdjh2jPRW6eaLAJo4puhuz4rblCWKvI.Wh2DE3eGa9VlJ.iIHvmZjq2Nkna21iJmL1tqh7r2SCNoi_8FVhU.0jbU0oBT1dvHBu29rpNMTOVP0upxvNE.cmZvONvG4kDNgVxq_n9LtAwQXMVQxIlWK7oWA6qSg8W.0V4Lm3O6LpPAejggdmsUZF4sZnNiw9ycxlpU5rhla_K2bSrK72o9QMvsdERB6EdNflcYzSipOAjeKFzKKqlxhY4dyUNP7qYX8TaXUDzp3kfGYjDhBXTxw.09uqYq2ehfydEwGZ_PPIJjKpX4MCBdc.hvSe4NNBug9e1DObDQudBzVlhfdBaAdDxdzlc9rpEqywzH1s2VjhM7bY.8QP2Wujkj7Yra4L3w1d7P4DgwOnhSXIGsiiNv.yfE1vr.Qxh7X17GLb3kJ9t4DDEi6ZPJScneF21diKo1cb1ijIuPfbmQQ1gEI7XkV8wqS7qnLNJ19d5dFJrsp4FICClJXv1fiieay5rqmkpS8SAnoivlQ0RpZ1DYJU6RVjDUK1Ac3ldUzsa0wBp9Kpi355F_jlDIKk7WPG6wAgiyXDa07GpYLXVhzinE_mDNHpZHJFPyKCw9HmRNcPe9ygrXYYPCOlgyXSEp9g947Aq6.ZwcTbOKaLmnwFAHFG2RRlbcE1_9wVqY9_mFQ3Xyd4vFTbGdKD3qz5SntuAi7TKw48j7TcfMOBjewrepahZm1hI.29vMrB_GB5MkUWC.KqpMWtJiU3BW2HDeCTwXcAWVixt0NE5cj6V5RZKFkeTuYK0ftcxRJMdPD0ZkKV0kCah8NMpNfHNuaXpieXUrF6XozkQNWb6DY4IxKKVqbyKXYIdz5o5jl3HLZ5DDACBmGqq8QXIZA4I2jDP1j25NknfzyB8w3VW9wTNlpb9v_wnR8.YLh8fNlu2AxbDbGr.NZrWF7MU01yG0RBkA7N0lLYOKY7evrAJYWDrHB52o8bWO8TC_Dy8lgM94O0fbEiBRC4MFVQx5hoiJv7UElVvLh5bnp9n74mfgmxG5JOmD3H7II4tT.hCop7jteOpaBhsFIKlyvfzvL5IpUlw1CHKU.FINUOG18iEEyMP83AyXuULic1ZLEWODBR8LEVsHkm.tOsRHDscfRbU.EaSzZQyc17rCGnQi7tepqtyOQu8n13_vaarfc4HJsn415uSBX2t9I5TiZ5S3zqu1k9XeUv15UPxSF1ZJ32cADTqVxmsqjXiteDoFtkw1KwWQrRXlynyKeSGhymM9oTKSz5OcBhehIwydSKmJhmAxSWJScSZj6zCPxOPm3JzU3OJfqQ43d4kVlJ44IJgEU5KLSfpqg8vsas0D1a8.FlmcddWILEJWjW2168jK__dYTuj6W9IPyodpacL13Redl8xuWjsMb6nJqng0ZoAOm.XXQ5Bz_Pe_bmK3ePMy2WQEx.exyc2sFRLgVh8T5sNeL9sX5SLx7WICWedsGJpL9BRLeK05kKFcAkcmZhTVrzstJbhciVjE13HrN6DMiC7XcMfYjBJjDJV7R04mkFLQXeq4hdrzQw3b8N8_0dsIpS5_PsAPUn0_Cb7yKWtFg.et7g2OOAkTHKu4C6JKPi4TYTaLV7rf1A38VhTFQKL5H___c0B4XItRzyTU0POdVXdKutfWd3AjcFWTeaE4gagO5mWqj2en4DTSaQYVSjm9ZA0koxSNRLY6SVoj3bkFTs78Qq_QMFozMAlYMPhgMOJbRY9xzOT