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ENZYME - 2.1.1.57 methyltransferase cap1
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class="main-elmt" style="justify-self:center;"> <table class="type-1"> <tr><th colspan="2">Accepted Name</th></tr> <tr><td colspan="2"><strong property="schema:name">methyltransferase cap1 </strong></td></tr> <tr><th colspan="2">Alternative Name(s)</th></tr> <tr><td colspan="2"><strong property="schema:alternateName">cap1-MTase</strong></td></tr> <tr><td colspan="2"><strong property="schema:alternateName">messenger RNA (nucleoside-2'-)-methyltransferase</strong></td></tr> <tr><td colspan="2"><strong property="schema:alternateName">mRNA (nucleoside-2'-O)-methyltransferase</strong></td></tr> <tr><th colspan="2">Reaction catalysed</th></tr> <tr><td colspan="2">a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA<span class="color_d2"> + </span>S-adenosyl-L-methionine<span class="color_d2"> = </span>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA<span class="color_d2"> + </span>S-adenosyl-L-homocysteine<span class="color_d2"> + </span>H(+)</td></tr> <tr><th colspan="2">Comment(s)</th></tr> <tr><td colspan="2"><ul class="cc"><li>This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules. </li><li>This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. </li><li>The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine. </li><li>Formerly EC 2.1.1.58. </li></ul></td></tr> <tr><th colspan="2">Cross-references</th></tr> <tr><td>BRENDA</td><td><a href="http://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.57">2.1.1.57</a></td></tr> <tr><td>EC2PDB</td><td><a href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=2.1.1.57">2.1.1.57</a></td></tr> <tr><td>ExplorEnz</td><td><a href="http://www.enzyme-database.org/query.php?ec=2.1.1.57">2.1.1.57</a></td></tr> <tr><td>KEGG Ligand Database for Enzyme Nomenclature</td><td><a href="http://www.genome.ad.jp/dbget-bin/www_bget?ec:2.1.1.57">2.1.1.57</a></td></tr> <tr><td>IUBMB Enzyme Nomenclature</td><td><a href="https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC2/1/1/57.html">2.1.1.57</a></td></tr> <tr><td>MEDLINE</td><td><a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=PubMed&details_term=2.1.1.57[EC/RN%20Number]">Find literature relating to 2.1.1.57</a></td></tr> <tr><td>MetaCyc</td><td><a href="https://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-2.1.1.57">2.1.1.57</a></td></tr> <tr><td>Rhea expert-curated reactions</td><td><a href="https://www.rhea-db.org/rhea?query=ec%3A2.1.1.57">2.1.1.57</a></td></tr> <tr><td>UniProtKB/Swiss-Prot</td><td><table> <tr><td><a href="https://www.uniprot.org/uniprot/D2HRF1">D2HRF1</a>, CMTR1_AILME</td><td><a href="https://www.uniprot.org/uniprot/A2VE39">A2VE39</a>, CMTR1_BOVIN</td><td><a href="https://www.uniprot.org/uniprot/Q803R5">Q803R5</a>, CMTR1_DANRE</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q9W4N2">Q9W4N2</a>, CMTR1_DROME</td><td><a href="https://www.uniprot.org/uniprot/Q8N1G2">Q8N1G2</a>, CMTR1_HUMAN</td><td><a href="https://www.uniprot.org/uniprot/Q9DBC3">Q9DBC3</a>, CMTR1_MOUSE</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q5R981">Q5R981</a>, CMTR1_PONAB</td><td><a href="https://www.uniprot.org/uniprot/Q5U2Z5">Q5U2Z5</a>, CMTR1_RAT</td><td><a