CINXE.COM

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href="https://www.porphyria.ca">Canada</a></li> <li><a href="https://www.lebenmitporphyrie.de">Deutschland</a></li> <li><a href="https://www.cernerlapha.fr/">France</a></li> <li><a href="https://www.livingwithporphyria.eu/">United Kingdom</a></li> </ul> </div> <div class="topLinks"> <a class="btn btn-default patient" href="/hcp">For healthcare professionals</a> <a class="btn btn-default scrollLink" href="#signUpNow">Sign Up</a> </div> </div>  <div class="collapse navbar-collapse" id="porphyriaNav"> <ul class="nav navbar-nav navbar-right"> <li> <a class="nav-anchor" href="/about-ahp">About AHP </a> </li> <li> <a class="nav-anchor" href="/diagnosing-ahp">Diagnosing AHP </a> </li> <li> <a class="nav-anchor" href="/living-with-ahp">Living with AHP </a> </li> <li> <a class="nav-anchor" href="/ahp-treatment-options">Treatment Options </a> </li> <li> <a id="voices-of-ahp-link" class="nav-anchor" href="/patient-stories">Voices of AHP </a> </li> <li class="nav-item dropdown"> <a id="resources-link" class="nav-link dropdown" href="/ahp-resources" aria-haspopup="true" aria-expanded="true">Resources <i class="fas fa-caret-down"></i></a> <div class="dropdown-menu"> <a class="dropdown-item" href="/ahp-resources/doctor-discussion-guide">Doctor Discussion Guide</a> <a class="dropdown-item" href="/ahp-resources/downloadable-resources">Downloadable Resources</a> <a class="dropdown-item" href="/ahp-resources/patient-educators">Connect with an Alnylam Educator</a> <a class="dropdown-item" href="/ahp-resources/programs-and-events">Programs & Events</a> </div> </li> <li class="last"> <a href="/hcp" class=""><span>For healthcare professionals</span></a> <a href="#signUpNow" class="scrollLink"><span>Sign Up</span></a> </li> </ul> </div>  </div>  </nav> </div> </header> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div> <div data-drupal-messages-fallback class="hidden"></div><div id="block-porphyria-content"> <article data-history-node-id="13" role="article" about="/" typeof="schema:WebPage"> <span property="schema:name" content="Patient - Home page" class="hidden"></span> <div> <div class="home"> <main class="patient"> <section class="jumbotron-home"> <div class="container align-bottom"><img alt="" class="img-responsive visible-sm visible-md visible-lg hidden-xs" src="/themes/custom/porphyria/assets/images/patient/home/woman.png" /> <img alt="" class="hidden-sm visible-xs" src="/themes/custom/porphyria/assets/images/patient/home/woman-mobile.png" /></div> <div class="container"> <div class="row"> <div class="jumbotron-text"> <div class="patient-label"><span>–Megan, living with AHP</span></div> <div class="col-xs-12"> <h2 class="headline">It started with nausea,<br class="hidden-sm visible-xs" /> vomiting, and fainting.</h2> <p style="height: 0; margin: 0;"> </p> <h2 class="headline">I was treated for<br class="hidden-sm visible-xs" /> ulcerative colitis.</h2> <p style="height: 0; margin: 0;"> </p> <h2 class="headline">Then endometriosis<br class="hidden-sm visible-xs" /> and depression.</h2> <p style="height: 0; margin: 0;"> </p> <h2 class="headline">They said it was<br class="hidden-sm visible-xs" /> all in my head.</h2> <p style="height: 0; margin: 0;"> </p> <h2 class="headline">It’s not.</h2> <p style="height: 0; margin: 0;"> </p> </div> <div class="col-xs-12 col-sm-12"> <h1>It’s acute hepatic porphyria.</h1> </div> <div class="col-xs-12"><a class="purple-cta" href="/about-ahp">Uncover the disease <span class="arrow">></span></a></div> </div> </div> </div> </section>  <div class="animation-home"> <div class="reverse" id="grayblock"> </div> <div class="container"> <div class="person" id="womanblock"><img id="womanimage" src="/themes/custom/porphyria/assets/images/patient/home/woman.png" /> <img id="grayimage" src="/themes/custom/porphyria/assets/images/patient/home/woman-reverse.png" /></div> <div id="patientlabel"><span class="nowrap">− Megan, living with AHP</span></div> <div class="bluebar" id="bluebar1"><span id="bluebar1text">It started with nausea, vomiting, and fainting.</span></div> <div class="bluebar" id="bluebar2"><span id="bluebar2text">I was treated for ulcerative colitis.</span></div> <div class="bluebar" id="bluebar3"><span id="bluebar3text">Then endometriosis and depression.</span></div> <div class="bluebar" id="bluebar4"><span id="bluebar4text">They said it was all in my head.</span></div> <div class="bluebar" id="bluebar5"><span id="bluebar5text">It’s not.</span></div> <div id="whitebar"><span id="whitebartext">It’s acute hepatic porphyria.</span></div> <a href="/about-ahp" id="purplebar"><span id="purplebartext">Uncover the disease <span>></span></span></a></div> </div>  <section class="ctaSection mustard" style="padding:0;"> <div class="container"> <div class="row"> <div class="col-sm-12 text-center"> <p><a href="/patient-stories/documentary"><strong>Watch the <em style="font-weight: bold;">Two of Me: Living with Porphyria</em> documentary <span>></span></strong></a></p> </div> </div> </div> </section> <section class="headerAndOpeningText"> <div class="container"> <div class="row"> <div class="col-xs-12 col-sm-12"> <div class="mobile-webinar-container"><span style="height: 0;"> </span></div> <h1>COULD IT BE ACUTE HEPATIC PORPHYRIA (AHP)?