9UJQ0feK5skCbKSLEAVaQyn0TEndSsInw2pmwCVJiXbjYJy39F8zyhrKbzhg8PZkuasqbYeeeXTqjPxHQEKfKXPx.myOj6KwLPjeiAJPbi.Li33BPvF2EQyHVEO2inColXwqomVjNWer4hiGo8ImWGpD7uoi_1Er9l3Aa863t.atlvAcL2w1urt1k649RPqXgzu.ADiI9FeN_ZEr8AY7DqIdNlg5Ew.oUhgq6xll4DPDWwv.420G3DIegSQ94aCpy3.azGEwQTIeuSZYxDhabWXmpmVyTPGTZsHlGGrZy5uJqeftgGXbg9oYr2081Yu868CgFxpdOsNoldPVnBWO50FKY6GeZZK55scd2RQkz_glBmUpNikxuDAYvxVSGG.NVFqIKsWa.3A2xGiKgRXvawap64p9NE8PbnxKLK_0ZPUcZxL0eh3A4hmw5YUc8KQHxzV7M6_5y0oDIq_8N6uX7mFkBFz3J0tk2V56oKNQ7.cCocigKtNASqf7Ac6AGlVED6Y1pqzGTBXn8PF.S1AuqoByp0CVp3e43lqq.CuS9BgzFGhjViULddgAbvET1GcbEQ6mcuBvZy6V.HIorWEOeLEDvB4eeQ0CKica.b37lUXxqTjS7aDa0apMJHqluoKfKSRwNKlOSdmV3sfowmAAKP_bUGO1BUrTz2XBNGskSx.AEJkyKLBgE.SN_5nkxSb2v6NIEdDY5pkMOtU0XXB4Po7f0ElJkF67G0LrZZ3NMgCt7oFArcM5gpnab2JjO5ECAd8OTW_DJAPwstSUozbDEqBJjF74r.c5jcv7qut1hU3A_eItR8oO3jUmTQHcA0kf6_vxPJNwxQ6Pa_io1VBEXRkjhei6owSLZKSNatiC5Z5GiiM4NI.BYU8HVQ486C7qWq1tTz7PEynOr.s3ozjYKP.855_OMNb9634U0aqE9PdV2M84.tdGAGvYQguhYa8Vgri9PatNbhZpZjq8YGkYuv2M2KwvhydKloHqZD1F9QHaEuECC5ZUZUvHKJeYa_QYYcLT3iyvuqrES.FAplq9bxrQgECJyZM5riGVi1XnTfINmp65DDeV1ZP5BrviNyrIuB4qJJj88UE",mdrd: "Rkx8GY5b3lV2Y8U6HSIy_SdQUNeiC_dswWaF9h2qTPA-1732948832-1.2.1.1-ZFpd350vR6WBSyj2PEbf.WjAb6MEGcS0ntgRMoKunQGFGWMbaEN5SUk8kXTq45RWDobfA6_iZAUJF0XmU7nmbAacNUrDtZCY4z6WiAOmvMq3GEYIVg0UDnV8KjCjy4fc873_py1Xtcn.3uHD.xpU7YLG.bhJjK0JSBJs.O.B6uaqMFTzV8v0oxqJ88fm1CGy91827PRzK5f676UK7UdeBWMS9ubkzSRIr8srPkuuliy6wo9IpBr57rSNcgIL7z3s43Y_aA4R.Ky9iWGZ_MhUoBS36OGsN0jVp5Aiw07zePQ8h_9gl233zRyAkNcxTgOYms51a8k6UK.ejgrHfxL1xbr2aPw1rzV_gbA00ilviWkt0gxP_f0OOM3d60vESI7mnabs52UfpSTewK0ANlHcgaef4aZfgAynvtPXiU2B0In3yYbNzyBXkBIn1o.1J_2v5zxcoPGgZlsr79uAGFBtw1Xx7Tfu0aTxPpzfG4sWANyajup9yzVV_rmpKoUEJZNAggebKxnWnOIj35xjIO8WcDzIq7nzwZu7QNzt6hqwE6uYgQjgKDU0hX_R