href="https://www.uniprot.org/uniprot/Q6GQ76">Q6GQ76</a>, CMTR1_XENLA</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P41469">P41469</a>, CMTR_NPVAC</td><td><a href="https://www.uniprot.org/uniprot/P15916">P15916</a>, MCE_FOWPN</td><td><a href="https://www.uniprot.org/uniprot/A0A7H0DN74">A0A7H0DN74</a>, MCE_MONPV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P68544">P68544</a>, MCE_MYXVL</td><td><a href="https://www.uniprot.org/uniprot/P68545">P68545</a>, MCE_MYXVU</td><td><a href="https://www.uniprot.org/uniprot/P19748">P19748</a>, MCE_SHEVK</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P23334">P23334</a>, MCE_SWPVK</td><td><a href="https://www.uniprot.org/uniprot/Q76ZT1">Q76ZT1</a>, MCE_VACCA</td><td><a href="https://www.uniprot.org/uniprot/P21033">P21033</a>, MCE_VACCC</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P07617">P07617</a>, MCE_VACCW</td><td><a href="https://www.uniprot.org/uniprot/P33052">P33052</a>, MCE_VAR67</td><td><a href="https://www.uniprot.org/uniprot/A8XYX2">A8XYX2</a>, MTR1A_CAEBR</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q9NAA5">Q9NAA5</a>, MTR1_CAEEL</td><td><a href="https://www.uniprot.org/uniprot/Q54WR1">Q54WR1</a>, MTR1_DICDI</td><td><a href="https://www.uniprot.org/uniprot/A4HQI9">A4HQI9</a>, MTR1_LEIBR</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q4Q089">Q4Q089</a>, MTR1_LEIMA</td><td><a href="https://www.uniprot.org/uniprot/Q38AH0">Q38AH0</a>, MTR1_TRYB2</td><td><a href="https://www.uniprot.org/uniprot/Q4E123">Q4E123</a>, MTR1_TRYCC</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q91B85">Q91B85</a>, POLG_ALKV</td><td><a href="https://www.uniprot.org/uniprot/C8XPA8">C8XPA8</a>, POLG_BANV</td><td><a href="https://www.uniprot.org/uniprot/Q32ZE0">Q32ZE0</a>, POLG_BUSV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P27909">P27909</a>, POLG_DEN1B</td><td><a href="https://www.uniprot.org/uniprot/P33478">P33478</a>, POLG_DEN1S</td><td><a href="https://www.uniprot.org/uniprot/P17763">P17763</a>, POLG_DEN1W</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P29990">P29990</a>, POLG_DEN26</td><td><a href="https://www.uniprot.org/uniprot/P29991">P29991</a>, POLG_DEN27</td><td><a href="https://www.uniprot.org/uniprot/P14337">P14337</a>, POLG_DEN28</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P07564">P07564</a>, POLG_DEN2J</td><td><a href="https://www.uniprot.org/uniprot/P14340">P14340</a>, POLG_DEN2N</td><td><a href="https://www.uniprot.org/uniprot/P12823">P12823</a>, POLG_DEN2P</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q9WDA6">Q9WDA6</a>, POLG_DEN2Q</td><td><a href="https://www.uniprot.org/uniprot/Q99D35">Q99D35</a>, POLG_DEN3C</td><td><a href="https://www.uniprot.org/uniprot/Q5UB51">Q5UB51</a>, POLG_DEN3I</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q6YMS3">Q6YMS3</a>, POLG_DEN3M</td><td><a href="https://www.uniprot.org/uniprot/P27915">P27915</a>, POLG_DEN3P</td><td><a href="https://www.uniprot.org/uniprot/Q6YMS4">Q6YMS4</a>, POLG_DEN3S</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P09866">P09866</a>, POLG_DEN4D</td><td><a href="https://www.uniprot.org/uniprot/Q2YHF2">Q2YHF2</a>, POLG_DEN4H</td><td><a href="https://www.uniprot.org/uniprot/Q58HT7">Q58HT7</a>, POLG_DEN4P</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q5UCB8">Q5UCB8</a>, POLG_DEN4S</td><td><a href="https://www.uniprot.org/uniprot/Q2YHF0">Q2YHF0</a>, POLG_DEN4T</td><td><a