</h1> <div class="row boot-margins"> <div class="col-xs-12 col-sm-6"> <p>Have you ever had severe abdominal pain, followed by at least one other unexplainable symptom? It could vary from limb, back, or chest pain, nausea, vomiting, confusion, anxiety, seizures, weak limbs, constipation, diarrhea, or dark or reddish urine.</p> <p>The experience may have sent you to the doctor or hospital repeatedly over the years, often resulting in different suspected diagnoses. If this sounds at all familiar, it may be a disease called <strong> acute hepatic porphyria (AHP)</strong>, which represents 4 types of porphyria.</p> <p>Porphyria refers to a family of rare genetic metabolic disorders, and is classified as either acute or cutaneous, depending on the primary symptoms.</p> </div> <div class="col-xs-12 col-sm-6"> <p>The cutaneous types present with blistering of the skin, pain, and/or redness and swelling in sun-exposed areas. The acute types can cause severe abdominal pain and other symptoms. AHP is a disease that people may experience differently. It has a wide array of symptoms that often mimic those of other diseases, making diagnosis difficult. It can even cause potentially life-threatening attacks.</p> <p>The good news is that there is support available and there are ways to test for AHP. This website provides education, resources, and information on the signs and symptoms of AHP, living with AHP, tests to help diagnose AHP, so you can start a conversation with your doctor and get answers.</p> </div> </div> </div> </div> </div> </section> <section id="blueBar"> <div class="container"> <div class="blue-bar">If you suspect you are having symptoms of AHP, it is important to talk with<br class="hidden-xs hidden-sm" /> your doctor about tests that can help diagnose.</div> </div> </section> <section> <div class="container"> <div class="story-boxes"> <div class="row flex-row-container"> <div class="col-xs-12 col-sm-6 box borderright borderbottom flex-row-item"><a href="/about-ahp"><img alt="A person with acute hepatic porphyria outside" class="img-responsive" data-entity-type="file" data-entity-uuid="041e1a6d-2458-4d50-aed5-f76e4368eacc" src="/sites/default/files/inline-images/image1_Heather_0.png" /></a> <div class="content"> <h2><a href="/about-ahp">Recognizing the signs<br class="hidden-xs hidden-sm" /> and symptoms of AHP </a></h2> <p><a href="/about-ahp">is a crucial first step to dealing with the<br class="hidden-xs hidden-sm" /> limitations of this debilitating disease.</a></p> <a href="/about-ahp"><span class="cta">See the Signs and Symptoms</span> </a></div> <a href="/about-ahp"> </a></div> <div class="col-xs-12 col-sm-6 box borderbottom flex-row-item"><a href="/living-with-ahp"><img alt="People with acute hepatic porphyria on a computer" class="img-responsive" data-entity-type="file" data-entity-uuid="0cee864b-eeec-4469-a8b5-c45fbcde67b3" src="/sites/default/files/inline-images/image2_.png" /></a> <div class="content"> <h2><a href="/living-with-ahp">LEARNING HOW<br class="hidden-xs hidden-sm" /> TO LIVE <span class="nowrap">WITH AHP</span></a></h2> <p style="margin-bottom:37px;"><a href="/living-with-ahp">can help you manage it over the long term.</a></p> <a href="/living-with-ahp"><span class="cta">Manage Your AHP</span> </a></div> <a href="/living-with-ahp"> </a></div> </div> <div class="row flex-row-container"> <div class="col-xs-12 col-sm-6 box borderright flex-row-item"><a class="anchorlink" data-anchor="ddg" href="/ahp-resources"><img alt="A person with acute hepatic porphyria using a resource" class="img-responsive" src="/sites/default/files/2020-04/image3.png" /> </a> <div class="content"> <h2><a class="anchorlink" data-anchor="ddg" href="/ahp-resources">DISCUSSING YOUR EXPERIENCE </a></h2> <p class="mh"><a class="anchorlink" data-anchor="ddg" href="/ahp-resources">with your doctor can lead to a better understanding of AHP and its impact.</a></p> <a class="anchorlink" data-anchor="ddg" href="/ahp-resources/doctor-discussion-guide"><span class="cta">Take the Symptom Questionnaire</span> </a></div> <a class="anchorlink" data-anchor="ddg" href="/ahp-resources"> </a></div> <div class="col-xs-12 col-sm-6 box flex-row-item"><a href="/diagnosing-ahp"><img alt="A person discussing acute hepatic porphyria with a doctor" class="img-responsive" src="/themes/custom/porphyria/assets/images/patient/home/image4.png" /> </a> <div class="content"> <h2><a href="/diagnosing-ahp">It’s important to be educated about testing options </a></h2> <p><a href="/diagnosing-ahp">that can help lead to a diagnosis of AHP.</a></p> <a href="/diagnosing-ahp"><span class="cta">Get More Information About Testing</span> </a></div> <a href="/diagnosing-ahp"> </a></div> </div> </div> </div> </section> <a id="signUpNow" name="signUpNow"></a></main> </div> <div id="mouseposition-extension-element-full-container" style="position: fixed; 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