74lq5EV3bLgGJr8rr9qI1tq1TXaPR_d7qo6CrRloqFz4cMX_6ygMQMzjt1rfxn0D2mvn7J_qMqYu2OTLo13Q3Xg0bW780iCl3ntoNFP9HJYFk8.C09ddEvI7.gvavt_rCNaONztXBabydM.QJXK.e5DLrzRuZ0XYw0SPpJ0UJ4g8WKmeNOqfloNPXtB5fjgujbCBNw56NKBTa.tKGZxaEpOZqiOGMw.LXRR8p.bRC49suHKTcay2YMB3WcrfaLg87TMR25hlexQ78CmmtpPNkA91BuWF4gOfm_CQt2wt1TqLk4qOglm.tWiV4KM1Q2.WcpIZPCNqmJ69l98JerQVuFn7wdoCUpUAl.sYt4FOkszMWZ4kkW6Sg4W_cp9kYhyEVL1diSa8qCzOZWxJHCEm5XoI8Qa8laHd9_Ds2Eawkhm7_8.YVWjMroMxfloOEruN7aboReowyE_pz4RpkKGoCE2Q3w3_B85bRXeDqhzmlTGdj_ym8ZpcWBlRo7ma3wJpVCCce.oQY.DdMKOSx0Nz4Frl.rmywOW_YC_fn6vBlNJr33Odjcwii6cDCYwRpbFcx1jyyVPbwRo0DgxH0JvuAiwUGGeUgIBgniFbu7dagAcOJMHt7MatXNDSJNLEbxcRf5fJT0xmSeTKp5Yzmo7kj7vtHzhGcqfSdo7xfRkYquYC6hCMHVY.pZ0LUYJdwc_kxxSs2N2aJWvJqjafWh_Qwp2wZ3sgzeTWUO9tfgnbq777CWY_KJ4QZm8ljx60Zt2MpDgTkf6.cdWgnwc_HeM_3RDmrvB2peOEyL8atxqej7NIspDF0wnQpGgNN3XfQOIgAVl6ZHNX_N4vdo4.JwPCcarZjZcXaOsKSCm9YI3MO5SP1AcflcK.Z4hsBPCI9N61k4nvXme0rh_JtJ4wy7KfOKU2.Sl9aGmvHMQh7w2sFCQ8o.LRqPWsqgYQnloCURdP2o3JXbdK_uSuKKYK2WpJ_GW_YliHoEI2EEyoBP2riJNCsp.0gK_jsOHOVzmC.JoLryZz4ENL4anJVi_.Cbdd_DF5K4z0XAs6vtfpNgAoSQiNc2KIzaaSOoH_Ndh8xkMVJFej45BkMIYCuYoiK906sKgIzEfjO4SGAdBcC7.8rZpmRg3.CtB10Ft2o9yZYPFqzS25zNa3tB.zOBdPwaVQayLqiFAeBHUh0_kqrGdkaLkZ6RomYT5iBTMKnZLAqeiPluzGGi3yDgSBuH8UxMDzxztaiG_9p5CDuFd7TPUFpkbpvsRxHDqdU7MEiSTvafc.5RxtztFukz_trlHyLQBK2iq8W7r8fdGLjaKpqfbcuFaOC2oNtBWVwPK6YTGZiGCkCVD2kLmrVyI99.qe61F4h58eYObjLGpB6AQzGHVYxD2lYpJ8F_13k_uR0n_G6ysHg2DEo5e9"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8ea8d8b8ff745fd9';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1126\/sciadv.aau5363?__cf_chl_rt_tk=Dpe6qPl7JKbN0MWVVS8iK3CODwhfj9urXJreNs73ne0-1732948832-1.0.1.1-6OrWB1JatiQaj7auZhdj.N2V08_TGUwR3Zpv8cTKq7k" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>