href="https://www.uniprot.org/uniprot/C8XPB2">C8XPB2</a>, POLG_EHV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q32ZD7">Q32ZD7</a>, POLG_ILHV</td><td><a href="https://www.uniprot.org/uniprot/P27395">P27395</a>, POLG_JAEV1</td><td><a href="https://www.uniprot.org/uniprot/P19110">P19110</a>, POLG_JAEV5</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P32886">P32886</a>, POLG_JAEVJ</td><td><a href="https://www.uniprot.org/uniprot/G3FEX6">G3FEX6</a>, POLG_JAEVM</td><td><a href="https://www.uniprot.org/uniprot/D7RF80">D7RF80</a>, POLG_KFDV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q32ZD5">Q32ZD5</a>, POLG_KOKV</td><td><a href="https://www.uniprot.org/uniprot/P14335">P14335</a>, POLG_KUNJM</td><td><a href="https://www.uniprot.org/uniprot/P29837">P29837</a>, POLG_LANVT</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P22338">P22338</a>, POLG_LIV</td><td><a href="https://www.uniprot.org/uniprot/P33515">P33515</a>, POLG_MCFA</td><td><a href="https://www.uniprot.org/uniprot/P05769">P05769</a>, POLG_MVEV5</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q7T6D2">Q7T6D2</a>, POLG_OHFV</td><td><a href="https://www.uniprot.org/uniprot/Q04538">Q04538</a>, POLG_POWVL</td><td><a href="https://www.uniprot.org/uniprot/Q32ZD4">Q32ZD4</a>, POLG_ROCV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P09732">P09732</a>, POLG_STEVM</td><td><a href="https://www.uniprot.org/uniprot/Q01299">Q01299</a>, POLG_TBEVH</td><td><a href="https://www.uniprot.org/uniprot/P07720">P07720</a>, POLG_TBEVS</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P14336">P14336</a>, POLG_TBEVW</td><td><a href="https://www.uniprot.org/uniprot/G1CRV4">G1CRV4</a>, POLG_TMUV</td><td><a href="https://www.uniprot.org/uniprot/Q5WPU5">Q5WPU5</a>, POLG_USUV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P06935">P06935</a>, POLG_WNV</td><td><a href="https://www.uniprot.org/uniprot/Q9Q6P4">Q9Q6P4</a>, POLG_WNV9</td><td><a href="https://www.uniprot.org/uniprot/C5H431">C5H431</a>, POLG_WSLV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P03314">P03314</a>, POLG_YEFV1</td><td><a href="https://www.uniprot.org/uniprot/Q6DV88">Q6DV88</a>, POLG_YEFVA</td><td><a href="https://www.uniprot.org/uniprot/Q6J3P1">Q6J3P1</a>, POLG_YEFVC</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q074N0">Q074N0</a>, POLG_YEFVE</td><td><a href="https://www.uniprot.org/uniprot/Q89277">Q89277</a>, POLG_YEFVF</td><td><a href="https://www.uniprot.org/uniprot/Q98803">Q98803</a>, POLG_YEFVI</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q1X881">Q1X881</a>, POLG_YEFVN</td><td><a href="https://www.uniprot.org/uniprot/Q9YRV3">Q9YRV3</a>, POLG_YEFVT</td><td><a href="https://www.uniprot.org/uniprot/Q1X880">Q1X880</a>, POLG_YEFVU</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q32ZE1">Q32ZE1</a>, POLG_ZIKV</td><td><a href="https://www.uniprot.org/uniprot/A0A024B7W1">A0A024B7W1</a>, POLG_ZIKVF</td><td><a href="https://www.uniprot.org/uniprot/A0A142I5B9">A0A142I5B9</a>, POLG_ZIKVK</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/F8RL29">F8RL29</a>, R1AB_AMV79</td><td><a href="https://www.uniprot.org/uniprot/P0C6W1">P0C6W1</a>, R1AB_BC133</td><td><a href="https://www.uniprot.org/uniprot/P0C6V9">P0C6V9</a>, R1AB_BC279</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6W0">P0C6W0</a>, R1AB_BC512</td><td><a href="https://www.uniprot.org/uniprot/P0C6W2">P0C6W2</a>, R1AB_BCHK3</td><td><a href="https://www.uniprot.org/uniprot/P0C6W3">P0C6W3</a>, R1AB_BCHK4</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6W4">P0C6W4</a>, R1AB_BCHK5</td><td><a href="https://www.uniprot.org/uniprot/P0C6W5">P0C6W5</a>, R1AB_BCHK9</td><td><a href="https://www.uniprot.org/uniprot/P0C6W6">P0C6W6</a>, R1AB_BCRP3</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6W7">P0C6W7</a>, R1AB_CVBEN</td><td><a href="https://www.uniprot.org/uniprot/P0C6W8">P0C6W8</a>, R1AB_CVBLU</td><td><a href="https://www.uniprot.org/uniprot/P0C6W9">P0C6W9</a>, R1AB_CVBM</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6X0">P0C6X0</a>, R1AB_CVBQ</td><td><a href="https://www.uniprot.org/uniprot/P0C6X1">P0C6X1</a>, R1AB_CVH22</td><td><a href="https://www.uniprot.org/uniprot/P0C6X2">P0C6X2</a>, R1AB_CVHN1</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6X3">P0C6X3</a>, R1AB_CVHN2</td><td><a href="https://www.uniprot.org/uniprot/P0C6X4">P0C6X4</a>, R1AB_CVHN5</td><td><a href="https://www.uniprot.org/uniprot/P0C6X5">P0C6X5</a>, R1AB_CVHNL</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6X6">P0C6X6</a>, R1AB_CVHOC</td><td><a href="https://www.uniprot.org/uniprot/P0C6X8">P0C6X8</a>, R1AB_CVM2</td><td><a href="https://www.uniprot.org/uniprot/P0C6X9">P0C6X9</a>, R1AB_CVMA5</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6Y0">P0C6Y0</a>, R1AB_CVMJH</td><td><a href="https://www.uniprot.org/uniprot/P0C6Y5">P0C6Y5</a>, R1AB_CVPPU</td><td><a href="https://www.uniprot.org/uniprot/Q98VG9">Q98VG9</a>, R1AB_FIPV</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0C6Y1">P0C6Y1</a>, R1AB_IBVB</td><td><a href="https://www.uniprot.org/uniprot/P0C6Y2">P0C6Y2</a>, R1AB_IBVBC</td><td><a href="https://www.uniprot.org/uniprot/P0C6Y3">P0C6Y3</a>, R1AB_IBVM</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/K9N7C7">K9N7C7</a>, R1AB_MERS1</td><td><a href="https://www.uniprot.org/uniprot/P0C6Y4">P0C6Y4</a>, R1AB_PEDV7</td><td><a href="https://www.uniprot.org/uniprot/P0C6X7">P0C6X7</a>, R1AB_SARS</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/P0DTD1">P0DTD1</a>, R1AB_SARS2</td><td><a href="https://www.uniprot.org/uniprot/Q008X6">Q008X6</a>, R1AB_WBV24</td></table> </td></tr> </table> <br><a property="schema:sameAs" href="/cgi-bin/enzyme/get-enzyme-entry?2.1.1.57">View entry in original ENZYME format</a> <br><a property="schema:sameAs" href="/EC/2.1.1.57.txt">View entry in raw text format (no links)</a><br> <div property="schema:about" typeof="schema:DataSet"><a property="schema:url" href="https://www.uniprot.org/uniprotkb?query=(ec:2.1.1.57)%20AND%20(reviewed:true)">All UniProtKB/Swiss-Prot entries referenced in this entry</a>, with possibility to download in different formats, align etc. </div> All <a href="/EC/2.1.1.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.1.1.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.1.1.-<br> </span><span property="itemListElement" typeof="ListItem">All <a href="/EC/2.1.-.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.1.-.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.1.-.-<br> All <a href="/EC/2.-.-.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.-.-.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.-.-.-<br> </div> </div> </main> <!-- end of main, start of footer --> 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